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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRMT11-NCOA7 (FusionGDB2 ID:93625)

Fusion Gene Summary for TRMT11-NCOA7

check button Fusion gene summary
Fusion gene informationFusion gene name: TRMT11-NCOA7
Fusion gene ID: 93625
HgeneTgene
Gene symbol

TRMT11

NCOA7

Gene ID

60487

135112

Gene nametRNA methyltransferase 11 homolognuclear receptor coactivator 7
SynonymsC6orf75|MDS024|TRM11|TRMT11-1ERAP140|ESNA1|NCOA7-AS|Nbla00052|Nbla10993|TLDC4|dJ187J11.3
Cytomap

6q22.32

6q22.31-q22.32

Type of geneprotein-codingprotein-coding
DescriptiontRNA (guanine(10)-N2)-methyltransferase homologtRNA guanosine-2'-O-methyltransferase TRM11 homolognuclear receptor coactivator 7140 kDa estrogen receptor-associated proteinTBC/LysM-associated domain containing 4estrogen nuclear receptor coactivator 1estrogen receptor associated protein 140 kDaputative protein product of Nbla00052putative protein
Modification date2020031320200313
UniProtAcc.

Q8NI08

Ensembl transtripts involved in fusion geneENST00000334379, ENST00000368332, 
ENST00000450358, ENST00000489934, 
ENST00000368357, ENST00000392477, 
ENST00000229634, ENST00000487635, 
Fusion gene scores* DoF score11 X 7 X 7=5396 X 7 X 3=126
# samples 147
** MAII scorelog2(14/539*10)=-1.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRMT11 [Title/Abstract] AND NCOA7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRMT11(126307768)-NCOA7(126249320), # samples:2
NCOA7(126176386)-TRMT11(126319199), # samples:1
NCOA7(126176386)-TRMT11(126319369), # samples:1
Anticipated loss of major functional domain due to fusion event.NCOA7-TRMT11 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NCOA7-TRMT11 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TRMT11-NCOA7 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TRMT11-NCOA7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNCOA7

GO:0045944

positive regulation of transcription by RNA polymerase II

11971969


check buttonFusion gene breakpoints across TRMT11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NCOA7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-86-8673-01ATRMT11chr6

126334247

+NCOA7chr6

126243828

+
ChimerDB4UCECTCGA-A5-A2K4-01ATRMT11chr6

126307768

+NCOA7chr6

126249320

+
ChimerDB4UCECTCGA-A5-A2K4-01ATRMT11chr6

126307768

+NCOA7chr6

126249320

+
ChimerDB4LUADTCGA-86-8673-01ATRMT11chr6

126342426

-NCOA7chr6

126242089

+


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Fusion Gene ORF analysis for TRMT11-NCOA7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000334379ENST00000368357TRMT11chr6

126334247

+NCOA7chr6

126243828

+
Frame-shiftENST00000334379ENST00000392477TRMT11chr6

126334247

+NCOA7chr6

126243828

+
Frame-shiftENST00000334379ENST00000229634TRMT11chr6

126334247

+NCOA7chr6

126243828

+
5CDS-intronENST00000334379ENST00000487635TRMT11chr6

126334247

+NCOA7chr6

126243828

+
Frame-shiftENST00000368332ENST00000368357TRMT11chr6

126334247

+NCOA7chr6

126243828

+
Frame-shiftENST00000368332ENST00000392477TRMT11chr6

126334247

+NCOA7chr6

126243828

+
Frame-shiftENST00000368332ENST00000229634TRMT11chr6

126334247

+NCOA7chr6

126243828

+
5CDS-intronENST00000368332ENST00000487635TRMT11chr6

126334247

+NCOA7chr6

126243828

+
intron-3CDSENST00000450358ENST00000368357TRMT11chr6

126334247

+NCOA7chr6

126243828

+
intron-3CDSENST00000450358ENST00000392477TRMT11chr6

126334247

+NCOA7chr6

126243828

+
intron-3CDSENST00000450358ENST00000229634TRMT11chr6

126334247

+NCOA7chr6

126243828

+
intron-intronENST00000450358ENST00000487635TRMT11chr6

126334247

+NCOA7chr6

126243828

+
intron-3CDSENST00000489934ENST00000368357TRMT11chr6

126334247

+NCOA7chr6

126243828

+
intron-3CDSENST00000489934ENST00000392477TRMT11chr6

126334247

+NCOA7chr6

126243828

+
intron-3CDSENST00000489934ENST00000229634TRMT11chr6

126334247

+NCOA7chr6

126243828

+
intron-intronENST00000489934ENST00000487635TRMT11chr6

126334247

+NCOA7chr6

126243828

+
In-frameENST00000334379ENST00000368357TRMT11chr6

126307768

+NCOA7chr6

126249320

+
In-frameENST00000334379ENST00000392477TRMT11chr6

126307768

+NCOA7chr6

126249320

+
In-frameENST00000334379ENST00000229634TRMT11chr6

126307768

+NCOA7chr6

126249320

+
5CDS-intronENST00000334379ENST00000487635TRMT11chr6

126307768

+NCOA7chr6

126249320

+
In-frameENST00000368332ENST00000368357TRMT11chr6

126307768

+NCOA7chr6

126249320

+
In-frameENST00000368332ENST00000392477TRMT11chr6

126307768

+NCOA7chr6

126249320

+
In-frameENST00000368332ENST00000229634TRMT11chr6

126307768

+NCOA7chr6

126249320

+
5CDS-intronENST00000368332ENST00000487635TRMT11chr6

126307768

+NCOA7chr6

126249320

+
In-frameENST00000450358ENST00000368357TRMT11chr6

126307768

+NCOA7chr6

126249320

+
In-frameENST00000450358ENST00000392477TRMT11chr6

126307768

+NCOA7chr6

126249320

+
In-frameENST00000450358ENST00000229634TRMT11chr6

126307768

+NCOA7chr6

126249320

+
5CDS-intronENST00000450358ENST00000487635TRMT11chr6

126307768

+NCOA7chr6

126249320

+
intron-3CDSENST00000489934ENST00000368357TRMT11chr6

126307768

+NCOA7chr6

126249320

+
intron-3CDSENST00000489934ENST00000392477TRMT11chr6

126307768

+NCOA7chr6

126249320

+
intron-3CDSENST00000489934ENST00000229634TRMT11chr6

126307768

+NCOA7chr6

126249320

+
intron-intronENST00000489934ENST00000487635TRMT11chr6

126307768

+NCOA7chr6

126249320

+
In-frameENST00000334379ENST00000368357TRMT11chr6

126342426

-NCOA7chr6

126242089

+
In-frameENST00000334379ENST00000392477TRMT11chr6

126342426

-NCOA7chr6

126242089

+
In-frameENST00000334379ENST00000229634TRMT11chr6

126342426

-NCOA7chr6

126242089

+
5CDS-intronENST00000334379ENST00000487635TRMT11chr6

126342426

-NCOA7chr6

126242089

+
intron-3CDSENST00000368332ENST00000368357TRMT11chr6

126342426

-NCOA7chr6

126242089

+
intron-3CDSENST00000368332ENST00000392477TRMT11chr6

126342426

-NCOA7chr6

126242089

+
intron-3CDSENST00000368332ENST00000229634TRMT11chr6

126342426

-NCOA7chr6

126242089

+
intron-intronENST00000368332ENST00000487635TRMT11chr6

126342426

-NCOA7chr6

126242089

+
intron-3CDSENST00000450358ENST00000368357TRMT11chr6

126342426

-NCOA7chr6

126242089

+
intron-3CDSENST00000450358ENST00000392477TRMT11chr6

126342426

-NCOA7chr6

126242089

+
intron-3CDSENST00000450358ENST00000229634TRMT11chr6

126342426

-NCOA7chr6

126242089

+
intron-intronENST00000450358ENST00000487635TRMT11chr6

126342426

-NCOA7chr6

126242089

+
intron-3CDSENST00000489934ENST00000368357TRMT11chr6

126342426

-NCOA7chr6

126242089

+
intron-3CDSENST00000489934ENST00000392477TRMT11chr6

126342426

-NCOA7chr6

126242089

+
intron-3CDSENST00000489934ENST00000229634TRMT11chr6

126342426

-NCOA7chr6

126242089

+
intron-intronENST00000489934ENST00000487635TRMT11chr6

126342426

-NCOA7chr6

126242089

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334379TRMT11chr6126342426-ENST00000368357NCOA7chr6126242089+43061381401965641
ENST00000334379TRMT11chr6126342426-ENST00000392477NCOA7chr6126242089+43151381401965641
ENST00000334379TRMT11chr6126342426-ENST00000229634NCOA7chr6126242089+22221381401965641

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334379ENST00000368357TRMT11chr6126342426-NCOA7chr6126242089+0.0003380860.9996619
ENST00000334379ENST00000392477TRMT11chr6126342426-NCOA7chr6126242089+0.0003349790.999665
ENST00000334379ENST00000229634TRMT11chr6126342426-NCOA7chr6126242089+0.001252370.9987476

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Fusion Genomic Features for TRMT11-NCOA7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TRMT11chr6126307768+NCOA7chr6126249319+0.0040828140.99591714
TRMT11chr6126334247+NCOA7chr6126243827+0.0009498780.9990501
TRMT11chr6126307768+NCOA7chr6126249319+0.0040828140.99591714
TRMT11chr6126334247+NCOA7chr6126243827+0.0009498780.9990501

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRMT11-NCOA7


check button Go to

FGviewer for the breakpoints of chr6:126307768-chr6:126249320

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NCOA7

Q8NI08

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNCOA7chr6:126307768chr6:126249320ENST000002296341215781_942758.0828.0DomainTLDc
TgeneNCOA7chr6:126342426chr6:126242089ENST00000229634915781_942633.0828.0DomainTLDc
TgeneNCOA7chr6:126342426chr6:126242089ENST000003683571117781_942748.0943.0DomainTLDc
TgeneNCOA7chr6:126342426chr6:126242089ENST000003924771016781_942748.0943.0DomainTLDc

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNCOA7chr6:126307768chr6:126249320ENST0000022963412154_29758.0828.0Coiled coilOntology_term=ECO:0000255
TgeneNCOA7chr6:126307768chr6:126249320ENST0000036835714174_29873.0943.0Coiled coilOntology_term=ECO:0000255
TgeneNCOA7chr6:126307768chr6:126249320ENST0000039247713164_29873.0943.0Coiled coilOntology_term=ECO:0000255
TgeneNCOA7chr6:126342426chr6:126242089ENST000002296349154_29633.0828.0Coiled coilOntology_term=ECO:0000255
TgeneNCOA7chr6:126342426chr6:126242089ENST0000036835711174_29748.0943.0Coiled coilOntology_term=ECO:0000255
TgeneNCOA7chr6:126342426chr6:126242089ENST0000039247710164_29748.0943.0Coiled coilOntology_term=ECO:0000255
TgeneNCOA7chr6:126307768chr6:126249320ENST000002296341215114_157758.0828.0DomainLysM
TgeneNCOA7chr6:126307768chr6:126249320ENST000003683571417114_157873.0943.0DomainLysM
TgeneNCOA7chr6:126307768chr6:126249320ENST000003683571417781_942873.0943.0DomainTLDc
TgeneNCOA7chr6:126307768chr6:126249320ENST000003924771316114_157873.0943.0DomainLysM
TgeneNCOA7chr6:126307768chr6:126249320ENST000003924771316781_942873.0943.0DomainTLDc
TgeneNCOA7chr6:126342426chr6:126242089ENST00000229634915114_157633.0828.0DomainLysM
TgeneNCOA7chr6:126342426chr6:126242089ENST000003683571117114_157748.0943.0DomainLysM
TgeneNCOA7chr6:126342426chr6:126242089ENST000003924771016114_157748.0943.0DomainLysM


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Fusion Gene Sequence for TRMT11-NCOA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000334379_ENST00000368357_TCGA-86-8673-01A_TRMT11_chr6_126342426_-_NCOA7_chr6_126242089_length(transcript)=4306nt_BP=1381nt
CGCCTGCCTCGCAGAGCTTCCGCTTCCGGCCCTTCAGGCTCTGTCTCTGTGGAGACTGGGCTTTGGGAGGGAGAAAGAGGGACCTAGCGC
GGGCCGCGCAGGCGCACGGTGGGCAGCTGCAATGGCGCTGTCGTGTACCCTTAACAGGTATCTGCTCCTCATGGCGCAGGAGCATCTGGA
GTTCCGCCTGCCGGAAATAAAGTCTTTGCTTTTGCTTTTTGGAGGTCAGTTTGCCAGCAGTCAAGAAACTTATGGAAAGTCACCATTTTG
GATTCTTAGCATTCCCTCTGAAGATATTGCAAGAAATTTGATGAAACGGACAGTGTGTGCCAAGTCTATATTTGAACTATGGGGTCATGG
ACAATCTCCTGAGGAGCTGTACAGTTCTCTTAAAAACTACCCTGTGGAGAAGATGGTTCCATTTCTACATTCGGACTCTACATATAAAAT
AAAGATTCACACTTTTAATAAGACATTGACACAAGAAGAGAAAATCAAGCGAATAGATGCACTTGAATTTCTGCCATTTGAAGGAAAAGT
GAATTTAAAGAAACCGCAACATGTATTTTCTGTTTTGGAGGATTATGGTTTAGACCCAAACTGCATCCCTGAGAATCCACATAATATTTA
TTTTGGTAGATGGATTGCAGATGGACAGAGAGAGCTTATTGAGTCATACAGTGTCAAAAAGAGACACTTTATTGGAAATACAAGTATGGA
TGCTGGTTTGTCATTCATTATGGCTAACCATGGAAAAGTGAAAGAAAATGATATTGTCTTTGATCCATTTGTTGGAACAGGTGGCCTGCT
GATAGCATGTGCTCATTTTGGTGCATATGTGTATGGGACAGACATAGACTACAACACAGTTCATGGCTTGGGAAAGGCTACTAGGAAAAA
CCAGAAGTGGAGAGGACCAGATGAAAACATTAGGGCCAATCTTCGTCAATATGGTTTAGAGAAGTATTACCTTGATGTCCTGGTTTCAGA
TGCATCTAAACCTTCCTGGAGGAAGGGCACATATTTTGATGCAATCATTACTGATCCTCCATATGGTATCAGAGAATCTACAAGAAGAAC
AGGTTCACAGAAGGAGATACCAAAGGGGATAGAAAAATGGGAAAAATGTCCAGAAAGCCATGTTCCTGTTTCCTTGAGTTATCATCTGAG
TGATATGTTTCTTGACCTGTTAAACTTCGCAGCTGAGACCCTCGTTTTAGGTGGAAGACTAGTCTATTGGTTACCGGTGTATACGCCAGA
ATACACTGAAGAGATGGTGCCTTGGCACCCTTGCCTGGAACTCGTTAGCAACTGCGAGCAGAAGCTTTCCAGTCACACATCAAGGCGCTT
GATCACAATGGAAAAGGTGAAGAAATTTGAGATCATCACTGTTGAAGAGGCAAAGCGCAGGAAGAGCACATGCAGCTACTATGAAGACGA
GGACGAAGAGGTGCTGCCTGTCCTACGGCCCCACAGCGCGCTCCTGGAGAATATGCACATCGAGCAGCTGGCCCGACGCCTTCCTGCAAG
GGTGCAAGGGTATCCATGGAGACTGGCCTATAGCACGTTAGAGCACGGGACCAGCTTAAAGACGCTCTACCGGAAATCGGCATCACTAGA
CAGTCCTGTCCTATTGGTCATCAAAGATATGGATAATCAGATTTTTGGAGCATATGCAACTCATCCTTTCAAGTTCAGTGACCACTATTA
TGGCACAGGCGAAACTTTTCTCTACACATTCAGCCCTCATTTTAAGGTCTTTAAGTGGAGTGGAGAAAATTCATACTTTATCAATGGAGA
CATAAGTTCTTTAGAACTTGGTGGTGGAGGGGGACGATTTGGTTTATGGCTAGATGCTGATTTATACCACGGACGAAGCAACTCTTGCAG
CACTTTCAATAATGATATTCTTTCCAAAAAGGAAGACTTCATAGTTCAGGATCTGGAGGTGTGGGCATTTGATTGAAATTCAGACTGCCT
TAAAATATAACATTAAAAAGACTGGGTTCGATCAGCCCTCCTAAAGCTGGCTGGAAAAAGAAGCCCCAGCCCAGCCTGCCTCATCCCACC
CCAATGCTTCCTTTCTGCCATCATCTCAGAGCATGATCACATTGCAGAAAGATTCTGGAAGGTCCATGTAGAGGGCAGACATTGAAGAAA
GAAACTTAAAATCCAGGTTGTTGAAAAGACTTTGTACTCCCACTTCCTCCAAATCCATACAGTGAGGAATCAGAGTGTTTATAGATATAT
GAGTTGAATGCAATTTTTATTTTTGGTAACTGTGAAAAATAAGATACTGTGGATATATACATGCCTTGTGTATTTATCAGCATAATTTTC
ATTACCAAAATGTACAGCTATTATTTGCCATGGAAAAGGTTAGTCTCATTTAGAAAAATCGAAAGTGCACAGCACTTAAAGGGAATATAT
GAGGTTTTTTTTTTTTTAAAAAAAAACTTTTATTTATTATTTGTAGTATATTGTCTGAAATGTGTCGGCAGTTTTTTTTCTTTTAATGTG
TCAAATCTTGAAATATTAAATGTATACATTTTGTGCTATGTTTTGGGAACAAATCTGTTTGATTTATATAGTTTTATATTGAATTTTTTT
TGCCCTGATTGTTTAGGGTGATAGGTCTTAAGCAGCATATATCTATATATCTGTATGTGGGTATATAGAGATATATGTGTGTGTGTATGT
ATATGTACATATACATATATATGAGTGTATAATTCTAAATTTCTAAAAACTCATTATGAATGTTCATCAATTTGACTATTATAGGCCAGC
TTTCCATTTAGTCAATAAAAGCGTACATTTTTAGTTACTTACCTTGAACATATTCGTGTGAAAAAGAATACATCATTTCTCACAGTCTTA
AGTTGATATTTATAGAAATGAATACCTTTGTGAACCTAGACTTAGAACAAATCCTGCTTTTGAAAAAAAATGTTTTGCTTCTTACAAAAT
CATTTGTGTTAATAACAAAAACTTTATTTTCGGAGTGTTCTTTGTATAACTTTTCCAAGCTTTTACATTAACGAGCAGGCCTCTGTCTTA
AAAGGGACTCAGTATATTAATTTCTGCATTTTTTAAATCAAATGAAAAACGTCAAATTGGACCAATTGTCTTGGTTTCTTGATTCATTTA
TTTGAGAAAAAAACAATACAAAGAAATGCATTCATATCAAAATTGGAATAGAAAGGAAAACCTATTTTTAAGATATCAACCTATTTTCAC
ATCATAAAACATCTATTACATAAAATAAAGGTCCAGGCATAGTGGCTCTTGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGA
TCACTCAAGGTCACAAGTTTGAGACCAGTCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAGTACAAATATTAGCCGACTATGTGGC
GGGCACCTGTAATCCCACCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCGGGAAGCAGAGGTTGTAGTGAGCCAAGATCGTGC
CACTGCACTCTATCCTGGGTAACAGCGAGACTCTGTCTTAAAAATAATAACAATAATAATAATAATAAAGACTTACTTAACCAATATTAT
TGATTACCAGACTTTTATGAAAGCCAAAGACTGCTTGCTAGTAGGAAAAAATTTCAAATAATAACCAAAGCTGAAAAATGGTCTGTCATA
AATTATTTCCCCGGTAATTTTTGAAAGGAAAAATGTATAACAAGTACTATTTACATATCTGCATTTAAAAAAGCAATTCTTAGAATACTT
CCTTTACATTATTCTCCTATTTTAGACATTTTGTGAAAGAGAACAAATTGTCCAGTGGCCTCCTGTCAGATCAACAATTATTATACTCCT
TAATTCCATGCAAATTTAAATGAATGCTATAAAATTTTAAATCTGTAGCCTGGGTGTACGTTTCACTCAAGTTCTCCTACTGAGGACTCT
TGACTAACAGCATACTGGCAGTTTCACCTTAACCTGCTCGTTAAATAATGTGTTGGTGTGAGATATCAGGAATGTCTCATGATATCACGT
TTACCATTTACACCATCTGCAACCATATGCTATTAATAAAATGGAAAAAAACAAAATGGTCATTTTGCATATACTTCACTCTGACCTAGT
TTAGTCCATGATACTATAATTGTGAGAGCATATCCAGATGCTGTGTTCTCTATGTAAAACAGTATTGTCCATTCAGAAATGTGTGACCCT

>In-frame_ENST00000334379_ENST00000368357_TCGA-86-8673-01A_TRMT11_chr6_126342426_-_NCOA7_chr6_126242089_length(amino acids)=641AA_start in transcript=40_stop in transcript=1965
MSLWRLGFGREKEGPSAGRAGARWAAAMALSCTLNRYLLLMAQEHLEFRLPEIKSLLLLFGGQFASSQETYGKSPFWILSIPSEDIARNL
MKRTVCAKSIFELWGHGQSPEELYSSLKNYPVEKMVPFLHSDSTYKIKIHTFNKTLTQEEKIKRIDALEFLPFEGKVNLKKPQHVFSVLE
DYGLDPNCIPENPHNIYFGRWIADGQRELIESYSVKKRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGTGGLLIACAHFGAYVYGT
DIDYNTVHGLGKATRKNQKWRGPDENIRANLRQYGLEKYYLDVLVSDASKPSWRKGTYFDAIITDPPYGIRESTRRTGSQKEIPKGIEKW
EKCPESHVPVSLSYHLSDMFLDLLNFAAETLVLGGRLVYWLPVYTPEYTEEMVPWHPCLELVSNCEQKLSSHTSRRLITMEKVKKFEIIT
VEEAKRRKSTCSYYEDEDEEVLPVLRPHSALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQ
IFGAYATHPFKFSDHYYGTGETFLYTFSPHFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDF

--------------------------------------------------------------
>In-frame_ENST00000334379_ENST00000392477_TCGA-86-8673-01A_TRMT11_chr6_126342426_-_NCOA7_chr6_126242089_length(transcript)=4315nt_BP=1381nt
CGCCTGCCTCGCAGAGCTTCCGCTTCCGGCCCTTCAGGCTCTGTCTCTGTGGAGACTGGGCTTTGGGAGGGAGAAAGAGGGACCTAGCGC
GGGCCGCGCAGGCGCACGGTGGGCAGCTGCAATGGCGCTGTCGTGTACCCTTAACAGGTATCTGCTCCTCATGGCGCAGGAGCATCTGGA
GTTCCGCCTGCCGGAAATAAAGTCTTTGCTTTTGCTTTTTGGAGGTCAGTTTGCCAGCAGTCAAGAAACTTATGGAAAGTCACCATTTTG
GATTCTTAGCATTCCCTCTGAAGATATTGCAAGAAATTTGATGAAACGGACAGTGTGTGCCAAGTCTATATTTGAACTATGGGGTCATGG
ACAATCTCCTGAGGAGCTGTACAGTTCTCTTAAAAACTACCCTGTGGAGAAGATGGTTCCATTTCTACATTCGGACTCTACATATAAAAT
AAAGATTCACACTTTTAATAAGACATTGACACAAGAAGAGAAAATCAAGCGAATAGATGCACTTGAATTTCTGCCATTTGAAGGAAAAGT
GAATTTAAAGAAACCGCAACATGTATTTTCTGTTTTGGAGGATTATGGTTTAGACCCAAACTGCATCCCTGAGAATCCACATAATATTTA
TTTTGGTAGATGGATTGCAGATGGACAGAGAGAGCTTATTGAGTCATACAGTGTCAAAAAGAGACACTTTATTGGAAATACAAGTATGGA
TGCTGGTTTGTCATTCATTATGGCTAACCATGGAAAAGTGAAAGAAAATGATATTGTCTTTGATCCATTTGTTGGAACAGGTGGCCTGCT
GATAGCATGTGCTCATTTTGGTGCATATGTGTATGGGACAGACATAGACTACAACACAGTTCATGGCTTGGGAAAGGCTACTAGGAAAAA
CCAGAAGTGGAGAGGACCAGATGAAAACATTAGGGCCAATCTTCGTCAATATGGTTTAGAGAAGTATTACCTTGATGTCCTGGTTTCAGA
TGCATCTAAACCTTCCTGGAGGAAGGGCACATATTTTGATGCAATCATTACTGATCCTCCATATGGTATCAGAGAATCTACAAGAAGAAC
AGGTTCACAGAAGGAGATACCAAAGGGGATAGAAAAATGGGAAAAATGTCCAGAAAGCCATGTTCCTGTTTCCTTGAGTTATCATCTGAG
TGATATGTTTCTTGACCTGTTAAACTTCGCAGCTGAGACCCTCGTTTTAGGTGGAAGACTAGTCTATTGGTTACCGGTGTATACGCCAGA
ATACACTGAAGAGATGGTGCCTTGGCACCCTTGCCTGGAACTCGTTAGCAACTGCGAGCAGAAGCTTTCCAGTCACACATCAAGGCGCTT
GATCACAATGGAAAAGGTGAAGAAATTTGAGATCATCACTGTTGAAGAGGCAAAGCGCAGGAAGAGCACATGCAGCTACTATGAAGACGA
GGACGAAGAGGTGCTGCCTGTCCTACGGCCCCACAGCGCGCTCCTGGAGAATATGCACATCGAGCAGCTGGCCCGACGCCTTCCTGCAAG
GGTGCAAGGGTATCCATGGAGACTGGCCTATAGCACGTTAGAGCACGGGACCAGCTTAAAGACGCTCTACCGGAAATCGGCATCACTAGA
CAGTCCTGTCCTATTGGTCATCAAAGATATGGATAATCAGATTTTTGGAGCATATGCAACTCATCCTTTCAAGTTCAGTGACCACTATTA
TGGCACAGGCGAAACTTTTCTCTACACATTCAGCCCTCATTTTAAGGTCTTTAAGTGGAGTGGAGAAAATTCATACTTTATCAATGGAGA
CATAAGTTCTTTAGAACTTGGTGGTGGAGGGGGACGATTTGGTTTATGGCTAGATGCTGATTTATACCACGGACGAAGCAACTCTTGCAG
CACTTTCAATAATGATATTCTTTCCAAAAAGGAAGACTTCATAGTTCAGGATCTGGAGGTGTGGGCATTTGATTGAAATTCAGACTGCCT
TAAAATATAACATTAAAAAGACTGGGTTCGATCAGCCCTCCTAAAGCTGGCTGGAAAAAGAAGCCCCAGCCCAGCCTGCCTCATCCCACC
CCAATGCTTCCTTTCTGCCATCATCTCAGAGCATGATCACATTGCAGAAAGATTCTGGAAGGTCCATGTAGAGGGCAGACATTGAAGAAA
GAAACTTAAAATCCAGGTTGTTGAAAAGACTTTGTACTCCCACTTCCTCCAAATCCATACAGTGAGGAATCAGAGTGTTTATAGATATAT
GAGTTGAATGCAATTTTTATTTTTGGTAACTGTGAAAAATAAGATACTGTGGATATATACATGCCTTGTGTATTTATCAGCATAATTTTC
ATTACCAAAATGTACAGCTATTATTTGCCATGGAAAAGGTTAGTCTCATTTAGAAAAATCGAAAGTGCACAGCACTTAAAGGGAATATAT
GAGGTTTTTTTTTTTTTAAAAAAAAACTTTTATTTATTATTTGTAGTATATTGTCTGAAATGTGTCGGCAGTTTTTTTTCTTTTAATGTG
TCAAATCTTGAAATATTAAATGTATACATTTTGTGCTATGTTTTGGGAACAAATCTGTTTGATTTATATAGTTTTATATTGAATTTTTTT
TGCCCTGATTGTTTAGGGTGATAGGTCTTAAGCAGCATATATCTATATATCTGTATGTGGGTATATAGAGATATATGTGTGTGTGTATGT
ATATGTACATATACATATATATGAGTGTATAATTCTAAATTTCTAAAAACTCATTATGAATGTTCATCAATTTGACTATTATAGGCCAGC
TTTCCATTTAGTCAATAAAAGCGTACATTTTTAGTTACTTACCTTGAACATATTCGTGTGAAAAAGAATACATCATTTCTCACAGTCTTA
AGTTGATATTTATAGAAATGAATACCTTTGTGAACCTAGACTTAGAACAAATCCTGCTTTTGAAAAAAAATGTTTTGCTTCTTACAAAAT
CATTTGTGTTAATAACAAAAACTTTATTTTCGGAGTGTTCTTTGTATAACTTTTCCAAGCTTTTACATTAACGAGCAGGCCTCTGTCTTA
AAAGGGACTCAGTATATTAATTTCTGCATTTTTTAAATCAAATGAAAAACGTCAAATTGGACCAATTGTCTTGGTTTCTTGATTCATTTA
TTTGAGAAAAAAACAATACAAAGAAATGCATTCATATCAAAATTGGAATAGAAAGGAAAACCTATTTTTAAGATATCAACCTATTTTCAC
ATCATAAAACATCTATTACATAAAATAAAGGTCCAGGCATAGTGGCTCTTGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGA
TCACTCAAGGTCACAAGTTTGAGACCAGTCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAGTACAAATATTAGCCGACTATGTGGC
GGGCACCTGTAATCCCACCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCGGGAAGCAGAGGTTGTAGTGAGCCAAGATCGTGC
CACTGCACTCTATCCTGGGTAACAGCGAGACTCTGTCTTAAAAATAATAACAATAATAATAATAATAAAGACTTACTTAACCAATATTAT
TGATTACCAGACTTTTATGAAAGCCAAAGACTGCTTGCTAGTAGGAAAAAATTTCAAATAATAACCAAAGCTGAAAAATGGTCTGTCATA
AATTATTTCCCCGGTAATTTTTGAAAGGAAAAATGTATAACAAGTACTATTTACATATCTGCATTTAAAAAAGCAATTCTTAGAATACTT
CCTTTACATTATTCTCCTATTTTAGACATTTTGTGAAAGAGAACAAATTGTCCAGTGGCCTCCTGTCAGATCAACAATTATTATACTCCT
TAATTCCATGCAAATTTAAATGAATGCTATAAAATTTTAAATCTGTAGCCTGGGTGTACGTTTCACTCAAGTTCTCCTACTGAGGACTCT
TGACTAACAGCATACTGGCAGTTTCACCTTAACCTGCTCGTTAAATAATGTGTTGGTGTGAGATATCAGGAATGTCTCATGATATCACGT
TTACCATTTACACCATCTGCAACCATATGCTATTAATAAAATGGAAAAAAACAAAATGGTCATTTTGCATATACTTCACTCTGACCTAGT
TTAGTCCATGATACTATAATTGTGAGAGCATATCCAGATGCTGTGTTCTCTATGTAAAACAGTATTGTCCATTCAGAAATGTGTGACCCT

>In-frame_ENST00000334379_ENST00000392477_TCGA-86-8673-01A_TRMT11_chr6_126342426_-_NCOA7_chr6_126242089_length(amino acids)=641AA_start in transcript=40_stop in transcript=1965
MSLWRLGFGREKEGPSAGRAGARWAAAMALSCTLNRYLLLMAQEHLEFRLPEIKSLLLLFGGQFASSQETYGKSPFWILSIPSEDIARNL
MKRTVCAKSIFELWGHGQSPEELYSSLKNYPVEKMVPFLHSDSTYKIKIHTFNKTLTQEEKIKRIDALEFLPFEGKVNLKKPQHVFSVLE
DYGLDPNCIPENPHNIYFGRWIADGQRELIESYSVKKRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGTGGLLIACAHFGAYVYGT
DIDYNTVHGLGKATRKNQKWRGPDENIRANLRQYGLEKYYLDVLVSDASKPSWRKGTYFDAIITDPPYGIRESTRRTGSQKEIPKGIEKW
EKCPESHVPVSLSYHLSDMFLDLLNFAAETLVLGGRLVYWLPVYTPEYTEEMVPWHPCLELVSNCEQKLSSHTSRRLITMEKVKKFEIIT
VEEAKRRKSTCSYYEDEDEEVLPVLRPHSALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQ
IFGAYATHPFKFSDHYYGTGETFLYTFSPHFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDF

--------------------------------------------------------------
>In-frame_ENST00000334379_ENST00000229634_TCGA-86-8673-01A_TRMT11_chr6_126342426_-_NCOA7_chr6_126242089_length(transcript)=2222nt_BP=1381nt
CGCCTGCCTCGCAGAGCTTCCGCTTCCGGCCCTTCAGGCTCTGTCTCTGTGGAGACTGGGCTTTGGGAGGGAGAAAGAGGGACCTAGCGC
GGGCCGCGCAGGCGCACGGTGGGCAGCTGCAATGGCGCTGTCGTGTACCCTTAACAGGTATCTGCTCCTCATGGCGCAGGAGCATCTGGA
GTTCCGCCTGCCGGAAATAAAGTCTTTGCTTTTGCTTTTTGGAGGTCAGTTTGCCAGCAGTCAAGAAACTTATGGAAAGTCACCATTTTG
GATTCTTAGCATTCCCTCTGAAGATATTGCAAGAAATTTGATGAAACGGACAGTGTGTGCCAAGTCTATATTTGAACTATGGGGTCATGG
ACAATCTCCTGAGGAGCTGTACAGTTCTCTTAAAAACTACCCTGTGGAGAAGATGGTTCCATTTCTACATTCGGACTCTACATATAAAAT
AAAGATTCACACTTTTAATAAGACATTGACACAAGAAGAGAAAATCAAGCGAATAGATGCACTTGAATTTCTGCCATTTGAAGGAAAAGT
GAATTTAAAGAAACCGCAACATGTATTTTCTGTTTTGGAGGATTATGGTTTAGACCCAAACTGCATCCCTGAGAATCCACATAATATTTA
TTTTGGTAGATGGATTGCAGATGGACAGAGAGAGCTTATTGAGTCATACAGTGTCAAAAAGAGACACTTTATTGGAAATACAAGTATGGA
TGCTGGTTTGTCATTCATTATGGCTAACCATGGAAAAGTGAAAGAAAATGATATTGTCTTTGATCCATTTGTTGGAACAGGTGGCCTGCT
GATAGCATGTGCTCATTTTGGTGCATATGTGTATGGGACAGACATAGACTACAACACAGTTCATGGCTTGGGAAAGGCTACTAGGAAAAA
CCAGAAGTGGAGAGGACCAGATGAAAACATTAGGGCCAATCTTCGTCAATATGGTTTAGAGAAGTATTACCTTGATGTCCTGGTTTCAGA
TGCATCTAAACCTTCCTGGAGGAAGGGCACATATTTTGATGCAATCATTACTGATCCTCCATATGGTATCAGAGAATCTACAAGAAGAAC
AGGTTCACAGAAGGAGATACCAAAGGGGATAGAAAAATGGGAAAAATGTCCAGAAAGCCATGTTCCTGTTTCCTTGAGTTATCATCTGAG
TGATATGTTTCTTGACCTGTTAAACTTCGCAGCTGAGACCCTCGTTTTAGGTGGAAGACTAGTCTATTGGTTACCGGTGTATACGCCAGA
ATACACTGAAGAGATGGTGCCTTGGCACCCTTGCCTGGAACTCGTTAGCAACTGCGAGCAGAAGCTTTCCAGTCACACATCAAGGCGCTT
GATCACAATGGAAAAGGTGAAGAAATTTGAGATCATCACTGTTGAAGAGGCAAAGCGCAGGAAGAGCACATGCAGCTACTATGAAGACGA
GGACGAAGAGGTGCTGCCTGTCCTACGGCCCCACAGCGCGCTCCTGGAGAATATGCACATCGAGCAGCTGGCCCGACGCCTTCCTGCAAG
GGTGCAAGGGTATCCATGGAGACTGGCCTATAGCACGTTAGAGCACGGGACCAGCTTAAAGACGCTCTACCGGAAATCGGCATCACTAGA
CAGTCCTGTCCTATTGGTCATCAAAGATATGGATAATCAGATTTTTGGAGCATATGCAACTCATCCTTTCAAGTTCAGTGACCACTATTA
TGGCACAGGCGAAACTTTTCTCTACACATTCAGCCCTCATTTTAAGGTCTTTAAGTGGAGTGGAGAAAATTCATACTTTATCAATGGAGA
CATAAGTTCTTTAGAACTTGGTGGTGGAGGGGGACGATTTGGTTTATGGCTAGATGCTGATTTATACCACGGACGAAGCAACTCTTGCAG
CACTTTCAATAATGATATTCTTTCCAAAAAGGAAGACTTCATAGTTCAGGATCTGGAGGTGTGGGCATTTGATTGAAATTCAGACTGCCT
TAAAATATAACATTAAAAAGACTGGGTTCGATCAGCCCTCCTAAAGCTGGCTGGAAAAAGAAGCCCCAGCCCAGCCTGCCTCATCCCACC
CCAATGCTTCCTTTCTGCCATCATCTCAGAGCATGATCACATTGCAGAAAGATTCTGGAAGGTCCATGTAGAGGGCAGACATTGAAGAAA

>In-frame_ENST00000334379_ENST00000229634_TCGA-86-8673-01A_TRMT11_chr6_126342426_-_NCOA7_chr6_126242089_length(amino acids)=641AA_start in transcript=40_stop in transcript=1965
MSLWRLGFGREKEGPSAGRAGARWAAAMALSCTLNRYLLLMAQEHLEFRLPEIKSLLLLFGGQFASSQETYGKSPFWILSIPSEDIARNL
MKRTVCAKSIFELWGHGQSPEELYSSLKNYPVEKMVPFLHSDSTYKIKIHTFNKTLTQEEKIKRIDALEFLPFEGKVNLKKPQHVFSVLE
DYGLDPNCIPENPHNIYFGRWIADGQRELIESYSVKKRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGTGGLLIACAHFGAYVYGT
DIDYNTVHGLGKATRKNQKWRGPDENIRANLRQYGLEKYYLDVLVSDASKPSWRKGTYFDAIITDPPYGIRESTRRTGSQKEIPKGIEKW
EKCPESHVPVSLSYHLSDMFLDLLNFAAETLVLGGRLVYWLPVYTPEYTEEMVPWHPCLELVSNCEQKLSSHTSRRLITMEKVKKFEIIT
VEEAKRRKSTCSYYEDEDEEVLPVLRPHSALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQ
IFGAYATHPFKFSDHYYGTGETFLYTFSPHFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TRMT11-NCOA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRMT11-NCOA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRMT11-NCOA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRMT11C0006142Malignant neoplasm of breast1CTD_human
HgeneTRMT11C0007102Malignant tumor of colon1CTD_human
HgeneTRMT11C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneTRMT11C0009375Colonic Neoplasms1CTD_human
HgeneTRMT11C0014859Esophageal Neoplasms1CTD_human
HgeneTRMT11C0017636Glioblastoma1CTD_human
HgeneTRMT11C0023903Liver neoplasms1CTD_human
HgeneTRMT11C0024232Lymphatic Metastasis1CTD_human
HgeneTRMT11C0334588Giant Cell Glioblastoma1CTD_human
HgeneTRMT11C0345904Malignant neoplasm of liver1CTD_human
HgeneTRMT11C0546837Malignant neoplasm of esophagus1CTD_human
HgeneTRMT11C0678222Breast Carcinoma1CTD_human
HgeneTRMT11C0919267ovarian neoplasm1CTD_human
HgeneTRMT11C1140680Malignant neoplasm of ovary1CTD_human
HgeneTRMT11C1257931Mammary Neoplasms, Human1CTD_human
HgeneTRMT11C1458155Mammary Neoplasms1CTD_human
HgeneTRMT11C1621958Glioblastoma Multiforme1CTD_human
HgeneTRMT11C4704874Mammary Carcinoma, Human1CTD_human
TgeneNCOA7C0033578Prostatic Neoplasms1CTD_human
TgeneNCOA7C0376358Malignant neoplasm of prostate1CTD_human