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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TRMU-ATXN10 (FusionGDB2 ID:93658)

Fusion Gene Summary for TRMU-ATXN10

check button Fusion gene summary
Fusion gene informationFusion gene name: TRMU-ATXN10
Fusion gene ID: 93658
HgeneTgene
Gene symbol

TRMU

ATXN10

Gene ID

55687

25814

Gene nametRNA 5-methylaminomethyl-2-thiouridylate methyltransferaseataxin 10
SynonymsLCAL3|MTO2|MTU1|TRMT|TRMT1E46L|HUMEEP|SCA10
Cytomap

22q13.31

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial tRNA-specific 2-thiouridylase 1MTO2 homologlung cancer associated lncRNA 3mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferaseataxin-10brain protein E46 homologspinocerebellar ataxia type 10 protein
Modification date2020031320200313
UniProtAcc.

Q9UBB4

Ensembl transtripts involved in fusion geneENST00000476901, ENST00000290846, 
ENST00000381019, ENST00000424260, 
ENST00000381061, ENST00000252934, 
ENST00000498009, ENST00000402380, 
Fusion gene scores* DoF score11 X 8 X 10=88024 X 19 X 12=5472
# samples 1628
** MAII scorelog2(16/880*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/5472*10)=-4.28856949794093
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRMU [Title/Abstract] AND ATXN10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTRMU(46739265)-ATXN10(46085592), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATXN10

GO:0031175

neuron projection development

16498633


check buttonFusion gene breakpoints across TRMU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ATXN10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-RD-A8MW-01ATRMUchr22

46739265

+ATXN10chr22

46085592

+
ChimerDB4STADTCGA-RD-A8MW-01ATRMUchr22

46739265

+ATXN10chr22

46085592

+
ChimerDB4STADTCGA-RD-A8MW-01ATRMUchr22

46733841

+ATXN10chr22

46085592

+
ChimerDB4STADTCGA-RD-A8MW-01ATRMUchr22

46733841

+ATXN10chr22

46088876

+
ChimerDB4STADTCGA-RD-A8MW-01ATRMUchr22

46739265

-ATXN10chr22

46085592

+


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Fusion Gene ORF analysis for TRMU-ATXN10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000476901ENST00000381061TRMUchr22

46739265

+ATXN10chr22

46085592

+
intron-intronENST00000476901ENST00000252934TRMUchr22

46739265

+ATXN10chr22

46085592

+
intron-3UTRENST00000476901ENST00000498009TRMUchr22

46739265

+ATXN10chr22

46085592

+
intron-intronENST00000476901ENST00000402380TRMUchr22

46739265

+ATXN10chr22

46085592

+
5CDS-intronENST00000290846ENST00000381061TRMUchr22

46739265

+ATXN10chr22

46085592

+
5CDS-intronENST00000290846ENST00000252934TRMUchr22

46739265

+ATXN10chr22

46085592

+
5CDS-3UTRENST00000290846ENST00000498009TRMUchr22

46739265

+ATXN10chr22

46085592

+
5CDS-intronENST00000290846ENST00000402380TRMUchr22

46739265

+ATXN10chr22

46085592

+
5CDS-intronENST00000381019ENST00000381061TRMUchr22

46739265

+ATXN10chr22

46085592

+
5CDS-intronENST00000381019ENST00000252934TRMUchr22

46739265

+ATXN10chr22

46085592

+
5CDS-3UTRENST00000381019ENST00000498009TRMUchr22

46739265

+ATXN10chr22

46085592

+
5CDS-intronENST00000381019ENST00000402380TRMUchr22

46739265

+ATXN10chr22

46085592

+
5CDS-intronENST00000424260ENST00000381061TRMUchr22

46739265

+ATXN10chr22

46085592

+
5CDS-intronENST00000424260ENST00000252934TRMUchr22

46739265

+ATXN10chr22

46085592

+
5CDS-3UTRENST00000424260ENST00000498009TRMUchr22

46739265

+ATXN10chr22

46085592

+
5CDS-intronENST00000424260ENST00000402380TRMUchr22

46739265

+ATXN10chr22

46085592

+
intron-intronENST00000476901ENST00000381061TRMUchr22

46733841

+ATXN10chr22

46085592

+
intron-intronENST00000476901ENST00000252934TRMUchr22

46733841

+ATXN10chr22

46085592

+
intron-3UTRENST00000476901ENST00000498009TRMUchr22

46733841

+ATXN10chr22

46085592

+
intron-intronENST00000476901ENST00000402380TRMUchr22

46733841

+ATXN10chr22

46085592

+
5CDS-intronENST00000290846ENST00000381061TRMUchr22

46733841

+ATXN10chr22

46085592

+
5CDS-intronENST00000290846ENST00000252934TRMUchr22

46733841

+ATXN10chr22

46085592

+
5CDS-3UTRENST00000290846ENST00000498009TRMUchr22

46733841

+ATXN10chr22

46085592

+
5CDS-intronENST00000290846ENST00000402380TRMUchr22

46733841

+ATXN10chr22

46085592

+
5CDS-intronENST00000381019ENST00000381061TRMUchr22

46733841

+ATXN10chr22

46085592

+
5CDS-intronENST00000381019ENST00000252934TRMUchr22

46733841

+ATXN10chr22

46085592

+
5CDS-3UTRENST00000381019ENST00000498009TRMUchr22

46733841

+ATXN10chr22

46085592

+
5CDS-intronENST00000381019ENST00000402380TRMUchr22

46733841

+ATXN10chr22

46085592

+
5CDS-intronENST00000424260ENST00000381061TRMUchr22

46733841

+ATXN10chr22

46085592

+
5CDS-intronENST00000424260ENST00000252934TRMUchr22

46733841

+ATXN10chr22

46085592

+
5CDS-3UTRENST00000424260ENST00000498009TRMUchr22

46733841

+ATXN10chr22

46085592

+
5CDS-intronENST00000424260ENST00000402380TRMUchr22

46733841

+ATXN10chr22

46085592

+
intron-3CDSENST00000476901ENST00000381061TRMUchr22

46733841

+ATXN10chr22

46088876

+
intron-3CDSENST00000476901ENST00000252934TRMUchr22

46733841

+ATXN10chr22

46088876

+
intron-3UTRENST00000476901ENST00000498009TRMUchr22

46733841

+ATXN10chr22

46088876

+
intron-intronENST00000476901ENST00000402380TRMUchr22

46733841

+ATXN10chr22

46088876

+
In-frameENST00000290846ENST00000381061TRMUchr22

46733841

+ATXN10chr22

46088876

+
In-frameENST00000290846ENST00000252934TRMUchr22

46733841

+ATXN10chr22

46088876

+
5CDS-3UTRENST00000290846ENST00000498009TRMUchr22

46733841

+ATXN10chr22

46088876

+
5CDS-intronENST00000290846ENST00000402380TRMUchr22

46733841

+ATXN10chr22

46088876

+
In-frameENST00000381019ENST00000381061TRMUchr22

46733841

+ATXN10chr22

46088876

+
In-frameENST00000381019ENST00000252934TRMUchr22

46733841

+ATXN10chr22

46088876

+
5CDS-3UTRENST00000381019ENST00000498009TRMUchr22

46733841

+ATXN10chr22

46088876

+
5CDS-intronENST00000381019ENST00000402380TRMUchr22

46733841

+ATXN10chr22

46088876

+
In-frameENST00000424260ENST00000381061TRMUchr22

46733841

+ATXN10chr22

46088876

+
In-frameENST00000424260ENST00000252934TRMUchr22

46733841

+ATXN10chr22

46088876

+
5CDS-3UTRENST00000424260ENST00000498009TRMUchr22

46733841

+ATXN10chr22

46088876

+
5CDS-intronENST00000424260ENST00000402380TRMUchr22

46733841

+ATXN10chr22

46088876

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000290846TRMUchr2246733841+ENST00000381061ATXN10chr2246088876+33415883101707465
ENST00000290846TRMUchr2246733841+ENST00000252934ATXN10chr2246088876+33445883101707465
ENST00000381019TRMUchr2246733841+ENST00000381061ATXN10chr2246088876+302126851387460
ENST00000381019TRMUchr2246733841+ENST00000252934ATXN10chr2246088876+302426851387460
ENST00000424260TRMUchr2246733841+ENST00000381061ATXN10chr2246088876+31043512081470420
ENST00000424260TRMUchr2246733841+ENST00000252934ATXN10chr2246088876+31073512081470420

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000290846ENST00000381061TRMUchr2246733841+ATXN10chr2246088876+0.0003285650.99967146
ENST00000290846ENST00000252934TRMUchr2246733841+ATXN10chr2246088876+0.0003264810.9996735
ENST00000381019ENST00000381061TRMUchr2246733841+ATXN10chr2246088876+0.0002520660.99974793
ENST00000381019ENST00000252934TRMUchr2246733841+ATXN10chr2246088876+0.0002500490.99974996
ENST00000424260ENST00000381061TRMUchr2246733841+ATXN10chr2246088876+0.0003715250.9996284
ENST00000424260ENST00000252934TRMUchr2246733841+ATXN10chr2246088876+0.0003674360.9996326

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Fusion Genomic Features for TRMU-ATXN10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TRMUchr2246733841+ATXN10chr2246085591+0.087984430.91201556
TRMUchr2246733841+ATXN10chr2246088875+0.009203360.99079657
TRMUchr2246739265+ATXN10chr2246085591+0.0027031270.99729687
TRMUchr2246733841+ATXN10chr2246085591+0.087984430.91201556
TRMUchr2246733841+ATXN10chr2246088875+0.009203360.99079657
TRMUchr2246739265+ATXN10chr2246085591+0.0027031270.99729687

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TRMU-ATXN10


check button Go to

FGviewer for the breakpoints of chr22:46733841-chr22:46088876

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ATXN10

Q9UBB4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRMUchr22:46733841chr22:46088876ENST00000290846+21110_1782.66666666666667422.0Nucleotide bindingATP
HgeneTRMUchr22:46733841chr22:46088876ENST00000381019+21010_1782.66666666666667377.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TRMU-ATXN10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000290846_ENST00000381061_TCGA-RD-A8MW-01A_TRMU_chr22_46733841_+_ATXN10_chr22_46088876_length(transcript)=3341nt_BP=588nt
GGCTGGGGGGCTTAGAATTTTATTTTTGGTTTACAGCGCAGAAGAAGAGCAGTGAGGCCGGGGCGCGGGTGGGGAGGGCAAGGCGGCGGC
TCAAAAAAAAAGCCAGCCCCTCGCGGCCCGACAGAGTCTCGGCGCCCCGCGGGTCGGTGGAGCCTCAGGGGTGAGCGCAGGCCGGAGACA
GGGGAACCCGCCGCGGGACAGGGGAAGGCCGGACGGAACGCGGGTAAGCTGCCGCAGCTTCCGGCCGGGCCACTAGCGCGGACCCTACGG
CCGGGGCGGGACTTCCGGCAAGGCGCGGAAGCGGCGGTAGCTGCAGCTGGCGAAGTTGGGCGACTGGCGGATGCAGGCCTTGCGGCACGT
CGTGTGCGCCCTGTCCGGCGGCGTGGACAGCGCCGTGGCCGCGCTGCTGCTGAGGCGGAGAGGTTACCAGGTGACAGGGGTGTTTATGAA
GAACTGGGACTCACTGGATGAACATGGGGTCTGTACTGCCGACAAAGACTGTGAAGATGCTTACAGAGTTTGCCAGATCTTAGACATCCC
TTTCCATCAAGTGTCCTACGTAAAGGAGTATTGGAATGATGTGTTCAGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCT
GTTTCGTGAACTGCGAGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGA
AGATTCCCAGTCTATTGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTC
TTCAATGATTTTGTTTACATCCCTTAATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTA
CCAAAAACATCCTGAATCAGAATGGCCGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAA
ACTGAACAATCAAGAAAGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGT
GTTTTTGCGGCATGCTGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGA
TGAGGAGGCACTGGCTACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCC
TGGCTTGCTGGAAAGAGTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGT
GAGAGCAGAAGGTGACATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGA
TAACCAAGACAAGGTAAATGAGCTGGATGGTATCCCGTTGATCCTGGACAACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTG
GGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGC
ATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAAT
GAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTT
ATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTG
TTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGC
AGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAG
TCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGC
AATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGT
ACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCAT
GTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCAT
GGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCT
CATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATC
TGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCA
TATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATA
TCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCA
AATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCC
ATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTT
ATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTG
TCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCC
TGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAGCTATATAATAACAAACACAAATAAATAAAAGGGAGC

>In-frame_ENST00000290846_ENST00000381061_TCGA-RD-A8MW-01A_TRMU_chr22_46733841_+_ATXN10_chr22_46088876_length(amino acids)=465AA_start in transcript=310_stop in transcript=1707
MQLAKLGDWRMQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWND
VFRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERM
KELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFV
DQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGF
KSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKK

--------------------------------------------------------------
>In-frame_ENST00000290846_ENST00000252934_TCGA-RD-A8MW-01A_TRMU_chr22_46733841_+_ATXN10_chr22_46088876_length(transcript)=3344nt_BP=588nt
GGCTGGGGGGCTTAGAATTTTATTTTTGGTTTACAGCGCAGAAGAAGAGCAGTGAGGCCGGGGCGCGGGTGGGGAGGGCAAGGCGGCGGC
TCAAAAAAAAAGCCAGCCCCTCGCGGCCCGACAGAGTCTCGGCGCCCCGCGGGTCGGTGGAGCCTCAGGGGTGAGCGCAGGCCGGAGACA
GGGGAACCCGCCGCGGGACAGGGGAAGGCCGGACGGAACGCGGGTAAGCTGCCGCAGCTTCCGGCCGGGCCACTAGCGCGGACCCTACGG
CCGGGGCGGGACTTCCGGCAAGGCGCGGAAGCGGCGGTAGCTGCAGCTGGCGAAGTTGGGCGACTGGCGGATGCAGGCCTTGCGGCACGT
CGTGTGCGCCCTGTCCGGCGGCGTGGACAGCGCCGTGGCCGCGCTGCTGCTGAGGCGGAGAGGTTACCAGGTGACAGGGGTGTTTATGAA
GAACTGGGACTCACTGGATGAACATGGGGTCTGTACTGCCGACAAAGACTGTGAAGATGCTTACAGAGTTTGCCAGATCTTAGACATCCC
TTTCCATCAAGTGTCCTACGTAAAGGAGTATTGGAATGATGTGTTCAGGAACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCT
GTTTCGTGAACTGCGAGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGA
AGATTCCCAGTCTATTGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTC
TTCAATGATTTTGTTTACATCCCTTAATCATGAAAGAATGAAAGAACTGGAGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTA
CCAAAAACATCCTGAATCAGAATGGCCGTTCTTGATTATTACAGACCTCTTTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAA
ACTGAACAATCAAGAAAGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGT
GTTTTTGCGGCATGCTGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGA
TGAGGAGGCACTGGCTACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCC
TGGCTTGCTGGAAAGAGTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGT
GAGAGCAGAAGGTGACATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGA
TAACCAAGACAAGGTAAATGAGCTGGATGGTATCCCGTTGATCCTGGACAACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTG
GGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGC
ATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAAT
GAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTT
ATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTG
TTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGC
AGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAG
TCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGC
AATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGT
ACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCAT
GTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCAT
GGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCT
CATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATC
TGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCA
TATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATA
TCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCA
AATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCC
ATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTT
ATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTG
TCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCC
TGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAGCTATATAATAACAAACACAAATAAATAAAAGGGAGC

>In-frame_ENST00000290846_ENST00000252934_TCGA-RD-A8MW-01A_TRMU_chr22_46733841_+_ATXN10_chr22_46088876_length(amino acids)=465AA_start in transcript=310_stop in transcript=1707
MQLAKLGDWRMQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWND
VFRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERM
KELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFV
DQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGF
KSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKK

--------------------------------------------------------------
>In-frame_ENST00000381019_ENST00000381061_TCGA-RD-A8MW-01A_TRMU_chr22_46733841_+_ATXN10_chr22_46088876_length(transcript)=3021nt_BP=268nt
CGAAGTTGGGCGACTGGCGGATGCAGGCCTTGCGGCACGTCGTGTGCGCCCTGTCCGGCGGCGTGGACAGCGCCGTGGCCGCGCTGCTGC
TGAGGCGGAGAGGTTACCAGGTGACAGGGGTGTTTATGAAGAACTGGGACTCACTGGATGAACATGGGGTCTGTACTGCCGACAAAGACT
GTGAAGATGCTTACAGAGTTTGCCAGATCTTAGACATCCCTTTCCATCAAGTGTCCTACGTAAAGGAGTATTGGAATGATGTGTTCAGGA
ACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCGAGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCT
GTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTATTGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGT
CTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTTTACATCCCTTAATCATGAAAGAATGAAAGAACTGG
AGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGAATCAGAATGGCCGTTCTTGATTATTACAGACCTCT
TTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAAAGAGTTACACTGTTAGACCTTATGATAGCCAAGA
TAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCTGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCA
AGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCTACAATTAGGCTTCTCGACGTCCTGTGCGAAATGA
CTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGAGTGATTGATCTTTTGCGGGTGATTCATGTAGCTG
GAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGACATCTCCAATGTGGCCAATGGGTTTAAGTCTCATC
TCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGTAAATGAGCTGGATGGTATCCCGTTGATCCTGGACA
ACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAG
ATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGC
TGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTC
ATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAAC
GTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAG
AACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTT
GGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGG
CAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTC
CAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAG
TGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAG
GTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAA
GGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAG
TACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTG
GATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAAC
ATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAG
ACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAA
AATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTA
GGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAA
GGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTT
TCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTA

>In-frame_ENST00000381019_ENST00000381061_TCGA-RD-A8MW-01A_TRMU_chr22_46733841_+_ATXN10_chr22_46088876_length(amino acids)=460AA_start in transcript=5_stop in transcript=1387
MGDWRMQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFRNL
DTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEE
NLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKT
VLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLI
RLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLI

--------------------------------------------------------------
>In-frame_ENST00000381019_ENST00000252934_TCGA-RD-A8MW-01A_TRMU_chr22_46733841_+_ATXN10_chr22_46088876_length(transcript)=3024nt_BP=268nt
CGAAGTTGGGCGACTGGCGGATGCAGGCCTTGCGGCACGTCGTGTGCGCCCTGTCCGGCGGCGTGGACAGCGCCGTGGCCGCGCTGCTGC
TGAGGCGGAGAGGTTACCAGGTGACAGGGGTGTTTATGAAGAACTGGGACTCACTGGATGAACATGGGGTCTGTACTGCCGACAAAGACT
GTGAAGATGCTTACAGAGTTTGCCAGATCTTAGACATCCCTTTCCATCAAGTGTCCTACGTAAAGGAGTATTGGAATGATGTGTTCAGGA
ACTTGGATACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCGAGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCT
GTGGCCTGCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTATTGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGT
CTTGCTTAAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTTTACATCCCTTAATCATGAAAGAATGAAAGAACTGG
AGGAGAACCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGAATCAGAATGGCCGTTCTTGATTATTACAGACCTCT
TTCTGAAAAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAAAGAGTTACACTGTTAGACCTTATGATAGCCAAGA
TAACGAGTGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCTGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCA
AGACTGTGCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCTACAATTAGGCTTCTCGACGTCCTGTGCGAAATGA
CTGTGAATACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGAGTGATTGATCTTTTGCGGGTGATTCATGTAGCTG
GAAAAGAAACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGACATCTCCAATGTGGCCAATGGGTTTAAGTCTCATC
TCATTCGTCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGTAAATGAGCTGGATGGTATCCCGTTGATCCTGGACA
ACTGCAACATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAG
ATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGC
TGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTC
ATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAAC
GTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAG
AACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTT
GGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGG
CAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTC
CAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAG
TGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAG
GTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAA
GGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAG
TACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTG
GATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAAC
ATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAG
ACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAA
AATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTA
GGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAA
GGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTT
TCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTA

>In-frame_ENST00000381019_ENST00000252934_TCGA-RD-A8MW-01A_TRMU_chr22_46733841_+_ATXN10_chr22_46088876_length(amino acids)=460AA_start in transcript=5_stop in transcript=1387
MGDWRMQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFRNL
DTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEE
NLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKT
VLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLI
RLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLI

--------------------------------------------------------------
>In-frame_ENST00000424260_ENST00000381061_TCGA-RD-A8MW-01A_TRMU_chr22_46733841_+_ATXN10_chr22_46088876_length(transcript)=3104nt_BP=351nt
GTGCACGTCTCCTCCCTCCCTGGGCCGCTGGTTGCGCGCGGGTCGGCAGGAGGATACCCCGTCCTCTGACTTTGGTTCGGAGGCTCCTCG
CCCTCCACCTGTGTAGTCGGAGGTGTGCGCGACTGCAGCTCCGACTACCTGGGAGCAGTTCCGCGCCCCTCTCCACCCACGCGCGCCCAC
CCACAGTTACCAGGTGACAGGGGTGTTTATGAAGAACTGGGACTCACTGGATGAACATGGGGTCTGTACTGCCGACAAAGACTGTGAAGA
TGCTTACAGAGTTTGCCAGATCTTAGACATCCCTTTCCATCAAGTGTCCTACGTAAAGGAGTATTGGAATGATGTGTTCAGGAACTTGGA
TACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCGAGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCT
GCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTATTGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTT
AAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTTTACATCCCTTAATCATGAAAGAATGAAAGAACTGGAGGAGAA
CCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGAATCAGAATGGCCGTTCTTGATTATTACAGACCTCTTTCTGAA
AAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAAAGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAG
TGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCTGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGT
GCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCTACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAA
TACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGAGTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGA
AACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGACATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCG
TCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGTAAATGAGCTGGATGGTATCCCGTTGATCCTGGACAACTGCAA
CATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGAT
TGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCT
GAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCT
ACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATA
AGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGC
ATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTT
GGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGG
TTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAA
TTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTT
GGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATG
CCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACAT
TTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTT
AGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAA
TGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTAT
TTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTC
CAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCT
TAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGC
AGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCA
TTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTT
TAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAGCTA

>In-frame_ENST00000424260_ENST00000381061_TCGA-RD-A8MW-01A_TRMU_chr22_46733841_+_ATXN10_chr22_46088876_length(amino acids)=420AA_start in transcript=208_stop in transcript=1470
MKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASR
NEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMF
PKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQV
FPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLT

--------------------------------------------------------------
>In-frame_ENST00000424260_ENST00000252934_TCGA-RD-A8MW-01A_TRMU_chr22_46733841_+_ATXN10_chr22_46088876_length(transcript)=3107nt_BP=351nt
GTGCACGTCTCCTCCCTCCCTGGGCCGCTGGTTGCGCGCGGGTCGGCAGGAGGATACCCCGTCCTCTGACTTTGGTTCGGAGGCTCCTCG
CCCTCCACCTGTGTAGTCGGAGGTGTGCGCGACTGCAGCTCCGACTACCTGGGAGCAGTTCCGCGCCCCTCTCCACCCACGCGCGCCCAC
CCACAGTTACCAGGTGACAGGGGTGTTTATGAAGAACTGGGACTCACTGGATGAACATGGGGTCTGTACTGCCGACAAAGACTGTGAAGA
TGCTTACAGAGTTTGCCAGATCTTAGACATCCCTTTCCATCAAGTGTCCTACGTAAAGGAGTATTGGAATGATGTGTTCAGGAACTTGGA
TACGATTGGTGTTGCTGTTGATTTGATTCTTCTGTTTCGTGAACTGCGAGTGGAACAGGAATCTCTGTTGACAGCTTTTCGCTGTGGCCT
GCAGTTTTTAGGCAACATTGCCTCACGGAATGAAGATTCCCAGTCTATTGTTTGGGTGCATGCTTTCCCAGAACTGTTTTTGTCTTGCTT
AAATCATCCGGACAAAAAAATTGTTGCCTACTCTTCAATGATTTTGTTTACATCCCTTAATCATGAAAGAATGAAAGAACTGGAGGAGAA
CCTCAATATTGCAATTGATGTCATAGATGCTTACCAAAAACATCCTGAATCAGAATGGCCGTTCTTGATTATTACAGACCTCTTTCTGAA
AAGCCCGGAATTGGTACAAGCCATGTTTCCCAAACTGAACAATCAAGAAAGAGTTACACTGTTAGACCTTATGATAGCCAAGATAACGAG
TGATGAGCCACTCACCAAGGATGACATCCCTGTGTTTTTGCGGCATGCTGAGTTGATTGCAAGCACCTTTGTGGATCAGTGCAAGACTGT
GCTCAAGCTGGCCTCTGAGGAGCCTCCTGATGATGAGGAGGCACTGGCTACAATTAGGCTTCTCGACGTCCTGTGCGAAATGACTGTGAA
TACTGAGCTGCTCGGCTATCTGCAGGTTTTCCCTGGCTTGCTGGAAAGAGTGATTGATCTTTTGCGGGTGATTCATGTAGCTGGAAAAGA
AACCACAAACATCTTCAGTAATTGTGGTTGCGTGAGAGCAGAAGGTGACATCTCCAATGTGGCCAATGGGTTTAAGTCTCATCTCATTCG
TCTGATTGGAAATCTGTGTTACAAGAATAAAGATAACCAAGACAAGGTAAATGAGCTGGATGGTATCCCGTTGATCCTGGACAACTGCAA
CATCAGTGACAGTAACCCCTTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGAT
TGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCT
GAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCT
ACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATA
AGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGC
ATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTT
GGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGG
TTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAA
TTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTT
GGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATG
CCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACAT
TTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTT
AGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAA
TGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTAT
TTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTC
CAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCT
TAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGC
AGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCA
TTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTT
TAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAGCTA

>In-frame_ENST00000424260_ENST00000252934_TCGA-RD-A8MW-01A_TRMU_chr22_46733841_+_ATXN10_chr22_46088876_length(amino acids)=420AA_start in transcript=208_stop in transcript=1470
MKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFRNLDTIGVAVDLILLFRELRVEQESLLTAFRCGLQFLGNIASR
NEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMILFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMF
PKLNNQERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEALATIRLLDVLCEMTVNTELLGYLQV
FPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAEGDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLT

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Fusion Gene PPI Analysis for TRMU-ATXN10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTRMUchr22:46733841chr22:46088876ENST00000290846+21196_9882.66666666666667422.0target base in tRNA
HgeneTRMUchr22:46733841chr22:46088876ENST00000381019+21096_9882.66666666666667377.0target base in tRNA
HgeneTRMUchr22:46733841chr22:46088876ENST00000290846+211171_17382.66666666666667422.0tRNA
HgeneTRMUchr22:46733841chr22:46088876ENST00000290846+211334_33582.66666666666667422.0tRNA
HgeneTRMUchr22:46733841chr22:46088876ENST00000381019+210171_17382.66666666666667377.0tRNA
HgeneTRMUchr22:46733841chr22:46088876ENST00000381019+210334_33582.66666666666667377.0tRNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TRMU-ATXN10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TRMU-ATXN10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRMUC3278664LIVER FAILURE, INFANTILE, TRANSIENT3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTRMUC1838854DEAFNESS, AMINOGLYCOSIDE-INDUCED1CTD_human;GENOMICS_ENGLAND
HgeneTRMUC1857332Deafness, Sensorineural, Autosomal-Mitochondrial Type1ORPHANET
HgeneTRMUC3151898MITOCHONDRIAL MYOPATHY, INFANTILE, TRANSIENT1ORPHANET
TgeneATXN10C0687120Nephronophthisis1GENOMICS_ENGLAND
TgeneATXN10C1963674Spinocerebellar Ataxia 101CTD_human;GENOMICS_ENGLAND;ORPHANET