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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TSEN2-KLK2 (FusionGDB2 ID:93876)

Fusion Gene Summary for TSEN2-KLK2

Fusion gene summary

Fusion gene information	Fusion gene name: TSEN2-KLK2
	Fusion gene ID: 93876
		Hgene	Tgene
	Gene symbol	TSEN2	KLK2
	Gene ID	80746	3817
	Gene name	tRNA splicing endonuclease subunit 2	kallikrein related peptidase 2
	Synonyms	PCH2B\|SEN2\|SEN2L	KLK2A2\|hGK-1\|hK2
	Cytomap	3p25.2	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	tRNA-splicing endonuclease subunit Sen2TSEN2 tRNA splicing endonuclease subunithsSen2tRNA-intron endonuclease Sen2	kallikrein-2glandular kallikrein 2glandular kallikrein-1kallikrein 2, prostatictissue kallikrein-2
	Modification date	20200313	20200313
	UniProtAcc	.	P20151
	Ensembl transtripts involved in fusion gene	ENST00000314571, ENST00000383797, ENST00000454502, ENST00000402228, ENST00000444864, ENST00000284995, ENST00000415684, ENST00000475595,	ENST00000325321, ENST00000391810, ENST00000358049, ENST00000597509,
Fusion gene scores	* DoF score	7 X 12 X 4=336	15 X 20 X 2=600
	# samples	13	21
	** MAII score	log2(13/336*10)=-1.36994960975031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/600*10)=-1.51457317282976 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TSEN2 [Title/Abstract] AND KLK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TSEN2(12533716)-KLK2(51379728), # samples:1 TSEN2(12533716)-KLK2(51377977), # samples:1 TSEN2(12533590)-KLK2(51377976), # samples:1 TSEN2(12533590)-KLK2(51379727), # samples:1 TSEN2(12533715)-KLK2(51379727), # samples:1
Anticipated loss of major functional domain due to fusion event.	TSEN2-KLK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TSEN2-KLK2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. TSEN2-KLK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TSEN2	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	17495927

Fusion gene breakpoints across TSEN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KLK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-G9-6378	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
ChimerDB4	PRAD	TCGA-G9-6378	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
ChimerDB4	PRAD	TCGA-G9-6378-01A	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
ChimerDB4	PRAD	TCGA-G9-6378-01A	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
ChimerDB4	PRAD	TCGA-G9-6378-01A	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+

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Fusion Gene ORF analysis for TSEN2-KLK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000314571	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000314571	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000314571	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-3UTR	ENST00000314571	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
Frame-shift	ENST00000383797	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000383797	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000383797	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-3UTR	ENST00000383797	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
Frame-shift	ENST00000454502	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000454502	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000454502	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-3UTR	ENST00000454502	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
Frame-shift	ENST00000402228	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000402228	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000402228	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-3UTR	ENST00000402228	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
Frame-shift	ENST00000444864	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000444864	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000444864	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-3UTR	ENST00000444864	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
Frame-shift	ENST00000284995	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000284995	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000284995	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-3UTR	ENST00000284995	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
Frame-shift	ENST00000415684	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000415684	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-5UTR	ENST00000415684	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
5CDS-3UTR	ENST00000415684	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
intron-3CDS	ENST00000475595	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
intron-5UTR	ENST00000475595	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
intron-5UTR	ENST00000475595	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
intron-3UTR	ENST00000475595	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51379728	+
In-frame	ENST00000314571	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000314571	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000314571	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-3UTR	ENST00000314571	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
In-frame	ENST00000383797	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000383797	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000383797	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-3UTR	ENST00000383797	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
In-frame	ENST00000454502	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000454502	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000454502	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-3UTR	ENST00000454502	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
In-frame	ENST00000402228	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000402228	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000402228	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-3UTR	ENST00000402228	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
In-frame	ENST00000444864	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000444864	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000444864	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-3UTR	ENST00000444864	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
In-frame	ENST00000284995	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000284995	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000284995	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-3UTR	ENST00000284995	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
In-frame	ENST00000415684	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000415684	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-intron	ENST00000415684	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
5CDS-3UTR	ENST00000415684	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
intron-3CDS	ENST00000475595	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
intron-intron	ENST00000475595	ENST00000391810	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
intron-intron	ENST00000475595	ENST00000358049	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
intron-3UTR	ENST00000475595	ENST00000597509	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+
intron-3CDS	ENST00000314571	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000314571	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000314571	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3UTR	ENST00000314571	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3CDS	ENST00000383797	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000383797	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000383797	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3UTR	ENST00000383797	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3CDS	ENST00000454502	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000454502	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000454502	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3UTR	ENST00000454502	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3CDS	ENST00000402228	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000402228	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000402228	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3UTR	ENST00000402228	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3CDS	ENST00000444864	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000444864	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000444864	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3UTR	ENST00000444864	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3CDS	ENST00000284995	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000284995	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000284995	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3UTR	ENST00000284995	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3CDS	ENST00000415684	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000415684	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000415684	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3UTR	ENST00000415684	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3CDS	ENST00000475595	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000475595	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-intron	ENST00000475595	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3UTR	ENST00000475595	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51377976	+
intron-3CDS	ENST00000314571	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000314571	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000314571	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3UTR	ENST00000314571	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3CDS	ENST00000383797	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000383797	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000383797	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3UTR	ENST00000383797	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3CDS	ENST00000454502	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000454502	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000454502	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3UTR	ENST00000454502	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3CDS	ENST00000402228	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000402228	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000402228	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3UTR	ENST00000402228	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3CDS	ENST00000444864	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000444864	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000444864	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3UTR	ENST00000444864	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3CDS	ENST00000284995	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000284995	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000284995	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3UTR	ENST00000284995	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3CDS	ENST00000415684	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000415684	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000415684	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3UTR	ENST00000415684	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3CDS	ENST00000475595	ENST00000325321	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000475595	ENST00000391810	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000475595	ENST00000358049	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
intron-3UTR	ENST00000475595	ENST00000597509	TSEN2	chr3	12533590	+	KLK2	chr19	51379727	+
Frame-shift	ENST00000314571	ENST00000325321	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000314571	ENST00000391810	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000314571	ENST00000358049	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-3UTR	ENST00000314571	ENST00000597509	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
Frame-shift	ENST00000383797	ENST00000325321	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000383797	ENST00000391810	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000383797	ENST00000358049	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-3UTR	ENST00000383797	ENST00000597509	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
Frame-shift	ENST00000454502	ENST00000325321	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000454502	ENST00000391810	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000454502	ENST00000358049	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-3UTR	ENST00000454502	ENST00000597509	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
Frame-shift	ENST00000402228	ENST00000325321	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000402228	ENST00000391810	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000402228	ENST00000358049	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-3UTR	ENST00000402228	ENST00000597509	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
Frame-shift	ENST00000444864	ENST00000325321	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000444864	ENST00000391810	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000444864	ENST00000358049	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-3UTR	ENST00000444864	ENST00000597509	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
Frame-shift	ENST00000284995	ENST00000325321	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000284995	ENST00000391810	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000284995	ENST00000358049	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-3UTR	ENST00000284995	ENST00000597509	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
Frame-shift	ENST00000415684	ENST00000325321	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000415684	ENST00000391810	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-5UTR	ENST00000415684	ENST00000358049	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
5CDS-3UTR	ENST00000415684	ENST00000597509	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
intron-3CDS	ENST00000475595	ENST00000325321	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000475595	ENST00000391810	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
intron-5UTR	ENST00000475595	ENST00000358049	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+
intron-3UTR	ENST00000475595	ENST00000597509	TSEN2	chr3	12533715	+	KLK2	chr19	51379727	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000314571	TSEN2	chr3	12533716	+	ENST00000325321	KLK2	chr19	51377977	+	3122	374	103	1113	336
ENST00000383797	TSEN2	chr3	12533716	+	ENST00000325321	KLK2	chr19	51377977	+	3111	363	92	1102	336
ENST00000454502	TSEN2	chr3	12533716	+	ENST00000325321	KLK2	chr19	51377977	+	3111	363	92	1102	336
ENST00000402228	TSEN2	chr3	12533716	+	ENST00000325321	KLK2	chr19	51377977	+	3174	426	155	1165	336
ENST00000444864	TSEN2	chr3	12533716	+	ENST00000325321	KLK2	chr19	51377977	+	3406	658	387	1397	336
ENST00000284995	TSEN2	chr3	12533716	+	ENST00000325321	KLK2	chr19	51377977	+	3406	658	387	1397	336
ENST00000415684	TSEN2	chr3	12533716	+	ENST00000325321	KLK2	chr19	51377977	+	3040	292	21	1031	336

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000314571	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+	0.029044073	0.97095597
ENST00000383797	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+	0.028191209	0.9718088
ENST00000454502	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+	0.028191209	0.9718088
ENST00000402228	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+	0.026764065	0.97323596
ENST00000444864	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+	0.02824087	0.97175914
ENST00000284995	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+	0.02824087	0.97175914
ENST00000415684	ENST00000325321	TSEN2	chr3	12533716	+	KLK2	chr19	51377977	+	0.026861439	0.9731386

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Fusion Genomic Features for TSEN2-KLK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TSEN2	chr3	12533716	+	KLK2	chr19	51377976	+	0.85112596	0.14887401
TSEN2	chr3	12533716	+	KLK2	chr19	51379727	+	0.009457033	0.99054295
TSEN2	chr3	12533716	+	KLK2	chr19	51379727	+	0.009457033	0.99054295
TSEN2	chr3	12533716	+	KLK2	chr19	51377976	+	0.85112596	0.14887401
TSEN2	chr3	12533716	+	KLK2	chr19	51379727	+	0.009457033	0.99054295
TSEN2	chr3	12533716	+	KLK2	chr19	51379727	+	0.009457033	0.99054295

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TSEN2-KLK2

Go to
FGviewer for the breakpoints of chr3:12533716-chr19:51377977
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KLK2 P20151
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KLK2

chr3:12533716

chr19:51377977

ENST00000325321

25_258

15.333333333333334

262.0

Domain

Peptidase S1

Tgene

KLK2

chr3:12533716

chr19:51377977

ENST00000358049

25_258

15.333333333333334

224.0

Domain

Peptidase S1

Tgene

KLK2

chr3:12533716

chr19:51377977

ENST00000391810

25_258

160.0

Domain

Peptidase S1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for TSEN2-KLK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000314571_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(transcript)=3122nt_BP=374nt
TTTGCGGCCGCACTGCTTGACGGCAGCGGTGTCCGCCCCACGGCCGGCGTTGCCGGGGTAACGGCGAGCGCGTGGGGCCAAGAAAGAATA
CCTCCTCTGAAAAATGGCAGAAGCAGTTTTCCATGCCCCAAAGAGGAAAAGAAGAGTGTATGAGACTTACGAGTCTCCATTGCCAATCCC
TTTTGGTCAGGACCATGGTCCTCTGAAAGAATTCAAGATATTCCGTGCTGAAATGATTAACAACAATGTGATTGTGAGGAATGCGGAGGA
CATTGAGCAGCTCTATGGGAAAGGTTATTTTGGAAAAGGTATTCTTTCAAGAAGCCGTCCAAGCTTCACAATTTCAGATCCTAAACTGGT
TGCTAAATGGAAAGGTGCCGTGCCCCTCATCCAGTCTCGGATTGTGGGAGGCTGGGAGTGTGAGAAGCATTCCCAACCCTGGCAGGTGGC
TGTGTACAGTCATGGATGGGCACACTGTGGGGGTGTCCTGGTGCACCCCCAGTGGGTGCTCACAGCTGCCCATTGCCTAAAGAAGAATAG
CCAGGTCTGGCTGGGTCGGCACAACCTGTTTGAGCCTGAAGACACAGGCCAGAGGGTCCCTGTCAGCCACAGCTTCCCACACCCGCTCTA
CAATATGAGCCTTCTGAAGCATCAAAGCCTTAGACCAGATGAAGACTCCAGCCATGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCAA
GATCACAGATGTTGTGAAGGTCCTGGGCCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATCGA
ACCAGAGGAGTTCTTGCGCCCCAGGAGTCTTCAGTGTGTGAGCCTCCATCTCCTGTCCAATGACATGTGTGCTAGAGCTTACTCTGAGAA
GGTGACAGAGTTCATGTTGTGTGCTGGGCTCTGGACAGGTGGTAAAGACACTTGTGGGGGTGATTCTGGGGGTCCACTTGTCTGTAATGG
TGTGCTTCAAGGTATCACATCATGGGGCCCTGAGCCATGTGCCCTGCCTGAAAAGCCTGCTGTGTACACCAAGGTGGTGCATTACCGGAA
GTGGATCAAGGACACCATCGCAGCCAACCCCTGAGTGCCCCTGTCCCACCCCTACCTCTAGTAAATTTAAGTCCACCTCACGTTCTGGCA
TCACTTGGCCTTTCTGGATGCTGGACACCTGAAGCTTGGAACTCACCTGGCCGAAGCTCGAGCCTCCTGAGTCCTACTGACCTGTGCTTT
CTGGTGTGGAGTCCAGGGCTGCTAGGAAAAGGAATGGGCAGACACAGGTGTATGCCAATGTTTCTGAAATGGGTATAATTTCGTCCTCTC
CTTCGGAACACTGGCTGTCTCTGAAGACTTCTCGCTCAGTTTCAGTGAGGACACACACAAAGACGTGGGTGACCATGTTGTTTGTGGGGT
GCAGAGATGGGAGGGGTGGGGCCCACCCTGGAAGAGTGGACAGTGACACAAGGTGGACACTCTCTACAGATCACTGAGGATAAGCTGGAG
CCACAATGCATGAGGCACACACACAGCAAGGATGACGCTGTAAACATAGCCCACGCTGTCCTGGGGGCACTGGGAAGCCTAGATAAGGCC
GTGAGCAGAAAGAAGGGGAGGATCCTCCTATGTTGTTGAAGGAGGGACTAGGGGGAGAAACTGAAAGCTGATTAATTACAGGAGGTTTGT
TCAGGTCCCCCAAACCACCGTCAGATTTGATGATTTCCTAGCAGGACTTACAGAAATAAAGAGCTATCATGCTGTGGTTTATTATGGTTT
GTTACATTGATAGGATACATACTGAAATCAGCAAACAAAACAGATGTATAGATTAGAGTGTGGAGAAAACAGAGGAAAACTTGCAGTTAC
GAAGACTGGCAACTTGGCTTTACTAAGTTTTCAGACTGGCAGGAAGTCAAACCTATTAGGCTGAGGACCTTGTGGAGTGTAGCTGATCCA
GCTGATAGAGGAACTAGCCAGGTGGGGGCCTTTCCCTTTGGATGGGGGGCATATCTGACAGTTATTCTCTCCAAGTGGAGACTTACGGAC
AGCATATAATTCTCCCTGCAAGGATGTATGATAATATGTACAAAGTAATTCCAACTGAGGAAGCTCACCTGATCCTTAGTGTCCAGGGTT
TTTACTGGGGGTCTGTAGGACGAGTATGGAGTACTTGAATAATTGACCTGAAGTCCTCAGACCTGAGGTTCCCTAGAGTTCAAACAGATA
CAGCATGGTCCAGAGTCCCAGATGTACAAAAACAGGGATTCATCACAAATCCCATCTTTAGCATGAAGGGTCTGGCATGGCCCAAGGCCC
CAAGTATATCAAGGCACTTGGGCAGAACATGCCAAGGAATCAAATGTCATCTCCCAGGAGTTATTCAAGGGTGAGCCCTTTACTTGGGAT
GTACAGGCTTTGAGCAGTGCAGGGCTGCTGAGTCAACCTTTTATTGTACAGGGGATGAGGGAAAGGGAGAGGATGAGGAAGCCCCCCTGG
GGATTTGGTTTGGTCTTGTGATCAGGTGGTCTATGGGGCTATCCCTACAAAGAAGAATCCAGAAATAGGGGCACATTGAGGAATGATACT
GAGCCCAAAGAGCATTCAATCATTGTTTTATTTGCCTTCTTTTCACACCATTGGTGAGGGAGGGATTACCACCCTGGGGTTATGAAGATG
GTTGAACACCCCACACATAGCACCGGAGATATGAGATCAACAGTTTCTTAGCCATAGAGATTCACAGCCCAGAGCAGGAGGACGCTGCAC
ACCATGCAGGATGACATGGGGGATGCGCTCGGGATTGGTGTGAAGAAGCAAGGACTGTTAGAGGCAGGCTTTATAGTAACAAGACGGTGG
GGCAAACTCTGATTTCCGTGGGGGAATGTCATGGTCTTGCTTTACTAAGTTTTGAGACTGGCAGGTAGTGAAACTCATTAGGCTGAGAAC
CTTGTGGAATGCAGCTGACCCAGCTGATAGAGGAAGTAGCCAGGTGGGAGCCTTTCCCAGTGGGTGTGGGACATATCTGGCAAGATTTTG

>In-frame_ENST00000314571_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(amino acids)=336AA_start in transcript=103_stop in transcript=1113
MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQLYGKGYFGKGILSRSRPSFTISDPKLVAKWK
GAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYNMSL
LKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEF

--------------------------------------------------------------
>In-frame_ENST00000383797_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(transcript)=3111nt_BP=363nt
ACTGCTTGACGGCAGCGGTGTCCGCCCCACGGCCGGCGTTGCCGGGGTAACGGCGAGCGCGTGGGGCCAAGAAAGAATACCTCCTCTGAA
AAATGGCAGAAGCAGTTTTCCATGCCCCAAAGAGGAAAAGAAGAGTGTATGAGACTTACGAGTCTCCATTGCCAATCCCTTTTGGTCAGG
ACCATGGTCCTCTGAAAGAATTCAAGATATTCCGTGCTGAAATGATTAACAACAATGTGATTGTGAGGAATGCGGAGGACATTGAGCAGC
TCTATGGGAAAGGTTATTTTGGAAAAGGTATTCTTTCAAGAAGCCGTCCAAGCTTCACAATTTCAGATCCTAAACTGGTTGCTAAATGGA
AAGGTGCCGTGCCCCTCATCCAGTCTCGGATTGTGGGAGGCTGGGAGTGTGAGAAGCATTCCCAACCCTGGCAGGTGGCTGTGTACAGTC
ATGGATGGGCACACTGTGGGGGTGTCCTGGTGCACCCCCAGTGGGTGCTCACAGCTGCCCATTGCCTAAAGAAGAATAGCCAGGTCTGGC
TGGGTCGGCACAACCTGTTTGAGCCTGAAGACACAGGCCAGAGGGTCCCTGTCAGCCACAGCTTCCCACACCCGCTCTACAATATGAGCC
TTCTGAAGCATCAAAGCCTTAGACCAGATGAAGACTCCAGCCATGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCAAGATCACAGATG
TTGTGAAGGTCCTGGGCCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATCGAACCAGAGGAGT
TCTTGCGCCCCAGGAGTCTTCAGTGTGTGAGCCTCCATCTCCTGTCCAATGACATGTGTGCTAGAGCTTACTCTGAGAAGGTGACAGAGT
TCATGTTGTGTGCTGGGCTCTGGACAGGTGGTAAAGACACTTGTGGGGGTGATTCTGGGGGTCCACTTGTCTGTAATGGTGTGCTTCAAG
GTATCACATCATGGGGCCCTGAGCCATGTGCCCTGCCTGAAAAGCCTGCTGTGTACACCAAGGTGGTGCATTACCGGAAGTGGATCAAGG
ACACCATCGCAGCCAACCCCTGAGTGCCCCTGTCCCACCCCTACCTCTAGTAAATTTAAGTCCACCTCACGTTCTGGCATCACTTGGCCT
TTCTGGATGCTGGACACCTGAAGCTTGGAACTCACCTGGCCGAAGCTCGAGCCTCCTGAGTCCTACTGACCTGTGCTTTCTGGTGTGGAG
TCCAGGGCTGCTAGGAAAAGGAATGGGCAGACACAGGTGTATGCCAATGTTTCTGAAATGGGTATAATTTCGTCCTCTCCTTCGGAACAC
TGGCTGTCTCTGAAGACTTCTCGCTCAGTTTCAGTGAGGACACACACAAAGACGTGGGTGACCATGTTGTTTGTGGGGTGCAGAGATGGG
AGGGGTGGGGCCCACCCTGGAAGAGTGGACAGTGACACAAGGTGGACACTCTCTACAGATCACTGAGGATAAGCTGGAGCCACAATGCAT
GAGGCACACACACAGCAAGGATGACGCTGTAAACATAGCCCACGCTGTCCTGGGGGCACTGGGAAGCCTAGATAAGGCCGTGAGCAGAAA
GAAGGGGAGGATCCTCCTATGTTGTTGAAGGAGGGACTAGGGGGAGAAACTGAAAGCTGATTAATTACAGGAGGTTTGTTCAGGTCCCCC
AAACCACCGTCAGATTTGATGATTTCCTAGCAGGACTTACAGAAATAAAGAGCTATCATGCTGTGGTTTATTATGGTTTGTTACATTGAT
AGGATACATACTGAAATCAGCAAACAAAACAGATGTATAGATTAGAGTGTGGAGAAAACAGAGGAAAACTTGCAGTTACGAAGACTGGCA
ACTTGGCTTTACTAAGTTTTCAGACTGGCAGGAAGTCAAACCTATTAGGCTGAGGACCTTGTGGAGTGTAGCTGATCCAGCTGATAGAGG
AACTAGCCAGGTGGGGGCCTTTCCCTTTGGATGGGGGGCATATCTGACAGTTATTCTCTCCAAGTGGAGACTTACGGACAGCATATAATT
CTCCCTGCAAGGATGTATGATAATATGTACAAAGTAATTCCAACTGAGGAAGCTCACCTGATCCTTAGTGTCCAGGGTTTTTACTGGGGG
TCTGTAGGACGAGTATGGAGTACTTGAATAATTGACCTGAAGTCCTCAGACCTGAGGTTCCCTAGAGTTCAAACAGATACAGCATGGTCC
AGAGTCCCAGATGTACAAAAACAGGGATTCATCACAAATCCCATCTTTAGCATGAAGGGTCTGGCATGGCCCAAGGCCCCAAGTATATCA
AGGCACTTGGGCAGAACATGCCAAGGAATCAAATGTCATCTCCCAGGAGTTATTCAAGGGTGAGCCCTTTACTTGGGATGTACAGGCTTT
GAGCAGTGCAGGGCTGCTGAGTCAACCTTTTATTGTACAGGGGATGAGGGAAAGGGAGAGGATGAGGAAGCCCCCCTGGGGATTTGGTTT
GGTCTTGTGATCAGGTGGTCTATGGGGCTATCCCTACAAAGAAGAATCCAGAAATAGGGGCACATTGAGGAATGATACTGAGCCCAAAGA
GCATTCAATCATTGTTTTATTTGCCTTCTTTTCACACCATTGGTGAGGGAGGGATTACCACCCTGGGGTTATGAAGATGGTTGAACACCC
CACACATAGCACCGGAGATATGAGATCAACAGTTTCTTAGCCATAGAGATTCACAGCCCAGAGCAGGAGGACGCTGCACACCATGCAGGA
TGACATGGGGGATGCGCTCGGGATTGGTGTGAAGAAGCAAGGACTGTTAGAGGCAGGCTTTATAGTAACAAGACGGTGGGGCAAACTCTG
ATTTCCGTGGGGGAATGTCATGGTCTTGCTTTACTAAGTTTTGAGACTGGCAGGTAGTGAAACTCATTAGGCTGAGAACCTTGTGGAATG
CAGCTGACCCAGCTGATAGAGGAAGTAGCCAGGTGGGAGCCTTTCCCAGTGGGTGTGGGACATATCTGGCAAGATTTTGTGGCACTCCTG

>In-frame_ENST00000383797_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(amino acids)=336AA_start in transcript=92_stop in transcript=1102
MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQLYGKGYFGKGILSRSRPSFTISDPKLVAKWK
GAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYNMSL
LKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEF

--------------------------------------------------------------
>In-frame_ENST00000454502_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(transcript)=3111nt_BP=363nt
ACTGCTTGACGGCAGCGGTGTCCGCCCCACGGCCGGCGTTGCCGGGGTAACGGCGAGCGCGTGGGGCCAAGAAAGAATACCTCCTCTGAA
AAATGGCAGAAGCAGTTTTCCATGCCCCAAAGAGGAAAAGAAGAGTGTATGAGACTTACGAGTCTCCATTGCCAATCCCTTTTGGTCAGG
ACCATGGTCCTCTGAAAGAATTCAAGATATTCCGTGCTGAAATGATTAACAACAATGTGATTGTGAGGAATGCGGAGGACATTGAGCAGC
TCTATGGGAAAGGTTATTTTGGAAAAGGTATTCTTTCAAGAAGCCGTCCAAGCTTCACAATTTCAGATCCTAAACTGGTTGCTAAATGGA
AAGGTGCCGTGCCCCTCATCCAGTCTCGGATTGTGGGAGGCTGGGAGTGTGAGAAGCATTCCCAACCCTGGCAGGTGGCTGTGTACAGTC
ATGGATGGGCACACTGTGGGGGTGTCCTGGTGCACCCCCAGTGGGTGCTCACAGCTGCCCATTGCCTAAAGAAGAATAGCCAGGTCTGGC
TGGGTCGGCACAACCTGTTTGAGCCTGAAGACACAGGCCAGAGGGTCCCTGTCAGCCACAGCTTCCCACACCCGCTCTACAATATGAGCC
TTCTGAAGCATCAAAGCCTTAGACCAGATGAAGACTCCAGCCATGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCAAGATCACAGATG
TTGTGAAGGTCCTGGGCCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATCGAACCAGAGGAGT
TCTTGCGCCCCAGGAGTCTTCAGTGTGTGAGCCTCCATCTCCTGTCCAATGACATGTGTGCTAGAGCTTACTCTGAGAAGGTGACAGAGT
TCATGTTGTGTGCTGGGCTCTGGACAGGTGGTAAAGACACTTGTGGGGGTGATTCTGGGGGTCCACTTGTCTGTAATGGTGTGCTTCAAG
GTATCACATCATGGGGCCCTGAGCCATGTGCCCTGCCTGAAAAGCCTGCTGTGTACACCAAGGTGGTGCATTACCGGAAGTGGATCAAGG
ACACCATCGCAGCCAACCCCTGAGTGCCCCTGTCCCACCCCTACCTCTAGTAAATTTAAGTCCACCTCACGTTCTGGCATCACTTGGCCT
TTCTGGATGCTGGACACCTGAAGCTTGGAACTCACCTGGCCGAAGCTCGAGCCTCCTGAGTCCTACTGACCTGTGCTTTCTGGTGTGGAG
TCCAGGGCTGCTAGGAAAAGGAATGGGCAGACACAGGTGTATGCCAATGTTTCTGAAATGGGTATAATTTCGTCCTCTCCTTCGGAACAC
TGGCTGTCTCTGAAGACTTCTCGCTCAGTTTCAGTGAGGACACACACAAAGACGTGGGTGACCATGTTGTTTGTGGGGTGCAGAGATGGG
AGGGGTGGGGCCCACCCTGGAAGAGTGGACAGTGACACAAGGTGGACACTCTCTACAGATCACTGAGGATAAGCTGGAGCCACAATGCAT
GAGGCACACACACAGCAAGGATGACGCTGTAAACATAGCCCACGCTGTCCTGGGGGCACTGGGAAGCCTAGATAAGGCCGTGAGCAGAAA
GAAGGGGAGGATCCTCCTATGTTGTTGAAGGAGGGACTAGGGGGAGAAACTGAAAGCTGATTAATTACAGGAGGTTTGTTCAGGTCCCCC
AAACCACCGTCAGATTTGATGATTTCCTAGCAGGACTTACAGAAATAAAGAGCTATCATGCTGTGGTTTATTATGGTTTGTTACATTGAT
AGGATACATACTGAAATCAGCAAACAAAACAGATGTATAGATTAGAGTGTGGAGAAAACAGAGGAAAACTTGCAGTTACGAAGACTGGCA
ACTTGGCTTTACTAAGTTTTCAGACTGGCAGGAAGTCAAACCTATTAGGCTGAGGACCTTGTGGAGTGTAGCTGATCCAGCTGATAGAGG
AACTAGCCAGGTGGGGGCCTTTCCCTTTGGATGGGGGGCATATCTGACAGTTATTCTCTCCAAGTGGAGACTTACGGACAGCATATAATT
CTCCCTGCAAGGATGTATGATAATATGTACAAAGTAATTCCAACTGAGGAAGCTCACCTGATCCTTAGTGTCCAGGGTTTTTACTGGGGG
TCTGTAGGACGAGTATGGAGTACTTGAATAATTGACCTGAAGTCCTCAGACCTGAGGTTCCCTAGAGTTCAAACAGATACAGCATGGTCC
AGAGTCCCAGATGTACAAAAACAGGGATTCATCACAAATCCCATCTTTAGCATGAAGGGTCTGGCATGGCCCAAGGCCCCAAGTATATCA
AGGCACTTGGGCAGAACATGCCAAGGAATCAAATGTCATCTCCCAGGAGTTATTCAAGGGTGAGCCCTTTACTTGGGATGTACAGGCTTT
GAGCAGTGCAGGGCTGCTGAGTCAACCTTTTATTGTACAGGGGATGAGGGAAAGGGAGAGGATGAGGAAGCCCCCCTGGGGATTTGGTTT
GGTCTTGTGATCAGGTGGTCTATGGGGCTATCCCTACAAAGAAGAATCCAGAAATAGGGGCACATTGAGGAATGATACTGAGCCCAAAGA
GCATTCAATCATTGTTTTATTTGCCTTCTTTTCACACCATTGGTGAGGGAGGGATTACCACCCTGGGGTTATGAAGATGGTTGAACACCC
CACACATAGCACCGGAGATATGAGATCAACAGTTTCTTAGCCATAGAGATTCACAGCCCAGAGCAGGAGGACGCTGCACACCATGCAGGA
TGACATGGGGGATGCGCTCGGGATTGGTGTGAAGAAGCAAGGACTGTTAGAGGCAGGCTTTATAGTAACAAGACGGTGGGGCAAACTCTG
ATTTCCGTGGGGGAATGTCATGGTCTTGCTTTACTAAGTTTTGAGACTGGCAGGTAGTGAAACTCATTAGGCTGAGAACCTTGTGGAATG
CAGCTGACCCAGCTGATAGAGGAAGTAGCCAGGTGGGAGCCTTTCCCAGTGGGTGTGGGACATATCTGGCAAGATTTTGTGGCACTCCTG

>In-frame_ENST00000454502_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(amino acids)=336AA_start in transcript=92_stop in transcript=1102
MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQLYGKGYFGKGILSRSRPSFTISDPKLVAKWK
GAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYNMSL
LKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEF

--------------------------------------------------------------
>In-frame_ENST00000402228_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(transcript)=3174nt_BP=426nt
AACGGCGAGCGCGTGGGGCCAAGAAAGGTAAGGGCCCTGGGCGAGGAAAGCGCGGCCCTTTCCGAGTTTGGTGTTTTGCAGCGAAAGGAA
ATCTCGCTCTTCCGAAAGTCCTCCAGGGCGAGAGAGGAAAGGGCCTAGAATACCTCCTCTGAAAAATGGCAGAAGCAGTTTTCCATGCCC
CAAAGAGGAAAAGAAGAGTGTATGAGACTTACGAGTCTCCATTGCCAATCCCTTTTGGTCAGGACCATGGTCCTCTGAAAGAATTCAAGA
TATTCCGTGCTGAAATGATTAACAACAATGTGATTGTGAGGAATGCGGAGGACATTGAGCAGCTCTATGGGAAAGGTTATTTTGGAAAAG
GTATTCTTTCAAGAAGCCGTCCAAGCTTCACAATTTCAGATCCTAAACTGGTTGCTAAATGGAAAGGTGCCGTGCCCCTCATCCAGTCTC
GGATTGTGGGAGGCTGGGAGTGTGAGAAGCATTCCCAACCCTGGCAGGTGGCTGTGTACAGTCATGGATGGGCACACTGTGGGGGTGTCC
TGGTGCACCCCCAGTGGGTGCTCACAGCTGCCCATTGCCTAAAGAAGAATAGCCAGGTCTGGCTGGGTCGGCACAACCTGTTTGAGCCTG
AAGACACAGGCCAGAGGGTCCCTGTCAGCCACAGCTTCCCACACCCGCTCTACAATATGAGCCTTCTGAAGCATCAAAGCCTTAGACCAG
ATGAAGACTCCAGCCATGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCAAGATCACAGATGTTGTGAAGGTCCTGGGCCTGCCCACCC
AGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATCGAACCAGAGGAGTTCTTGCGCCCCAGGAGTCTTCAGTGTG
TGAGCCTCCATCTCCTGTCCAATGACATGTGTGCTAGAGCTTACTCTGAGAAGGTGACAGAGTTCATGTTGTGTGCTGGGCTCTGGACAG
GTGGTAAAGACACTTGTGGGGGTGATTCTGGGGGTCCACTTGTCTGTAATGGTGTGCTTCAAGGTATCACATCATGGGGCCCTGAGCCAT
GTGCCCTGCCTGAAAAGCCTGCTGTGTACACCAAGGTGGTGCATTACCGGAAGTGGATCAAGGACACCATCGCAGCCAACCCCTGAGTGC
CCCTGTCCCACCCCTACCTCTAGTAAATTTAAGTCCACCTCACGTTCTGGCATCACTTGGCCTTTCTGGATGCTGGACACCTGAAGCTTG
GAACTCACCTGGCCGAAGCTCGAGCCTCCTGAGTCCTACTGACCTGTGCTTTCTGGTGTGGAGTCCAGGGCTGCTAGGAAAAGGAATGGG
CAGACACAGGTGTATGCCAATGTTTCTGAAATGGGTATAATTTCGTCCTCTCCTTCGGAACACTGGCTGTCTCTGAAGACTTCTCGCTCA
GTTTCAGTGAGGACACACACAAAGACGTGGGTGACCATGTTGTTTGTGGGGTGCAGAGATGGGAGGGGTGGGGCCCACCCTGGAAGAGTG
GACAGTGACACAAGGTGGACACTCTCTACAGATCACTGAGGATAAGCTGGAGCCACAATGCATGAGGCACACACACAGCAAGGATGACGC
TGTAAACATAGCCCACGCTGTCCTGGGGGCACTGGGAAGCCTAGATAAGGCCGTGAGCAGAAAGAAGGGGAGGATCCTCCTATGTTGTTG
AAGGAGGGACTAGGGGGAGAAACTGAAAGCTGATTAATTACAGGAGGTTTGTTCAGGTCCCCCAAACCACCGTCAGATTTGATGATTTCC
TAGCAGGACTTACAGAAATAAAGAGCTATCATGCTGTGGTTTATTATGGTTTGTTACATTGATAGGATACATACTGAAATCAGCAAACAA
AACAGATGTATAGATTAGAGTGTGGAGAAAACAGAGGAAAACTTGCAGTTACGAAGACTGGCAACTTGGCTTTACTAAGTTTTCAGACTG
GCAGGAAGTCAAACCTATTAGGCTGAGGACCTTGTGGAGTGTAGCTGATCCAGCTGATAGAGGAACTAGCCAGGTGGGGGCCTTTCCCTT
TGGATGGGGGGCATATCTGACAGTTATTCTCTCCAAGTGGAGACTTACGGACAGCATATAATTCTCCCTGCAAGGATGTATGATAATATG
TACAAAGTAATTCCAACTGAGGAAGCTCACCTGATCCTTAGTGTCCAGGGTTTTTACTGGGGGTCTGTAGGACGAGTATGGAGTACTTGA
ATAATTGACCTGAAGTCCTCAGACCTGAGGTTCCCTAGAGTTCAAACAGATACAGCATGGTCCAGAGTCCCAGATGTACAAAAACAGGGA
TTCATCACAAATCCCATCTTTAGCATGAAGGGTCTGGCATGGCCCAAGGCCCCAAGTATATCAAGGCACTTGGGCAGAACATGCCAAGGA
ATCAAATGTCATCTCCCAGGAGTTATTCAAGGGTGAGCCCTTTACTTGGGATGTACAGGCTTTGAGCAGTGCAGGGCTGCTGAGTCAACC
TTTTATTGTACAGGGGATGAGGGAAAGGGAGAGGATGAGGAAGCCCCCCTGGGGATTTGGTTTGGTCTTGTGATCAGGTGGTCTATGGGG
CTATCCCTACAAAGAAGAATCCAGAAATAGGGGCACATTGAGGAATGATACTGAGCCCAAAGAGCATTCAATCATTGTTTTATTTGCCTT
CTTTTCACACCATTGGTGAGGGAGGGATTACCACCCTGGGGTTATGAAGATGGTTGAACACCCCACACATAGCACCGGAGATATGAGATC
AACAGTTTCTTAGCCATAGAGATTCACAGCCCAGAGCAGGAGGACGCTGCACACCATGCAGGATGACATGGGGGATGCGCTCGGGATTGG
TGTGAAGAAGCAAGGACTGTTAGAGGCAGGCTTTATAGTAACAAGACGGTGGGGCAAACTCTGATTTCCGTGGGGGAATGTCATGGTCTT
GCTTTACTAAGTTTTGAGACTGGCAGGTAGTGAAACTCATTAGGCTGAGAACCTTGTGGAATGCAGCTGACCCAGCTGATAGAGGAAGTA
GCCAGGTGGGAGCCTTTCCCAGTGGGTGTGGGACATATCTGGCAAGATTTTGTGGCACTCCTGGTTACAGATACTGGGGCAGCAAATAAA

>In-frame_ENST00000402228_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(amino acids)=336AA_start in transcript=155_stop in transcript=1165
MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQLYGKGYFGKGILSRSRPSFTISDPKLVAKWK
GAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYNMSL
LKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEF

--------------------------------------------------------------
>In-frame_ENST00000444864_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(transcript)=3406nt_BP=658nt
AAGAAAGGTAAGGGCCCTGGGCGAGGAAAGCGCGGCCCTTTCCGAGTTTGGTGTTTTGCAGCGAAAGGAAATCTCGCTCTTCCGAAAGTC
CTCCAGGGCGAGAGAGGAAAGGGCCTAGGTACTGTGCTGGGGTCGCACAGCCGGCCGAGACAGTGCCGGGACGGGGAGCCAGGCTTCCGA
GTGCGCCCGGTCACTGACTCCTCCGCGCTTTCCTCGTGCGCCTGCAGCCCTTGGTTCTTGGAAACGCCGGCGCCTTGTTCAGGGCTGGTG
GGGCTGGGGCGCAAGGTGCAGCTGACAATGCCCGAGAGGAGCCGCAGCCTCTGGTGGAGTTCGGTCGGGTGTGGGGGTAGTCAAGGAAAG
AAGCAAAGGGAATACCTCCTCTGAAAAATGGCAGAAGCAGTTTTCCATGCCCCAAAGAGGAAAAGAAGAGTGTATGAGACTTACGAGTCT
CCATTGCCAATCCCTTTTGGTCAGGACCATGGTCCTCTGAAAGAATTCAAGATATTCCGTGCTGAAATGATTAACAACAATGTGATTGTG
AGGAATGCGGAGGACATTGAGCAGCTCTATGGGAAAGGTTATTTTGGAAAAGGTATTCTTTCAAGAAGCCGTCCAAGCTTCACAATTTCA
GATCCTAAACTGGTTGCTAAATGGAAAGGTGCCGTGCCCCTCATCCAGTCTCGGATTGTGGGAGGCTGGGAGTGTGAGAAGCATTCCCAA
CCCTGGCAGGTGGCTGTGTACAGTCATGGATGGGCACACTGTGGGGGTGTCCTGGTGCACCCCCAGTGGGTGCTCACAGCTGCCCATTGC
CTAAAGAAGAATAGCCAGGTCTGGCTGGGTCGGCACAACCTGTTTGAGCCTGAAGACACAGGCCAGAGGGTCCCTGTCAGCCACAGCTTC
CCACACCCGCTCTACAATATGAGCCTTCTGAAGCATCAAAGCCTTAGACCAGATGAAGACTCCAGCCATGACCTCATGCTGCTCCGCCTG
TCAGAGCCTGCCAAGATCACAGATGTTGTGAAGGTCCTGGGCCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGC
TGGGGCAGCATCGAACCAGAGGAGTTCTTGCGCCCCAGGAGTCTTCAGTGTGTGAGCCTCCATCTCCTGTCCAATGACATGTGTGCTAGA
GCTTACTCTGAGAAGGTGACAGAGTTCATGTTGTGTGCTGGGCTCTGGACAGGTGGTAAAGACACTTGTGGGGGTGATTCTGGGGGTCCA
CTTGTCTGTAATGGTGTGCTTCAAGGTATCACATCATGGGGCCCTGAGCCATGTGCCCTGCCTGAAAAGCCTGCTGTGTACACCAAGGTG
GTGCATTACCGGAAGTGGATCAAGGACACCATCGCAGCCAACCCCTGAGTGCCCCTGTCCCACCCCTACCTCTAGTAAATTTAAGTCCAC
CTCACGTTCTGGCATCACTTGGCCTTTCTGGATGCTGGACACCTGAAGCTTGGAACTCACCTGGCCGAAGCTCGAGCCTCCTGAGTCCTA
CTGACCTGTGCTTTCTGGTGTGGAGTCCAGGGCTGCTAGGAAAAGGAATGGGCAGACACAGGTGTATGCCAATGTTTCTGAAATGGGTAT
AATTTCGTCCTCTCCTTCGGAACACTGGCTGTCTCTGAAGACTTCTCGCTCAGTTTCAGTGAGGACACACACAAAGACGTGGGTGACCAT
GTTGTTTGTGGGGTGCAGAGATGGGAGGGGTGGGGCCCACCCTGGAAGAGTGGACAGTGACACAAGGTGGACACTCTCTACAGATCACTG
AGGATAAGCTGGAGCCACAATGCATGAGGCACACACACAGCAAGGATGACGCTGTAAACATAGCCCACGCTGTCCTGGGGGCACTGGGAA
GCCTAGATAAGGCCGTGAGCAGAAAGAAGGGGAGGATCCTCCTATGTTGTTGAAGGAGGGACTAGGGGGAGAAACTGAAAGCTGATTAAT
TACAGGAGGTTTGTTCAGGTCCCCCAAACCACCGTCAGATTTGATGATTTCCTAGCAGGACTTACAGAAATAAAGAGCTATCATGCTGTG
GTTTATTATGGTTTGTTACATTGATAGGATACATACTGAAATCAGCAAACAAAACAGATGTATAGATTAGAGTGTGGAGAAAACAGAGGA
AAACTTGCAGTTACGAAGACTGGCAACTTGGCTTTACTAAGTTTTCAGACTGGCAGGAAGTCAAACCTATTAGGCTGAGGACCTTGTGGA
GTGTAGCTGATCCAGCTGATAGAGGAACTAGCCAGGTGGGGGCCTTTCCCTTTGGATGGGGGGCATATCTGACAGTTATTCTCTCCAAGT
GGAGACTTACGGACAGCATATAATTCTCCCTGCAAGGATGTATGATAATATGTACAAAGTAATTCCAACTGAGGAAGCTCACCTGATCCT
TAGTGTCCAGGGTTTTTACTGGGGGTCTGTAGGACGAGTATGGAGTACTTGAATAATTGACCTGAAGTCCTCAGACCTGAGGTTCCCTAG
AGTTCAAACAGATACAGCATGGTCCAGAGTCCCAGATGTACAAAAACAGGGATTCATCACAAATCCCATCTTTAGCATGAAGGGTCTGGC
ATGGCCCAAGGCCCCAAGTATATCAAGGCACTTGGGCAGAACATGCCAAGGAATCAAATGTCATCTCCCAGGAGTTATTCAAGGGTGAGC
CCTTTACTTGGGATGTACAGGCTTTGAGCAGTGCAGGGCTGCTGAGTCAACCTTTTATTGTACAGGGGATGAGGGAAAGGGAGAGGATGA
GGAAGCCCCCCTGGGGATTTGGTTTGGTCTTGTGATCAGGTGGTCTATGGGGCTATCCCTACAAAGAAGAATCCAGAAATAGGGGCACAT
TGAGGAATGATACTGAGCCCAAAGAGCATTCAATCATTGTTTTATTTGCCTTCTTTTCACACCATTGGTGAGGGAGGGATTACCACCCTG
GGGTTATGAAGATGGTTGAACACCCCACACATAGCACCGGAGATATGAGATCAACAGTTTCTTAGCCATAGAGATTCACAGCCCAGAGCA
GGAGGACGCTGCACACCATGCAGGATGACATGGGGGATGCGCTCGGGATTGGTGTGAAGAAGCAAGGACTGTTAGAGGCAGGCTTTATAG
TAACAAGACGGTGGGGCAAACTCTGATTTCCGTGGGGGAATGTCATGGTCTTGCTTTACTAAGTTTTGAGACTGGCAGGTAGTGAAACTC
ATTAGGCTGAGAACCTTGTGGAATGCAGCTGACCCAGCTGATAGAGGAAGTAGCCAGGTGGGAGCCTTTCCCAGTGGGTGTGGGACATAT

>In-frame_ENST00000444864_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(amino acids)=336AA_start in transcript=387_stop in transcript=1397
MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQLYGKGYFGKGILSRSRPSFTISDPKLVAKWK
GAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYNMSL
LKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEF

--------------------------------------------------------------
>In-frame_ENST00000284995_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(transcript)=3406nt_BP=658nt
AAGAAAGGTAAGGGCCCTGGGCGAGGAAAGCGCGGCCCTTTCCGAGTTTGGTGTTTTGCAGCGAAAGGAAATCTCGCTCTTCCGAAAGTC
CTCCAGGGCGAGAGAGGAAAGGGCCTAGGTACTGTGCTGGGGTCGCACAGCCGGCCGAGACAGTGCCGGGACGGGGAGCCAGGCTTCCGA
GTGCGCCCGGTCACTGACTCCTCCGCGCTTTCCTCGTGCGCCTGCAGCCCTTGGTTCTTGGAAACGCCGGCGCCTTGTTCAGGGCTGGTG
GGGCTGGGGCGCAAGGTGCAGCTGACAATGCCCGAGAGGAGCCGCAGCCTCTGGTGGAGTTCGGTCGGGTGTGGGGGTAGTCAAGGAAAG
AAGCAAAGGGAATACCTCCTCTGAAAAATGGCAGAAGCAGTTTTCCATGCCCCAAAGAGGAAAAGAAGAGTGTATGAGACTTACGAGTCT
CCATTGCCAATCCCTTTTGGTCAGGACCATGGTCCTCTGAAAGAATTCAAGATATTCCGTGCTGAAATGATTAACAACAATGTGATTGTG
AGGAATGCGGAGGACATTGAGCAGCTCTATGGGAAAGGTTATTTTGGAAAAGGTATTCTTTCAAGAAGCCGTCCAAGCTTCACAATTTCA
GATCCTAAACTGGTTGCTAAATGGAAAGGTGCCGTGCCCCTCATCCAGTCTCGGATTGTGGGAGGCTGGGAGTGTGAGAAGCATTCCCAA
CCCTGGCAGGTGGCTGTGTACAGTCATGGATGGGCACACTGTGGGGGTGTCCTGGTGCACCCCCAGTGGGTGCTCACAGCTGCCCATTGC
CTAAAGAAGAATAGCCAGGTCTGGCTGGGTCGGCACAACCTGTTTGAGCCTGAAGACACAGGCCAGAGGGTCCCTGTCAGCCACAGCTTC
CCACACCCGCTCTACAATATGAGCCTTCTGAAGCATCAAAGCCTTAGACCAGATGAAGACTCCAGCCATGACCTCATGCTGCTCCGCCTG
TCAGAGCCTGCCAAGATCACAGATGTTGTGAAGGTCCTGGGCCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGC
TGGGGCAGCATCGAACCAGAGGAGTTCTTGCGCCCCAGGAGTCTTCAGTGTGTGAGCCTCCATCTCCTGTCCAATGACATGTGTGCTAGA
GCTTACTCTGAGAAGGTGACAGAGTTCATGTTGTGTGCTGGGCTCTGGACAGGTGGTAAAGACACTTGTGGGGGTGATTCTGGGGGTCCA
CTTGTCTGTAATGGTGTGCTTCAAGGTATCACATCATGGGGCCCTGAGCCATGTGCCCTGCCTGAAAAGCCTGCTGTGTACACCAAGGTG
GTGCATTACCGGAAGTGGATCAAGGACACCATCGCAGCCAACCCCTGAGTGCCCCTGTCCCACCCCTACCTCTAGTAAATTTAAGTCCAC
CTCACGTTCTGGCATCACTTGGCCTTTCTGGATGCTGGACACCTGAAGCTTGGAACTCACCTGGCCGAAGCTCGAGCCTCCTGAGTCCTA
CTGACCTGTGCTTTCTGGTGTGGAGTCCAGGGCTGCTAGGAAAAGGAATGGGCAGACACAGGTGTATGCCAATGTTTCTGAAATGGGTAT
AATTTCGTCCTCTCCTTCGGAACACTGGCTGTCTCTGAAGACTTCTCGCTCAGTTTCAGTGAGGACACACACAAAGACGTGGGTGACCAT
GTTGTTTGTGGGGTGCAGAGATGGGAGGGGTGGGGCCCACCCTGGAAGAGTGGACAGTGACACAAGGTGGACACTCTCTACAGATCACTG
AGGATAAGCTGGAGCCACAATGCATGAGGCACACACACAGCAAGGATGACGCTGTAAACATAGCCCACGCTGTCCTGGGGGCACTGGGAA
GCCTAGATAAGGCCGTGAGCAGAAAGAAGGGGAGGATCCTCCTATGTTGTTGAAGGAGGGACTAGGGGGAGAAACTGAAAGCTGATTAAT
TACAGGAGGTTTGTTCAGGTCCCCCAAACCACCGTCAGATTTGATGATTTCCTAGCAGGACTTACAGAAATAAAGAGCTATCATGCTGTG
GTTTATTATGGTTTGTTACATTGATAGGATACATACTGAAATCAGCAAACAAAACAGATGTATAGATTAGAGTGTGGAGAAAACAGAGGA
AAACTTGCAGTTACGAAGACTGGCAACTTGGCTTTACTAAGTTTTCAGACTGGCAGGAAGTCAAACCTATTAGGCTGAGGACCTTGTGGA
GTGTAGCTGATCCAGCTGATAGAGGAACTAGCCAGGTGGGGGCCTTTCCCTTTGGATGGGGGGCATATCTGACAGTTATTCTCTCCAAGT
GGAGACTTACGGACAGCATATAATTCTCCCTGCAAGGATGTATGATAATATGTACAAAGTAATTCCAACTGAGGAAGCTCACCTGATCCT
TAGTGTCCAGGGTTTTTACTGGGGGTCTGTAGGACGAGTATGGAGTACTTGAATAATTGACCTGAAGTCCTCAGACCTGAGGTTCCCTAG
AGTTCAAACAGATACAGCATGGTCCAGAGTCCCAGATGTACAAAAACAGGGATTCATCACAAATCCCATCTTTAGCATGAAGGGTCTGGC
ATGGCCCAAGGCCCCAAGTATATCAAGGCACTTGGGCAGAACATGCCAAGGAATCAAATGTCATCTCCCAGGAGTTATTCAAGGGTGAGC
CCTTTACTTGGGATGTACAGGCTTTGAGCAGTGCAGGGCTGCTGAGTCAACCTTTTATTGTACAGGGGATGAGGGAAAGGGAGAGGATGA
GGAAGCCCCCCTGGGGATTTGGTTTGGTCTTGTGATCAGGTGGTCTATGGGGCTATCCCTACAAAGAAGAATCCAGAAATAGGGGCACAT
TGAGGAATGATACTGAGCCCAAAGAGCATTCAATCATTGTTTTATTTGCCTTCTTTTCACACCATTGGTGAGGGAGGGATTACCACCCTG
GGGTTATGAAGATGGTTGAACACCCCACACATAGCACCGGAGATATGAGATCAACAGTTTCTTAGCCATAGAGATTCACAGCCCAGAGCA
GGAGGACGCTGCACACCATGCAGGATGACATGGGGGATGCGCTCGGGATTGGTGTGAAGAAGCAAGGACTGTTAGAGGCAGGCTTTATAG
TAACAAGACGGTGGGGCAAACTCTGATTTCCGTGGGGGAATGTCATGGTCTTGCTTTACTAAGTTTTGAGACTGGCAGGTAGTGAAACTC
ATTAGGCTGAGAACCTTGTGGAATGCAGCTGACCCAGCTGATAGAGGAAGTAGCCAGGTGGGAGCCTTTCCCAGTGGGTGTGGGACATAT

>In-frame_ENST00000284995_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(amino acids)=336AA_start in transcript=387_stop in transcript=1397
MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQLYGKGYFGKGILSRSRPSFTISDPKLVAKWK
GAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYNMSL
LKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEF

--------------------------------------------------------------
>In-frame_ENST00000415684_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(transcript)=3040nt_BP=292nt
AAAGAATACCTCCTCTGAAAAATGGCAGAAGCAGTTTTCCATGCCCCAAAGAGGAAAAGAAGAGTGTATGAGACTTACGAGTCTCCATTG
CCAATCCCTTTTGGTCAGGACCATGGTCCTCTGAAAGAATTCAAGATATTCCGTGCTGAAATGATTAACAACAATGTGATTGTGAGGAAT
GCGGAGGACATTGAGCAGCTCTATGGGAAAGGTTATTTTGGAAAAGGTATTCTTTCAAGAAGCCGTCCAAGCTTCACAATTTCAGATCCT
AAACTGGTTGCTAAATGGAAAGGTGCCGTGCCCCTCATCCAGTCTCGGATTGTGGGAGGCTGGGAGTGTGAGAAGCATTCCCAACCCTGG
CAGGTGGCTGTGTACAGTCATGGATGGGCACACTGTGGGGGTGTCCTGGTGCACCCCCAGTGGGTGCTCACAGCTGCCCATTGCCTAAAG
AAGAATAGCCAGGTCTGGCTGGGTCGGCACAACCTGTTTGAGCCTGAAGACACAGGCCAGAGGGTCCCTGTCAGCCACAGCTTCCCACAC
CCGCTCTACAATATGAGCCTTCTGAAGCATCAAAGCCTTAGACCAGATGAAGACTCCAGCCATGACCTCATGCTGCTCCGCCTGTCAGAG
CCTGCCAAGATCACAGATGTTGTGAAGGTCCTGGGCCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGC
AGCATCGAACCAGAGGAGTTCTTGCGCCCCAGGAGTCTTCAGTGTGTGAGCCTCCATCTCCTGTCCAATGACATGTGTGCTAGAGCTTAC
TCTGAGAAGGTGACAGAGTTCATGTTGTGTGCTGGGCTCTGGACAGGTGGTAAAGACACTTGTGGGGGTGATTCTGGGGGTCCACTTGTC
TGTAATGGTGTGCTTCAAGGTATCACATCATGGGGCCCTGAGCCATGTGCCCTGCCTGAAAAGCCTGCTGTGTACACCAAGGTGGTGCAT
TACCGGAAGTGGATCAAGGACACCATCGCAGCCAACCCCTGAGTGCCCCTGTCCCACCCCTACCTCTAGTAAATTTAAGTCCACCTCACG
TTCTGGCATCACTTGGCCTTTCTGGATGCTGGACACCTGAAGCTTGGAACTCACCTGGCCGAAGCTCGAGCCTCCTGAGTCCTACTGACC
TGTGCTTTCTGGTGTGGAGTCCAGGGCTGCTAGGAAAAGGAATGGGCAGACACAGGTGTATGCCAATGTTTCTGAAATGGGTATAATTTC
GTCCTCTCCTTCGGAACACTGGCTGTCTCTGAAGACTTCTCGCTCAGTTTCAGTGAGGACACACACAAAGACGTGGGTGACCATGTTGTT
TGTGGGGTGCAGAGATGGGAGGGGTGGGGCCCACCCTGGAAGAGTGGACAGTGACACAAGGTGGACACTCTCTACAGATCACTGAGGATA
AGCTGGAGCCACAATGCATGAGGCACACACACAGCAAGGATGACGCTGTAAACATAGCCCACGCTGTCCTGGGGGCACTGGGAAGCCTAG
ATAAGGCCGTGAGCAGAAAGAAGGGGAGGATCCTCCTATGTTGTTGAAGGAGGGACTAGGGGGAGAAACTGAAAGCTGATTAATTACAGG
AGGTTTGTTCAGGTCCCCCAAACCACCGTCAGATTTGATGATTTCCTAGCAGGACTTACAGAAATAAAGAGCTATCATGCTGTGGTTTAT
TATGGTTTGTTACATTGATAGGATACATACTGAAATCAGCAAACAAAACAGATGTATAGATTAGAGTGTGGAGAAAACAGAGGAAAACTT
GCAGTTACGAAGACTGGCAACTTGGCTTTACTAAGTTTTCAGACTGGCAGGAAGTCAAACCTATTAGGCTGAGGACCTTGTGGAGTGTAG
CTGATCCAGCTGATAGAGGAACTAGCCAGGTGGGGGCCTTTCCCTTTGGATGGGGGGCATATCTGACAGTTATTCTCTCCAAGTGGAGAC
TTACGGACAGCATATAATTCTCCCTGCAAGGATGTATGATAATATGTACAAAGTAATTCCAACTGAGGAAGCTCACCTGATCCTTAGTGT
CCAGGGTTTTTACTGGGGGTCTGTAGGACGAGTATGGAGTACTTGAATAATTGACCTGAAGTCCTCAGACCTGAGGTTCCCTAGAGTTCA
AACAGATACAGCATGGTCCAGAGTCCCAGATGTACAAAAACAGGGATTCATCACAAATCCCATCTTTAGCATGAAGGGTCTGGCATGGCC
CAAGGCCCCAAGTATATCAAGGCACTTGGGCAGAACATGCCAAGGAATCAAATGTCATCTCCCAGGAGTTATTCAAGGGTGAGCCCTTTA
CTTGGGATGTACAGGCTTTGAGCAGTGCAGGGCTGCTGAGTCAACCTTTTATTGTACAGGGGATGAGGGAAAGGGAGAGGATGAGGAAGC
CCCCCTGGGGATTTGGTTTGGTCTTGTGATCAGGTGGTCTATGGGGCTATCCCTACAAAGAAGAATCCAGAAATAGGGGCACATTGAGGA
ATGATACTGAGCCCAAAGAGCATTCAATCATTGTTTTATTTGCCTTCTTTTCACACCATTGGTGAGGGAGGGATTACCACCCTGGGGTTA
TGAAGATGGTTGAACACCCCACACATAGCACCGGAGATATGAGATCAACAGTTTCTTAGCCATAGAGATTCACAGCCCAGAGCAGGAGGA
CGCTGCACACCATGCAGGATGACATGGGGGATGCGCTCGGGATTGGTGTGAAGAAGCAAGGACTGTTAGAGGCAGGCTTTATAGTAACAA
GACGGTGGGGCAAACTCTGATTTCCGTGGGGGAATGTCATGGTCTTGCTTTACTAAGTTTTGAGACTGGCAGGTAGTGAAACTCATTAGG
CTGAGAACCTTGTGGAATGCAGCTGACCCAGCTGATAGAGGAAGTAGCCAGGTGGGAGCCTTTCCCAGTGGGTGTGGGACATATCTGGCA

>In-frame_ENST00000415684_ENST00000325321_TCGA-G9-6378_TSEN2_chr3_12533716_+_KLK2_chr19_51377977_length(amino acids)=336AA_start in transcript=21_stop in transcript=1031
MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQLYGKGYFGKGILSRSRPSFTISDPKLVAKWK
GAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEPEDTGQRVPVSHSFPHPLYNMSL
LKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TSEN2-KLK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TSEN2-KLK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TSEN2-KLK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TSEN2	C2676466	Pontocerebellar Hypoplasia Type 2B	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	TSEN2	C0011168	Deglutition Disorders	1	CTD_human
Hgene	TSEN2	C0018975	Hemeralopia	1	CTD_human
Hgene	TSEN2	C0020796	Profound Mental Retardation	1	CTD_human
Hgene	TSEN2	C0025363	Mental Retardation, Psychosocial	1	CTD_human
Hgene	TSEN2	C0025958	Microcephaly	1	CTD_human
Hgene	TSEN2	C0026650	Movement Disorders	1	CTD_human
Hgene	TSEN2	C0042790	Vision Disorders	1	CTD_human
Hgene	TSEN2	C0043094	Weight Gain	1	CTD_human
Hgene	TSEN2	C0233769	Micropsia	1	CTD_human
Hgene	TSEN2	C0233771	Macropsia	1	CTD_human
Hgene	TSEN2	C0266468	Congenital pontocerebellar hypoplasia	1	GENOMICS_ENGLAND
Hgene	TSEN2	C0266487	Etat Marbre	1	CTD_human
Hgene	TSEN2	C0267071	Oropharyngeal Dysphagia	1	CTD_human
Hgene	TSEN2	C0267072	Esophageal Dysphagia	1	CTD_human
Hgene	TSEN2	C0271185	Metamorphopsia	1	CTD_human
Hgene	TSEN2	C0917816	Mental deficiency	1	CTD_human
Hgene	TSEN2	C1956147	Microlissencephaly	1	CTD_human
Hgene	TSEN2	C2932714	Pontocerebellar Hypoplasia Type 2	1	ORPHANET
Hgene	TSEN2	C3489704	Vision Disability	1	CTD_human
Hgene	TSEN2	C3665347	Visual Impairment	1	CTD_human
Hgene	TSEN2	C3714756	Intellectual Disability	1	CTD_human
Hgene	TSEN2	C3853041	Severe Congenital Microcephaly	1	CTD_human
Tgene	KLK2	C0033578	Prostatic Neoplasms	2	CTD_human
Tgene	KLK2	C0376358	Malignant neoplasm of prostate	2	CTD_human