FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TSFM-DOCK2 (FusionGDB2 ID:93894)

Fusion Gene Summary for TSFM-DOCK2

check button Fusion gene summary
Fusion gene informationFusion gene name: TSFM-DOCK2
Fusion gene ID: 93894
HgeneTgene
Gene symbol

TSFM

DOCK2

Gene ID

10102

1794

Gene nameTs translation elongation factor, mitochondrialdedicator of cytokinesis 2
SynonymsEFTS|EFTSMTIMD40
Cytomap

12q14.1

5q35.1

Type of geneprotein-codingprotein-coding
Descriptionelongation factor Ts, mitochondrialEF-TsEF-TsMtmitochondrial elongation factor Tsdedicator of cytokinesis protein 2dedicator of cyto-kinesis 2
Modification date2020031320200313
UniProtAcc.

Q92608

Ensembl transtripts involved in fusion geneENST00000543727, ENST00000550559, 
ENST00000548851, ENST00000454289, 
ENST00000540550, ENST00000323833, 
ENST00000350762, ENST00000497617, 
ENST00000256935, ENST00000540750, 
ENST00000520908, ENST00000523351, 
Fusion gene scores* DoF score26 X 8 X 7=145613 X 12 X 8=1248
# samples 3015
** MAII scorelog2(30/1456*10)=-2.27897594970282
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1248*10)=-3.05658352836637
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSFM [Title/Abstract] AND DOCK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTSFM(58186856)-DOCK2(169174400), # samples:1
TSFM(58186856)-DOCK2(169174399), # samples:1
Anticipated loss of major functional domain due to fusion event.TSFM-DOCK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TSFM-DOCK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTSFM

GO:0070129

regulation of mitochondrial translation

27677415


check buttonFusion gene breakpoints across TSFM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DOCK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1KZ-01ATSFMchr12

58186856

+DOCK2chr5

169174400

+
ChimerDB4SARCTCGA-DX-A1KZTSFMchr12

58186856

+DOCK2chr5

169174399

+


Top

Fusion Gene ORF analysis for TSFM-DOCK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000543727ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-5UTRENST00000543727ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-5UTRENST00000543727ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-intronENST00000543727ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174400

+
Frame-shiftENST00000550559ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-5UTRENST00000550559ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-5UTRENST00000550559ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-intronENST00000550559ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174400

+
Frame-shiftENST00000548851ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-5UTRENST00000548851ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-5UTRENST00000548851ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-intronENST00000548851ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174400

+
Frame-shiftENST00000454289ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-5UTRENST00000454289ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-5UTRENST00000454289ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-intronENST00000454289ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174400

+
intron-3CDSENST00000540550ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174400

+
intron-5UTRENST00000540550ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174400

+
intron-5UTRENST00000540550ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174400

+
intron-intronENST00000540550ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174400

+
Frame-shiftENST00000323833ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-5UTRENST00000323833ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-5UTRENST00000323833ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-intronENST00000323833ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174400

+
Frame-shiftENST00000350762ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-5UTRENST00000350762ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-5UTRENST00000350762ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174400

+
5CDS-intronENST00000350762ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174400

+
3UTR-3CDSENST00000497617ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174400

+
3UTR-5UTRENST00000497617ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174400

+
3UTR-5UTRENST00000497617ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174400

+
3UTR-intronENST00000497617ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174400

+
Frame-shiftENST00000543727ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-5UTRENST00000543727ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-5UTRENST00000543727ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-intronENST00000543727ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174399

+
Frame-shiftENST00000550559ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-5UTRENST00000550559ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-5UTRENST00000550559ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-intronENST00000550559ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174399

+
Frame-shiftENST00000548851ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-5UTRENST00000548851ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-5UTRENST00000548851ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-intronENST00000548851ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174399

+
Frame-shiftENST00000454289ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-5UTRENST00000454289ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-5UTRENST00000454289ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-intronENST00000454289ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174399

+
intron-3CDSENST00000540550ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174399

+
intron-5UTRENST00000540550ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174399

+
intron-5UTRENST00000540550ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174399

+
intron-intronENST00000540550ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174399

+
Frame-shiftENST00000323833ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-5UTRENST00000323833ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-5UTRENST00000323833ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-intronENST00000323833ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174399

+
Frame-shiftENST00000350762ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-5UTRENST00000350762ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-5UTRENST00000350762ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174399

+
5CDS-intronENST00000350762ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174399

+
3UTR-3CDSENST00000497617ENST00000256935TSFMchr12

58186856

+DOCK2chr5

169174399

+
3UTR-5UTRENST00000497617ENST00000540750TSFMchr12

58186856

+DOCK2chr5

169174399

+
3UTR-5UTRENST00000497617ENST00000520908TSFMchr12

58186856

+DOCK2chr5

169174399

+
3UTR-intronENST00000497617ENST00000523351TSFMchr12

58186856

+DOCK2chr5

169174399

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for TSFM-DOCK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TSFMchr1258186856+DOCK2chr5169174399+9.35E-080.9999999
TSFMchr1258186856+DOCK2chr5169174399+9.35E-080.9999999
TSFMchr1258186856+DOCK2chr5169174399+9.35E-080.9999999
TSFMchr1258186856+DOCK2chr5169174399+9.35E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TSFM-DOCK2


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DOCK2

Q92608

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for TSFM-DOCK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for TSFM-DOCK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TSFM-DOCK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TSFM-DOCK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTSFMC1864840Combined Oxidative Phosphorylation Deficiency 36CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneTSFMC0036572Seizures1GENOMICS_ENGLAND
TgeneDOCK2C4225328IMMUNODEFICIENCY 402CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneDOCK2C0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneDOCK2C2931456Prostate cancer, familial1CTD_human
TgeneDOCK2C4722327PROSTATE CANCER, HEREDITARY, 11CTD_human