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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TSG101-TSG101 (FusionGDB2 ID:93920)

Fusion Gene Summary for TSG101-TSG101

check button Fusion gene summary
Fusion gene informationFusion gene name: TSG101-TSG101
Fusion gene ID: 93920
HgeneTgene
Gene symbol

TSG101

TSG101

Gene ID

7251

7251

Gene nametumor susceptibility 101tumor susceptibility 101
SynonymsTSG10|VPS23TSG10|VPS23
Cytomap

11p15.1

11p15.1

Type of geneprotein-codingprotein-coding
Descriptiontumor susceptibility gene 101 proteinESCRT-I complex subunit TSG101tumor susceptibility gene 10tumor susceptibility gene 101tumor susceptibility proteintumor susceptibility gene 101 proteinESCRT-I complex subunit TSG101tumor susceptibility gene 10tumor susceptibility gene 101tumor susceptibility protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000536719, ENST00000251968, 
ENST00000357193, ENST00000543087, 
ENST00000536719, ENST00000251968, 
ENST00000357193, ENST00000543087, 
Fusion gene scores* DoF score7 X 15 X 9=9456 X 7 X 2=84
# samples 167
** MAII scorelog2(16/945*10)=-2.56224242422107
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSG101 [Title/Abstract] AND TSG101 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTSG101(18503182)-TSG101(18503239), # samples:1
TSG101(18503239)-TSG101(18503182), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTSG101

GO:0043162

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

15611048

TgeneTSG101

GO:0043162

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

15611048


check buttonFusion gene breakpoints across TSG101 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TSG101 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW019940TSG101chr11

18503182

-TSG101chr11

18503239

+
ChiTaRS5.0N/ABI490973TSG101chr11

18503239

-TSG101chr11

18503182

+


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Fusion Gene ORF analysis for TSG101-TSG101

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000536719ENST00000536719TSG101chr11

18503182

-TSG101chr11

18503239

+
In-frameENST00000536719ENST00000251968TSG101chr11

18503182

-TSG101chr11

18503239

+
In-frameENST00000536719ENST00000357193TSG101chr11

18503182

-TSG101chr11

18503239

+
5CDS-intronENST00000536719ENST00000543087TSG101chr11

18503182

-TSG101chr11

18503239

+
In-frameENST00000251968ENST00000536719TSG101chr11

18503182

-TSG101chr11

18503239

+
In-frameENST00000251968ENST00000251968TSG101chr11

18503182

-TSG101chr11

18503239

+
In-frameENST00000251968ENST00000357193TSG101chr11

18503182

-TSG101chr11

18503239

+
5CDS-intronENST00000251968ENST00000543087TSG101chr11

18503182

-TSG101chr11

18503239

+
In-frameENST00000357193ENST00000536719TSG101chr11

18503182

-TSG101chr11

18503239

+
In-frameENST00000357193ENST00000251968TSG101chr11

18503182

-TSG101chr11

18503239

+
In-frameENST00000357193ENST00000357193TSG101chr11

18503182

-TSG101chr11

18503239

+
5CDS-intronENST00000357193ENST00000543087TSG101chr11

18503182

-TSG101chr11

18503239

+
intron-3CDSENST00000543087ENST00000536719TSG101chr11

18503182

-TSG101chr11

18503239

+
intron-3CDSENST00000543087ENST00000251968TSG101chr11

18503182

-TSG101chr11

18503239

+
intron-3CDSENST00000543087ENST00000357193TSG101chr11

18503182

-TSG101chr11

18503239

+
intron-intronENST00000543087ENST00000543087TSG101chr11

18503182

-TSG101chr11

18503239

+
intron-intronENST00000536719ENST00000536719TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000536719ENST00000251968TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000536719ENST00000357193TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000536719ENST00000543087TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000251968ENST00000536719TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000251968ENST00000251968TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000251968ENST00000357193TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000251968ENST00000543087TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000357193ENST00000536719TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000357193ENST00000251968TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000357193ENST00000357193TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000357193ENST00000543087TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000543087ENST00000536719TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000543087ENST00000251968TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000543087ENST00000357193TSG101chr11

18503239

-TSG101chr11

18503182

+
intron-intronENST00000543087ENST00000543087TSG101chr11

18503239

-TSG101chr11

18503182

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TSG101-TSG101


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TSG101-TSG101


check button Go to

FGviewer for the breakpoints of chr11:18503182-chr11:18503239

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSG101chr11:18503182chr11:18503239ENST00000251968-910235_316361.0391.0Coiled coilOntology_term=ECO:0000255
HgeneTSG101chr11:18503182chr11:18503239ENST00000251968-9102_145361.0391.0DomainUEV
HgeneTSG101chr11:18503182chr11:18503239ENST00000357193-672_145256.0286.0DomainUEV
HgeneTSG101chr11:18503182chr11:18503239ENST00000251968-910320_323361.0391.0MotifNote=PTAP motif
TgeneTSG101chr11:18503182chr11:18503239ENST00000251968010235_3160391.0Coiled coilOntology_term=ECO:0000255
TgeneTSG101chr11:18503182chr11:18503239ENST0000035719307235_3160286.0Coiled coilOntology_term=ECO:0000255
TgeneTSG101chr11:18503182chr11:18503239ENST000002519680102_1450391.0DomainUEV
TgeneTSG101chr11:18503182chr11:18503239ENST00000251968010322_3900391.0DomainSB
TgeneTSG101chr11:18503182chr11:18503239ENST00000357193072_1450286.0DomainUEV
TgeneTSG101chr11:18503182chr11:18503239ENST0000035719307322_3900286.0DomainSB
TgeneTSG101chr11:18503182chr11:18503239ENST00000251968010320_3230391.0MotifNote=PTAP motif
TgeneTSG101chr11:18503182chr11:18503239ENST0000035719307320_3230286.0MotifNote=PTAP motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSG101chr11:18503182chr11:18503239ENST00000357193-67235_316256.0286.0Coiled coilOntology_term=ECO:0000255
HgeneTSG101chr11:18503182chr11:18503239ENST00000251968-910322_390361.0391.0DomainSB
HgeneTSG101chr11:18503182chr11:18503239ENST00000357193-67322_390256.0286.0DomainSB
HgeneTSG101chr11:18503182chr11:18503239ENST00000357193-67320_323256.0286.0MotifNote=PTAP motif


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Fusion Gene Sequence for TSG101-TSG101


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TSG101-TSG101


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TSG101-TSG101


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TSG101-TSG101


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource