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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TSG101-YWHAB (FusionGDB2 ID:93921)

Fusion Gene Summary for TSG101-YWHAB

check button Fusion gene summary
Fusion gene informationFusion gene name: TSG101-YWHAB
Fusion gene ID: 93921
HgeneTgene
Gene symbol

TSG101

YWHAB

Gene ID

7251

7529

Gene nametumor susceptibility 101tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
SynonymsTSG10|VPS23GW128|HEL-S-1|HS1|KCIP-1|YWHAA
Cytomap

11p15.1

20q13.12

Type of geneprotein-codingprotein-coding
Descriptiontumor susceptibility gene 101 proteinESCRT-I complex subunit TSG101tumor susceptibility gene 10tumor susceptibility gene 101tumor susceptibility protein14-3-3 protein beta/alpha14-3-3 alphabrain protein 14-3-3, beta isoformepididymis secretory protein Li 1protein 1054protein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptidetyrosin
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000536719, ENST00000251968, 
ENST00000357193, ENST00000543087, 
ENST00000353703, ENST00000479421, 
ENST00000372839, 
Fusion gene scores* DoF score7 X 15 X 9=94513 X 25 X 12=3900
# samples 1630
** MAII scorelog2(16/945*10)=-2.56224242422107
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/3900*10)=-3.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSG101 [Title/Abstract] AND YWHAB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTSG101(18512110)-YWHAB(43532656), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTSG101

GO:0043162

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

15611048

TgeneYWHAB

GO:0035308

negative regulation of protein dephosphorylation

17255105

TgeneYWHAB

GO:0043085

positive regulation of catalytic activity

17255105

TgeneYWHAB

GO:0051220

cytoplasmic sequestering of protein

10869435


check buttonFusion gene breakpoints across TSG101 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across YWHAB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-8511-01ATSG101chr11

18512525

+YWHABchr20

43530383

+
ChimerDB4CESCTCGA-EK-A3GM-01ATSG101chr11

18512088

-YWHABchr20

43533700

-
ChimerDB4CESCTCGA-EA-A556-01ATSG101chr11

18512110

+YWHABchr20

43532656

+
ChimerDB4UCECTCGA-A5-A2K3-01ATSG101chr11

18512110

+YWHABchr20

43532656

+
ChimerDB4UCECTCGA-AJ-A6NU-01ATSG101chr11

18512110

+YWHABchr20

43532656

+
ChimerDB4PRADTCGA-CH-5761-01ATSG101chr11

18511838

+YWHABchr20

43535053

+
ChimerDB4PRADTCGA-CH-5761-01ATSG101chr11

18512110

+YWHABchr20

43532656

+
ChimerDB4PRADTCGA-CH-5761-01ATSG101chr11

18512525

+YWHABchr20

43530383

+
ChimerDB4HNSCTCGA-CR-7365-01ATSG101chr11

18512110

+YWHABchr20

43532656

+
ChimerDB4HNSCTCGA-CR-7365-01ATSG101chr11

18512223

+YWHABchr20

43530407

+
ChimerDB4HNSCTCGA-CR-5250-01ATSG101chr11

18511838

+YWHABchr20

43535044

+
ChimerDB4KIRCTCGA-CJ-4897-01ATSG101chr11

18512109

+YWHABchr20

43532655

+
ChimerDB4BRCATCGA-AO-A03O-01ATSG101chr11

18512089

-YWHABchr20

43533689

-
ChimerDB4BRCATCGA-A2-A0YD-01ATSG101chr11

18512223

+YWHABchr20

43530407

+
ChiTaRS5.0N/ABQ961579TSG101chr11

18512062

-YWHABchr20

43530206

+


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Fusion Gene ORF analysis for TSG101-YWHAB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000536719ENST00000353703TSG101chr11

18512525

+YWHABchr20

43530383

+
intron-3UTRENST00000536719ENST00000479421TSG101chr11

18512525

+YWHABchr20

43530383

+
intron-3UTRENST00000536719ENST00000372839TSG101chr11

18512525

+YWHABchr20

43530383

+
intron-3CDSENST00000251968ENST00000353703TSG101chr11

18512525

+YWHABchr20

43530383

+
intron-3UTRENST00000251968ENST00000479421TSG101chr11

18512525

+YWHABchr20

43530383

+
intron-3UTRENST00000251968ENST00000372839TSG101chr11

18512525

+YWHABchr20

43530383

+
intron-3CDSENST00000357193ENST00000353703TSG101chr11

18512525

+YWHABchr20

43530383

+
intron-3UTRENST00000357193ENST00000479421TSG101chr11

18512525

+YWHABchr20

43530383

+
intron-3UTRENST00000357193ENST00000372839TSG101chr11

18512525

+YWHABchr20

43530383

+
intron-3CDSENST00000543087ENST00000353703TSG101chr11

18512525

+YWHABchr20

43530383

+
intron-3UTRENST00000543087ENST00000479421TSG101chr11

18512525

+YWHABchr20

43530383

+
intron-3UTRENST00000543087ENST00000372839TSG101chr11

18512525

+YWHABchr20

43530383

+
intron-3CDSENST00000536719ENST00000353703TSG101chr11

18512088

-YWHABchr20

43533700

-
intron-3UTRENST00000536719ENST00000479421TSG101chr11

18512088

-YWHABchr20

43533700

-
intron-3UTRENST00000536719ENST00000372839TSG101chr11

18512088

-YWHABchr20

43533700

-
intron-3CDSENST00000251968ENST00000353703TSG101chr11

18512088

-YWHABchr20

43533700

-
intron-3UTRENST00000251968ENST00000479421TSG101chr11

18512088

-YWHABchr20

43533700

-
intron-3UTRENST00000251968ENST00000372839TSG101chr11

18512088

-YWHABchr20

43533700

-
intron-3CDSENST00000357193ENST00000353703TSG101chr11

18512088

-YWHABchr20

43533700

-
intron-3UTRENST00000357193ENST00000479421TSG101chr11

18512088

-YWHABchr20

43533700

-
intron-3UTRENST00000357193ENST00000372839TSG101chr11

18512088

-YWHABchr20

43533700

-
intron-3CDSENST00000543087ENST00000353703TSG101chr11

18512088

-YWHABchr20

43533700

-
intron-3UTRENST00000543087ENST00000479421TSG101chr11

18512088

-YWHABchr20

43533700

-
intron-3UTRENST00000543087ENST00000372839TSG101chr11

18512088

-YWHABchr20

43533700

-
intron-3CDSENST00000536719ENST00000353703TSG101chr11

18512110

+YWHABchr20

43532656

+
intron-3UTRENST00000536719ENST00000479421TSG101chr11

18512110

+YWHABchr20

43532656

+
intron-3UTRENST00000536719ENST00000372839TSG101chr11

18512110

+YWHABchr20

43532656

+
intron-3CDSENST00000251968ENST00000353703TSG101chr11

18512110

+YWHABchr20

43532656

+
intron-3UTRENST00000251968ENST00000479421TSG101chr11

18512110

+YWHABchr20

43532656

+
intron-3UTRENST00000251968ENST00000372839TSG101chr11

18512110

+YWHABchr20

43532656

+
intron-3CDSENST00000357193ENST00000353703TSG101chr11

18512110

+YWHABchr20

43532656

+
intron-3UTRENST00000357193ENST00000479421TSG101chr11

18512110

+YWHABchr20

43532656

+
intron-3UTRENST00000357193ENST00000372839TSG101chr11

18512110

+YWHABchr20

43532656

+
intron-3CDSENST00000543087ENST00000353703TSG101chr11

18512110

+YWHABchr20

43532656

+
intron-3UTRENST00000543087ENST00000479421TSG101chr11

18512110

+YWHABchr20

43532656

+
intron-3UTRENST00000543087ENST00000372839TSG101chr11

18512110

+YWHABchr20

43532656

+
intron-3CDSENST00000536719ENST00000353703TSG101chr11

18511838

+YWHABchr20

43535053

+
intron-3UTRENST00000536719ENST00000479421TSG101chr11

18511838

+YWHABchr20

43535053

+
intron-3UTRENST00000536719ENST00000372839TSG101chr11

18511838

+YWHABchr20

43535053

+
intron-3CDSENST00000251968ENST00000353703TSG101chr11

18511838

+YWHABchr20

43535053

+
intron-3UTRENST00000251968ENST00000479421TSG101chr11

18511838

+YWHABchr20

43535053

+
intron-3UTRENST00000251968ENST00000372839TSG101chr11

18511838

+YWHABchr20

43535053

+
intron-3CDSENST00000357193ENST00000353703TSG101chr11

18511838

+YWHABchr20

43535053

+
intron-3UTRENST00000357193ENST00000479421TSG101chr11

18511838

+YWHABchr20

43535053

+
intron-3UTRENST00000357193ENST00000372839TSG101chr11

18511838

+YWHABchr20

43535053

+
intron-3CDSENST00000543087ENST00000353703TSG101chr11

18511838

+YWHABchr20

43535053

+
intron-3UTRENST00000543087ENST00000479421TSG101chr11

18511838

+YWHABchr20

43535053

+
intron-3UTRENST00000543087ENST00000372839TSG101chr11

18511838

+YWHABchr20

43535053

+
intron-3CDSENST00000536719ENST00000353703TSG101chr11

18512223

+YWHABchr20

43530407

+
intron-3UTRENST00000536719ENST00000479421TSG101chr11

18512223

+YWHABchr20

43530407

+
intron-3UTRENST00000536719ENST00000372839TSG101chr11

18512223

+YWHABchr20

43530407

+
intron-3CDSENST00000251968ENST00000353703TSG101chr11

18512223

+YWHABchr20

43530407

+
intron-3UTRENST00000251968ENST00000479421TSG101chr11

18512223

+YWHABchr20

43530407

+
intron-3UTRENST00000251968ENST00000372839TSG101chr11

18512223

+YWHABchr20

43530407

+
intron-3CDSENST00000357193ENST00000353703TSG101chr11

18512223

+YWHABchr20

43530407

+
intron-3UTRENST00000357193ENST00000479421TSG101chr11

18512223

+YWHABchr20

43530407

+
intron-3UTRENST00000357193ENST00000372839TSG101chr11

18512223

+YWHABchr20

43530407

+
intron-3CDSENST00000543087ENST00000353703TSG101chr11

18512223

+YWHABchr20

43530407

+
intron-3UTRENST00000543087ENST00000479421TSG101chr11

18512223

+YWHABchr20

43530407

+
intron-3UTRENST00000543087ENST00000372839TSG101chr11

18512223

+YWHABchr20

43530407

+
intron-3CDSENST00000536719ENST00000353703TSG101chr11

18511838

+YWHABchr20

43535044

+
intron-3UTRENST00000536719ENST00000479421TSG101chr11

18511838

+YWHABchr20

43535044

+
intron-3UTRENST00000536719ENST00000372839TSG101chr11

18511838

+YWHABchr20

43535044

+
intron-3CDSENST00000251968ENST00000353703TSG101chr11

18511838

+YWHABchr20

43535044

+
intron-3UTRENST00000251968ENST00000479421TSG101chr11

18511838

+YWHABchr20

43535044

+
intron-3UTRENST00000251968ENST00000372839TSG101chr11

18511838

+YWHABchr20

43535044

+
intron-3CDSENST00000357193ENST00000353703TSG101chr11

18511838

+YWHABchr20

43535044

+
intron-3UTRENST00000357193ENST00000479421TSG101chr11

18511838

+YWHABchr20

43535044

+
intron-3UTRENST00000357193ENST00000372839TSG101chr11

18511838

+YWHABchr20

43535044

+
intron-3CDSENST00000543087ENST00000353703TSG101chr11

18511838

+YWHABchr20

43535044

+
intron-3UTRENST00000543087ENST00000479421TSG101chr11

18511838

+YWHABchr20

43535044

+
intron-3UTRENST00000543087ENST00000372839TSG101chr11

18511838

+YWHABchr20

43535044

+
intron-3CDSENST00000536719ENST00000353703TSG101chr11

18512109

+YWHABchr20

43532655

+
intron-3UTRENST00000536719ENST00000479421TSG101chr11

18512109

+YWHABchr20

43532655

+
intron-3UTRENST00000536719ENST00000372839TSG101chr11

18512109

+YWHABchr20

43532655

+
intron-3CDSENST00000251968ENST00000353703TSG101chr11

18512109

+YWHABchr20

43532655

+
intron-3UTRENST00000251968ENST00000479421TSG101chr11

18512109

+YWHABchr20

43532655

+
intron-3UTRENST00000251968ENST00000372839TSG101chr11

18512109

+YWHABchr20

43532655

+
intron-3CDSENST00000357193ENST00000353703TSG101chr11

18512109

+YWHABchr20

43532655

+
intron-3UTRENST00000357193ENST00000479421TSG101chr11

18512109

+YWHABchr20

43532655

+
intron-3UTRENST00000357193ENST00000372839TSG101chr11

18512109

+YWHABchr20

43532655

+
intron-3CDSENST00000543087ENST00000353703TSG101chr11

18512109

+YWHABchr20

43532655

+
intron-3UTRENST00000543087ENST00000479421TSG101chr11

18512109

+YWHABchr20

43532655

+
intron-3UTRENST00000543087ENST00000372839TSG101chr11

18512109

+YWHABchr20

43532655

+
intron-3CDSENST00000536719ENST00000353703TSG101chr11

18512089

-YWHABchr20

43533689

-
intron-3UTRENST00000536719ENST00000479421TSG101chr11

18512089

-YWHABchr20

43533689

-
intron-3UTRENST00000536719ENST00000372839TSG101chr11

18512089

-YWHABchr20

43533689

-
intron-3CDSENST00000251968ENST00000353703TSG101chr11

18512089

-YWHABchr20

43533689

-
intron-3UTRENST00000251968ENST00000479421TSG101chr11

18512089

-YWHABchr20

43533689

-
intron-3UTRENST00000251968ENST00000372839TSG101chr11

18512089

-YWHABchr20

43533689

-
intron-3CDSENST00000357193ENST00000353703TSG101chr11

18512089

-YWHABchr20

43533689

-
intron-3UTRENST00000357193ENST00000479421TSG101chr11

18512089

-YWHABchr20

43533689

-
intron-3UTRENST00000357193ENST00000372839TSG101chr11

18512089

-YWHABchr20

43533689

-
intron-3CDSENST00000543087ENST00000353703TSG101chr11

18512089

-YWHABchr20

43533689

-
intron-3UTRENST00000543087ENST00000479421TSG101chr11

18512089

-YWHABchr20

43533689

-
intron-3UTRENST00000543087ENST00000372839TSG101chr11

18512089

-YWHABchr20

43533689

-
intron-3CDSENST00000536719ENST00000353703TSG101chr11

18512062

-YWHABchr20

43530206

+
intron-3UTRENST00000536719ENST00000479421TSG101chr11

18512062

-YWHABchr20

43530206

+
intron-3UTRENST00000536719ENST00000372839TSG101chr11

18512062

-YWHABchr20

43530206

+
intron-3CDSENST00000251968ENST00000353703TSG101chr11

18512062

-YWHABchr20

43530206

+
intron-3UTRENST00000251968ENST00000479421TSG101chr11

18512062

-YWHABchr20

43530206

+
intron-3UTRENST00000251968ENST00000372839TSG101chr11

18512062

-YWHABchr20

43530206

+
intron-3CDSENST00000357193ENST00000353703TSG101chr11

18512062

-YWHABchr20

43530206

+
intron-3UTRENST00000357193ENST00000479421TSG101chr11

18512062

-YWHABchr20

43530206

+
intron-3UTRENST00000357193ENST00000372839TSG101chr11

18512062

-YWHABchr20

43530206

+
intron-3CDSENST00000543087ENST00000353703TSG101chr11

18512062

-YWHABchr20

43530206

+
intron-3UTRENST00000543087ENST00000479421TSG101chr11

18512062

-YWHABchr20

43530206

+
intron-3UTRENST00000543087ENST00000372839TSG101chr11

18512062

-YWHABchr20

43530206

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TSG101-YWHAB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TSG101-YWHAB


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TSG101-YWHAB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TSG101-YWHAB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TSG101-YWHAB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TSG101-YWHAB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource