Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BCL11B-HLA-C (FusionGDB2 ID:9399)

Fusion Gene Summary for BCL11B-HLA-C

Fusion gene summary

Fusion gene information	Fusion gene name: BCL11B-HLA-C
	Fusion gene ID: 9399
		Hgene	Tgene
	Gene symbol	BCL11B	HLA-C
	Gene ID	64919	3107
	Gene name	BAF chromatin remodeling complex subunit BCL11B	major histocompatibility complex, class I, C
	Synonyms	ATL1\|ATL1-alpha\|ATL1-beta\|ATL1-delta\|ATL1-gamma\|CTIP-2\|CTIP2\|IDDFSTA\|IMD49\|RIT1\|ZNF856B\|hRIT1-alpha	D6S204\|HLA-JY3\|HLAC\|HLC-C\|MHC\|PSORS1
	Cytomap	14q32.2	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	B-cell lymphoma/leukemia 11BB cell CLL/lymphoma 11BB-cell CLL/lymphoma 11B (zinc finger protein)B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion proteinB-cell lymphoma/leukaemia 11BBCL-11BBCL11B, BAF complex componentBCL11B/TRDC	HLA class I histocompatibility antigen, C alpha chainHLA-C alpha chainHLA-C antigenMHC class I antigen heavy chain HLA-Chuman leukocyte antigen-C alpha chainmajor histocompatibility antigen HLA-C
	Modification date	20200313	20200327
	UniProtAcc	Q9C0K0	P10321
	Ensembl transtripts involved in fusion gene	ENST00000357195, ENST00000345514, ENST00000443726,	ENST00000383329, ENST00000376228, ENST00000423509, ENST00000430940, ENST00000422726, ENST00000424832, ENST00000458192, ENST00000422921, ENST00000456487, ENST00000420206, ENST00000495725, ENST00000419135, ENST00000433153, ENST00000429840, ENST00000457903, ENST00000479546, ENST00000400395, ENST00000383323, ENST00000434884, ENST00000400394, ENST00000494871, ENST00000453809, ENST00000414249, ENST00000419590, ENST00000438171, ENST00000552865, ENST00000495898, ENST00000383483, ENST00000383487, ENST00000458668, ENST00000400341,
Fusion gene scores	* DoF score	6 X 8 X 2=96	7 X 7 X 2=98
	# samples	8	7
	** MAII score	log2(8/96*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BCL11B [Title/Abstract] AND HLA-C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	HLA-C(31239425)-BCL11B(99655805), # samples:1 BCL11B(99655805)-HLA-C(31239425), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across BCL11B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HLA-C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	EL582403	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+

Top

Fusion Gene ORF analysis for BCL11B-HLA-C

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000357195	ENST00000383329	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-3CDS	ENST00000357195	ENST00000376228	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000423509	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000430940	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000422726	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000424832	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000458192	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000422921	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000456487	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000420206	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000495725	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000419135	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000433153	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000429840	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000457903	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000479546	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000400395	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000383323	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000434884	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000400394	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000494871	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000453809	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000414249	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000419590	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000438171	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000552865	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000495898	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000383483	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000383487	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000458668	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000357195	ENST00000400341	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-3CDS	ENST00000345514	ENST00000383329	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-3CDS	ENST00000345514	ENST00000376228	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000423509	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000430940	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000422726	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000424832	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000458192	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000422921	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000456487	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000420206	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000495725	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000419135	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000433153	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000429840	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000457903	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000479546	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000400395	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000383323	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000434884	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000400394	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000494871	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000453809	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000414249	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000419590	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000438171	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000552865	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000495898	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000383483	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000383487	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000458668	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000345514	ENST00000400341	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-3CDS	ENST00000443726	ENST00000383329	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-3CDS	ENST00000443726	ENST00000376228	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000423509	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000430940	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000422726	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000424832	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000458192	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000422921	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000456487	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000420206	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000495725	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000419135	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000433153	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000429840	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000457903	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000479546	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000400395	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000383323	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000434884	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000400394	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000494871	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000453809	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000414249	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000419590	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000438171	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000552865	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000495898	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000383483	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000383487	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000458668	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+
intron-intron	ENST00000443726	ENST00000400341	BCL11B	chr14	99655805	+	HLA-C	chr6	31239425	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for BCL11B-HLA-C

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for BCL11B-HLA-C

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BCL11B Q9C0K0	HLA-C P10321
FUNCTION: Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250\|UniProtKB:Q99PV8, ECO:0000269\|PubMed:16809611, ECO:0000269\|PubMed:27959755}.	FUNCTION: Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity (PubMed:20972337, PubMed:24091323, PubMed:20439706, PubMed:11172028, PubMed:20104487, PubMed:28649982, PubMed:29312307). In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells (PubMed:16141329). In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary for placentation and overall fetal growth (PubMed:20972337, PubMed:24091323). During viral infection, may present viral peptides with low affinity for KIRs, impeding KIR-mediated inhibition through peptide antagonism and favoring lysis of infected cells (PubMed:20439706). Presents a restricted repertoire of viral peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-C-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected cells, particularly in chronic viral infection settings such as HIV-1 or CMV infection (PubMed:11172028, PubMed:20104487, PubMed:28649982). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (By similarity). Typically presents intracellular peptide antigens of 9 amino acids that arise from cytosolic proteolysis via proteasome. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9. Preferentially displays peptides having a restricted repertoire of hydrophobic or aromatic amino acids (Phe, Ile, Leu, Met, Val and Tyr) at the C-terminal anchor (PubMed:8265661, PubMed:25311805). {ECO:0000250\|UniProtKB:P04439, ECO:0000269\|PubMed:11172028, ECO:0000269\|PubMed:16141329, ECO:0000269\|PubMed:20104487, ECO:0000269\|PubMed:20439706, ECO:0000269\|PubMed:20972337, ECO:0000269\|PubMed:24091323, ECO:0000269\|PubMed:25311805, ECO:0000269\|PubMed:28649982, ECO:0000269\|PubMed:29312307, ECO:0000269\|PubMed:8265661}.; FUNCTION: ALLELE C01:02: The peptide-bound form interacts with KIR2DL2 and KIR2DL3 inhibitory receptors on NK cells. The low affinity peptides compete with the high affinity peptides impeding KIR-mediated inhibition and favoring lysis of infected cells (PubMed:20439706). Presents to CD8-positive T cells a CMV epitope derived from UL83/pp65 (RCPEMISVL), an immediate-early antigen necessary for initiating viral replication (PubMed:12947002). {ECO:0000269\|PubMed:12947002, ECO:0000269\|PubMed:20439706}.; FUNCTION: ALLELE C04:01: Presents a conserved HIV-1 epitope derived from env (SFNCGGEFF) to memory CD8-positive T cells, eliciting very strong IFNG responses (PubMed:20104487). Presents CMV epitope derived from UL83/pp65 (QYDPVAALF) to CD8-positive T cells, triggering T cell cytotoxic response (PubMed:12947002). {ECO:0000269\|PubMed:12947002, ECO:0000269\|PubMed:20104487}.; FUNCTION: ALLELE C05:01: Presents HIV-1 epitope derived from rev (SAEPVPLQL) to CD8-positive T cells, triggering T cell cytotoxic response. {ECO:0000269\|PubMed:11172028}.; FUNCTION: ALLELE C06:02: In trophoblasts, interacts with KIR2DS2 on uterine NK cells and triggers NK cell activation, including secretion of cytokines such as GMCSF that enhances trophoblast migration. {ECO:0000269\|PubMed:24091323}.; FUNCTION: ALLELE C07:02: Plays an important role in the control of chronic CMV infection. Presents immunodominant CMV epitopes derived from IE1 (LSEFCRVL and CRVLCCYVL) and UL28 (FRCPRRFCF), both antigens synthesized during immediate-early period of viral replication. Elicits a strong anti-viral CD8-positive T cell immune response that increases markedly with age. {ECO:0000269\|PubMed:29312307}.; FUNCTION: ALLELE C08:01: Presents viral epitopes derived from CMV UL83 (VVCAHELVC) and IAV M1 (GILGFVFTL), triggering CD8-positive T cell cytotoxic response. {ECO:0000269\|PubMed:12947002, ECO:0000269\|PubMed:24990997}.; FUNCTION: ALLELE C12:02: Presents CMV epitope derived from UL83 (VAFTSHEHF) to CD8-positive T cells. {ECO:0000269\|PubMed:12947002}.; FUNCTION: ALLELE C15:02: Presents CMV epitope derived from UL83 CC (VVCAHELVC) to CD8-positive T cells, triggering T cell cytotoxic response. {ECO:0000269\|PubMed:12947002}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for BCL11B-HLA-C

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for BCL11B-HLA-C

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BCL11B-HLA-C

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BCL11B-HLA-C

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	BCL11B	C4310656	IMMUNODEFICIENCY 49	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	BCL11B	C0024299	Lymphoma	1	CTD_human
Hgene	BCL11B	C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1	CTD_human
Hgene	BCL11B	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
Hgene	BCL11B	C4748152	INTELLECTUAL DEVELOPMENTAL DISORDER WITH SPEECH DELAY, DYSMORPHIC FACIES, AND T-CELL ABNORMALITIES	1	GENOMICS_ENGLAND
Tgene	HLA-C	C0030246	Pustulosis of Palms and Soles	2	CTD_human
Tgene	HLA-C	C0033860	Psoriasis	2	CTD_human
Tgene	HLA-C	C0036341	Schizophrenia	2	PSYGENET
Tgene	HLA-C	C0003872	Arthritis, Psoriatic	1	CTD_human
Tgene	HLA-C	C0006413	Burkitt Lymphoma	1	ORPHANET
Tgene	HLA-C	C0013221	Drug toxicity	1	CTD_human
Tgene	HLA-C	C0014518	Toxic Epidermal Necrolysis	1	CTD_human
Tgene	HLA-C	C0017638	Glioma	1	CTD_human
Tgene	HLA-C	C0038325	Stevens-Johnson Syndrome	1	CTD_human
Tgene	HLA-C	C0041755	Adverse reaction to drug	1	CTD_human
Tgene	HLA-C	C0259783	mixed gliomas	1	CTD_human
Tgene	HLA-C	C0524909	Hepatitis B, Chronic	1	CTD_human
Tgene	HLA-C	C0555198	Malignant Glioma	1	CTD_human
Tgene	HLA-C	C1274933	Drug-Induced Stevens Johnson Syndrome	1	CTD_human
Tgene	HLA-C	C1292769	Precursor B-cell lymphoblastic leukemia	1	ORPHANET
Tgene	HLA-C	C3658301	Mycoplasma-Induced Stevens-Johnson Syndrome	1	CTD_human
Tgene	HLA-C	C3658302	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum	1	CTD_human