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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TSPAN15-VPS26A (FusionGDB2 ID:94064)

Fusion Gene Summary for TSPAN15-VPS26A

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPAN15-VPS26A
Fusion gene ID: 94064
HgeneTgene
Gene symbol

TSPAN15

VPS26A

Gene ID

23555

9559

Gene nametetraspanin 15VPS26, retromer complex component A
Synonyms2700063A19Rik|NET-7|NET7|TM4SF15HB58|Hbeta58|PEP8A|VPS26
Cytomap

10q22.1

10q22.1

Type of geneprotein-codingprotein-coding
Descriptiontetraspanin-15tetraspan NET-7transmembrane 4 superfamily member 15transmembrane 4 superfamily member tetraspan NET-7tspan-15vacuolar protein sorting-associated protein 26AVPS26 retromer complex comonent Avacuolar protein sorting 26 homolog Avesicle protein sorting 26A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000373290, ENST00000459981, 
ENST00000373382, ENST00000263559, 
ENST00000395098, ENST00000546041, 
ENST00000490696, ENST00000541711, 
ENST00000489794, 
Fusion gene scores* DoF score8 X 10 X 4=32011 X 9 X 6=594
# samples 913
** MAII scorelog2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/594*10)=-2.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSPAN15 [Title/Abstract] AND VPS26A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTSPAN15(71211446)-VPS26A(70915568), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTSPAN15

GO:0045746

negative regulation of Notch signaling pathway

30463011


check buttonFusion gene breakpoints across TSPAN15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across VPS26A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A15S-01ATSPAN15chr10

71211446

+VPS26Achr10

70915568

+
ChimerDB4BRCATCGA-E2-A15STSPAN15chr10

71211446

+VPS26Achr10

70915567

+
ChimerDB4BRCATCGA-E2-A15S-01ATSPAN15chr10

71211446

+VPS26Achr10

70915568

+
ChimerDB4BRCATCGA-E2-A15S-01ATSPAN15chr10

71211446

-VPS26Achr10

70915568

+


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Fusion Gene ORF analysis for TSPAN15-VPS26A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373290ENST00000373382TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
In-frameENST00000373290ENST00000263559TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
In-frameENST00000373290ENST00000395098TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
In-frameENST00000373290ENST00000546041TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
5CDS-intronENST00000373290ENST00000490696TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
5CDS-intronENST00000373290ENST00000541711TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
5CDS-intronENST00000373290ENST00000489794TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
intron-3CDSENST00000459981ENST00000373382TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
intron-3CDSENST00000459981ENST00000263559TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
intron-3CDSENST00000459981ENST00000395098TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
intron-3CDSENST00000459981ENST00000546041TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
intron-intronENST00000459981ENST00000490696TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
intron-intronENST00000459981ENST00000541711TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
intron-intronENST00000459981ENST00000489794TSPAN15chr10

71211446

+VPS26Achr10

70915568

+
In-frameENST00000373290ENST00000373382TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
In-frameENST00000373290ENST00000263559TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
In-frameENST00000373290ENST00000395098TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
In-frameENST00000373290ENST00000546041TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
5CDS-intronENST00000373290ENST00000490696TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
5CDS-intronENST00000373290ENST00000541711TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
5CDS-intronENST00000373290ENST00000489794TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
intron-3CDSENST00000459981ENST00000373382TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
intron-3CDSENST00000459981ENST00000263559TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
intron-3CDSENST00000459981ENST00000395098TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
intron-3CDSENST00000459981ENST00000546041TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
intron-intronENST00000459981ENST00000490696TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
intron-intronENST00000459981ENST00000541711TSPAN15chr10

71211446

+VPS26Achr10

70915567

+
intron-intronENST00000459981ENST00000489794TSPAN15chr10

71211446

+VPS26Achr10

70915567

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373290TSPAN15chr1071211446+ENST00000373382VPS26Achr1070915568+26412181221048308
ENST00000373290TSPAN15chr1071211446+ENST00000263559VPS26Achr1070915568+26362181221048308
ENST00000373290TSPAN15chr1071211446+ENST00000395098VPS26Achr1070915568+2493218122820232
ENST00000373290TSPAN15chr1071211446+ENST00000546041VPS26Achr1070915568+13052181221048308
ENST00000373290TSPAN15chr1071211446+ENST00000373382VPS26Achr1070915567+26412181221048308
ENST00000373290TSPAN15chr1071211446+ENST00000263559VPS26Achr1070915567+26362181221048308
ENST00000373290TSPAN15chr1071211446+ENST00000395098VPS26Achr1070915567+2493218122820232
ENST00000373290TSPAN15chr1071211446+ENST00000546041VPS26Achr1070915567+13052181221048308

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373290ENST00000373382TSPAN15chr1071211446+VPS26Achr1070915568+0.0001636310.9998363
ENST00000373290ENST00000263559TSPAN15chr1071211446+VPS26Achr1070915568+0.0001638320.9998361
ENST00000373290ENST00000395098TSPAN15chr1071211446+VPS26Achr1070915568+0.0003421870.99965787
ENST00000373290ENST00000546041TSPAN15chr1071211446+VPS26Achr1070915568+0.000603630.9993963
ENST00000373290ENST00000373382TSPAN15chr1071211446+VPS26Achr1070915567+0.0001636310.9998363
ENST00000373290ENST00000263559TSPAN15chr1071211446+VPS26Achr1070915567+0.0001638320.9998361
ENST00000373290ENST00000395098TSPAN15chr1071211446+VPS26Achr1070915567+0.0003421870.99965787
ENST00000373290ENST00000546041TSPAN15chr1071211446+VPS26Achr1070915567+0.000603630.9993963

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Fusion Genomic Features for TSPAN15-VPS26A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TSPAN15chr1071211446+VPS26Achr1070915567+9.93E-050.9999007
TSPAN15chr1071211446+VPS26Achr1070915567+9.93E-050.9999007
TSPAN15chr1071211446+VPS26Achr1070915567+9.93E-050.9999007
TSPAN15chr1071211446+VPS26Achr1070915567+9.93E-050.9999007

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TSPAN15-VPS26A


check button Go to

FGviewer for the breakpoints of chr10:71211446-chr10:70915568

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSPAN15chr10:71211446chr10:70915567ENST00000373290+181_2332.0295.0Topological domainCytoplasmic
HgeneTSPAN15chr10:71211446chr10:70915568ENST00000373290+181_2332.0295.0Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSPAN15chr10:71211446chr10:70915567ENST00000373290+18115_23532.0295.0Topological domainExtracellular
HgeneTSPAN15chr10:71211446chr10:70915567ENST00000373290+18257_29432.0295.0Topological domainCytoplasmic
HgeneTSPAN15chr10:71211446chr10:70915567ENST00000373290+1845_6232.0295.0Topological domainExtracellular
HgeneTSPAN15chr10:71211446chr10:70915567ENST00000373290+1884_9332.0295.0Topological domainCytoplasmic
HgeneTSPAN15chr10:71211446chr10:70915568ENST00000373290+18115_23532.0295.0Topological domainExtracellular
HgeneTSPAN15chr10:71211446chr10:70915568ENST00000373290+18257_29432.0295.0Topological domainCytoplasmic
HgeneTSPAN15chr10:71211446chr10:70915568ENST00000373290+1845_6232.0295.0Topological domainExtracellular
HgeneTSPAN15chr10:71211446chr10:70915568ENST00000373290+1884_9332.0295.0Topological domainCytoplasmic
HgeneTSPAN15chr10:71211446chr10:70915567ENST00000373290+18236_25632.0295.0TransmembraneHelical
HgeneTSPAN15chr10:71211446chr10:70915567ENST00000373290+1824_4432.0295.0TransmembraneHelical
HgeneTSPAN15chr10:71211446chr10:70915567ENST00000373290+1863_8332.0295.0TransmembraneHelical
HgeneTSPAN15chr10:71211446chr10:70915567ENST00000373290+1894_11432.0295.0TransmembraneHelical
HgeneTSPAN15chr10:71211446chr10:70915568ENST00000373290+18236_25632.0295.0TransmembraneHelical
HgeneTSPAN15chr10:71211446chr10:70915568ENST00000373290+1824_4432.0295.0TransmembraneHelical
HgeneTSPAN15chr10:71211446chr10:70915568ENST00000373290+1863_8332.0295.0TransmembraneHelical
HgeneTSPAN15chr10:71211446chr10:70915568ENST00000373290+1894_11432.0295.0TransmembraneHelical


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Fusion Gene Sequence for TSPAN15-VPS26A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000373290_ENST00000373382_TCGA-E2-A15S-01A_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915568_length(transcript)=2641nt_BP=218nt
CGGAGAGAACGCCGGTGGCGGGGCTGGTAGCCCGGCAGCCGCAGGTGGGGCCACGAGCGCTGGCTGAGGGACCGAGCCGGAGAGCCCCGG
AGCCCCCGTAACCCGCGCGGGGAGCGCCCAGGATGCCGCGCGGGGACTCGGAGCAGGTGCGCTACTGCGCGCGCTTCTCCTACCTCTGGC
TCAAGTTTTCACTTATCATCTATTCCACCGTGTTCTGGGTAAACCTAGCCTTTAAGCAACCTGGAAAGAGGCTAGAACACCAAGGAATTA
GAATTGAATTTGTAGGTCAAATTGAACTTTTCAATGACAAGAGTAATACTCATGAATTTGTAAACCTAGTGAAAGAACTAGCCTTACCTG
GAGAACTGACTCAGAGCAGAAGTTATGATTTTGAATTTATGCAAGTTGAAAAGCCATATGAATCTTACATCGGTGCCAATGTCCGCTTGA
GGTATTTTCTTAAAGTGACAATAGTGAGAAGACTGACAGATTTGGTAAAAGAGTATGATCTTATTGTTCACCAGCTTGCCACCTATCCTG
ATGTTAACAACTCTATTAAGATGGAAGTGGGCATTGAAGATTGTCTACATATAGAATTTGAATATAATAAATCAAAGTATCATTTAAAGG
ATGTGATTGTTGGAAAAATTTACTTCTTATTAGTAAGAATAAAAATACAACATATGGAGTTACAGCTGATCAAAAAAGAGATCACAGGAA
TTGGACCCAGTACCACAACAGAAACAGAAACAATCGCCAAATATGAAATAATGGATGGTGCACCAGTAAAAGGTGAATCAATTCCAATAA
GGCTATTTTTAGCAGGATATGACCCAACTCCAACAATGAGAGATGTGAACAAAAAATTTTCAGTAAGGTACTTTTTGAATTTAGTGCTTG
TTGATGAGGAAGACCGGAGGTACTTCAAACAGCAGGAGATAATTTTATGGAGAAAAGCTCCTGAAAAACTGAGGAAACAGAGAACAAACT
TTCACCAGCGATTTGAATCTCCAGAATCACAGGCATCTGCCGAACAGCCTGAAATGTGAACTGAACAGGAGAAAAAAAGAAAAGCAAAAA
ACTCCTGTAACCCTTGAGATTAAGTTCAGCAGGTTAAAGATGGTTGCAGCTGGAGGGGGCGGAAAAAGGCCAAAACTCCATATATGTTAG
TCTTCCTTTATCTTACAGCGCAGCATTTATTTTATGATATAATGAAATGTTCGTTCATGTATATACATTTTTAAAAGTGCTTTCTTTGAA
ACACTGGAACTTTGTTAAGCTGCCTTTTTTTTTTTAACTTCCTACTTTGATGATAAGCACTCAGATATATATCAGCGTAAACATGAAAAA
TTTTCATGTGAGTAGGCTGGTATTTGTAATTTTGCTTTCTTTCTGCATAATGTTGATTATAAATCCTCTCTTTTCAGGCTAATGATTACC
TCTTATTCTCTACATGCAAAAAATTAAATATTTTGTGTTCAAATAAAATTAGAAAACCTGAGTGGCCTCTTGTGTCCTGCAGAGATTTAA
AACATGGCATCTCAATATTTTTGAGAACTACATTTGTTTTTAACATATGTGTTTGAGAAAAGCATATGGAGTGTTTCACCGCAGGCACTT
CTGAGTACCATTCCATGGCTTCCAGAATTTTATCCTCTTTGAGGTCTTCTGTGCTATGAATATTAGATTTCTTTCCCCAAGGGATTATGT
GGCAGGTCATTATGGCCTTCTTTTTTTTGGCCATATTAAGTAACAGTTTTGCTATATTCCAGTAGTACCGTTGTGTGTTTTCTGCAATGT
GGAGTTGACTTAGCTTGGCATTTTAGATTTGTTAAAACTATTTTTTCCATAAATACTTTGAAACATATTTATATATTTCAATTTAAGGAA
TCTTTTTGCCATGTGTATGCAAATATTATTTTCTTCATACATTCATTTTCTTTTCAGGGGAAAATTTTGGGATGGGGGACTCAGGAGGAC
CTGTGAAGCATGTAGTTATCTAGATCTGGGTAATTTCATGTTTATTAAACTCGAACTTTGGCTAGTTAAACTCATATTGAAACTTCATCT
AGTCTCTTAATTTTTTAACACTAAATTCAAGTCATTTGTTTTAAGTCTCTAAAAAAGAAGATTGCAGTCATCCATTCATATGCATGGGGT
CTGATCGCAAATACACTAAATGTGGAGTGTAGGAACCAAAATGAAACCTGCTGTATGGAAACTACTTTCACTTATGGTTCATTGGTTTTT
GTACCAATATTTTTTATGCACTTCAGTGCAAGTCTTGTCAGTTAACCTTACTTTATGAGTAAGCTAAATAACCCAAATTACATTTCTTTA
AACCTGTTTTACTACTATGGCACTTTGATAAAATGGTCAGGAACCAACTTTACTGGCAAAAGGGTCCATGTACCACCATGTGCTGGAGCA
TCTGTTCTACATGTGGATATCTATGAATGGTAATGTTTTCCTTCATGTAAGTGCCTATTCAGAGTTTCAGAATTTTAAAATGCCAAATAT
TTTCATGGTCATTTGCATGTAGTAAGCCAGAAAATATTCAAAGAGATTTTGAAAACCAATTGTATTTAACCAGCCTCAAATTGTGCAACC

>In-frame_ENST00000373290_ENST00000373382_TCGA-E2-A15S-01A_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915568_length(amino acids)=308AA_start in transcript=122_stop in transcript=1048
MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDF
EFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLL
VRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQ

--------------------------------------------------------------
>In-frame_ENST00000373290_ENST00000263559_TCGA-E2-A15S-01A_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915568_length(transcript)=2636nt_BP=218nt
CGGAGAGAACGCCGGTGGCGGGGCTGGTAGCCCGGCAGCCGCAGGTGGGGCCACGAGCGCTGGCTGAGGGACCGAGCCGGAGAGCCCCGG
AGCCCCCGTAACCCGCGCGGGGAGCGCCCAGGATGCCGCGCGGGGACTCGGAGCAGGTGCGCTACTGCGCGCGCTTCTCCTACCTCTGGC
TCAAGTTTTCACTTATCATCTATTCCACCGTGTTCTGGGTAAACCTAGCCTTTAAGCAACCTGGAAAGAGGCTAGAACACCAAGGAATTA
GAATTGAATTTGTAGGTCAAATTGAACTTTTCAATGACAAGAGTAATACTCATGAATTTGTAAACCTAGTGAAAGAACTAGCCTTACCTG
GAGAACTGACTCAGAGCAGAAGTTATGATTTTGAATTTATGCAAGTTGAAAAGCCATATGAATCTTACATCGGTGCCAATGTCCGCTTGA
GGTATTTTCTTAAAGTGACAATAGTGAGAAGACTGACAGATTTGGTAAAAGAGTATGATCTTATTGTTCACCAGCTTGCCACCTATCCTG
ATGTTAACAACTCTATTAAGATGGAAGTGGGCATTGAAGATTGTCTACATATAGAATTTGAATATAATAAATCAAAGTATCATTTAAAGG
ATGTGATTGTTGGAAAAATTTACTTCTTATTAGTAAGAATAAAAATACAACATATGGAGTTACAGCTGATCAAAAAAGAGATCACAGGAA
TTGGACCCAGTACCACAACAGAAACAGAAACAATCGCCAAATATGAAATAATGGATGGTGCACCAGTAAAAGGTGAATCAATTCCAATAA
GGCTATTTTTAGCAGGATATGACCCAACTCCAACAATGAGAGATGTGAACAAAAAATTTTCAGTAAGGTACTTTTTGAATTTAGTGCTTG
TTGATGAGGAAGACCGGAGGTACTTCAAACAGCAGGAGATAATTTTATGGAGAAAAGCTCCTGAAAAACTGAGGAAACAGAGAACAAACT
TTCACCAGCGATTTGAATCTCCAGAATCACAGGCATCTGCCGAACAGCCTGAAATGTGAACTGAACAGGAGAAAAAAAGAAAAGCAAAAA
ACTCCTGTAACCCTTGAGATTAAGTTCAGCAGGTTAAAGATGGTTGCAGCTGGAGGGGGCGGAAAAAGGCCAAAACTCCATATATGTTAG
TCTTCCTTTATCTTACAGCGCAGCATTTATTTTATGATATAATGAAATGTTCGTTCATGTATATACATTTTTAAAAGTGCTTTCTTTGAA
ACACTGGAACTTTGTTAAGCTGCCTTTTTTTTTTTAACTTCCTACTTTGATGATAAGCACTCAGATATATATCAGCGTAAACATGAAAAA
TTTTCATGTGAGTAGGCTGGTATTTGTAATTTTGCTTTCTTTCTGCATAATGTTGATTATAAATCCTCTCTTTTCAGGCTAATGATTACC
TCTTATTCTCTACATGCAAAAAATTAAATATTTTGTGTTCAAATAAAATTAGAAAACCTGAGTGGCCTCTTGTGTCCTGCAGAGATTTAA
AACATGGCATCTCAATATTTTTGAGAACTACATTTGTTTTTAACATATGTGTTTGAGAAAAGCATATGGAGTGTTTCACCGCAGGCACTT
CTGAGTACCATTCCATGGCTTCCAGAATTTTATCCTCTTTGAGGTCTTCTGTGCTATGAATATTAGATTTCTTTCCCCAAGGGATTATGT
GGCAGGTCATTATGGCCTTCTTTTTTTTGGCCATATTAAGTAACAGTTTTGCTATATTCCAGTAGTACCGTTGTGTGTTTTCTGCAATGT
GGAGTTGACTTAGCTTGGCATTTTAGATTTGTTAAAACTATTTTTTCCATAAATACTTTGAAACATATTTATATATTTCAATTTAAGGAA
TCTTTTTGCCATGTGTATGCAAATATTATTTTCTTCATACATTCATTTTCTTTTCAGGGGAAAATTTTGGGATGGGGGACTCAGGAGGAC
CTGTGAAGCATGTAGTTATCTAGATCTGGGTAATTTCATGTTTATTAAACTCGAACTTTGGCTAGTTAAACTCATATTGAAACTTCATCT
AGTCTCTTAATTTTTTAACACTAAATTCAAGTCATTTGTTTTAAGTCTCTAAAAAAGAAGATTGCAGTCATCCATTCATATGCATGGGGT
CTGATCGCAAATACACTAAATGTGGAGTGTAGGAACCAAAATGAAACCTGCTGTATGGAAACTACTTTCACTTATGGTTCATTGGTTTTT
GTACCAATATTTTTTATGCACTTCAGTGCAAGTCTTGTCAGTTAACCTTACTTTATGAGTAAGCTAAATAACCCAAATTACATTTCTTTA
AACCTGTTTTACTACTATGGCACTTTGATAAAATGGTCAGGAACCAACTTTACTGGCAAAAGGGTCCATGTACCACCATGTGCTGGAGCA
TCTGTTCTACATGTGGATATCTATGAATGGTAATGTTTTCCTTCATGTAAGTGCCTATTCAGAGTTTCAGAATTTTAAAATGCCAAATAT
TTTCATGGTCATTTGCATGTAGTAAGCCAGAAAATATTCAAAGAGATTTTGAAAACCAATTGTATTTAACCAGCCTCAAATTGTGCAACC

>In-frame_ENST00000373290_ENST00000263559_TCGA-E2-A15S-01A_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915568_length(amino acids)=308AA_start in transcript=122_stop in transcript=1048
MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDF
EFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLL
VRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQ

--------------------------------------------------------------
>In-frame_ENST00000373290_ENST00000395098_TCGA-E2-A15S-01A_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915568_length(transcript)=2493nt_BP=218nt
CGGAGAGAACGCCGGTGGCGGGGCTGGTAGCCCGGCAGCCGCAGGTGGGGCCACGAGCGCTGGCTGAGGGACCGAGCCGGAGAGCCCCGG
AGCCCCCGTAACCCGCGCGGGGAGCGCCCAGGATGCCGCGCGGGGACTCGGAGCAGGTGCGCTACTGCGCGCGCTTCTCCTACCTCTGGC
TCAAGTTTTCACTTATCATCTATTCCACCGTGTTCTGGGTAAACCTAGCCTTTAAGCAACCTGGAAAGAGGCTAGAACACCAAGGAATTA
GAATTGAATTTGTAGGTCAAATTGAACTTTTCAATGACAAGAGTAATACTCATGAATTTGTAAACCTAGTGAAAGAACTAGCCTTACCTG
GAGAACTGACTCAGAGCAGAAGTTATGATTTTGAATTTATGCAAGTTGAAAAGCCATATGAATCTTACATCGGTGCCAATGTCCGCTTGA
GGTATTTTCTTAAAGTGACAATAGTGAGAAGACTGACAGATTTGGTAAAAGAGTATGATCTTATTGTTCACCAGCTTGCCACCTATCCTG
ATGTTAACAACTCTATTAAGATGGAAGTGGGCATTGAAGATTGTCTACATATAGAATTTGAATATAATAAATCAAAGTATCATTTAAAGG
ATGTGATTGTTGGAAAAATTTACTTCTTATTAGTAAGAATAAAAATACAACATATGGAGTTACAGCTGATCAAAAAAGAGATCACAGGAA
TTGGACCCAGTACCACAACAGAAACAGAAACAATCGCCAAATATGAAATAATGGATGGTGCACCAGTAAAAGGAGATAATTTTATGGAGA
AAAGCTCCTGAAAAACTGAGGAAACAGAGAACAAACTTTCACCAGCGATTTGAATCTCCAGAATCACAGGCATCTGCCGAACAGCCTGAA
ATGTGAACTGAACAGGAGAAAAAAAGAAAAGCAAAAAACTCCTGTAACCCTTGAGATTAAGTTCAGCAGGTTAAAGATGGTTGCAGCTGG
AGGGGGCGGAAAAAGGCCAAAACTCCATATATGTTAGTCTTCCTTTATCTTACAGCGCAGCATTTATTTTATGATATAATGAAATGTTCG
TTCATGTATATACATTTTTAAAAGTGCTTTCTTTGAAACACTGGAACTTTGTTAAGCTGCCTTTTTTTTTTTAACTTCCTACTTTGATGA
TAAGCACTCAGATATATATCAGCGTAAACATGAAAAATTTTCATGTGAGTAGGCTGGTATTTGTAATTTTGCTTTCTTTCTGCATAATGT
TGATTATAAATCCTCTCTTTTCAGGCTAATGATTACCTCTTATTCTCTACATGCAAAAAATTAAATATTTTGTGTTCAAATAAAATTAGA
AAACCTGAGTGGCCTCTTGTGTCCTGCAGAGATTTAAAACATGGCATCTCAATATTTTTGAGAACTACATTTGTTTTTAACATATGTGTT
TGAGAAAAGCATATGGAGTGTTTCACCGCAGGCACTTCTGAGTACCATTCCATGGCTTCCAGAATTTTATCCTCTTTGAGGTCTTCTGTG
CTATGAATATTAGATTTCTTTCCCCAAGGGATTATGTGGCAGGTCATTATGGCCTTCTTTTTTTTGGCCATATTAAGTAACAGTTTTGCT
ATATTCCAGTAGTACCGTTGTGTGTTTTCTGCAATGTGGAGTTGACTTAGCTTGGCATTTTAGATTTGTTAAAACTATTTTTTCCATAAA
TACTTTGAAACATATTTATATATTTCAATTTAAGGAATCTTTTTGCCATGTGTATGCAAATATTATTTTCTTCATACATTCATTTTCTTT
TCAGGGGAAAATTTTGGGATGGGGGACTCAGGAGGACCTGTGAAGCATGTAGTTATCTAGATCTGGGTAATTTCATGTTTATTAAACTCG
AACTTTGGCTAGTTAAACTCATATTGAAACTTCATCTAGTCTCTTAATTTTTTAACACTAAATTCAAGTCATTTGTTTTAAGTCTCTAAA
AAAGAAGATTGCAGTCATCCATTCATATGCATGGGGTCTGATCGCAAATACACTAAATGTGGAGTGTAGGAACCAAAATGAAACCTGCTG
TATGGAAACTACTTTCACTTATGGTTCATTGGTTTTTGTACCAATATTTTTTATGCACTTCAGTGCAAGTCTTGTCAGTTAACCTTACTT
TATGAGTAAGCTAAATAACCCAAATTACATTTCTTTAAACCTGTTTTACTACTATGGCACTTTGATAAAATGGTCAGGAACCAACTTTAC
TGGCAAAAGGGTCCATGTACCACCATGTGCTGGAGCATCTGTTCTACATGTGGATATCTATGAATGGTAATGTTTTCCTTCATGTAAGTG
CCTATTCAGAGTTTCAGAATTTTAAAATGCCAAATATTTTCATGGTCATTTGCATGTAGTAAGCCAGAAAATATTCAAAGAGATTTTGAA

>In-frame_ENST00000373290_ENST00000395098_TCGA-E2-A15S-01A_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915568_length(amino acids)=232AA_start in transcript=122_stop in transcript=820
MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDF
EFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLL

--------------------------------------------------------------
>In-frame_ENST00000373290_ENST00000546041_TCGA-E2-A15S-01A_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915568_length(transcript)=1305nt_BP=218nt
CGGAGAGAACGCCGGTGGCGGGGCTGGTAGCCCGGCAGCCGCAGGTGGGGCCACGAGCGCTGGCTGAGGGACCGAGCCGGAGAGCCCCGG
AGCCCCCGTAACCCGCGCGGGGAGCGCCCAGGATGCCGCGCGGGGACTCGGAGCAGGTGCGCTACTGCGCGCGCTTCTCCTACCTCTGGC
TCAAGTTTTCACTTATCATCTATTCCACCGTGTTCTGGGTAAACCTAGCCTTTAAGCAACCTGGAAAGAGGCTAGAACACCAAGGAATTA
GAATTGAATTTGTAGGTCAAATTGAACTTTTCAATGACAAGAGTAATACTCATGAATTTGTAAACCTAGTGAAAGAACTAGCCTTACCTG
GAGAACTGACTCAGAGCAGAAGTTATGATTTTGAATTTATGCAAGTTGAAAAGCCATATGAATCTTACATCGGTGCCAATGTCCGCTTGA
GGTATTTTCTTAAAGTGACAATAGTGAGAAGACTGACAGATTTGGTAAAAGAGTATGATCTTATTGTTCACCAGCTTGCCACCTATCCTG
ATGTTAACAACTCTATTAAGATGGAAGTGGGCATTGAAGATTGTCTACATATAGAATTTGAATATAATAAATCAAAGTATCATTTAAAGG
ATGTGATTGTTGGAAAAATTTACTTCTTATTAGTAAGAATAAAAATACAACATATGGAGTTACAGCTGATCAAAAAAGAGATCACAGGAA
TTGGACCCAGTACCACAACAGAAACAGAAACAATCGCCAAATATGAAATAATGGATGGTGCACCAGTAAAAGGTGAATCAATTCCAATAA
GGCTATTTTTAGCAGGATATGACCCAACTCCAACAATGAGAGATGTGAACAAAAAATTTTCAGTAAGGTACTTTTTGAATTTAGTGCTTG
TTGATGAGGAAGACCGGAGGTACTTCAAACAGCAGGAGATAATTTTATGGAGAAAAGCTCCTGAAAAACTGAGGAAACAGAGAACAAACT
TTCACCAGCGATTTGAATCTCCAGAATCACAGGCATCTGCCGAACAGCCTGAAATGTGAACTGAACAGGAGAAAAAAAGAAAAGCAAAAA
ACTCCTGTAACCCTTGAGATTAAGTTCAGCAGGTTAAAGATGGTTGCAGCTGGAGGGGGCGGAAAAAGGCCAAAACTCCATATATGTTAG
TCTTCCTTTATCTTACAGCGCAGCATTTATTTTATGATATAATGAAATGTTCGTTCATGTATATACATTTTTAAAAGTGCTTTCTTTGAA

>In-frame_ENST00000373290_ENST00000546041_TCGA-E2-A15S-01A_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915568_length(amino acids)=308AA_start in transcript=122_stop in transcript=1048
MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDF
EFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLL
VRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQ

--------------------------------------------------------------
>In-frame_ENST00000373290_ENST00000373382_TCGA-E2-A15S_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915567_length(transcript)=2641nt_BP=218nt
CGGAGAGAACGCCGGTGGCGGGGCTGGTAGCCCGGCAGCCGCAGGTGGGGCCACGAGCGCTGGCTGAGGGACCGAGCCGGAGAGCCCCGG
AGCCCCCGTAACCCGCGCGGGGAGCGCCCAGGATGCCGCGCGGGGACTCGGAGCAGGTGCGCTACTGCGCGCGCTTCTCCTACCTCTGGC
TCAAGTTTTCACTTATCATCTATTCCACCGTGTTCTGGGTAAACCTAGCCTTTAAGCAACCTGGAAAGAGGCTAGAACACCAAGGAATTA
GAATTGAATTTGTAGGTCAAATTGAACTTTTCAATGACAAGAGTAATACTCATGAATTTGTAAACCTAGTGAAAGAACTAGCCTTACCTG
GAGAACTGACTCAGAGCAGAAGTTATGATTTTGAATTTATGCAAGTTGAAAAGCCATATGAATCTTACATCGGTGCCAATGTCCGCTTGA
GGTATTTTCTTAAAGTGACAATAGTGAGAAGACTGACAGATTTGGTAAAAGAGTATGATCTTATTGTTCACCAGCTTGCCACCTATCCTG
ATGTTAACAACTCTATTAAGATGGAAGTGGGCATTGAAGATTGTCTACATATAGAATTTGAATATAATAAATCAAAGTATCATTTAAAGG
ATGTGATTGTTGGAAAAATTTACTTCTTATTAGTAAGAATAAAAATACAACATATGGAGTTACAGCTGATCAAAAAAGAGATCACAGGAA
TTGGACCCAGTACCACAACAGAAACAGAAACAATCGCCAAATATGAAATAATGGATGGTGCACCAGTAAAAGGTGAATCAATTCCAATAA
GGCTATTTTTAGCAGGATATGACCCAACTCCAACAATGAGAGATGTGAACAAAAAATTTTCAGTAAGGTACTTTTTGAATTTAGTGCTTG
TTGATGAGGAAGACCGGAGGTACTTCAAACAGCAGGAGATAATTTTATGGAGAAAAGCTCCTGAAAAACTGAGGAAACAGAGAACAAACT
TTCACCAGCGATTTGAATCTCCAGAATCACAGGCATCTGCCGAACAGCCTGAAATGTGAACTGAACAGGAGAAAAAAAGAAAAGCAAAAA
ACTCCTGTAACCCTTGAGATTAAGTTCAGCAGGTTAAAGATGGTTGCAGCTGGAGGGGGCGGAAAAAGGCCAAAACTCCATATATGTTAG
TCTTCCTTTATCTTACAGCGCAGCATTTATTTTATGATATAATGAAATGTTCGTTCATGTATATACATTTTTAAAAGTGCTTTCTTTGAA
ACACTGGAACTTTGTTAAGCTGCCTTTTTTTTTTTAACTTCCTACTTTGATGATAAGCACTCAGATATATATCAGCGTAAACATGAAAAA
TTTTCATGTGAGTAGGCTGGTATTTGTAATTTTGCTTTCTTTCTGCATAATGTTGATTATAAATCCTCTCTTTTCAGGCTAATGATTACC
TCTTATTCTCTACATGCAAAAAATTAAATATTTTGTGTTCAAATAAAATTAGAAAACCTGAGTGGCCTCTTGTGTCCTGCAGAGATTTAA
AACATGGCATCTCAATATTTTTGAGAACTACATTTGTTTTTAACATATGTGTTTGAGAAAAGCATATGGAGTGTTTCACCGCAGGCACTT
CTGAGTACCATTCCATGGCTTCCAGAATTTTATCCTCTTTGAGGTCTTCTGTGCTATGAATATTAGATTTCTTTCCCCAAGGGATTATGT
GGCAGGTCATTATGGCCTTCTTTTTTTTGGCCATATTAAGTAACAGTTTTGCTATATTCCAGTAGTACCGTTGTGTGTTTTCTGCAATGT
GGAGTTGACTTAGCTTGGCATTTTAGATTTGTTAAAACTATTTTTTCCATAAATACTTTGAAACATATTTATATATTTCAATTTAAGGAA
TCTTTTTGCCATGTGTATGCAAATATTATTTTCTTCATACATTCATTTTCTTTTCAGGGGAAAATTTTGGGATGGGGGACTCAGGAGGAC
CTGTGAAGCATGTAGTTATCTAGATCTGGGTAATTTCATGTTTATTAAACTCGAACTTTGGCTAGTTAAACTCATATTGAAACTTCATCT
AGTCTCTTAATTTTTTAACACTAAATTCAAGTCATTTGTTTTAAGTCTCTAAAAAAGAAGATTGCAGTCATCCATTCATATGCATGGGGT
CTGATCGCAAATACACTAAATGTGGAGTGTAGGAACCAAAATGAAACCTGCTGTATGGAAACTACTTTCACTTATGGTTCATTGGTTTTT
GTACCAATATTTTTTATGCACTTCAGTGCAAGTCTTGTCAGTTAACCTTACTTTATGAGTAAGCTAAATAACCCAAATTACATTTCTTTA
AACCTGTTTTACTACTATGGCACTTTGATAAAATGGTCAGGAACCAACTTTACTGGCAAAAGGGTCCATGTACCACCATGTGCTGGAGCA
TCTGTTCTACATGTGGATATCTATGAATGGTAATGTTTTCCTTCATGTAAGTGCCTATTCAGAGTTTCAGAATTTTAAAATGCCAAATAT
TTTCATGGTCATTTGCATGTAGTAAGCCAGAAAATATTCAAAGAGATTTTGAAAACCAATTGTATTTAACCAGCCTCAAATTGTGCAACC

>In-frame_ENST00000373290_ENST00000373382_TCGA-E2-A15S_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915567_length(amino acids)=308AA_start in transcript=122_stop in transcript=1048
MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDF
EFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLL
VRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQ

--------------------------------------------------------------
>In-frame_ENST00000373290_ENST00000263559_TCGA-E2-A15S_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915567_length(transcript)=2636nt_BP=218nt
CGGAGAGAACGCCGGTGGCGGGGCTGGTAGCCCGGCAGCCGCAGGTGGGGCCACGAGCGCTGGCTGAGGGACCGAGCCGGAGAGCCCCGG
AGCCCCCGTAACCCGCGCGGGGAGCGCCCAGGATGCCGCGCGGGGACTCGGAGCAGGTGCGCTACTGCGCGCGCTTCTCCTACCTCTGGC
TCAAGTTTTCACTTATCATCTATTCCACCGTGTTCTGGGTAAACCTAGCCTTTAAGCAACCTGGAAAGAGGCTAGAACACCAAGGAATTA
GAATTGAATTTGTAGGTCAAATTGAACTTTTCAATGACAAGAGTAATACTCATGAATTTGTAAACCTAGTGAAAGAACTAGCCTTACCTG
GAGAACTGACTCAGAGCAGAAGTTATGATTTTGAATTTATGCAAGTTGAAAAGCCATATGAATCTTACATCGGTGCCAATGTCCGCTTGA
GGTATTTTCTTAAAGTGACAATAGTGAGAAGACTGACAGATTTGGTAAAAGAGTATGATCTTATTGTTCACCAGCTTGCCACCTATCCTG
ATGTTAACAACTCTATTAAGATGGAAGTGGGCATTGAAGATTGTCTACATATAGAATTTGAATATAATAAATCAAAGTATCATTTAAAGG
ATGTGATTGTTGGAAAAATTTACTTCTTATTAGTAAGAATAAAAATACAACATATGGAGTTACAGCTGATCAAAAAAGAGATCACAGGAA
TTGGACCCAGTACCACAACAGAAACAGAAACAATCGCCAAATATGAAATAATGGATGGTGCACCAGTAAAAGGTGAATCAATTCCAATAA
GGCTATTTTTAGCAGGATATGACCCAACTCCAACAATGAGAGATGTGAACAAAAAATTTTCAGTAAGGTACTTTTTGAATTTAGTGCTTG
TTGATGAGGAAGACCGGAGGTACTTCAAACAGCAGGAGATAATTTTATGGAGAAAAGCTCCTGAAAAACTGAGGAAACAGAGAACAAACT
TTCACCAGCGATTTGAATCTCCAGAATCACAGGCATCTGCCGAACAGCCTGAAATGTGAACTGAACAGGAGAAAAAAAGAAAAGCAAAAA
ACTCCTGTAACCCTTGAGATTAAGTTCAGCAGGTTAAAGATGGTTGCAGCTGGAGGGGGCGGAAAAAGGCCAAAACTCCATATATGTTAG
TCTTCCTTTATCTTACAGCGCAGCATTTATTTTATGATATAATGAAATGTTCGTTCATGTATATACATTTTTAAAAGTGCTTTCTTTGAA
ACACTGGAACTTTGTTAAGCTGCCTTTTTTTTTTTAACTTCCTACTTTGATGATAAGCACTCAGATATATATCAGCGTAAACATGAAAAA
TTTTCATGTGAGTAGGCTGGTATTTGTAATTTTGCTTTCTTTCTGCATAATGTTGATTATAAATCCTCTCTTTTCAGGCTAATGATTACC
TCTTATTCTCTACATGCAAAAAATTAAATATTTTGTGTTCAAATAAAATTAGAAAACCTGAGTGGCCTCTTGTGTCCTGCAGAGATTTAA
AACATGGCATCTCAATATTTTTGAGAACTACATTTGTTTTTAACATATGTGTTTGAGAAAAGCATATGGAGTGTTTCACCGCAGGCACTT
CTGAGTACCATTCCATGGCTTCCAGAATTTTATCCTCTTTGAGGTCTTCTGTGCTATGAATATTAGATTTCTTTCCCCAAGGGATTATGT
GGCAGGTCATTATGGCCTTCTTTTTTTTGGCCATATTAAGTAACAGTTTTGCTATATTCCAGTAGTACCGTTGTGTGTTTTCTGCAATGT
GGAGTTGACTTAGCTTGGCATTTTAGATTTGTTAAAACTATTTTTTCCATAAATACTTTGAAACATATTTATATATTTCAATTTAAGGAA
TCTTTTTGCCATGTGTATGCAAATATTATTTTCTTCATACATTCATTTTCTTTTCAGGGGAAAATTTTGGGATGGGGGACTCAGGAGGAC
CTGTGAAGCATGTAGTTATCTAGATCTGGGTAATTTCATGTTTATTAAACTCGAACTTTGGCTAGTTAAACTCATATTGAAACTTCATCT
AGTCTCTTAATTTTTTAACACTAAATTCAAGTCATTTGTTTTAAGTCTCTAAAAAAGAAGATTGCAGTCATCCATTCATATGCATGGGGT
CTGATCGCAAATACACTAAATGTGGAGTGTAGGAACCAAAATGAAACCTGCTGTATGGAAACTACTTTCACTTATGGTTCATTGGTTTTT
GTACCAATATTTTTTATGCACTTCAGTGCAAGTCTTGTCAGTTAACCTTACTTTATGAGTAAGCTAAATAACCCAAATTACATTTCTTTA
AACCTGTTTTACTACTATGGCACTTTGATAAAATGGTCAGGAACCAACTTTACTGGCAAAAGGGTCCATGTACCACCATGTGCTGGAGCA
TCTGTTCTACATGTGGATATCTATGAATGGTAATGTTTTCCTTCATGTAAGTGCCTATTCAGAGTTTCAGAATTTTAAAATGCCAAATAT
TTTCATGGTCATTTGCATGTAGTAAGCCAGAAAATATTCAAAGAGATTTTGAAAACCAATTGTATTTAACCAGCCTCAAATTGTGCAACC

>In-frame_ENST00000373290_ENST00000263559_TCGA-E2-A15S_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915567_length(amino acids)=308AA_start in transcript=122_stop in transcript=1048
MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDF
EFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLL
VRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQ

--------------------------------------------------------------
>In-frame_ENST00000373290_ENST00000395098_TCGA-E2-A15S_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915567_length(transcript)=2493nt_BP=218nt
CGGAGAGAACGCCGGTGGCGGGGCTGGTAGCCCGGCAGCCGCAGGTGGGGCCACGAGCGCTGGCTGAGGGACCGAGCCGGAGAGCCCCGG
AGCCCCCGTAACCCGCGCGGGGAGCGCCCAGGATGCCGCGCGGGGACTCGGAGCAGGTGCGCTACTGCGCGCGCTTCTCCTACCTCTGGC
TCAAGTTTTCACTTATCATCTATTCCACCGTGTTCTGGGTAAACCTAGCCTTTAAGCAACCTGGAAAGAGGCTAGAACACCAAGGAATTA
GAATTGAATTTGTAGGTCAAATTGAACTTTTCAATGACAAGAGTAATACTCATGAATTTGTAAACCTAGTGAAAGAACTAGCCTTACCTG
GAGAACTGACTCAGAGCAGAAGTTATGATTTTGAATTTATGCAAGTTGAAAAGCCATATGAATCTTACATCGGTGCCAATGTCCGCTTGA
GGTATTTTCTTAAAGTGACAATAGTGAGAAGACTGACAGATTTGGTAAAAGAGTATGATCTTATTGTTCACCAGCTTGCCACCTATCCTG
ATGTTAACAACTCTATTAAGATGGAAGTGGGCATTGAAGATTGTCTACATATAGAATTTGAATATAATAAATCAAAGTATCATTTAAAGG
ATGTGATTGTTGGAAAAATTTACTTCTTATTAGTAAGAATAAAAATACAACATATGGAGTTACAGCTGATCAAAAAAGAGATCACAGGAA
TTGGACCCAGTACCACAACAGAAACAGAAACAATCGCCAAATATGAAATAATGGATGGTGCACCAGTAAAAGGAGATAATTTTATGGAGA
AAAGCTCCTGAAAAACTGAGGAAACAGAGAACAAACTTTCACCAGCGATTTGAATCTCCAGAATCACAGGCATCTGCCGAACAGCCTGAA
ATGTGAACTGAACAGGAGAAAAAAAGAAAAGCAAAAAACTCCTGTAACCCTTGAGATTAAGTTCAGCAGGTTAAAGATGGTTGCAGCTGG
AGGGGGCGGAAAAAGGCCAAAACTCCATATATGTTAGTCTTCCTTTATCTTACAGCGCAGCATTTATTTTATGATATAATGAAATGTTCG
TTCATGTATATACATTTTTAAAAGTGCTTTCTTTGAAACACTGGAACTTTGTTAAGCTGCCTTTTTTTTTTTAACTTCCTACTTTGATGA
TAAGCACTCAGATATATATCAGCGTAAACATGAAAAATTTTCATGTGAGTAGGCTGGTATTTGTAATTTTGCTTTCTTTCTGCATAATGT
TGATTATAAATCCTCTCTTTTCAGGCTAATGATTACCTCTTATTCTCTACATGCAAAAAATTAAATATTTTGTGTTCAAATAAAATTAGA
AAACCTGAGTGGCCTCTTGTGTCCTGCAGAGATTTAAAACATGGCATCTCAATATTTTTGAGAACTACATTTGTTTTTAACATATGTGTT
TGAGAAAAGCATATGGAGTGTTTCACCGCAGGCACTTCTGAGTACCATTCCATGGCTTCCAGAATTTTATCCTCTTTGAGGTCTTCTGTG
CTATGAATATTAGATTTCTTTCCCCAAGGGATTATGTGGCAGGTCATTATGGCCTTCTTTTTTTTGGCCATATTAAGTAACAGTTTTGCT
ATATTCCAGTAGTACCGTTGTGTGTTTTCTGCAATGTGGAGTTGACTTAGCTTGGCATTTTAGATTTGTTAAAACTATTTTTTCCATAAA
TACTTTGAAACATATTTATATATTTCAATTTAAGGAATCTTTTTGCCATGTGTATGCAAATATTATTTTCTTCATACATTCATTTTCTTT
TCAGGGGAAAATTTTGGGATGGGGGACTCAGGAGGACCTGTGAAGCATGTAGTTATCTAGATCTGGGTAATTTCATGTTTATTAAACTCG
AACTTTGGCTAGTTAAACTCATATTGAAACTTCATCTAGTCTCTTAATTTTTTAACACTAAATTCAAGTCATTTGTTTTAAGTCTCTAAA
AAAGAAGATTGCAGTCATCCATTCATATGCATGGGGTCTGATCGCAAATACACTAAATGTGGAGTGTAGGAACCAAAATGAAACCTGCTG
TATGGAAACTACTTTCACTTATGGTTCATTGGTTTTTGTACCAATATTTTTTATGCACTTCAGTGCAAGTCTTGTCAGTTAACCTTACTT
TATGAGTAAGCTAAATAACCCAAATTACATTTCTTTAAACCTGTTTTACTACTATGGCACTTTGATAAAATGGTCAGGAACCAACTTTAC
TGGCAAAAGGGTCCATGTACCACCATGTGCTGGAGCATCTGTTCTACATGTGGATATCTATGAATGGTAATGTTTTCCTTCATGTAAGTG
CCTATTCAGAGTTTCAGAATTTTAAAATGCCAAATATTTTCATGGTCATTTGCATGTAGTAAGCCAGAAAATATTCAAAGAGATTTTGAA

>In-frame_ENST00000373290_ENST00000395098_TCGA-E2-A15S_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915567_length(amino acids)=232AA_start in transcript=122_stop in transcript=820
MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDF
EFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLL

--------------------------------------------------------------
>In-frame_ENST00000373290_ENST00000546041_TCGA-E2-A15S_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915567_length(transcript)=1305nt_BP=218nt
CGGAGAGAACGCCGGTGGCGGGGCTGGTAGCCCGGCAGCCGCAGGTGGGGCCACGAGCGCTGGCTGAGGGACCGAGCCGGAGAGCCCCGG
AGCCCCCGTAACCCGCGCGGGGAGCGCCCAGGATGCCGCGCGGGGACTCGGAGCAGGTGCGCTACTGCGCGCGCTTCTCCTACCTCTGGC
TCAAGTTTTCACTTATCATCTATTCCACCGTGTTCTGGGTAAACCTAGCCTTTAAGCAACCTGGAAAGAGGCTAGAACACCAAGGAATTA
GAATTGAATTTGTAGGTCAAATTGAACTTTTCAATGACAAGAGTAATACTCATGAATTTGTAAACCTAGTGAAAGAACTAGCCTTACCTG
GAGAACTGACTCAGAGCAGAAGTTATGATTTTGAATTTATGCAAGTTGAAAAGCCATATGAATCTTACATCGGTGCCAATGTCCGCTTGA
GGTATTTTCTTAAAGTGACAATAGTGAGAAGACTGACAGATTTGGTAAAAGAGTATGATCTTATTGTTCACCAGCTTGCCACCTATCCTG
ATGTTAACAACTCTATTAAGATGGAAGTGGGCATTGAAGATTGTCTACATATAGAATTTGAATATAATAAATCAAAGTATCATTTAAAGG
ATGTGATTGTTGGAAAAATTTACTTCTTATTAGTAAGAATAAAAATACAACATATGGAGTTACAGCTGATCAAAAAAGAGATCACAGGAA
TTGGACCCAGTACCACAACAGAAACAGAAACAATCGCCAAATATGAAATAATGGATGGTGCACCAGTAAAAGGTGAATCAATTCCAATAA
GGCTATTTTTAGCAGGATATGACCCAACTCCAACAATGAGAGATGTGAACAAAAAATTTTCAGTAAGGTACTTTTTGAATTTAGTGCTTG
TTGATGAGGAAGACCGGAGGTACTTCAAACAGCAGGAGATAATTTTATGGAGAAAAGCTCCTGAAAAACTGAGGAAACAGAGAACAAACT
TTCACCAGCGATTTGAATCTCCAGAATCACAGGCATCTGCCGAACAGCCTGAAATGTGAACTGAACAGGAGAAAAAAAGAAAAGCAAAAA
ACTCCTGTAACCCTTGAGATTAAGTTCAGCAGGTTAAAGATGGTTGCAGCTGGAGGGGGCGGAAAAAGGCCAAAACTCCATATATGTTAG
TCTTCCTTTATCTTACAGCGCAGCATTTATTTTATGATATAATGAAATGTTCGTTCATGTATATACATTTTTAAAAGTGCTTTCTTTGAA

>In-frame_ENST00000373290_ENST00000546041_TCGA-E2-A15S_TSPAN15_chr10_71211446_+_VPS26A_chr10_70915567_length(amino acids)=308AA_start in transcript=122_stop in transcript=1048
MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDF
EFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLL
VRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TSPAN15-VPS26A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TSPAN15-VPS26A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TSPAN15-VPS26A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneVPS26AC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human