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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TSPAN5-PKD2 (FusionGDB2 ID:94119)

Fusion Gene Summary for TSPAN5-PKD2

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPAN5-PKD2
Fusion gene ID: 94119
HgeneTgene
Gene symbol

TSPAN5

PKD2

Gene ID

10098

25865

Gene nametetraspanin 5protein kinase D2
SynonymsNET-4|NET4|TM4SF9|TSPAN-5HSPC187|PKD2|nPKC-D2
Cytomap

4q23

19q13.32

Type of geneprotein-codingprotein-coding
Descriptiontetraspanin-5tetraspan NET-4tetraspan TM4SFtransmembrane 4 superfamily member 9transmembrane 4 superfamily, member 8serine/threonine-protein kinase D2
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000305798, ENST00000505184, 
ENST00000509168, 		ENST00000237596, 
ENST00000508588, ENST00000511337, 
ENST00000502363, 
Fusion gene scores* DoF score7 X 4 X 6=1684 X 4 X 3=48
# samples 94
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSPAN5 [Title/Abstract] AND PKD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTSPAN5(99579297)-PKD2(88973143), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePKD2

GO:0006468

protein phosphorylation

22228765

TgenePKD2

GO:0018105

peptidyl-serine phosphorylation

18440775

TgenePKD2

GO:0045944

positive regulation of transcription by RNA polymerase II

17077180

TgenePKD2

GO:0046777

protein autophosphorylation

17077180

TgenePKD2

GO:0050852

T cell receptor signaling pathway

17077180


check buttonFusion gene breakpoints across TSPAN5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PKD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A243-01ATSPAN5chr4

99579297

-PKD2chr4

88973143

+


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Fusion Gene ORF analysis for TSPAN5-PKD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000305798ENST00000237596TSPAN5chr4

99579297

-PKD2chr4

88973143

+
5CDS-5UTRENST00000305798ENST00000508588TSPAN5chr4

99579297

-PKD2chr4

88973143

+
5CDS-intronENST00000305798ENST00000511337TSPAN5chr4

99579297

-PKD2chr4

88973143

+
5CDS-intronENST00000305798ENST00000502363TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-3CDSENST00000505184ENST00000237596TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-5UTRENST00000505184ENST00000508588TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-intronENST00000505184ENST00000511337TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-intronENST00000505184ENST00000502363TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-3CDSENST00000509168ENST00000237596TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-5UTRENST00000509168ENST00000508588TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-intronENST00000509168ENST00000511337TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-intronENST00000509168ENST00000502363TSPAN5chr4

99579297

-PKD2chr4

88973143

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000305798TSPAN5chr499579297-ENST00000237596PKD2chr488973143+39264844031842479

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000305798ENST00000237596TSPAN5chr499579297-PKD2chr488973143+0.0003782970.9996216

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Fusion Genomic Features for TSPAN5-PKD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TSPAN5chr499579296-PKD2chr488973142+0.0372609870.96273905
TSPAN5chr499579296-PKD2chr488973142+0.0372609870.96273905

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TSPAN5-PKD2


check button Go to

FGviewer for the breakpoints of chr4:99579297-chr4:88973143

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-181_1727.0269.0Topological domainCytoplasmic
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515763_774516.0969.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0007744
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515833_872516.0969.0Coiled coilOntology_term=ECO:0000269,ECO:0000305
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515750_785516.0969.0DomainEF-hand
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515632_646516.0969.0IntramembranePore-forming
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515641_643516.0969.0MotifSelectivity filter
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515803_822516.0969.0RegionLinker
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515527_552516.0969.0Topological domainExtracellular
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515574_597516.0969.0Topological domainCytoplasmic
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515620_631516.0969.0Topological domainExtracellular
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515647_654516.0969.0Topological domainExtracellular
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515676_968516.0969.0Topological domainCytoplasmic
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515553_573516.0969.0TransmembraneHelical%3B Name%3DS4
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515598_619516.0969.0TransmembraneHelical%3B Name%3D5
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515655_675516.0969.0TransmembraneHelical%3B Name%3DS6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-18114_23227.0269.0Topological domainExtracellular
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-18254_26827.0269.0Topological domainCytoplasmic
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-1839_6127.0269.0Topological domainExtracellular
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-1883_9227.0269.0Topological domainCytoplasmic
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-1818_3827.0269.0TransmembraneHelical
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-18233_25327.0269.0TransmembraneHelical
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-1862_8227.0269.0TransmembraneHelical
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-1893_11327.0269.0TransmembraneHelical
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515153_157516.0969.0Compositional biasNote=Poly-Arg
TgenePKD2chr4:99579297chr4:88973143ENST0000023759651595_107516.0969.0Compositional biasNote=Poly-Glu
TgenePKD2chr4:99579297chr4:88973143ENST000002375965151_219516.0969.0Topological domainCytoplasmic
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515242_468516.0969.0Topological domainExtracellular
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515490_505516.0969.0Topological domainCytoplasmic
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515220_241516.0969.0TransmembraneHelical%3B Name%3DS1
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515469_489516.0969.0TransmembraneHelical%3B Name%3DS2
TgenePKD2chr4:99579297chr4:88973143ENST00000237596515506_526516.0969.0TransmembraneHelical%3B Name%3DS3


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Fusion Gene Sequence for TSPAN5-PKD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000305798_ENST00000237596_TCGA-E9-A243-01A_TSPAN5_chr4_99579297_-_PKD2_chr4_88973143_length(transcript)=3926nt_BP=484nt
GCGAACGGGCGGGCGAGCAAGCGAGCGGCGTCTCCACCAGCATCTGCCGCGGCCGCCTTTGCCCGAAGCCCGGGGACGAACCGACGGACC
GACCGCCTGGCGCACGGACGCGGGCGCTCGCTTTGTGTTCGGGGCTAGCGTCGGCGAGGCTTGAGCTTGCAGCGCGCGGCTTCCCTGCTT
TCTCGCGGCCACCCCGGCTCCGGCGGCCTCGGCGCGCGAGGGGCTGGAGGTGCGGGAGCCGCTCTCCGCCGGTCGGTCCCCGCGCGGCTG
AGCCCAGGCCGCCAGCGCCGCGGCCCCGTGCGGTGTCCCTGAGCTCCTGCTCCCCGCCGGGCTGCTCCGAGCAACGGTGCTTCGGAGCTC
CAAACTCGGGCTGCCGGGGCAAGTGTCTTCATGAACCCAGAGGATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAA
ATACTTCATATTTGGCTTCAATGTCATATTTTGGCTGTCAGTGGTAGCTATAGGAATTAACATATACAGAACATCAAATGTGGAGGTGCT
ACTACAGTTTCTGGAAGATCAAAATACTTTCCCCAACTTTGAGCATCTGGCATATTGGCAGATACAGTTCAACAATATAGCTGCTGTCAC
AGTATTTTTTGTCTGGATTAAGCTCTTCAAATTCATCAATTTTAACAGGACCATGAGCCAGCTCTCGACAACCATGTCTCGATGTGCCAA
AGACCTGTTTGGCTTTGCTATTATGTTCTTCATTATTTTCCTAGCGTATGCTCAGTTGGCATACCTTGTCTTTGGCACTCAGGTCGATGA
CTTCAGTACTTTCCAAGAGTGTATCTTCACTCAATTCCGTATCATTTTGGGCGATATCAACTTTGCAGAGATTGAGGAAGCTAATCGAGT
TTTGGGACCAATTTATTTCACTACATTTGTGTTCTTTATGTTCTTCATTCTTTTGAATATGTTTTTGGCTATCATCAATGATACTTACTC
TGAAGTGAAATCTGACTTGGCACAGCAGAAAGCTGAAATGGAACTCTCAGATCTTATCAGAAAGGGCTACCATAAAGCTTTGGTCAAACT
AAAACTGAAAAAAAATACCGTGGATGACATTTCAGAGAGTCTGCGGCAAGGAGGAGGCAAGTTAAACTTTGACGAACTTCGACAAGATCT
CAAAGGGAAGGGCCATACTGATGCAGAGATTGAGGCAATATTCACAAAGTACGACCAAGATGGAGACCAAGAACTGACCGAACATGAACA
TCAGCAGATGAGAGACGACTTGGAGAAAGAGAGGGAGGACCTGGATTTGGATCACAGTTCTTTACCACGTCCCATGAGCAGCCGAAGTTT
CCCTCGAAGCCTGGATGACTCTGAGGAGGATGACGATGAAGATAGCGGACATAGCTCCAGAAGGAGGGGAAGCATTTCTAGTGGCGTTTC
TTACGAAGAGTTTCAAGTCCTGGTGAGACGAGTGGACCGGATGGAGCATTCCATCGGCAGCATAGTGTCCAAGATTGACGCCGTGATCGT
GAAGCTAGAGATTATGGAGCGAGCCAAACTGAAGAGGAGGGAGGTGCTGGGAAGGCTGTTGGATGGGGTGGCCGAGGATGAAAGGCTGGG
TCGTGACAGTGAAATCCATAGGGAACAGATGGAACGGCTAGTACGTGAAGAGTTGGAACGCTGGGAATCCGATGATGCAGCTTCCCAGAT
CAGTCATGGTTTAGGCACGCCAGTGGGACTAAATGGTCAACCTCGCCCCAGAAGCTCCCGCCCATCTTCCTCCCAATCTACAGAAGGCAT
GGAAGGTGCAGGTGGAAATGGGAGTTCTAATGTCCACGTATGATATGTGTGTTTCAGTATGTGTGTTTCTAATAAGTGAGGAAGTGGCTG
TCCTGAATTGCTGTAACAAGCACACTATTTATATGCCCTGACCACCATAGGATGCTAGTCTTTGTGACCGATTGCTAATCTTCTGCACTT
TAATTTATTTTATATAAACTTTACCCATGGTTCAAAGATTTTTTTTTCTTTTTCTCATATAAGAAATCTAGGTGTAAATATTGAGTACAG
AAAAAAAATCTTCATGATGTGTATTGAGCGGTACGCCCAGTTGCCACCATGACTGAGTCTTCTCAGTTGACAATGAAGTAGCCTTTTAAA
GCTAGAAAACTGTCAAAGGGCTTCTGAGTTTCATTTCCAGTCACAAAAATCAGTATTGTTATTTTTTTCCAAGAGTGTGAAGGAAAATGG
GGCATTCCTTTCCACTCTGGCATAGTTCATGAGCTTAATACATAGCTTTCTTTTAAGAAAGGAGCCTTTTTTTTCAACTAGCTTCCTGGG
GTAAACTTTTCTAAAAGATAAAATGGAAAGGAACTCCAAACTATGATAGAATCTGTGTGAATGGTTAAGATGAATGTTAAATACTATGCT
TTTTTGTAAGTTGATCGTATCTGATGTCTGTGGGACTAACTGTATCACTTAATTTTTACCTTATTTTGGCTCTAATTTGAATAAGCTGAG
TAAAACCACCAAAGATCAGTTATAGGATAAAATGGCATCTCTAACCATAACACAGGAGAATTGGAAGGAGCCCTAAGTTGTCACTCAGTT
TAATTTCTTTTAATGGTTAGTTTAGCCTAAAGATTTATCTGCATATTCTTTTTCCCATGTGGCTCTACTCATTTGCAACTGAATTTAATG
TTATAACTCATCTAGTGAGACCAACTTACTAAATTTTTAGTATGCACTGAAAGTTTTTATCCAACAATTATGTTCATTTTAAGCAAAATT
TTAAGAAAGTTTTGAAATTCATAAAGCATTTGGTTTTAAACTATTTTAAGAATATAGTACTCGGTCAGGTATGACGGCTCACGCCTGTAA
TCCCAGCACTTTGGGAGGCCGAAACAGGCGAATCACTTGAGCCCAGGAGTTCAAGACCAACATGGGCAATGTGGCGAAACTCCATCTCTA
CAAAAAATGCAAAAATAAAAAATATAGTACTCAAGTATTCTTGATCCTGTGTTTCAAAACTAGAATTTGTAATGCAAATGGAGCTCAGTC
TAATAAAAAAGAGGTTTTGGTATTAAAAGTTCATACATTAGACAGTATCAGCCAAAATTTGAGTTAGCAACACTGTTTTCTTTACGAGAG
GGTCTCACCCAAATTTATGGGGAGAAATCTATTTCTCAAAAAAAAAAATCTTCTTTTACAGAAATGTTGAGTAAGGTGACATTTTGAGCG
CTAATAAGCAAAAGAGCATGCAGTGCTGTTGAATAACCCTCACTTGGAGAACCAAGAGAATCCTGTCGTTTAATGCTATATTTTAATTTC
ACAAGTTGTTCATTTAACTGGTAGAATGTCAGTCCAATCTCCAATGAGAACATGAGCAAATAGACCTTTCCAGGTTGAAAGTGAAACATA
CTGGGTTTCTGTAAGTTTTTCCTCATGGCTTCATCTCTATCTTTACTTTCTCTTGAATATGCTACACAAAGTTCTTTATTACTACATACT
AAAGTTTGCATTCCAGGGATATTGACTGTACATATTTATGTATATGTACCATGTTGTTACATGTAAACAAACTTCAATTTGAAGTGCAGC
TATTATGTGGTATCCATGTGTATCGACCATGTGCCATATATCAATTATGGTCACTAGAAAGTCTCTTTATGATACTTTTTATTGTACTGT
TTTTCATTTCACTTGCAAAATTTTGCAGAATTCCTCCTTTCTACCCATAAATTACATATATTTTTCTTCTTTAGTCATGGAGAACTCCCC
CCCTCATCTCTTCCCTATTATCTTTCCCTGTGTACTGGTATTATTAAAAAGACATTACATACGCAAGTCTTTCTCGACAATCAAGAATGT

>In-frame_ENST00000305798_ENST00000237596_TCGA-E9-A243-01A_TSPAN5_chr4_99579297_-_PKD2_chr4_88973143_length(amino acids)=479AA_start in transcript=403_stop in transcript=1842
MSGKHYKGPEVSCCIKYFIFGFNVIFWLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINF
NRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMF
FILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIF
TKYDQDGDQELTEHEHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRM
EHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMERLVREELERWESDDAASQISHGLGTPVGLNGQP

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Fusion Gene PPI Analysis for TSPAN5-PKD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TSPAN5-PKD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TSPAN5-PKD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePKD2C2751306Polycystic kidney disease, type 223CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePKD2C0085413Polycystic Kidney, Autosomal Dominant20CLINGEN;CTD_human;GENOMICS_ENGLAND
TgenePKD2C0022680Polycystic Kidney Diseases12CLINGEN
TgenePKD2C0887850Polycystic Kidney, Type 1 Autosomal Dominant Disease6CTD_human
TgenePKD2C0023893Liver Cirrhosis, Experimental1CTD_human
TgenePKD2C0035309Retinal Diseases1CTD_human
TgenePKD2C0042373Vascular Diseases1CTD_human
TgenePKD2C0270715Degenerative Diseases, Central Nervous System1CTD_human
TgenePKD2C0524851Neurodegenerative Disorders1CTD_human
TgenePKD2C0751733Degenerative Diseases, Spinal Cord1CTD_human