FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TSPO-PRR5 (FusionGDB2 ID:94166)

Fusion Gene Summary for TSPO-PRR5

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPO-PRR5
Fusion gene ID: 94166
HgeneTgene
Gene symbol

TSPO

PRR5

Gene ID

706

55615

Gene nametranslocator proteinproline rich 5
SynonymsBPBS|BZRP|DBI|IBP|MBR|PBR|PBS|PKBS|PTBR|mDRC|pk18FLJ20185k|PP610|PROTOR-1|PROTOR1
Cytomap

22q13.2

22q13.31

Type of geneprotein-codingprotein-coding
Descriptiontranslocator proteinbenzodiazepine peripheral binding sitemitochondrial benzodiazepine receptorperipheral-type benzodiazepine receptorproline-rich protein 5Rho GTPase activating protein 8proline rich 5 (renal)protein observed with Rictor-1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000337554, ENST00000396265, 
ENST00000583777, ENST00000329563, 
ENST00000006251, ENST00000403581, 
ENST00000336985, ENST00000477331, 
Fusion gene scores* DoF score8 X 5 X 5=2003 X 5 X 3=45
# samples 95
** MAII scorelog2(9/200*10)=-1.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TSPO [Title/Abstract] AND PRR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTSPO(43547610)-PRR5(45121123), # samples:1
TSPO(43547610)-PRR5(45121124), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TSPO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PRR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-AAMWTSPOchr22

43547610

+PRR5chr22

45121123

+
ChimerDB4BLCATCGA-XF-AAMW-01ATSPOchr22

43547610

-PRR5chr22

45121124

+


Top

Fusion Gene ORF analysis for TSPO-PRR5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000337554ENST00000006251TSPOchr22

43547610

+PRR5chr22

45121123

+
5UTR-3CDSENST00000337554ENST00000403581TSPOchr22

43547610

+PRR5chr22

45121123

+
5UTR-3CDSENST00000337554ENST00000336985TSPOchr22

43547610

+PRR5chr22

45121123

+
5UTR-intronENST00000337554ENST00000477331TSPOchr22

43547610

+PRR5chr22

45121123

+
5UTR-3CDSENST00000396265ENST00000006251TSPOchr22

43547610

+PRR5chr22

45121123

+
5UTR-3CDSENST00000396265ENST00000403581TSPOchr22

43547610

+PRR5chr22

45121123

+
5UTR-3CDSENST00000396265ENST00000336985TSPOchr22

43547610

+PRR5chr22

45121123

+
5UTR-intronENST00000396265ENST00000477331TSPOchr22

43547610

+PRR5chr22

45121123

+
5UTR-3CDSENST00000583777ENST00000006251TSPOchr22

43547610

+PRR5chr22

45121123

+
5UTR-3CDSENST00000583777ENST00000403581TSPOchr22

43547610

+PRR5chr22

45121123

+
5UTR-3CDSENST00000583777ENST00000336985TSPOchr22

43547610

+PRR5chr22

45121123

+
5UTR-intronENST00000583777ENST00000477331TSPOchr22

43547610

+PRR5chr22

45121123

+
intron-3CDSENST00000329563ENST00000006251TSPOchr22

43547610

+PRR5chr22

45121123

+
intron-3CDSENST00000329563ENST00000403581TSPOchr22

43547610

+PRR5chr22

45121123

+
intron-3CDSENST00000329563ENST00000336985TSPOchr22

43547610

+PRR5chr22

45121123

+
intron-intronENST00000329563ENST00000477331TSPOchr22

43547610

+PRR5chr22

45121123

+
5UTR-3CDSENST00000337554ENST00000006251TSPOchr22

43547610

-PRR5chr22

45121124

+
5UTR-3CDSENST00000337554ENST00000403581TSPOchr22

43547610

-PRR5chr22

45121124

+
5UTR-3CDSENST00000337554ENST00000336985TSPOchr22

43547610

-PRR5chr22

45121124

+
5UTR-intronENST00000337554ENST00000477331TSPOchr22

43547610

-PRR5chr22

45121124

+
5UTR-3CDSENST00000396265ENST00000006251TSPOchr22

43547610

-PRR5chr22

45121124

+
5UTR-3CDSENST00000396265ENST00000403581TSPOchr22

43547610

-PRR5chr22

45121124

+
5UTR-3CDSENST00000396265ENST00000336985TSPOchr22

43547610

-PRR5chr22

45121124

+
5UTR-intronENST00000396265ENST00000477331TSPOchr22

43547610

-PRR5chr22

45121124

+
5UTR-3CDSENST00000583777ENST00000006251TSPOchr22

43547610

-PRR5chr22

45121124

+
5UTR-3CDSENST00000583777ENST00000403581TSPOchr22

43547610

-PRR5chr22

45121124

+
5UTR-3CDSENST00000583777ENST00000336985TSPOchr22

43547610

-PRR5chr22

45121124

+
5UTR-intronENST00000583777ENST00000477331TSPOchr22

43547610

-PRR5chr22

45121124

+
intron-3CDSENST00000329563ENST00000006251TSPOchr22

43547610

-PRR5chr22

45121124

+
intron-3CDSENST00000329563ENST00000403581TSPOchr22

43547610

-PRR5chr22

45121124

+
intron-3CDSENST00000329563ENST00000336985TSPOchr22

43547610

-PRR5chr22

45121124

+
intron-intronENST00000329563ENST00000477331TSPOchr22

43547610

-PRR5chr22

45121124

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for TSPO-PRR5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TSPOchr2243547610+PRR5chr2245121123+5.43E-060.9999945
TSPOchr2243547610+PRR5chr2245121123+5.43E-060.9999945

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TSPO-PRR5


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for TSPO-PRR5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for TSPO-PRR5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TSPO-PRR5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TSPO-PRR5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTSPOC0019147Hepatic Coma2CTD_human
HgeneTSPOC0019151Hepatic Encephalopathy2CTD_human
HgeneTSPOC0751197Fulminant Hepatic Failure with Cerebral Edema2CTD_human
HgeneTSPOC0751198Hepatic Stupor2CTD_human
HgeneTSPOC0005586Bipolar Disorder1PSYGENET
HgeneTSPOC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTSPOC0745744End Stage Liver Disease1CTD_human
HgeneTSPOC2936476Chronic Liver Failure1CTD_human