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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTC17-TMPRSS4 (FusionGDB2 ID:94263)

Fusion Gene Summary for TTC17-TMPRSS4

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC17-TMPRSS4
Fusion gene ID: 94263
HgeneTgene
Gene symbol

TTC17

TMPRSS4

Gene ID

55761

56649

Gene nametetratricopeptide repeat domain 17transmembrane serine protease 4
Synonyms-CAPH2|MT-SP2|TMPRSS3
Cytomap

11p12-p11.2

11q23.3

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 17TPR repeat protein 17transmembrane protease serine 4channel-activating protease 2membrane-type serine protease 2transmembrane protease, serine 4transmembrane serine protease 3type II membrane serine protease
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000299240, ENST00000039989, 
ENST00000526774, 		ENST00000534111, 
ENST00000522307, ENST00000523251, 
ENST00000437212, ENST00000522824, 
ENST00000518413, 
Fusion gene scores* DoF score8 X 7 X 4=2243 X 3 X 2=18
# samples 83
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TTC17 [Title/Abstract] AND TMPRSS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTC17(43411371)-TMPRSS4(117983984), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTMPRSS4

GO:0010468

regulation of gene expression

29529050

TgeneTMPRSS4

GO:0045967

negative regulation of growth rate

29529050


check buttonFusion gene breakpoints across TTC17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TMPRSS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-2J-AABP-01ATTC17chr11

43411371

-TMPRSS4chr11

117983984

+


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Fusion Gene ORF analysis for TTC17-TMPRSS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000299240ENST00000534111TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
In-frameENST00000299240ENST00000522307TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
In-frameENST00000299240ENST00000523251TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
In-frameENST00000299240ENST00000437212TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
In-frameENST00000299240ENST00000522824TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
5CDS-3UTRENST00000299240ENST00000518413TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
In-frameENST00000039989ENST00000534111TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
In-frameENST00000039989ENST00000522307TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
In-frameENST00000039989ENST00000523251TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
In-frameENST00000039989ENST00000437212TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
In-frameENST00000039989ENST00000522824TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
5CDS-3UTRENST00000039989ENST00000518413TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
intron-3CDSENST00000526774ENST00000534111TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
intron-3CDSENST00000526774ENST00000522307TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
intron-3CDSENST00000526774ENST00000523251TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
intron-3CDSENST00000526774ENST00000437212TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
intron-3CDSENST00000526774ENST00000522824TTC17chr11

43411371

-TMPRSS4chr11

117983984

+
intron-3UTRENST00000526774ENST00000518413TTC17chr11

43411371

-TMPRSS4chr11

117983984

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000299240TTC17chr1143411371-ENST00000534111TMPRSS4chr11117983984+4990442231012329
ENST00000299240TTC17chr1143411371-ENST00000522307TMPRSS4chr11117983984+1191442231012329
ENST00000299240TTC17chr1143411371-ENST00000523251TMPRSS4chr11117983984+1282442231012329
ENST00000299240TTC17chr1143411371-ENST00000437212TMPRSS4chr11117983984+1559442231012329
ENST00000299240TTC17chr1143411371-ENST00000522824TMPRSS4chr11117983984+1557442231012329
ENST00000039989TTC17chr1143411371-ENST00000534111TMPRSS4chr11117983984+4981433141003329
ENST00000039989TTC17chr1143411371-ENST00000522307TMPRSS4chr11117983984+1182433141003329
ENST00000039989TTC17chr1143411371-ENST00000523251TMPRSS4chr11117983984+1273433141003329
ENST00000039989TTC17chr1143411371-ENST00000437212TMPRSS4chr11117983984+1550433141003329
ENST00000039989TTC17chr1143411371-ENST00000522824TMPRSS4chr11117983984+1548433141003329

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000299240ENST00000534111TTC17chr1143411371-TMPRSS4chr11117983984+0.0020297110.9979703
ENST00000299240ENST00000522307TTC17chr1143411371-TMPRSS4chr11117983984+0.0047109050.9952891
ENST00000299240ENST00000523251TTC17chr1143411371-TMPRSS4chr11117983984+0.0060056480.9939944
ENST00000299240ENST00000437212TTC17chr1143411371-TMPRSS4chr11117983984+0.007308460.9926916
ENST00000299240ENST00000522824TTC17chr1143411371-TMPRSS4chr11117983984+0.0073269560.992673
ENST00000039989ENST00000534111TTC17chr1143411371-TMPRSS4chr11117983984+0.0020293140.99797064
ENST00000039989ENST00000522307TTC17chr1143411371-TMPRSS4chr11117983984+0.0047833310.9952167
ENST00000039989ENST00000523251TTC17chr1143411371-TMPRSS4chr11117983984+0.0060929690.99390703
ENST00000039989ENST00000437212TTC17chr1143411371-TMPRSS4chr11117983984+0.0074499040.99255013
ENST00000039989ENST00000522824TTC17chr1143411371-TMPRSS4chr11117983984+0.0074777390.9925223

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Fusion Genomic Features for TTC17-TMPRSS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TTC17-TMPRSS4


check button Go to

FGviewer for the breakpoints of chr11:43411371-chr11:117983984

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC17chr11:43411371chr11:117983984ENST00000039989-324340_382139.666666666666661142.0Coiled coilOntology_term=ECO:0000255
HgeneTTC17chr11:43411371chr11:117983984ENST00000039989-3241014_1048139.666666666666661142.0RepeatNote=TPR 4
HgeneTTC17chr11:43411371chr11:117983984ENST00000039989-3241051_1084139.666666666666661142.0RepeatNote=TPR 5
HgeneTTC17chr11:43411371chr11:117983984ENST00000039989-3241085_1118139.666666666666661142.0RepeatNote=TPR 6
HgeneTTC17chr11:43411371chr11:117983984ENST00000039989-324295_328139.666666666666661142.0RepeatNote=TPR 1
HgeneTTC17chr11:43411371chr11:117983984ENST00000039989-324619_652139.666666666666661142.0RepeatNote=TPR 2
HgeneTTC17chr11:43411371chr11:117983984ENST00000039989-324689_722139.666666666666661142.0RepeatNote=TPR 3
TgeneTMPRSS4chr11:43411371chr11:117983984ENST00000437212713205_434247.66666666666666438.0DomainPeptidase S1
TgeneTMPRSS4chr11:43411371chr11:117983984ENST0000043721271361_93247.66666666666666438.0DomainNote=LDL-receptor class A
TgeneTMPRSS4chr11:43411371chr11:117983984ENST0000043721271394_204247.66666666666666438.0DomainSRCR
TgeneTMPRSS4chr11:43411371chr11:117983984ENST00000522824713205_434242.66666666666666433.0DomainPeptidase S1
TgeneTMPRSS4chr11:43411371chr11:117983984ENST0000052282471361_93242.66666666666666433.0DomainNote=LDL-receptor class A
TgeneTMPRSS4chr11:43411371chr11:117983984ENST0000052282471394_204242.66666666666666433.0DomainSRCR
TgeneTMPRSS4chr11:43411371chr11:117983984ENST00000534111713205_434245.66666666666666436.0DomainPeptidase S1
TgeneTMPRSS4chr11:43411371chr11:117983984ENST0000053411171361_93245.66666666666666436.0DomainNote=LDL-receptor class A
TgeneTMPRSS4chr11:43411371chr11:117983984ENST0000053411171394_204245.66666666666666436.0DomainSRCR
TgeneTMPRSS4chr11:43411371chr11:117983984ENST000004372127131_32247.66666666666666438.0Topological domainCytoplasmic
TgeneTMPRSS4chr11:43411371chr11:117983984ENST0000043721271354_437247.66666666666666438.0Topological domainExtracellular
TgeneTMPRSS4chr11:43411371chr11:117983984ENST000005228247131_32242.66666666666666433.0Topological domainCytoplasmic
TgeneTMPRSS4chr11:43411371chr11:117983984ENST0000052282471354_437242.66666666666666433.0Topological domainExtracellular
TgeneTMPRSS4chr11:43411371chr11:117983984ENST000005341117131_32245.66666666666666436.0Topological domainCytoplasmic
TgeneTMPRSS4chr11:43411371chr11:117983984ENST0000053411171354_437245.66666666666666436.0Topological domainExtracellular
TgeneTMPRSS4chr11:43411371chr11:117983984ENST0000043721271333_53247.66666666666666438.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS4chr11:43411371chr11:117983984ENST0000052282471333_53242.66666666666666433.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS4chr11:43411371chr11:117983984ENST0000053411171333_53245.66666666666666436.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for TTC17-TMPRSS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000299240_ENST00000534111_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(transcript)=4990nt_BP=442nt
AGCGGCCCGGCCGGGGGGGCAAGATGGCGGCGGCAGTAGGGGTTCGTGGCCGGTACGAGCTGCCGCCTTGCTCCGGCCCAGGCTGGCTCC
TCAGCCTTTCCGCCTTGCTGAGTGTGGCGGCACGAGGGGCCTTCGCCACCACGCACTGGGTCGTCACGGAGGACGGGAAAATCCAGCAGC
AGGTGGATTCACCAATGAACTTGAAGCATCCTCATGACCTAGTCATATTAATGAGACAAGAAGCAACAGTTAACTACCTCAAAGAATTAG
AGAAACAATTAGTTGCTCAAAAAATTCACATAGAAGAGAATGAGGACAGAGACACAGGACTGGAACAGAGACATAATAAAGAAGACCCAG
ACTGCATCAAAGCCAAGGTGCCCTTAGGGGACCTGGATCTATATGATGGCACATACATAACTTTGGAGAGCAAAGACATCAGGAAACATA
CCGATGTGTTCAACTGGAAGGTGCGGGCAGGCTCAGACAAACTGGGCAGCTTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAAT
TCAACCCCATGTACCCCAAAGACAATGACATCGCCCTCATGAAGCTGCAGTTCCCACTCACTTTCTCAGGCACAGTCAGGCCCATCTGTC
TGCCCTTCTTTGATGAGGAGCTCACTCCAGCCACCCCACTCTGGATCATTGGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTG
ACATACTGCTGCAGGCGTCAGTCCAGGTCATTGACAGCACACGGTGCAATGCAGACGATGCGTACCAGGGGGAAGTCACCGAGAAGATGA
TGTGTGCAGGCATCCCGGAAGGGGGTGTGGACACCTGCCAGGGTGACAGTGGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGG
TGGGCATCGTTAGTTGGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGAGTATACACCAAGGTCTCAGCCTATCTCAACTGGATCTACA
ATGTCTGGAAGGCTGAGCTGTAATGCTGCTGCCCCTTTGCAGTGCTGGGAGCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAA
AGTCAGACACAGAGCAAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGCCTCAGCATTTCTTGGAGCAGCAAAGGGCCTCAATTCCTAT
AAGAGACCCTCGCAGCCCAGAGGCGCCCAGAGGAAGTCAGCAGCCCTAGCTCGGCCACACTTGGTGCTCCCAGCATCCCAGGGAGAGACA
CAGCCCACTGAACAAGGTCTCAGGGGTATTGCTAAGCCAAGAAGGAACTTTCCCACACTACTGAATGGAAGCAGGCTGTCTTGTAAAAGC
CCAGATCACTGTGGGCTGGAGAGGAGAAGGAAAGGGTCTGCGCCAGCCCTGTCCGTCTTCACCCATCCCCAAGCCTACTAGAGCAAGAAA
CCAGTTGTAATATAAAATGCACTGCCCTACTGTTGGTATGACTACCGTTACCTACTGTTGTCATTGTTATTACAGCTATGGCCACTATTA
TTAAAGAGCTGTGTAACATCTCTGGCATAGGCTAGCTGGAATGCTTGATAAGAACTGAGCTGGGATGATTGAACTTTCATTCTTTGGCTT
GGGGAGAAAAGAAGTCCTGGGGAAGCAATTGAGTCTCAAAGTAGAGGCAGGGGAAAAAAGAGTTAGGGAGACCAGATCTGCTGAGTGGCA
GCAAGAGTGAGCTGCAGATTACAGAAACCAGGGTGAGCAAGTTTGAGTCCCACACAGGGCCTTCTCCCTTTGCCTCTTTCCCTCCCTCCC
TGCCTGTGATAATCAGCCAGGAGCCAGGGATAACCTATGACTTGGGAAAGAGATGAGTTAGGCAGTCAAGGGTGACATTCAATCAGGGAT
CCACAAGTGGCTGGAAAGAAATGCTGGTCCTGTGTCCTAACTTTTTCCGCCTGGAGAGCCCTCAGTGTGGCTTCTTACATTTAAAAAACA
AAAAGGATCAGCTGCCAGGTGTGAGGCAGTCCCCAAGCTGAGTTGTGAGGATGTAAGCATGAATAAGTCCCTGCACTCAAAATGGTCAAA
GAATTAAACCCCATGGACTTTTTTGGCATCTGTATGAAAGCTTGGGTTTTCTGAGGACTGTCTTGCTATAGTTAAGTCAGATCCTAGATG
AAATATACTTGTTCATACTGTACTAGGTTCTTAGGAAACAACAGAATTCCTCAAATGCCAAAAACAAAGAAAATAGAAACCCAGAAAACA
AAACAAAATAAAACAAAACCATCAGAACTGTGAGTGGAAACTAAGGTGATGATCTGGGAGCAATACACTAAAATCTTGGGTCGAGACCTA
TATGAAGGCTGGCAGTGGAGCTAAACCTGGACACACTGAAGACAAGGGAGCTGAACCAGGGCTCCTACATGAAGCAGGGATAACTGATGG
CAGTAAATGTGGTCTCAAATTGCAGATGGTCTGGAGGAAAATTTCCCAAATTTAGAGCCTCAGGATTCCCAAAGATCCTCCAAATATGAG
CTCACAATCAAAGATCAGAGACGTTGAAAAATAAAAAACACCTTAAGTGGGCAGCATAAAAAACAGCTAATTTAGAACCCCAAAGGCTTC
AGATGTCAGAATATTAGAGACTTATGATAATAAGCAATATTTGCAGAGTATTTGTATGTGCCAGACACTATTGTAAGTGCTTCATCATGT
ACTGATTCATTTAATACTCACAGAAATCTGTGAGATGGGTATTATTCTTATCCTCACTCTATGGATTAAAAAAACTAAGGCACAAAGTGG
TTAAGCTCCTTGCCTGAGATTATAGACTGTAAGTTGAACGTGAGCACTTGGAATACAGAGTTCATGCTGTAAACTACCACACTATAGGGC
CTCCAATATGATAATTTATAAAATATTTGAATAAAAAATGAATACTAGTTCCACATTTTAAAATCATGTTTAACTGTGGTCAAATGCACA
TAACACAAGTTGCCATCTTCACCATTTTTAGGTGTATAGTTCAGTGGTGTTATGTACATTCACACTATTGTGCAGTCATCACCACCATCC
ATCTCCAGAACAGAAACTCAGTACCCATCAAACAACTCTCCATTTCCCCCTCCTCCCAATCTCTGGCAACCACCATTGTGCTTTCAGTCT
CTGTGAACTGGATTACTCTGGGTACCTCATTTAAGTGAAGTCATGCAGTATTGGTCTTTTTGTACTTGTTTTATTTCACTTCACATTGTG
TCTTCAAGTTTCACCCATGTTGTAGCATGTGTCAGAATTTCTTCCCTTTTTAGACTAAATAATATTCTATTGTTTATACGAACATTCAGG
TTACTTCTATCTTTTGGCTATTGTGAATTATGCTGCTGTGAACATGGGTGTACAAGTATCTCTTTGAGGCCCTGCTTTCAATTCTCTTGG
GTATATTCCCAGAAGTGGAATTGCTGGATCATATGGTAATTCTATTTTGAATTTTTTGAGGAACTGATATATTGCTTTCCATAGAGACTG
CACCATTTTACATTCCCATCAACAGTTTGCAGGAGTTACTATTTCTCCATATCCCCCCTAACACTTGCTATTTTCTGTTAAAAATGGATA
TCTTAATAATCAAGCAAAAATAACAGGCAGATTTGAAAAAGAACTGAATACAGCTTTTAGAAATAAAAACTATAATTATAAAAATAAAAA
ACTAAGTGGATGGGGTAAATAACAATTAAAACACCAATTAAGAGAGAACAAATGAACTGGAAGATAAATTGAAGAAGTGACTAGGCTTAA
CAGCAGAGAGAGATAAGGAGATTAAAAATATGAAAACAAGGCCAGGAGCAATGAAGCCTAGAATGGTAAATTCTAACATATCCAGAATCC
CAGAAAGAGAGAATCAAGACAATGAGAGAGAGACAGTACCAAAGAGATAAGAGCTGAGAATGTTCCAGAATTGATAAAAGGTGTGAATCC
ACAGAACATACACCACCATAGTGTACACGCATACAACCAAGGTGGAAAAATTAGAATAAATCCACACCTATGTACATTATAATGAAACTG
CAGAACACCAAAGACAAAAAGAAACTCCTTATAGCAGCAGAGAGAAAACCCAGACCACCCACAGTACCACAAATCTACCACAATTAGACT
GACAACAGGCTTTCCCACAGCAATAAAGGAGCTAGAAGTCAGTGGAAGTATATCTCCAGCATGCCAAAAGATAACAATCAATCAGGGATT
GTGAACCCTACAAAACTATCTTTCAAGAATAAAGGCATTTTCAAGAAAACAAAAACAGACTTTACCATCAACAAACCTTCTCTAAAAGAA
TATATAAAGCATTTACTTTAGGAAGAAGGAAAATGATCCTAAAAGGAAGAACCAAGAAGCAAGTAGCAATAGTGAGGCAATTGTGAAAAT
GTAGGTAAGTCTAAACACACTCTGTCTACTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTATTTTGAGACTGAGTCTTGCCCTGTCACC
CAGACTGGAGTGCAGTGGCAGGATCTTGGCTCACTGCTATCTCCACCTCCCAGGTTCAAGTGATTCTTCTGCCTCAGCCTCCCGAGTAGC
TGGGATTACATGCACATGCCACCATATCCGGCTAATTTTTGAATTTTTAGTAGAGATGGGGTTTCACTGTGTTGGCCAGGCCGGTCTCAA
ACTCCCGACCTCAAGTGATCCCCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGTCTACATATTATTAAAATAACAATAATAT
TTATTTTGTGGGTTAATTTTTTTTGAAACAGATATTGAATTTATTGGTTGGCTATGAGTAGAAAAATACATCAGTAAAGAAAAAAGACCC
TGTATATAAATATAATACTAGCTAGTTAAAATTTGACCAAGAAGTTTCCATTGTGGGTTAATTTTTAAAGGCCTAACTGAAATATGGAGT

>In-frame_ENST00000299240_ENST00000534111_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(amino acids)=329AA_start in transcript=23_stop in transcript=1012
MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQEATVNYLKELEKQLVAQK
IHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDIRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKD
NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEG

--------------------------------------------------------------
>In-frame_ENST00000299240_ENST00000522307_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(transcript)=1191nt_BP=442nt
AGCGGCCCGGCCGGGGGGGCAAGATGGCGGCGGCAGTAGGGGTTCGTGGCCGGTACGAGCTGCCGCCTTGCTCCGGCCCAGGCTGGCTCC
TCAGCCTTTCCGCCTTGCTGAGTGTGGCGGCACGAGGGGCCTTCGCCACCACGCACTGGGTCGTCACGGAGGACGGGAAAATCCAGCAGC
AGGTGGATTCACCAATGAACTTGAAGCATCCTCATGACCTAGTCATATTAATGAGACAAGAAGCAACAGTTAACTACCTCAAAGAATTAG
AGAAACAATTAGTTGCTCAAAAAATTCACATAGAAGAGAATGAGGACAGAGACACAGGACTGGAACAGAGACATAATAAAGAAGACCCAG
ACTGCATCAAAGCCAAGGTGCCCTTAGGGGACCTGGATCTATATGATGGCACATACATAACTTTGGAGAGCAAAGACATCAGGAAACATA
CCGATGTGTTCAACTGGAAGGTGCGGGCAGGCTCAGACAAACTGGGCAGCTTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAAT
TCAACCCCATGTACCCCAAAGACAATGACATCGCCCTCATGAAGCTGCAGTTCCCACTCACTTTCTCAGGCACAGTCAGGCCCATCTGTC
TGCCCTTCTTTGATGAGGAGCTCACTCCAGCCACCCCACTCTGGATCATTGGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTG
ACATACTGCTGCAGGCGTCAGTCCAGGTCATTGACAGCACACGGTGCAATGCAGACGATGCGTACCAGGGGGAAGTCACCGAGAAGATGA
TGTGTGCAGGCATCCCGGAAGGGGGTGTGGACACCTGCCAGGGTGACAGTGGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGG
TGGGCATCGTTAGTTGGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGAGTATACACCAAGGTCTCAGCCTATCTCAACTGGATCTACA
ATGTCTGGAAGGCTGAGCTGTAATGCTGCTGCCCCTTTGCAGTGCTGGGAGCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAA
AGTCAGACACAGAGCAAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGCCTCAGCATTTCTTGGAGCAGCAAAGGGCCTCAATTCCTAT

>In-frame_ENST00000299240_ENST00000522307_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(amino acids)=329AA_start in transcript=23_stop in transcript=1012
MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQEATVNYLKELEKQLVAQK
IHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDIRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKD
NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEG

--------------------------------------------------------------
>In-frame_ENST00000299240_ENST00000523251_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(transcript)=1282nt_BP=442nt
AGCGGCCCGGCCGGGGGGGCAAGATGGCGGCGGCAGTAGGGGTTCGTGGCCGGTACGAGCTGCCGCCTTGCTCCGGCCCAGGCTGGCTCC
TCAGCCTTTCCGCCTTGCTGAGTGTGGCGGCACGAGGGGCCTTCGCCACCACGCACTGGGTCGTCACGGAGGACGGGAAAATCCAGCAGC
AGGTGGATTCACCAATGAACTTGAAGCATCCTCATGACCTAGTCATATTAATGAGACAAGAAGCAACAGTTAACTACCTCAAAGAATTAG
AGAAACAATTAGTTGCTCAAAAAATTCACATAGAAGAGAATGAGGACAGAGACACAGGACTGGAACAGAGACATAATAAAGAAGACCCAG
ACTGCATCAAAGCCAAGGTGCCCTTAGGGGACCTGGATCTATATGATGGCACATACATAACTTTGGAGAGCAAAGACATCAGGAAACATA
CCGATGTGTTCAACTGGAAGGTGCGGGCAGGCTCAGACAAACTGGGCAGCTTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAAT
TCAACCCCATGTACCCCAAAGACAATGACATCGCCCTCATGAAGCTGCAGTTCCCACTCACTTTCTCAGGCACAGTCAGGCCCATCTGTC
TGCCCTTCTTTGATGAGGAGCTCACTCCAGCCACCCCACTCTGGATCATTGGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTG
ACATACTGCTGCAGGCGTCAGTCCAGGTCATTGACAGCACACGGTGCAATGCAGACGATGCGTACCAGGGGGAAGTCACCGAGAAGATGA
TGTGTGCAGGCATCCCGGAAGGGGGTGTGGACACCTGCCAGGGTGACAGTGGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGG
TGGGCATCGTTAGTTGGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGAGTATACACCAAGGTCTCAGCCTATCTCAACTGGATCTACA
ATGTCTGGAAGGCTGAGCTGTAATGCTGCTGCCCCTTTGCAGTGCTGGGAGCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAA
AGTCAGACACAGAGCAAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGCCTCAGCATTTCTTGGAGCAGCAAAGGGCCTCAATTCCTAT
AAGAGACCCTCGCAGCCCAGAGGCGCCCAGAGGAAGTCAGCAGCCCTAGCTCGGCCACACTTGGTGCTCCCAGCATCCCAGGGAGAGACA

>In-frame_ENST00000299240_ENST00000523251_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(amino acids)=329AA_start in transcript=23_stop in transcript=1012
MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQEATVNYLKELEKQLVAQK
IHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDIRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKD
NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEG

--------------------------------------------------------------
>In-frame_ENST00000299240_ENST00000437212_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(transcript)=1559nt_BP=442nt
AGCGGCCCGGCCGGGGGGGCAAGATGGCGGCGGCAGTAGGGGTTCGTGGCCGGTACGAGCTGCCGCCTTGCTCCGGCCCAGGCTGGCTCC
TCAGCCTTTCCGCCTTGCTGAGTGTGGCGGCACGAGGGGCCTTCGCCACCACGCACTGGGTCGTCACGGAGGACGGGAAAATCCAGCAGC
AGGTGGATTCACCAATGAACTTGAAGCATCCTCATGACCTAGTCATATTAATGAGACAAGAAGCAACAGTTAACTACCTCAAAGAATTAG
AGAAACAATTAGTTGCTCAAAAAATTCACATAGAAGAGAATGAGGACAGAGACACAGGACTGGAACAGAGACATAATAAAGAAGACCCAG
ACTGCATCAAAGCCAAGGTGCCCTTAGGGGACCTGGATCTATATGATGGCACATACATAACTTTGGAGAGCAAAGACATCAGGAAACATA
CCGATGTGTTCAACTGGAAGGTGCGGGCAGGCTCAGACAAACTGGGCAGCTTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAAT
TCAACCCCATGTACCCCAAAGACAATGACATCGCCCTCATGAAGCTGCAGTTCCCACTCACTTTCTCAGGCACAGTCAGGCCCATCTGTC
TGCCCTTCTTTGATGAGGAGCTCACTCCAGCCACCCCACTCTGGATCATTGGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTG
ACATACTGCTGCAGGCGTCAGTCCAGGTCATTGACAGCACACGGTGCAATGCAGACGATGCGTACCAGGGGGAAGTCACCGAGAAGATGA
TGTGTGCAGGCATCCCGGAAGGGGGTGTGGACACCTGCCAGGGTGACAGTGGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGG
TGGGCATCGTTAGTTGGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGAGTATACACCAAGGTCTCAGCCTATCTCAACTGGATCTACA
ATGTCTGGAAGGCTGAGCTGTAATGCTGCTGCCCCTTTGCAGTGCTGGGAGCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAA
AGTCAGACACAGAGCAAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGCCTCAGCATTTCTTGGAGCAGCAAAGGGCCTCAATTCCTAT
AAGAGACCCTCGCAGCCCAGAGGCGCCCAGAGGAAGTCAGCAGCCCTAGCTCGGCCACACTTGGTGCTCCCAGCATCCCAGGGAGAGACA
CAGCCCACTGAACAAGGTCTCAGGGGTATTGCTAAGCCAAGAAGGAACTTTCCCACACTACTGAATGGAAGCAGGCTGTCTTGTAAAAGC
CCAGATCACTGTGGGCTGGAGAGGAGAAGGAAAGGGTCTGCGCCAGCCCTGTCCGTCTTCACCCATCCCCAAGCCTACTAGAGCAAGAAA
CCAGTTGTAATATAAAATGCACTGCCCTACTGTTGGTATGACTACCGTTACCTACTGTTGTCATTGTTATTACAGCTATGGCCACTATTA

>In-frame_ENST00000299240_ENST00000437212_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(amino acids)=329AA_start in transcript=23_stop in transcript=1012
MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQEATVNYLKELEKQLVAQK
IHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDIRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKD
NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEG

--------------------------------------------------------------
>In-frame_ENST00000299240_ENST00000522824_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(transcript)=1557nt_BP=442nt
AGCGGCCCGGCCGGGGGGGCAAGATGGCGGCGGCAGTAGGGGTTCGTGGCCGGTACGAGCTGCCGCCTTGCTCCGGCCCAGGCTGGCTCC
TCAGCCTTTCCGCCTTGCTGAGTGTGGCGGCACGAGGGGCCTTCGCCACCACGCACTGGGTCGTCACGGAGGACGGGAAAATCCAGCAGC
AGGTGGATTCACCAATGAACTTGAAGCATCCTCATGACCTAGTCATATTAATGAGACAAGAAGCAACAGTTAACTACCTCAAAGAATTAG
AGAAACAATTAGTTGCTCAAAAAATTCACATAGAAGAGAATGAGGACAGAGACACAGGACTGGAACAGAGACATAATAAAGAAGACCCAG
ACTGCATCAAAGCCAAGGTGCCCTTAGGGGACCTGGATCTATATGATGGCACATACATAACTTTGGAGAGCAAAGACATCAGGAAACATA
CCGATGTGTTCAACTGGAAGGTGCGGGCAGGCTCAGACAAACTGGGCAGCTTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAAT
TCAACCCCATGTACCCCAAAGACAATGACATCGCCCTCATGAAGCTGCAGTTCCCACTCACTTTCTCAGGCACAGTCAGGCCCATCTGTC
TGCCCTTCTTTGATGAGGAGCTCACTCCAGCCACCCCACTCTGGATCATTGGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTG
ACATACTGCTGCAGGCGTCAGTCCAGGTCATTGACAGCACACGGTGCAATGCAGACGATGCGTACCAGGGGGAAGTCACCGAGAAGATGA
TGTGTGCAGGCATCCCGGAAGGGGGTGTGGACACCTGCCAGGGTGACAGTGGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGG
TGGGCATCGTTAGTTGGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGAGTATACACCAAGGTCTCAGCCTATCTCAACTGGATCTACA
ATGTCTGGAAGGCTGAGCTGTAATGCTGCTGCCCCTTTGCAGTGCTGGGAGCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAA
AGTCAGACACAGAGCAAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGCCTCAGCATTTCTTGGAGCAGCAAAGGGCCTCAATTCCTAT
AAGAGACCCTCGCAGCCCAGAGGCGCCCAGAGGAAGTCAGCAGCCCTAGCTCGGCCACACTTGGTGCTCCCAGCATCCCAGGGAGAGACA
CAGCCCACTGAACAAGGTCTCAGGGGTATTGCTAAGCCAAGAAGGAACTTTCCCACACTACTGAATGGAAGCAGGCTGTCTTGTAAAAGC
CCAGATCACTGTGGGCTGGAGAGGAGAAGGAAAGGGTCTGCGCCAGCCCTGTCCGTCTTCACCCATCCCCAAGCCTACTAGAGCAAGAAA
CCAGTTGTAATATAAAATGCACTGCCCTACTGTTGGTATGACTACCGTTACCTACTGTTGTCATTGTTATTACAGCTATGGCCACTATTA

>In-frame_ENST00000299240_ENST00000522824_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(amino acids)=329AA_start in transcript=23_stop in transcript=1012
MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQEATVNYLKELEKQLVAQK
IHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDIRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKD
NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEG

--------------------------------------------------------------
>In-frame_ENST00000039989_ENST00000534111_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(transcript)=4981nt_BP=433nt
GCCGGGGGGGCAAGATGGCGGCGGCAGTAGGGGTTCGTGGCCGGTACGAGCTGCCGCCTTGCTCCGGCCCAGGCTGGCTCCTCAGCCTTT
CCGCCTTGCTGAGTGTGGCGGCACGAGGGGCCTTCGCCACCACGCACTGGGTCGTCACGGAGGACGGGAAAATCCAGCAGCAGGTGGATT
CACCAATGAACTTGAAGCATCCTCATGACCTAGTCATATTAATGAGACAAGAAGCAACAGTTAACTACCTCAAAGAATTAGAGAAACAAT
TAGTTGCTCAAAAAATTCACATAGAAGAGAATGAGGACAGAGACACAGGACTGGAACAGAGACATAATAAAGAAGACCCAGACTGCATCA
AAGCCAAGGTGCCCTTAGGGGACCTGGATCTATATGATGGCACATACATAACTTTGGAGAGCAAAGACATCAGGAAACATACCGATGTGT
TCAACTGGAAGGTGCGGGCAGGCTCAGACAAACTGGGCAGCTTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAATTCAACCCCA
TGTACCCCAAAGACAATGACATCGCCCTCATGAAGCTGCAGTTCCCACTCACTTTCTCAGGCACAGTCAGGCCCATCTGTCTGCCCTTCT
TTGATGAGGAGCTCACTCCAGCCACCCCACTCTGGATCATTGGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTGACATACTGC
TGCAGGCGTCAGTCCAGGTCATTGACAGCACACGGTGCAATGCAGACGATGCGTACCAGGGGGAAGTCACCGAGAAGATGATGTGTGCAG
GCATCCCGGAAGGGGGTGTGGACACCTGCCAGGGTGACAGTGGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGGTGGGCATCG
TTAGTTGGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGAGTATACACCAAGGTCTCAGCCTATCTCAACTGGATCTACAATGTCTGGA
AGGCTGAGCTGTAATGCTGCTGCCCCTTTGCAGTGCTGGGAGCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAAAGTCAGACA
CAGAGCAAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGCCTCAGCATTTCTTGGAGCAGCAAAGGGCCTCAATTCCTATAAGAGACCC
TCGCAGCCCAGAGGCGCCCAGAGGAAGTCAGCAGCCCTAGCTCGGCCACACTTGGTGCTCCCAGCATCCCAGGGAGAGACACAGCCCACT
GAACAAGGTCTCAGGGGTATTGCTAAGCCAAGAAGGAACTTTCCCACACTACTGAATGGAAGCAGGCTGTCTTGTAAAAGCCCAGATCAC
TGTGGGCTGGAGAGGAGAAGGAAAGGGTCTGCGCCAGCCCTGTCCGTCTTCACCCATCCCCAAGCCTACTAGAGCAAGAAACCAGTTGTA
ATATAAAATGCACTGCCCTACTGTTGGTATGACTACCGTTACCTACTGTTGTCATTGTTATTACAGCTATGGCCACTATTATTAAAGAGC
TGTGTAACATCTCTGGCATAGGCTAGCTGGAATGCTTGATAAGAACTGAGCTGGGATGATTGAACTTTCATTCTTTGGCTTGGGGAGAAA
AGAAGTCCTGGGGAAGCAATTGAGTCTCAAAGTAGAGGCAGGGGAAAAAAGAGTTAGGGAGACCAGATCTGCTGAGTGGCAGCAAGAGTG
AGCTGCAGATTACAGAAACCAGGGTGAGCAAGTTTGAGTCCCACACAGGGCCTTCTCCCTTTGCCTCTTTCCCTCCCTCCCTGCCTGTGA
TAATCAGCCAGGAGCCAGGGATAACCTATGACTTGGGAAAGAGATGAGTTAGGCAGTCAAGGGTGACATTCAATCAGGGATCCACAAGTG
GCTGGAAAGAAATGCTGGTCCTGTGTCCTAACTTTTTCCGCCTGGAGAGCCCTCAGTGTGGCTTCTTACATTTAAAAAACAAAAAGGATC
AGCTGCCAGGTGTGAGGCAGTCCCCAAGCTGAGTTGTGAGGATGTAAGCATGAATAAGTCCCTGCACTCAAAATGGTCAAAGAATTAAAC
CCCATGGACTTTTTTGGCATCTGTATGAAAGCTTGGGTTTTCTGAGGACTGTCTTGCTATAGTTAAGTCAGATCCTAGATGAAATATACT
TGTTCATACTGTACTAGGTTCTTAGGAAACAACAGAATTCCTCAAATGCCAAAAACAAAGAAAATAGAAACCCAGAAAACAAAACAAAAT
AAAACAAAACCATCAGAACTGTGAGTGGAAACTAAGGTGATGATCTGGGAGCAATACACTAAAATCTTGGGTCGAGACCTATATGAAGGC
TGGCAGTGGAGCTAAACCTGGACACACTGAAGACAAGGGAGCTGAACCAGGGCTCCTACATGAAGCAGGGATAACTGATGGCAGTAAATG
TGGTCTCAAATTGCAGATGGTCTGGAGGAAAATTTCCCAAATTTAGAGCCTCAGGATTCCCAAAGATCCTCCAAATATGAGCTCACAATC
AAAGATCAGAGACGTTGAAAAATAAAAAACACCTTAAGTGGGCAGCATAAAAAACAGCTAATTTAGAACCCCAAAGGCTTCAGATGTCAG
AATATTAGAGACTTATGATAATAAGCAATATTTGCAGAGTATTTGTATGTGCCAGACACTATTGTAAGTGCTTCATCATGTACTGATTCA
TTTAATACTCACAGAAATCTGTGAGATGGGTATTATTCTTATCCTCACTCTATGGATTAAAAAAACTAAGGCACAAAGTGGTTAAGCTCC
TTGCCTGAGATTATAGACTGTAAGTTGAACGTGAGCACTTGGAATACAGAGTTCATGCTGTAAACTACCACACTATAGGGCCTCCAATAT
GATAATTTATAAAATATTTGAATAAAAAATGAATACTAGTTCCACATTTTAAAATCATGTTTAACTGTGGTCAAATGCACATAACACAAG
TTGCCATCTTCACCATTTTTAGGTGTATAGTTCAGTGGTGTTATGTACATTCACACTATTGTGCAGTCATCACCACCATCCATCTCCAGA
ACAGAAACTCAGTACCCATCAAACAACTCTCCATTTCCCCCTCCTCCCAATCTCTGGCAACCACCATTGTGCTTTCAGTCTCTGTGAACT
GGATTACTCTGGGTACCTCATTTAAGTGAAGTCATGCAGTATTGGTCTTTTTGTACTTGTTTTATTTCACTTCACATTGTGTCTTCAAGT
TTCACCCATGTTGTAGCATGTGTCAGAATTTCTTCCCTTTTTAGACTAAATAATATTCTATTGTTTATACGAACATTCAGGTTACTTCTA
TCTTTTGGCTATTGTGAATTATGCTGCTGTGAACATGGGTGTACAAGTATCTCTTTGAGGCCCTGCTTTCAATTCTCTTGGGTATATTCC
CAGAAGTGGAATTGCTGGATCATATGGTAATTCTATTTTGAATTTTTTGAGGAACTGATATATTGCTTTCCATAGAGACTGCACCATTTT
ACATTCCCATCAACAGTTTGCAGGAGTTACTATTTCTCCATATCCCCCCTAACACTTGCTATTTTCTGTTAAAAATGGATATCTTAATAA
TCAAGCAAAAATAACAGGCAGATTTGAAAAAGAACTGAATACAGCTTTTAGAAATAAAAACTATAATTATAAAAATAAAAAACTAAGTGG
ATGGGGTAAATAACAATTAAAACACCAATTAAGAGAGAACAAATGAACTGGAAGATAAATTGAAGAAGTGACTAGGCTTAACAGCAGAGA
GAGATAAGGAGATTAAAAATATGAAAACAAGGCCAGGAGCAATGAAGCCTAGAATGGTAAATTCTAACATATCCAGAATCCCAGAAAGAG
AGAATCAAGACAATGAGAGAGAGACAGTACCAAAGAGATAAGAGCTGAGAATGTTCCAGAATTGATAAAAGGTGTGAATCCACAGAACAT
ACACCACCATAGTGTACACGCATACAACCAAGGTGGAAAAATTAGAATAAATCCACACCTATGTACATTATAATGAAACTGCAGAACACC
AAAGACAAAAAGAAACTCCTTATAGCAGCAGAGAGAAAACCCAGACCACCCACAGTACCACAAATCTACCACAATTAGACTGACAACAGG
CTTTCCCACAGCAATAAAGGAGCTAGAAGTCAGTGGAAGTATATCTCCAGCATGCCAAAAGATAACAATCAATCAGGGATTGTGAACCCT
ACAAAACTATCTTTCAAGAATAAAGGCATTTTCAAGAAAACAAAAACAGACTTTACCATCAACAAACCTTCTCTAAAAGAATATATAAAG
CATTTACTTTAGGAAGAAGGAAAATGATCCTAAAAGGAAGAACCAAGAAGCAAGTAGCAATAGTGAGGCAATTGTGAAAATGTAGGTAAG
TCTAAACACACTCTGTCTACTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTATTTTGAGACTGAGTCTTGCCCTGTCACCCAGACTGGA
GTGCAGTGGCAGGATCTTGGCTCACTGCTATCTCCACCTCCCAGGTTCAAGTGATTCTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTAC
ATGCACATGCCACCATATCCGGCTAATTTTTGAATTTTTAGTAGAGATGGGGTTTCACTGTGTTGGCCAGGCCGGTCTCAAACTCCCGAC
CTCAAGTGATCCCCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGTCTACATATTATTAAAATAACAATAATATTTATTTTGT
GGGTTAATTTTTTTTGAAACAGATATTGAATTTATTGGTTGGCTATGAGTAGAAAAATACATCAGTAAAGAAAAAAGACCCTGTATATAA
ATATAATACTAGCTAGTTAAAATTTGACCAAGAAGTTTCCATTGTGGGTTAATTTTTAAAGGCCTAACTGAAATATGGAGTAACCACAGC

>In-frame_ENST00000039989_ENST00000534111_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(amino acids)=329AA_start in transcript=14_stop in transcript=1003
MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQEATVNYLKELEKQLVAQK
IHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDIRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKD
NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEG

--------------------------------------------------------------
>In-frame_ENST00000039989_ENST00000522307_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(transcript)=1182nt_BP=433nt
GCCGGGGGGGCAAGATGGCGGCGGCAGTAGGGGTTCGTGGCCGGTACGAGCTGCCGCCTTGCTCCGGCCCAGGCTGGCTCCTCAGCCTTT
CCGCCTTGCTGAGTGTGGCGGCACGAGGGGCCTTCGCCACCACGCACTGGGTCGTCACGGAGGACGGGAAAATCCAGCAGCAGGTGGATT
CACCAATGAACTTGAAGCATCCTCATGACCTAGTCATATTAATGAGACAAGAAGCAACAGTTAACTACCTCAAAGAATTAGAGAAACAAT
TAGTTGCTCAAAAAATTCACATAGAAGAGAATGAGGACAGAGACACAGGACTGGAACAGAGACATAATAAAGAAGACCCAGACTGCATCA
AAGCCAAGGTGCCCTTAGGGGACCTGGATCTATATGATGGCACATACATAACTTTGGAGAGCAAAGACATCAGGAAACATACCGATGTGT
TCAACTGGAAGGTGCGGGCAGGCTCAGACAAACTGGGCAGCTTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAATTCAACCCCA
TGTACCCCAAAGACAATGACATCGCCCTCATGAAGCTGCAGTTCCCACTCACTTTCTCAGGCACAGTCAGGCCCATCTGTCTGCCCTTCT
TTGATGAGGAGCTCACTCCAGCCACCCCACTCTGGATCATTGGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTGACATACTGC
TGCAGGCGTCAGTCCAGGTCATTGACAGCACACGGTGCAATGCAGACGATGCGTACCAGGGGGAAGTCACCGAGAAGATGATGTGTGCAG
GCATCCCGGAAGGGGGTGTGGACACCTGCCAGGGTGACAGTGGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGGTGGGCATCG
TTAGTTGGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGAGTATACACCAAGGTCTCAGCCTATCTCAACTGGATCTACAATGTCTGGA
AGGCTGAGCTGTAATGCTGCTGCCCCTTTGCAGTGCTGGGAGCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAAAGTCAGACA
CAGAGCAAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGCCTCAGCATTTCTTGGAGCAGCAAAGGGCCTCAATTCCTATAAGAGACCC

>In-frame_ENST00000039989_ENST00000522307_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(amino acids)=329AA_start in transcript=14_stop in transcript=1003
MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQEATVNYLKELEKQLVAQK
IHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDIRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKD
NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEG

--------------------------------------------------------------
>In-frame_ENST00000039989_ENST00000523251_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(transcript)=1273nt_BP=433nt
GCCGGGGGGGCAAGATGGCGGCGGCAGTAGGGGTTCGTGGCCGGTACGAGCTGCCGCCTTGCTCCGGCCCAGGCTGGCTCCTCAGCCTTT
CCGCCTTGCTGAGTGTGGCGGCACGAGGGGCCTTCGCCACCACGCACTGGGTCGTCACGGAGGACGGGAAAATCCAGCAGCAGGTGGATT
CACCAATGAACTTGAAGCATCCTCATGACCTAGTCATATTAATGAGACAAGAAGCAACAGTTAACTACCTCAAAGAATTAGAGAAACAAT
TAGTTGCTCAAAAAATTCACATAGAAGAGAATGAGGACAGAGACACAGGACTGGAACAGAGACATAATAAAGAAGACCCAGACTGCATCA
AAGCCAAGGTGCCCTTAGGGGACCTGGATCTATATGATGGCACATACATAACTTTGGAGAGCAAAGACATCAGGAAACATACCGATGTGT
TCAACTGGAAGGTGCGGGCAGGCTCAGACAAACTGGGCAGCTTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAATTCAACCCCA
TGTACCCCAAAGACAATGACATCGCCCTCATGAAGCTGCAGTTCCCACTCACTTTCTCAGGCACAGTCAGGCCCATCTGTCTGCCCTTCT
TTGATGAGGAGCTCACTCCAGCCACCCCACTCTGGATCATTGGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTGACATACTGC
TGCAGGCGTCAGTCCAGGTCATTGACAGCACACGGTGCAATGCAGACGATGCGTACCAGGGGGAAGTCACCGAGAAGATGATGTGTGCAG
GCATCCCGGAAGGGGGTGTGGACACCTGCCAGGGTGACAGTGGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGGTGGGCATCG
TTAGTTGGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGAGTATACACCAAGGTCTCAGCCTATCTCAACTGGATCTACAATGTCTGGA
AGGCTGAGCTGTAATGCTGCTGCCCCTTTGCAGTGCTGGGAGCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAAAGTCAGACA
CAGAGCAAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGCCTCAGCATTTCTTGGAGCAGCAAAGGGCCTCAATTCCTATAAGAGACCC
TCGCAGCCCAGAGGCGCCCAGAGGAAGTCAGCAGCCCTAGCTCGGCCACACTTGGTGCTCCCAGCATCCCAGGGAGAGACACAGCCCACT

>In-frame_ENST00000039989_ENST00000523251_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(amino acids)=329AA_start in transcript=14_stop in transcript=1003
MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQEATVNYLKELEKQLVAQK
IHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDIRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKD
NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEG

--------------------------------------------------------------
>In-frame_ENST00000039989_ENST00000437212_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(transcript)=1550nt_BP=433nt
GCCGGGGGGGCAAGATGGCGGCGGCAGTAGGGGTTCGTGGCCGGTACGAGCTGCCGCCTTGCTCCGGCCCAGGCTGGCTCCTCAGCCTTT
CCGCCTTGCTGAGTGTGGCGGCACGAGGGGCCTTCGCCACCACGCACTGGGTCGTCACGGAGGACGGGAAAATCCAGCAGCAGGTGGATT
CACCAATGAACTTGAAGCATCCTCATGACCTAGTCATATTAATGAGACAAGAAGCAACAGTTAACTACCTCAAAGAATTAGAGAAACAAT
TAGTTGCTCAAAAAATTCACATAGAAGAGAATGAGGACAGAGACACAGGACTGGAACAGAGACATAATAAAGAAGACCCAGACTGCATCA
AAGCCAAGGTGCCCTTAGGGGACCTGGATCTATATGATGGCACATACATAACTTTGGAGAGCAAAGACATCAGGAAACATACCGATGTGT
TCAACTGGAAGGTGCGGGCAGGCTCAGACAAACTGGGCAGCTTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAATTCAACCCCA
TGTACCCCAAAGACAATGACATCGCCCTCATGAAGCTGCAGTTCCCACTCACTTTCTCAGGCACAGTCAGGCCCATCTGTCTGCCCTTCT
TTGATGAGGAGCTCACTCCAGCCACCCCACTCTGGATCATTGGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTGACATACTGC
TGCAGGCGTCAGTCCAGGTCATTGACAGCACACGGTGCAATGCAGACGATGCGTACCAGGGGGAAGTCACCGAGAAGATGATGTGTGCAG
GCATCCCGGAAGGGGGTGTGGACACCTGCCAGGGTGACAGTGGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGGTGGGCATCG
TTAGTTGGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGAGTATACACCAAGGTCTCAGCCTATCTCAACTGGATCTACAATGTCTGGA
AGGCTGAGCTGTAATGCTGCTGCCCCTTTGCAGTGCTGGGAGCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAAAGTCAGACA
CAGAGCAAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGCCTCAGCATTTCTTGGAGCAGCAAAGGGCCTCAATTCCTATAAGAGACCC
TCGCAGCCCAGAGGCGCCCAGAGGAAGTCAGCAGCCCTAGCTCGGCCACACTTGGTGCTCCCAGCATCCCAGGGAGAGACACAGCCCACT
GAACAAGGTCTCAGGGGTATTGCTAAGCCAAGAAGGAACTTTCCCACACTACTGAATGGAAGCAGGCTGTCTTGTAAAAGCCCAGATCAC
TGTGGGCTGGAGAGGAGAAGGAAAGGGTCTGCGCCAGCCCTGTCCGTCTTCACCCATCCCCAAGCCTACTAGAGCAAGAAACCAGTTGTA
ATATAAAATGCACTGCCCTACTGTTGGTATGACTACCGTTACCTACTGTTGTCATTGTTATTACAGCTATGGCCACTATTATTAAAGAGC

>In-frame_ENST00000039989_ENST00000437212_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(amino acids)=329AA_start in transcript=14_stop in transcript=1003
MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQEATVNYLKELEKQLVAQK
IHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDIRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKD
NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEG

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>In-frame_ENST00000039989_ENST00000522824_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(transcript)=1548nt_BP=433nt
GCCGGGGGGGCAAGATGGCGGCGGCAGTAGGGGTTCGTGGCCGGTACGAGCTGCCGCCTTGCTCCGGCCCAGGCTGGCTCCTCAGCCTTT
CCGCCTTGCTGAGTGTGGCGGCACGAGGGGCCTTCGCCACCACGCACTGGGTCGTCACGGAGGACGGGAAAATCCAGCAGCAGGTGGATT
CACCAATGAACTTGAAGCATCCTCATGACCTAGTCATATTAATGAGACAAGAAGCAACAGTTAACTACCTCAAAGAATTAGAGAAACAAT
TAGTTGCTCAAAAAATTCACATAGAAGAGAATGAGGACAGAGACACAGGACTGGAACAGAGACATAATAAAGAAGACCCAGACTGCATCA
AAGCCAAGGTGCCCTTAGGGGACCTGGATCTATATGATGGCACATACATAACTTTGGAGAGCAAAGACATCAGGAAACATACCGATGTGT
TCAACTGGAAGGTGCGGGCAGGCTCAGACAAACTGGGCAGCTTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAATTCAACCCCA
TGTACCCCAAAGACAATGACATCGCCCTCATGAAGCTGCAGTTCCCACTCACTTTCTCAGGCACAGTCAGGCCCATCTGTCTGCCCTTCT
TTGATGAGGAGCTCACTCCAGCCACCCCACTCTGGATCATTGGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTGACATACTGC
TGCAGGCGTCAGTCCAGGTCATTGACAGCACACGGTGCAATGCAGACGATGCGTACCAGGGGGAAGTCACCGAGAAGATGATGTGTGCAG
GCATCCCGGAAGGGGGTGTGGACACCTGCCAGGGTGACAGTGGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGGTGGGCATCG
TTAGTTGGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGAGTATACACCAAGGTCTCAGCCTATCTCAACTGGATCTACAATGTCTGGA
AGGCTGAGCTGTAATGCTGCTGCCCCTTTGCAGTGCTGGGAGCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAAAGTCAGACA
CAGAGCAAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGCCTCAGCATTTCTTGGAGCAGCAAAGGGCCTCAATTCCTATAAGAGACCC
TCGCAGCCCAGAGGCGCCCAGAGGAAGTCAGCAGCCCTAGCTCGGCCACACTTGGTGCTCCCAGCATCCCAGGGAGAGACACAGCCCACT
GAACAAGGTCTCAGGGGTATTGCTAAGCCAAGAAGGAACTTTCCCACACTACTGAATGGAAGCAGGCTGTCTTGTAAAAGCCCAGATCAC
TGTGGGCTGGAGAGGAGAAGGAAAGGGTCTGCGCCAGCCCTGTCCGTCTTCACCCATCCCCAAGCCTACTAGAGCAAGAAACCAGTTGTA
ATATAAAATGCACTGCCCTACTGTTGGTATGACTACCGTTACCTACTGTTGTCATTGTTATTACAGCTATGGCCACTATTATTAAAGAGC

>In-frame_ENST00000039989_ENST00000522824_TCGA-2J-AABP-01A_TTC17_chr11_43411371_-_TMPRSS4_chr11_117983984_length(amino acids)=329AA_start in transcript=14_stop in transcript=1003
MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQEATVNYLKELEKQLVAQK
IHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDIRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKD
NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEG

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Fusion Gene PPI Analysis for TTC17-TMPRSS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTC17-TMPRSS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTC17-TMPRSS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTMPRSS4C4755252Autosomal recessive cerebral atrophy1ORPHANET