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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTC28-ANKRD17 (FusionGDB2 ID:94303)

Fusion Gene Summary for TTC28-ANKRD17

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC28-ANKRD17
Fusion gene ID: 94303
HgeneTgene
Gene symbol

TTC28

ANKRD17

Gene ID

23331

26057

Gene nametetratricopeptide repeat domain 28ankyrin repeat domain 17
SynonymsTPRBKGTAR|MASK2|NY-BR-16
Cytomap

22q12.1

4q13.3

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 28TPR repeat protein 28TPR repeat-containing big gene cloned at KeioTPR-containing big gene cloned at Keioankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16
Modification date2020031320200313
UniProtAcc.

O75179

Ensembl transtripts involved in fusion geneENST00000397906, ENST00000490475, 
ENST00000358602, ENST00000509867, 
ENST00000330838, ENST00000514252, 
Fusion gene scores* DoF score46 X 33 X 13=1973412 X 18 X 5=1080
# samples 5321
** MAII scorelog2(53/19734*10)=-5.218547244106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1080*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTC28 [Title/Abstract] AND ANKRD17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTC28(29025539)-ANKRD17(73968264), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANKRD17

GO:0042742

defense response to bacterium

23711367

TgeneANKRD17

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

22328336

TgeneANKRD17

GO:0045087

innate immune response

23711367

TgeneANKRD17

GO:1900245

positive regulation of MDA-5 signaling pathway

22328336

TgeneANKRD17

GO:1900246

positive regulation of RIG-I signaling pathway

22328336


check buttonFusion gene breakpoints across TTC28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ANKRD17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-AZ-6598-11ATTC28chr22

29025539

-ANKRD17chr4

73968264

-


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Fusion Gene ORF analysis for TTC28-ANKRD17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000397906ENST00000358602TTC28chr22

29025539

-ANKRD17chr4

73968264

-
In-frameENST00000397906ENST00000509867TTC28chr22

29025539

-ANKRD17chr4

73968264

-
In-frameENST00000397906ENST00000330838TTC28chr22

29025539

-ANKRD17chr4

73968264

-
5CDS-intronENST00000397906ENST00000514252TTC28chr22

29025539

-ANKRD17chr4

73968264

-
intron-3CDSENST00000490475ENST00000358602TTC28chr22

29025539

-ANKRD17chr4

73968264

-
intron-3CDSENST00000490475ENST00000509867TTC28chr22

29025539

-ANKRD17chr4

73968264

-
intron-3CDSENST00000490475ENST00000330838TTC28chr22

29025539

-ANKRD17chr4

73968264

-
intron-intronENST00000490475ENST00000514252TTC28chr22

29025539

-ANKRD17chr4

73968264

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397906TTC28chr2229025539-ENST00000358602ANKRD17chr473968264-67895239439331279
ENST00000397906TTC28chr2229025539-ENST00000509867ANKRD17chr473968264-44795239439331279
ENST00000397906TTC28chr2229025539-ENST00000330838ANKRD17chr473968264-44795239439331279

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397906ENST00000358602TTC28chr2229025539-ANKRD17chr473968264-0.0001926770.9998073
ENST00000397906ENST00000509867TTC28chr2229025539-ANKRD17chr473968264-0.001272540.9987275
ENST00000397906ENST00000330838TTC28chr2229025539-ANKRD17chr473968264-0.001272540.9987275

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Fusion Genomic Features for TTC28-ANKRD17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TTC28-ANKRD17


check button Go to

FGviewer for the breakpoints of chr22:29025539-chr4:73968264

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANKRD17

O75179

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-22358_91127.02482.0RepeatNote=TPR 1
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-22393_125127.02482.0RepeatNote=TPR 2
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331442_15261216.02353.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331603_17001216.02353.0Compositional biasNote=Ser-rich
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331950_21061216.02353.0Compositional biasNote=Ser-rich
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331966_20331216.02353.0Compositional biasNote=Thr-rich
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341603_17001467.02604.0Compositional biasNote=Ser-rich
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341950_21061467.02604.0Compositional biasNote=Ser-rich
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341966_20331467.02604.0Compositional biasNote=Thr-rich
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331725_17891216.02353.0DomainKH
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341725_17891467.02604.0DomainKH
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331217_12461216.02353.0RepeatNote=ANK 20
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331251_12801216.02353.0RepeatNote=ANK 21
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331284_13131216.02353.0RepeatNote=ANK 22
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331319_13481216.02353.0RepeatNote=ANK 23
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331352_13811216.02353.0RepeatNote=ANK 24
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331385_14141216.02353.0RepeatNote=ANK 25

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-2231948_2006127.02482.0Compositional biasNote=Ser-rich
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-2232201_2335127.02482.0Compositional biasNote=Ser-rich
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-2231037_1070127.02482.0RepeatNote=TPR 25
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-2231077_1110127.02482.0RepeatNote=TPR 26
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-2231117_1150127.02482.0RepeatNote=TPR 27
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-2231169_1202127.02482.0RepeatNote=TPR 28
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223126_159127.02482.0RepeatNote=TPR 3
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223196_229127.02482.0RepeatNote=TPR 4
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223234_267127.02482.0RepeatNote=TPR 5
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223274_307127.02482.0RepeatNote=TPR 6
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223314_347127.02482.0RepeatNote=TPR 7
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223354_387127.02482.0RepeatNote=TPR 8
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223394_427127.02482.0RepeatNote=TPR 9
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223434_467127.02482.0RepeatNote=TPR 10
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223474_507127.02482.0RepeatNote=TPR 11
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223514_547127.02482.0RepeatNote=TPR 12
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223554_587127.02482.0RepeatNote=TPR 13
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223594_627127.02482.0RepeatNote=TPR 14
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223634_667127.02482.0RepeatNote=TPR 15
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223674_707127.02482.0RepeatNote=TPR 16
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223714_747127.02482.0RepeatNote=TPR 17
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223754_787127.02482.0RepeatNote=TPR 18
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223794_827127.02482.0RepeatNote=TPR 19
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223834_867127.02482.0RepeatNote=TPR 20
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223877_910127.02482.0RepeatNote=TPR 21
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223917_950127.02482.0RepeatNote=TPR 22
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223957_990127.02482.0RepeatNote=TPR 23
HgeneTTC28chr22:29025539chr4:73968264ENST00000397906-223997_1030127.02482.0RepeatNote=TPR 24
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341442_15261467.02604.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233858_10081216.02353.0Compositional biasNote=Gln-rich
TgeneANKRD17chr22:29025539chr4:73968264ENST00000330838223396_1101216.02353.0Compositional biasNote=Gly-rich
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334858_10081467.02604.0Compositional biasNote=Gln-rich
TgeneANKRD17chr22:29025539chr4:73968264ENST00000358602233496_1101467.02604.0Compositional biasNote=Gly-rich
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331082_11111216.02353.0RepeatNote=ANK 16
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331115_11441216.02353.0RepeatNote=ANK 17
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331149_11781216.02353.0RepeatNote=ANK 18
TgeneANKRD17chr22:29025539chr4:73968264ENST0000033083822331182_12111216.02353.0RepeatNote=ANK 19
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233233_2621216.02353.0RepeatNote=ANK 1
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233266_2951216.02353.0RepeatNote=ANK 2
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233300_3291216.02353.0RepeatNote=ANK 3
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233333_3621216.02353.0RepeatNote=ANK 4
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233366_3951216.02353.0RepeatNote=ANK 5
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233400_4291216.02353.0RepeatNote=ANK 6
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233433_4621216.02353.0RepeatNote=ANK 7
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233466_4951216.02353.0RepeatNote=ANK 8
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233499_5281216.02353.0RepeatNote=ANK 9
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233533_5621216.02353.0RepeatNote=ANK 10
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233563_5921216.02353.0RepeatNote=ANK 11
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233596_6251216.02353.0RepeatNote=ANK 12
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233629_6581216.02353.0RepeatNote=ANK 13
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233663_6921216.02353.0RepeatNote=ANK 14
TgeneANKRD17chr22:29025539chr4:73968264ENST000003308382233696_7251216.02353.0RepeatNote=ANK 15
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341082_11111467.02604.0RepeatNote=ANK 16
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341115_11441467.02604.0RepeatNote=ANK 17
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341149_11781467.02604.0RepeatNote=ANK 18
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341182_12111467.02604.0RepeatNote=ANK 19
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341217_12461467.02604.0RepeatNote=ANK 20
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341251_12801467.02604.0RepeatNote=ANK 21
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341284_13131467.02604.0RepeatNote=ANK 22
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341319_13481467.02604.0RepeatNote=ANK 23
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341352_13811467.02604.0RepeatNote=ANK 24
TgeneANKRD17chr22:29025539chr4:73968264ENST0000035860223341385_14141467.02604.0RepeatNote=ANK 25
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334233_2621467.02604.0RepeatNote=ANK 1
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334266_2951467.02604.0RepeatNote=ANK 2
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334300_3291467.02604.0RepeatNote=ANK 3
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334333_3621467.02604.0RepeatNote=ANK 4
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334366_3951467.02604.0RepeatNote=ANK 5
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334400_4291467.02604.0RepeatNote=ANK 6
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334433_4621467.02604.0RepeatNote=ANK 7
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334466_4951467.02604.0RepeatNote=ANK 8
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334499_5281467.02604.0RepeatNote=ANK 9
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334533_5621467.02604.0RepeatNote=ANK 10
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334563_5921467.02604.0RepeatNote=ANK 11
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334596_6251467.02604.0RepeatNote=ANK 12
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334629_6581467.02604.0RepeatNote=ANK 13
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334663_6921467.02604.0RepeatNote=ANK 14
TgeneANKRD17chr22:29025539chr4:73968264ENST000003586022334696_7251467.02604.0RepeatNote=ANK 15


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Fusion Gene Sequence for TTC28-ANKRD17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000397906_ENST00000358602_TCGA-AZ-6598-11A_TTC28_chr22_29025539_-_ANKRD17_chr4_73968264_length(transcript)=6789nt_BP=523nt
GGGGGCGCGCGCGCGGTTTGGGGGCAGTGAGGGGCGCCGCGGCGGCGCGCAGCACGGCGGGAACATGGCGCGCGGAACCGGCGCGCGCGC
CTAGCTGGCGGGACCGTTAGCTCGAGGCGGACGCGGCCCGGGCCCCGTGGGGATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCA
AGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCGGCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTAT
TGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAGAAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGA
TTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAGAACTGCATCTTATACAGCAATAGATCTGCAGCCTACAT
GAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTTCTCAATCCCAAGTGGCCAAAGTTAAGGGAAGAAAGTCG
GAGGCTGGCTTTGGCTGCGAAAAGAGAAAAAAGAAAAGAGAAGAGAAGGAAGAAAAAGGAAGAACAAAGAAGGAAACTAGAAGAAATTGA
AGCCAAAAATAAAGAGAACTTTGAACTCCAAGCTGCTCAAGAAAAAGAAAAGCTTAAAGTTGAAGATGAGCCTGAAGTCTTGACAGAACC
TCCAAGTGCCACAACCACTACTACCATAGGTATATCTGCAACCTGGACAACTTTGGCAGGTTCTCATGGTAAAAGAAATAATACCATAAC
TACAACCAGTTCAAAGAGGAAAAACAGGAAAAATAAAATTACTCCAGAAAACGTTCAAATTATATTTGATGATCCACTACCAATTTCATA
CAGTCAGCCAGAGAAGGTGAATGGAGAGTCCAAGAGCAGCAGTACCAGCGAGAGTGGGGACAGTGATAACATGAGGATTTCCAGCTGCAG
CGATGAAAGTAGTAACAGCAACAGCAGTCGTAAGAGTGACAATCATTCACCAGCTGTGGTCACTACCACTGTGAGCAGCAAAAAGCAGCC
ATCAGTTCTTGTTACATTTCCAAAGGAAGAGAGAAAATCTGTTTCTGGCAAGGCTTCAATAAAATTGTCAGAAACTATCAGTGAAGGGAC
CAGTAATTCTCTATCTACTTGTACAAAATCTGGTCCATCTCCCCTTTCTTCTCCAAATGGGAAGTTAACAGTAGCAAGTCCTAAGCGTGG
GCAAAAGAGGGAAGAAGGATGGAAAGAAGTTGTAAGAAGGTCAAAGAAAGTATCTGTTCCATCAACTGTGATATCCAGAGTGATTGGAAG
AGGAGGCTGTAATATCAATGCTATTCGGGAGTTTACTGGTGCACACATAGATATTGATAAACAGAAAGACAAGACTGGAGACCGGATAAT
CACTATAAGGGGTGGCACTGAATCAACAAGACAAGCAACTCAATTGATTAATGCTTTGATCAAGGATCCAGACAAAGAAATTGATGAACT
TATTCCAAAGAATCGTTTGAAAAGCTCCTCAGCAAATTCCAAAATAGGGTCATCAGCACCTACCACCACTGCTGCTAACACTTCCTTAAT
GGGAATTAAAATGACAACTGTAGCTCTGTCATCAACATCTCAAACTGCCACAGCACTCACTGTGCCTGCAATTTCTTCTGCATCCACTCA
CAAAACCATTAAGAACCCAGTGAATAATGTGAGGCCTGGTTTTCCAGTTTCTCTTCCATTAGCATATCCTCCTCCACAGTTTGCACATGC
TTTGCTTGCTGCTCAGACTTTCCAGCAGATCCGTCCACCAAGGTTGCCCATGACCCACTTTGGAGGTACTTTTCCACCAGCTCAATCCAC
TTGGGGTCCGTTTCCTGTCAGGCCTTTGAGCCCTGCCAGAGCTACTAACTCGCCTAAGCCTCACATGGTGCCTCGCCATAGCAATCAGAA
TAGCAGTGGTTCTCAGGTGAATTCAGCAGGTTCTTTAACTTCAAGCCCAACAACTACAACCAGTTCATCAGCTTCAACGGTGCCTGGTAC
ATCTACAAATGGCAGTCCAAGTTCACCTTCTGTCCGAAGGCAGCTTTTTGTCACAGTTGTGAAGACATCCAATGCCACCACAACAACAGT
CACAACCACGGCAAGCAACAACAACACTGCACCCACAAATGCCACATATCCTATGCCTACTGCCAAAGAACACTATCCAGTATCATCCCC
ATCTTCCCCATCACCACCAGCCCAGCCAGGAGGGGTTTCTAGAAACAGCCCTTTGGATTGTGGATCAGCATCTCCAAATAAAGTGGCATC
TTCCTCCGAACAGGAAGCAGGTAGTCCACCAGTAGTAGAAACAACAAACACTAGACCTCCAAACAGCAGCAGTTCTTCTGGGAGTTCATC
AGCTCATTCTAATCAGCAACAACCTCCGGGATCTGTTTCTCAGGAACCAAGACCACCTCTTCAGCAGTCTCAGGTTCCTCCCCCGGAAGT
TAGAATGACTGTTCCTCCTTTAGCAACAAGTTCTGCTCCAGTGGCGGTGCCTTCTACTGCCCCAGTGACTTACCCTATGCCTCAGACACC
AATGGGATGCCCCCAGCCTACTCCTAAAATGGAAACCCCTGCTATTAGACCACCCCCTCATGGCACAACTGCCCCTCACAAGAATTCAGC
TTCAGTGCAAAATTCATCTGTTGCAGTCCTCAGTGTCAATCACATTAAAAGACCTCACAGTGTTCCCTCTTCTGTCCAGCTACCTTCGAC
CTTAAGTACACAAAGTGCTTGTCAGAATTCAGTACATCCAGCAAATAAGCCTATTGCTCCCAATTTCAGTGCCCCCTTACCATTTGGGCC
CTTTAGCACATTGTTTGAAAACAGCCCTACTTCTGCTCATGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTAT
GCTATCAGGAAAATCCTCATATTTGCCAAATTCAGATCCTTTACATCAGTCTGATACTTCCAAAGCTCCAGGTTTTAGACCACCATTACA
GAGACCTGCTCCAAGTCCCTCAGGTATTGTCAATATGGACTCGCCATATGGTTCTGTAACACCTTCTTCAACACATTTGGGAAACTTTGC
TTCAAACATTTCAGGAGGTCAGATGTACGGACCTGGGGCACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTTAACAGACAACATTTTTC
CCCGCTTAGTTTGTTGACTCCGTGTTCATCAGCATCAAATGATTCTTCTGCACAGTCAGTATCCTCGGGAGTTCGTGCACCATCTCCTGC
CCCATCATCAGTACCGTTAGGGTCAGAAAAGCCCAGCAATGTGTCTCAGGACAGGAAAGTTCCAGTCCCTATTGGGACTGAACGTTCTGC
ACGTATCAGGCAAACTGGAACGTCAGCTCCATCTGTTATTGGGAGCAATTTGTCTACATCAGTAGGACATAGTGGCATCTGGTCCTTTGA
AGGGATTGGTGGCAATCAAGACAAAGTAGACTGGTGTAACCCTGGGATGGGAAATCCTATGATCCACAGACCGATGTCTGACCCAGGAGT
ATTTTCACAACATCAAGCAATGGAGCGAGATAGTACAGGAATTGTAACTCCTTCTGGTACATTCCATCAGCATGTTCCTGCAGGCTACAT
GGACTTTCCTAAAGTTGGGGGTATGCCTTTTTCTGTGTATGGGAATGCAATGATTCCTCCAGTAGCACCTATCCCTGATGGTGCTGGAGG
ACCCATATTTAATGGCCCTCATGCTGCAGACCCTTCTTGGAACTCACTGATAAAGATGGTTTCCAGCTCCACGGAAAATAATGGCCCTCA
AACGGTGTGGACTGGACCCTGGGCACCTCACATGAACAGTGTGCATATGAACCAGCTTGGCTGATGAGGATCAGCTTGTTAGCCTGCAGA
TTCCTTTTCATTTGGAGGAAATCACAAGTGGCCGAAAAAAAAAATTATGCTCCCAAATCATTCTACTGATGTGCTTGACTGAAGTGTGTA
GGCTTTTTGCAGAAGATCTTACTAACTGACCTATTTTCTGTGAACATTTGTGACTGCCCATTCCCCATCATCATCCGTTTTACCTTAGTT
AGCATTTTTCTTATCATTTTTCTTTTTTTCTTTCCCTCTTCCCCTTTGGACATAACTTTCTGTTGAAGCTGTTCTTTGGCTGGTTGGTTT
TAGTACTGTAAACTGCTTCTGAGCAAACACGGAAATTTAGCAAAATTATGTAAACTTGATCCTGAAGTTTTAGAATGGCAAATAAATGTA
CAATTGTTTACATAACAGAAAAGGCTAAGCAGAAAGTAAATTTCAATATGTCAGTATAGAGGCTCTACTTTATGTAGACTTAAATTAATG
TGAGATATGTACCTTCATATTCAGAAATCTGGATGTTTCCTTCATACATTAAACTATTAATAAGCATAACTTTTCTACTGGTGTAATTTA
AGTATAAAGTAAAATAATGGGCATTATCATTGGATGTTTCCCCACATTGGCTTTTAAAATACCCATCTTGCTTTCTTTTTGGTTTATTTG
TAGCAAGGCACATATAGAAGAAGAAATTTCTGGCTTTTCCATGTTGTTTTATTACCTTTTCTCACTTTTAAAACTAATACAGACTTATCT
CCTCACTCCTTTTTCTCTCCTTACCTTTACCACTAATACCAGTAAAATTATCTTTCTGATAGTGAAAAGGTTCTGTCAAGATTTTCACTG
TAATGGCTGCTACAGAGATGGACCATCTTCATCATCACCAGTGGTTTCTTCTAATTATAAAATGTTTAAACTTTCTGAGAATTTAAAAAG
CCACCACTGTTCCCAGTCAGCATATACAAGCTCTTAATATTCTGTTTATTAAATAATTCAATGTACTATTTTATATTGGATGATATTGAT
TCTTAACATTGGCTTTTCAGTCATCAACAGTCAACATAAAAATTTCAATTTTCAGTAATTTAGTGGAAAATATCTTATTTCTTTTTTCAA
TTTTAAAGGCTTCCTGCTTTTTTACCCTTGTATATTATCAGTGAAAAGGATCAACAGTTAATTTGAGCCAAGTAATAAAAGAAATTCTGC
ATTTGTCACGAAGACAATTTATGGTAGACAGATAAATACACAGATTACAGTGTAAAGTCTCCATTTAACCTGTTTATAAAAGATACAAGG
CCACACTAAACTACTCAGTGGGATTTATATATTCCATCCACTTGAAACAATAAACAGTAATGTATCCAAGAAGATTATGTGTCCTACCCT
GTCTCATGGAAAAATTAATTATATGGTTGAAATGTAAAAGAAAGTAAGCATAAAAATCGAGTAATGTATATATCAATTTGTCTTCTTTTT
TTTTAATTAGACATAAAATTTCACACTGGTAAAACATAAAAACTAACTAAAATTCATATAAATCACCTAGAGTTGATGATATTAACATGG
TTCCTTGGTTGTCAAGTAAATCAAATGATTTCTTCCATCTGAGTAAAGAGTAAAGCCTGAGTAAAGAGTAAAAAGATGACTTCTCAAACA
TATCCAGAAATTTGTAAACAGTACACTCATATCTTTTAGTTTAAGAAGTGGTCTTAAAATATATAAATTTGTTTTTCCACCTATGTTTAA
TATGCCCAAATTTAAAGGGAGAGCTAAAAGACAGCCTACAAATAAATATAGCTATGAAATAAAATTATAGCACTTTACTAAAAAAGGGAT
GTAATAATGTTATTTAACGAAGTATTTTATATATGACTTGCCACTATTCTATACATAAAATTTTTTTTCTTAATTCTTTCCTGTGTTAAC
TAGGGTTATTTTCTATTTAAGGTAATCCTGCTGGAGAACAGATGCTATCCAATATTTATTACAACACATGAGTTGTGTTGTTTCACAATA
CTGAATTTCTTAGGTGAGGTATTTTATTTAAAAAGGAGGGGGAAAACTCCTATATTTTCTTGACTTCAAACCTGTGGGGCCAGGGGATAT
AGATTGAAATGCTCCGTATTTAGTCTTGGGGATCAGGCTTGTTTAGTACAATACCATGGTTTTAGAAGTCTGTACTAGGAACATTTTTAA
AATACATTTTTTATATTTCAGATGTAATGCAGTGCACTTTTATTTGAACAATAAAAAAACCCATAACTTTTTGAGACCATGAAGGTCTTT
TATTTTTTAATTTTGAAAATATGTGGTATGTGTATATGCAGACTACATCATTGTTTTAAGAAATGATTTAACTCTTGGACATTACACTTG
GGTTAGTTCACACCTTAAATCCCCAAGTAGTTAATATCTCAATTATTGTATAATCAGTTTATACCATCCATTCCCAACAAAATTCCACAT
TTCATGCCTTTTCAACATACATTTCAACATAATCAACATATTTACAAACACTGACTTCACTGTTTATAAAGAAGAAATTTCCCCTCCTAT
TTCCCATTACTGAAAAGTCAAGTCATTTTTATTGATACATGAAAATTAATTTTTTTGTAAATGACTACGTATAGTCATTTTTCTCCTTTG
GAAAAGGTAAATAGCTTATTAACTAATCCTGTCTTGTTCTTCACAAAAATAATAGTCCATCCGTGTTTTGACTCAAATAACCTAAATACA
CATTTTGTAAAAATTTTGTACCCTATATTACTTATTTTTAAAACAGTACAGTGTTAGACTAAACAGGAAAACTCAAAGTTATAAAATCTC

>In-frame_ENST00000397906_ENST00000358602_TCGA-AZ-6598-11A_TTC28_chr22_29025539_-_ANKRD17_chr4_73968264_length(amino acids)=1279AA_start in transcript=94_stop in transcript=3933
MAGPLARGGRGPGPVGMEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDF
HTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEA
KNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYS
QPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTS
NSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIIT
IRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHK
TIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNS
SGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPS
SPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVR
MTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTL
STQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQR
PAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAP
SSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVF
SQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQT

--------------------------------------------------------------
>In-frame_ENST00000397906_ENST00000509867_TCGA-AZ-6598-11A_TTC28_chr22_29025539_-_ANKRD17_chr4_73968264_length(transcript)=4479nt_BP=523nt
GGGGGCGCGCGCGCGGTTTGGGGGCAGTGAGGGGCGCCGCGGCGGCGCGCAGCACGGCGGGAACATGGCGCGCGGAACCGGCGCGCGCGC
CTAGCTGGCGGGACCGTTAGCTCGAGGCGGACGCGGCCCGGGCCCCGTGGGGATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCA
AGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCGGCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTAT
TGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAGAAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGA
TTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAGAACTGCATCTTATACAGCAATAGATCTGCAGCCTACAT
GAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTTCTCAATCCCAAGTGGCCAAAGTTAAGGGAAGAAAGTCG
GAGGCTGGCTTTGGCTGCGAAAAGAGAAAAAAGAAAAGAGAAGAGAAGGAAGAAAAAGGAAGAACAAAGAAGGAAACTAGAAGAAATTGA
AGCCAAAAATAAAGAGAACTTTGAACTCCAAGCTGCTCAAGAAAAAGAAAAGCTTAAAGTTGAAGATGAGCCTGAAGTCTTGACAGAACC
TCCAAGTGCCACAACCACTACTACCATAGGTATATCTGCAACCTGGACAACTTTGGCAGGTTCTCATGGTAAAAGAAATAATACCATAAC
TACAACCAGTTCAAAGAGGAAAAACAGGAAAAATAAAATTACTCCAGAAAACGTTCAAATTATATTTGATGATCCACTACCAATTTCATA
CAGTCAGCCAGAGAAGGTGAATGGAGAGTCCAAGAGCAGCAGTACCAGCGAGAGTGGGGACAGTGATAACATGAGGATTTCCAGCTGCAG
CGATGAAAGTAGTAACAGCAACAGCAGTCGTAAGAGTGACAATCATTCACCAGCTGTGGTCACTACCACTGTGAGCAGCAAAAAGCAGCC
ATCAGTTCTTGTTACATTTCCAAAGGAAGAGAGAAAATCTGTTTCTGGCAAGGCTTCAATAAAATTGTCAGAAACTATCAGTGAAGGGAC
CAGTAATTCTCTATCTACTTGTACAAAATCTGGTCCATCTCCCCTTTCTTCTCCAAATGGGAAGTTAACAGTAGCAAGTCCTAAGCGTGG
GCAAAAGAGGGAAGAAGGATGGAAAGAAGTTGTAAGAAGGTCAAAGAAAGTATCTGTTCCATCAACTGTGATATCCAGAGTGATTGGAAG
AGGAGGCTGTAATATCAATGCTATTCGGGAGTTTACTGGTGCACACATAGATATTGATAAACAGAAAGACAAGACTGGAGACCGGATAAT
CACTATAAGGGGTGGCACTGAATCAACAAGACAAGCAACTCAATTGATTAATGCTTTGATCAAGGATCCAGACAAAGAAATTGATGAACT
TATTCCAAAGAATCGTTTGAAAAGCTCCTCAGCAAATTCCAAAATAGGGTCATCAGCACCTACCACCACTGCTGCTAACACTTCCTTAAT
GGGAATTAAAATGACAACTGTAGCTCTGTCATCAACATCTCAAACTGCCACAGCACTCACTGTGCCTGCAATTTCTTCTGCATCCACTCA
CAAAACCATTAAGAACCCAGTGAATAATGTGAGGCCTGGTTTTCCAGTTTCTCTTCCATTAGCATATCCTCCTCCACAGTTTGCACATGC
TTTGCTTGCTGCTCAGACTTTCCAGCAGATCCGTCCACCAAGGTTGCCCATGACCCACTTTGGAGGTACTTTTCCACCAGCTCAATCCAC
TTGGGGTCCGTTTCCTGTCAGGCCTTTGAGCCCTGCCAGAGCTACTAACTCGCCTAAGCCTCACATGGTGCCTCGCCATAGCAATCAGAA
TAGCAGTGGTTCTCAGGTGAATTCAGCAGGTTCTTTAACTTCAAGCCCAACAACTACAACCAGTTCATCAGCTTCAACGGTGCCTGGTAC
ATCTACAAATGGCAGTCCAAGTTCACCTTCTGTCCGAAGGCAGCTTTTTGTCACAGTTGTGAAGACATCCAATGCCACCACAACAACAGT
CACAACCACGGCAAGCAACAACAACACTGCACCCACAAATGCCACATATCCTATGCCTACTGCCAAAGAACACTATCCAGTATCATCCCC
ATCTTCCCCATCACCACCAGCCCAGCCAGGAGGGGTTTCTAGAAACAGCCCTTTGGATTGTGGATCAGCATCTCCAAATAAAGTGGCATC
TTCCTCCGAACAGGAAGCAGGTAGTCCACCAGTAGTAGAAACAACAAACACTAGACCTCCAAACAGCAGCAGTTCTTCTGGGAGTTCATC
AGCTCATTCTAATCAGCAACAACCTCCGGGATCTGTTTCTCAGGAACCAAGACCACCTCTTCAGCAGTCTCAGGTTCCTCCCCCGGAAGT
TAGAATGACTGTTCCTCCTTTAGCAACAAGTTCTGCTCCAGTGGCGGTGCCTTCTACTGCCCCAGTGACTTACCCTATGCCTCAGACACC
AATGGGATGCCCCCAGCCTACTCCTAAAATGGAAACCCCTGCTATTAGACCACCCCCTCATGGCACAACTGCCCCTCACAAGAATTCAGC
TTCAGTGCAAAATTCATCTGTTGCAGTCCTCAGTGTCAATCACATTAAAAGACCTCACAGTGTTCCCTCTTCTGTCCAGCTACCTTCGAC
CTTAAGTACACAAAGTGCTTGTCAGAATTCAGTACATCCAGCAAATAAGCCTATTGCTCCCAATTTCAGTGCCCCCTTACCATTTGGGCC
CTTTAGCACATTGTTTGAAAACAGCCCTACTTCTGCTCATGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTAT
GCTATCAGGAAAATCCTCATATTTGCCAAATTCAGATCCTTTACATCAGTCTGATACTTCCAAAGCTCCAGGTTTTAGACCACCATTACA
GAGACCTGCTCCAAGTCCCTCAGGTATTGTCAATATGGACTCGCCATATGGTTCTGTAACACCTTCTTCAACACATTTGGGAAACTTTGC
TTCAAACATTTCAGGAGGTCAGATGTACGGACCTGGGGCACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTTAACAGACAACATTTTTC
CCCGCTTAGTTTGTTGACTCCGTGTTCATCAGCATCAAATGATTCTTCTGCACAGTCAGTATCCTCGGGAGTTCGTGCACCATCTCCTGC
CCCATCATCAGTACCGTTAGGGTCAGAAAAGCCCAGCAATGTGTCTCAGGACAGGAAAGTTCCAGTCCCTATTGGGACTGAACGTTCTGC
ACGTATCAGGCAAACTGGAACGTCAGCTCCATCTGTTATTGGGAGCAATTTGTCTACATCAGTAGGACATAGTGGCATCTGGTCCTTTGA
AGGGATTGGTGGCAATCAAGACAAAGTAGACTGGTGTAACCCTGGGATGGGAAATCCTATGATCCACAGACCGATGTCTGACCCAGGAGT
ATTTTCACAACATCAAGCAATGGAGCGAGATAGTACAGGAATTGTAACTCCTTCTGGTACATTCCATCAGCATGTTCCTGCAGGCTACAT
GGACTTTCCTAAAGTTGGGGGTATGCCTTTTTCTGTGTATGGGAATGCAATGATTCCTCCAGTAGCACCTATCCCTGATGGTGCTGGAGG
ACCCATATTTAATGGCCCTCATGCTGCAGACCCTTCTTGGAACTCACTGATAAAGATGGTTTCCAGCTCCACGGAAAATAATGGCCCTCA
AACGGTGTGGACTGGACCCTGGGCACCTCACATGAACAGTGTGCATATGAACCAGCTTGGCTGATGAGGATCAGCTTGTTAGCCTGCAGA
TTCCTTTTCATTTGGAGGAAATCACAAGTGGCCGAAAAAAAAAATTATGCTCCCAAATCATTCTACTGATGTGCTTGACTGAAGTGTGTA
GGCTTTTTGCAGAAGATCTTACTAACTGACCTATTTTCTGTGAACATTTGTGACTGCCCATTCCCCATCATCATCCGTTTTACCTTAGTT
AGCATTTTTCTTATCATTTTTCTTTTTTTCTTTCCCTCTTCCCCTTTGGACATAACTTTCTGTTGAAGCTGTTCTTTGGCTGGTTGGTTT
TAGTACTGTAAACTGCTTCTGAGCAAACACGGAAATTTAGCAAAATTATGTAAACTTGATCCTGAAGTTTTAGAATGGCAAATAAATGTA
CAATTGTTTACATAACAGAAAAGGCTAAGCAGAAAGTAAATTTCAATATGTCAGTATAGAGGCTCTACTTTATGTAGACTTAAATTAATG

>In-frame_ENST00000397906_ENST00000509867_TCGA-AZ-6598-11A_TTC28_chr22_29025539_-_ANKRD17_chr4_73968264_length(amino acids)=1279AA_start in transcript=94_stop in transcript=3933
MAGPLARGGRGPGPVGMEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDF
HTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEA
KNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYS
QPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTS
NSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIIT
IRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHK
TIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNS
SGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPS
SPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVR
MTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTL
STQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQR
PAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAP
SSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVF
SQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQT

--------------------------------------------------------------
>In-frame_ENST00000397906_ENST00000330838_TCGA-AZ-6598-11A_TTC28_chr22_29025539_-_ANKRD17_chr4_73968264_length(transcript)=4479nt_BP=523nt
GGGGGCGCGCGCGCGGTTTGGGGGCAGTGAGGGGCGCCGCGGCGGCGCGCAGCACGGCGGGAACATGGCGCGCGGAACCGGCGCGCGCGC
CTAGCTGGCGGGACCGTTAGCTCGAGGCGGACGCGGCCCGGGCCCCGTGGGGATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCA
AGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCGGCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTAT
TGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAGAAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGA
TTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAGAACTGCATCTTATACAGCAATAGATCTGCAGCCTACAT
GAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTTCTCAATCCCAAGTGGCCAAAGTTAAGGGAAGAAAGTCG
GAGGCTGGCTTTGGCTGCGAAAAGAGAAAAAAGAAAAGAGAAGAGAAGGAAGAAAAAGGAAGAACAAAGAAGGAAACTAGAAGAAATTGA
AGCCAAAAATAAAGAGAACTTTGAACTCCAAGCTGCTCAAGAAAAAGAAAAGCTTAAAGTTGAAGATGAGCCTGAAGTCTTGACAGAACC
TCCAAGTGCCACAACCACTACTACCATAGGTATATCTGCAACCTGGACAACTTTGGCAGGTTCTCATGGTAAAAGAAATAATACCATAAC
TACAACCAGTTCAAAGAGGAAAAACAGGAAAAATAAAATTACTCCAGAAAACGTTCAAATTATATTTGATGATCCACTACCAATTTCATA
CAGTCAGCCAGAGAAGGTGAATGGAGAGTCCAAGAGCAGCAGTACCAGCGAGAGTGGGGACAGTGATAACATGAGGATTTCCAGCTGCAG
CGATGAAAGTAGTAACAGCAACAGCAGTCGTAAGAGTGACAATCATTCACCAGCTGTGGTCACTACCACTGTGAGCAGCAAAAAGCAGCC
ATCAGTTCTTGTTACATTTCCAAAGGAAGAGAGAAAATCTGTTTCTGGCAAGGCTTCAATAAAATTGTCAGAAACTATCAGTGAAGGGAC
CAGTAATTCTCTATCTACTTGTACAAAATCTGGTCCATCTCCCCTTTCTTCTCCAAATGGGAAGTTAACAGTAGCAAGTCCTAAGCGTGG
GCAAAAGAGGGAAGAAGGATGGAAAGAAGTTGTAAGAAGGTCAAAGAAAGTATCTGTTCCATCAACTGTGATATCCAGAGTGATTGGAAG
AGGAGGCTGTAATATCAATGCTATTCGGGAGTTTACTGGTGCACACATAGATATTGATAAACAGAAAGACAAGACTGGAGACCGGATAAT
CACTATAAGGGGTGGCACTGAATCAACAAGACAAGCAACTCAATTGATTAATGCTTTGATCAAGGATCCAGACAAAGAAATTGATGAACT
TATTCCAAAGAATCGTTTGAAAAGCTCCTCAGCAAATTCCAAAATAGGGTCATCAGCACCTACCACCACTGCTGCTAACACTTCCTTAAT
GGGAATTAAAATGACAACTGTAGCTCTGTCATCAACATCTCAAACTGCCACAGCACTCACTGTGCCTGCAATTTCTTCTGCATCCACTCA
CAAAACCATTAAGAACCCAGTGAATAATGTGAGGCCTGGTTTTCCAGTTTCTCTTCCATTAGCATATCCTCCTCCACAGTTTGCACATGC
TTTGCTTGCTGCTCAGACTTTCCAGCAGATCCGTCCACCAAGGTTGCCCATGACCCACTTTGGAGGTACTTTTCCACCAGCTCAATCCAC
TTGGGGTCCGTTTCCTGTCAGGCCTTTGAGCCCTGCCAGAGCTACTAACTCGCCTAAGCCTCACATGGTGCCTCGCCATAGCAATCAGAA
TAGCAGTGGTTCTCAGGTGAATTCAGCAGGTTCTTTAACTTCAAGCCCAACAACTACAACCAGTTCATCAGCTTCAACGGTGCCTGGTAC
ATCTACAAATGGCAGTCCAAGTTCACCTTCTGTCCGAAGGCAGCTTTTTGTCACAGTTGTGAAGACATCCAATGCCACCACAACAACAGT
CACAACCACGGCAAGCAACAACAACACTGCACCCACAAATGCCACATATCCTATGCCTACTGCCAAAGAACACTATCCAGTATCATCCCC
ATCTTCCCCATCACCACCAGCCCAGCCAGGAGGGGTTTCTAGAAACAGCCCTTTGGATTGTGGATCAGCATCTCCAAATAAAGTGGCATC
TTCCTCCGAACAGGAAGCAGGTAGTCCACCAGTAGTAGAAACAACAAACACTAGACCTCCAAACAGCAGCAGTTCTTCTGGGAGTTCATC
AGCTCATTCTAATCAGCAACAACCTCCGGGATCTGTTTCTCAGGAACCAAGACCACCTCTTCAGCAGTCTCAGGTTCCTCCCCCGGAAGT
TAGAATGACTGTTCCTCCTTTAGCAACAAGTTCTGCTCCAGTGGCGGTGCCTTCTACTGCCCCAGTGACTTACCCTATGCCTCAGACACC
AATGGGATGCCCCCAGCCTACTCCTAAAATGGAAACCCCTGCTATTAGACCACCCCCTCATGGCACAACTGCCCCTCACAAGAATTCAGC
TTCAGTGCAAAATTCATCTGTTGCAGTCCTCAGTGTCAATCACATTAAAAGACCTCACAGTGTTCCCTCTTCTGTCCAGCTACCTTCGAC
CTTAAGTACACAAAGTGCTTGTCAGAATTCAGTACATCCAGCAAATAAGCCTATTGCTCCCAATTTCAGTGCCCCCTTACCATTTGGGCC
CTTTAGCACATTGTTTGAAAACAGCCCTACTTCTGCTCATGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTAT
GCTATCAGGAAAATCCTCATATTTGCCAAATTCAGATCCTTTACATCAGTCTGATACTTCCAAAGCTCCAGGTTTTAGACCACCATTACA
GAGACCTGCTCCAAGTCCCTCAGGTATTGTCAATATGGACTCGCCATATGGTTCTGTAACACCTTCTTCAACACATTTGGGAAACTTTGC
TTCAAACATTTCAGGAGGTCAGATGTACGGACCTGGGGCACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTTAACAGACAACATTTTTC
CCCGCTTAGTTTGTTGACTCCGTGTTCATCAGCATCAAATGATTCTTCTGCACAGTCAGTATCCTCGGGAGTTCGTGCACCATCTCCTGC
CCCATCATCAGTACCGTTAGGGTCAGAAAAGCCCAGCAATGTGTCTCAGGACAGGAAAGTTCCAGTCCCTATTGGGACTGAACGTTCTGC
ACGTATCAGGCAAACTGGAACGTCAGCTCCATCTGTTATTGGGAGCAATTTGTCTACATCAGTAGGACATAGTGGCATCTGGTCCTTTGA
AGGGATTGGTGGCAATCAAGACAAAGTAGACTGGTGTAACCCTGGGATGGGAAATCCTATGATCCACAGACCGATGTCTGACCCAGGAGT
ATTTTCACAACATCAAGCAATGGAGCGAGATAGTACAGGAATTGTAACTCCTTCTGGTACATTCCATCAGCATGTTCCTGCAGGCTACAT
GGACTTTCCTAAAGTTGGGGGTATGCCTTTTTCTGTGTATGGGAATGCAATGATTCCTCCAGTAGCACCTATCCCTGATGGTGCTGGAGG
ACCCATATTTAATGGCCCTCATGCTGCAGACCCTTCTTGGAACTCACTGATAAAGATGGTTTCCAGCTCCACGGAAAATAATGGCCCTCA
AACGGTGTGGACTGGACCCTGGGCACCTCACATGAACAGTGTGCATATGAACCAGCTTGGCTGATGAGGATCAGCTTGTTAGCCTGCAGA
TTCCTTTTCATTTGGAGGAAATCACAAGTGGCCGAAAAAAAAAATTATGCTCCCAAATCATTCTACTGATGTGCTTGACTGAAGTGTGTA
GGCTTTTTGCAGAAGATCTTACTAACTGACCTATTTTCTGTGAACATTTGTGACTGCCCATTCCCCATCATCATCCGTTTTACCTTAGTT
AGCATTTTTCTTATCATTTTTCTTTTTTTCTTTCCCTCTTCCCCTTTGGACATAACTTTCTGTTGAAGCTGTTCTTTGGCTGGTTGGTTT
TAGTACTGTAAACTGCTTCTGAGCAAACACGGAAATTTAGCAAAATTATGTAAACTTGATCCTGAAGTTTTAGAATGGCAAATAAATGTA
CAATTGTTTACATAACAGAAAAGGCTAAGCAGAAAGTAAATTTCAATATGTCAGTATAGAGGCTCTACTTTATGTAGACTTAAATTAATG

>In-frame_ENST00000397906_ENST00000330838_TCGA-AZ-6598-11A_TTC28_chr22_29025539_-_ANKRD17_chr4_73968264_length(amino acids)=1279AA_start in transcript=94_stop in transcript=3933
MAGPLARGGRGPGPVGMEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDF
HTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEA
KNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYS
QPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTS
NSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIIT
IRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHK
TIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNS
SGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPS
SPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVR
MTVPPLATSSAPVAVPSTAPVTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPSTL
STQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQR
PAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAP
SSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVF
SQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQT

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Fusion Gene PPI Analysis for TTC28-ANKRD17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTC28-ANKRD17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTC28-ANKRD17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTTC28C2931456Prostate cancer, familial1CTD_human
HgeneTTC28C4722327PROSTATE CANCER, HEREDITARY, 11CTD_human