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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTC39A-PHGDH (FusionGDB2 ID:94399)

Fusion Gene Summary for TTC39A-PHGDH

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC39A-PHGDH
Fusion gene ID: 94399
HgeneTgene
Gene symbol

TTC39A

PHGDH

Gene ID

22996

26227

Gene nametetratricopeptide repeat domain 39Aphosphoglycerate dehydrogenase
SynonymsC1orf34|DEME-63-PGDH|3PGDH|HEL-S-113|NLS|NLS1|PDG|PGAD|PGD|PGDH|PHGDHD|SERA
Cytomap

1p32.3

1p12

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 39ATPR repeat protein 39Adifferentially expressed in MCF7 with estradiol protein 6testicular tissue protein Li 213D-3-phosphoglycerate dehydrogenase2-oxoglutarate reductase3-phosphoglycerate dehydrogenaseepididymis secretory protein Li 113malate dehydrogenase
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000447632, ENST00000413473, 
ENST00000262675, ENST00000451380, 
ENST00000371750, ENST00000371747, 
ENST00000262676, ENST00000530004, 
ENST00000534098, 		ENST00000369409, 
ENST00000369407, ENST00000482968, 
Fusion gene scores* DoF score5 X 6 X 4=12015 X 10 X 8=1200
# samples 716
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1200*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTC39A [Title/Abstract] AND PHGDH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTC39A(51787393)-PHGDH(120263793), # samples:2
Anticipated loss of major functional domain due to fusion event.TTC39A-PHGDH seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TTC39A-PHGDH seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TTC39A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PHGDH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-6972-01ATTC39Achr1

51787393

-PHGDHchr1

120263793

+
ChimerDB4LUADTCGA-55-6972-01ATTC39Achr1

51787393

-PHGDHchr1

120263793

+


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Fusion Gene ORF analysis for TTC39A-PHGDH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000447632ENST00000369409TTC39Achr1

51787393

-PHGDHchr1

120263793

+
In-frameENST00000447632ENST00000369407TTC39Achr1

51787393

-PHGDHchr1

120263793

+
5CDS-intronENST00000447632ENST00000482968TTC39Achr1

51787393

-PHGDHchr1

120263793

+
Frame-shiftENST00000413473ENST00000369409TTC39Achr1

51787393

-PHGDHchr1

120263793

+
In-frameENST00000413473ENST00000369407TTC39Achr1

51787393

-PHGDHchr1

120263793

+
5CDS-intronENST00000413473ENST00000482968TTC39Achr1

51787393

-PHGDHchr1

120263793

+
In-frameENST00000262675ENST00000369409TTC39Achr1

51787393

-PHGDHchr1

120263793

+
Frame-shiftENST00000262675ENST00000369407TTC39Achr1

51787393

-PHGDHchr1

120263793

+
5CDS-intronENST00000262675ENST00000482968TTC39Achr1

51787393

-PHGDHchr1

120263793

+
Frame-shiftENST00000451380ENST00000369409TTC39Achr1

51787393

-PHGDHchr1

120263793

+
In-frameENST00000451380ENST00000369407TTC39Achr1

51787393

-PHGDHchr1

120263793

+
5CDS-intronENST00000451380ENST00000482968TTC39Achr1

51787393

-PHGDHchr1

120263793

+
Frame-shiftENST00000371750ENST00000369409TTC39Achr1

51787393

-PHGDHchr1

120263793

+
In-frameENST00000371750ENST00000369407TTC39Achr1

51787393

-PHGDHchr1

120263793

+
5CDS-intronENST00000371750ENST00000482968TTC39Achr1

51787393

-PHGDHchr1

120263793

+
Frame-shiftENST00000371747ENST00000369409TTC39Achr1

51787393

-PHGDHchr1

120263793

+
In-frameENST00000371747ENST00000369407TTC39Achr1

51787393

-PHGDHchr1

120263793

+
5CDS-intronENST00000371747ENST00000482968TTC39Achr1

51787393

-PHGDHchr1

120263793

+
Frame-shiftENST00000262676ENST00000369409TTC39Achr1

51787393

-PHGDHchr1

120263793

+
In-frameENST00000262676ENST00000369407TTC39Achr1

51787393

-PHGDHchr1

120263793

+
5CDS-intronENST00000262676ENST00000482968TTC39Achr1

51787393

-PHGDHchr1

120263793

+
intron-3CDSENST00000530004ENST00000369409TTC39Achr1

51787393

-PHGDHchr1

120263793

+
intron-3CDSENST00000530004ENST00000369407TTC39Achr1

51787393

-PHGDHchr1

120263793

+
intron-intronENST00000530004ENST00000482968TTC39Achr1

51787393

-PHGDHchr1

120263793

+
intron-3CDSENST00000534098ENST00000369409TTC39Achr1

51787393

-PHGDHchr1

120263793

+
intron-3CDSENST00000534098ENST00000369407TTC39Achr1

51787393

-PHGDHchr1

120263793

+
intron-intronENST00000534098ENST00000482968TTC39Achr1

51787393

-PHGDHchr1

120263793

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000447632TTC39Achr151787393-ENST00000369407PHGDHchr1120263793+18341983111660449
ENST00000413473TTC39Achr151787393-ENST00000369407PHGDHchr1120263793+18672313441693449
ENST00000262675TTC39Achr151787393-ENST00000369409PHGDHchr1120263793+18792403541703449
ENST00000451380TTC39Achr151787393-ENST00000369407PHGDHchr1120263793+18652293421691449
ENST00000371750TTC39Achr151787393-ENST00000369407PHGDHchr1120263793+18822463591708449
ENST00000371747TTC39Achr151787393-ENST00000369407PHGDHchr1120263793+18672313441693449
ENST00000262676TTC39Achr151787393-ENST00000369407PHGDHchr1120263793+19342984111760449

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000447632ENST00000369407TTC39Achr151787393-PHGDHchr1120263793+0.026221440.9737786
ENST00000413473ENST00000369407TTC39Achr151787393-PHGDHchr1120263793+0.0292782370.9707218
ENST00000262675ENST00000369409TTC39Achr151787393-PHGDHchr1120263793+0.020544860.9794551
ENST00000451380ENST00000369407TTC39Achr151787393-PHGDHchr1120263793+0.031449780.96855026
ENST00000371750ENST00000369407TTC39Achr151787393-PHGDHchr1120263793+0.0235675950.97643244
ENST00000371747ENST00000369407TTC39Achr151787393-PHGDHchr1120263793+0.0315734450.9684266
ENST00000262676ENST00000369407TTC39Achr151787393-PHGDHchr1120263793+0.0256752150.97432476

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Fusion Genomic Features for TTC39A-PHGDH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TTC39Achr151787392-PHGDHchr1120263792+2.96E-091
TTC39Achr151787392-PHGDHchr1120263792+2.96E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TTC39A-PHGDH


check button Go to

FGviewer for the breakpoints of chr1:51787393-chr1:120263793

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePHGDHchr1:51787393chr1:120263793ENST00000369409012155_15646.0534.0Nucleotide bindingNAD
TgenePHGDHchr1:51787393chr1:120263793ENST00000369409012234_23646.0534.0Nucleotide bindingNAD
TgenePHGDHchr1:51787393chr1:120263793ENST00000369409012283_28646.0534.0Nucleotide bindingNAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTC39Achr1:51787393chr1:120263793ENST00000262676-211315_34845.666666666666664421.0RepeatNote=TPR 1
HgeneTTC39Achr1:51787393chr1:120263793ENST00000262676-211505_53845.666666666666664421.0RepeatNote=TPR 2
HgeneTTC39Achr1:51787393chr1:120263793ENST00000262676-211546_57945.666666666666664421.0RepeatNote=TPR 3
HgeneTTC39Achr1:51787393chr1:120263793ENST00000413473-218315_34852.666666666666664582.0RepeatNote=TPR 1
HgeneTTC39Achr1:51787393chr1:120263793ENST00000413473-218505_53852.666666666666664582.0RepeatNote=TPR 2
HgeneTTC39Achr1:51787393chr1:120263793ENST00000413473-218546_57952.666666666666664582.0RepeatNote=TPR 3
HgeneTTC39Achr1:51787393chr1:120263793ENST00000447632-218315_34849.666666666666664614.0RepeatNote=TPR 1
HgeneTTC39Achr1:51787393chr1:120263793ENST00000447632-218505_53849.666666666666664614.0RepeatNote=TPR 2
HgeneTTC39Achr1:51787393chr1:120263793ENST00000447632-218546_57949.666666666666664614.0RepeatNote=TPR 3
HgeneTTC39Achr1:51787393chr1:120263793ENST00000451380-218315_34848.666666666666664578.0RepeatNote=TPR 1
HgeneTTC39Achr1:51787393chr1:120263793ENST00000451380-218505_53848.666666666666664578.0RepeatNote=TPR 2
HgeneTTC39Achr1:51787393chr1:120263793ENST00000451380-218546_57948.666666666666664578.0RepeatNote=TPR 3
HgeneTTC39Achr1:51787393chr1:120263793ENST00000530004-17315_3480222.0RepeatNote=TPR 1
HgeneTTC39Achr1:51787393chr1:120263793ENST00000530004-17505_5380222.0RepeatNote=TPR 2
HgeneTTC39Achr1:51787393chr1:120263793ENST00000530004-17546_5790222.0RepeatNote=TPR 3


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Fusion Gene Sequence for TTC39A-PHGDH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000447632_ENST00000369407_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(transcript)=1834nt_BP=198nt
GTGGGATTTAGTGGCTGGGCTGCACCCCCTGGGGGGGCAGCAGAGCCCAATGGGCCAGAAGGGCCACAAAGACTCCCTTTACCCTTGTGG
AGGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGACCAGTGCATGACCGCCCTGGACCTCTTCCTCACCAACCAGTTCTCAGAAGCACT
CAGCTACCTCAAGCCCAGACTGTGAAGGCCTTATTGTTCGCTCTGCCACCAAGGTGACCGCTGATGTCATCAACGCAGCTGAGAAACTCC
AGGTGGTGGGCAGGGCTGGCACAGGTGTGGACAATGTGGATCTGGAGGCCGCAACAAGGAAGGGCATCTTGGTTATGAACACCCCCAATG
GGAACAGCCTCAGTGCCGCAGAACTCACTTGTGGAATGATCATGTGCCTGGCCAGGCAGATTCCCCAGGCGACGGCTTCGATGAAGGACG
GCAAATGGGAGCGGAAGAAGTTCATGGGAACAGAGCTGAATGGAAAGACCCTGGGAATTCTTGGCCTGGGCAGGATTGGGAGAGAGGTAG
CTACCCGGATGCAGTCCTTTGGGATGAAGACTATAGGGTATGACCCCATCATTTCCCCAGAGGTCTCGGCCTCCTTTGGTGTTCAGCAGC
TGCCCCTGGAGGAGATCTGGCCTCTCTGTGATTTCATCACTGTGCACACTCCTCTCCTGCCCTCCACGACAGGCTTGCTGAATGACAACA
CCTTTGCCCAGTGCAAGAAGGGGGTGCGTGTGGTGAACTGTGCCCGTGGAGGGATCGTGGACGAAGGCGCCCTGCTCCGGGCCCTGCAGT
CTGGCCAGTGTGCCGGGGCTGCACTGGACGTGTTTACGGAAGAGCCGCCACGGGACCGGGCCTTGGTGGACCATGAGAATGTCATCAGCT
GTCCCCACCTGGGTGCCAGCACCAAGGAGGCTCAGAGCCGCTGTGGGGAGGAAATTGCTGTTCAGTTCGTGGACATGGTGAAGGGGAAAT
CTCTCACGGGGGTTGTGAATGCCCAGGCCCTTACCAGTGCCTTCTCTCCACACACCAAGCCTTGGATTGGTCTGGCAGAAGCTCTGGGGA
CACTGATGCGAGCCTGGGCTGGGTCCCCCAAAGGGACCATCCAGGTGATAACACAGGGAACATCCCTGAAGAATGCTGGGAACTGCCTAA
GCCCCGCAGTCATTGTCGGCCTCCTGAAAGAGGCTTCCAAGCAGGCGGATGTGAACTTGGTGAACGCTAAGCTGCTGGTGAAAGAGGCTG
GCCTCAATGTCACCACCTCCCACAGCCCTGCTGCACCAGGGGAGCAAGGCTTCGGGGAATGCCTCCTGGCCGTGGCCCTGGCAGGCGCCC
CTTACCAGGCTGTGGGCTTGGTCCAAGGCACTACGCCTGTACTGCAGGGGCTCAATGGAGCTGTCTTCAGGCCAGAAGTGCCTCTCCGCA
GGGACCTGCCCCTGCTCCTATTCCGGACTCAGACCTCTGACCCTGCAATGCTGCCTACCATGATTGGCCTCCTGGCAGAGGCAGGCGTGC
GGCTGCTGTCCTACCAGACTTCACTGGTGTCAGATGGGGAGACCTGGCACGTCATGGGCATCTCCTCCTTGCTGCCCAGCCTGGAAGCGT
GGAAGCAGCATGTGACTGAAGCCTTCCAGTTCCACTTCTAACCTTGGAGCTCACTGGTCCCTGCCTCTGGGGCTTTTCTGAAGAAACCCA
CCCACTGTGATCAATAGGGAGAGAAAATCCACATTCTTGGGCTGAACGCGGGCCTCTGACACTGCTTACACTGCACTCTGACCCTGTAGT

>In-frame_ENST00000447632_ENST00000369407_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(amino acids)=449AA_start in transcript=311_stop in transcript=1660
MEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGY
DPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTE
EPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTI
QVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGAPYQAVGLVQGTTPV

--------------------------------------------------------------
>In-frame_ENST00000413473_ENST00000369407_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(transcript)=1867nt_BP=231nt
ACTGTAGCCTCCACGGCCGCCGCCGCCGCCGCGAGGGGCCGCCCGCGGCCCCGTCCGAGCCCGGCCCGCGCCCATGGCCTTTCTGACCAC
CTGGAAGGAGGCGGCCTCCGGGAAAAGCGACCGCAGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGACCAGTGCATGACCGCCCTGGA
CCTCTTCCTCACCAACCAGTTCTCAGAAGCACTCAGCTACCTCAAGCCCAGACTGTGAAGGCCTTATTGTTCGCTCTGCCACCAAGGTGA
CCGCTGATGTCATCAACGCAGCTGAGAAACTCCAGGTGGTGGGCAGGGCTGGCACAGGTGTGGACAATGTGGATCTGGAGGCCGCAACAA
GGAAGGGCATCTTGGTTATGAACACCCCCAATGGGAACAGCCTCAGTGCCGCAGAACTCACTTGTGGAATGATCATGTGCCTGGCCAGGC
AGATTCCCCAGGCGACGGCTTCGATGAAGGACGGCAAATGGGAGCGGAAGAAGTTCATGGGAACAGAGCTGAATGGAAAGACCCTGGGAA
TTCTTGGCCTGGGCAGGATTGGGAGAGAGGTAGCTACCCGGATGCAGTCCTTTGGGATGAAGACTATAGGGTATGACCCCATCATTTCCC
CAGAGGTCTCGGCCTCCTTTGGTGTTCAGCAGCTGCCCCTGGAGGAGATCTGGCCTCTCTGTGATTTCATCACTGTGCACACTCCTCTCC
TGCCCTCCACGACAGGCTTGCTGAATGACAACACCTTTGCCCAGTGCAAGAAGGGGGTGCGTGTGGTGAACTGTGCCCGTGGAGGGATCG
TGGACGAAGGCGCCCTGCTCCGGGCCCTGCAGTCTGGCCAGTGTGCCGGGGCTGCACTGGACGTGTTTACGGAAGAGCCGCCACGGGACC
GGGCCTTGGTGGACCATGAGAATGTCATCAGCTGTCCCCACCTGGGTGCCAGCACCAAGGAGGCTCAGAGCCGCTGTGGGGAGGAAATTG
CTGTTCAGTTCGTGGACATGGTGAAGGGGAAATCTCTCACGGGGGTTGTGAATGCCCAGGCCCTTACCAGTGCCTTCTCTCCACACACCA
AGCCTTGGATTGGTCTGGCAGAAGCTCTGGGGACACTGATGCGAGCCTGGGCTGGGTCCCCCAAAGGGACCATCCAGGTGATAACACAGG
GAACATCCCTGAAGAATGCTGGGAACTGCCTAAGCCCCGCAGTCATTGTCGGCCTCCTGAAAGAGGCTTCCAAGCAGGCGGATGTGAACT
TGGTGAACGCTAAGCTGCTGGTGAAAGAGGCTGGCCTCAATGTCACCACCTCCCACAGCCCTGCTGCACCAGGGGAGCAAGGCTTCGGGG
AATGCCTCCTGGCCGTGGCCCTGGCAGGCGCCCCTTACCAGGCTGTGGGCTTGGTCCAAGGCACTACGCCTGTACTGCAGGGGCTCAATG
GAGCTGTCTTCAGGCCAGAAGTGCCTCTCCGCAGGGACCTGCCCCTGCTCCTATTCCGGACTCAGACCTCTGACCCTGCAATGCTGCCTA
CCATGATTGGCCTCCTGGCAGAGGCAGGCGTGCGGCTGCTGTCCTACCAGACTTCACTGGTGTCAGATGGGGAGACCTGGCACGTCATGG
GCATCTCCTCCTTGCTGCCCAGCCTGGAAGCGTGGAAGCAGCATGTGACTGAAGCCTTCCAGTTCCACTTCTAACCTTGGAGCTCACTGG
TCCCTGCCTCTGGGGCTTTTCTGAAGAAACCCACCCACTGTGATCAATAGGGAGAGAAAATCCACATTCTTGGGCTGAACGCGGGCCTCT

>In-frame_ENST00000413473_ENST00000369407_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(amino acids)=449AA_start in transcript=344_stop in transcript=1693
MEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGY
DPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTE
EPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTI
QVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGAPYQAVGLVQGTTPV

--------------------------------------------------------------
>In-frame_ENST00000262675_ENST00000369409_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(transcript)=1879nt_BP=240nt
CACGTTCAGAGCAGCCTTCCCCACCTGCCTCGTGGCGTTCACTCCTGTGGGGTGGGCCCTGTTACTCTCATCCCCATTACAGATGAGGAA
ACTGAGACACAGCACTTAAGTGACTTGTCATCGGTCACCCAGGAGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGACCAGTGCATGAC
CGCCCTGGACCTCTTCCTCACCAACCAGTTCTCAGAAGCACTCAGCTACCTCAAGCCCAGGACTGTGAAGGCCTTATTGTTCGCTCTGCC
ACCAAGGTGACCGCTGATGTCATCAACGCAGCTGAGAAACTCCAGGTGGTGGGCAGGGCTGGCACAGGTGTGGACAATGTGGATCTGGAG
GCCGCAACAAGGAAGGGCATCTTGGTTATGAACACCCCCAATGGGAACAGCCTCAGTGCCGCAGAACTCACTTGTGGAATGATCATGTGC
CTGGCCAGGCAGATTCCCCAGGCGACGGCTTCGATGAAGGACGGCAAATGGGAGCGGAAGAAGTTCATGGGAACAGAGCTGAATGGAAAG
ACCCTGGGAATTCTTGGCCTGGGCAGGATTGGGAGAGAGGTAGCTACCCGGATGCAGTCCTTTGGGATGAAGACTATAGGGTATGACCCC
ATCATTTCCCCAGAGGTCTCGGCCTCCTTTGGTGTTCAGCAGCTGCCCCTGGAGGAGATCTGGCCTCTCTGTGATTTCATCACTGTGCAC
ACTCCTCTCCTGCCCTCCACGACAGGCTTGCTGAATGACAACACCTTTGCCCAGTGCAAGAAGGGGGTGCGTGTGGTGAACTGTGCCCGT
GGAGGGATCGTGGACGAAGGCGCCCTGCTCCGGGCCCTGCAGTCTGGCCAGTGTGCCGGGGCTGCACTGGACGTGTTTACGGAAGAGCCG
CCACGGGACCGGGCCTTGGTGGACCATGAGAATGTCATCAGCTGTCCCCACCTGGGTGCCAGCACCAAGGAGGCTCAGAGCCGCTGTGGG
GAGGAAATTGCTGTTCAGTTCGTGGACATGGTGAAGGGGAAATCTCTCACGGGGGTTGTGAATGCCCAGGCCCTTACCAGTGCCTTCTCT
CCACACACCAAGCCTTGGATTGGTCTGGCAGAAGCTCTGGGGACACTGATGCGAGCCTGGGCTGGGTCCCCCAAAGGGACCATCCAGGTG
ATAACACAGGGAACATCCCTGAAGAATGCTGGGAACTGCCTAAGCCCCGCAGTCATTGTCGGCCTCCTGAAAGAGGCTTCCAAGCAGGCG
GATGTGAACTTGGTGAACGCTAAGCTGCTGGTGAAAGAGGCTGGCCTCAATGTCACCACCTCCCACAGCCCTGCTGCACCAGGGGAGCAA
GGCTTCGGGGAATGCCTCCTGGCCGTGGCCCTGGCAGGCGCCCCTTACCAGGCTGTGGGCTTGGTCCAAGGCACTACGCCTGTACTGCAG
GGGCTCAATGGAGCTGTCTTCAGGCCAGAAGTGCCTCTCCGCAGGGACCTGCCCCTGCTCCTATTCCGGACTCAGACCTCTGACCCTGCA
ATGCTGCCTACCATGATTGGCCTCCTGGCAGAGGCAGGCGTGCGGCTGCTGTCCTACCAGACTTCACTGGTGTCAGATGGGGAGACCTGG
CACGTCATGGGCATCTCCTCCTTGCTGCCCAGCCTGGAAGCGTGGAAGCAGCATGTGACTGAAGCCTTCCAGTTCCACTTCTAACCTTGG
AGCTCACTGGTCCCTGCCTCTGGGGCTTTTCTGAAGAAACCCACCCACTGTGATCAATAGGGAGAGAAAATCCACATTCTTGGGCTGAAC

>In-frame_ENST00000262675_ENST00000369409_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(amino acids)=449AA_start in transcript=354_stop in transcript=1703
MEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGY
DPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTE
EPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTI
QVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGAPYQAVGLVQGTTPV

--------------------------------------------------------------
>In-frame_ENST00000451380_ENST00000369407_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(transcript)=1865nt_BP=229nt
AGCGCCCGGCTCGGGGTTGCGGCGGCAGCACCTGGGCCGCGATTGGCGTCCGGCTGGGGCAGCGCCGCCCGCGCCCCTCGGCGATGACCT
CGGCTGGCGGCGCCCCAGGAGCCCTGCCCGCGGGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGACCAGTGCATGACCGCCCTGGACC
TCTTCCTCACCAACCAGTTCTCAGAAGCACTCAGCTACCTCAAGCCCAGACTGTGAAGGCCTTATTGTTCGCTCTGCCACCAAGGTGACC
GCTGATGTCATCAACGCAGCTGAGAAACTCCAGGTGGTGGGCAGGGCTGGCACAGGTGTGGACAATGTGGATCTGGAGGCCGCAACAAGG
AAGGGCATCTTGGTTATGAACACCCCCAATGGGAACAGCCTCAGTGCCGCAGAACTCACTTGTGGAATGATCATGTGCCTGGCCAGGCAG
ATTCCCCAGGCGACGGCTTCGATGAAGGACGGCAAATGGGAGCGGAAGAAGTTCATGGGAACAGAGCTGAATGGAAAGACCCTGGGAATT
CTTGGCCTGGGCAGGATTGGGAGAGAGGTAGCTACCCGGATGCAGTCCTTTGGGATGAAGACTATAGGGTATGACCCCATCATTTCCCCA
GAGGTCTCGGCCTCCTTTGGTGTTCAGCAGCTGCCCCTGGAGGAGATCTGGCCTCTCTGTGATTTCATCACTGTGCACACTCCTCTCCTG
CCCTCCACGACAGGCTTGCTGAATGACAACACCTTTGCCCAGTGCAAGAAGGGGGTGCGTGTGGTGAACTGTGCCCGTGGAGGGATCGTG
GACGAAGGCGCCCTGCTCCGGGCCCTGCAGTCTGGCCAGTGTGCCGGGGCTGCACTGGACGTGTTTACGGAAGAGCCGCCACGGGACCGG
GCCTTGGTGGACCATGAGAATGTCATCAGCTGTCCCCACCTGGGTGCCAGCACCAAGGAGGCTCAGAGCCGCTGTGGGGAGGAAATTGCT
GTTCAGTTCGTGGACATGGTGAAGGGGAAATCTCTCACGGGGGTTGTGAATGCCCAGGCCCTTACCAGTGCCTTCTCTCCACACACCAAG
CCTTGGATTGGTCTGGCAGAAGCTCTGGGGACACTGATGCGAGCCTGGGCTGGGTCCCCCAAAGGGACCATCCAGGTGATAACACAGGGA
ACATCCCTGAAGAATGCTGGGAACTGCCTAAGCCCCGCAGTCATTGTCGGCCTCCTGAAAGAGGCTTCCAAGCAGGCGGATGTGAACTTG
GTGAACGCTAAGCTGCTGGTGAAAGAGGCTGGCCTCAATGTCACCACCTCCCACAGCCCTGCTGCACCAGGGGAGCAAGGCTTCGGGGAA
TGCCTCCTGGCCGTGGCCCTGGCAGGCGCCCCTTACCAGGCTGTGGGCTTGGTCCAAGGCACTACGCCTGTACTGCAGGGGCTCAATGGA
GCTGTCTTCAGGCCAGAAGTGCCTCTCCGCAGGGACCTGCCCCTGCTCCTATTCCGGACTCAGACCTCTGACCCTGCAATGCTGCCTACC
ATGATTGGCCTCCTGGCAGAGGCAGGCGTGCGGCTGCTGTCCTACCAGACTTCACTGGTGTCAGATGGGGAGACCTGGCACGTCATGGGC
ATCTCCTCCTTGCTGCCCAGCCTGGAAGCGTGGAAGCAGCATGTGACTGAAGCCTTCCAGTTCCACTTCTAACCTTGGAGCTCACTGGTC
CCTGCCTCTGGGGCTTTTCTGAAGAAACCCACCCACTGTGATCAATAGGGAGAGAAAATCCACATTCTTGGGCTGAACGCGGGCCTCTGA

>In-frame_ENST00000451380_ENST00000369407_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(amino acids)=449AA_start in transcript=342_stop in transcript=1691
MEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGY
DPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTE
EPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTI
QVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGAPYQAVGLVQGTTPV

--------------------------------------------------------------
>In-frame_ENST00000371750_ENST00000369407_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(transcript)=1882nt_BP=246nt
CCTGGGGGAGGGAGGAGGCCTTGGAGAAGGAGGAGGGAAAAAGGGGCTGTGGGATTTAGTGGCTGGGCTGCACCCCCTGGGGGGGCAGCA
GAGCCCAATGGGCCAGAAGGGCCACAAAGACTCCCTTTACCCTTGTGGAGGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGACCAGTG
CATGACCGCCCTGGACCTCTTCCTCACCAACCAGTTCTCAGAAGCACTCAGCTACCTCAAGCCCAGACTGTGAAGGCCTTATTGTTCGCT
CTGCCACCAAGGTGACCGCTGATGTCATCAACGCAGCTGAGAAACTCCAGGTGGTGGGCAGGGCTGGCACAGGTGTGGACAATGTGGATC
TGGAGGCCGCAACAAGGAAGGGCATCTTGGTTATGAACACCCCCAATGGGAACAGCCTCAGTGCCGCAGAACTCACTTGTGGAATGATCA
TGTGCCTGGCCAGGCAGATTCCCCAGGCGACGGCTTCGATGAAGGACGGCAAATGGGAGCGGAAGAAGTTCATGGGAACAGAGCTGAATG
GAAAGACCCTGGGAATTCTTGGCCTGGGCAGGATTGGGAGAGAGGTAGCTACCCGGATGCAGTCCTTTGGGATGAAGACTATAGGGTATG
ACCCCATCATTTCCCCAGAGGTCTCGGCCTCCTTTGGTGTTCAGCAGCTGCCCCTGGAGGAGATCTGGCCTCTCTGTGATTTCATCACTG
TGCACACTCCTCTCCTGCCCTCCACGACAGGCTTGCTGAATGACAACACCTTTGCCCAGTGCAAGAAGGGGGTGCGTGTGGTGAACTGTG
CCCGTGGAGGGATCGTGGACGAAGGCGCCCTGCTCCGGGCCCTGCAGTCTGGCCAGTGTGCCGGGGCTGCACTGGACGTGTTTACGGAAG
AGCCGCCACGGGACCGGGCCTTGGTGGACCATGAGAATGTCATCAGCTGTCCCCACCTGGGTGCCAGCACCAAGGAGGCTCAGAGCCGCT
GTGGGGAGGAAATTGCTGTTCAGTTCGTGGACATGGTGAAGGGGAAATCTCTCACGGGGGTTGTGAATGCCCAGGCCCTTACCAGTGCCT
TCTCTCCACACACCAAGCCTTGGATTGGTCTGGCAGAAGCTCTGGGGACACTGATGCGAGCCTGGGCTGGGTCCCCCAAAGGGACCATCC
AGGTGATAACACAGGGAACATCCCTGAAGAATGCTGGGAACTGCCTAAGCCCCGCAGTCATTGTCGGCCTCCTGAAAGAGGCTTCCAAGC
AGGCGGATGTGAACTTGGTGAACGCTAAGCTGCTGGTGAAAGAGGCTGGCCTCAATGTCACCACCTCCCACAGCCCTGCTGCACCAGGGG
AGCAAGGCTTCGGGGAATGCCTCCTGGCCGTGGCCCTGGCAGGCGCCCCTTACCAGGCTGTGGGCTTGGTCCAAGGCACTACGCCTGTAC
TGCAGGGGCTCAATGGAGCTGTCTTCAGGCCAGAAGTGCCTCTCCGCAGGGACCTGCCCCTGCTCCTATTCCGGACTCAGACCTCTGACC
CTGCAATGCTGCCTACCATGATTGGCCTCCTGGCAGAGGCAGGCGTGCGGCTGCTGTCCTACCAGACTTCACTGGTGTCAGATGGGGAGA
CCTGGCACGTCATGGGCATCTCCTCCTTGCTGCCCAGCCTGGAAGCGTGGAAGCAGCATGTGACTGAAGCCTTCCAGTTCCACTTCTAAC
CTTGGAGCTCACTGGTCCCTGCCTCTGGGGCTTTTCTGAAGAAACCCACCCACTGTGATCAATAGGGAGAGAAAATCCACATTCTTGGGC

>In-frame_ENST00000371750_ENST00000369407_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(amino acids)=449AA_start in transcript=359_stop in transcript=1708
MEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGY
DPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTE
EPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTI
QVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGAPYQAVGLVQGTTPV

--------------------------------------------------------------
>In-frame_ENST00000371747_ENST00000369407_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(transcript)=1867nt_BP=231nt
ACAGCGCCCGGCTCGGGGTTGCGGCGGCAGCACCTGGGCCGCGATTGGCGTCCGGCTGGGGCAGCGCCGCCCGCGCCCCTCGGCGATGAC
CTCGGCTGGCGGCGCCCCAGGAGCCCTGCCCGCGGGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGACCAGTGCATGACCGCCCTGGA
CCTCTTCCTCACCAACCAGTTCTCAGAAGCACTCAGCTACCTCAAGCCCAGACTGTGAAGGCCTTATTGTTCGCTCTGCCACCAAGGTGA
CCGCTGATGTCATCAACGCAGCTGAGAAACTCCAGGTGGTGGGCAGGGCTGGCACAGGTGTGGACAATGTGGATCTGGAGGCCGCAACAA
GGAAGGGCATCTTGGTTATGAACACCCCCAATGGGAACAGCCTCAGTGCCGCAGAACTCACTTGTGGAATGATCATGTGCCTGGCCAGGC
AGATTCCCCAGGCGACGGCTTCGATGAAGGACGGCAAATGGGAGCGGAAGAAGTTCATGGGAACAGAGCTGAATGGAAAGACCCTGGGAA
TTCTTGGCCTGGGCAGGATTGGGAGAGAGGTAGCTACCCGGATGCAGTCCTTTGGGATGAAGACTATAGGGTATGACCCCATCATTTCCC
CAGAGGTCTCGGCCTCCTTTGGTGTTCAGCAGCTGCCCCTGGAGGAGATCTGGCCTCTCTGTGATTTCATCACTGTGCACACTCCTCTCC
TGCCCTCCACGACAGGCTTGCTGAATGACAACACCTTTGCCCAGTGCAAGAAGGGGGTGCGTGTGGTGAACTGTGCCCGTGGAGGGATCG
TGGACGAAGGCGCCCTGCTCCGGGCCCTGCAGTCTGGCCAGTGTGCCGGGGCTGCACTGGACGTGTTTACGGAAGAGCCGCCACGGGACC
GGGCCTTGGTGGACCATGAGAATGTCATCAGCTGTCCCCACCTGGGTGCCAGCACCAAGGAGGCTCAGAGCCGCTGTGGGGAGGAAATTG
CTGTTCAGTTCGTGGACATGGTGAAGGGGAAATCTCTCACGGGGGTTGTGAATGCCCAGGCCCTTACCAGTGCCTTCTCTCCACACACCA
AGCCTTGGATTGGTCTGGCAGAAGCTCTGGGGACACTGATGCGAGCCTGGGCTGGGTCCCCCAAAGGGACCATCCAGGTGATAACACAGG
GAACATCCCTGAAGAATGCTGGGAACTGCCTAAGCCCCGCAGTCATTGTCGGCCTCCTGAAAGAGGCTTCCAAGCAGGCGGATGTGAACT
TGGTGAACGCTAAGCTGCTGGTGAAAGAGGCTGGCCTCAATGTCACCACCTCCCACAGCCCTGCTGCACCAGGGGAGCAAGGCTTCGGGG
AATGCCTCCTGGCCGTGGCCCTGGCAGGCGCCCCTTACCAGGCTGTGGGCTTGGTCCAAGGCACTACGCCTGTACTGCAGGGGCTCAATG
GAGCTGTCTTCAGGCCAGAAGTGCCTCTCCGCAGGGACCTGCCCCTGCTCCTATTCCGGACTCAGACCTCTGACCCTGCAATGCTGCCTA
CCATGATTGGCCTCCTGGCAGAGGCAGGCGTGCGGCTGCTGTCCTACCAGACTTCACTGGTGTCAGATGGGGAGACCTGGCACGTCATGG
GCATCTCCTCCTTGCTGCCCAGCCTGGAAGCGTGGAAGCAGCATGTGACTGAAGCCTTCCAGTTCCACTTCTAACCTTGGAGCTCACTGG
TCCCTGCCTCTGGGGCTTTTCTGAAGAAACCCACCCACTGTGATCAATAGGGAGAGAAAATCCACATTCTTGGGCTGAACGCGGGCCTCT

>In-frame_ENST00000371747_ENST00000369407_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(amino acids)=449AA_start in transcript=344_stop in transcript=1693
MEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGY
DPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTE
EPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTI
QVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGAPYQAVGLVQGTTPV

--------------------------------------------------------------
>In-frame_ENST00000262676_ENST00000369407_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(transcript)=1934nt_BP=298nt
GTGCCAGAAGATCAGGTCAGGTGGAGACACCGCCTCAGGGCTCGGTGCACAGTGGACATTTGGGGAGCGTTGTGGGTGACCCCCACACAG
GCACTGGGAATGCAGGGGAGAGGGGGCCAAGGGGGAAAGGGGCCAGAGTGTTGGCTTTGGATTCAGGAGGGATGGATTCCAGTCCTAGCT
TGCCACTTATTAGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGACCAGTGCATGACCGCCCTGGACCTCTTCCTCACCAACCAGTTCT
CAGAAGCACTCAGCTACCTCAAGCCCAGACTGTGAAGGCCTTATTGTTCGCTCTGCCACCAAGGTGACCGCTGATGTCATCAACGCAGCT
GAGAAACTCCAGGTGGTGGGCAGGGCTGGCACAGGTGTGGACAATGTGGATCTGGAGGCCGCAACAAGGAAGGGCATCTTGGTTATGAAC
ACCCCCAATGGGAACAGCCTCAGTGCCGCAGAACTCACTTGTGGAATGATCATGTGCCTGGCCAGGCAGATTCCCCAGGCGACGGCTTCG
ATGAAGGACGGCAAATGGGAGCGGAAGAAGTTCATGGGAACAGAGCTGAATGGAAAGACCCTGGGAATTCTTGGCCTGGGCAGGATTGGG
AGAGAGGTAGCTACCCGGATGCAGTCCTTTGGGATGAAGACTATAGGGTATGACCCCATCATTTCCCCAGAGGTCTCGGCCTCCTTTGGT
GTTCAGCAGCTGCCCCTGGAGGAGATCTGGCCTCTCTGTGATTTCATCACTGTGCACACTCCTCTCCTGCCCTCCACGACAGGCTTGCTG
AATGACAACACCTTTGCCCAGTGCAAGAAGGGGGTGCGTGTGGTGAACTGTGCCCGTGGAGGGATCGTGGACGAAGGCGCCCTGCTCCGG
GCCCTGCAGTCTGGCCAGTGTGCCGGGGCTGCACTGGACGTGTTTACGGAAGAGCCGCCACGGGACCGGGCCTTGGTGGACCATGAGAAT
GTCATCAGCTGTCCCCACCTGGGTGCCAGCACCAAGGAGGCTCAGAGCCGCTGTGGGGAGGAAATTGCTGTTCAGTTCGTGGACATGGTG
AAGGGGAAATCTCTCACGGGGGTTGTGAATGCCCAGGCCCTTACCAGTGCCTTCTCTCCACACACCAAGCCTTGGATTGGTCTGGCAGAA
GCTCTGGGGACACTGATGCGAGCCTGGGCTGGGTCCCCCAAAGGGACCATCCAGGTGATAACACAGGGAACATCCCTGAAGAATGCTGGG
AACTGCCTAAGCCCCGCAGTCATTGTCGGCCTCCTGAAAGAGGCTTCCAAGCAGGCGGATGTGAACTTGGTGAACGCTAAGCTGCTGGTG
AAAGAGGCTGGCCTCAATGTCACCACCTCCCACAGCCCTGCTGCACCAGGGGAGCAAGGCTTCGGGGAATGCCTCCTGGCCGTGGCCCTG
GCAGGCGCCCCTTACCAGGCTGTGGGCTTGGTCCAAGGCACTACGCCTGTACTGCAGGGGCTCAATGGAGCTGTCTTCAGGCCAGAAGTG
CCTCTCCGCAGGGACCTGCCCCTGCTCCTATTCCGGACTCAGACCTCTGACCCTGCAATGCTGCCTACCATGATTGGCCTCCTGGCAGAG
GCAGGCGTGCGGCTGCTGTCCTACCAGACTTCACTGGTGTCAGATGGGGAGACCTGGCACGTCATGGGCATCTCCTCCTTGCTGCCCAGC
CTGGAAGCGTGGAAGCAGCATGTGACTGAAGCCTTCCAGTTCCACTTCTAACCTTGGAGCTCACTGGTCCCTGCCTCTGGGGCTTTTCTG
AAGAAACCCACCCACTGTGATCAATAGGGAGAGAAAATCCACATTCTTGGGCTGAACGCGGGCCTCTGACACTGCTTACACTGCACTCTG

>In-frame_ENST00000262676_ENST00000369407_TCGA-55-6972-01A_TTC39A_chr1_51787393_-_PHGDH_chr1_120263793_length(amino acids)=449AA_start in transcript=411_stop in transcript=1760
MEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGY
DPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTE
EPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTI
QVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGAPYQAVGLVQGTTPV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TTC39A-PHGDH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTC39A-PHGDH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTC39A-PHGDH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTTC39AC0023903Liver neoplasms1CTD_human
HgeneTTC39AC0345904Malignant neoplasm of liver1CTD_human
TgenePHGDHC1866174Phosphoglycerate Dehydrogenase Deficiency4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePHGDHC4551478NEU-LAXOVA SYNDROME 14GENOMICS_ENGLAND;UNIPROT
TgenePHGDHC0006142Malignant neoplasm of breast1CTD_human
TgenePHGDHC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgenePHGDHC0007621Neoplastic Cell Transformation1CTD_human
TgenePHGDHC0023903Liver neoplasms1CTD_human
TgenePHGDHC0025202melanoma1CTD_human
TgenePHGDHC0033578Prostatic Neoplasms1CTD_human
TgenePHGDHC0265218Neu-Laxova syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgenePHGDHC0345904Malignant neoplasm of liver1CTD_human
TgenePHGDHC0376358Malignant neoplasm of prostate1CTD_human
TgenePHGDHC05801903-Phosphoglycerate dehydrogenase deficiency1ORPHANET
TgenePHGDHC0678222Breast Carcinoma1CTD_human
TgenePHGDHC1257931Mammary Neoplasms, Human1CTD_human
TgenePHGDHC1458155Mammary Neoplasms1CTD_human
TgenePHGDHC4704874Mammary Carcinoma, Human1CTD_human