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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTLL3-TGFB1 (FusionGDB2 ID:94503)

Fusion Gene Summary for TTLL3-TGFB1

check button Fusion gene summary
Fusion gene informationFusion gene name: TTLL3-TGFB1
Fusion gene ID: 94503
HgeneTgene
Gene symbol

TTLL3

TGFB1

Gene ID

26140

7040

Gene nametubulin tyrosine ligase like 3transforming growth factor beta 1
SynonymsHOTTLCED|DPD1|IBDIMDE|LAP|TGF-beta1|TGFB|TGFbeta
Cytomap

3p25.3

19q13.2

Type of geneprotein-codingprotein-coding
Descriptiontubulin monoglycylase TTLL3tubulin tyrosine ligase-like family, member 3tubulin--tyrosine ligase-like protein 3transforming growth factor beta-1 proproteinTGF-beta-1latency-associated peptideprepro-transforming growth factor beta-1transforming growth factor beta1
Modification date2020031320200329
UniProtAcc.

TIAF1

Ensembl transtripts involved in fusion geneENST00000426895, ENST00000547186, 
ENST00000397241, ENST00000427853, 
ENST00000383827, ENST00000455274, 
ENST00000430793, ENST00000466245, 
ENST00000221930, 
Fusion gene scores* DoF score5 X 5 X 3=758 X 6 X 7=336
# samples 58
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTLL3 [Title/Abstract] AND TGFB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTTLL3(9859443)-TGFB1(41854360), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTTLL3

GO:0018094

protein polyglycylation

19524510

TgeneTGFB1

GO:0001837

epithelial to mesenchymal transition

25893292|29529050

TgeneTGFB1

GO:0001933

negative regulation of protein phosphorylation

8053900

TgeneTGFB1

GO:0001934

positive regulation of protein phosphorylation

18625725

TgeneTGFB1

GO:0002062

chondrocyte differentiation

15040835

TgeneTGFB1

GO:0002244

hematopoietic progenitor cell differentiation

15451575

TgeneTGFB1

GO:0006611

protein export from nucleus

9770491|17438144|18588859

TgeneTGFB1

GO:0006754

ATP biosynthetic process

10513816

TgeneTGFB1

GO:0006796

phosphate-containing compound metabolic process

10513816

TgeneTGFB1

GO:0006954

inflammatory response

21147091

TgeneTGFB1

GO:0007050

cell cycle arrest

14555988

TgeneTGFB1

GO:0007093

mitotic cell cycle checkpoint

15334054

TgeneTGFB1

GO:0007173

epidermal growth factor receptor signaling pathway

18625725

TgeneTGFB1

GO:0007179

transforming growth factor beta receptor signaling pathway

9389648|11157754

TgeneTGFB1

GO:0007182

common-partner SMAD protein phosphorylation

20573232

TgeneTGFB1

GO:0007183

SMAD protein complex assembly

17438144

TgeneTGFB1

GO:0008284

positive regulation of cell proliferation

10513816|14633705

TgeneTGFB1

GO:0008285

negative regulation of cell proliferation

15334054

TgeneTGFB1

GO:0010628

positive regulation of gene expression

18625725|18832382|18941241|19913496|25322725|26634652|26687115|27162619|29167509

TgeneTGFB1

GO:0010629

negative regulation of gene expression

19913496|20067797|22269326|25163461|26634652|29167509|29529050

TgeneTGFB1

GO:0010718

positive regulation of epithelial to mesenchymal transition

17999987|18505915

TgeneTGFB1

GO:0010763

positive regulation of fibroblast migration

18555217

TgeneTGFB1

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

18625725|19736306

TgeneTGFB1

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

9389648|19736306|26634652

TgeneTGFB1

GO:0010936

negative regulation of macrophage cytokine production

20875417

TgeneTGFB1

GO:0016477

cell migration

25893292

TgeneTGFB1

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

15334054

TgeneTGFB1

GO:0022408

negative regulation of cell-cell adhesion

18593713

TgeneTGFB1

GO:0030214

hyaluronan catabolic process

17324121

TgeneTGFB1

GO:0030308

negative regulation of cell growth

15334054

TgeneTGFB1

GO:0030335

positive regulation of cell migration

19736306

TgeneTGFB1

GO:0031293

membrane protein intracellular domain proteolysis

25310401

TgeneTGFB1

GO:0031334

positive regulation of protein complex assembly

19366691

TgeneTGFB1

GO:0031663

lipopolysaccharide-mediated signaling pathway

21147091

TgeneTGFB1

GO:0032270

positive regulation of cellular protein metabolic process

15219857

TgeneTGFB1

GO:0032355

response to estradiol

18039789

TgeneTGFB1

GO:0032570

response to progesterone

18039789

TgeneTGFB1

GO:0032740

positive regulation of interleukin-17 production

18453574

TgeneTGFB1

GO:0032801

receptor catabolic process

17878231

TgeneTGFB1

GO:0032930

positive regulation of superoxide anion generation

22073128

TgeneTGFB1

GO:0032967

positive regulation of collagen biosynthetic process

19734317|22269326|25310401

TgeneTGFB1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

18625725|19736306

TgeneTGFB1

GO:0035307

positive regulation of protein dephosphorylation

14555988

TgeneTGFB1

GO:0042307

positive regulation of protein import into nucleus

19366691

TgeneTGFB1

GO:0043117

positive regulation of vascular permeability

21168935

TgeneTGFB1

GO:0043406

positive regulation of MAP kinase activity

18625725

TgeneTGFB1

GO:0043536

positive regulation of blood vessel endothelial cell migration

18555217

TgeneTGFB1

GO:0043537

negative regulation of blood vessel endothelial cell migration

18555217

TgeneTGFB1

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

18625725

TgeneTGFB1

GO:0045216

cell-cell junction organization

18505915

TgeneTGFB1

GO:0045599

negative regulation of fat cell differentiation

15040835

TgeneTGFB1

GO:0045662

negative regulation of myoblast differentiation

9770491

TgeneTGFB1

GO:0045786

negative regulation of cell cycle

11502704

TgeneTGFB1

GO:0045892

negative regulation of transcription, DNA-templated

15702480|18832382

TgeneTGFB1

GO:0045893

positive regulation of transcription, DNA-templated

9389648|14517293|15334054|16816361

TgeneTGFB1

GO:0045918

negative regulation of cytolysis

24586048

TgeneTGFB1

GO:0045930

negative regulation of mitotic cell cycle

14555988

TgeneTGFB1

GO:0045944

positive regulation of transcription by RNA polymerase II

18832382

TgeneTGFB1

GO:0048298

positive regulation of isotype switching to IgA isotypes

14988498

TgeneTGFB1

GO:0048642

negative regulation of skeletal muscle tissue development

9770491

TgeneTGFB1

GO:0050680

negative regulation of epithelial cell proliferation

9950587

TgeneTGFB1

GO:0050714

positive regulation of protein secretion

18505915

TgeneTGFB1

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

21168935

TgeneTGFB1

GO:0050921

positive regulation of chemotaxis

18555217

TgeneTGFB1

GO:0051897

positive regulation of protein kinase B signaling

18625725

TgeneTGFB1

GO:0060389

pathway-restricted SMAD protein phosphorylation

11157754|17999987|18453574|25893292

TgeneTGFB1

GO:0060390

regulation of SMAD protein signal transduction

25893292

TgeneTGFB1

GO:0060391

positive regulation of SMAD protein signal transduction

9389648|19366691|29167509

TgeneTGFB1

GO:0070168

negative regulation of biomineral tissue development

26634652

TgeneTGFB1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

25310401

TgeneTGFB1

GO:0070723

response to cholesterol

17878231

TgeneTGFB1

GO:0071407

cellular response to organic cyclic compound

21147091

TgeneTGFB1

GO:0071560

cellular response to transforming growth factor beta stimulus

19736306|22269326

TgeneTGFB1

GO:0085029

extracellular matrix assembly

19734317

TgeneTGFB1

GO:0090263

positive regulation of canonical Wnt signaling pathway

12893825|15040835

TgeneTGFB1

GO:0097191

extrinsic apoptotic signaling pathway

15334054

TgeneTGFB1

GO:1900126

negative regulation of hyaluronan biosynthetic process

17324121

TgeneTGFB1

GO:1900182

positive regulation of protein localization to nucleus

26634652

TgeneTGFB1

GO:1901666

positive regulation of NAD+ ADP-ribosyltransferase activity

22073128

TgeneTGFB1

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

26311719|26493107

TgeneTGFB1

GO:1903077

negative regulation of protein localization to plasma membrane

21168935|24586048

TgeneTGFB1

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

18548003

TgeneTGFB1

GO:2000679

positive regulation of transcription regulatory region DNA binding

22073128

TgeneTGFB1

GO:2000727

positive regulation of cardiac muscle cell differentiation

25163461


check buttonFusion gene breakpoints across TTLL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TGFB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-A3-3306-01ATTLL3chr3

9859443

+TGFB1chr19

41854360

-


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Fusion Gene ORF analysis for TTLL3-TGFB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000426895ENST00000221930TTLL3chr3

9859443

+TGFB1chr19

41854360

-
In-frameENST00000547186ENST00000221930TTLL3chr3

9859443

+TGFB1chr19

41854360

-
5UTR-3CDSENST00000397241ENST00000221930TTLL3chr3

9859443

+TGFB1chr19

41854360

-
5UTR-3CDSENST00000427853ENST00000221930TTLL3chr3

9859443

+TGFB1chr19

41854360

-
intron-3CDSENST00000383827ENST00000221930TTLL3chr3

9859443

+TGFB1chr19

41854360

-
intron-3CDSENST00000455274ENST00000221930TTLL3chr3

9859443

+TGFB1chr19

41854360

-
intron-3CDSENST00000430793ENST00000221930TTLL3chr3

9859443

+TGFB1chr19

41854360

-
intron-3CDSENST00000466245ENST00000221930TTLL3chr3

9859443

+TGFB1chr19

41854360

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000426895TTLL3chr39859443+ENST00000221930TGFB1chr1941854360-2425878191695558
ENST00000547186TTLL3chr39859443+ENST00000221930TGFB1chr1941854360-2193646841463459

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000426895ENST00000221930TTLL3chr39859443+TGFB1chr1941854360-0.037823890.9621761
ENST00000547186ENST00000221930TTLL3chr39859443+TGFB1chr1941854360-0.0078452590.9921548

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Fusion Genomic Features for TTLL3-TGFB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TTLL3-TGFB1


check button Go to

FGviewer for the breakpoints of chr3:9859443-chr19:41854360

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TGFB1

TIAF1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.115

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTGFB1chr3:9859443chr19:41854360ENST0000022193007244_246118.33333333333333391.0MotifCell attachment site
TgeneTGFB1chr3:9859443chr19:41854360ENST0000022193007226_252118.33333333333333391.0RegionBowtie tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTLL3chr3:9859443chr19:41854360ENST00000383827+15151_5100353.0DomainTTL
HgeneTTLL3chr3:9859443chr19:41854360ENST00000397241+512151_5100714.6666666666666DomainTTL
HgeneTTLL3chr3:9859443chr19:41854360ENST00000427853+39151_5100353.0DomainTTL
HgeneTTLL3chr3:9859443chr19:41854360ENST00000430793+16151_5100435.0DomainTTL
HgeneTTLL3chr3:9859443chr19:41854360ENST00000547186+513151_510143.33333333333334773.0DomainTTL
HgeneTTLL3chr3:9859443chr19:41854360ENST00000383827+15321_3240353.0Nucleotide bindingATP binding
HgeneTTLL3chr3:9859443chr19:41854360ENST00000397241+512321_3240714.6666666666666Nucleotide bindingATP binding
HgeneTTLL3chr3:9859443chr19:41854360ENST00000427853+39321_3240353.0Nucleotide bindingATP binding
HgeneTTLL3chr3:9859443chr19:41854360ENST00000430793+16321_3240435.0Nucleotide bindingATP binding
HgeneTTLL3chr3:9859443chr19:41854360ENST00000547186+513321_324143.33333333333334773.0Nucleotide bindingATP binding
TgeneTGFB1chr3:9859443chr19:41854360ENST000002219300730_74118.33333333333333391.0RegionStraightjacket domain
TgeneTGFB1chr3:9859443chr19:41854360ENST000002219300775_271118.33333333333333391.0RegionArm domain


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Fusion Gene Sequence for TTLL3-TGFB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000426895_ENST00000221930_TCGA-A3-3306-01A_TTLL3_chr3_9859443_+_TGFB1_chr19_41854360_length(transcript)=2425nt_BP=878nt
CGAGCGCGGCGAGGGGCGCATGCAGGGCCCCGACGCGCCACTGCTCCTGAGCGCGAGGGAGCTGGGGCCCGGGCGCCGGGGCTCGGCCTC
CTGGTACCGCCAGGAGGGCGGCGCGGTGTGCAACTGGCTGCGGAAGCCGCAGCCGCTCGAGCCACGCACCAGTTTCCCCTCGGCGCGCCG
CTCCGAGTTCCGTCCACCCAGGAGGCTGCCATGGGCCGGCCCTGCCTCCGCCCAGTCCGAGGAGGGTCACGCAGGCGGCAGATGCCAGGC
GGGCAGCCCCGCCCCTGCGCGCCGCCTCAGCGGCGCCTTCAAGACGCTGGTCCCAGGCACCCACGCCCAGGGCGCCTCGGATACCCACCC
CCTCGGCCCCCCGCACACCCCGGTCCTCGACCCCTCTCCGCAGGATGGTTTCCCGGTCCTCTGGCGAGGATCCTCCAAGGCGTCTCACAT
GAACCGGCTCAGAAACGCCAAAATCTACGTGGAGAGAGCTGTCAAGCAGAAGAAGATCTTTACAATCCAAGGCTGCTACCCGGTGATCCG
GTGTCTCTTGCGCCGGAGGGGCTGGGTGGAGAAGAAGATGGTCCATCGCTCAGGCCCCACCCTGCTGCCACCCCAGAAGGATCTGGATAG
CTCAGCGATGGGTGACAGTGACACCACTGAGGATGAGGATGAAGATGAGGACGAGGAGTTCCAGCCATCACAGCTGTTCGACTTCGATGA
TTTACTGAAATTTGATGACCTAGATGGAACACATGCTCTGATGGTGGGTCTATGTCTCAATCTCCGGAATTTGCCGTGGTTTGATGAGGT
TGATGCCAACTCCTTCTTCCCACGCTGCTACTGCCTGGGGGCTGAGGATGACAAAAAAGCCTTCATAGAAATCTATGACAAGTTCAAGCA
GAGTACACACAGCATATATATGTTCTTCAACACATCAGAGCTCCGAGAAGCGGTACCTGAACCCGTGTTGCTCTCCCGGGCAGAGCTGCG
TCTGCTGAGGCTCAAGTTAAAAGTGGAGCAGCACGTGGAGCTGTACCAGAAATACAGCAACAATTCCTGGCGATACCTCAGCAACCGGCT
GCTGGCACCCAGCGACTCGCCAGAGTGGTTATCTTTTGATGTCACCGGAGTTGTGCGGCAGTGGTTGAGCCGTGGAGGGGAAATTGAGGG
CTTTCGCCTTAGCGCCCACTGCTCCTGTGACAGCAGGGATAACACACTGCAAGTGGACATCAACGGGTTCACTACCGGCCGCCGAGGTGA
CCTGGCCACCATTCATGGCATGAACCGGCCTTTCCTGCTTCTCATGGCCACCCCGCTGGAGAGGGCCCAGCATCTGCAAAGCTCCCGGCA
CCGCCGAGCCCTGGACACCAACTATTGCTTCAGCTCCACGGAGAAGAACTGCTGCGTGCGGCAGCTGTACATTGACTTCCGCAAGGACCT
CGGCTGGAAGTGGATCCACGAGCCCAAGGGCTACCATGCCAACTTCTGCCTCGGGCCCTGCCCCTACATTTGGAGCCTGGACACGCAGTA
CAGCAAGGTCCTGGCCCTGTACAACCAGCATAACCCGGGCGCCTCGGCGGCGCCGTGCTGCGTGCCGCAGGCGCTGGAGCCGCTGCCCAT
CGTGTACTACGTGGGCCGCAAGCCCAAGGTGGAGCAGCTGTCCAACATGATCGTGCGCTCCTGCAAGTGCAGCTGAGGTCCCGCCCCGCC
CCGCCCCGCCCCGGCAGGCCCGGCCCCACCCCGCCCCGCCCCCGCTGCCTTGCCCATGGGGGCTGTATTTAAGGACACCCGTGCCCCAAG
CCCACCTGGGGCCCCATTAAAGATGGAGAGAGGACTGCGGATCTCTGTGTCATTGGGCGCCTGCCTGGGGTCTCCATCCCTGACGTTCCC
CCACTCCCACTCCCTCTCTCTCCCTCTCTGCCTCCTCCTGCCTGTCTGCACTATTCCTTTGCCCGGCATCAAGGCACAGGGGACCAGTGG
GGAACACTACTGTAGTTAGATCTATTTATTGAGCACCTTGGGCACTGTTGAAGTGCCTTACATTAATGAACTCATTCAGTCACCATAGCA
ACACTCTGAGATGCAGGGACTCTGATAACACCCATTTTAAAGGTGAGGAAACAAGCCCAGAGAGGTTAAGGGAGGAGTTCCTGCCCACCA
GGAACCTGCTTTAGTGGGGGATAGTGAAGAAGACAATAAAAGATAGTAGTTCAGGCCAGGCGGGGTGGCTCACGCCTGTAATCCTAGCAC
TTTTGGGAGGCAGAGATGGGAGGATTACTTGAATCCAGGCATTTGAGACCAGCCTGGGTAACATAGTGAGACCCTATCTCTACAAAACAC

>In-frame_ENST00000426895_ENST00000221930_TCGA-A3-3306-01A_TTLL3_chr3_9859443_+_TGFB1_chr19_41854360_length(amino acids)=558AA_start in transcript=19_stop in transcript=1695
MQGPDAPLLLSARELGPGRRGSASWYRQEGGAVCNWLRKPQPLEPRTSFPSARRSEFRPPRRLPWAGPASAQSEEGHAGGRCQAGSPAPA
RRLSGAFKTLVPGTHAQGASDTHPLGPPHTPVLDPSPQDGFPVLWRGSSKASHMNRLRNAKIYVERAVKQKKIFTIQGCYPVIRCLLRRR
GWVEKKMVHRSGPTLLPPQKDLDSSAMGDSDTTEDEDEDEDEEFQPSQLFDFDDLLKFDDLDGTHALMVGLCLNLRNLPWFDEVDANSFF
PRCYCLGAEDDKKAFIEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDS
PEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDT
NYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGR

--------------------------------------------------------------
>In-frame_ENST00000547186_ENST00000221930_TCGA-A3-3306-01A_TTLL3_chr3_9859443_+_TGFB1_chr19_41854360_length(transcript)=2193nt_BP=646nt
CAGTCCGAGGAGGGTCACGCAGGCGGCAGATGCCAGGCGGGCAGCCCCGCCCCTGCGCGCCGCCTCAGCGGCGCCTTCAAGACGCTGGTC
CCAGGCACCCACGCCCAGGGCGCCTCGGATACCCACCCCCTCGGCCCCCCGCACACCCCGGTCCTCGACCCCTCTCCGCAGGATGGTTTC
CCGGTCCTCTGGCGAGGATCCTCCAAGGCGTCTCACATGAACCGGCTCAGAAACGCCAAAATCTACGTGGAGAGAGCTGTCAAGCAGAAG
AAGATCTTTACAATCCAAGGCTGCTACCCGGTGATCCGGTGTCTCTTGCGCCGGAGGGGCTGGGTGGAGAAGAAGATGGTCCATCGCTCA
GGCCCCACCCTGCTGCCACCCCAGAAGGATCTGGATAGCTCAGCGATGGGTGACAGTGACACCACTGAGGATGAGGATGAAGATGAGGAC
GAGGAGTTCCAGCCATCACAGCTGTTCGACTTCGATGATTTACTGAAATTTGATGACCTAGATGGAACACATGCTCTGATGGTGGGTCTA
TGTCTCAATCTCCGGAATTTGCCGTGGTTTGATGAGGTTGATGCCAACTCCTTCTTCCCACGCTGCTACTGCCTGGGGGCTGAGGATGAC
AAAAAAGCCTTCATAGAAATCTATGACAAGTTCAAGCAGAGTACACACAGCATATATATGTTCTTCAACACATCAGAGCTCCGAGAAGCG
GTACCTGAACCCGTGTTGCTCTCCCGGGCAGAGCTGCGTCTGCTGAGGCTCAAGTTAAAAGTGGAGCAGCACGTGGAGCTGTACCAGAAA
TACAGCAACAATTCCTGGCGATACCTCAGCAACCGGCTGCTGGCACCCAGCGACTCGCCAGAGTGGTTATCTTTTGATGTCACCGGAGTT
GTGCGGCAGTGGTTGAGCCGTGGAGGGGAAATTGAGGGCTTTCGCCTTAGCGCCCACTGCTCCTGTGACAGCAGGGATAACACACTGCAA
GTGGACATCAACGGGTTCACTACCGGCCGCCGAGGTGACCTGGCCACCATTCATGGCATGAACCGGCCTTTCCTGCTTCTCATGGCCACC
CCGCTGGAGAGGGCCCAGCATCTGCAAAGCTCCCGGCACCGCCGAGCCCTGGACACCAACTATTGCTTCAGCTCCACGGAGAAGAACTGC
TGCGTGCGGCAGCTGTACATTGACTTCCGCAAGGACCTCGGCTGGAAGTGGATCCACGAGCCCAAGGGCTACCATGCCAACTTCTGCCTC
GGGCCCTGCCCCTACATTTGGAGCCTGGACACGCAGTACAGCAAGGTCCTGGCCCTGTACAACCAGCATAACCCGGGCGCCTCGGCGGCG
CCGTGCTGCGTGCCGCAGGCGCTGGAGCCGCTGCCCATCGTGTACTACGTGGGCCGCAAGCCCAAGGTGGAGCAGCTGTCCAACATGATC
GTGCGCTCCTGCAAGTGCAGCTGAGGTCCCGCCCCGCCCCGCCCCGCCCCGGCAGGCCCGGCCCCACCCCGCCCCGCCCCCGCTGCCTTG
CCCATGGGGGCTGTATTTAAGGACACCCGTGCCCCAAGCCCACCTGGGGCCCCATTAAAGATGGAGAGAGGACTGCGGATCTCTGTGTCA
TTGGGCGCCTGCCTGGGGTCTCCATCCCTGACGTTCCCCCACTCCCACTCCCTCTCTCTCCCTCTCTGCCTCCTCCTGCCTGTCTGCACT
ATTCCTTTGCCCGGCATCAAGGCACAGGGGACCAGTGGGGAACACTACTGTAGTTAGATCTATTTATTGAGCACCTTGGGCACTGTTGAA
GTGCCTTACATTAATGAACTCATTCAGTCACCATAGCAACACTCTGAGATGCAGGGACTCTGATAACACCCATTTTAAAGGTGAGGAAAC
AAGCCCAGAGAGGTTAAGGGAGGAGTTCCTGCCCACCAGGAACCTGCTTTAGTGGGGGATAGTGAAGAAGACAATAAAAGATAGTAGTTC
AGGCCAGGCGGGGTGGCTCACGCCTGTAATCCTAGCACTTTTGGGAGGCAGAGATGGGAGGATTACTTGAATCCAGGCATTTGAGACCAG
CCTGGGTAACATAGTGAGACCCTATCTCTACAAAACACTTTTAAAAAATGTACACCTGTGGTCCCAGCTACTCTGGAGGCTAAGGTGGGA

>In-frame_ENST00000547186_ENST00000221930_TCGA-A3-3306-01A_TTLL3_chr3_9859443_+_TGFB1_chr19_41854360_length(amino acids)=459AA_start in transcript=84_stop in transcript=1463
MVPGTHAQGASDTHPLGPPHTPVLDPSPQDGFPVLWRGSSKASHMNRLRNAKIYVERAVKQKKIFTIQGCYPVIRCLLRRRGWVEKKMVH
RSGPTLLPPQKDLDSSAMGDSDTTEDEDEDEDEEFQPSQLFDFDDLLKFDDLDGTHALMVGLCLNLRNLPWFDEVDANSFFPRCYCLGAE
DDKKAFIEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVT
GVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEK
NCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TTLL3-TGFB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTLL3-TGFB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTLL3-TGFB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTGFB1C0016059Fibrosis8CTD_human
TgeneTGFB1C1623038Cirrhosis8CTD_human
TgeneTGFB1C0034069Pulmonary Fibrosis7CTD_human
TgeneTGFB1C4721507Alveolitis, Fibrosing7CTD_human
TgeneTGFB1C0011989Camurati-Engelmann Syndrome5CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTGFB1C0023893Liver Cirrhosis, Experimental5CTD_human
TgeneTGFB1C0027626Neoplasm Invasiveness5CTD_human
TgeneTGFB1C0027627Neoplasm Metastasis4CTD_human
TgeneTGFB1C0017668Focal glomerulosclerosis3CTD_human
TgeneTGFB1C0022658Kidney Diseases3CTD_human
TgeneTGFB1C0024121Lung Neoplasms3CTD_human
TgeneTGFB1C0027726Nephrotic Syndrome3CTD_human
TgeneTGFB1C0086432Hyalinosis, Segmental Glomerular3CTD_human
TgeneTGFB1C0242379Malignant neoplasm of lung3CTD_human
TgeneTGFB1C0002152Alloxan Diabetes2CTD_human
TgeneTGFB1C0004096Asthma2CTD_human
TgeneTGFB1C0005138Berylliosis2CTD_human
TgeneTGFB1C0005398Cholestasis, Extrahepatic2CTD_human
TgeneTGFB1C0011853Diabetes Mellitus, Experimental2CTD_human
TgeneTGFB1C0011881Diabetic Nephropathy2CTD_human
TgeneTGFB1C0017667Nodular glomerulosclerosis2CTD_human
TgeneTGFB1C0020517Hypersensitivity2CTD_human
TgeneTGFB1C0020538Hypertensive disease2CTD_human
TgeneTGFB1C0021368Inflammation2CTD_human
TgeneTGFB1C0033578Prostatic Neoplasms2CTD_human
TgeneTGFB1C0038433Streptozotocin Diabetes2CTD_human
TgeneTGFB1C0376358Malignant neoplasm of prostate2CTD_human
TgeneTGFB1C1527304Allergic Reaction2CTD_human
TgeneTGFB1C2350873Beryllium Disease2CTD_human
TgeneTGFB1C0000786Spontaneous abortion1CTD_human
TgeneTGFB1C0000822Abortion, Tubal1CTD_human
TgeneTGFB1C0001418Adenocarcinoma1CTD_human
TgeneTGFB1C0001787Osteoporosis, Age-Related1CTD_human
TgeneTGFB1C0003504Aortic Valve Insufficiency1CTD_human
TgeneTGFB1C0005586Bipolar Disorder1PSYGENET
TgeneTGFB1C0006111Brain Diseases1CTD_human
TgeneTGFB1C0006663Calcinosis1CTD_human
TgeneTGFB1C0007097Carcinoma1CTD_human
TgeneTGFB1C0007114Malignant neoplasm of skin1CTD_human
TgeneTGFB1C0007137Squamous cell carcinoma1CTD_human
TgeneTGFB1C0007140Carcinosarcoma1CTD_human
TgeneTGFB1C0007621Neoplastic Cell Transformation1CTD_human
TgeneTGFB1C0008312Primary biliary cirrhosis1CTD_human
TgeneTGFB1C0008925Cleft Palate1CTD_human
TgeneTGFB1C0009402Colorectal Carcinoma1CTD_human
TgeneTGFB1C0009404Colorectal Neoplasms1CTD_human
TgeneTGFB1C0010474Curling Ulcer1CTD_human
TgeneTGFB1C0010674Cystic Fibrosis1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneTGFB1C0011581Depressive disorder1PSYGENET
TgeneTGFB1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneTGFB1C0011882Diabetic Neuropathies1CTD_human
TgeneTGFB1C0013238Dry Eye Syndromes1CTD_human
TgeneTGFB1C0013264Muscular Dystrophy, Duchenne1CTD_human
TgeneTGFB1C0013295Duodenal Ulcer1CTD_human
TgeneTGFB1C0014544Epilepsy1CTD_human
TgeneTGFB1C0017661IGA Glomerulonephritis1CTD_human
TgeneTGFB1C0019189Hepatitis, Chronic1CTD_human
TgeneTGFB1C0019207Hepatoma, Morris1CTD_human
TgeneTGFB1C0019208Hepatoma, Novikoff1CTD_human
TgeneTGFB1C0019209Hepatomegaly1CTD_human
TgeneTGFB1C0019284Diaphragmatic Hernia1CTD_human
TgeneTGFB1C0020507Hyperplasia1CTD_human
TgeneTGFB1C0021290Neonatal disorder1CTD_human
TgeneTGFB1C0021390Inflammatory Bowel Diseases1CTD_human
TgeneTGFB1C0022660Kidney Failure, Acute1CTD_human
TgeneTGFB1C0022661Kidney Failure, Chronic1CTD_human
TgeneTGFB1C0023890Liver Cirrhosis1CTD_human
TgeneTGFB1C0023891Liver Cirrhosis, Alcoholic1CTD_human
TgeneTGFB1C0023892Biliary cirrhosis1CTD_human
TgeneTGFB1C0023904Liver Neoplasms, Experimental1CTD_human
TgeneTGFB1C0024115Lung diseases1CTD_human
TgeneTGFB1C0024117Chronic Obstructive Airway Disease1CTD_human
TgeneTGFB1C0026848Myopathy1CTD_human
TgeneTGFB1C0027051Myocardial Infarction1CTD_human
TgeneTGFB1C0027719Nephrosclerosis1CTD_human
TgeneTGFB1C0028797Occupational Diseases1CTD_human
TgeneTGFB1C0029172Oral Submucous Fibrosis1CTD_human
TgeneTGFB1C0029408Degenerative polyarthritis1CTD_human
TgeneTGFB1C0029456Osteoporosis1CTD_human
TgeneTGFB1C0029458Osteoporosis, Postmenopausal1CTD_human
TgeneTGFB1C0029459Osteoporosis, Senile1CTD_human
TgeneTGFB1C0030297Pancreatic Neoplasm1CTD_human
TgeneTGFB1C0030354Papilloma1CTD_human
TgeneTGFB1C0030848Peyronie Disease1CTD_human
TgeneTGFB1C0032226Pleural Diseases1CTD_human
TgeneTGFB1C0032285Pneumonia1CTD_human
TgeneTGFB1C0032300Lobar Pneumonia1CTD_human
TgeneTGFB1C0033687Proteinuria1CTD_human
TgeneTGFB1C0033975Psychotic Disorders1PSYGENET
TgeneTGFB1C0034067Pulmonary Emphysema1CTD_human
TgeneTGFB1C0034189Pyemia1CTD_human
TgeneTGFB1C0036202Sarcoidosis1CTD_human
TgeneTGFB1C0036341Schizophrenia1PSYGENET
TgeneTGFB1C0036690Septicemia1CTD_human
TgeneTGFB1C0037286Skin Neoplasms1CTD_human
TgeneTGFB1C0038454Cerebrovascular accident1CTD_human
TgeneTGFB1C0040028Thrombocythemia, Essential1CTD_human
TgeneTGFB1C0041948Uremia1CTD_human
TgeneTGFB1C0041956Ureteral obstruction1CTD_human
TgeneTGFB1C0042109Urticaria1CTD_human
TgeneTGFB1C0085584Encephalopathies1CTD_human
TgeneTGFB1C0086132Depressive Symptoms1PSYGENET
TgeneTGFB1C0086237Epilepsy, Cryptogenic1CTD_human
TgeneTGFB1C0086404Experimental Hepatoma1CTD_human
TgeneTGFB1C0086743Osteoarthrosis Deformans1CTD_human
TgeneTGFB1C0149519Chronic Persistent Hepatitis1CTD_human
TgeneTGFB1C0158266Intervertebral Disc Degeneration1CTD_human
TgeneTGFB1C0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneTGFB1C0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneTGFB1C0205643Carcinoma, Cribriform1CTD_human
TgeneTGFB1C0205644Carcinoma, Granular Cell1CTD_human
TgeneTGFB1C0205645Adenocarcinoma, Tubular1CTD_human
TgeneTGFB1C0205696Anaplastic carcinoma1CTD_human
TgeneTGFB1C0205697Carcinoma, Spindle-Cell1CTD_human
TgeneTGFB1C0205698Undifferentiated carcinoma1CTD_human
TgeneTGFB1C0205699Carcinomatosis1CTD_human
TgeneTGFB1C0205874Papilloma, Squamous Cell1CTD_human
TgeneTGFB1C0205875Papillomatosis1CTD_human
TgeneTGFB1C0221227Centriacinar Emphysema1CTD_human
TgeneTGFB1C0236018Aura1CTD_human
TgeneTGFB1C0238065Secondary Biliary Cholangitis1CTD_human
TgeneTGFB1C0239946Fibrosis, Liver1CTD_human
TgeneTGFB1C0241910Autoimmune Chronic Hepatitis1CTD_human
TgeneTGFB1C0242488Acute Lung Injury1CTD_human
TgeneTGFB1C0243026Sepsis1CTD_human
TgeneTGFB1C0263628Tumoral calcinosis1CTD_human
TgeneTGFB1C0264393Panacinar Emphysema1CTD_human
TgeneTGFB1C0264423Asthma, Occupational1CTD_human
TgeneTGFB1C0265287Acromicric Dysplasia1CTD_human
TgeneTGFB1C0271673Symmetric Diabetic Proximal Motor Neuropathy1CTD_human
TgeneTGFB1C0271674Asymmetric Diabetic Proximal Motor Neuropathy1CTD_human
TgeneTGFB1C0271678Diabetic Mononeuropathy1CTD_human
TgeneTGFB1C0271680Diabetic Polyneuropathies1CTD_human
TgeneTGFB1C0271685Diabetic Amyotrophy1CTD_human
TgeneTGFB1C0271686Diabetic Autonomic Neuropathy1CTD_human
TgeneTGFB1C0346647Malignant neoplasm of pancreas1CTD_human
TgeneTGFB1C0349204Nonorganic psychosis1PSYGENET
TgeneTGFB1C0393835Diabetic Asymmetric Polyneuropathy1CTD_human
TgeneTGFB1C0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgeneTGFB1C0455503H/O: depression1PSYGENET
TgeneTGFB1C0520463Chronic active hepatitis1CTD_human
TgeneTGFB1C0521174Microcalcification1CTD_human
TgeneTGFB1C0521607Peritoneal Fibrosis1CTD_human
TgeneTGFB1C0524611Cryptogenic Chronic Hepatitis1CTD_human
TgeneTGFB1C0525045Mood Disorders1PSYGENET
TgeneTGFB1C0553980Endomyocardial Fibrosis1CTD_human
TgeneTGFB1C0600519Ventricular Remodeling1CTD_human
TgeneTGFB1C0600520Left Ventricle Remodeling1CTD_human
TgeneTGFB1C0751074Diabetic Neuralgia1CTD_human
TgeneTGFB1C0751111Awakening Epilepsy1CTD_human
TgeneTGFB1C0751406Post-Traumatic Osteoporosis1CTD_human
TgeneTGFB1C0751956Acute Cerebrovascular Accidents1CTD_human
TgeneTGFB1C0878576Posterior Leukoencephalopathy Syndrome1CTD_human
TgeneTGFB1C0887898Experimental Lung Inflammation1CTD_human
TgeneTGFB1C0917713Becker Muscular Dystrophy1CTD_human
TgeneTGFB1C1306571Hepatic Insufficiency1CTD_human
TgeneTGFB1C1527303Chronic Airflow Obstruction1CTD_human
TgeneTGFB1C1565662Acute Kidney Insufficiency1CTD_human
TgeneTGFB1C1719672Severe Sepsis1CTD_human
TgeneTGFB1C1837218Cleft palate, isolated1CTD_human
TgeneTGFB1C1876165Copper-Overload Cirrhosis1CTD_human
TgeneTGFB1C2239176Liver carcinoma1CTD_human
TgeneTGFB1C2350878Focal Emphysema1CTD_human
TgeneTGFB1C2609414Acute kidney injury1CTD_human
TgeneTGFB1C2717759Degenerative Intervertebral Discs1CTD_human
TgeneTGFB1C2717859Peritoneal Sclerosis1CTD_human
TgeneTGFB1C2717860Encapsulating Peritoneal Sclerosis1CTD_human
TgeneTGFB1C3160858Posterior reversible encephalopathy syndrome1CTD_human
TgeneTGFB1C3241937Nonalcoholic Steatohepatitis1CTD_human
TgeneTGFB1C3489628Thrombocytosis, Autosomal Dominant1CTD_human
TgeneTGFB1C3489726Geleophysic dysplasia1CTD_human
TgeneTGFB1C3542021Duchenne and Becker Muscular Dystrophy1CTD_human
TgeneTGFB1C3714636Pneumonitis1CTD_human
TgeneTGFB1C3830362Early Pregnancy Loss1CTD_human
TgeneTGFB1C4551595Biliary Cirrhosis, Primary, 11CTD_human
TgeneTGFB1C4552766Miscarriage1CTD_human
TgeneTGFB1C4748708INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY1UNIPROT