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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TTLL5-TMED10 (FusionGDB2 ID:94531)

Fusion Gene Summary for TTLL5-TMED10

check button Fusion gene summary
Fusion gene informationFusion gene name: TTLL5-TMED10
Fusion gene ID: 94531
HgeneTgene
Gene symbol

TTLL5

TMED10

Gene ID

254173

10972

Gene nametubulin tyrosine ligase like 10transmembrane p24 trafficking protein 10
SynonymsTTLL5P24(DELTA)|S31I125|S31III125|TMP21|Tmp-21-I|p23|p24d1
Cytomap

1p36.33

14q24.3

Type of geneprotein-codingprotein-coding
Descriptioninactive polyglycylase TTLL10tubulin tyrosine ligase-like family, member 10tubulin tyrosine ligase-like family, member 5tubulin--tyrosine ligase-like protein 10transmembrane emp24 domain-containing protein 1021 kDa transmembrane trafficking proteinp24 family protein delta-1p24deltap24delta1testicular tissue protein Li 206transmembrane emp24-like trafficking protein 10transmembrane protein Tmp21
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000557636, ENST00000286650, 
ENST00000298832, ENST00000556893, 
ENST00000554510, ENST00000556977, 
ENST00000555422, 		ENST00000303575, 
ENST00000557670, 
Fusion gene scores* DoF score22 X 22 X 16=77449 X 9 X 4=324
# samples 3111
** MAII scorelog2(31/7744*10)=-4.64273883200036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/324*10)=-1.55849028935997
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTLL5 [Title/Abstract] AND TMED10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMED10(75643058)-TTLL5(76286350), # samples:2
TTLL5(76259443)-TMED10(75618846), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTTLL5

GO:0018094

protein polyglycylation

19524510

TgeneTMED10

GO:0006886

intracellular protein transport

20427317

TgeneTMED10

GO:0035964

COPI-coated vesicle budding

10052452


check buttonFusion gene breakpoints across TTLL5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TMED10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-6961-01ATTLL5chr14

76259443

+TMED10chr14

75618846

-


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Fusion Gene ORF analysis for TTLL5-TMED10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000557636ENST00000303575TTLL5chr14

76259443

+TMED10chr14

75618846

-
5CDS-intronENST00000557636ENST00000557670TTLL5chr14

76259443

+TMED10chr14

75618846

-
intron-3CDSENST00000286650ENST00000303575TTLL5chr14

76259443

+TMED10chr14

75618846

-
intron-intronENST00000286650ENST00000557670TTLL5chr14

76259443

+TMED10chr14

75618846

-
In-frameENST00000298832ENST00000303575TTLL5chr14

76259443

+TMED10chr14

75618846

-
5CDS-intronENST00000298832ENST00000557670TTLL5chr14

76259443

+TMED10chr14

75618846

-
In-frameENST00000556893ENST00000303575TTLL5chr14

76259443

+TMED10chr14

75618846

-
5CDS-intronENST00000556893ENST00000557670TTLL5chr14

76259443

+TMED10chr14

75618846

-
In-frameENST00000554510ENST00000303575TTLL5chr14

76259443

+TMED10chr14

75618846

-
5CDS-intronENST00000554510ENST00000557670TTLL5chr14

76259443

+TMED10chr14

75618846

-
intron-3CDSENST00000556977ENST00000303575TTLL5chr14

76259443

+TMED10chr14

75618846

-
intron-intronENST00000556977ENST00000557670TTLL5chr14

76259443

+TMED10chr14

75618846

-
intron-3CDSENST00000555422ENST00000303575TTLL5chr14

76259443

+TMED10chr14

75618846

-
intron-intronENST00000555422ENST00000557670TTLL5chr14

76259443

+TMED10chr14

75618846

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000557636TTLL5chr1476259443+ENST00000303575TMED10chr1475618846-7281343121538651216
ENST00000298832TTLL5chr1476259443+ENST00000303575TMED10chr1475618846-7226337620538101201
ENST00000556893TTLL5chr1476259443+ENST00000303575TMED10chr1475618846-57441894432328761
ENST00000554510TTLL5chr1476259443+ENST00000303575TMED10chr1475618846-566718171192251710

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000557636ENST00000303575TTLL5chr1476259443+TMED10chr1475618846-0.0001130030.999887
ENST00000298832ENST00000303575TTLL5chr1476259443+TMED10chr1475618846-0.0001528820.99984705
ENST00000556893ENST00000303575TTLL5chr1476259443+TMED10chr1475618846-0.0002921850.99970776
ENST00000554510ENST00000303575TTLL5chr1476259443+TMED10chr1475618846-0.001049930.99895006

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Fusion Genomic Features for TTLL5-TMED10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TTLL5-TMED10


check button Go to

FGviewer for the breakpoints of chr14:76259443-chr14:75618846

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTLL5chr14:76259443chr14:75618846ENST00000298832+2732552_5571057.01282.0Compositional biasNote=Poly-Arg
HgeneTTLL5chr14:76259443chr14:75618846ENST00000298832+2732582_5901057.01282.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75618846ENST00000298832+2732776_7801057.01282.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75618846ENST00000298832+2732827_8301057.01282.0Compositional biasNote=Poly-Asn
HgeneTTLL5chr14:76259443chr14:75618846ENST00000556893+1317552_557608.0818.0Compositional biasNote=Poly-Arg
HgeneTTLL5chr14:76259443chr14:75618846ENST00000556893+1317582_590608.0818.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75618846ENST00000298832+273262_4071057.01282.0DomainTTL
HgeneTTLL5chr14:76259443chr14:75618846ENST00000556893+131762_407608.0818.0DomainTTL
HgeneTTLL5chr14:76259443chr14:75618846ENST00000298832+2732208_2111057.01282.0Nucleotide bindingATP binding
HgeneTTLL5chr14:76259443chr14:75618846ENST00000556893+1317208_211608.0818.0Nucleotide bindingATP binding
HgeneTTLL5chr14:76259443chr14:75618846ENST00000298832+2732378_4881057.01282.0Regionc-MTBD region
HgeneTTLL5chr14:76259443chr14:75618846ENST00000556893+1317378_488608.0818.0Regionc-MTBD region
TgeneTMED10chr14:76259443chr14:75618846ENST0000030357505211_21975.0220.0MotifNote=COPI vesicle coat-binding
TgeneTMED10chr14:76259443chr14:75618846ENST0000030357505147_17875.0220.0RegionNote=Required for TMED10 and TMED2 cis-Golgi network localization
TgeneTMED10chr14:76259443chr14:75618846ENST0000030357505186_20675.0220.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTLL5chr14:76259443chr14:75618846ENST00000286650+110552_5570270.0Compositional biasNote=Poly-Arg
HgeneTTLL5chr14:76259443chr14:75618846ENST00000286650+110582_5900270.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75618846ENST00000286650+110776_7800270.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75618846ENST00000286650+110827_8300270.0Compositional biasNote=Poly-Asn
HgeneTTLL5chr14:76259443chr14:75618846ENST00000556893+1317776_780608.0818.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75618846ENST00000556893+1317827_830608.0818.0Compositional biasNote=Poly-Asn
HgeneTTLL5chr14:76259443chr14:75618846ENST00000286650+11062_4070270.0DomainTTL
HgeneTTLL5chr14:76259443chr14:75618846ENST00000286650+110208_2110270.0Nucleotide bindingATP binding
HgeneTTLL5chr14:76259443chr14:75618846ENST00000286650+110378_4880270.0Regionc-MTBD region
TgeneTMED10chr14:76259443chr14:75618846ENST000003035750541_19375.0220.0DomainGOLD
TgeneTMED10chr14:76259443chr14:75618846ENST000003035750532_18575.0220.0Topological domainLumenal


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Fusion Gene Sequence for TTLL5-TMED10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000557636_ENST00000303575_TCGA-CV-6961-01A_TTLL5_chr14_76259443_+_TMED10_chr14_75618846_length(transcript)=7281nt_BP=3431nt
GTAGTAACCGGGGAAGCAGCCGTCGGCGGCTGCCCTGAGCCTTCCTGGGGAAGGAGGAGGGAGGTAGGCGCAGAGCGCGGTCCACGCCTG
CTCGCCCCGAACCATGGGAAGATGAGACAGGAATCTGTGCCATCCAAATTGCTTGATCCAGTGAATCTGCTAGGAAAGGTCTCTGAGGCC
CCCGTCTGCTGACTGCATGACAAACCCTAAAGGAAATGCCAATCGTGATGGCCCGGGACCTGGAGGAAACAGCATCATCCTCAGAGGATG
AGGAGGTCATAAGTCAAGAGGATCATCCATGCATCATGTGGACTGGAGGCTGCAGGAGAATTCCAGTTTTGGTATTCCATGCCGACGCTA
TTCTTACAAAGGACAACAATATTAGAGTAATTGGAGAACGTTATCATTTGTCTTATAAGATTGTACGAACGGACAGTCGCCTAGTACGCA
GCATTCTGACAGCCCATGGATTTCATGAAGTTCACCCAAGCAGCACTGACTATAACCTAATGTGGACAGGATCCCACCTGAAGCCCTTCT
TACTGCGCACCCTCTCTGAAGCACAAAAAGTTAATCACTTTCCCAGGTCTTATGAACTTACCCGGAAGGACCGACTGTACAAAAACATTA
TTCGAATGCAGCATACACATGGATTCAAGGCTTTTCACATCCTCCCCCAGACCTTCCTCCTGCCAGCTGAGTACGCGGAATTTTGTAATT
CATATTCGAAGGACCGGGGACCTTGGATAGTAAAACCAGTGGCATCTTCAAGGGGGCGGGGCGTCTACCTGATCAACAATCCAAACCAGA
TCTCCCTGGAAGAGAACATTTTGGTCTCCCGTTACATTAACAACCCCCTGCTCATAGATGATTTCAAGTTTGACGTGCGCCTCTATGTGC
TCGTGACTTCCTATGATCCTCTTGTCATCTATCTCTATGAAGAAGGATTGGCTAGGTTTGCAACTGTGCGATATGATCAAGGAGCCAAGA
ACATTCGGAACCAGTTCATGCATCTGACAAACTACAGTGTCAACAAGAAAAGTGGAGATTACGTCAGTTGTGACGATCCAGAAGTGGAGG
ATTATGGAAACAAATGGAGCATGAGTGCTATGCTTAGGTACCTGAAACAAGAAGGCAGAGATACAACCGCATTGATGGCCCATGTAGAAG
ACCTGATCATTAAGACTATAATCTCTGCTGAACTAGCTATTGCTACTGCCTGTAAAACCTTTGTTCCTCATCGCAGCAGTTGTTTTGAAC
TCTATGGCTTTGACGTGCTCATAGATTCTACTCTGAAGCCATGGTTGTTGGAAGTGAATCTCTCTCCTTCTTTGGCCTGTGATGCGCCTC
TGGACCTAAAGATTAAAGCCAGTATGATTTCAGATATGTTCACTGTTGTAGGATTTGTGTGCCAAGATCCTGCCCAGCGGGCATCAACTC
GGCCAATTTATCCCACCTTTGAGTCTTCCAGGCGAAACCCTTTCCAGAAACCTCAGCGTCCAGTATCTGCACAGTTTCAGTCGTCAAAGG
CCAAGCAGCGTTGCCGTCCACTCTCTGCCAGTGATGCGGAAATGAAAAACCTCGTGGGCTCAGCCCGGGAGAAAGGGCCAGGGAAGTTGG
GTGGTTCTGTGCTTGGTCTGTCAATGGAGGAGATCAAAGTTTTACGAAGGGTGAAGGAGGAGAATGATCGGCGAGGTGGATTTATTCGCA
TATTTCCTACATCTGAGACATGGGAAATATATGGGTCCTACCTCGAGCATAAGACCTCAATGAACTATATGCTGGCAACACGCCTCTTCC
AGGACAGAATGACTGCTGATGGAGCGCCAGAATTGAAGATAGAGAGTCTGAATTCAAAGGCCAAGCTGCATGCTGCACTTTACGAGAGGA
AGCTCCTGTCTCTGGAGGTGCGAAAACGTAGACGACGGAGTAGCAGATTGAGGGCAATGAGGCCAAAATACCCAGTGATTACCCAACCAG
CTGAAATGAATGTTAAAACTGAGACAGAGAGTGAAGAGGAGGAAGAAGTCGCATTAGATAATGAAGATGAAGAACAGGAGGCTTCCCAGG
AGGAGTCTGCAGGATTTCTTAGAGAAAATCAAGCCAAATATACACCCTCATTGACAGCTTTGGTAGAAAATACACCCAAAGAAAATTCCA
TGAAAGTTCGTGAATGGAATAATAAAGGTGGACACTGCTGCAAACTTGAGACTCAGGAGCTAGAGCCTAAATTTAACCTGATGCAGATTC
TTCAAGATAATGGCAATCTTAGCAAAATGCAGGCCCGAATAGCATTCTCTGCCTATCTCCAGCATGTTCAAATTCGCCTGATGAAAGACA
GTGGCGGTCAGACGTTCAGTGCCAGTTGGGCTGCCAAAGAGGATGAACAGATGGAGCTGGTTGTTCGTTTCCTCAAGCGAGCATCAAATA
ACCTCCAGCATTCACTGAGGATGGTATTACCCAGTCGACGATTGGCACTTCTGGAACGCAGAAGAATCCTGGCCCACCAGCTGGGTGACT
TTATCATTGTATACAACAAGGAAACAGAACAAATGGCTGAAAAGAAATCAAAGAAGAAAGTTGAGGAAGAAGAGGAAGATGGGGTGAATA
TGGAAAACTTTCAGGAGTTCATCAGACAAGCAAGTGAGGCTGAACTGGAGGAGGTGTTGACTTTTTATACCCAAAAGAACAAGTCTGCTA
GTGTCTTCCTGGGGACTCACTCTAAAATTTCTAAGAACAACAACAATTATTCTGATAGTGGGGCAAAAGGTGATCACCCTGAGACTATAA
TGGAAGAAGTGAAAATAAAGCCACCTAAACAGCAACAGACGACAGAAATTCATTCTGATAAATTATCTCGATTTACCACTTCAGCAGAAA
AAGAGGCAAAATTAGTTTATAGCAATTCCTCCTCTGGTCCTACTGCTACTCTGCAGAAAATTCCCAACACCCATTTGTCATCTGTTACAA
CCTCTGACCTCTCTCCAGGGCCTTGCCACCATTCTTCTTTATCTCAAATTCCTTCAGCTATCCCCAGCATGCCTCACCAGCCAACAATTT
TACTGAACACAGTCTCTGCCAGTGCTTCTCCCTGCCTACATCCCGGGGCACAGAACATCCCAAGCCCTACTGGCCTGCCACGCTGTCGAT
CAGGAAGTCACACCATTGGTCCCTTTTCTTCCTTCCAAAGTGCTGCACACATCTATAGCCAGAAACTGTCTCGTCCCTCTTCAGCAAAGG
CAGCAGGATCGTGCTATCTAAACAAGCATCATTCAGGAATAGCCAAAACACAAAAAGAGGGAGAAGATGCTTCTTTATATAGCAAACGGT
ACAACCAAAGTATGGTTACAGCTGAACTTCAGCGGCTAGCTGAGAAGCAGGCAGCGAGACAGTATTCTCCATCCAGCCACATCAACCTCC
TCACCCAACAGATCACAGATTCTGCTGGCCATATTCTCTACTCCAAAGAGGATGCAACCAAGGGGAAATTTGCCTTTACCACTGAAGATT
ATGACATGTTTGAAGTGTGTTTTGAGAGCAAGGGAACAGGGCGGATACCTGACCAACTCGTGATCCTAGACATGAAGCATGGAGTGGAGG
CGAAAAATTACGAAGAGATTGCAAAAGTTGAGAAGCTCAAACCATTAGAGGTAGAGCTGCGACGCCTAGAAGACCTTTCAGAATCTATTG
TTAATGATTTTGCCTACATGAAGAAGAGAGAAGAGGAGATGCGTGATACCAACGAGTCAACAAACACTCGGGTCCTATACTTCAGCATCT
TTTCAATGTTCTGTCTCATTGGACTAGCTACCTGGCAGGTCTTCTACCTGCGACGCTTCTTCAAGGCCAAGAAATTGATTGAGTAATGAA
TGAGGCATATTCTCCTCCCACCTTGTACCTCAGCCAGCAGAACATCGCTGGGACGTGCCTGGCCTAAGGCATCCTACCAACAGCACCATC
AAGGCACGTTGGAGCTTTCTTGCCAGAACTGATCTCTTTTGGTGTGGGAGGACATGGGGTACCACCTACACCCAACAAGTCAATGAGGGA
CTTCTTTTTAATTTGGTAGGATTTTGACTGGTTTTGCAACAATAGGTCTATTATTAGAGTCACCTATGACAAAAAATAGGGGTTACCTAG
ATAATGCCAAAGTCAGCATTTGTCCTGGGTTCCCTTGTGTGATCTGTTTGGACTATGTTTTCTTTTCTTCTCCCACTTGCTCAGCAGCTT
GGGCTTCCATTCTAGTTCTTTTACCAAGATTTTTGTGTGACCATGTTGACTTCATTTGGATTGCCCTCTTTCAATTTCCTTGTGAAAACA
CCCTTAACTTTCTCTTTACCCTTAGCTGAAATGTTTACATAGCTTCTGGTGATATCTTTTCATGATTTTATATCTCTTAAAATGGTGATG
GATGTGACACCTCATAAAAGTGAGCTTTGAACTGTAGATAACTCTTAAAGAAAATGTCATTTTAGACAATTAAAATATTTGTGCTCAACT
GCTTGAACTTTTTTCGTGTATGTGTATTTAATTCTATGCAATATTATCACATGTGTAGATTCATGTGACCACCATCACAAGAGACAGAAC
AGTTCTGTCACATGGATCCCTTGCACTGCCCTTTTACAGCCGCAGCCACATCCCTTTCTTATACCCTCACCCCAACCTGTGGCTACCACT
GTTCTGTCCTCCATCTCTGTAATTTTGTCATTTCAAGAATGTTGTATGAATGGAATCATACAGAATGTAATCTTACGAGGCTGATCTTTT
TTCATTCAGCATAATTCCCTTGAAATCCATCCAAGTTGTTGCATGTATGAATAGTTTCTTCCTTTTTTTCTTTTAAAAATGTTTTATATA
TTTAGGGGGTATAAGTACAGATTTCTTACATGCATATATTGCATCGTGGTGAAGTGGGGGCAGTTCCTTTTGATTGCTGAGTAGTATTCC
ATGGTATGGATGTACCACAGTTTGCTTAACCATTCACCCACTAAAGGACATAAGAGTTGTTTTCAGTTTTTTGCCCTAATAAAGCTGCTG
TGAACATTCATGTACAGGTTTTTATGTGAACATACATTTTCATTTTCTGGGATAAATGCTCAAAAGGGCAACTGTTGGGTTGTATGGTAA
ACACATATATTTTTGTAAGAAACTACCCTACTCTTTTTCCAGAGTGGCTCTACTTTTTACATACAGCCACTCATACAATTCAGACAGCAA
TGTATGATTGATCCAGTTTCTTCACATCCTCACCAGCATTTGGTATTACTACTATTTTTTATCTTAACCATTCACATAGATGTGTGTAAT
GATACCACATGTGGTTTTAATTTGCATTTCCAATGGCTAATGATGTTGAGTATCTTTTTGTGTGCTAATTTGCCATCTATGTATCCTCTT
CGGTGAAATGTCTTCATGTCTTTTGTCTATTTTCTATTTAGGTCATTTGTTCTTTTTACTATTGAGTTTTGAGAGGTTTTTTATATATCC
TAGATAAAATTCCTCTGTTAGATATGTGGTTGCTTGAATTTTTAACATAACTTCTACCAAGGAAAAATAAGTAAAATTTCCAACCCTTGC
ATGGCCAGTCACTTACTTAATTCCTGTCCTTCAGTGTTCCATCTAGAGAATTAAGAGATATGATGTATAAAATAGACATCGAGGGCCATT
AAGAGAGTAAATACTTAAAAATACATGTTATGAAAGCAAAGCCAATAATCACTGTAGGAGTATGAGTTGCCTAAGGGCCAAAACTAATGT
AAATAAGAGAAAGTGTGGATATAAATGACCATTGTTTATAAACAGTTATGAAAAATGCTGTGACTTGAAATCTTTCCCACATCTCCCAAG
AAAGTAGGTAGGAGTTTATCCTTTCCGTAATCTCTTTTTAACCCTGCTGACTATTACAGGGCTTGTTTAATCACAGTGGCAAGAATTACA
TGTATCTTACAGTAAAGAAACAGAATACTGGAATCGTTAGAGAACCCTGATGTGTTGACCTGGATAAAGTACAAAGGTGGAAGAGGGAAT
GAGTTATGCTGTTAAAATCTCAGGCTATTCTGTTAATGTTCCTGCTACTATGAACCCAAACTTTTTTTTTCCCCCTTTTGACTCCTTGTG
TCTTCCTCTCCTGTGGCATAAAAGTAGTTCTGTCGTTAACTTGTACAACATTGCCATCTGCTGTTGAGAATTGGTAGGTACTGCTTCTGA
GAACCTGGCTGCAGATCCTTAGCATAGGCAGCAAATGTTGAGAAAGTCTATCTGTAGTATTACATATACTAAGTTACAGAGGATGCATCC
AAGTAGAGAAAATAATATGTGGGTTAAGATACATCCTTAAACTTTTTTTTTTTTGGGGGGGGGGGGACGGAGTCTTGCTGCAACGCCCAG
GCTGGAGTGCAATGGCACTATCTCAGCTCGCTGCAACCTTCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGG
GAATATAGGTGCACACCACCATGCCTGGCTAATTTTTGTATTTTCAGTAGAAGCAGAGTTTCACCATATTGGCCAGGTTGGTCTCGAACT
CCTGACCTCAAGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGCGTGAGCCACCACACCCAGCCTCCATCTTTAAACTT
TTAAATGTGAAATTTCTATCATGTACCGTTAGCCTAACAAGATTTTCTTTCCTATTTCTGACTGGTGCCTTTCCCCTTTTTAGGAGCAAC
GAAAGCTACTCTCTTAGTTATGTTCTTGTGATGTGACAAAATGTCAAGAAGATAGGAGAAGAGAATATTTTATTTCGTTGATGCTTTTGT
TCCCAAGTGTGACCCTAAACTTAAGCTTTGTAGGAGTTGACATTCTTTCATGTCCCTTCCCTTTACTCATGCCGAAACTATCAACTGGGA
CATTTTGTGCTTTTGGTTTAAAAGTTAATTGATATTATACTTTGGTTTTATCTAAAAAGTAAATGTATTTGCCTTTGACAAAAGACTGAC
ACAAGAGCAAATAAGCTTTAAAATCGGGTGTTATGTGCTTTCCTCCATTTTTGAGCATATTATCCAAAATGGTCTGTATAATATAAATGA
GAATGATGCAGTTTAAGTAAGCCTTGTTATACCATTGTCATGGACCCCTGTCATAAAGCCATTTCTTGGTTTGTTTGGGAAAGAGGCATA

>In-frame_ENST00000557636_ENST00000303575_TCGA-CV-6961-01A_TTLL5_chr14_76259443_+_TMED10_chr14_75618846_length(amino acids)=1216AA_start in transcript=215_stop in transcript=3865
MPIVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVFHADAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVH
PSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVK
PVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNY
SVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDSTL
KPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRPVSAQFQSSKAKQRCRPLSASD
AEMKNLVGSAREKGPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRMTADGAPEL
KIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQA
KYTPSLTALVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAA
KEDEQMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQAS
EAELEEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSS
GPTATLQKIPNTHLSSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSF
QSAAHIYSQKLSRPSSAKAAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQITDSAGHI
LYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREE

--------------------------------------------------------------
>In-frame_ENST00000298832_ENST00000303575_TCGA-CV-6961-01A_TTLL5_chr14_76259443_+_TMED10_chr14_75618846_length(transcript)=7226nt_BP=3376nt
GGGAAGCAGCCGTCGGCGGCTGCCCTGAGCCTTCCTGGGGAAGGAGGAGGGAGGTAGGCGCAGAGCGCGGTCCACGCCTGCTCGCCCCGA
ACCATGGGAAGATGAGACAGGAATCTGTGCCATCCAAATTGCTTGATCCAGTGAATCTGCTAGGAAAGGTCTCTGAGGCCCCCGTCTGCT
GACTGCATGACAAACCCTAAAGGAAATGCCAATCGTGATGGCCCGGGACCTGGAGGAAACAGCATCATCCTCAGAGGATGAGGAGGTCAT
AAGTCAAGAGGATCATCCATGCATCATGTGGACTGGAGGCTGCAGGAGAATTCCAGTTTTGGTATTCCATGCCGACGCTATTCTTACAAA
GGACAACAATATTAGAGTAATTGGAGAACGTTATCATTTGTCTTATAAGATTGTACGAACGGACAGTCGCCTAGTACGCAGCATTCTGAC
AGCCCATGGATTTCATGAAGTTCACCCAAGCAGCACTGACTATAACCTAATGTGGACAGGATCCCACCTGAAGCCCTTCTTACTGCGCAC
CCTCTCTGAAGCACAAAAAGTTAATCACTTTCCCAGGTCTTATGAACTTACCCGGAAGGACCGACTGTACAAAAACATTATTCGAATGCA
GCATACACATGGATTCAAGGCTTTTCACATCCTCCCCCAGACCTTCCTCCTGCCAGCTGAGTACGCGGAATTTTGTAATTCATATTCGAA
GGACCGGGGACCTTGGATAGTAAAACCAGTGGCATCTTCAAGGGGGCGGGGCGTCTACCTGATCAACAATCCAAACCAGATCTCCCTGGA
AGAGAACATTTTGGTCTCCCGTTACATTAACAACCCCCTGCTCATAGATGATTTCAAGTTTGACGTGCGCCTCTATGTGCTCGTGACTTC
CTATGATCCTCTTGTCATCTATCTCTATGAAGAAGGATTGGCTAGGTTTGCAACTGTGCGATATGATCAAGGAGCCAAGAACATTCGGAA
CCAGTTCATGCATCTGACAAACTACAGTGTCAACAAGAAAAGTGGAGATTACGTCAGTTGTGACGATCCAGAAGTGGAGGATTATGGAAA
CAAATGGAGCATGAGTGCTATGCTTAGGTACCTGAAACAAGAAGGCAGAGATACAACCGCATTGATGGCCCATGTAGAAGACCTGATCAT
TAAGACTATAATCTCTGCTGAACTAGCTATTGCTACTGCCTGTAAAACCTTTGTTCCTCATCGCAGCAGTTGTTTTGAACTCTATGGCTT
TGACGTGCTCATAGATTCTACTCTGAAGCCATGGTTGTTGGAAGTGAATCTCTCTCCTTCTTTGGCCTGTGATGCGCCTCTGGACCTAAA
GATTAAAGCCAGTATGATTTCAGATATGTTCACTGTTGTAGGATTTGTGTGCCAAGATCCTGCCCAGCGGGCATCAACTCGGCCAATTTA
TCCCACCTTTGAGTCTTCCAGGCGAAACCCTTTCCAGAAACCTCAGCGTTGCCGTCCACTCTCTGCCAGTGATGCGGAAATGAAAAACCT
CGTGGGCTCAGCCCGGGAGAAAGGGCCAGGGAAGTTGGGTGGTTCTGTGCTTGGTCTGTCAATGGAGGAGATCAAAGTTTTACGAAGGGT
GAAGGAGGAGAATGATCGGCGAGGTGGATTTATTCGCATATTTCCTACATCTGAGACATGGGAAATATATGGGTCCTACCTCGAGCATAA
GACCTCAATGAACTATATGCTGGCAACACGCCTCTTCCAGGACAGAATGACTGCTGATGGAGCGCCAGAATTGAAGATAGAGAGTCTGAA
TTCAAAGGCCAAGCTGCATGCTGCACTTTACGAGAGGAAGCTCCTGTCTCTGGAGGTGCGAAAACGTAGACGACGGAGTAGCAGATTGAG
GGCAATGAGGCCAAAATACCCAGTGATTACCCAACCAGCTGAAATGAATGTTAAAACTGAGACAGAGAGTGAAGAGGAGGAAGAAGTCGC
ATTAGATAATGAAGATGAAGAACAGGAGGCTTCCCAGGAGGAGTCTGCAGGATTTCTTAGAGAAAATCAAGCCAAATATACACCCTCATT
GACAGCTTTGGTAGAAAATACACCCAAAGAAAATTCCATGAAAGTTCGTGAATGGAATAATAAAGGTGGACACTGCTGCAAACTTGAGAC
TCAGGAGCTAGAGCCTAAATTTAACCTGATGCAGATTCTTCAAGATAATGGCAATCTTAGCAAAATGCAGGCCCGAATAGCATTCTCTGC
CTATCTCCAGCATGTTCAAATTCGCCTGATGAAAGACAGTGGCGGTCAGACGTTCAGTGCCAGTTGGGCTGCCAAAGAGGATGAACAGAT
GGAGCTGGTTGTTCGTTTCCTCAAGCGAGCATCAAATAACCTCCAGCATTCACTGAGGATGGTATTACCCAGTCGACGATTGGCACTTCT
GGAACGCAGAAGAATCCTGGCCCACCAGCTGGGTGACTTTATCATTGTATACAACAAGGAAACAGAACAAATGGCTGAAAAGAAATCAAA
GAAGAAAGTTGAGGAAGAAGAGGAAGATGGGGTGAATATGGAAAACTTTCAGGAGTTCATCAGACAAGCAAGTGAGGCTGAACTGGAGGA
GGTGTTGACTTTTTATACCCAAAAGAACAAGTCTGCTAGTGTCTTCCTGGGGACTCACTCTAAAATTTCTAAGAACAACAACAATTATTC
TGATAGTGGGGCAAAAGGTGATCACCCTGAGACTATAATGGAAGAAGTGAAAATAAAGCCACCTAAACAGCAACAGACGACAGAAATTCA
TTCTGATAAATTATCTCGATTTACCACTTCAGCAGAAAAAGAGGCAAAATTAGTTTATAGCAATTCCTCCTCTGGTCCTACTGCTACTCT
GCAGAAAATTCCCAACACCCATTTGTCATCTGTTACAACCTCTGACCTCTCTCCAGGGCCTTGCCACCATTCTTCTTTATCTCAAATTCC
TTCAGCTATCCCCAGCATGCCTCACCAGCCAACAATTTTACTGAACACAGTCTCTGCCAGTGCTTCTCCCTGCCTACATCCCGGGGCACA
GAACATCCCAAGCCCTACTGGCCTGCCACGCTGTCGATCAGGAAGTCACACCATTGGTCCCTTTTCTTCCTTCCAAAGTGCTGCACACAT
CTATAGCCAGAAACTGTCTCGTCCCTCTTCAGCAAAGGCAGGATCGTGCTATCTAAACAAGCATCATTCAGGAATAGCCAAAACACAAAA
AGAGGGAGAAGATGCTTCTTTATATAGCAAACGGTACAACCAAAGTATGGTTACAGCTGAACTTCAGCGGCTAGCTGAGAAGCAGGCAGC
GAGACAGTATTCTCCATCCAGCCACATCAACCTCCTCACCCAACAGATCACAGATTCTGCTGGCCATATTCTCTACTCCAAAGAGGATGC
AACCAAGGGGAAATTTGCCTTTACCACTGAAGATTATGACATGTTTGAAGTGTGTTTTGAGAGCAAGGGAACAGGGCGGATACCTGACCA
ACTCGTGATCCTAGACATGAAGCATGGAGTGGAGGCGAAAAATTACGAAGAGATTGCAAAAGTTGAGAAGCTCAAACCATTAGAGGTAGA
GCTGCGACGCCTAGAAGACCTTTCAGAATCTATTGTTAATGATTTTGCCTACATGAAGAAGAGAGAAGAGGAGATGCGTGATACCAACGA
GTCAACAAACACTCGGGTCCTATACTTCAGCATCTTTTCAATGTTCTGTCTCATTGGACTAGCTACCTGGCAGGTCTTCTACCTGCGACG
CTTCTTCAAGGCCAAGAAATTGATTGAGTAATGAATGAGGCATATTCTCCTCCCACCTTGTACCTCAGCCAGCAGAACATCGCTGGGACG
TGCCTGGCCTAAGGCATCCTACCAACAGCACCATCAAGGCACGTTGGAGCTTTCTTGCCAGAACTGATCTCTTTTGGTGTGGGAGGACAT
GGGGTACCACCTACACCCAACAAGTCAATGAGGGACTTCTTTTTAATTTGGTAGGATTTTGACTGGTTTTGCAACAATAGGTCTATTATT
AGAGTCACCTATGACAAAAAATAGGGGTTACCTAGATAATGCCAAAGTCAGCATTTGTCCTGGGTTCCCTTGTGTGATCTGTTTGGACTA
TGTTTTCTTTTCTTCTCCCACTTGCTCAGCAGCTTGGGCTTCCATTCTAGTTCTTTTACCAAGATTTTTGTGTGACCATGTTGACTTCAT
TTGGATTGCCCTCTTTCAATTTCCTTGTGAAAACACCCTTAACTTTCTCTTTACCCTTAGCTGAAATGTTTACATAGCTTCTGGTGATAT
CTTTTCATGATTTTATATCTCTTAAAATGGTGATGGATGTGACACCTCATAAAAGTGAGCTTTGAACTGTAGATAACTCTTAAAGAAAAT
GTCATTTTAGACAATTAAAATATTTGTGCTCAACTGCTTGAACTTTTTTCGTGTATGTGTATTTAATTCTATGCAATATTATCACATGTG
TAGATTCATGTGACCACCATCACAAGAGACAGAACAGTTCTGTCACATGGATCCCTTGCACTGCCCTTTTACAGCCGCAGCCACATCCCT
TTCTTATACCCTCACCCCAACCTGTGGCTACCACTGTTCTGTCCTCCATCTCTGTAATTTTGTCATTTCAAGAATGTTGTATGAATGGAA
TCATACAGAATGTAATCTTACGAGGCTGATCTTTTTTCATTCAGCATAATTCCCTTGAAATCCATCCAAGTTGTTGCATGTATGAATAGT
TTCTTCCTTTTTTTCTTTTAAAAATGTTTTATATATTTAGGGGGTATAAGTACAGATTTCTTACATGCATATATTGCATCGTGGTGAAGT
GGGGGCAGTTCCTTTTGATTGCTGAGTAGTATTCCATGGTATGGATGTACCACAGTTTGCTTAACCATTCACCCACTAAAGGACATAAGA
GTTGTTTTCAGTTTTTTGCCCTAATAAAGCTGCTGTGAACATTCATGTACAGGTTTTTATGTGAACATACATTTTCATTTTCTGGGATAA
ATGCTCAAAAGGGCAACTGTTGGGTTGTATGGTAAACACATATATTTTTGTAAGAAACTACCCTACTCTTTTTCCAGAGTGGCTCTACTT
TTTACATACAGCCACTCATACAATTCAGACAGCAATGTATGATTGATCCAGTTTCTTCACATCCTCACCAGCATTTGGTATTACTACTAT
TTTTTATCTTAACCATTCACATAGATGTGTGTAATGATACCACATGTGGTTTTAATTTGCATTTCCAATGGCTAATGATGTTGAGTATCT
TTTTGTGTGCTAATTTGCCATCTATGTATCCTCTTCGGTGAAATGTCTTCATGTCTTTTGTCTATTTTCTATTTAGGTCATTTGTTCTTT
TTACTATTGAGTTTTGAGAGGTTTTTTATATATCCTAGATAAAATTCCTCTGTTAGATATGTGGTTGCTTGAATTTTTAACATAACTTCT
ACCAAGGAAAAATAAGTAAAATTTCCAACCCTTGCATGGCCAGTCACTTACTTAATTCCTGTCCTTCAGTGTTCCATCTAGAGAATTAAG
AGATATGATGTATAAAATAGACATCGAGGGCCATTAAGAGAGTAAATACTTAAAAATACATGTTATGAAAGCAAAGCCAATAATCACTGT
AGGAGTATGAGTTGCCTAAGGGCCAAAACTAATGTAAATAAGAGAAAGTGTGGATATAAATGACCATTGTTTATAAACAGTTATGAAAAA
TGCTGTGACTTGAAATCTTTCCCACATCTCCCAAGAAAGTAGGTAGGAGTTTATCCTTTCCGTAATCTCTTTTTAACCCTGCTGACTATT
ACAGGGCTTGTTTAATCACAGTGGCAAGAATTACATGTATCTTACAGTAAAGAAACAGAATACTGGAATCGTTAGAGAACCCTGATGTGT
TGACCTGGATAAAGTACAAAGGTGGAAGAGGGAATGAGTTATGCTGTTAAAATCTCAGGCTATTCTGTTAATGTTCCTGCTACTATGAAC
CCAAACTTTTTTTTTCCCCCTTTTGACTCCTTGTGTCTTCCTCTCCTGTGGCATAAAAGTAGTTCTGTCGTTAACTTGTACAACATTGCC
ATCTGCTGTTGAGAATTGGTAGGTACTGCTTCTGAGAACCTGGCTGCAGATCCTTAGCATAGGCAGCAAATGTTGAGAAAGTCTATCTGT
AGTATTACATATACTAAGTTACAGAGGATGCATCCAAGTAGAGAAAATAATATGTGGGTTAAGATACATCCTTAAACTTTTTTTTTTTTG
GGGGGGGGGGGACGGAGTCTTGCTGCAACGCCCAGGCTGGAGTGCAATGGCACTATCTCAGCTCGCTGCAACCTTCACCTCCTGGGTTCA
AGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAATATAGGTGCACACCACCATGCCTGGCTAATTTTTGTATTTTCAGTAGAAGCA
GAGTTTCACCATATTGGCCAGGTTGGTCTCGAACTCCTGACCTCAAGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGC
GTGAGCCACCACACCCAGCCTCCATCTTTAAACTTTTAAATGTGAAATTTCTATCATGTACCGTTAGCCTAACAAGATTTTCTTTCCTAT
TTCTGACTGGTGCCTTTCCCCTTTTTAGGAGCAACGAAAGCTACTCTCTTAGTTATGTTCTTGTGATGTGACAAAATGTCAAGAAGATAG
GAGAAGAGAATATTTTATTTCGTTGATGCTTTTGTTCCCAAGTGTGACCCTAAACTTAAGCTTTGTAGGAGTTGACATTCTTTCATGTCC
CTTCCCTTTACTCATGCCGAAACTATCAACTGGGACATTTTGTGCTTTTGGTTTAAAAGTTAATTGATATTATACTTTGGTTTTATCTAA
AAAGTAAATGTATTTGCCTTTGACAAAAGACTGACACAAGAGCAAATAAGCTTTAAAATCGGGTGTTATGTGCTTTCCTCCATTTTTGAG
CATATTATCCAAAATGGTCTGTATAATATAAATGAGAATGATGCAGTTTAAGTAAGCCTTGTTATACCATTGTCATGGACCCCTGTCATA
AAGCCATTTCTTGGTTTGTTTGGGAAAGAGGCATATGGGATTTATACAGATTCACTTGTAAATGTTGGATTGGGGATTTTTGTGTAAATT

>In-frame_ENST00000298832_ENST00000303575_TCGA-CV-6961-01A_TTLL5_chr14_76259443_+_TMED10_chr14_75618846_length(amino acids)=1201AA_start in transcript=205_stop in transcript=3810
MPIVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVFHADAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVH
PSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVK
PVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNY
SVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDSTL
KPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRCRPLSASDAEMKNLVGSAREKG
PGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRMTADGAPELKIESLNSKAKLHAA
LYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTPSLTALVENTP
KENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDEQMELVVRFLK
RASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAELEEVLTFYTQK
NKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTATLQKIPNTHL
SSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSFQSAAHIYSQKLSRP
SSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQITDSAGHILYSKEDATKGKFAFT
TEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLY

--------------------------------------------------------------
>In-frame_ENST00000556893_ENST00000303575_TCGA-CV-6961-01A_TTLL5_chr14_76259443_+_TMED10_chr14_75618846_length(transcript)=5744nt_BP=1894nt
GAAAAACCTCGTGGGCTCAGCCCGGGAGAAAGGGCCAGGGAAGTTGGGTGGTTCTGTGCTTGGTCTGTCAATGGAGGAGATCAAAGTTTT
ACGAAGGGTGAAGGAGGAGAATGATCGGCGAGGTGGATTTATTCGCATATTTCCTACATCTGAGACATGGGAAATATATGGGTCCTACCT
CGAGCATAAGACCTCAATGAACTATATGCTGGCAACACGCCTCTTCCAGGACAGGGGAAACCCAAGAAGAAGCTTATTGACAGGAAGAAC
ACGAATGACTGCTGATGGAGCGCCAGAATTGAAGATAGAGAGTCTGAATTCAAAGGCCAAGCTGCATGCTGCACTTTACGAGAGGAAGCT
CCTGTCTCTGGAGGTGCGAAAACGTAGACGACGGAGTAGCAGATTGAGGGCAATGAGGCCAAAATACCCAGTGATTACCCAACCAGCTGA
AATGAATGTTAAAACTGAGACAGAGAGTGAAGAGGAGGAAGAAGTCGCATTAGATAATGAAGATGAAGAACAGGAGGCTTCCCAGGAGGA
GTCTGCAGGATTTCTTAGAGAAAATCAAGCCAAATATACACCCTCATTGACAGCTTTGGTAGAAAATACACCCAAAGAAAATTCCATGAA
AGTTCGTGAATGGAATAATAAAGGTGGACACTGCTGCAAACTTGAGACTCAGGAGCTAGAGCCTAAATTTAACCTGATGCAGATTCTTCA
AGATAATGGCAATCTTAGCAAAATGCAGGCCCGAATAGCATTCTCTGCCTATCTCCAGCATGTTCAAATTCGCCTGATGAAAGACAGTGG
CGGTCAGACGTTCAGTGCCAGTTGGGCTGCCAAAGAGGATGAACAGATGGAGCTGGTTGTTCGTTTCCTCAAGCGAGCATCAAATAACCT
CCAGCATTCACTGAGGATGGTATTACCCAGTCGACGATTGGCACTTCTGGAACGCAGAAGAATCCTGGCCCACCAGCTGGGTGACTTTAT
CATTGTATACAACAAGGAAACAGAACAAATGGCTGAAAAGAAATCAAAGAAGAAAGTTGAGGAAGAAGAGGAAGATGGGGTGAATATGGA
AAACTTTCAGGAGTTCATCAGACAAGCAAGTGAGGCTGAACTGGAGGAGGTGTTGACTTTTTATACCCAAAAGAACAAGTCTGCTAGTGT
CTTCCTGGGGACTCACTCTAAAATTTCTAAGAACAACAACAATTATTCTGATAGTGGGGCAAAAGGTGATCACCCTGAGACTATAATGGA
AGAAGTGAAAATAAAGCCACCTAAACAGCAACAGACGACAGAAATTCATTCTGATAAATTATCTCGATTTACCACTTCAGCAGAAAAAGA
GGCAAAATTAGTTTATAGCAATTCCTCCTCTGGTCCTACTGCTACTCTGCAGAAAATTCCCAACACCCATTTGTCATCTGTTACAACCTC
TGACCTCTCTCCAGGGCCTTGCCACCATTCTTCTTTATCTCAAATTCCTTCAGCTATCCCCAGCATGCCTCACCAGCCAACAATTTTACT
GAACACAGTCTCTGCCAGTGCTTCTCCCTGCCTACATCCCGGGGCACAGAACATCCCAAGCCCTACTGGCCTGCCACGCTGTCGATCAGG
AAGTCACACCATTGGTCCCTTTTCTTCCTTCCAAAGTGCTGCACACATCTATAGCCAGAAACTGTCTCGTCCCTCTTCAGCAAAGGCAGG
ATCGTGCTATCTAAACAAGCATCATTCAGGAATAGCCAAAACACAAAAAGAGGGAGAAGATGCTTCTTTATATAGCAAACGGTACAACCA
AAGTATGGTTACAGCTGAACTTCAGCGGCTAGCTGAGAAGCAGGCAGCGAGACAGTATTCTCCATCCAGCCACATCAACCTCCTCACCCA
ACAGATCACAGATTCTGCTGGCCATATTCTCTACTCCAAAGAGGATGCAACCAAGGGGAAATTTGCCTTTACCACTGAAGATTATGACAT
GTTTGAAGTGTGTTTTGAGAGCAAGGGAACAGGGCGGATACCTGACCAACTCGTGATCCTAGACATGAAGCATGGAGTGGAGGCGAAAAA
TTACGAAGAGATTGCAAAAGTTGAGAAGCTCAAACCATTAGAGGTAGAGCTGCGACGCCTAGAAGACCTTTCAGAATCTATTGTTAATGA
TTTTGCCTACATGAAGAAGAGAGAAGAGGAGATGCGTGATACCAACGAGTCAACAAACACTCGGGTCCTATACTTCAGCATCTTTTCAAT
GTTCTGTCTCATTGGACTAGCTACCTGGCAGGTCTTCTACCTGCGACGCTTCTTCAAGGCCAAGAAATTGATTGAGTAATGAATGAGGCA
TATTCTCCTCCCACCTTGTACCTCAGCCAGCAGAACATCGCTGGGACGTGCCTGGCCTAAGGCATCCTACCAACAGCACCATCAAGGCAC
GTTGGAGCTTTCTTGCCAGAACTGATCTCTTTTGGTGTGGGAGGACATGGGGTACCACCTACACCCAACAAGTCAATGAGGGACTTCTTT
TTAATTTGGTAGGATTTTGACTGGTTTTGCAACAATAGGTCTATTATTAGAGTCACCTATGACAAAAAATAGGGGTTACCTAGATAATGC
CAAAGTCAGCATTTGTCCTGGGTTCCCTTGTGTGATCTGTTTGGACTATGTTTTCTTTTCTTCTCCCACTTGCTCAGCAGCTTGGGCTTC
CATTCTAGTTCTTTTACCAAGATTTTTGTGTGACCATGTTGACTTCATTTGGATTGCCCTCTTTCAATTTCCTTGTGAAAACACCCTTAA
CTTTCTCTTTACCCTTAGCTGAAATGTTTACATAGCTTCTGGTGATATCTTTTCATGATTTTATATCTCTTAAAATGGTGATGGATGTGA
CACCTCATAAAAGTGAGCTTTGAACTGTAGATAACTCTTAAAGAAAATGTCATTTTAGACAATTAAAATATTTGTGCTCAACTGCTTGAA
CTTTTTTCGTGTATGTGTATTTAATTCTATGCAATATTATCACATGTGTAGATTCATGTGACCACCATCACAAGAGACAGAACAGTTCTG
TCACATGGATCCCTTGCACTGCCCTTTTACAGCCGCAGCCACATCCCTTTCTTATACCCTCACCCCAACCTGTGGCTACCACTGTTCTGT
CCTCCATCTCTGTAATTTTGTCATTTCAAGAATGTTGTATGAATGGAATCATACAGAATGTAATCTTACGAGGCTGATCTTTTTTCATTC
AGCATAATTCCCTTGAAATCCATCCAAGTTGTTGCATGTATGAATAGTTTCTTCCTTTTTTTCTTTTAAAAATGTTTTATATATTTAGGG
GGTATAAGTACAGATTTCTTACATGCATATATTGCATCGTGGTGAAGTGGGGGCAGTTCCTTTTGATTGCTGAGTAGTATTCCATGGTAT
GGATGTACCACAGTTTGCTTAACCATTCACCCACTAAAGGACATAAGAGTTGTTTTCAGTTTTTTGCCCTAATAAAGCTGCTGTGAACAT
TCATGTACAGGTTTTTATGTGAACATACATTTTCATTTTCTGGGATAAATGCTCAAAAGGGCAACTGTTGGGTTGTATGGTAAACACATA
TATTTTTGTAAGAAACTACCCTACTCTTTTTCCAGAGTGGCTCTACTTTTTACATACAGCCACTCATACAATTCAGACAGCAATGTATGA
TTGATCCAGTTTCTTCACATCCTCACCAGCATTTGGTATTACTACTATTTTTTATCTTAACCATTCACATAGATGTGTGTAATGATACCA
CATGTGGTTTTAATTTGCATTTCCAATGGCTAATGATGTTGAGTATCTTTTTGTGTGCTAATTTGCCATCTATGTATCCTCTTCGGTGAA
ATGTCTTCATGTCTTTTGTCTATTTTCTATTTAGGTCATTTGTTCTTTTTACTATTGAGTTTTGAGAGGTTTTTTATATATCCTAGATAA
AATTCCTCTGTTAGATATGTGGTTGCTTGAATTTTTAACATAACTTCTACCAAGGAAAAATAAGTAAAATTTCCAACCCTTGCATGGCCA
GTCACTTACTTAATTCCTGTCCTTCAGTGTTCCATCTAGAGAATTAAGAGATATGATGTATAAAATAGACATCGAGGGCCATTAAGAGAG
TAAATACTTAAAAATACATGTTATGAAAGCAAAGCCAATAATCACTGTAGGAGTATGAGTTGCCTAAGGGCCAAAACTAATGTAAATAAG
AGAAAGTGTGGATATAAATGACCATTGTTTATAAACAGTTATGAAAAATGCTGTGACTTGAAATCTTTCCCACATCTCCCAAGAAAGTAG
GTAGGAGTTTATCCTTTCCGTAATCTCTTTTTAACCCTGCTGACTATTACAGGGCTTGTTTAATCACAGTGGCAAGAATTACATGTATCT
TACAGTAAAGAAACAGAATACTGGAATCGTTAGAGAACCCTGATGTGTTGACCTGGATAAAGTACAAAGGTGGAAGAGGGAATGAGTTAT
GCTGTTAAAATCTCAGGCTATTCTGTTAATGTTCCTGCTACTATGAACCCAAACTTTTTTTTTCCCCCTTTTGACTCCTTGTGTCTTCCT
CTCCTGTGGCATAAAAGTAGTTCTGTCGTTAACTTGTACAACATTGCCATCTGCTGTTGAGAATTGGTAGGTACTGCTTCTGAGAACCTG
GCTGCAGATCCTTAGCATAGGCAGCAAATGTTGAGAAAGTCTATCTGTAGTATTACATATACTAAGTTACAGAGGATGCATCCAAGTAGA
GAAAATAATATGTGGGTTAAGATACATCCTTAAACTTTTTTTTTTTTGGGGGGGGGGGGACGGAGTCTTGCTGCAACGCCCAGGCTGGAG
TGCAATGGCACTATCTCAGCTCGCTGCAACCTTCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAATATA
GGTGCACACCACCATGCCTGGCTAATTTTTGTATTTTCAGTAGAAGCAGAGTTTCACCATATTGGCCAGGTTGGTCTCGAACTCCTGACC
TCAAGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGCGTGAGCCACCACACCCAGCCTCCATCTTTAAACTTTTAAATG
TGAAATTTCTATCATGTACCGTTAGCCTAACAAGATTTTCTTTCCTATTTCTGACTGGTGCCTTTCCCCTTTTTAGGAGCAACGAAAGCT
ACTCTCTTAGTTATGTTCTTGTGATGTGACAAAATGTCAAGAAGATAGGAGAAGAGAATATTTTATTTCGTTGATGCTTTTGTTCCCAAG
TGTGACCCTAAACTTAAGCTTTGTAGGAGTTGACATTCTTTCATGTCCCTTCCCTTTACTCATGCCGAAACTATCAACTGGGACATTTTG
TGCTTTTGGTTTAAAAGTTAATTGATATTATACTTTGGTTTTATCTAAAAAGTAAATGTATTTGCCTTTGACAAAAGACTGACACAAGAG
CAAATAAGCTTTAAAATCGGGTGTTATGTGCTTTCCTCCATTTTTGAGCATATTATCCAAAATGGTCTGTATAATATAAATGAGAATGAT
GCAGTTTAAGTAAGCCTTGTTATACCATTGTCATGGACCCCTGTCATAAAGCCATTTCTTGGTTTGTTTGGGAAAGAGGCATATGGGATT

>In-frame_ENST00000556893_ENST00000303575_TCGA-CV-6961-01A_TTLL5_chr14_76259443_+_TMED10_chr14_75618846_length(amino acids)=761AA_start in transcript=43_stop in transcript=2328
MGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRGNPRRSLLTGRTRMTADGAPELKIES
LNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTP
SLTALVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDE
QMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAEL
EEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTA
TLQKIPNTHLSSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSFQSAA
HIYSQKLSRPSSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQITDSAGHILYSKE
DATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDT

--------------------------------------------------------------
>In-frame_ENST00000554510_ENST00000303575_TCGA-CV-6961-01A_TTLL5_chr14_76259443_+_TMED10_chr14_75618846_length(transcript)=5667nt_BP=1817nt
AGATCAAAGTTTTACGAAGGGTGAAGGAGGAGAATGATCGGCGAGGTGGATTTATTCGCATATTTCCTACATCTGAGACATGGGAAATAT
ATGGGTCCTACCTCGAGCATAAGACCTCAATGAACTATATGCTGGCAACACGCCTCTTCCAGGACAGGGGAAACCCAAGAAGAAGCTTAT
TGACAGGAAGAACACGAATGACTGCTGATGGAGCGCCAGAATTGAAGATAGAGAGTCTGAATTCAAAGGCCAAGCTGCATGCTGCACTTT
ACGAGAGGAAGCTCCTGTCTCTGGAGGTGCGAAAACGTAGACGACGGAGTAGCAGATTGAGGGCAATGAGGCCAAAATACCCAGTGATTA
CCCAACCAGCTGAAATGAATGTTAAAACTGAGACAGAGAGTGAAGAGGAGGAAGAAGTCGCATTAGATAATGAAGATGAAGAACAGGAGG
CTTCCCAGGAGGAGTCTGCAGGATTTCTTAGAGAAAATCAAGCCAAATATACACCCTCATTGACAGCTTTGGTAGAAAATACACCCAAAG
AAAATTCCATGAAAGTTCGTGAATGGAATAATAAAGGTGGACACTGCTGCAAACTTGAGACTCAGGAGCTAGAGCCTAAATTTAACCTGA
TGCAGATTCTTCAAGATAATGGCAATCTTAGCAAAATGCAGGCCCGAATAGCATTCTCTGCCTATCTCCAGCATGTTCAAATTCGCCTGA
TGAAAGACAGTGGCGGTCAGACGTTCAGTGCCAGTTGGGCTGCCAAAGAGGATGAACAGATGGAGCTGGTTGTTCGTTTCCTCAAGCGAG
CATCAAATAACCTCCAGCATTCACTGAGGATGGTATTACCCAGTCGACGATTGGCACTTCTGGAACGCAGAAGAATCCTGGCCCACCAGC
TGGGTGACTTTATCATTGTATACAACAAGGAAACAGAACAAATGGCTGAAAAGAAATCAAAGAAGAAAGTTGAGGAAGAAGAGGAAGATG
GGGTGAATATGGAAAACTTTCAGGAGTTCATCAGACAAGCAAGTGAGGCTGAACTGGAGGAGGTGTTGACTTTTTATACCCAAAAGAACA
AGTCTGCTAGTGTCTTCCTGGGGACTCACTCTAAAATTTCTAAGAACAACAACAATTATTCTGATAGTGGGGCAAAAGGTGATCACCCTG
AGACTATAATGGAAGAAGTGAAAATAAAGCCACCTAAACAGCAACAGACGACAGAAATTCATTCTGATAAATTATCTCGATTTACCACTT
CAGCAGAAAAAGAGGCAAAATTAGTTTATAGCAATTCCTCCTCTGGTCCTACTGCTACTCTGCAGAAAATTCCCAACACCCATTTGTCAT
CTGTTACAACCTCTGACCTCTCTCCAGGGCCTTGCCACCATTCTTCTTTATCTCAAATTCCTTCAGCTATCCCCAGCATGCCTCACCAGC
CAACAATTTTACTGAACACAGTCTCTGCCAGTGCTTCTCCCTGCCTACATCCCGGGGCACAGAACATCCCAAGCCCTACTGGCCTGCCAC
GCTGTCGATCAGGAAGTCACACCATTGGTCCCTTTTCTTCCTTCCAAAGTGCTGCACACATCTATAGCCAGAAACTGTCTCGTCCCTCTT
CAGCAAAGGCAGGATCGTGCTATCTAAACAAGCATCATTCAGGAATAGCCAAAACACAAAAAGAGGGAGAAGATGCTTCTTTATATAGCA
AACGGTACAACCAAAGTATGGTTACAGCTGAACTTCAGCGGCTAGCTGAGAAGCAGGCAGCGAGACAGTATTCTCCATCCAGCCACATCA
ACCTCCTCACCCAACAGATCACAGATTCTGCTGGCCATATTCTCTACTCCAAAGAGGATGCAACCAAGGGGAAATTTGCCTTTACCACTG
AAGATTATGACATGTTTGAAGTGTGTTTTGAGAGCAAGGGAACAGGGCGGATACCTGACCAACTCGTGATCCTAGACATGAAGCATGGAG
TGGAGGCGAAAAATTACGAAGAGATTGCAAAAGTTGAGAAGCTCAAACCATTAGAGGTAGAGCTGCGACGCCTAGAAGACCTTTCAGAAT
CTATTGTTAATGATTTTGCCTACATGAAGAAGAGAGAAGAGGAGATGCGTGATACCAACGAGTCAACAAACACTCGGGTCCTATACTTCA
GCATCTTTTCAATGTTCTGTCTCATTGGACTAGCTACCTGGCAGGTCTTCTACCTGCGACGCTTCTTCAAGGCCAAGAAATTGATTGAGT
AATGAATGAGGCATATTCTCCTCCCACCTTGTACCTCAGCCAGCAGAACATCGCTGGGACGTGCCTGGCCTAAGGCATCCTACCAACAGC
ACCATCAAGGCACGTTGGAGCTTTCTTGCCAGAACTGATCTCTTTTGGTGTGGGAGGACATGGGGTACCACCTACACCCAACAAGTCAAT
GAGGGACTTCTTTTTAATTTGGTAGGATTTTGACTGGTTTTGCAACAATAGGTCTATTATTAGAGTCACCTATGACAAAAAATAGGGGTT
ACCTAGATAATGCCAAAGTCAGCATTTGTCCTGGGTTCCCTTGTGTGATCTGTTTGGACTATGTTTTCTTTTCTTCTCCCACTTGCTCAG
CAGCTTGGGCTTCCATTCTAGTTCTTTTACCAAGATTTTTGTGTGACCATGTTGACTTCATTTGGATTGCCCTCTTTCAATTTCCTTGTG
AAAACACCCTTAACTTTCTCTTTACCCTTAGCTGAAATGTTTACATAGCTTCTGGTGATATCTTTTCATGATTTTATATCTCTTAAAATG
GTGATGGATGTGACACCTCATAAAAGTGAGCTTTGAACTGTAGATAACTCTTAAAGAAAATGTCATTTTAGACAATTAAAATATTTGTGC
TCAACTGCTTGAACTTTTTTCGTGTATGTGTATTTAATTCTATGCAATATTATCACATGTGTAGATTCATGTGACCACCATCACAAGAGA
CAGAACAGTTCTGTCACATGGATCCCTTGCACTGCCCTTTTACAGCCGCAGCCACATCCCTTTCTTATACCCTCACCCCAACCTGTGGCT
ACCACTGTTCTGTCCTCCATCTCTGTAATTTTGTCATTTCAAGAATGTTGTATGAATGGAATCATACAGAATGTAATCTTACGAGGCTGA
TCTTTTTTCATTCAGCATAATTCCCTTGAAATCCATCCAAGTTGTTGCATGTATGAATAGTTTCTTCCTTTTTTTCTTTTAAAAATGTTT
TATATATTTAGGGGGTATAAGTACAGATTTCTTACATGCATATATTGCATCGTGGTGAAGTGGGGGCAGTTCCTTTTGATTGCTGAGTAG
TATTCCATGGTATGGATGTACCACAGTTTGCTTAACCATTCACCCACTAAAGGACATAAGAGTTGTTTTCAGTTTTTTGCCCTAATAAAG
CTGCTGTGAACATTCATGTACAGGTTTTTATGTGAACATACATTTTCATTTTCTGGGATAAATGCTCAAAAGGGCAACTGTTGGGTTGTA
TGGTAAACACATATATTTTTGTAAGAAACTACCCTACTCTTTTTCCAGAGTGGCTCTACTTTTTACATACAGCCACTCATACAATTCAGA
CAGCAATGTATGATTGATCCAGTTTCTTCACATCCTCACCAGCATTTGGTATTACTACTATTTTTTATCTTAACCATTCACATAGATGTG
TGTAATGATACCACATGTGGTTTTAATTTGCATTTCCAATGGCTAATGATGTTGAGTATCTTTTTGTGTGCTAATTTGCCATCTATGTAT
CCTCTTCGGTGAAATGTCTTCATGTCTTTTGTCTATTTTCTATTTAGGTCATTTGTTCTTTTTACTATTGAGTTTTGAGAGGTTTTTTAT
ATATCCTAGATAAAATTCCTCTGTTAGATATGTGGTTGCTTGAATTTTTAACATAACTTCTACCAAGGAAAAATAAGTAAAATTTCCAAC
CCTTGCATGGCCAGTCACTTACTTAATTCCTGTCCTTCAGTGTTCCATCTAGAGAATTAAGAGATATGATGTATAAAATAGACATCGAGG
GCCATTAAGAGAGTAAATACTTAAAAATACATGTTATGAAAGCAAAGCCAATAATCACTGTAGGAGTATGAGTTGCCTAAGGGCCAAAAC
TAATGTAAATAAGAGAAAGTGTGGATATAAATGACCATTGTTTATAAACAGTTATGAAAAATGCTGTGACTTGAAATCTTTCCCACATCT
CCCAAGAAAGTAGGTAGGAGTTTATCCTTTCCGTAATCTCTTTTTAACCCTGCTGACTATTACAGGGCTTGTTTAATCACAGTGGCAAGA
ATTACATGTATCTTACAGTAAAGAAACAGAATACTGGAATCGTTAGAGAACCCTGATGTGTTGACCTGGATAAAGTACAAAGGTGGAAGA
GGGAATGAGTTATGCTGTTAAAATCTCAGGCTATTCTGTTAATGTTCCTGCTACTATGAACCCAAACTTTTTTTTTCCCCCTTTTGACTC
CTTGTGTCTTCCTCTCCTGTGGCATAAAAGTAGTTCTGTCGTTAACTTGTACAACATTGCCATCTGCTGTTGAGAATTGGTAGGTACTGC
TTCTGAGAACCTGGCTGCAGATCCTTAGCATAGGCAGCAAATGTTGAGAAAGTCTATCTGTAGTATTACATATACTAAGTTACAGAGGAT
GCATCCAAGTAGAGAAAATAATATGTGGGTTAAGATACATCCTTAAACTTTTTTTTTTTTGGGGGGGGGGGGACGGAGTCTTGCTGCAAC
GCCCAGGCTGGAGTGCAATGGCACTATCTCAGCTCGCTGCAACCTTCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGT
AGCTGGGAATATAGGTGCACACCACCATGCCTGGCTAATTTTTGTATTTTCAGTAGAAGCAGAGTTTCACCATATTGGCCAGGTTGGTCT
CGAACTCCTGACCTCAAGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGCGTGAGCCACCACACCCAGCCTCCATCTTT
AAACTTTTAAATGTGAAATTTCTATCATGTACCGTTAGCCTAACAAGATTTTCTTTCCTATTTCTGACTGGTGCCTTTCCCCTTTTTAGG
AGCAACGAAAGCTACTCTCTTAGTTATGTTCTTGTGATGTGACAAAATGTCAAGAAGATAGGAGAAGAGAATATTTTATTTCGTTGATGC
TTTTGTTCCCAAGTGTGACCCTAAACTTAAGCTTTGTAGGAGTTGACATTCTTTCATGTCCCTTCCCTTTACTCATGCCGAAACTATCAA
CTGGGACATTTTGTGCTTTTGGTTTAAAAGTTAATTGATATTATACTTTGGTTTTATCTAAAAAGTAAATGTATTTGCCTTTGACAAAAG
ACTGACACAAGAGCAAATAAGCTTTAAAATCGGGTGTTATGTGCTTTCCTCCATTTTTGAGCATATTATCCAAAATGGTCTGTATAATAT
AAATGAGAATGATGCAGTTTAAGTAAGCCTTGTTATACCATTGTCATGGACCCCTGTCATAAAGCCATTTCTTGGTTTGTTTGGGAAAGA

>In-frame_ENST00000554510_ENST00000303575_TCGA-CV-6961-01A_TTLL5_chr14_76259443_+_TMED10_chr14_75618846_length(amino acids)=710AA_start in transcript=119_stop in transcript=2251
MNYMLATRLFQDRGNPRRSLLTGRTRMTADGAPELKIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKT
ETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTPSLTALVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNL
SKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDEQMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNK
ETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAELEEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIK
PPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTATLQKIPNTHLSSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSA
SASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSFQSAAHIYSQKLSRPSSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTA
ELQRLAEKQAARQYSPSSHINLLTQQITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEIA

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Fusion Gene PPI Analysis for TTLL5-TMED10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTMED10chr14:76259443chr14:75618846ENST0000030357505207_21975.0220.0ARF1 and IL1B
TgeneTMED10chr14:76259443chr14:75618846ENST0000030357505204_21975.0220.0COPG1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TTLL5-TMED10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TTLL5-TMED10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTTLL5C4014501CONE-ROD DYSTROPHY 192CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneTTLL5C0087031Juvenile-Onset Still Disease1CTD_human
HgeneTTLL5C3489532Cone-Rod Dystrophy 21ORPHANET
HgeneTTLL5C3495559Juvenile arthritis1CTD_human
HgeneTTLL5C3714758Juvenile psoriatic arthritis1CTD_human
HgeneTTLL5C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneTTLL5C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human