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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TTN-TTN (FusionGDB2 ID:94563)

Fusion Gene Summary for TTN-TTN

Fusion gene summary

Fusion gene information	Fusion gene name: TTN-TTN
	Fusion gene ID: 94563
		Hgene	Tgene
	Gene symbol	TTN	TTN
	Gene ID	7273	7273
	Gene name	titin	titin
	Synonyms	CMD1G\|CMH9\|CMPD4\|EOMFC\|HMERF\|LGMD2J\|LGMDR10\|MYLK5\|SALMY\|TMD	CMD1G\|CMH9\|CMPD4\|EOMFC\|HMERF\|LGMD2J\|LGMDR10\|MYLK5\|SALMY\|TMD
	Cytomap	2q31.2	2q31.2
	Type of gene	protein-coding	protein-coding
	Description	titinconnectinrhabdomyosarcoma antigen MU-RMS-40.14	titinconnectinrhabdomyosarcoma antigen MU-RMS-40.14
	Modification date	20200328	20200328
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000342992, ENST00000460472, ENST00000589042, ENST00000342175, ENST00000359218, ENST00000591111, ENST00000360870,	ENST00000342992, ENST00000460472, ENST00000589042, ENST00000342175, ENST00000359218, ENST00000591111, ENST00000360870,
Fusion gene scores	* DoF score	16 X 18 X 6=1728	7 X 8 X 4=224
	# samples	18	8
	** MAII score	log2(18/1728*10)=-3.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TTN [Title/Abstract] AND TTN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TTN(179612128)-TTN(179610700), # samples:1 TTN(179569672)-TTN(179569323), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TTN	GO:0035995	detection of muscle stretch	18765796
Hgene	TTN	GO:0051592	response to calcium ion	7607248
Tgene	TTN	GO:0035995	detection of muscle stretch	18765796
Tgene	TTN	GO:0051592	response to calcium ion	7607248

Fusion gene breakpoints across TTN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TTN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF824891	TTN	chr2	179612128	-	TTN	chr2	179610700	+
ChiTaRS5.0	N/A	F00774	TTN	chr2	179569672	+	TTN	chr2	179569323	-

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Fusion Gene ORF analysis for TTN-TTN

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000342992	ENST00000342992	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342992	ENST00000460472	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342992	ENST00000589042	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342992	ENST00000342175	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342992	ENST00000359218	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342992	ENST00000591111	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342992	ENST00000360870	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000460472	ENST00000342992	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000460472	ENST00000460472	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000460472	ENST00000589042	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000460472	ENST00000342175	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000460472	ENST00000359218	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000460472	ENST00000591111	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000460472	ENST00000360870	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000589042	ENST00000342992	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000589042	ENST00000460472	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000589042	ENST00000589042	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000589042	ENST00000342175	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000589042	ENST00000359218	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000589042	ENST00000591111	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000589042	ENST00000360870	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342175	ENST00000342992	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342175	ENST00000460472	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342175	ENST00000589042	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342175	ENST00000342175	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342175	ENST00000359218	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342175	ENST00000591111	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000342175	ENST00000360870	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000359218	ENST00000342992	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000359218	ENST00000460472	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000359218	ENST00000589042	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000359218	ENST00000342175	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000359218	ENST00000359218	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000359218	ENST00000591111	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000359218	ENST00000360870	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000591111	ENST00000342992	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000591111	ENST00000460472	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000591111	ENST00000589042	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000591111	ENST00000342175	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000591111	ENST00000359218	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000591111	ENST00000591111	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000591111	ENST00000360870	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000360870	ENST00000342992	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000360870	ENST00000460472	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000360870	ENST00000589042	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000360870	ENST00000342175	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000360870	ENST00000359218	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000360870	ENST00000591111	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-intron	ENST00000360870	ENST00000360870	TTN	chr2	179612128	-	TTN	chr2	179610700	+
intron-3CDS	ENST00000342992	ENST00000342992	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000342992	ENST00000460472	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000342992	ENST00000589042	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000342992	ENST00000342175	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000342992	ENST00000359218	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000342992	ENST00000591111	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000342992	ENST00000360870	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-3CDS	ENST00000460472	ENST00000342992	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000460472	ENST00000460472	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000460472	ENST00000589042	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000460472	ENST00000342175	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000460472	ENST00000359218	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000460472	ENST00000591111	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000460472	ENST00000360870	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-3CDS	ENST00000589042	ENST00000342992	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000589042	ENST00000460472	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000589042	ENST00000589042	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000589042	ENST00000342175	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000589042	ENST00000359218	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000589042	ENST00000591111	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000589042	ENST00000360870	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-3CDS	ENST00000342175	ENST00000342992	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000342175	ENST00000460472	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000342175	ENST00000589042	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000342175	ENST00000342175	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000342175	ENST00000359218	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000342175	ENST00000591111	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000342175	ENST00000360870	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-3CDS	ENST00000359218	ENST00000342992	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000359218	ENST00000460472	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000359218	ENST00000589042	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000359218	ENST00000342175	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000359218	ENST00000359218	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000359218	ENST00000591111	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000359218	ENST00000360870	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-3CDS	ENST00000591111	ENST00000342992	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000591111	ENST00000460472	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000591111	ENST00000589042	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000591111	ENST00000342175	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000591111	ENST00000359218	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000591111	ENST00000591111	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000591111	ENST00000360870	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-3CDS	ENST00000360870	ENST00000342992	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000360870	ENST00000460472	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000360870	ENST00000589042	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000360870	ENST00000342175	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000360870	ENST00000359218	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000360870	ENST00000591111	TTN	chr2	179569672	+	TTN	chr2	179569323	-
intron-intron	ENST00000360870	ENST00000360870	TTN	chr2	179569672	+	TTN	chr2	179569323	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for TTN-TTN

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TTN-TTN

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for TTN-TTN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TTN-TTN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TTN-TTN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TTN-TTN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TTN	C0007194	Hypertrophic Cardiomyopathy	9	CLINGEN
Hgene	TTN	C1858763	Cardiomyopathy, Dilated, 1g	7	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	TTN	C1861065	CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 9	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	TTN	C1863599	Hereditary Myopathy with Early Respiratory Failure	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	TTN	C2673677	Myopathy, Early-Onset, with Fatal Cardiomyopathy	5	CTD_human;GENOMICS_ENGLAND;ORPHANET
Hgene	TTN	C0007193	Cardiomyopathy, Dilated	4	CTD_human;GENOMICS_ENGLAND
Hgene	TTN	C1838244	TIBIAL MUSCULAR DYSTROPHY, TARDIVE	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	TTN	C1449563	Cardiomyopathy, Familial Idiopathic	3	CTD_human
Hgene	TTN	C1837342	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2J	3	CTD_human;GENOMICS_ENGLAND
Hgene	TTN	C0004238	Atrial Fibrillation	2	CTD_human
Hgene	TTN	C0235480	Paroxysmal atrial fibrillation	2	CTD_human
Hgene	TTN	C0751336	Distal Muscular Dystrophies	2	CTD_human;GENOMICS_ENGLAND
Hgene	TTN	C2585653	Persistent atrial fibrillation	2	CTD_human
Hgene	TTN	C3468561	familial atrial fibrillation	2	CTD_human
Hgene	TTN	C0003886	Arthrogryposis	1	GENOMICS_ENGLAND
Hgene	TTN	C0026848	Myopathy	1	CTD_human
Hgene	TTN	C0151786	Muscle Weakness	1	CTD_human
Hgene	TTN	C0221054	Welander Distal Myopathy	1	CTD_human
Hgene	TTN	C0270960	Congenital myopathy (disorder)	1	GENOMICS_ENGLAND
Hgene	TTN	C0340427	Familial dilated cardiomyopathy	1	CTD_human;ORPHANET
Hgene	TTN	C0410204	Myopathy, Centronuclear, Autosomal Recessive	1	ORPHANET
Hgene	TTN	C0686353	Muscular Dystrophies, Limb-Girdle	1	GENOMICS_ENGLAND
Hgene	TTN	C1450052	Tibial Muscular Dystrophy	1	CTD_human
Hgene	TTN	C1832931	ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 2	1	ORPHANET
Hgene	TTN	C1843687	ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)	1	ORPHANET
Hgene	TTN	C2678065	Myofibrillar Myopathy	1	GENOMICS_ENGLAND
Hgene	TTN	C3645536	Autosomal Recessive Centronuclear Myopathy	1	ORPHANET
Hgene	TTN	C4552004	Distal Myopathy 1	1	CTD_human
Tgene	TTN	C0007194	Hypertrophic Cardiomyopathy	9	CLINGEN
Tgene	TTN	C1858763	Cardiomyopathy, Dilated, 1g	7	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	TTN	C1861065	CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 9	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	TTN	C1863599	Hereditary Myopathy with Early Respiratory Failure	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	TTN	C2673677	Myopathy, Early-Onset, with Fatal Cardiomyopathy	5	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	TTN	C0007193	Cardiomyopathy, Dilated	4	CTD_human;GENOMICS_ENGLAND
Tgene	TTN	C1838244	TIBIAL MUSCULAR DYSTROPHY, TARDIVE	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	TTN	C1449563	Cardiomyopathy, Familial Idiopathic	3	CTD_human
Tgene	TTN	C1837342	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2J	3	CTD_human;GENOMICS_ENGLAND
Tgene	TTN	C0004238	Atrial Fibrillation	2	CTD_human
Tgene	TTN	C0235480	Paroxysmal atrial fibrillation	2	CTD_human
Tgene	TTN	C0751336	Distal Muscular Dystrophies	2	CTD_human;GENOMICS_ENGLAND
Tgene	TTN	C2585653	Persistent atrial fibrillation	2	CTD_human
Tgene	TTN	C3468561	familial atrial fibrillation	2	CTD_human
Tgene	TTN	C0003886	Arthrogryposis	1	GENOMICS_ENGLAND
Tgene	TTN	C0026848	Myopathy	1	CTD_human
Tgene	TTN	C0151786	Muscle Weakness	1	CTD_human
Tgene	TTN	C0221054	Welander Distal Myopathy	1	CTD_human
Tgene	TTN	C0270960	Congenital myopathy (disorder)	1	GENOMICS_ENGLAND
Tgene	TTN	C0340427	Familial dilated cardiomyopathy	1	CTD_human;ORPHANET
Tgene	TTN	C0410204	Myopathy, Centronuclear, Autosomal Recessive	1	ORPHANET
Tgene	TTN	C0686353	Muscular Dystrophies, Limb-Girdle	1	GENOMICS_ENGLAND
Tgene	TTN	C1450052	Tibial Muscular Dystrophy	1	CTD_human
Tgene	TTN	C1832931	ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 2	1	ORPHANET
Tgene	TTN	C1843687	ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)	1	ORPHANET
Tgene	TTN	C2678065	Myofibrillar Myopathy	1	GENOMICS_ENGLAND
Tgene	TTN	C3645536	Autosomal Recessive Centronuclear Myopathy	1	ORPHANET
Tgene	TTN	C4552004	Distal Myopathy 1	1	CTD_human