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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TUBGCP2-UBE4A (FusionGDB2 ID:94746)

Fusion Gene Summary for TUBGCP2-UBE4A

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBGCP2-UBE4A
Fusion gene ID: 94746
HgeneTgene
Gene symbol

TUBGCP2

UBE4A

Gene ID

10844

9354

Gene nametubulin gamma complex associated protein 2ubiquitination factor E4A
SynonymsALP4|GCP-2|GCP2|Grip103|PAMDDFS|SPBC97|SPC97|Spc97p|h103p|hGCP2|hSpc97E4|UBOX2|UFD2
Cytomap

10q26.3

11q23.3

Type of geneprotein-codingprotein-coding
Descriptiongamma-tubulin complex component 2gamma-ring complex protein 103 kDahGrip103spindle pole body protein Spc97 homologubiquitin conjugation factor E4 ARING-type E3 ubiquitin transferase E4 Aubiquitination factor E4A (UFD2 homolog, yeast)
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000252936, ENST00000417178, 
ENST00000368563, ENST00000368562, 
ENST00000543663, ENST00000470829, 
ENST00000252108, ENST00000431736, 
ENST00000545354, 
Fusion gene scores* DoF score5 X 4 X 5=1006 X 5 X 6=180
# samples 56
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUBGCP2 [Title/Abstract] AND UBE4A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTUBGCP2(135116296)-UBE4A(118261372), # samples:2
Anticipated loss of major functional domain due to fusion event.TUBGCP2-UBE4A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TUBGCP2-UBE4A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TUBGCP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across UBE4A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5522-01ATUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
ChimerDB4PRADTCGA-EJ-5522-01ATUBGCP2chr10

135116296

-UBE4Achr11

118261372

+


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Fusion Gene ORF analysis for TUBGCP2-UBE4A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000252936ENST00000252108TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
Frame-shiftENST00000252936ENST00000431736TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
Frame-shiftENST00000252936ENST00000545354TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
intron-3CDSENST00000417178ENST00000252108TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
intron-3CDSENST00000417178ENST00000431736TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
intron-3CDSENST00000417178ENST00000545354TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
In-frameENST00000368563ENST00000252108TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
In-frameENST00000368563ENST00000431736TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
In-frameENST00000368563ENST00000545354TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
intron-3CDSENST00000368562ENST00000252108TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
intron-3CDSENST00000368562ENST00000431736TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
intron-3CDSENST00000368562ENST00000545354TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
Frame-shiftENST00000543663ENST00000252108TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
Frame-shiftENST00000543663ENST00000431736TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
Frame-shiftENST00000543663ENST00000545354TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
5UTR-3CDSENST00000470829ENST00000252108TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
5UTR-3CDSENST00000470829ENST00000431736TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+
5UTR-3CDSENST00000470829ENST00000545354TUBGCP2chr10

135116296

-UBE4Achr11

118261372

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368563TUBGCP2chr10135116296-ENST00000252108UBE4Achr11118261372+3711507379939186
ENST00000368563TUBGCP2chr10135116296-ENST00000431736UBE4Achr11118261372+3707507379939186
ENST00000368563TUBGCP2chr10135116296-ENST00000545354UBE4Achr11118261372+1007507379939186

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368563ENST00000252108TUBGCP2chr10135116296-UBE4Achr11118261372+0.0026962280.9973037
ENST00000368563ENST00000431736TUBGCP2chr10135116296-UBE4Achr11118261372+0.0046483920.99535155
ENST00000368563ENST00000545354TUBGCP2chr10135116296-UBE4Achr11118261372+0.021706270.9782938

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Fusion Genomic Features for TUBGCP2-UBE4A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TUBGCP2chr10135116295-UBE4Achr11118261371+0.0001166160.9998834
TUBGCP2chr10135116295-UBE4Achr11118261371+0.0001166160.9998834

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TUBGCP2-UBE4A


check button Go to

FGviewer for the breakpoints of chr10:135116296-chr11:118261372

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUBE4Achr10:135116296chr11:118261372ENST000002521081620987_1061922.66666666666661067.0DomainNote=U-box
TgeneUBE4Achr10:135116296chr11:118261372ENST000004317361620987_1061929.66666666666661074.0DomainNote=U-box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUBGCP2chr10:135116296chr11:118261372ENST00000252936-117109_11250.0903.0Compositional biasNote=Poly-Ala
HgeneTUBGCP2chr10:135116296chr11:118261372ENST00000368563-218109_11250.0903.0Compositional biasNote=Poly-Ala
HgeneTUBGCP2chr10:135116296chr11:118261372ENST00000417178-117109_1120773.0Compositional biasNote=Poly-Ala
HgeneTUBGCP2chr10:135116296chr11:118261372ENST00000543663-118109_11250.0931.0Compositional biasNote=Poly-Ala


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Fusion Gene Sequence for TUBGCP2-UBE4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000368563_ENST00000252108_TCGA-EJ-5522-01A_TUBGCP2_chr10_135116296_-_UBE4A_chr11_118261372_length(transcript)=3711nt_BP=507nt
CCACTGGATCCTACAACTACTTTTTCCCTCTTTTGCTCACGCACCTCGAAGAACTGGTGCTCCCGCGGGAAGCGCACGGGGCGCGCAACG
AAGCGAAAGGGCGCGGCCCCAGCCGCGGGATCCCGCTCTACAGGCAGCGGCTCCGCCGCCCCGGGCCCCGCAGCGAGGCGGGCGCACAGC
GCGGGGGGCAACTGCATCACCCCGGGCGCGGGCGGGCGCAGCCTGTCGGCCACCGTCCGCGAGCCGAGCCGGACGTGACGTCACGCTCAC
TTCCGCCGCCGTCGGGGGCTGCGCGGGGGCTGTGGCTCCGGGACTGCGGAGAACATATTGTGATGTTCGTGCCTCAGAGCTAAAACTATG
AGTGAATTTCGGATTCACCATGACGTCAATGAACTGCTTAGCCTGCTGCGTGTCCACGGAGGAGATGGGGCTGAGGTCTACATTGACCTG
CTTCAAAAGAACAGGACCCCGTACGTCACTACCACTGTCTCTGCTCACAGTGCCAAGGGATGAGGAGAATTTCTGTGCCACTGTGCCCAA
GGATGGACGTTCCTATTCCCCAACTCTCTTTGCACAGACAGTTCGAGTCTTGAAGAAAATAAATAAGCCTGGGAATATGATTATGGCTTT
CAGCAACTTGGCAGAGAGAATCAAGTCTCTTGCAGACCTCCAACAACAGGAAGAGGAAACCTATGCAGATGCCTGTGATGAGTTCCTGGA
TCCCATTATGAGCACACTGATGTGTGACCCTGTGGTGCTGCCATCTTCCAGAGTCACTGTGGATAGATCCACCATTGCAAGACATTTGCT
CAGTGACCAAACAGATCCCTTTAACCGTAGTCCCCTCACCATGGACCAGATCCGGCCAAACACAGAACTAAAAGAAAAAATCCAACGGTG
GCTTGCAGAGAGGAAACAACAAAAGGAGCAACTTGAATAGATACTGTGAACTAACCAAACCAAAACCAACCCCAGAGTGCAGATAAACAA
TTGTTTGTGGTTTCTCTCTTTCTGGTTCTGTTCCTTTTCTTTCTTCTTTTCTTTTTCTTTTTTTTTTTTTTTTTTACTAAATTAGAGAAC
TGCTCTTGCTGAAATTATGATAGTTAAGATTCCTAAGAACTTGACAATGCTCCCCTGGCTTGCAGGAAATTATACTTATTATAGCATCAC
CAAGTTTAGAAATCATCACTAATTTTCACCCTCTGTTGTCTCTTCATATTCTTCTTCCTTTTCCTAAATGAAATTATATTATTTCAACTA
CTAAAACTTCCCGCCACCCTGCTATTTCTCTTCCAATTACTGTTCAAACATTTTTGGTGAGTGCTGCTTTTATAAATATGTGATGTCACA
TATTTCAGTGACAGCTGATGTTATCAGAAAAATCCTGTTATCCTGTGTATTTACTAGTCCTCATGATCTAGACTTAACCCCTTTTCTGTG
TTACAGAGTAACTTCACATAAAAGCAGATACCTTTAAGTTTGTGTAGACTTCTGAATAAGATGATAGACGAGAATTTTTTTTAAAAAAGG
AATTTAAAGGAATCTTGTGCAACTTCTGTTGATAGCTCTTAATTTTGTTATACAGTCTTTTTAATGAGGATTGGTAGGGCAATCCTACCA
ATTGATGGGGGTGAGGAGACTGTTGGGCCCTTATTCTCTTATGAAAATCTGTTTCTACAAGGACTAGGCCTAAGTAGATTTAGGCAACGG
GTATCATATCCATGAAAAATGTCATTTTAAGACACTAATATCAACAGTATATCTCAGTGTGTGAGATATATAAATACACATACACCCCAT
GTGCTTTTTTGTTGGTTTAGTGTAAACTGAGTACCACTTTATATTTTCTCTTCCATAGTGAGATGTATGCAGTATGTGGCCATGTTTACT
AACATACTCATTCTTCACAAAATTCTGAGATTATAAAATGTATATAGTTAATATTTGTTTGAGCTTGTGACCTGACTTCTAAGAGCTACT
TCTAACACAGCCTTAGGTCTTCAATTAACAAAGTAGGAAGTTGAGCACAACCTTGTCCACAGCCATTTTAAATATCCACTTAGCCCTGTG
TAGTTGGTAGGTGGACACCACTTTCATAAGTGAACTTGAGCTCACTACTCAATTGTGCAGCTTAATATGCTGACTAGGGACATTCCCCTA
TGGATTATCTTTATATCACTGTCTTTCTAAGCCCAGAGATGTCATAAGTGACAAGAAAAGTGATAGGATCAAGAAATGGGTGTCACTGCT
TCATTTGGAACATGTTATTAACTATGGTCTCTTTCAAATAAATAGTAGTTTTATATTTCAACACAAGTTGCTATAAGCAGTCCTTGATGG
GTTTTTGATTGCATCAGCTGGAAAGCCTCAAATCTAAGAGGGCTTCCCATCCTAGATATAAAATAGGTGTTGCCTATTGCTGTGCTTATA
AAATGAAAAAGGAAATTGAGGACACTTTTGCAAATGCCAGAATGTAAGATTCATTCAGTGTGCTCCCTGGGCCTTTATGGCATGGGTTGA
CAGGATTTGTTTATTTTCTAAAATTAGCTTCATTCAATATTTATCATCCTCCTTTCCCTCTCTGAGAATGAACTATGTATAAAATAAGCT
TCTGCCTATTTGCATTTATCTTCCAAACCCAATCTAGTAGGATGTTCTCATTTTAAAAACGAGGGGAAAAGACCAGAGTTTTTCAGGAGA
AAACTGGAGGAAAATGGGCACAAAAACTCAGAAGGCAGCTATTCCCAGCAGCTTCCTAGTTAACAACCCCCATGCTGCCTCCAGTCTTTG
TCTGTATTCTTCTGTATTTAACCTTCAGATTGTAAGCCTTTTCTGGCAAGCTTTTCTTCTTTTTTTAAACTCTTTTCCTGAAACTTTTTA
TGAATGGCTATGGCACCATTAATGCTGCTGAATATCTTTAAACTCTGCACAAGCAAGTGTGTAGCTTAAGGCCACTACTGGTAAGGAAAC
CAAGTGTCCTCTGTGCCTTTTTTCTTTCTGTGAAGTAATTTAAGAATATCCAAAAAAATTAGACTTTAAAAAGTTATCTTGGTACAACAC
CGTGTGTATATACACTTGGAAGCTTAAAAAGGTGTTTTGTCTGGAACTTAGAAGCAGCTCTAAATCTAGTAGAGCAGACTTTCTAACATA
CCTAGTTTTGTGTATTGGCTTTGCTGGAGTATGATAGCAAAATGAAGACTCTTTTACTCAGCTCTGGTATTGCTCATAACTTACCAAGAG
GCTAATACTAAACTTGGAAAATTGTTTAAGTATGTTTTATCAAGCAGTCTGGGTTTTGTTTTTTAATATACTTTTTAATGGATATGTGAA
AACTGAAGGAAATGTTAAAGGTTTTTTAATGGTGCAAGTGAAGGTGCCAGTTGCTATTTGATATCACACTCTACAAAAGCTTCATTACTT
TATTTGATGGTGGTTGCTAAGCAGCCATTGCACAGAGCATAAGTCTACTGGGTGCCTTTACATGCCAGAGGCTGATGCTGCACTGTTGAT
GTCATGTGAGGAAATAATGCACATGCTCTAACTGCTCAACAGGAAATGAACCTAGAAACAGAAAATGAAAAGGTTGATTGAAATAAAACT
TGATCAACGCGACTGTATTTTGAAACATTCCAGGAAGGTTACTTCTTGTCAAACTTGCCTGGCAGTGTTTGTTCAAAACTTGTATTTAAT

>In-frame_ENST00000368563_ENST00000252108_TCGA-EJ-5522-01A_TUBGCP2_chr10_135116296_-_UBE4A_chr11_118261372_length(amino acids)=186AA_start in transcript=379_stop in transcript=939
MTSMNCLACCVSTEEMGLRSTLTCFKRTGPRTSLPLSLLTVPRDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNMIMAFSNLAER
IKSLADLQQQEEETYADACDEFLDPIMSTLMCDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQ

--------------------------------------------------------------
>In-frame_ENST00000368563_ENST00000431736_TCGA-EJ-5522-01A_TUBGCP2_chr10_135116296_-_UBE4A_chr11_118261372_length(transcript)=3707nt_BP=507nt
CCACTGGATCCTACAACTACTTTTTCCCTCTTTTGCTCACGCACCTCGAAGAACTGGTGCTCCCGCGGGAAGCGCACGGGGCGCGCAACG
AAGCGAAAGGGCGCGGCCCCAGCCGCGGGATCCCGCTCTACAGGCAGCGGCTCCGCCGCCCCGGGCCCCGCAGCGAGGCGGGCGCACAGC
GCGGGGGGCAACTGCATCACCCCGGGCGCGGGCGGGCGCAGCCTGTCGGCCACCGTCCGCGAGCCGAGCCGGACGTGACGTCACGCTCAC
TTCCGCCGCCGTCGGGGGCTGCGCGGGGGCTGTGGCTCCGGGACTGCGGAGAACATATTGTGATGTTCGTGCCTCAGAGCTAAAACTATG
AGTGAATTTCGGATTCACCATGACGTCAATGAACTGCTTAGCCTGCTGCGTGTCCACGGAGGAGATGGGGCTGAGGTCTACATTGACCTG
CTTCAAAAGAACAGGACCCCGTACGTCACTACCACTGTCTCTGCTCACAGTGCCAAGGGATGAGGAGAATTTCTGTGCCACTGTGCCCAA
GGATGGACGTTCCTATTCCCCAACTCTCTTTGCACAGACAGTTCGAGTCTTGAAGAAAATAAATAAGCCTGGGAATATGATTATGGCTTT
CAGCAACTTGGCAGAGAGAATCAAGTCTCTTGCAGACCTCCAACAACAGGAAGAGGAAACCTATGCAGATGCCTGTGATGAGTTCCTGGA
TCCCATTATGAGCACACTGATGTGTGACCCTGTGGTGCTGCCATCTTCCAGAGTCACTGTGGATAGATCCACCATTGCAAGACATTTGCT
CAGTGACCAAACAGATCCCTTTAACCGTAGTCCCCTCACCATGGACCAGATCCGGCCAAACACAGAACTAAAAGAAAAAATCCAACGGTG
GCTTGCAGAGAGGAAACAACAAAAGGAGCAACTTGAATAGATACTGTGAACTAACCAAACCAAAACCAACCCCAGAGTGCAGATAAACAA
TTGTTTGTGGTTTCTCTCTTTCTGGTTCTGTTCCTTTTCTTTCTTCTTTTCTTTTTCTTTTTTTTTTTTTTTTTTACTAAATTAGAGAAC
TGCTCTTGCTGAAATTATGATAGTTAAGATTCCTAAGAACTTGACAATGCTCCCCTGGCTTGCAGGAAATTATACTTATTATAGCATCAC
CAAGTTTAGAAATCATCACTAATTTTCACCCTCTGTTGTCTCTTCATATTCTTCTTCCTTTTCCTAAATGAAATTATATTATTTCAACTA
CTAAAACTTCCCGCCACCCTGCTATTTCTCTTCCAATTACTGTTCAAACATTTTTGGTGAGTGCTGCTTTTATAAATATGTGATGTCACA
TATTTCAGTGACAGCTGATGTTATCAGAAAAATCCTGTTATCCTGTGTATTTACTAGTCCTCATGATCTAGACTTAACCCCTTTTCTGTG
TTACAGAGTAACTTCACATAAAAGCAGATACCTTTAAGTTTGTGTAGACTTCTGAATAAGATGATAGACGAGAATTTTTTTTAAAAAAGG
AATTTAAAGGAATCTTGTGCAACTTCTGTTGATAGCTCTTAATTTTGTTATACAGTCTTTTTAATGAGGATTGGTAGGGCAATCCTACCA
ATTGATGGGGGTGAGGAGACTGTTGGGCCCTTATTCTCTTATGAAAATCTGTTTCTACAAGGACTAGGCCTAAGTAGATTTAGGCAACGG
GTATCATATCCATGAAAAATGTCATTTTAAGACACTAATATCAACAGTATATCTCAGTGTGTGAGATATATAAATACACATACACCCCAT
GTGCTTTTTTGTTGGTTTAGTGTAAACTGAGTACCACTTTATATTTTCTCTTCCATAGTGAGATGTATGCAGTATGTGGCCATGTTTACT
AACATACTCATTCTTCACAAAATTCTGAGATTATAAAATGTATATAGTTAATATTTGTTTGAGCTTGTGACCTGACTTCTAAGAGCTACT
TCTAACACAGCCTTAGGTCTTCAATTAACAAAGTAGGAAGTTGAGCACAACCTTGTCCACAGCCATTTTAAATATCCACTTAGCCCTGTG
TAGTTGGTAGGTGGACACCACTTTCATAAGTGAACTTGAGCTCACTACTCAATTGTGCAGCTTAATATGCTGACTAGGGACATTCCCCTA
TGGATTATCTTTATATCACTGTCTTTCTAAGCCCAGAGATGTCATAAGTGACAAGAAAAGTGATAGGATCAAGAAATGGGTGTCACTGCT
TCATTTGGAACATGTTATTAACTATGGTCTCTTTCAAATAAATAGTAGTTTTATATTTCAACACAAGTTGCTATAAGCAGTCCTTGATGG
GTTTTTGATTGCATCAGCTGGAAAGCCTCAAATCTAAGAGGGCTTCCCATCCTAGATATAAAATAGGTGTTGCCTATTGCTGTGCTTATA
AAATGAAAAAGGAAATTGAGGACACTTTTGCAAATGCCAGAATGTAAGATTCATTCAGTGTGCTCCCTGGGCCTTTATGGCATGGGTTGA
CAGGATTTGTTTATTTTCTAAAATTAGCTTCATTCAATATTTATCATCCTCCTTTCCCTCTCTGAGAATGAACTATGTATAAAATAAGCT
TCTGCCTATTTGCATTTATCTTCCAAACCCAATCTAGTAGGATGTTCTCATTTTAAAAACGAGGGGAAAAGACCAGAGTTTTTCAGGAGA
AAACTGGAGGAAAATGGGCACAAAAACTCAGAAGGCAGCTATTCCCAGCAGCTTCCTAGTTAACAACCCCCATGCTGCCTCCAGTCTTTG
TCTGTATTCTTCTGTATTTAACCTTCAGATTGTAAGCCTTTTCTGGCAAGCTTTTCTTCTTTTTTTAAACTCTTTTCCTGAAACTTTTTA
TGAATGGCTATGGCACCATTAATGCTGCTGAATATCTTTAAACTCTGCACAAGCAAGTGTGTAGCTTAAGGCCACTACTGGTAAGGAAAC
CAAGTGTCCTCTGTGCCTTTTTTCTTTCTGTGAAGTAATTTAAGAATATCCAAAAAAATTAGACTTTAAAAAGTTATCTTGGTACAACAC
CGTGTGTATATACACTTGGAAGCTTAAAAAGGTGTTTTGTCTGGAACTTAGAAGCAGCTCTAAATCTAGTAGAGCAGACTTTCTAACATA
CCTAGTTTTGTGTATTGGCTTTGCTGGAGTATGATAGCAAAATGAAGACTCTTTTACTCAGCTCTGGTATTGCTCATAACTTACCAAGAG
GCTAATACTAAACTTGGAAAATTGTTTAAGTATGTTTTATCAAGCAGTCTGGGTTTTGTTTTTTAATATACTTTTTAATGGATATGTGAA
AACTGAAGGAAATGTTAAAGGTTTTTTAATGGTGCAAGTGAAGGTGCCAGTTGCTATTTGATATCACACTCTACAAAAGCTTCATTACTT
TATTTGATGGTGGTTGCTAAGCAGCCATTGCACAGAGCATAAGTCTACTGGGTGCCTTTACATGCCAGAGGCTGATGCTGCACTGTTGAT
GTCATGTGAGGAAATAATGCACATGCTCTAACTGCTCAACAGGAAATGAACCTAGAAACAGAAAATGAAAAGGTTGATTGAAATAAAACT
TGATCAACGCGACTGTATTTTGAAACATTCCAGGAAGGTTACTTCTTGTCAAACTTGCCTGGCAGTGTTTGTTCAAAACTTGTATTTAAT

>In-frame_ENST00000368563_ENST00000431736_TCGA-EJ-5522-01A_TUBGCP2_chr10_135116296_-_UBE4A_chr11_118261372_length(amino acids)=186AA_start in transcript=379_stop in transcript=939
MTSMNCLACCVSTEEMGLRSTLTCFKRTGPRTSLPLSLLTVPRDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNMIMAFSNLAER
IKSLADLQQQEEETYADACDEFLDPIMSTLMCDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQ

--------------------------------------------------------------
>In-frame_ENST00000368563_ENST00000545354_TCGA-EJ-5522-01A_TUBGCP2_chr10_135116296_-_UBE4A_chr11_118261372_length(transcript)=1007nt_BP=507nt
CCACTGGATCCTACAACTACTTTTTCCCTCTTTTGCTCACGCACCTCGAAGAACTGGTGCTCCCGCGGGAAGCGCACGGGGCGCGCAACG
AAGCGAAAGGGCGCGGCCCCAGCCGCGGGATCCCGCTCTACAGGCAGCGGCTCCGCCGCCCCGGGCCCCGCAGCGAGGCGGGCGCACAGC
GCGGGGGGCAACTGCATCACCCCGGGCGCGGGCGGGCGCAGCCTGTCGGCCACCGTCCGCGAGCCGAGCCGGACGTGACGTCACGCTCAC
TTCCGCCGCCGTCGGGGGCTGCGCGGGGGCTGTGGCTCCGGGACTGCGGAGAACATATTGTGATGTTCGTGCCTCAGAGCTAAAACTATG
AGTGAATTTCGGATTCACCATGACGTCAATGAACTGCTTAGCCTGCTGCGTGTCCACGGAGGAGATGGGGCTGAGGTCTACATTGACCTG
CTTCAAAAGAACAGGACCCCGTACGTCACTACCACTGTCTCTGCTCACAGTGCCAAGGGATGAGGAGAATTTCTGTGCCACTGTGCCCAA
GGATGGACGTTCCTATTCCCCAACTCTCTTTGCACAGACAGTTCGAGTCTTGAAGAAAATAAATAAGCCTGGGAATATGATTATGGCTTT
CAGCAACTTGGCAGAGAGAATCAAGTCTCTTGCAGACCTCCAACAACAGGAAGAGGAAACCTATGCAGATGCCTGTGATGAGTTCCTGGA
TCCCATTATGAGCACACTGATGTGTGACCCTGTGGTGCTGCCATCTTCCAGAGTCACTGTGGATAGATCCACCATTGCAAGACATTTGCT
CAGTGACCAAACAGATCCCTTTAACCGTAGTCCCCTCACCATGGACCAGATCCGGCCAAACACAGAACTAAAAGAAAAAATCCAACGGTG
GCTTGCAGAGAGGAAACAACAAAAGGAGCAACTTGAATAGATACTGTGAACTAACCAAACCAAAACCAACCCCAGAGTGCAGATAAACAA

>In-frame_ENST00000368563_ENST00000545354_TCGA-EJ-5522-01A_TUBGCP2_chr10_135116296_-_UBE4A_chr11_118261372_length(amino acids)=186AA_start in transcript=379_stop in transcript=939
MTSMNCLACCVSTEEMGLRSTLTCFKRTGPRTSLPLSLLTVPRDEENFCATVPKDGRSYSPTLFAQTVRVLKKINKPGNMIMAFSNLAER
IKSLADLQQQEEETYADACDEFLDPIMSTLMCDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQ

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Fusion Gene PPI Analysis for TUBGCP2-UBE4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TUBGCP2-UBE4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TUBGCP2-UBE4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource