FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TYK2-CIB3 (FusionGDB2 ID:94990)

Fusion Gene Summary for TYK2-CIB3

check button Fusion gene summary
Fusion gene informationFusion gene name: TYK2-CIB3
Fusion gene ID: 94990
HgeneTgene
Gene symbol

TYK2

CIB3

Gene ID

7297

117286

Gene nametyrosine kinase 2calcium and integrin binding family member 3
SynonymsIMD35|JTK1KIP3
Cytomap

19p13.2

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionnon-receptor tyrosine-protein kinase TYK2calcium and integrin-binding family member 3DNA-dependent protein kinase catalytic subunit-interacting protein 3
Modification date2020032920200313
UniProtAcc.

Q96Q77

Ensembl transtripts involved in fusion geneENST00000264818, ENST00000524462, 
ENST00000525621, ENST00000529370, 
ENST00000529422, 		ENST00000269878, 
ENST00000379859, ENST00000541493, 
Fusion gene scores* DoF score13 X 11 X 8=11446 X 5 X 5=150
# samples 159
** MAII scorelog2(15/1144*10)=-2.93105264628251
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/150*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TYK2 [Title/Abstract] AND CIB3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTYK2(10488890)-CIB3(16275724), # samples:2
Anticipated loss of major functional domain due to fusion event.TYK2-CIB3 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
TYK2-CIB3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TYK2-CIB3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TYK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CIB3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3LY-01BTYK2chr19

10488890

-CIB3chr19

16275724

-
ChimerDB4SARCTCGA-DX-A3LY-01BTYK2chr19

10488890

-CIB3chr19

16275724

-


Top

Fusion Gene ORF analysis for TYK2-CIB3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000264818ENST00000269878TYK2chr19

10488890

-CIB3chr19

16275724

-
Frame-shiftENST00000264818ENST00000379859TYK2chr19

10488890

-CIB3chr19

16275724

-
5CDS-5UTRENST00000264818ENST00000541493TYK2chr19

10488890

-CIB3chr19

16275724

-
intron-3CDSENST00000524462ENST00000269878TYK2chr19

10488890

-CIB3chr19

16275724

-
intron-3CDSENST00000524462ENST00000379859TYK2chr19

10488890

-CIB3chr19

16275724

-
intron-5UTRENST00000524462ENST00000541493TYK2chr19

10488890

-CIB3chr19

16275724

-
In-frameENST00000525621ENST00000269878TYK2chr19

10488890

-CIB3chr19

16275724

-
In-frameENST00000525621ENST00000379859TYK2chr19

10488890

-CIB3chr19

16275724

-
5CDS-5UTRENST00000525621ENST00000541493TYK2chr19

10488890

-CIB3chr19

16275724

-
In-frameENST00000529370ENST00000269878TYK2chr19

10488890

-CIB3chr19

16275724

-
In-frameENST00000529370ENST00000379859TYK2chr19

10488890

-CIB3chr19

16275724

-
5CDS-5UTRENST00000529370ENST00000541493TYK2chr19

10488890

-CIB3chr19

16275724

-
intron-3CDSENST00000529422ENST00000269878TYK2chr19

10488890

-CIB3chr19

16275724

-
intron-3CDSENST00000529422ENST00000379859TYK2chr19

10488890

-CIB3chr19

16275724

-
intron-5UTRENST00000529422ENST00000541493TYK2chr19

10488890

-CIB3chr19

16275724

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000525621TYK2chr1910488890-ENST00000269878CIB3chr1916275724-990675482892136
ENST00000525621TYK2chr1910488890-ENST00000379859CIB3chr1916275724-943675482892136
ENST00000529370TYK2chr1910488890-ENST00000269878CIB3chr1916275724-839524331741136
ENST00000529370TYK2chr1910488890-ENST00000379859CIB3chr1916275724-792524331741136

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000525621ENST00000269878TYK2chr1910488890-CIB3chr1916275724-0.0148777660.9851222
ENST00000525621ENST00000379859TYK2chr1910488890-CIB3chr1916275724-0.0128038990.9871961
ENST00000529370ENST00000269878TYK2chr1910488890-CIB3chr1916275724-0.0100228060.9899771
ENST00000529370ENST00000379859TYK2chr1910488890-CIB3chr1916275724-0.009546280.9904537

Top

Fusion Genomic Features for TYK2-CIB3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TYK2-CIB3


check button Go to

FGviewer for the breakpoints of chr19:10488890-chr19:16275724

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CIB3

Q96Q77

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCIB3chr19:10488890chr19:16275724ENST0000026987836116_127115.33333333333333188.0Calcium binding1
TgeneCIB3chr19:10488890chr19:16275724ENST0000026987836157_168115.33333333333333188.0Calcium binding2
TgeneCIB3chr19:10488890chr19:16275724ENST0000026987836144_179115.33333333333333188.0DomainEF-hand 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTYK2chr19:10488890chr19:16275724ENST00000264818-12326_43164.333333333333331188.0DomainFERM
HgeneTYK2chr19:10488890chr19:16275724ENST00000264818-123450_52964.333333333333331188.0DomainNote=SH2%3B atypical
HgeneTYK2chr19:10488890chr19:16275724ENST00000264818-123589_87564.333333333333331188.0DomainProtein kinase 1
HgeneTYK2chr19:10488890chr19:16275724ENST00000264818-123897_117664.333333333333331188.0DomainProtein kinase 2
HgeneTYK2chr19:10488890chr19:16275724ENST00000525621-32526_43164.333333333333331188.0DomainFERM
HgeneTYK2chr19:10488890chr19:16275724ENST00000525621-325450_52964.333333333333331188.0DomainNote=SH2%3B atypical
HgeneTYK2chr19:10488890chr19:16275724ENST00000525621-325589_87564.333333333333331188.0DomainProtein kinase 1
HgeneTYK2chr19:10488890chr19:16275724ENST00000525621-325897_117664.333333333333331188.0DomainProtein kinase 2
HgeneTYK2chr19:10488890chr19:16275724ENST00000264818-123903_91164.333333333333331188.0Nucleotide bindingATP
HgeneTYK2chr19:10488890chr19:16275724ENST00000525621-325903_91164.333333333333331188.0Nucleotide bindingATP
TgeneCIB3chr19:10488890chr19:16275724ENST0000026987836103_138115.33333333333333188.0DomainEF-hand 2
TgeneCIB3chr19:10488890chr19:16275724ENST000002698783666_101115.33333333333333188.0DomainEF-hand 1


Top

Fusion Gene Sequence for TYK2-CIB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000525621_ENST00000269878_TCGA-DX-A3LY-01B_TYK2_chr19_10488890_-_CIB3_chr19_16275724_length(transcript)=990nt_BP=675nt
AAAAAAAAAAAAATCCAATGGTGACGAGCAGGGAGAACAGAGCAGCTGCCAATGGGCGTGTGCGTTTCAGGCGGCCAATGGGAGGAGGCG
TCTCGGCGGGGGACAAGCAGTAGCTACCCGCGGGAGCGGGGAGGGGTCCGGGTTCGAGCTTGTGTTCCCCCGGAAGGGTGAGTCTGGACG
CGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCTTGACAGGCTGCACTTGGATGGGAGCACCT
GGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATATTGAAACATTACAACCATCTTTTGATGGC
AACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGCTTGCTTGAGTTGACACAGGGAGCTCCAGG
ACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAGGGGCAGTAAGCCCGTTGGGGATGGAGCCC
AGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGGGGAGCCCTGGGTCACTTTCAGTGAGTCAT
CGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGATTTTAACAACGACGACTACATTTGTGCGTGGGACCTGGAGCAGA
CGGTGACCAAACTGACGCGGGGGGGGCTGAGTGCCGAGGAGGTGAGCCTGGTATGTGAGAAGGTGCTGGATGAGGCTGATGGAGACCATG
ATGGGCGGCTGTCCCTGGAAGATTTCCAGAACATGATCCTCCGGGCACCAGACTTCCTCAGCACCTTCCACATCCGAATCTGATGGCACC
ACAGAGGAGCCGAGCTATAGGAGGGCGGGGTGACCCCTCACCCGCTGTGGACTCTGGTTTCTGAGAATAAACACAAGTCACTGAGTCACA

>In-frame_ENST00000525621_ENST00000269878_TCGA-DX-A3LY-01B_TYK2_chr19_10488890_-_CIB3_chr19_16275724_length(amino acids)=136AA_start in transcript=482_stop in transcript=892
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVDFNNDDYICAWDLEQTVTKLTRGGLS

--------------------------------------------------------------
>In-frame_ENST00000525621_ENST00000379859_TCGA-DX-A3LY-01B_TYK2_chr19_10488890_-_CIB3_chr19_16275724_length(transcript)=943nt_BP=675nt
AAAAAAAAAAAAATCCAATGGTGACGAGCAGGGAGAACAGAGCAGCTGCCAATGGGCGTGTGCGTTTCAGGCGGCCAATGGGAGGAGGCG
TCTCGGCGGGGGACAAGCAGTAGCTACCCGCGGGAGCGGGGAGGGGTCCGGGTTCGAGCTTGTGTTCCCCCGGAAGGGTGAGTCTGGACG
CGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCTTGACAGGCTGCACTTGGATGGGAGCACCT
GGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATATTGAAACATTACAACCATCTTTTGATGGC
AACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGCTTGCTTGAGTTGACACAGGGAGCTCCAGG
ACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAGGGGCAGTAAGCCCGTTGGGGATGGAGCCC
AGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGGGGAGCCCTGGGTCACTTTCAGTGAGTCAT
CGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGATTTTAACAACGACGACTACATTTGTGCGTGGGACCTGGAGCAGA
CGGTGACCAAACTGACGCGGGGGGGGCTGAGTGCCGAGGAGGTGAGCCTGGTATGTGAGAAGGTGCTGGATGAGGCTGATGGAGACCATG
ATGGGCGGCTGTCCCTGGAAGATTTCCAGAACATGATCCTCCGGGCACCAGACTTCCTCAGCACCTTCCACATCCGAATCTGATGGCACC

>In-frame_ENST00000525621_ENST00000379859_TCGA-DX-A3LY-01B_TYK2_chr19_10488890_-_CIB3_chr19_16275724_length(amino acids)=136AA_start in transcript=482_stop in transcript=892
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVDFNNDDYICAWDLEQTVTKLTRGGLS

--------------------------------------------------------------
>In-frame_ENST00000529370_ENST00000269878_TCGA-DX-A3LY-01B_TYK2_chr19_10488890_-_CIB3_chr19_16275724_length(transcript)=839nt_BP=524nt
GTGTTCCCCCGGAAGGGTGAGTCTGGACGCGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCT
TGACAGGCTGCACTTGGATGGGAGCACCTGGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATA
TTGAAACATTACAACCATCTTTTGATGGCAACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGC
TTGCTTGAGTTGACACAGGGAGCTCCAGGACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAG
GGGCAGTAAGCCCGTTGGGGATGGAGCCCAGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGG
GGAGCCCTGGGTCACTTTCAGTGAGTCATCGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGATTTTAACAACGACGA
CTACATTTGTGCGTGGGACCTGGAGCAGACGGTGACCAAACTGACGCGGGGGGGGCTGAGTGCCGAGGAGGTGAGCCTGGTATGTGAGAA
GGTGCTGGATGAGGCTGATGGAGACCATGATGGGCGGCTGTCCCTGGAAGATTTCCAGAACATGATCCTCCGGGCACCAGACTTCCTCAG
CACCTTCCACATCCGAATCTGATGGCACCACAGAGGAGCCGAGCTATAGGAGGGCGGGGTGACCCCTCACCCGCTGTGGACTCTGGTTTC

>In-frame_ENST00000529370_ENST00000269878_TCGA-DX-A3LY-01B_TYK2_chr19_10488890_-_CIB3_chr19_16275724_length(amino acids)=136AA_start in transcript=331_stop in transcript=741
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVDFNNDDYICAWDLEQTVTKLTRGGLS

--------------------------------------------------------------
>In-frame_ENST00000529370_ENST00000379859_TCGA-DX-A3LY-01B_TYK2_chr19_10488890_-_CIB3_chr19_16275724_length(transcript)=792nt_BP=524nt
GTGTTCCCCCGGAAGGGTGAGTCTGGACGCGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCT
TGACAGGCTGCACTTGGATGGGAGCACCTGGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATA
TTGAAACATTACAACCATCTTTTGATGGCAACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGC
TTGCTTGAGTTGACACAGGGAGCTCCAGGACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAG
GGGCAGTAAGCCCGTTGGGGATGGAGCCCAGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGG
GGAGCCCTGGGTCACTTTCAGTGAGTCATCGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGATTTTAACAACGACGA
CTACATTTGTGCGTGGGACCTGGAGCAGACGGTGACCAAACTGACGCGGGGGGGGCTGAGTGCCGAGGAGGTGAGCCTGGTATGTGAGAA
GGTGCTGGATGAGGCTGATGGAGACCATGATGGGCGGCTGTCCCTGGAAGATTTCCAGAACATGATCCTCCGGGCACCAGACTTCCTCAG

>In-frame_ENST00000529370_ENST00000379859_TCGA-DX-A3LY-01B_TYK2_chr19_10488890_-_CIB3_chr19_16275724_length(amino acids)=136AA_start in transcript=331_stop in transcript=741
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVDFNNDDYICAWDLEQTVTKLTRGGLS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TYK2-CIB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TYK2-CIB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TYK2-CIB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTYK2C1969086Tyrosine Kinase 2 Deficiency3CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneTYK2C0003873Rheumatoid Arthritis2CTD_human
HgeneTYK2C0008312Primary biliary cirrhosis1CTD_human
HgeneTYK2C0009171Cocaine Abuse1CTD_human
HgeneTYK2C0010346Crohn Disease1CTD_human;GENOMICS_ENGLAND
HgeneTYK2C0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
HgeneTYK2C0023892Biliary cirrhosis1CTD_human
HgeneTYK2C0026769Multiple Sclerosis1CTD_human
HgeneTYK2C0030246Pustulosis of Palms and Soles1CTD_human
HgeneTYK2C0033860Psoriasis1CTD_human
HgeneTYK2C0041696Unipolar Depression1PSYGENET
HgeneTYK2C0156147Crohn's disease of large bowel1CTD_human
HgeneTYK2C0205734Diabetes, Autoimmune1CTD_human
HgeneTYK2C0206182Lymphomatoid Papulosis1ORPHANET
HgeneTYK2C0236736Cocaine-Related Disorders1CTD_human
HgeneTYK2C0238065Secondary Biliary Cholangitis1CTD_human
HgeneTYK2C0267380Crohn's disease of the ileum1CTD_human
HgeneTYK2C0342302Brittle diabetes1CTD_human
HgeneTYK2C0344315Depressed mood1PSYGENET
HgeneTYK2C0600427Cocaine Dependence1CTD_human
HgeneTYK2C0678202Regional enteritis1CTD_human
HgeneTYK2C0751324Multiple Sclerosis, Acute Fulminating1CTD_human
HgeneTYK2C0949272IIeocolitis1CTD_human
HgeneTYK2C1269683Major Depressive Disorder1PSYGENET
HgeneTYK2C1301362Primary Cutaneous Anaplastic Large Cell Lymphoma1ORPHANET
HgeneTYK2C1456784Paranoia1CTD_human
HgeneTYK2C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
HgeneTYK2C3837958Diabetes Mellitus, Ketosis-Prone1CTD_human
HgeneTYK2C4551595Biliary Cirrhosis, Primary, 11CTD_human
HgeneTYK2C4554117Diabetes Mellitus, Sudden-Onset1CTD_human