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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:U2AF2-POLR2E (FusionGDB2 ID:95095) |
Fusion Gene Summary for U2AF2-POLR2E |
Fusion gene summary |
Fusion gene information | Fusion gene name: U2AF2-POLR2E | Fusion gene ID: 95095 | Hgene | Tgene | Gene symbol | U2AF2 | POLR2E | Gene ID | 11338 | 5434 |
Gene name | U2 small nuclear RNA auxiliary factor 2 | RNA polymerase II subunit E | |
Synonyms | U2AF65 | RPABC1|RPB5|XAP4|hRPB25|hsRPB5 | |
Cytomap | 19q13.42 | 19p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | splicing factor U2AF 65 kDa subunitU2 (RNU2) small nuclear RNA auxiliary factor 2U2 auxiliary factor 65 kDa subunitU2 small nuclear ribonucleoprotein auxiliary factor (65kD)U2 snRNP auxiliary factor large subunithU2AF65 | DNA-directed RNA polymerases I, II, and III subunit RPABC1DNA directed RNA polymerase II 23 kda polypeptideDNA-directed RNA polymerase II 23 kDa polypeptideDNA-directed RNA polymerase II subunit EDNA-directed RNA polymerase subunit RPABC1RNA polymera | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000450554, ENST00000308924, ENST00000590551, | ENST00000586746, ENST00000215587, ENST00000585838, | |
Fusion gene scores | * DoF score | 12 X 12 X 6=864 | 6 X 6 X 4=144 |
# samples | 13 | 8 | |
** MAII score | log2(13/864*10)=-2.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: U2AF2 [Title/Abstract] AND POLR2E [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | U2AF2(56172555)-POLR2E(1089550), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | U2AF2 | GO:0000398 | mRNA splicing, via spliceosome | 1824937 |
Hgene | U2AF2 | GO:0031397 | negative regulation of protein ubiquitination | 24389012 |
Hgene | U2AF2 | GO:0033120 | positive regulation of RNA splicing | 21536736 |
Hgene | U2AF2 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome | 15009664 |
Tgene | POLR2E | GO:0006366 | transcription by RNA polymerase II | 9852112 |
Fusion gene breakpoints across U2AF2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across POLR2E (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | OV | TCGA-13-0913 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - |
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Fusion Gene ORF analysis for U2AF2-POLR2E |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000450554 | ENST00000586746 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - |
In-frame | ENST00000450554 | ENST00000215587 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - |
5CDS-5UTR | ENST00000450554 | ENST00000585838 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - |
In-frame | ENST00000308924 | ENST00000586746 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - |
In-frame | ENST00000308924 | ENST00000215587 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - |
5CDS-5UTR | ENST00000308924 | ENST00000585838 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - |
intron-3CDS | ENST00000590551 | ENST00000586746 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - |
intron-3CDS | ENST00000590551 | ENST00000215587 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - |
intron-5UTR | ENST00000590551 | ENST00000585838 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000450554 | U2AF2 | chr19 | 56172555 | + | ENST00000586746 | POLR2E | chr19 | 1089550 | - | 1638 | 1445 | 878 | 99 | 259 |
ENST00000450554 | U2AF2 | chr19 | 56172555 | + | ENST00000215587 | POLR2E | chr19 | 1089550 | - | 2098 | 1445 | 878 | 99 | 259 |
ENST00000308924 | U2AF2 | chr19 | 56172555 | + | ENST00000586746 | POLR2E | chr19 | 1089550 | - | 719 | 526 | 10 | 591 | 193 |
ENST00000308924 | U2AF2 | chr19 | 56172555 | + | ENST00000215587 | POLR2E | chr19 | 1089550 | - | 1179 | 526 | 10 | 591 | 193 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000450554 | ENST00000586746 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - | 0.07327586 | 0.9267242 |
ENST00000450554 | ENST00000215587 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - | 0.070837155 | 0.9291628 |
ENST00000308924 | ENST00000586746 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - | 0.109366626 | 0.8906334 |
ENST00000308924 | ENST00000215587 | U2AF2 | chr19 | 56172555 | + | POLR2E | chr19 | 1089550 | - | 0.07795414 | 0.9220458 |
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Fusion Genomic Features for U2AF2-POLR2E |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for U2AF2-POLR2E |
Go to FGviewer for the breakpoints of chr19:56172555-chr19:1089550 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | U2AF2 | chr19:56172555 | chr19:1089550 | ENST00000308924 | + | 5 | 12 | 27_62 | 162.0 | 476.0 | Compositional bias | Note=Arg/Ser-rich (RS domain) |
Hgene | U2AF2 | chr19:56172555 | chr19:1089550 | ENST00000450554 | + | 5 | 12 | 27_62 | 162.0 | 472.0 | Compositional bias | Note=Arg/Ser-rich (RS domain) |
Hgene | U2AF2 | chr19:56172555 | chr19:1089550 | ENST00000308924 | + | 5 | 12 | 17_47 | 162.0 | 476.0 | Region | Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner |
Hgene | U2AF2 | chr19:56172555 | chr19:1089550 | ENST00000450554 | + | 5 | 12 | 17_47 | 162.0 | 472.0 | Region | Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | U2AF2 | chr19:56172555 | chr19:1089550 | ENST00000308924 | + | 5 | 12 | 149_231 | 162.0 | 476.0 | Domain | RRM 1 |
Hgene | U2AF2 | chr19:56172555 | chr19:1089550 | ENST00000308924 | + | 5 | 12 | 259_337 | 162.0 | 476.0 | Domain | RRM 2 |
Hgene | U2AF2 | chr19:56172555 | chr19:1089550 | ENST00000308924 | + | 5 | 12 | 385_466 | 162.0 | 476.0 | Domain | RRM 3 |
Hgene | U2AF2 | chr19:56172555 | chr19:1089550 | ENST00000450554 | + | 5 | 12 | 149_231 | 162.0 | 472.0 | Domain | RRM 1 |
Hgene | U2AF2 | chr19:56172555 | chr19:1089550 | ENST00000450554 | + | 5 | 12 | 259_337 | 162.0 | 472.0 | Domain | RRM 2 |
Hgene | U2AF2 | chr19:56172555 | chr19:1089550 | ENST00000450554 | + | 5 | 12 | 385_466 | 162.0 | 472.0 | Domain | RRM 3 |
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Fusion Gene Sequence for U2AF2-POLR2E |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000450554_ENST00000586746_TCGA-13-0913_U2AF2_chr19_56172555_+_POLR2E_chr19_1089550_length(transcript)=1638nt_BP=1445nt GCAACCTCCGCAGCGGTCGCGCGCACCCTTCATCCCTCTTGCTGCTTTTGTCTGGCACAACCTTCTCAGGCCCTCCGCGAGGCCGGCCCT TTTTTTCTTTCACTTTCCCCACCCGGAGAGCCAGGTGCCGAGAACTAGGACCTCGTCCCCTTCTCTATCCCTTCCCCTGATCCATCTCGT CTCTGTTCTCCTTCCCTTTTCCGTTCCCGAAGCCGGAAGGAGCCGAGGTACCCACGGAAAAAGTCGAAGCTGTCCCCGGAGAGTGAGGCC TTCACGAAGCGGTGGCGGAAGGAGCCGAAGTTCTCTGATCGGAGGCGTGAGCAAGTGGCATCTCCGGAAAGAGCCGAAACACGGACTCGA GCTTAATCCCAGGAGGGGCCCGAGGGCGAGATCCGGAAATCTCCGGAAAGAGCCGAAGGCCGGGACGGTTAGGATTGTCGGAAGTGGCCG ATTGCTTGGACAGGGCCGGCGGAGAAGATCGGAGCAAGTCCGTGGAAGAAGCCAAAGACTGGGACGGATTGAATTGTTGGAAGAACCCGA ACTCGCAGAGGGGACTGGGCGCAGTGGCACACGAGGACACACGGAAACCTCCGAACGTTGAGGAGATAATCTCGGAAAAGTTACGGAAAC CTGGGAAGTCGGCGAAACCCTACGTTCGGGTGTTTTCGGAAGCAGCCGAAGCGGCCGCCTGCTTCGCCTTCGTCCAGTATCCGGAGATAG CCGAGGCGCTTCGGAGCCAGGCTCGGGGGGAGGGGCAAGCTCGCGGGCGGGCGGGCGGGTGAGGGGGCGGAGCCCGGGCGGGGCGGGGAG GGCTGCCGGAGGCTTGATTAGGTAGGAGGTGGCGAAGCGCCGGCGGCGGCCGGAAGTAGCCGAAGCCAGCGGCGGAAGTAGCCGAAGCGG CTGGAGCGGGCGGCAAGGCGAGGCGAAAGCTGCACAGGGCCCTACGCGGCCGCCTCAGCATGTCGGACTTCGACGAGTTCGAGCGGCAGC TCAACGAGAATAAACAAGAGCGGGACAAGGAGAACCGGCATCGGAAGCGCAGCCACAGCCGCTCTCGGAGCCGGGACCGCAAACGCCGGA GCCGGAGCCGCGACCGGCGCAACCGGGACCAGCGGAGCGCCTCCCGGGACAGGCGACGACGCAGCAAACCTTTGACCAGAGGCGCTAAAG AGGAGCACGGTGGACTGATTCGTTCCCCCCGCCACGAGAAGAAGAAGAAGGTCCGTAAATACTGGGACGTGCCACCCCCAGGCTTTGAGC ACATCACCCCAATGCAGTACAAGGCCATGCAAGCTGCGGGTCAGATTCCAGCCACTGCTCTTCTCCCCACCATGACCCCTGACGGTCTGG CTGTGACCCCAACGCCGGTGCCCGTGGTCGGGAGCCAGATGACCAGACAAGCCCGGCGCCTCTACGTGGGCAACATCCCCTTTGGCATCA CTGAGGTGGTGAAGATCATCCGGCCCAGTGAGACGGCTGGCAGGTACATCACCTACCGGCTGGTGCAGTAGCTACCGCCTGACAGTTCCA CAGGCGCATGGGCCACGTTTCCAGTGCTTGGTGGCCATGTGGGGCTGACGTGCGAAACCTTAGAGCCGGGGGATACGTCCGTCATCGAGA >In-frame_ENST00000450554_ENST00000586746_TCGA-13-0913_U2AF2_chr19_56172555_+_POLR2E_chr19_1089550_length(amino acids)=259AA_start in transcript=878_stop in transcript=99 MASATSGRRRRFATSYLIKPPAALPAPPGLRPLTRPPARELAPPPEPGSEAPRLSPDTGRRRSRRPLRLLPKTPERRVSPTSQVSVTFPR LSPQRSEVSVCPRVPLRPVPSASSGSSNNSIRPSLWLLPRTCSDLLRRPCPSNRPLPTILTVPAFGSFRRFPDLALGPLLGLSSSPCFGS -------------------------------------------------------------- >In-frame_ENST00000450554_ENST00000215587_TCGA-13-0913_U2AF2_chr19_56172555_+_POLR2E_chr19_1089550_length(transcript)=2098nt_BP=1445nt GCAACCTCCGCAGCGGTCGCGCGCACCCTTCATCCCTCTTGCTGCTTTTGTCTGGCACAACCTTCTCAGGCCCTCCGCGAGGCCGGCCCT TTTTTTCTTTCACTTTCCCCACCCGGAGAGCCAGGTGCCGAGAACTAGGACCTCGTCCCCTTCTCTATCCCTTCCCCTGATCCATCTCGT CTCTGTTCTCCTTCCCTTTTCCGTTCCCGAAGCCGGAAGGAGCCGAGGTACCCACGGAAAAAGTCGAAGCTGTCCCCGGAGAGTGAGGCC TTCACGAAGCGGTGGCGGAAGGAGCCGAAGTTCTCTGATCGGAGGCGTGAGCAAGTGGCATCTCCGGAAAGAGCCGAAACACGGACTCGA GCTTAATCCCAGGAGGGGCCCGAGGGCGAGATCCGGAAATCTCCGGAAAGAGCCGAAGGCCGGGACGGTTAGGATTGTCGGAAGTGGCCG ATTGCTTGGACAGGGCCGGCGGAGAAGATCGGAGCAAGTCCGTGGAAGAAGCCAAAGACTGGGACGGATTGAATTGTTGGAAGAACCCGA ACTCGCAGAGGGGACTGGGCGCAGTGGCACACGAGGACACACGGAAACCTCCGAACGTTGAGGAGATAATCTCGGAAAAGTTACGGAAAC CTGGGAAGTCGGCGAAACCCTACGTTCGGGTGTTTTCGGAAGCAGCCGAAGCGGCCGCCTGCTTCGCCTTCGTCCAGTATCCGGAGATAG CCGAGGCGCTTCGGAGCCAGGCTCGGGGGGAGGGGCAAGCTCGCGGGCGGGCGGGCGGGTGAGGGGGCGGAGCCCGGGCGGGGCGGGGAG GGCTGCCGGAGGCTTGATTAGGTAGGAGGTGGCGAAGCGCCGGCGGCGGCCGGAAGTAGCCGAAGCCAGCGGCGGAAGTAGCCGAAGCGG CTGGAGCGGGCGGCAAGGCGAGGCGAAAGCTGCACAGGGCCCTACGCGGCCGCCTCAGCATGTCGGACTTCGACGAGTTCGAGCGGCAGC TCAACGAGAATAAACAAGAGCGGGACAAGGAGAACCGGCATCGGAAGCGCAGCCACAGCCGCTCTCGGAGCCGGGACCGCAAACGCCGGA GCCGGAGCCGCGACCGGCGCAACCGGGACCAGCGGAGCGCCTCCCGGGACAGGCGACGACGCAGCAAACCTTTGACCAGAGGCGCTAAAG AGGAGCACGGTGGACTGATTCGTTCCCCCCGCCACGAGAAGAAGAAGAAGGTCCGTAAATACTGGGACGTGCCACCCCCAGGCTTTGAGC ACATCACCCCAATGCAGTACAAGGCCATGCAAGCTGCGGGTCAGATTCCAGCCACTGCTCTTCTCCCCACCATGACCCCTGACGGTCTGG CTGTGACCCCAACGCCGGTGCCCGTGGTCGGGAGCCAGATGACCAGACAAGCCCGGCGCCTCTACGTGGGCAACATCCCCTTTGGCATCA CTGAGGTGGTGAAGATCATCCGGCCCAGTGAGACGGCTGGCAGGTACATCACCTACCGGCTGGTGCAGTAGCTACCGCCTGACAGCCCCT AGAGGCGGACACACAGCGACCCCCATCCCTGCAGGACAAACGCCCCTGCCCTGCCAGAATCCGGCCCCCACAGCTCTCACGGCTGCTGCT CCTCTGGACTCCCCAAGGCAGGTGGCCTCCACCCACGTTCTCCCGTCCTGGGGTGAGGCTTCCTGTGGCCCAGCCCGCCCCATTCACCTG TGGATTTGTGCGAGATGCAGCCTCAGAAGGAACAAGGCCCCCAGAGGGAGGTCACCTGGGGGCAGCTGGTGCCGGGTCTTCACCCAGACC ACGCTGGGTCCCCTCTGTTGGGGGTTTGGGGTCCGGGTCTCCCACCAGCCACTGCTTCCTCCTGGGCCCTCGGCCTTCCACCCCTCGTCT TCCCTCCCTCGGGGGCCCTGATGCGTGGCGGCCCCCGCCCGGCCTCGGCTCTTTACTCCATTCACAGCCATGCACGCGCTCAAGCCACCA GGGTGCGAGATGCCAGCTCTGGAGTTCTCGGTTGTTGTAGGAGGTTGGGTGTTTTCAAATGGTAAAGATGTTTTGAGCAAATAAATTTGC >In-frame_ENST00000450554_ENST00000215587_TCGA-13-0913_U2AF2_chr19_56172555_+_POLR2E_chr19_1089550_length(amino acids)=259AA_start in transcript=878_stop in transcript=99 MASATSGRRRRFATSYLIKPPAALPAPPGLRPLTRPPARELAPPPEPGSEAPRLSPDTGRRRSRRPLRLLPKTPERRVSPTSQVSVTFPR LSPQRSEVSVCPRVPLRPVPSASSGSSNNSIRPSLWLLPRTCSDLLRRPCPSNRPLPTILTVPAFGSFRRFPDLALGPLLGLSSSPCFGS -------------------------------------------------------------- >In-frame_ENST00000308924_ENST00000586746_TCGA-13-0913_U2AF2_chr19_56172555_+_POLR2E_chr19_1089550_length(transcript)=719nt_BP=526nt GAGGCGAAAGCTGCACAGGGCCCTACGCGGCCGCCTCAGCATGTCGGACTTCGACGAGTTCGAGCGGCAGCTCAACGAGAATAAACAAGA GCGGGACAAGGAGAACCGGCATCGGAAGCGCAGCCACAGCCGCTCTCGGAGCCGGGACCGCAAACGCCGGAGCCGGAGCCGCGACCGGCG CAACCGGGACCAGCGGAGCGCCTCCCGGGACAGGCGACGACGCAGCAAACCTTTGACCAGAGGCGCTAAAGAGGAGCACGGTGGACTGAT TCGTTCCCCCCGCCACGAGAAGAAGAAGAAGGTCCGTAAATACTGGGACGTGCCACCCCCAGGCTTTGAGCACATCACCCCAATGCAGTA CAAGGCCATGCAAGCTGCGGGTCAGATTCCAGCCACTGCTCTTCTCCCCACCATGACCCCTGACGGTCTGGCTGTGACCCCAACGCCGGT GCCCGTGGTCGGGAGCCAGATGACCAGACAAGCCCGGCGCCTCTACGTGGGCAACATCCCCTTTGGCATCACTGAGGTGGTGAAGATCAT CCGGCCCAGTGAGACGGCTGGCAGGTACATCACCTACCGGCTGGTGCAGTAGCTACCGCCTGACAGTTCCACAGGCGCATGGGCCACGTT >In-frame_ENST00000308924_ENST00000586746_TCGA-13-0913_U2AF2_chr19_56172555_+_POLR2E_chr19_1089550_length(amino acids)=193AA_start in transcript=10_stop in transcript=591 MHRALRGRLSMSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRRRSKPLTRGAKEEHGGLIRSP RHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEVVKIIRPS -------------------------------------------------------------- >In-frame_ENST00000308924_ENST00000215587_TCGA-13-0913_U2AF2_chr19_56172555_+_POLR2E_chr19_1089550_length(transcript)=1179nt_BP=526nt GAGGCGAAAGCTGCACAGGGCCCTACGCGGCCGCCTCAGCATGTCGGACTTCGACGAGTTCGAGCGGCAGCTCAACGAGAATAAACAAGA GCGGGACAAGGAGAACCGGCATCGGAAGCGCAGCCACAGCCGCTCTCGGAGCCGGGACCGCAAACGCCGGAGCCGGAGCCGCGACCGGCG CAACCGGGACCAGCGGAGCGCCTCCCGGGACAGGCGACGACGCAGCAAACCTTTGACCAGAGGCGCTAAAGAGGAGCACGGTGGACTGAT TCGTTCCCCCCGCCACGAGAAGAAGAAGAAGGTCCGTAAATACTGGGACGTGCCACCCCCAGGCTTTGAGCACATCACCCCAATGCAGTA CAAGGCCATGCAAGCTGCGGGTCAGATTCCAGCCACTGCTCTTCTCCCCACCATGACCCCTGACGGTCTGGCTGTGACCCCAACGCCGGT GCCCGTGGTCGGGAGCCAGATGACCAGACAAGCCCGGCGCCTCTACGTGGGCAACATCCCCTTTGGCATCACTGAGGTGGTGAAGATCAT CCGGCCCAGTGAGACGGCTGGCAGGTACATCACCTACCGGCTGGTGCAGTAGCTACCGCCTGACAGCCCCTAGAGGCGGACACACAGCGA CCCCCATCCCTGCAGGACAAACGCCCCTGCCCTGCCAGAATCCGGCCCCCACAGCTCTCACGGCTGCTGCTCCTCTGGACTCCCCAAGGC AGGTGGCCTCCACCCACGTTCTCCCGTCCTGGGGTGAGGCTTCCTGTGGCCCAGCCCGCCCCATTCACCTGTGGATTTGTGCGAGATGCA GCCTCAGAAGGAACAAGGCCCCCAGAGGGAGGTCACCTGGGGGCAGCTGGTGCCGGGTCTTCACCCAGACCACGCTGGGTCCCCTCTGTT GGGGGTTTGGGGTCCGGGTCTCCCACCAGCCACTGCTTCCTCCTGGGCCCTCGGCCTTCCACCCCTCGTCTTCCCTCCCTCGGGGGCCCT GATGCGTGGCGGCCCCCGCCCGGCCTCGGCTCTTTACTCCATTCACAGCCATGCACGCGCTCAAGCCACCAGGGTGCGAGATGCCAGCTC TGGAGTTCTCGGTTGTTGTAGGAGGTTGGGTGTTTTCAAATGGTAAAGATGTTTTGAGCAAATAAATTTGCTTGATACAGAAACCAGGCC >In-frame_ENST00000308924_ENST00000215587_TCGA-13-0913_U2AF2_chr19_56172555_+_POLR2E_chr19_1089550_length(amino acids)=193AA_start in transcript=10_stop in transcript=591 MHRALRGRLSMSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRRRSKPLTRGAKEEHGGLIRSP RHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEVVKIIRPS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for U2AF2-POLR2E |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for U2AF2-POLR2E |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for U2AF2-POLR2E |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |