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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:UBE2K-KLB (FusionGDB2 ID:95493) |
Fusion Gene Summary for UBE2K-KLB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2K-KLB | Fusion gene ID: 95493 | Hgene | Tgene | Gene symbol | UBE2K | KLB | Gene ID | 3093 | 152831 |
| Gene name | ubiquitin conjugating enzyme E2 K | klotho beta | |
| Synonyms | E2-25K|HIP2|HYPG|LIG|UBC1 | BKL | |
| Cytomap | 4p14 | 4p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiqu | beta-klothob-KlothobetaKlothoklotho beta likeklotho beta-like protein | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000261427, ENST00000295963, ENST00000438068, ENST00000503368, ENST00000445950, | ENST00000257408, | |
| Fusion gene scores | * DoF score | 13 X 7 X 10=910 | 3 X 2 X 3=18 |
| # samples | 17 | 3 | |
| ** MAII score | log2(17/910*10)=-2.42033179894836 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: UBE2K [Title/Abstract] AND KLB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | UBE2K(39776553)-KLB(39435830), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2K | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 24882218 |
| Hgene | UBE2K | GO:0010994 | free ubiquitin chain polymerization | 24882218 |
| Hgene | UBE2K | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
| Fusion gene breakpoints across UBE2K (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across KLB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-BH-A1FD-01A | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + |
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Fusion Gene ORF analysis for UBE2K-KLB |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261427 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + |
| intron-3CDS | ENST00000295963 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + |
| 3UTR-3CDS | ENST00000438068 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + |
| In-frame | ENST00000503368 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + |
| In-frame | ENST00000445950 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000261427 | UBE2K | chr4 | 39776553 | + | ENST00000257408 | KLB | chr4 | 39435830 | + | 5843 | 683 | 284 | 2992 | 902 |
| ENST00000503368 | UBE2K | chr4 | 39776553 | + | ENST00000257408 | KLB | chr4 | 39435830 | + | 5571 | 411 | 165 | 2720 | 851 |
| ENST00000445950 | UBE2K | chr4 | 39776553 | + | ENST00000257408 | KLB | chr4 | 39435830 | + | 5711 | 551 | 152 | 2860 | 902 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000261427 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + | 0.000286982 | 0.999713 |
| ENST00000503368 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + | 0.000760363 | 0.9992397 |
| ENST00000445950 | ENST00000257408 | UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435830 | + | 0.000283195 | 0.9997168 |
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Fusion Genomic Features for UBE2K-KLB |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435829 | + | 1.29E-09 | 1 |
| UBE2K | chr4 | 39776553 | + | KLB | chr4 | 39435829 | + | 1.29E-09 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for UBE2K-KLB |
| Go to FGviewer for the breakpoints of chr4:39776553-chr4:39435830 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KLB | chr4:39776553 | chr4:39435830 | ENST00000257408 | 0 | 5 | 517_967 | 275.0 | 1045.0 | Region | Note=Glycosyl hydrolase-1 2 | |
| Tgene | KLB | chr4:39776553 | chr4:39435830 | ENST00000257408 | 0 | 5 | 1018_1044 | 275.0 | 1045.0 | Topological domain | Cytoplasmic | |
| Tgene | KLB | chr4:39776553 | chr4:39435830 | ENST00000257408 | 0 | 5 | 997_1017 | 275.0 | 1045.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | UBE2K | chr4:39776553 | chr4:39435830 | ENST00000261427 | + | 5 | 7 | 160_200 | 133.0 | 201.0 | Domain | UBA |
| Hgene | UBE2K | chr4:39776553 | chr4:39435830 | ENST00000261427 | + | 5 | 7 | 4_154 | 133.0 | 201.0 | Domain | UBC core |
| Hgene | UBE2K | chr4:39776553 | chr4:39435830 | ENST00000445950 | + | 5 | 6 | 160_200 | 133.0 | 158.0 | Domain | UBA |
| Hgene | UBE2K | chr4:39776553 | chr4:39435830 | ENST00000445950 | + | 5 | 6 | 4_154 | 133.0 | 158.0 | Domain | UBC core |
| Hgene | UBE2K | chr4:39776553 | chr4:39435830 | ENST00000503368 | + | 3 | 5 | 160_200 | 82.0 | 150.0 | Domain | UBA |
| Hgene | UBE2K | chr4:39776553 | chr4:39435830 | ENST00000503368 | + | 3 | 5 | 4_154 | 82.0 | 150.0 | Domain | UBC core |
| Tgene | KLB | chr4:39776553 | chr4:39435830 | ENST00000257408 | 0 | 5 | 77_508 | 275.0 | 1045.0 | Region | Note=Glycosyl hydrolase-1 1 | |
| Tgene | KLB | chr4:39776553 | chr4:39435830 | ENST00000257408 | 0 | 5 | 1_996 | 275.0 | 1045.0 | Topological domain | Extracellular |
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Fusion Gene Sequence for UBE2K-KLB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000261427_ENST00000257408_TCGA-BH-A1FD-01A_UBE2K_chr4_39776553_+_KLB_chr4_39435830_length(transcript)=5843nt_BP=683nt ACGCGAGCTCGTGGCTCGGGCGTATGGGGGCTCCAACGGGAGCGGCTGCGCCGCCCGGCCGGGTCAACGTCGTGCGCATGCGCCGACCCG GCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGG TCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAG CTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATC AAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAAGAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGAT ACCAACTAGAGATAAAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTT CCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGGGCAGCTGCAATGACTCTCCGCACGGTATTATTGTCATTGCAAGCAC TATTGGCAGCTGCAGAGCCAGATGATCCACAGGATGCTGTAGTAGCAAATCAGGCTCACTCGAAAGTTTGGCATAACTACAACACACATT TCCGCCCACATCAGAAGGGTTGGTTATCGATCACGTTGGGATCTCATTGGATCGAGCCAAACCGGTCGGAAAACACGATGGATATATTCA AATGTCAACAATCCATGGTTTCTGTGCTTGGATGGTTTGCCAACCCTATCCATGGGGATGGCGACTATCCAGAGGGGATGAGAAAGAAGT TGTTCTCCGTTCTACCCATTTTCTCTGAAGCAGAGAAGCATGAGATGAGAGGCACAGCTGATTTCTTTGCCTTTTCTTTTGGACCCAACA ACTTCAAGCCCCTAAACACCATGGCTAAAATGGGACAAAATGTTTCACTTAATTTAAGAGAAGCGCTGAACTGGATTAAACTGGAATACA ACAACCCTCGAATCTTGATTGCTGAGAATGGCTGGTTCACAGACAGTCGTGTGAAAACAGAAGACACCACGGCCATCTACATGATGAAGA ATTTCCTCAGCCAGGTGCTTCAAGCAATAAGGTTAGATGAAATACGAGTGTTTGGTTATACTGCCTGGTCTCTCCTGGATGGCTTTGAAT GGCAGGATGCTTACACCATCCGCCGAGGATTATTTTATGTGGATTTTAACAGTAAACAGAAAGAGCGGAAACCTAAGTCTTCAGCACACT ACTACAAACAGATCATACGAGAAAATGGTTTTTCTTTAAAAGAGTCCACGCCAGATGTGCAGGGCCAGTTTCCCTGTGACTTCTCCTGGG GTGTCACTGAATCTGTTCTTAAGCCCGAGTCTGTGGCTTCGTCCCCACAGTTCAGCGATCCTCATCTGTACGTGTGGAACGCCACTGGCA ACAGACTGTTGCACCGAGTGGAAGGGGTGAGGCTGAAAACACGACCCGCTCAATGCACAGATTTTGTAAACATCAAAAAACAACTTGAGA TGTTGGCAAGAATGAAAGTCACCCACTACCGGTTTGCTCTGGATTGGGCCTCGGTCCTTCCCACTGGCAACCTGTCCGCGGTGAACCGAC AGGCCCTGAGGTACTACAGGTGCGTGGTCAGTGAGGGGCTGAAGCTTGGCATCTCCGCGATGGTCACCCTGTATTATCCGACCCACGCCC ACCTAGGCCTCCCCGAGCCTCTGTTGCATGCCGACGGGTGGCTGAACCCATCGACGGCCGAGGCCTTCCAGGCCTACGCTGGGCTGTGCT TCCAGGAGCTGGGGGACCTGGTGAAGCTCTGGATCACCATCAACGAGCCTAACCGGCTAAGTGACATCTACAACCGCTCTGGCAACGACA CCTACGGGGCGGCGCACAACCTGCTGGTGGCCCACGCCCTGGCCTGGCGCCTCTACGACCGGCAGTTCAGGCCCTCACAGCGCGGGGCCG TGTCGCTGTCGCTGCACGCGGACTGGGCGGAACCCGCCAACCCCTATGCTGACTCGCACTGGAGGGCGGCCGAGCGCTTCCTGCAGTTCG AGATCGCCTGGTTCGCCGAGCCGCTCTTCAAGACCGGGGACTACCCCGCGGCCATGAGGGAATACATTGCCTCCAAGCACCGACGGGGGC TTTCCAGCTCGGCCCTGCCGCGCCTCACCGAGGCCGAAAGGAGGCTGCTCAAGGGCACGGTCGACTTCTGCGCGCTCAACCACTTCACCA CTAGGTTCGTGATGCACGAGCAGCTGGCCGGCAGCCGCTACGACTCGGACAGGGACATCCAGTTTCTGCAGGACATCACCCGCCTGAGCT CCCCCACGCGCCTGGCTGTGATTCCCTGGGGGGTGCGCAAGCTGCTGCGGTGGGTCCGGAGGAACTACGGCGACATGGACATTTACATCA CCGCCAGTGGCATCGACGACCAGGCTCTGGAGGATGACCGGCTCCGGAAGTACTACCTAGGGAAGTACCTTCAGGAGGTGCTGAAAGCAT ACCTGATTGATAAAGTCAGAATCAAAGGCTATTATGCATTCAAACTGGCTGAAGAGAAATCTAAACCCAGATTTGGATTCTTCACATCTG ATTTTAAAGCTAAATCCTCAATACAATTTTACAACAAAGTGATCAGCAGCAGGGGCTTCCCTTTTGAGAACAGTAGTTCTAGATGCAGTC AGACCCAAGAAAATACAGAGTGCACTGTCTGCTTATTCCTTGTGCAGAAGAAACCACTGATATTCCTGGGTTGTTGCTTCTTCTCCACCC TGGTTCTACTCTTATCAATTGCCATTTTTCAAAGGCAGAAGAGAAGAAAGTTTTGGAAAGCAAAAAACTTACAACACATACCATTAAAGA AAGGCAAGAGAGTTGTTAGCTAAACTGATCTGTCTGCATGATAGACAGTTTAAAAATTCATCCCAGTTCCATATGCTGGTAACTTACAGG AGATATACCTGTATTATAGAAAGACAATCTGAGATACAGCTGTAACCAAGGTGATGACAATTGTCTCTGCTGTGTGGTTCAAAGAACATT CCCTTAGGTGTTGACATCAGTGAACTCAGTTCTTGGATGTAAACATAAAGGCTTCATCCTGACAGTAAGCTATGAGGATTACATGCTACA TTGCTTCTTAAAGTTTCATCAACTGTATTCCATCATTCTGCTTTAGCTTTCATCTCTACCAATAGCTACTTGTGGTACAATAAATTATTT TTAAGAAGTAAAACTCTGGGGCTGGACGCTGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCCGAGGCGGGGAGATCACCTGAGGT GAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCATGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGACAGTGGCACC TGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAAGTTTGAACCCAGGAAACAGGTTACAGTAGGCCAAAATTGCGCCACTGCACTCCAGC CTAGGCGACAACAGCAAGACTGTGTCCAAAAAAAAAAAAAAAAGCAAAAGCAAAACTTTGTTTTGTTAGACTCTACAGCAGAGATTTAAC ACCCTTCTTTAAACTGGGTAGTCAGTGATAGATAATATATATTCTGTCACTTCTAATAAGGTGCCTTCTCCTTTAGGTCAGGGTGGTTCT AAAATGGAAAGAAAACACAATAGGGTAAGTAGTGCTTGTCTAAGCCAGTTACAACACAGACTCTTAAAGAGGATCAAGCCCTTCATTTTT CTAACAACAAAAAATCACCTATAGAATATCTAATTTGTGATCTTTTACTAGATCTGATTTTTTAAAATAATGTAATTTCCGGCCAGGCAC GGTGGCACCGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTTAGGAGTTCGAGACTAGCCTGGCCAACATG GCAAAACCCCATCTCTACTAAAAATACAAAAGTTAGCCGGGCATGGTGGTGGGCACCTGTAATCCCAGCTACTCAGGAGGCCGAGGCAGG AGAATCGCTTGAACCCGAGAGGCAGAGGTTGCAATGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGGGACAGGGCAAGACTGTCTCT CAAAATAAAAAAAAATAATAAAAATAAAAATAAAAGTAATTTCCAAAACCTCATCTCATGGAAAGATCACAGGATGAAGGAAAGCTAGAC TCAACTCTGTGAATAGAAGTTGCTATACTGTAAGTAAAGCAACAATTCAGAATACTGAATGAGTTTAAATTGTTTTATATAGCACCCTTT TGGGCTAGGGTTAATTACTAGATCTGACTTGGATAATTTGACACTTTGGGAAATGAACTCTGTTCTTGAGACTTGTTCAGTGTATTTTAA ACATCTGAGGAAGAAAACTTAAATATGCACCTATTTATACCTATTCTTTCTTTAGGTCAACATTTAACACCCACTGCATACATTAATTTG TCCTTGTCTGCTCACTCCAGCAATTTAGACCTTAACAGTCACAAGAGACGTTCTTCTGTTACAAAGCCTTAGTAAATTAAGGCAGTTTTG ATTATATTCTAGGTCCACCTATGTCTGAAGCTAAATTCAGTATCTAACTGCTAATGAACAAGTTTCCAAAATACTGTAAAAATACAATTA GTCAATTTGAGTAAATGCAAATATGATGAGAAATCAATTTGCTATTTGGCCTGGCAAATGGGAACAGTAAAATTCTGCTTTACTCTTCTC TAGTCTCCTTGCCCCAGCTGCACCCACTACCCCAAAGTTGGCAGTTTTGAGGTATGATTTTCAAGGAATTTTTTTAGTATTAACATCTCC CTCTGAGAACTATGTACCTAAGGTCACGCATACAACTAGTCAATTCTGTTTTTATTACTCTAACTATGTAGAAACAGTAAGTCACTTAAA ACAATCACTTGGCTGGGTTTTTTCCCCTTTGTGCCACATTGATTCACCCTGACCCAAGAACTCCAGGGAAAATTCTTTAATGTCAACTGG GCAACTCATTAACCTCTCTTTAACATCAAGGGCTTGGGAAAAAAAAAAAAAAGGTTAGCCACAGGAATAACAAAAACCTGGAATTTATCT TTCAGGTTTTGCTTTCTCTTTCTCACTTTGTTTAAAGTATCTCGTACTCACAGTTCACAAATTAACCTTCACTGTCTCTTTCACATTAAG AGCTTATGCTTAAAGCATGCCCCCCTTTTCTAACTTGCTGGTTTACCATAAACTCCCCTAAGTAATAAAATTCCTAACCCAGTACTGAGA GTCCTCCTTCTCTGCCACTTGGGCATTATTTTACTAGTTTTTAAGCCATCATCGCACAAGAATCCAAAAACCCTTAAATTTTTTAACCAC TGGCAAATATGTACAGCAAATTAGGTTAAGCATTTAATCTGGCTCATGCTCTATCATACTAAATATTCAGGTTTATCATAAACTCCTTAA AAACCATCAAAGGTCAACCAGAAACTGATAACTCTTGAAAGGAGCAAACAGGTAAGATCTTTGGAGTTTAAGCTTTTCTGAGATGTGTTG TGAAAAATCTAACGTGTTTATCGTATATTCAATGTAACAACCTGGAGAATCACAACTATATTTAAAGAGCCTCTGGAAAATGAGGCCAGT >In-frame_ENST00000261427_ENST00000257408_TCGA-BH-A1FD-01A_UBE2K_chr4_39776553_+_KLB_chr4_39435830_length(amino acids)=902AA_start in transcript=284_stop in transcript=2992 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGA ICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQS MVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRI LIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQI IRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARM KVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELG DLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWF AEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRL AVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAK SSIQFYNKVISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFSTLVLLLSIAIFQRQKRRKFWKAKNLQHIPLKKGKRV -------------------------------------------------------------- >In-frame_ENST00000503368_ENST00000257408_TCGA-BH-A1FD-01A_UBE2K_chr4_39776553_+_KLB_chr4_39435830_length(transcript)=5571nt_BP=411nt GATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGA GGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCG GTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCC GTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGGGCAGCTGCAATGACTCTCCGCACGGTATTATTGTCATTGCAAGCACTA TTGGCAGCTGCAGAGCCAGATGATCCACAGGATGCTGTAGTAGCAAATCAGGCTCACTCGAAAGTTTGGCATAACTACAACACACATTTC CGCCCACATCAGAAGGGTTGGTTATCGATCACGTTGGGATCTCATTGGATCGAGCCAAACCGGTCGGAAAACACGATGGATATATTCAAA TGTCAACAATCCATGGTTTCTGTGCTTGGATGGTTTGCCAACCCTATCCATGGGGATGGCGACTATCCAGAGGGGATGAGAAAGAAGTTG TTCTCCGTTCTACCCATTTTCTCTGAAGCAGAGAAGCATGAGATGAGAGGCACAGCTGATTTCTTTGCCTTTTCTTTTGGACCCAACAAC TTCAAGCCCCTAAACACCATGGCTAAAATGGGACAAAATGTTTCACTTAATTTAAGAGAAGCGCTGAACTGGATTAAACTGGAATACAAC AACCCTCGAATCTTGATTGCTGAGAATGGCTGGTTCACAGACAGTCGTGTGAAAACAGAAGACACCACGGCCATCTACATGATGAAGAAT TTCCTCAGCCAGGTGCTTCAAGCAATAAGGTTAGATGAAATACGAGTGTTTGGTTATACTGCCTGGTCTCTCCTGGATGGCTTTGAATGG CAGGATGCTTACACCATCCGCCGAGGATTATTTTATGTGGATTTTAACAGTAAACAGAAAGAGCGGAAACCTAAGTCTTCAGCACACTAC TACAAACAGATCATACGAGAAAATGGTTTTTCTTTAAAAGAGTCCACGCCAGATGTGCAGGGCCAGTTTCCCTGTGACTTCTCCTGGGGT GTCACTGAATCTGTTCTTAAGCCCGAGTCTGTGGCTTCGTCCCCACAGTTCAGCGATCCTCATCTGTACGTGTGGAACGCCACTGGCAAC AGACTGTTGCACCGAGTGGAAGGGGTGAGGCTGAAAACACGACCCGCTCAATGCACAGATTTTGTAAACATCAAAAAACAACTTGAGATG TTGGCAAGAATGAAAGTCACCCACTACCGGTTTGCTCTGGATTGGGCCTCGGTCCTTCCCACTGGCAACCTGTCCGCGGTGAACCGACAG GCCCTGAGGTACTACAGGTGCGTGGTCAGTGAGGGGCTGAAGCTTGGCATCTCCGCGATGGTCACCCTGTATTATCCGACCCACGCCCAC CTAGGCCTCCCCGAGCCTCTGTTGCATGCCGACGGGTGGCTGAACCCATCGACGGCCGAGGCCTTCCAGGCCTACGCTGGGCTGTGCTTC CAGGAGCTGGGGGACCTGGTGAAGCTCTGGATCACCATCAACGAGCCTAACCGGCTAAGTGACATCTACAACCGCTCTGGCAACGACACC TACGGGGCGGCGCACAACCTGCTGGTGGCCCACGCCCTGGCCTGGCGCCTCTACGACCGGCAGTTCAGGCCCTCACAGCGCGGGGCCGTG TCGCTGTCGCTGCACGCGGACTGGGCGGAACCCGCCAACCCCTATGCTGACTCGCACTGGAGGGCGGCCGAGCGCTTCCTGCAGTTCGAG ATCGCCTGGTTCGCCGAGCCGCTCTTCAAGACCGGGGACTACCCCGCGGCCATGAGGGAATACATTGCCTCCAAGCACCGACGGGGGCTT TCCAGCTCGGCCCTGCCGCGCCTCACCGAGGCCGAAAGGAGGCTGCTCAAGGGCACGGTCGACTTCTGCGCGCTCAACCACTTCACCACT AGGTTCGTGATGCACGAGCAGCTGGCCGGCAGCCGCTACGACTCGGACAGGGACATCCAGTTTCTGCAGGACATCACCCGCCTGAGCTCC CCCACGCGCCTGGCTGTGATTCCCTGGGGGGTGCGCAAGCTGCTGCGGTGGGTCCGGAGGAACTACGGCGACATGGACATTTACATCACC GCCAGTGGCATCGACGACCAGGCTCTGGAGGATGACCGGCTCCGGAAGTACTACCTAGGGAAGTACCTTCAGGAGGTGCTGAAAGCATAC CTGATTGATAAAGTCAGAATCAAAGGCTATTATGCATTCAAACTGGCTGAAGAGAAATCTAAACCCAGATTTGGATTCTTCACATCTGAT TTTAAAGCTAAATCCTCAATACAATTTTACAACAAAGTGATCAGCAGCAGGGGCTTCCCTTTTGAGAACAGTAGTTCTAGATGCAGTCAG ACCCAAGAAAATACAGAGTGCACTGTCTGCTTATTCCTTGTGCAGAAGAAACCACTGATATTCCTGGGTTGTTGCTTCTTCTCCACCCTG GTTCTACTCTTATCAATTGCCATTTTTCAAAGGCAGAAGAGAAGAAAGTTTTGGAAAGCAAAAAACTTACAACACATACCATTAAAGAAA GGCAAGAGAGTTGTTAGCTAAACTGATCTGTCTGCATGATAGACAGTTTAAAAATTCATCCCAGTTCCATATGCTGGTAACTTACAGGAG ATATACCTGTATTATAGAAAGACAATCTGAGATACAGCTGTAACCAAGGTGATGACAATTGTCTCTGCTGTGTGGTTCAAAGAACATTCC CTTAGGTGTTGACATCAGTGAACTCAGTTCTTGGATGTAAACATAAAGGCTTCATCCTGACAGTAAGCTATGAGGATTACATGCTACATT GCTTCTTAAAGTTTCATCAACTGTATTCCATCATTCTGCTTTAGCTTTCATCTCTACCAATAGCTACTTGTGGTACAATAAATTATTTTT AAGAAGTAAAACTCTGGGGCTGGACGCTGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGCCGAGGCGGGGAGATCACCTGAGGTGA GGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCATGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGACAGTGGCACCTG TAATCCCAGCTACTTGGGAGGCTGAGGCAGAAGTTTGAACCCAGGAAACAGGTTACAGTAGGCCAAAATTGCGCCACTGCACTCCAGCCT AGGCGACAACAGCAAGACTGTGTCCAAAAAAAAAAAAAAAAGCAAAAGCAAAACTTTGTTTTGTTAGACTCTACAGCAGAGATTTAACAC CCTTCTTTAAACTGGGTAGTCAGTGATAGATAATATATATTCTGTCACTTCTAATAAGGTGCCTTCTCCTTTAGGTCAGGGTGGTTCTAA AATGGAAAGAAAACACAATAGGGTAAGTAGTGCTTGTCTAAGCCAGTTACAACACAGACTCTTAAAGAGGATCAAGCCCTTCATTTTTCT AACAACAAAAAATCACCTATAGAATATCTAATTTGTGATCTTTTACTAGATCTGATTTTTTAAAATAATGTAATTTCCGGCCAGGCACGG TGGCACCGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTTAGGAGTTCGAGACTAGCCTGGCCAACATGGC AAAACCCCATCTCTACTAAAAATACAAAAGTTAGCCGGGCATGGTGGTGGGCACCTGTAATCCCAGCTACTCAGGAGGCCGAGGCAGGAG AATCGCTTGAACCCGAGAGGCAGAGGTTGCAATGAGCCAAGATCGTGCCATTGCACTCCAGCCTGGGGGACAGGGCAAGACTGTCTCTCA AAATAAAAAAAAATAATAAAAATAAAAATAAAAGTAATTTCCAAAACCTCATCTCATGGAAAGATCACAGGATGAAGGAAAGCTAGACTC AACTCTGTGAATAGAAGTTGCTATACTGTAAGTAAAGCAACAATTCAGAATACTGAATGAGTTTAAATTGTTTTATATAGCACCCTTTTG GGCTAGGGTTAATTACTAGATCTGACTTGGATAATTTGACACTTTGGGAAATGAACTCTGTTCTTGAGACTTGTTCAGTGTATTTTAAAC ATCTGAGGAAGAAAACTTAAATATGCACCTATTTATACCTATTCTTTCTTTAGGTCAACATTTAACACCCACTGCATACATTAATTTGTC CTTGTCTGCTCACTCCAGCAATTTAGACCTTAACAGTCACAAGAGACGTTCTTCTGTTACAAAGCCTTAGTAAATTAAGGCAGTTTTGAT TATATTCTAGGTCCACCTATGTCTGAAGCTAAATTCAGTATCTAACTGCTAATGAACAAGTTTCCAAAATACTGTAAAAATACAATTAGT CAATTTGAGTAAATGCAAATATGATGAGAAATCAATTTGCTATTTGGCCTGGCAAATGGGAACAGTAAAATTCTGCTTTACTCTTCTCTA GTCTCCTTGCCCCAGCTGCACCCACTACCCCAAAGTTGGCAGTTTTGAGGTATGATTTTCAAGGAATTTTTTTAGTATTAACATCTCCCT CTGAGAACTATGTACCTAAGGTCACGCATACAACTAGTCAATTCTGTTTTTATTACTCTAACTATGTAGAAACAGTAAGTCACTTAAAAC AATCACTTGGCTGGGTTTTTTCCCCTTTGTGCCACATTGATTCACCCTGACCCAAGAACTCCAGGGAAAATTCTTTAATGTCAACTGGGC AACTCATTAACCTCTCTTTAACATCAAGGGCTTGGGAAAAAAAAAAAAAAGGTTAGCCACAGGAATAACAAAAACCTGGAATTTATCTTT CAGGTTTTGCTTTCTCTTTCTCACTTTGTTTAAAGTATCTCGTACTCACAGTTCACAAATTAACCTTCACTGTCTCTTTCACATTAAGAG CTTATGCTTAAAGCATGCCCCCCTTTTCTAACTTGCTGGTTTACCATAAACTCCCCTAAGTAATAAAATTCCTAACCCAGTACTGAGAGT CCTCCTTCTCTGCCACTTGGGCATTATTTTACTAGTTTTTAAGCCATCATCGCACAAGAATCCAAAAACCCTTAAATTTTTTAACCACTG GCAAATATGTACAGCAAATTAGGTTAAGCATTTAATCTGGCTCATGCTCTATCATACTAAATATTCAGGTTTATCATAAACTCCTTAAAA ACCATCAAAGGTCAACCAGAAACTGATAACTCTTGAAAGGAGCAAACAGGTAAGATCTTTGGAGTTTAAGCTTTTCTGAGATGTGTTGTG AAAAATCTAACGTGTTTATCGTATATTCAATGTAACAACCTGGAGAATCACAACTATATTTAAAGAGCCTCTGGAAAATGAGGCCAGTAC >In-frame_ENST00000503368_ENST00000257408_TCGA-BH-A1FD-01A_UBE2K_chr4_39776553_+_KLB_chr4_39435830_length(amino acids)=851AA_start in transcript=165_stop in transcript=2720 MANIAVQRIKREFKEVLKSEEVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQAHSKVWHN YNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFS FGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLL DGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVW NATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYY PTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPS QRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCAL NHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQE VLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCC -------------------------------------------------------------- >In-frame_ENST00000445950_ENST00000257408_TCGA-BH-A1FD-01A_UBE2K_chr4_39776553_+_KLB_chr4_39435830_length(transcript)=5711nt_BP=551nt GGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCG GCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCA AGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATCAAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAA GAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATAAAAATACCAGAAACATACCCATTTAATC CCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAAT GGGCAGCTGCAATGACTCTCCGCACGGTATTATTGTCATTGCAAGCACTATTGGCAGCTGCAGAGCCAGATGATCCACAGGATGCTGTAG TAGCAAATCAGGCTCACTCGAAAGTTTGGCATAACTACAACACACATTTCCGCCCACATCAGAAGGGTTGGTTATCGATCACGTTGGGAT CTCATTGGATCGAGCCAAACCGGTCGGAAAACACGATGGATATATTCAAATGTCAACAATCCATGGTTTCTGTGCTTGGATGGTTTGCCA ACCCTATCCATGGGGATGGCGACTATCCAGAGGGGATGAGAAAGAAGTTGTTCTCCGTTCTACCCATTTTCTCTGAAGCAGAGAAGCATG AGATGAGAGGCACAGCTGATTTCTTTGCCTTTTCTTTTGGACCCAACAACTTCAAGCCCCTAAACACCATGGCTAAAATGGGACAAAATG TTTCACTTAATTTAAGAGAAGCGCTGAACTGGATTAAACTGGAATACAACAACCCTCGAATCTTGATTGCTGAGAATGGCTGGTTCACAG ACAGTCGTGTGAAAACAGAAGACACCACGGCCATCTACATGATGAAGAATTTCCTCAGCCAGGTGCTTCAAGCAATAAGGTTAGATGAAA TACGAGTGTTTGGTTATACTGCCTGGTCTCTCCTGGATGGCTTTGAATGGCAGGATGCTTACACCATCCGCCGAGGATTATTTTATGTGG ATTTTAACAGTAAACAGAAAGAGCGGAAACCTAAGTCTTCAGCACACTACTACAAACAGATCATACGAGAAAATGGTTTTTCTTTAAAAG AGTCCACGCCAGATGTGCAGGGCCAGTTTCCCTGTGACTTCTCCTGGGGTGTCACTGAATCTGTTCTTAAGCCCGAGTCTGTGGCTTCGT CCCCACAGTTCAGCGATCCTCATCTGTACGTGTGGAACGCCACTGGCAACAGACTGTTGCACCGAGTGGAAGGGGTGAGGCTGAAAACAC GACCCGCTCAATGCACAGATTTTGTAAACATCAAAAAACAACTTGAGATGTTGGCAAGAATGAAAGTCACCCACTACCGGTTTGCTCTGG ATTGGGCCTCGGTCCTTCCCACTGGCAACCTGTCCGCGGTGAACCGACAGGCCCTGAGGTACTACAGGTGCGTGGTCAGTGAGGGGCTGA AGCTTGGCATCTCCGCGATGGTCACCCTGTATTATCCGACCCACGCCCACCTAGGCCTCCCCGAGCCTCTGTTGCATGCCGACGGGTGGC TGAACCCATCGACGGCCGAGGCCTTCCAGGCCTACGCTGGGCTGTGCTTCCAGGAGCTGGGGGACCTGGTGAAGCTCTGGATCACCATCA ACGAGCCTAACCGGCTAAGTGACATCTACAACCGCTCTGGCAACGACACCTACGGGGCGGCGCACAACCTGCTGGTGGCCCACGCCCTGG CCTGGCGCCTCTACGACCGGCAGTTCAGGCCCTCACAGCGCGGGGCCGTGTCGCTGTCGCTGCACGCGGACTGGGCGGAACCCGCCAACC CCTATGCTGACTCGCACTGGAGGGCGGCCGAGCGCTTCCTGCAGTTCGAGATCGCCTGGTTCGCCGAGCCGCTCTTCAAGACCGGGGACT ACCCCGCGGCCATGAGGGAATACATTGCCTCCAAGCACCGACGGGGGCTTTCCAGCTCGGCCCTGCCGCGCCTCACCGAGGCCGAAAGGA GGCTGCTCAAGGGCACGGTCGACTTCTGCGCGCTCAACCACTTCACCACTAGGTTCGTGATGCACGAGCAGCTGGCCGGCAGCCGCTACG ACTCGGACAGGGACATCCAGTTTCTGCAGGACATCACCCGCCTGAGCTCCCCCACGCGCCTGGCTGTGATTCCCTGGGGGGTGCGCAAGC TGCTGCGGTGGGTCCGGAGGAACTACGGCGACATGGACATTTACATCACCGCCAGTGGCATCGACGACCAGGCTCTGGAGGATGACCGGC TCCGGAAGTACTACCTAGGGAAGTACCTTCAGGAGGTGCTGAAAGCATACCTGATTGATAAAGTCAGAATCAAAGGCTATTATGCATTCA AACTGGCTGAAGAGAAATCTAAACCCAGATTTGGATTCTTCACATCTGATTTTAAAGCTAAATCCTCAATACAATTTTACAACAAAGTGA TCAGCAGCAGGGGCTTCCCTTTTGAGAACAGTAGTTCTAGATGCAGTCAGACCCAAGAAAATACAGAGTGCACTGTCTGCTTATTCCTTG TGCAGAAGAAACCACTGATATTCCTGGGTTGTTGCTTCTTCTCCACCCTGGTTCTACTCTTATCAATTGCCATTTTTCAAAGGCAGAAGA GAAGAAAGTTTTGGAAAGCAAAAAACTTACAACACATACCATTAAAGAAAGGCAAGAGAGTTGTTAGCTAAACTGATCTGTCTGCATGAT AGACAGTTTAAAAATTCATCCCAGTTCCATATGCTGGTAACTTACAGGAGATATACCTGTATTATAGAAAGACAATCTGAGATACAGCTG TAACCAAGGTGATGACAATTGTCTCTGCTGTGTGGTTCAAAGAACATTCCCTTAGGTGTTGACATCAGTGAACTCAGTTCTTGGATGTAA ACATAAAGGCTTCATCCTGACAGTAAGCTATGAGGATTACATGCTACATTGCTTCTTAAAGTTTCATCAACTGTATTCCATCATTCTGCT TTAGCTTTCATCTCTACCAATAGCTACTTGTGGTACAATAAATTATTTTTAAGAAGTAAAACTCTGGGGCTGGACGCTGTGGCTCACACC TGTAATCTCAGCACTTTGGGAGGCCGAGGCGGGGAGATCACCTGAGGTGAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCATGT CTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGACAGTGGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAAGTTTGAAC CCAGGAAACAGGTTACAGTAGGCCAAAATTGCGCCACTGCACTCCAGCCTAGGCGACAACAGCAAGACTGTGTCCAAAAAAAAAAAAAAA AGCAAAAGCAAAACTTTGTTTTGTTAGACTCTACAGCAGAGATTTAACACCCTTCTTTAAACTGGGTAGTCAGTGATAGATAATATATAT TCTGTCACTTCTAATAAGGTGCCTTCTCCTTTAGGTCAGGGTGGTTCTAAAATGGAAAGAAAACACAATAGGGTAAGTAGTGCTTGTCTA AGCCAGTTACAACACAGACTCTTAAAGAGGATCAAGCCCTTCATTTTTCTAACAACAAAAAATCACCTATAGAATATCTAATTTGTGATC TTTTACTAGATCTGATTTTTTAAAATAATGTAATTTCCGGCCAGGCACGGTGGCACCGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGC AGGTGGATCACCTGAGGTTAGGAGTTCGAGACTAGCCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAGTTAGCCGGGC ATGGTGGTGGGCACCTGTAATCCCAGCTACTCAGGAGGCCGAGGCAGGAGAATCGCTTGAACCCGAGAGGCAGAGGTTGCAATGAGCCAA GATCGTGCCATTGCACTCCAGCCTGGGGGACAGGGCAAGACTGTCTCTCAAAATAAAAAAAAATAATAAAAATAAAAATAAAAGTAATTT CCAAAACCTCATCTCATGGAAAGATCACAGGATGAAGGAAAGCTAGACTCAACTCTGTGAATAGAAGTTGCTATACTGTAAGTAAAGCAA CAATTCAGAATACTGAATGAGTTTAAATTGTTTTATATAGCACCCTTTTGGGCTAGGGTTAATTACTAGATCTGACTTGGATAATTTGAC ACTTTGGGAAATGAACTCTGTTCTTGAGACTTGTTCAGTGTATTTTAAACATCTGAGGAAGAAAACTTAAATATGCACCTATTTATACCT ATTCTTTCTTTAGGTCAACATTTAACACCCACTGCATACATTAATTTGTCCTTGTCTGCTCACTCCAGCAATTTAGACCTTAACAGTCAC AAGAGACGTTCTTCTGTTACAAAGCCTTAGTAAATTAAGGCAGTTTTGATTATATTCTAGGTCCACCTATGTCTGAAGCTAAATTCAGTA TCTAACTGCTAATGAACAAGTTTCCAAAATACTGTAAAAATACAATTAGTCAATTTGAGTAAATGCAAATATGATGAGAAATCAATTTGC TATTTGGCCTGGCAAATGGGAACAGTAAAATTCTGCTTTACTCTTCTCTAGTCTCCTTGCCCCAGCTGCACCCACTACCCCAAAGTTGGC AGTTTTGAGGTATGATTTTCAAGGAATTTTTTTAGTATTAACATCTCCCTCTGAGAACTATGTACCTAAGGTCACGCATACAACTAGTCA ATTCTGTTTTTATTACTCTAACTATGTAGAAACAGTAAGTCACTTAAAACAATCACTTGGCTGGGTTTTTTCCCCTTTGTGCCACATTGA TTCACCCTGACCCAAGAACTCCAGGGAAAATTCTTTAATGTCAACTGGGCAACTCATTAACCTCTCTTTAACATCAAGGGCTTGGGAAAA AAAAAAAAAAGGTTAGCCACAGGAATAACAAAAACCTGGAATTTATCTTTCAGGTTTTGCTTTCTCTTTCTCACTTTGTTTAAAGTATCT CGTACTCACAGTTCACAAATTAACCTTCACTGTCTCTTTCACATTAAGAGCTTATGCTTAAAGCATGCCCCCCTTTTCTAACTTGCTGGT TTACCATAAACTCCCCTAAGTAATAAAATTCCTAACCCAGTACTGAGAGTCCTCCTTCTCTGCCACTTGGGCATTATTTTACTAGTTTTT AAGCCATCATCGCACAAGAATCCAAAAACCCTTAAATTTTTTAACCACTGGCAAATATGTACAGCAAATTAGGTTAAGCATTTAATCTGG CTCATGCTCTATCATACTAAATATTCAGGTTTATCATAAACTCCTTAAAAACCATCAAAGGTCAACCAGAAACTGATAACTCTTGAAAGG AGCAAACAGGTAAGATCTTTGGAGTTTAAGCTTTTCTGAGATGTGTTGTGAAAAATCTAACGTGTTTATCGTATATTCAATGTAACAACC TGGAGAATCACAACTATATTTAAAGAGCCTCTGGAAAATGAGGCCAGTACAGTGTGACTACATGTTTAATTTTCAATGTAATTTATTCCA >In-frame_ENST00000445950_ENST00000257408_TCGA-BH-A1FD-01A_UBE2K_chr4_39776553_+_KLB_chr4_39435830_length(amino acids)=902AA_start in transcript=152_stop in transcript=2860 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGA ICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQS MVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRI LIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQI IRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARM KVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELG DLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWF AEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRL AVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAK SSIQFYNKVISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFSTLVLLLSIAIFQRQKRRKFWKAKNLQHIPLKKGKRV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for UBE2K-KLB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for UBE2K-KLB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for UBE2K-KLB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | KLB | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| Tgene | KLB | C3241937 | Nonalcoholic Steatohepatitis | 1 | CTD_human |
| Tgene | KLB | C3899503 | Congenital hypogonadotropic hypogonadism | 1 | GENOMICS_ENGLAND |
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