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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UBE2K-LIAS (FusionGDB2 ID:95494)

Fusion Gene Summary for UBE2K-LIAS

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2K-LIAS
Fusion gene ID: 95494
HgeneTgene
Gene symbol

UBE2K

LIAS

Gene ID

3093

11019

Gene nameubiquitin conjugating enzyme E2 Klipoic acid synthetase
SynonymsE2-25K|HIP2|HYPG|LIG|UBC1HGCLAS|HUSSY-01|LAS|LIP1|LS|PDHLD
Cytomap

4p14

4p14

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 KE2 ubiquitin-conjugating enzyme KE2(25K)HIP-2huntingtin-interacting protein 2ubiquitin carrier proteinubiquitin conjugating enzyme E2Kubiquitin-conjugating enzyme E2(25K)ubiquitin-conjugating enzyme E2-25 KDAubiqulipoyl synthase, mitochondriallip-synlipoate synthase
Modification date2020031320200313
UniProtAcc.

O43766

Ensembl transtripts involved in fusion geneENST00000261427, ENST00000295963, 
ENST00000438068, ENST00000503368, 
ENST00000445950, 		ENST00000340169, 
ENST00000261434, ENST00000513731, 
ENST00000381846, ENST00000515061, 
Fusion gene scores* DoF score13 X 7 X 10=9102 X 6 X 4=48
# samples 175
** MAII scorelog2(17/910*10)=-2.42033179894836
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UBE2K [Title/Abstract] AND LIAS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUBE2K(39700010)-LIAS(39462410), # samples:3
Anticipated loss of major functional domain due to fusion event.UBE2K-LIAS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2K

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

24882218

HgeneUBE2K

GO:0010994

free ubiquitin chain polymerization

24882218

HgeneUBE2K

GO:0070936

protein K48-linked ubiquitination

20061386


check buttonFusion gene breakpoints across UBE2K (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LIAS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-UU-A93S-01AUBE2Kchr4

39700010

+LIASchr4

39462410

+
ChimerDB4LUSCTCGA-L3-A524-01AUBE2Kchr4

39739131

+LIASchr4

39471637

+
ChimerDB4LUSCTCGA-L3-A524UBE2Kchr4

39739133

+LIASchr4

39471638

+
ChimerDB4BRCATCGA-UU-A93S-01AUBE2Kchr4

39700010

+LIASchr4

39462410

+
ChimerDB4LUSCTCGA-L3-A524UBE2Kchr4

39739131

+LIASchr4

39471637

+
ChimerDB4LUSCTCGA-L3-A524UBE2Kchr4

39739133

+LIASchr4

39471639

+
ChimerDB4OVTCGA-13-0891-01AUBE2Kchr4

39700010

+LIASchr4

39465145

+
ChimerDB4LUSCTCGA-L3-A524-01AUBE2Kchr4

39739133

-LIASchr4

39471639

+
ChimerDB4BRCATCGA-UU-A93S-01AUBE2Kchr4

39700010

-LIASchr4

39462410

+


Top

Fusion Gene ORF analysis for UBE2K-LIAS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261427ENST00000340169UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000261427ENST00000261434UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000261427ENST00000513731UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000261427ENST00000381846UBE2Kchr4

39700010

+LIASchr4

39462410

+
5CDS-3UTRENST00000261427ENST00000515061UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000295963ENST00000340169UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000295963ENST00000261434UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000295963ENST00000513731UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000295963ENST00000381846UBE2Kchr4

39700010

+LIASchr4

39462410

+
5CDS-3UTRENST00000295963ENST00000515061UBE2Kchr4

39700010

+LIASchr4

39462410

+
intron-3CDSENST00000438068ENST00000340169UBE2Kchr4

39700010

+LIASchr4

39462410

+
intron-3CDSENST00000438068ENST00000261434UBE2Kchr4

39700010

+LIASchr4

39462410

+
intron-3CDSENST00000438068ENST00000513731UBE2Kchr4

39700010

+LIASchr4

39462410

+
intron-3CDSENST00000438068ENST00000381846UBE2Kchr4

39700010

+LIASchr4

39462410

+
intron-3UTRENST00000438068ENST00000515061UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000503368ENST00000340169UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000503368ENST00000261434UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000503368ENST00000513731UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000503368ENST00000381846UBE2Kchr4

39700010

+LIASchr4

39462410

+
5CDS-3UTRENST00000503368ENST00000515061UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000445950ENST00000340169UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000445950ENST00000261434UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000445950ENST00000513731UBE2Kchr4

39700010

+LIASchr4

39462410

+
In-frameENST00000445950ENST00000381846UBE2Kchr4

39700010

+LIASchr4

39462410

+
5CDS-3UTRENST00000445950ENST00000515061UBE2Kchr4

39700010

+LIASchr4

39462410

+
Frame-shiftENST00000261427ENST00000340169UBE2Kchr4

39739131

+LIASchr4

39471637

+
Frame-shiftENST00000261427ENST00000261434UBE2Kchr4

39739131

+LIASchr4

39471637

+
Frame-shiftENST00000261427ENST00000513731UBE2Kchr4

39739131

+LIASchr4

39471637

+
Frame-shiftENST00000261427ENST00000381846UBE2Kchr4

39739131

+LIASchr4

39471637

+
5CDS-intronENST00000261427ENST00000515061UBE2Kchr4

39739131

+LIASchr4

39471637

+
Frame-shiftENST00000295963ENST00000340169UBE2Kchr4

39739131

+LIASchr4

39471637

+
Frame-shiftENST00000295963ENST00000261434UBE2Kchr4

39739131

+LIASchr4

39471637

+
Frame-shiftENST00000295963ENST00000513731UBE2Kchr4

39739131

+LIASchr4

39471637

+
Frame-shiftENST00000295963ENST00000381846UBE2Kchr4

39739131

+LIASchr4

39471637

+
5CDS-intronENST00000295963ENST00000515061UBE2Kchr4

39739131

+LIASchr4

39471637

+
3UTR-3CDSENST00000438068ENST00000340169UBE2Kchr4

39739131

+LIASchr4

39471637

+
3UTR-3CDSENST00000438068ENST00000261434UBE2Kchr4

39739131

+LIASchr4

39471637

+
3UTR-3CDSENST00000438068ENST00000513731UBE2Kchr4

39739131

+LIASchr4

39471637

+
3UTR-3CDSENST00000438068ENST00000381846UBE2Kchr4

39739131

+LIASchr4

39471637

+
3UTR-intronENST00000438068ENST00000515061UBE2Kchr4

39739131

+LIASchr4

39471637

+
intron-3CDSENST00000503368ENST00000340169UBE2Kchr4

39739131

+LIASchr4

39471637

+
intron-3CDSENST00000503368ENST00000261434UBE2Kchr4

39739131

+LIASchr4

39471637

+
intron-3CDSENST00000503368ENST00000513731UBE2Kchr4

39739131

+LIASchr4

39471637

+
intron-3CDSENST00000503368ENST00000381846UBE2Kchr4

39739131

+LIASchr4

39471637

+
intron-intronENST00000503368ENST00000515061UBE2Kchr4

39739131

+LIASchr4

39471637

+
Frame-shiftENST00000445950ENST00000340169UBE2Kchr4

39739131

+LIASchr4

39471637

+
Frame-shiftENST00000445950ENST00000261434UBE2Kchr4

39739131

+LIASchr4

39471637

+
Frame-shiftENST00000445950ENST00000513731UBE2Kchr4

39739131

+LIASchr4

39471637

+
Frame-shiftENST00000445950ENST00000381846UBE2Kchr4

39739131

+LIASchr4

39471637

+
5CDS-intronENST00000445950ENST00000515061UBE2Kchr4

39739131

+LIASchr4

39471637

+
Frame-shiftENST00000261427ENST00000340169UBE2Kchr4

39739133

+LIASchr4

39471638

+
Frame-shiftENST00000261427ENST00000261434UBE2Kchr4

39739133

+LIASchr4

39471638

+
Frame-shiftENST00000261427ENST00000513731UBE2Kchr4

39739133

+LIASchr4

39471638

+
Frame-shiftENST00000261427ENST00000381846UBE2Kchr4

39739133

+LIASchr4

39471638

+
5CDS-intronENST00000261427ENST00000515061UBE2Kchr4

39739133

+LIASchr4

39471638

+
Frame-shiftENST00000295963ENST00000340169UBE2Kchr4

39739133

+LIASchr4

39471638

+
Frame-shiftENST00000295963ENST00000261434UBE2Kchr4

39739133

+LIASchr4

39471638

+
Frame-shiftENST00000295963ENST00000513731UBE2Kchr4

39739133

+LIASchr4

39471638

+
Frame-shiftENST00000295963ENST00000381846UBE2Kchr4

39739133

+LIASchr4

39471638

+
5CDS-intronENST00000295963ENST00000515061UBE2Kchr4

39739133

+LIASchr4

39471638

+
3UTR-3CDSENST00000438068ENST00000340169UBE2Kchr4

39739133

+LIASchr4

39471638

+
3UTR-3CDSENST00000438068ENST00000261434UBE2Kchr4

39739133

+LIASchr4

39471638

+
3UTR-3CDSENST00000438068ENST00000513731UBE2Kchr4

39739133

+LIASchr4

39471638

+
3UTR-3CDSENST00000438068ENST00000381846UBE2Kchr4

39739133

+LIASchr4

39471638

+
3UTR-intronENST00000438068ENST00000515061UBE2Kchr4

39739133

+LIASchr4

39471638

+
intron-3CDSENST00000503368ENST00000340169UBE2Kchr4

39739133

+LIASchr4

39471638

+
intron-3CDSENST00000503368ENST00000261434UBE2Kchr4

39739133

+LIASchr4

39471638

+
intron-3CDSENST00000503368ENST00000513731UBE2Kchr4

39739133

+LIASchr4

39471638

+
intron-3CDSENST00000503368ENST00000381846UBE2Kchr4

39739133

+LIASchr4

39471638

+
intron-intronENST00000503368ENST00000515061UBE2Kchr4

39739133

+LIASchr4

39471638

+
Frame-shiftENST00000445950ENST00000340169UBE2Kchr4

39739133

+LIASchr4

39471638

+
Frame-shiftENST00000445950ENST00000261434UBE2Kchr4

39739133

+LIASchr4

39471638

+
Frame-shiftENST00000445950ENST00000513731UBE2Kchr4

39739133

+LIASchr4

39471638

+
Frame-shiftENST00000445950ENST00000381846UBE2Kchr4

39739133

+LIASchr4

39471638

+
5CDS-intronENST00000445950ENST00000515061UBE2Kchr4

39739133

+LIASchr4

39471638

+
Frame-shiftENST00000261427ENST00000340169UBE2Kchr4

39739133

+LIASchr4

39471639

+
Frame-shiftENST00000261427ENST00000261434UBE2Kchr4

39739133

+LIASchr4

39471639

+
Frame-shiftENST00000261427ENST00000513731UBE2Kchr4

39739133

+LIASchr4

39471639

+
Frame-shiftENST00000261427ENST00000381846UBE2Kchr4

39739133

+LIASchr4

39471639

+
5CDS-intronENST00000261427ENST00000515061UBE2Kchr4

39739133

+LIASchr4

39471639

+
Frame-shiftENST00000295963ENST00000340169UBE2Kchr4

39739133

+LIASchr4

39471639

+
Frame-shiftENST00000295963ENST00000261434UBE2Kchr4

39739133

+LIASchr4

39471639

+
Frame-shiftENST00000295963ENST00000513731UBE2Kchr4

39739133

+LIASchr4

39471639

+
Frame-shiftENST00000295963ENST00000381846UBE2Kchr4

39739133

+LIASchr4

39471639

+
5CDS-intronENST00000295963ENST00000515061UBE2Kchr4

39739133

+LIASchr4

39471639

+
3UTR-3CDSENST00000438068ENST00000340169UBE2Kchr4

39739133

+LIASchr4

39471639

+
3UTR-3CDSENST00000438068ENST00000261434UBE2Kchr4

39739133

+LIASchr4

39471639

+
3UTR-3CDSENST00000438068ENST00000513731UBE2Kchr4

39739133

+LIASchr4

39471639

+
3UTR-3CDSENST00000438068ENST00000381846UBE2Kchr4

39739133

+LIASchr4

39471639

+
3UTR-intronENST00000438068ENST00000515061UBE2Kchr4

39739133

+LIASchr4

39471639

+
intron-3CDSENST00000503368ENST00000340169UBE2Kchr4

39739133

+LIASchr4

39471639

+
intron-3CDSENST00000503368ENST00000261434UBE2Kchr4

39739133

+LIASchr4

39471639

+
intron-3CDSENST00000503368ENST00000513731UBE2Kchr4

39739133

+LIASchr4

39471639

+
intron-3CDSENST00000503368ENST00000381846UBE2Kchr4

39739133

+LIASchr4

39471639

+
intron-intronENST00000503368ENST00000515061UBE2Kchr4

39739133

+LIASchr4

39471639

+
Frame-shiftENST00000445950ENST00000340169UBE2Kchr4

39739133

+LIASchr4

39471639

+
Frame-shiftENST00000445950ENST00000261434UBE2Kchr4

39739133

+LIASchr4

39471639

+
Frame-shiftENST00000445950ENST00000513731UBE2Kchr4

39739133

+LIASchr4

39471639

+
Frame-shiftENST00000445950ENST00000381846UBE2Kchr4

39739133

+LIASchr4

39471639

+
5CDS-intronENST00000445950ENST00000515061UBE2Kchr4

39739133

+LIASchr4

39471639

+
In-frameENST00000261427ENST00000340169UBE2Kchr4

39700010

+LIASchr4

39465145

+
In-frameENST00000261427ENST00000261434UBE2Kchr4

39700010

+LIASchr4

39465145

+
5CDS-intronENST00000261427ENST00000513731UBE2Kchr4

39700010

+LIASchr4

39465145

+
5CDS-intronENST00000261427ENST00000381846UBE2Kchr4

39700010

+LIASchr4

39465145

+
5CDS-3UTRENST00000261427ENST00000515061UBE2Kchr4

39700010

+LIASchr4

39465145

+
In-frameENST00000295963ENST00000340169UBE2Kchr4

39700010

+LIASchr4

39465145

+
In-frameENST00000295963ENST00000261434UBE2Kchr4

39700010

+LIASchr4

39465145

+
5CDS-intronENST00000295963ENST00000513731UBE2Kchr4

39700010

+LIASchr4

39465145

+
5CDS-intronENST00000295963ENST00000381846UBE2Kchr4

39700010

+LIASchr4

39465145

+
5CDS-3UTRENST00000295963ENST00000515061UBE2Kchr4

39700010

+LIASchr4

39465145

+
intron-3CDSENST00000438068ENST00000340169UBE2Kchr4

39700010

+LIASchr4

39465145

+
intron-3CDSENST00000438068ENST00000261434UBE2Kchr4

39700010

+LIASchr4

39465145

+
intron-intronENST00000438068ENST00000513731UBE2Kchr4

39700010

+LIASchr4

39465145

+
intron-intronENST00000438068ENST00000381846UBE2Kchr4

39700010

+LIASchr4

39465145

+
intron-3UTRENST00000438068ENST00000515061UBE2Kchr4

39700010

+LIASchr4

39465145

+
In-frameENST00000503368ENST00000340169UBE2Kchr4

39700010

+LIASchr4

39465145

+
In-frameENST00000503368ENST00000261434UBE2Kchr4

39700010

+LIASchr4

39465145

+
5CDS-intronENST00000503368ENST00000513731UBE2Kchr4

39700010

+LIASchr4

39465145

+
5CDS-intronENST00000503368ENST00000381846UBE2Kchr4

39700010

+LIASchr4

39465145

+
5CDS-3UTRENST00000503368ENST00000515061UBE2Kchr4

39700010

+LIASchr4

39465145

+
In-frameENST00000445950ENST00000340169UBE2Kchr4

39700010

+LIASchr4

39465145

+
In-frameENST00000445950ENST00000261434UBE2Kchr4

39700010

+LIASchr4

39465145

+
5CDS-intronENST00000445950ENST00000513731UBE2Kchr4

39700010

+LIASchr4

39465145

+
5CDS-intronENST00000445950ENST00000381846UBE2Kchr4

39700010

+LIASchr4

39465145

+
5CDS-3UTRENST00000445950ENST00000515061UBE2Kchr4

39700010

+LIASchr4

39465145

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261427UBE2Kchr439700010+ENST00000340169LIASchr439462410+17783472841270328
ENST00000261427UBE2Kchr439700010+ENST00000261434LIASchr439462410+19593472841420378
ENST00000261427UBE2Kchr439700010+ENST00000513731LIASchr439462410+10713472841030248
ENST00000261427UBE2Kchr439700010+ENST00000381846LIASchr439462410+17983472841291335
ENST00000295963UBE2Kchr439700010+ENST00000340169LIASchr439462410+17132822191205328
ENST00000295963UBE2Kchr439700010+ENST00000261434LIASchr439462410+18942822191355378
ENST00000295963UBE2Kchr439700010+ENST00000513731LIASchr439462410+1006282219965248
ENST00000295963UBE2Kchr439700010+ENST00000381846LIASchr439462410+17332822191226335
ENST00000503368UBE2Kchr439700010+ENST00000340169LIASchr439462410+16592281651151328
ENST00000503368UBE2Kchr439700010+ENST00000261434LIASchr439462410+18402281651301378
ENST00000503368UBE2Kchr439700010+ENST00000513731LIASchr439462410+952228165911248
ENST00000503368UBE2Kchr439700010+ENST00000381846LIASchr439462410+16792281651172335
ENST00000445950UBE2Kchr439700010+ENST00000340169LIASchr439462410+16462151521138328
ENST00000445950UBE2Kchr439700010+ENST00000261434LIASchr439462410+18272151521288378
ENST00000445950UBE2Kchr439700010+ENST00000513731LIASchr439462410+939215152898248
ENST00000445950UBE2Kchr439700010+ENST00000381846LIASchr439462410+16662151521159335
ENST00000261427UBE2Kchr439700010+ENST00000340169LIASchr439465145+15113472841003239
ENST00000261427UBE2Kchr439700010+ENST00000261434LIASchr439465145+16923472841153289
ENST00000295963UBE2Kchr439700010+ENST00000340169LIASchr439465145+1446282219938239
ENST00000295963UBE2Kchr439700010+ENST00000261434LIASchr439465145+16272822191088289
ENST00000503368UBE2Kchr439700010+ENST00000340169LIASchr439465145+1392228165884239
ENST00000503368UBE2Kchr439700010+ENST00000261434LIASchr439465145+15732281651034289
ENST00000445950UBE2Kchr439700010+ENST00000340169LIASchr439465145+1379215152871239
ENST00000445950UBE2Kchr439700010+ENST00000261434LIASchr439465145+15602151521021289

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261427ENST00000340169UBE2Kchr439700010+LIASchr439462410+0.0009767430.9990232
ENST00000261427ENST00000261434UBE2Kchr439700010+LIASchr439462410+0.0007850860.9992149
ENST00000261427ENST00000513731UBE2Kchr439700010+LIASchr439462410+0.0018512720.9981488
ENST00000261427ENST00000381846UBE2Kchr439700010+LIASchr439462410+0.0011238490.99887615
ENST00000295963ENST00000340169UBE2Kchr439700010+LIASchr439462410+0.0008579110.99914205
ENST00000295963ENST00000261434UBE2Kchr439700010+LIASchr439462410+0.0006762020.99932384
ENST00000295963ENST00000513731UBE2Kchr439700010+LIASchr439462410+0.0018642390.9981357
ENST00000295963ENST00000381846UBE2Kchr439700010+LIASchr439462410+0.001009240.9989907
ENST00000503368ENST00000340169UBE2Kchr439700010+LIASchr439462410+0.0009389250.99906105
ENST00000503368ENST00000261434UBE2Kchr439700010+LIASchr439462410+0.0007011210.9992988
ENST00000503368ENST00000513731UBE2Kchr439700010+LIASchr439462410+0.001758680.9982413
ENST00000503368ENST00000381846UBE2Kchr439700010+LIASchr439462410+0.0009868820.99901307
ENST00000445950ENST00000340169UBE2Kchr439700010+LIASchr439462410+0.0009060610.999094
ENST00000445950ENST00000261434UBE2Kchr439700010+LIASchr439462410+0.0006959570.99930406
ENST00000445950ENST00000513731UBE2Kchr439700010+LIASchr439462410+0.0017919860.99820805
ENST00000445950ENST00000381846UBE2Kchr439700010+LIASchr439462410+0.0009881460.9990119
ENST00000261427ENST00000340169UBE2Kchr439700010+LIASchr439465145+0.0020540920.99794596
ENST00000261427ENST00000261434UBE2Kchr439700010+LIASchr439465145+0.0008980560.999102
ENST00000295963ENST00000340169UBE2Kchr439700010+LIASchr439465145+0.0021433780.99785656
ENST00000295963ENST00000261434UBE2Kchr439700010+LIASchr439465145+0.0009056680.99909437
ENST00000503368ENST00000340169UBE2Kchr439700010+LIASchr439465145+0.0018186760.99818134
ENST00000503368ENST00000261434UBE2Kchr439700010+LIASchr439465145+0.0008295370.99917054
ENST00000445950ENST00000340169UBE2Kchr439700010+LIASchr439465145+0.0017881240.99821186
ENST00000445950ENST00000261434UBE2Kchr439700010+LIASchr439465145+0.0008304510.9991696

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Fusion Genomic Features for UBE2K-LIAS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
UBE2Kchr439700010+LIASchr439462409+1.84E-091
UBE2Kchr439739133+LIASchr439471638+2.95E-111
UBE2Kchr439739133+LIASchr439471638+2.95E-111
UBE2Kchr439700010+LIASchr439465144+7.73E-121
UBE2Kchr439700010+LIASchr439462409+1.84E-091
UBE2Kchr439739133+LIASchr439471638+2.95E-111
UBE2Kchr439739133+LIASchr439471638+2.95E-111
UBE2Kchr439700010+LIASchr439465144+7.73E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBE2K-LIAS


check button Go to

FGviewer for the breakpoints of chr4:39700010-chr4:39462410

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LIAS

O43766

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000255|HAMAP-Rule:MF_03123}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLIASchr4:39700010chr4:39462410ENST00000261434011122_34115.0373.0DomainRadical SAM core
TgeneLIASchr4:39700010chr4:39462410ENST00000340169010122_34115.0323.0DomainRadical SAM core
TgeneLIASchr4:39700010chr4:39465145ENST00000261434211122_341104.0373.0DomainRadical SAM core
TgeneLIASchr4:39700010chr4:39465145ENST00000340169210122_341104.0323.0DomainRadical SAM core

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBE2Kchr4:39700010chr4:39462410ENST00000261427+17160_20021.0201.0DomainUBA
HgeneUBE2Kchr4:39700010chr4:39462410ENST00000261427+174_15421.0201.0DomainUBC core
HgeneUBE2Kchr4:39700010chr4:39462410ENST00000445950+16160_20021.0158.0DomainUBA
HgeneUBE2Kchr4:39700010chr4:39462410ENST00000445950+164_15421.0158.0DomainUBC core
HgeneUBE2Kchr4:39700010chr4:39462410ENST00000503368+15160_20021.0150.0DomainUBA
HgeneUBE2Kchr4:39700010chr4:39462410ENST00000503368+154_15421.0150.0DomainUBC core
HgeneUBE2Kchr4:39700010chr4:39465145ENST00000261427+17160_20021.0201.0DomainUBA
HgeneUBE2Kchr4:39700010chr4:39465145ENST00000261427+174_15421.0201.0DomainUBC core
HgeneUBE2Kchr4:39700010chr4:39465145ENST00000445950+16160_20021.0158.0DomainUBA
HgeneUBE2Kchr4:39700010chr4:39465145ENST00000445950+164_15421.0158.0DomainUBC core
HgeneUBE2Kchr4:39700010chr4:39465145ENST00000503368+15160_20021.0150.0DomainUBA
HgeneUBE2Kchr4:39700010chr4:39465145ENST00000503368+154_15421.0150.0DomainUBC core


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Fusion Gene Sequence for UBE2K-LIAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000261427_ENST00000340169_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1778nt_BP=347nt
ACGCGAGCTCGTGGCTCGGGCGTATGGGGGCTCCAACGGGAGCGGCTGCGCCGCCCGGCCGGGTCAACGTCGTGCGCATGCGCCGACCCG
GCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGG
TCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAG
CTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATTTGGGAGAT
ATTTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATAAAAAAAAGGAACTCCTACAGAATGGACCAGACCTTCAAGATTTTGTAT
CTGGTGATCTTGCAGACAGGAGCACCTGGGATGAATATAAAGGAAACCTAAAACGCCAGAAAGGAGAAAGGTTAAGACTACCTCCATGGC
TAAAGACAGAGATTCCCATGGGGAAAAATTACAATAAACTGAAAAATACTTTGCGGAATTTAAATCTCCATACAGTATGTGAGGAAGCTC
GATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAG
GTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAAT
GGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATT
TAAAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGTCAG
GATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTAC
GTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTAT
ATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTGA
ATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAAT
TTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAAT
AGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCC
TGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAG
GCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGC

>In-frame_ENST00000261427_ENST00000340169_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=328AA_start in transcript=284_stop in transcript=1270
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEI
PMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDY
VVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKH

--------------------------------------------------------------
>In-frame_ENST00000261427_ENST00000261434_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1959nt_BP=347nt
ACGCGAGCTCGTGGCTCGGGCGTATGGGGGCTCCAACGGGAGCGGCTGCGCCGCCCGGCCGGGTCAACGTCGTGCGCATGCGCCGACCCG
GCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGG
TCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAG
CTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATTTGGGAGAT
ATTTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATAAAAAAAAGGAACTCCTACAGAATGGACCAGACCTTCAAGATTTTGTAT
CTGGTGATCTTGCAGACAGGAGCACCTGGGATGAATATAAAGGAAACCTAAAACGCCAGAAAGGAGAAAGGTTAAGACTACCTCCATGGC
TAAAGACAGAGATTCCCATGGGGAAAAATTACAATAAACTGAAAAATACTTTGCGGAATTTAAATCTCCATACAGTATGTGAGGAAGCTC
GATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAG
GTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAAT
GGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATT
TAAAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGTCAG
GATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTAC
GTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTAT
ATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTTG
AAGAATATATTACTCCTGAAAAATTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGATTTCATTATACTGCAAGTGGCCCTTTGGTGC
GTTCTTCATATAAAGCAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCTTCA
AGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTCTTT
GCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACCTGA
GGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGTGCC
TGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCC
CTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAATAAAAAGGAAAAAAAAGTCAATAAACTGTACAAATTTAATTACAGTAA

>In-frame_ENST00000261427_ENST00000261434_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=378AA_start in transcript=284_stop in transcript=1420
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEI
PMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDY
VVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKH
AKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYK

--------------------------------------------------------------
>In-frame_ENST00000261427_ENST00000513731_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1071nt_BP=347nt
ACGCGAGCTCGTGGCTCGGGCGTATGGGGGCTCCAACGGGAGCGGCTGCGCCGCCCGGCCGGGTCAACGTCGTGCGCATGCGCCGACCCG
GCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGG
TCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAG
CTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATTTGGGAGAT
ATTTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATAAAAAAAAGGAACTCCTACAGAATGGACCAGACCTTCAAGATTTTGTAT
CTGGTGATCTTGCAGACAGGAGCACCTGGGATGAATATAAAGGAAACCTAAAACGCCAGAAAGGAGAAAGGAATCCAAAAATCCTTGTGG
AGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAA
CAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGC
CTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAG
ATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTTGAAGAATATATTACTCCTGAAAAATTCAAAT
ACTGGGAAAAAGTAGGAAATGAACTTGGATTTCATTATACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTCC

>In-frame_ENST00000261427_ENST00000513731_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=248AA_start in transcript=284_stop in transcript=1030
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERNPKILVECLTP
DFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCL

--------------------------------------------------------------
>In-frame_ENST00000261427_ENST00000381846_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1798nt_BP=347nt
ACGCGAGCTCGTGGCTCGGGCGTATGGGGGCTCCAACGGGAGCGGCTGCGCCGCCCGGCCGGGTCAACGTCGTGCGCATGCGCCGACCCG
GCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGG
TCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAG
CTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATTTGGGAGAT
ATTTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATAAAAAAAAGGAACTCCTACAGAATGGACCAGACCTTCAAGATTTTGTAT
CTGGTGATCTTGCAGACAGGAGCACCTGGGATGAATATAAAGGAAACCTAAAACGCCAGAAAGGAGAAAGGTTAAGACTACCTCCATGGC
TAAAGACAGAGATTCCCATGGGGAAAAATTACAATAAACTGAAAAATACTTTGCGGAATTTAAATCTCCATACAGTATGTGAGGAAGCTC
GATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAG
GTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAAT
GGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATT
TAAAGGAAAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTA
TTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACT
GCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTTGAAGAATATATTACTCCTGAAAAATTCAAATACTGGGAAA
AAGTAGGAAATGAACTTGGATTTCATTATACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTCCTGAAAAATC
TAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAA
CAGAGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCT
CACGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAA
TCCTGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATC
ACTTGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAAT

>In-frame_ENST00000261427_ENST00000381846_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=335AA_start in transcript=284_stop in transcript=1291
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEI
PMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDY
VVLTSVDRDDMPDGGAEHIAKTVSYLKESKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLG

--------------------------------------------------------------
>In-frame_ENST00000295963_ENST00000340169_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1713nt_BP=282nt
AACGTCGTGCGCATGCGCCGACCCGGCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGG
TAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGT
GGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTG
AAGAGCGAGGAGGTATTTGGGAGATATTTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATAAAAAAAAGGAACTCCTACAGAAT
GGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGGGATGAATATAAAGGAAACCTAAAACGCCAGAAAGGA
GAAAGGTTAAGACTACCTCCATGGCTAAAGACAGAGATTCCCATGGGGAAAAATTACAATAAACTGAAAAATACTTTGCGGAATTTAAAT
CTCCATACAGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATGCCACCGCCACAGCCACGATCATG
TTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTAC
AATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATGATATGCCTGATGGGGGAGCTGAA
CACATTGCAAAGACCGTATCATATTTAAAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAA
GCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCT
CGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGT
TTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAG
CCAACAAGGCGTCACCTTAAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCT
TCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTC
TTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACC
TGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGT
GCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATT
GCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAATAAAAAGGAAAAAAAAGTCAATAAACTGTACAAATTTAATTACAG

>In-frame_ENST00000295963_ENST00000340169_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=328AA_start in transcript=219_stop in transcript=1205
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEI
PMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDY
VVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKH

--------------------------------------------------------------
>In-frame_ENST00000295963_ENST00000261434_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1894nt_BP=282nt
AACGTCGTGCGCATGCGCCGACCCGGCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGG
TAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGT
GGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTG
AAGAGCGAGGAGGTATTTGGGAGATATTTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATAAAAAAAAGGAACTCCTACAGAAT
GGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGGGATGAATATAAAGGAAACCTAAAACGCCAGAAAGGA
GAAAGGTTAAGACTACCTCCATGGCTAAAGACAGAGATTCCCATGGGGAAAAATTACAATAAACTGAAAAATACTTTGCGGAATTTAAAT
CTCCATACAGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATGCCACCGCCACAGCCACGATCATG
TTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTAC
AATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATGATATGCCTGATGGGGGAGCTGAA
CACATTGCAAAGACCGTATCATATTTAAAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAA
GCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCT
CGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGT
TTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAG
CCAACAAGGCGTCACCTTAAGGTTGAAGAATATATTACTCCTGAAAAATTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGATTTCAT
TATACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGAC
CTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGAC
TGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGG
AGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACAAAAA
TTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTGC
AGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAATAAAAAGGAAAAAAAAGTCAATA
AACTGTACAAATTTAATTACAGTAATTCATTTGGCTTTTAGTGTATCTTCTTTGTCCCAATTAAACAGTTGCTTGCTGTGATGTAATCTT

>In-frame_ENST00000295963_ENST00000261434_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=378AA_start in transcript=219_stop in transcript=1355
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEI
PMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDY
VVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKH
AKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYK

--------------------------------------------------------------
>In-frame_ENST00000295963_ENST00000513731_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1006nt_BP=282nt
AACGTCGTGCGCATGCGCCGACCCGGCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGG
TAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGT
GGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTG
AAGAGCGAGGAGGTATTTGGGAGATATTTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATAAAAAAAAGGAACTCCTACAGAAT
GGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGGGATGAATATAAAGGAAACCTAAAACGCCAGAAAGGA
GAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGTCAGGATTA
GATGTGTATGCACATAATGTAGAAACAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTA
CTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCA
ACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTTGAAGAA
TATATTACTCCTGAAAAATTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGATTTCATTATACTGCAAGTGGCCCTTTGGTGCGTTCT
TCATATAAAGCAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCTTCAAGATC

>In-frame_ENST00000295963_ENST00000513731_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=248AA_start in transcript=219_stop in transcript=965
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERNPKILVECLTP
DFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCL

--------------------------------------------------------------
>In-frame_ENST00000295963_ENST00000381846_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1733nt_BP=282nt
AACGTCGTGCGCATGCGCCGACCCGGCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGG
TAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGT
GGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTG
AAGAGCGAGGAGGTATTTGGGAGATATTTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATAAAAAAAAGGAACTCCTACAGAAT
GGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGGGATGAATATAAAGGAAACCTAAAACGCCAGAAAGGA
GAAAGGTTAAGACTACCTCCATGGCTAAAGACAGAGATTCCCATGGGGAAAAATTACAATAAACTGAAAAATACTTTGCGGAATTTAAAT
CTCCATACAGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATGCCACCGCCACAGCCACGATCATG
TTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTAC
AATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATGATATGCCTGATGGGGGAGCTGAA
CACATTGCAAAGACCGTATCATATTTAAAGGAAAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACAT
GCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAA
GCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTTGAAGAATATATTACT
CCTGAAAAATTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGATTTCATTATACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAA
GCAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATT
TTTAAAATTTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAA
ATGTCAATAGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGA
GACCAGCCTGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTA
CTCGGGAGGCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTG
ACAAGAGCAAAACTCCATCTCAAATAAATAAAAAGGAAAAAAAAGTCAATAAACTGTACAAATTTAATTACAGTAATTCATTTGGCTTTT

>In-frame_ENST00000295963_ENST00000381846_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=335AA_start in transcript=219_stop in transcript=1226
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEI
PMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDY
VVLTSVDRDDMPDGGAEHIAKTVSYLKESKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLG

--------------------------------------------------------------
>In-frame_ENST00000503368_ENST00000340169_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1659nt_BP=228nt
GATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGA
GGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCG
GTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATTTGGGAGATATTTTTGCAGCCCAGTCAGACCGTTAAGC
TCCTTGCCAGATAAAAAAAAGGAACTCCTACAGAATGGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGG
GATGAATATAAAGGAAACCTAAAACGCCAGAAAGGAGAAAGGTTAAGACTACCTCCATGGCTAAAGACAGAGATTCCCATGGGGAAAAAT
TACAATAAACTGAAAAATACTTTGCGGAATTTAAATCTCCATACAGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGA
GGTGGAGAATATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCA
AGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCT
GTGGATCGAGATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATTTAAAGGAAAGGAATCCAAAAATCCTTGTG
GAGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAA
ACAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAG
CCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCA
GATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAA
GAAAAACAAAAGACCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAGAGGTGGTGC
CAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCACGCCTGTAAT
CCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTGTCTCCAC
TAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACTTGAACCTGG
GAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAATAAAAAGGA

>In-frame_ENST00000503368_ENST00000340169_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=328AA_start in transcript=165_stop in transcript=1151
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEI
PMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDY
VVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKH

--------------------------------------------------------------
>In-frame_ENST00000503368_ENST00000261434_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1840nt_BP=228nt
GATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGA
GGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCG
GTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATTTGGGAGATATTTTTGCAGCCCAGTCAGACCGTTAAGC
TCCTTGCCAGATAAAAAAAAGGAACTCCTACAGAATGGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGG
GATGAATATAAAGGAAACCTAAAACGCCAGAAAGGAGAAAGGTTAAGACTACCTCCATGGCTAAAGACAGAGATTCCCATGGGGAAAAAT
TACAATAAACTGAAAAATACTTTGCGGAATTTAAATCTCCATACAGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGA
GGTGGAGAATATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCA
AGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCT
GTGGATCGAGATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATTTAAAGGAAAGGAATCCAAAAATCCTTGTG
GAGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAA
ACAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAG
CCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCA
GATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTTGAAGAATATATTACTCCTGAAAAATTCAAA
TACTGGGAAAAAGTAGGAAATGAACTTGGATTTCATTATACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTC
CTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAATTTGATTC
CAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGG
CATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAA
CATGGTGAAATCCTGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGG
CAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTC
CATCTCAAATAAATAAAAAGGAAAAAAAAGTCAATAAACTGTACAAATTTAATTACAGTAATTCATTTGGCTTTTAGTGTATCTTCTTTG

>In-frame_ENST00000503368_ENST00000261434_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=378AA_start in transcript=165_stop in transcript=1301
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEI
PMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDY
VVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKH
AKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYK

--------------------------------------------------------------
>In-frame_ENST00000503368_ENST00000513731_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=952nt_BP=228nt
GATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGA
GGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCG
GTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATTTGGGAGATATTTTTGCAGCCCAGTCAGACCGTTAAGC
TCCTTGCCAGATAAAAAAAAGGAACTCCTACAGAATGGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGG
GATGAATATAAAGGAAACCTAAAACGCCAGAAAGGAGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGAT
CTCAAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGGAATTACAGAGTAAGGTTCGT
GATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATG
TTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATAT
ATGCAGCCAACAAGGCGTCACCTTAAGGTTGAAGAATATATTACTCCTGAAAAATTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGA
TTTCATTATACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACA

>In-frame_ENST00000503368_ENST00000513731_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=248AA_start in transcript=165_stop in transcript=911
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERNPKILVECLTP
DFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCL

--------------------------------------------------------------
>In-frame_ENST00000503368_ENST00000381846_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1679nt_BP=228nt
GATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGA
GGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCG
GTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATTTGGGAGATATTTTTGCAGCCCAGTCAGACCGTTAAGC
TCCTTGCCAGATAAAAAAAAGGAACTCCTACAGAATGGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGG
GATGAATATAAAGGAAACCTAAAACGCCAGAAAGGAGAAAGGTTAAGACTACCTCCATGGCTAAAGACAGAGATTCCCATGGGGAAAAAT
TACAATAAACTGAAAAATACTTTGCGGAATTTAAATCTCCATACAGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGA
GGTGGAGAATATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCA
AGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCT
GTGGATCGAGATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATTTAAAGGAAAGTAAGGTTCGTGATCCTCGG
GCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTA
GGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCA
ACAAGGCGTCACCTTAAGGTTGAAGAATATATTACTCCTGAAAAATTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGATTTCATTAT
ACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTC
TAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGACTGC
AGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGAGG
CCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACAAAAATTA
GTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTGCAGT
GAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAATAAAAAGGAAAAAAAAGTCAATAAAC

>In-frame_ENST00000503368_ENST00000381846_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=335AA_start in transcript=165_stop in transcript=1172
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEI
PMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDY
VVLTSVDRDDMPDGGAEHIAKTVSYLKESKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLG

--------------------------------------------------------------
>In-frame_ENST00000445950_ENST00000340169_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1646nt_BP=215nt
GGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCG
GCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCA
AGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATTTGGGAGATATTTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATA
AAAAAAAGGAACTCCTACAGAATGGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGGGATGAATATAAAG
GAAACCTAAAACGCCAGAAAGGAGAAAGGTTAAGACTACCTCCATGGCTAAAGACAGAGATTCCCATGGGGAAAAATTACAATAAACTGA
AAAATACTTTGCGGAATTTAAATCTCCATACAGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATG
CCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTC
CACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATG
ATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATTTAAAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTC
CTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGGAAT
TACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTT
CTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCT
TGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGA
CCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGA
CTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAG
GAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACAAAA
ATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTG
CAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAATAAAAAGGAAAAAAAAGTCAAT

>In-frame_ENST00000445950_ENST00000340169_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=328AA_start in transcript=152_stop in transcript=1138
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEI
PMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDY
VVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKH

--------------------------------------------------------------
>In-frame_ENST00000445950_ENST00000261434_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1827nt_BP=215nt
GGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCG
GCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCA
AGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATTTGGGAGATATTTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATA
AAAAAAAGGAACTCCTACAGAATGGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGGGATGAATATAAAG
GAAACCTAAAACGCCAGAAAGGAGAAAGGTTAAGACTACCTCCATGGCTAAAGACAGAGATTCCCATGGGGAAAAATTACAATAAACTGA
AAAATACTTTGCGGAATTTAAATCTCCATACAGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATG
CCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTC
CACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATG
ATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATTTAAAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTC
CTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGGAAT
TACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTT
CTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCT
TGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTTGAAGAATATATTACTCCTGAAAAATTCAAATACTGGGAAAAAG
TAGGAAATGAACTTGGATTTCATTATACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTCCTGAAAAATCTAG
TGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAG
AGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCAC
GCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCC
TGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACT
TGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAA
TAAAAAGGAAAAAAAAGTCAATAAACTGTACAAATTTAATTACAGTAATTCATTTGGCTTTTAGTGTATCTTCTTTGTCCCAATTAAACA

>In-frame_ENST00000445950_ENST00000261434_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=378AA_start in transcript=152_stop in transcript=1288
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEI
PMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDY
VVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKH
AKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYK

--------------------------------------------------------------
>In-frame_ENST00000445950_ENST00000513731_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=939nt_BP=215nt
GGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCG
GCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCA
AGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATTTGGGAGATATTTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATA
AAAAAAAGGAACTCCTACAGAATGGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGGGATGAATATAAAG
GAAACCTAAAACGCCAGAAAGGAGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAAGCAATAG
AAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCA
ATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCG
AGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAA
GGCGTCACCTTAAGGTTGAAGAATATATTACTCCTGAAAAATTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGATTTCATTATACTG
CAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAAA

>In-frame_ENST00000445950_ENST00000513731_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=248AA_start in transcript=152_stop in transcript=898
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERNPKILVECLTP
DFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCL

--------------------------------------------------------------
>In-frame_ENST00000445950_ENST00000381846_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(transcript)=1666nt_BP=215nt
GGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCG
GCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCA
AGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATTTGGGAGATATTTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATA
AAAAAAAGGAACTCCTACAGAATGGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGGGATGAATATAAAG
GAAACCTAAAACGCCAGAAAGGAGAAAGGTTAAGACTACCTCCATGGCTAAAGACAGAGATTCCCATGGGGAAAAATTACAATAAACTGA
AAAATACTTTGCGGAATTTAAATCTCCATACAGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATG
CCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTC
CACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATG
ATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATTTAAAGGAAAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATC
AGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATG
AGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACC
TTAAGGTTGAAGAATATATTACTCCTGAAAAATTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGATTTCATTATACTGCAAGTGGCC
CTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACA
AGACCTTCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCC
CACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGG
ATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTA
GTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGC
TCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAATAAAAAGGAAAAAAAAGTCAATAAACTGTACAAATTTAA

>In-frame_ENST00000445950_ENST00000381846_TCGA-UU-A93S-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39462410_length(amino acids)=335AA_start in transcript=152_stop in transcript=1159
MANIAVQRIKREFKEVLKSEEVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEI
PMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDY
VVLTSVDRDDMPDGGAEHIAKTVSYLKESKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLG

--------------------------------------------------------------
>In-frame_ENST00000261427_ENST00000340169_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(transcript)=1511nt_BP=347nt
ACGCGAGCTCGTGGCTCGGGCGTATGGGGGCTCCAACGGGAGCGGCTGCGCCGCCCGGCCGGGTCAACGTCGTGCGCATGCGCCGACCCG
GCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGG
TCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAG
CTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATGTGAGGAAG
CTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAA
GAGGTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAG
AATGGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCAT
ATTTAAAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGT
CAGGATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCC
TACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAG
TATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGG
TGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAA
AATTTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTC
AATAGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCA
GCCTGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGG
GAGGCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAG

>In-frame_ENST00000261427_ENST00000340169_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(amino acids)=239AA_start in transcript=284_stop in transcript=1003
MANIAVQRIKREFKEVLKSEEVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLD
YVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLK

--------------------------------------------------------------
>In-frame_ENST00000261427_ENST00000261434_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(transcript)=1692nt_BP=347nt
ACGCGAGCTCGTGGCTCGGGCGTATGGGGGCTCCAACGGGAGCGGCTGCGCCGCCCGGCCGGGTCAACGTCGTGCGCATGCGCCGACCCG
GCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGG
TCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAG
CTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATGTGAGGAAG
CTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAA
GAGGTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAG
AATGGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCAT
ATTTAAAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGT
CAGGATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCC
TACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAG
TATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGG
TTGAAGAATATATTACTCCTGAAAAATTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGATTTCATTATACTGCAAGTGGCCCTTTGG
TGCGTTCTTCATATAAAGCAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCT
TCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTC
TTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACC
TGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGT
GCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATT
GCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAATAAAAAGGAAAAAAAAGTCAATAAACTGTACAAATTTAATTACAG

>In-frame_ENST00000261427_ENST00000261434_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(amino acids)=289AA_start in transcript=284_stop in transcript=1153
MANIAVQRIKREFKEVLKSEEVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLD
YVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLK
HAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSY

--------------------------------------------------------------
>In-frame_ENST00000295963_ENST00000340169_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(transcript)=1446nt_BP=282nt
AACGTCGTGCGCATGCGCCGACCCGGCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGG
TAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGT
GGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTG
AAGAGCGAGGAGGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATGCCACCGCCACAGCCACGATC
ATGTTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCC
TACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATGATATGCCTGATGGGGGAGCT
GAACACATTGCAAAGACCGTATCATATTTAAAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTC
AAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGGAATTACAGAGTAAGGTTCGTGAT
CCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTG
GGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATG
CAGCCAACAAGGCGTCACCTTAAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGA
CCTTCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCAC
CTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATC
ACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTG
GGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCC
ATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAATAAAAAGGAAAAAAAAGTCAATAAACTGTACAAATTTAATTA

>In-frame_ENST00000295963_ENST00000340169_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(amino acids)=239AA_start in transcript=219_stop in transcript=938
MANIAVQRIKREFKEVLKSEEVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLD
YVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLK

--------------------------------------------------------------
>In-frame_ENST00000295963_ENST00000261434_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(transcript)=1627nt_BP=282nt
AACGTCGTGCGCATGCGCCGACCCGGCGCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGG
TAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGT
GGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTG
AAGAGCGAGGAGGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAATATGCCACCGCCACAGCCACGATC
ATGTTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCC
TACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAGATGATATGCCTGATGGGGGAGCT
GAACACATTGCAAAGACCGTATCATATTTAAAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTC
AAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGGAATTACAGAGTAAGGTTCGTGAT
CCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTG
GGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACTGCTTGACTTTAGGACAATATATG
CAGCCAACAAGGCGTCACCTTAAGGTTGAAGAATATATTACTCCTGAAAAATTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGATTT
CATTATACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAA
GACCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTG
GACTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTT
AGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACAA
AAATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGT
TGCAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAATAAAAAGGAAAAAAAAGTCA
ATAAACTGTACAAATTTAATTACAGTAATTCATTTGGCTTTTAGTGTATCTTCTTTGTCCCAATTAAACAGTTGCTTGCTGTGATGTAAT

>In-frame_ENST00000295963_ENST00000261434_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(amino acids)=289AA_start in transcript=219_stop in transcript=1088
MANIAVQRIKREFKEVLKSEEVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLD
YVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLK
HAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSY

--------------------------------------------------------------
>In-frame_ENST00000503368_ENST00000340169_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(transcript)=1392nt_BP=228nt
GATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGA
GGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCG
GTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGG
GGAGGTGGAGAATATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACT
GCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACA
TCTGTGGATCGAGATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATTTAAAGGAAAGGAATCCAAAAATCCTT
GTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTA
GAAACAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTT
CAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAG
GCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTGAATTTTTCCTGAAAAATCTAGTGGCTA
AAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAGAGGTGG
TGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCACGCCTGT
AATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTGTCTC
CACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACTTGAACC
TGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAATAAAAA

>In-frame_ENST00000503368_ENST00000340169_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(amino acids)=239AA_start in transcript=165_stop in transcript=884
MANIAVQRIKREFKEVLKSEEVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLD
YVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLK

--------------------------------------------------------------
>In-frame_ENST00000503368_ENST00000261434_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(transcript)=1573nt_BP=228nt
GATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGA
GGAAGAGGTGGCGGCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCG
GTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGG
GGAGGTGGAGAATATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACT
GCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACA
TCTGTGGATCGAGATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATTTAAAGGAAAGGAATCCAAAAATCCTT
GTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTA
GAAACAGTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTT
CAGCCTGATGTTATTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAG
GCAGATGTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTTGAAGAATATATTACTCCTGAAAAATTC
AAATACTGGGAAAAAGTAGGAAATGAACTTGGATTTCATTATACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTT
TTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAATTTGA
TTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCC
AGGCATAGTGGCTCACGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGC
CAACATGGTGAAATCCTGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTA
AGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAA
CTCCATCTCAAATAAATAAAAAGGAAAAAAAAGTCAATAAACTGTACAAATTTAATTACAGTAATTCATTTGGCTTTTAGTGTATCTTCT

>In-frame_ENST00000503368_ENST00000261434_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(amino acids)=289AA_start in transcript=165_stop in transcript=1034
MANIAVQRIKREFKEVLKSEEVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLD
YVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLK
HAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSY

--------------------------------------------------------------
>In-frame_ENST00000445950_ENST00000340169_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(transcript)=1379nt_BP=215nt
GGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCG
GCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCA
AGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAAT
ATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTC
CTCCACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAG
ATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATTTAAAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTA
CTCCTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGG
AATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTA
TTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACT
GCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTGAATTTTTCCTGAAAAATCTAGTGGCTAAAAGAAAAACAAA
AGACCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAACAGAGGTGGTGCCAGAATGCCT
GGACTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCTCACGCCTGTAATCCCAGCACTT
TAGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAATCCTGTCTCCACTAAAAACACA
AAAATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATCACTTGAACCTGGGAGGGGGAGG
TTGCAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAATAAATAAAAAGGAAAAAAAAGTC

>In-frame_ENST00000445950_ENST00000340169_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(amino acids)=239AA_start in transcript=152_stop in transcript=871
MANIAVQRIKREFKEVLKSEEVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLD
YVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLK

--------------------------------------------------------------
>In-frame_ENST00000445950_ENST00000261434_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(transcript)=1560nt_BP=215nt
GGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGGGAGGAGGCGGTGGAGGAAGAGGTGGCG
GCGGTGGCGGTGGTCGTAGCGGTGGCGGAGGAGGCGGGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCA
AGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGTGGAGAAT
ATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAGGTTGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTC
CTCCACTGGATGCCAGTGAGCCCTACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACATCTGTGGATCGAG
ATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATTTAAAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTA
CTCCTGATTTTCGAGGTGATCTCAAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAACAGTCCCGG
AATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGTGTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTA
TTTCTAAAACATCTATAATGTTGGGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGATGTAGACT
GCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTTGAAGAATATATTACTCCTGAAAAATTCAAATACTGGGAAA
AAGTAGGAAATGAACTTGGATTTCATTATACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTCCTGAAAAATC
TAGTGGCTAAAAGAAAAACAAAAGACCTCTAAAACTTCAACAAGACCTTCAAGATCACAGAAATTTTTAAAATTTGATTCCAGTTAATAA
CAGAGGTGGTGCCAGAATGCCTGGACTGCAGTGGATGTGCCCCACCTCTTTGCTTAAAAAAAAAAATGTCAATAGCCAGGCATAGTGGCT
CACGCCTGTAATCCCAGCACTTTAGGAGGCCAAGGCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAA
TCCTGTCTCCACTAAAAACACAAAAATTAGTCAGGCGTGGTAGTGGGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGAGAATC
ACTTGAACCTGGGAGGGGGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCCCTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAAT
AAATAAAAAGGAAAAAAAAGTCAATAAACTGTACAAATTTAATTACAGTAATTCATTTGGCTTTTAGTGTATCTTCTTTGTCCCAATTAA

>In-frame_ENST00000445950_ENST00000261434_TCGA-13-0891-01A_UBE2K_chr4_39700010_+_LIAS_chr4_39465145_length(amino acids)=289AA_start in transcript=152_stop in transcript=1021
MANIAVQRIKREFKEVLKSEEVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLD
YVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLK
HAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for UBE2K-LIAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UBE2K-LIAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneLIASO43766DB00166Lipoic acidSmall moleculeApproved|Investigational|Nutraceutical
TgeneLIASO43766DB00166Lipoic acidSmall moleculeApproved|Investigational|Nutraceutical
TgeneLIASO43766DB00166Lipoic acidSmall moleculeApproved|Investigational|Nutraceutical

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Related Diseases for UBE2K-LIAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLIASC3280887HYPERGLYCINEMIA, LACTIC ACIDOSIS, AND SEIZURES5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT