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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UBE4B-PEX14 (FusionGDB2 ID:95671)

Fusion Gene Summary for UBE4B-PEX14

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE4B-PEX14
Fusion gene ID: 95671
HgeneTgene
Gene symbol

UBE4B

PEX14

Gene ID

10277

5195

Gene nameubiquitination factor E4Bperoxisomal biogenesis factor 14
SynonymsE4|HDNB1|UBOX3|UFD2|UFD2ANAPP2|PBD13A|Pex14p|dJ734G22.2
Cytomap

1p36.22

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionubiquitin conjugation factor E4 BRING-type E3 ubiquitin transferase E4 BUFD2A-III/UBE4B-III splice isoformhomologous to yeast UFD2homozygously deleted in neuroblastoma-1ubiquitin-fusion degradation protein 2ubiquitination factor E4B (UFD2 homolog, yperoxisomal membrane protein PEX14NF-E2 associated polypeptide 2PTS1 receptor docking proteinperoxin-14peroxisomal membrane anchor protein PEX14peroxisomal membrane anchor protein Pex14p
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000253251, ENST00000377157, 
ENST00000343090, ENST00000377153, 
ENST00000475795, 		ENST00000356607, 
ENST00000538836, ENST00000492696, 
Fusion gene scores* DoF score18 X 13 X 10=234013 X 10 X 7=910
# samples 2313
** MAII scorelog2(23/2340*10)=-3.34680276352639
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE4B [Title/Abstract] AND PEX14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUBE4B(10093752)-PEX14(10596270), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE4B

GO:0008626

granzyme-mediated apoptotic signaling pathway

11802788

HgeneUBE4B

GO:0009411

response to UV

11802788

HgeneUBE4B

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

23509263

TgenePEX14

GO:0016561

protein import into peroxisome matrix, translocation

21525035

TgenePEX14

GO:0032091

negative regulation of protein binding

21976670

TgenePEX14

GO:0034453

microtubule anchoring

21525035

TgenePEX14

GO:0036250

peroxisome transport along microtubule

21525035

TgenePEX14

GO:0043433

negative regulation of DNA-binding transcription factor activity

11863372

TgenePEX14

GO:0044721

protein import into peroxisome matrix, substrate release

21976670

TgenePEX14

GO:0045892

negative regulation of transcription, DNA-templated

11863372

TgenePEX14

GO:0065003

protein-containing complex assembly

21525035


check buttonFusion gene breakpoints across UBE4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PEX14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BA-A6DJ-01AUBE4Bchr1

10093752

+PEX14chr1

10596270

+
ChimerDB4HNSCTCGA-BA-A6DJUBE4Bchr1

10093752

+PEX14chr1

10596270

+
ChiTaRS5.0N/ABF197650UBE4Bchr1

10161697

+PEX14chr1

10548688

+


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Fusion Gene ORF analysis for UBE4B-PEX14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000253251ENST00000356607UBE4Bchr1

10093752

+PEX14chr1

10596270

+
5CDS-intronENST00000253251ENST00000538836UBE4Bchr1

10093752

+PEX14chr1

10596270

+
5CDS-3UTRENST00000253251ENST00000492696UBE4Bchr1

10093752

+PEX14chr1

10596270

+
5UTR-3CDSENST00000377157ENST00000356607UBE4Bchr1

10093752

+PEX14chr1

10596270

+
5UTR-intronENST00000377157ENST00000538836UBE4Bchr1

10093752

+PEX14chr1

10596270

+
5UTR-3UTRENST00000377157ENST00000492696UBE4Bchr1

10093752

+PEX14chr1

10596270

+
In-frameENST00000343090ENST00000356607UBE4Bchr1

10093752

+PEX14chr1

10596270

+
5CDS-intronENST00000343090ENST00000538836UBE4Bchr1

10093752

+PEX14chr1

10596270

+
5CDS-3UTRENST00000343090ENST00000492696UBE4Bchr1

10093752

+PEX14chr1

10596270

+
In-frameENST00000377153ENST00000356607UBE4Bchr1

10093752

+PEX14chr1

10596270

+
5CDS-intronENST00000377153ENST00000538836UBE4Bchr1

10093752

+PEX14chr1

10596270

+
5CDS-3UTRENST00000377153ENST00000492696UBE4Bchr1

10093752

+PEX14chr1

10596270

+
intron-3CDSENST00000475795ENST00000356607UBE4Bchr1

10093752

+PEX14chr1

10596270

+
intron-intronENST00000475795ENST00000538836UBE4Bchr1

10093752

+PEX14chr1

10596270

+
intron-3UTRENST00000475795ENST00000492696UBE4Bchr1

10093752

+PEX14chr1

10596270

+
intron-intronENST00000253251ENST00000356607UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000253251ENST00000538836UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000253251ENST00000492696UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000377157ENST00000356607UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000377157ENST00000538836UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000377157ENST00000492696UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000343090ENST00000356607UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000343090ENST00000538836UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000343090ENST00000492696UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000377153ENST00000356607UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000377153ENST00000538836UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000377153ENST00000492696UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000475795ENST00000356607UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000475795ENST00000538836UBE4Bchr1

10161697

+PEX14chr1

10548688

+
intron-intronENST00000475795ENST00000492696UBE4Bchr1

10161697

+PEX14chr1

10548688

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000253251UBE4Bchr110093752+ENST00000356607PEX14chr110596270+26848638391912357
ENST00000343090UBE4Bchr110093752+ENST00000356607PEX14chr110596270+192099751148357
ENST00000377153UBE4Bchr110093752+ENST00000356607PEX14chr110596270+22424213971470357

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253251ENST00000356607UBE4Bchr110093752+PEX14chr110596270+0.0038474310.9961526
ENST00000343090ENST00000356607UBE4Bchr110093752+PEX14chr110596270+0.0041698310.9958301
ENST00000377153ENST00000356607UBE4Bchr110093752+PEX14chr110596270+0.0047152710.99528474

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Fusion Genomic Features for UBE4B-PEX14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
UBE4Bchr110093752+PEX14chr110596269+1.31E-070.9999999
UBE4Bchr110093752+PEX14chr110596269+1.31E-070.9999999
UBE4Bchr110093752+PEX14chr110596269+1.31E-070.9999999
UBE4Bchr110093752+PEX14chr110596269+1.31E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBE4B-PEX14


check button Go to

FGviewer for the breakpoints of chr1:10093752-chr1:10596270

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBE4Bchr1:10093752chr1:10596270ENST00000253251+1271227_13008.01174.0DomainNote=U-box
HgeneUBE4Bchr1:10093752chr1:10596270ENST00000343090+1281227_13008.01303.0DomainNote=U-box
HgeneUBE4Bchr1:10093752chr1:10596270ENST00000377157+1271227_130001062.0DomainNote=U-box


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Fusion Gene Sequence for UBE4B-PEX14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000253251_ENST00000356607_TCGA-BA-A6DJ-01A_UBE4B_chr1_10093752_+_PEX14_chr1_10596270_length(transcript)=2684nt_BP=863nt
GACGGGGTGGGACGGAGGCGGGGAGAGGACGCAGGCGAGAGGAACTCGGCGGCGCGGCGCCCGCGGCCTATTGGCTGCCACGTCCCGGCG
CCAGAAGCCCCGCCTCCCTGACGGGGGTCACGTGATCCCTTTCAAAGATGGCCGCCCTGTTGTTTTGATGAATAATACTTGGTGGGGCGA
GGGGGAAAGAGTAGGGGTGGAGGGGTAGGAGGATTTACTCTTCCAGCGAGAGCTACGCGCATCCCATCCTCCCCCTCCCCCCTACCCGGG
CTCCGGCGTGGAGGCGGGGCGTGGCCGGCCTGCTTTGGGAGGGGAGGGGCTTCCCTTACAGTGCTGGGCTCTGCCAGGACGGCTGTGGGG
TCGCCTTACCTCGGGGTATCCACTCTGCAGTCGACCAGTTCCCGCCAGGAGCAAAGGGTAGGAAGGAGAGCAGGATCTGCTGTAGGAACG
CAGCTACCGCGCCACTATCACGAAGAAACAGCAGGCTCGGGGCACGAGACGAACTGGAGACCGCGCTGCCTAGCTGGGTAACCTGGGAAG
CAGAGGGTAATAAGTGGCGCCTTAAGACAACCCTGTAGCAGCAGCAGTGGCGGCCAAAGGAGGCTGCTCAGGGAACAAGCGGCTGTAGTA
GTCTGTGGGGCGACTGGAGTGACCGAAGCCAAGGCAGTTTAGTGCCTCTCGTGTTCTTATTTTTTAACCTCTGACTATGCAATTCTGAAA
CCTCCCCCATTCGGGGGACCAGACAGCCTGATAGACACCTTCCACTCTCCTTCCTCCCGCCGTGGTCTCGAGAACAGAAGGATCTCTCCT
TAACGCCTTTCACCATTAAGAGGAAAGCGATGGAGGAGCTGAGCGCTGATGAGATTGCCACGGCAGTGAAGTTTCTACAGAATTCCCGGG
TCCGCCAGAGCCCACTTGCAACCAGGAGAGCATTCCTAAAGAAGAAAGGGCTGACAGATGAAGAGATTGATATGGCCTTCCAGCAGTCGG
GCACTGCTGCCGATGAGCCTTCGTCCTTGGGCCCAGCCACACAGGTGGTTCCTGTCCAGCCCCCTCACCTCATATCTCAGCCATACAGTC
CCGCAGGCTCCCGATGGCGAGATTACGGCGCCCTGGCCATCATCATGGCAGGCATTGCATTTGGCTTTCACCAGCTCTACAAGAAATACC
TGCTCCCCCTCATCCTGGGCGGCCGAGAGGACAGAAAGCAGCTGGAGAGGATGGAGGCCGGTCTCTCTGAGCTGAGTGGCAGCGTGGCCC
AGACAGTGACTCAGTTACAGACGACCCTCGCCTCCGTCCAGGAGCTGCTGATTCAGCAGCAGCAGAAGATCCAGGAGCTTGCCCACGAGC
TGGCCGCTGCCAAGGCCACCACATCCACCAACTGGATCCTGGAGTCCCAGAATATCAACGAACTCAAGTCCGAAATTAACTCCTTGAAAG
GGCTTCTTTTAAATCGGAGGCAGTTCCCTCCATCCCCATCAGCCCCGAAGATCCCCTCCTGGCAGATCCCAGTCAAGTCACCGTCACCCT
CCAGCCCTGCGGCCGTGAACCACCACAGCAGCAGCGACATCTCACCTGTCAGCAACGAGTCCACGTCGTCCTCGCCTGGGAAGGAGGGCC
ACAGCCCCGAGGGCTCCACGGTCACCTACCACTTGCTGGGCCCCCAGGAGGAAGGCGAGGGGGTGGTGGACGTCAAGGGCCAGGTGCGGA
TGGAGGTGCAAGGCGAGGAGGAGAAGAGGGAGGACAAGGAGGACGAGGAGGATGAGGAGGATGATGATGTGAGCCATGTGGACGAGGAGG
ACTGCCTGGGGGTGCAGAGGGAGGACCGCCGGGGCGGGGATGGGCAGATCAACGAGCAGGTGGAGAAGCTGCGGCGGCCCGAGGGCGCCA
GCAACGAGAGTGAGCGGGACTAGGGCTGCGCCTGCTGCCTCCAGCCCTGAGGATGGCATCTAGTGTGCCCGTGCGTGGCCATACCCTGCC
TCCCTCTCTGGCCCTGGGAGGGCAGCTTGGAGCCCAGGTAGGGGGCAGAGCTGTCCTCAGCTGCACTGCGGCCTGGTGGCAGTGTGGGGA
GTCACACTTCTGTCCACCTGGCCTCCTCTCGCCTGGCCGCCAGCCCCAGCCCCAGCCCCAGCCCCAGGCCCAGCTGCCTTTGGCTTTGAT
CTCAAGTCAGGCTGAAGGCAGCGAAGCCTCGGGGCCCAAGCCCCTCCCCAGCCCCCTCTCCCGGACAGACGCCTTGCCCAGGGTGTGTTT
GCTGAGTGTCTTGACTACCGTGACACCACGCATGGCCAGAGCTAGCGTCCCTACTGCCTCCCGACTCCTCAGTGGAGGAGGAGCTGCGGT
CCCTCTGGTGTCTGCCATCCCCCTCCCTCCCTGGGCCCGGCCCTGGACCCGTCAGGTGCCTGTCCCCAGCCCCAACCCCACTCATGCCCC
GTCGTCCTCCCAGACAAATGAAACCACGCTGCGCTTCCGATGCCCCCGCTTGCCGTGTAATGGTTCAGCTAATCCCATGGCGAGATGGGG
GCTCACTCCGGAGGAGGAGCCAGGCAGCAGGGCCTTCCTGACCAACAGCCAGCTCTGTCCTTCCCCCCAGGAAACACATGTTCATTTGTG

>In-frame_ENST00000253251_ENST00000356607_TCGA-BA-A6DJ-01A_UBE4B_chr1_10093752_+_PEX14_chr1_10596270_length(amino acids)=357AA_start in transcript=839_stop in transcript=1912
MEELSADEIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYG
ALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTST
NWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTY

--------------------------------------------------------------
>In-frame_ENST00000343090_ENST00000356607_TCGA-BA-A6DJ-01A_UBE4B_chr1_10093752_+_PEX14_chr1_10596270_length(transcript)=1920nt_BP=99nt
CTCTCCTTCCTCCCGCCGTGGTCTCGAGAACAGAAGGATCTCTCCTTAACGCCTTTCACCATTAAGAGGAAAGCGATGGAGGAGCTGAGC
GCTGATGAGATTGCCACGGCAGTGAAGTTTCTACAGAATTCCCGGGTCCGCCAGAGCCCACTTGCAACCAGGAGAGCATTCCTAAAGAAG
AAAGGGCTGACAGATGAAGAGATTGATATGGCCTTCCAGCAGTCGGGCACTGCTGCCGATGAGCCTTCGTCCTTGGGCCCAGCCACACAG
GTGGTTCCTGTCCAGCCCCCTCACCTCATATCTCAGCCATACAGTCCCGCAGGCTCCCGATGGCGAGATTACGGCGCCCTGGCCATCATC
ATGGCAGGCATTGCATTTGGCTTTCACCAGCTCTACAAGAAATACCTGCTCCCCCTCATCCTGGGCGGCCGAGAGGACAGAAAGCAGCTG
GAGAGGATGGAGGCCGGTCTCTCTGAGCTGAGTGGCAGCGTGGCCCAGACAGTGACTCAGTTACAGACGACCCTCGCCTCCGTCCAGGAG
CTGCTGATTCAGCAGCAGCAGAAGATCCAGGAGCTTGCCCACGAGCTGGCCGCTGCCAAGGCCACCACATCCACCAACTGGATCCTGGAG
TCCCAGAATATCAACGAACTCAAGTCCGAAATTAACTCCTTGAAAGGGCTTCTTTTAAATCGGAGGCAGTTCCCTCCATCCCCATCAGCC
CCGAAGATCCCCTCCTGGCAGATCCCAGTCAAGTCACCGTCACCCTCCAGCCCTGCGGCCGTGAACCACCACAGCAGCAGCGACATCTCA
CCTGTCAGCAACGAGTCCACGTCGTCCTCGCCTGGGAAGGAGGGCCACAGCCCCGAGGGCTCCACGGTCACCTACCACTTGCTGGGCCCC
CAGGAGGAAGGCGAGGGGGTGGTGGACGTCAAGGGCCAGGTGCGGATGGAGGTGCAAGGCGAGGAGGAGAAGAGGGAGGACAAGGAGGAC
GAGGAGGATGAGGAGGATGATGATGTGAGCCATGTGGACGAGGAGGACTGCCTGGGGGTGCAGAGGGAGGACCGCCGGGGCGGGGATGGG
CAGATCAACGAGCAGGTGGAGAAGCTGCGGCGGCCCGAGGGCGCCAGCAACGAGAGTGAGCGGGACTAGGGCTGCGCCTGCTGCCTCCAG
CCCTGAGGATGGCATCTAGTGTGCCCGTGCGTGGCCATACCCTGCCTCCCTCTCTGGCCCTGGGAGGGCAGCTTGGAGCCCAGGTAGGGG
GCAGAGCTGTCCTCAGCTGCACTGCGGCCTGGTGGCAGTGTGGGGAGTCACACTTCTGTCCACCTGGCCTCCTCTCGCCTGGCCGCCAGC
CCCAGCCCCAGCCCCAGCCCCAGGCCCAGCTGCCTTTGGCTTTGATCTCAAGTCAGGCTGAAGGCAGCGAAGCCTCGGGGCCCAAGCCCC
TCCCCAGCCCCCTCTCCCGGACAGACGCCTTGCCCAGGGTGTGTTTGCTGAGTGTCTTGACTACCGTGACACCACGCATGGCCAGAGCTA
GCGTCCCTACTGCCTCCCGACTCCTCAGTGGAGGAGGAGCTGCGGTCCCTCTGGTGTCTGCCATCCCCCTCCCTCCCTGGGCCCGGCCCT
GGACCCGTCAGGTGCCTGTCCCCAGCCCCAACCCCACTCATGCCCCGTCGTCCTCCCAGACAAATGAAACCACGCTGCGCTTCCGATGCC
CCCGCTTGCCGTGTAATGGTTCAGCTAATCCCATGGCGAGATGGGGGCTCACTCCGGAGGAGGAGCCAGGCAGCAGGGCCTTCCTGACCA
ACAGCCAGCTCTGTCCTTCCCCCCAGGAAACACATGTTCATTTGTGTGATCATGTATAGACCTCAGAACGGAAGATAGGACTGTATATAA

>In-frame_ENST00000343090_ENST00000356607_TCGA-BA-A6DJ-01A_UBE4B_chr1_10093752_+_PEX14_chr1_10596270_length(amino acids)=357AA_start in transcript=75_stop in transcript=1148
MEELSADEIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYG
ALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTST
NWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTY

--------------------------------------------------------------
>In-frame_ENST00000377153_ENST00000356607_TCGA-BA-A6DJ-01A_UBE4B_chr1_10093752_+_PEX14_chr1_10596270_length(transcript)=2242nt_BP=421nt
TAGGAACGCAGCTACCGCGCCACTATCACGAAGAAACAGCAGGCTCGGGGCACGAGACGAACTGGAGACCGCGCTGCCTAGCTGGGTAAC
CTGGGAAGCAGAGGGTAATAAGTGGCGCCTTAAGACAACCCTGTAGCAGCAGCAGTGGCGGCCAAAGGAGGCTGCTCAGGGAACAAGCGG
CTGTAGTAGTCTGTGGGGCGACTGGAGTGACCGAAGCCAAGGCAGTTTAGTGCCTCTCGTGTTCTTATTTTTTAACCTCTGACTATGCAA
TTCTGAAACCTCCCCCATTCGGGGGACCAGACAGCCTGATAGACACCTTCCACTCTCCTTCCTCCCGCCGTGGTCTCGAGAACAGAAGGA
TCTCTCCTTAACGCCTTTCACCATTAAGAGGAAAGCGATGGAGGAGCTGAGCGCTGATGAGATTGCCACGGCAGTGAAGTTTCTACAGAA
TTCCCGGGTCCGCCAGAGCCCACTTGCAACCAGGAGAGCATTCCTAAAGAAGAAAGGGCTGACAGATGAAGAGATTGATATGGCCTTCCA
GCAGTCGGGCACTGCTGCCGATGAGCCTTCGTCCTTGGGCCCAGCCACACAGGTGGTTCCTGTCCAGCCCCCTCACCTCATATCTCAGCC
ATACAGTCCCGCAGGCTCCCGATGGCGAGATTACGGCGCCCTGGCCATCATCATGGCAGGCATTGCATTTGGCTTTCACCAGCTCTACAA
GAAATACCTGCTCCCCCTCATCCTGGGCGGCCGAGAGGACAGAAAGCAGCTGGAGAGGATGGAGGCCGGTCTCTCTGAGCTGAGTGGCAG
CGTGGCCCAGACAGTGACTCAGTTACAGACGACCCTCGCCTCCGTCCAGGAGCTGCTGATTCAGCAGCAGCAGAAGATCCAGGAGCTTGC
CCACGAGCTGGCCGCTGCCAAGGCCACCACATCCACCAACTGGATCCTGGAGTCCCAGAATATCAACGAACTCAAGTCCGAAATTAACTC
CTTGAAAGGGCTTCTTTTAAATCGGAGGCAGTTCCCTCCATCCCCATCAGCCCCGAAGATCCCCTCCTGGCAGATCCCAGTCAAGTCACC
GTCACCCTCCAGCCCTGCGGCCGTGAACCACCACAGCAGCAGCGACATCTCACCTGTCAGCAACGAGTCCACGTCGTCCTCGCCTGGGAA
GGAGGGCCACAGCCCCGAGGGCTCCACGGTCACCTACCACTTGCTGGGCCCCCAGGAGGAAGGCGAGGGGGTGGTGGACGTCAAGGGCCA
GGTGCGGATGGAGGTGCAAGGCGAGGAGGAGAAGAGGGAGGACAAGGAGGACGAGGAGGATGAGGAGGATGATGATGTGAGCCATGTGGA
CGAGGAGGACTGCCTGGGGGTGCAGAGGGAGGACCGCCGGGGCGGGGATGGGCAGATCAACGAGCAGGTGGAGAAGCTGCGGCGGCCCGA
GGGCGCCAGCAACGAGAGTGAGCGGGACTAGGGCTGCGCCTGCTGCCTCCAGCCCTGAGGATGGCATCTAGTGTGCCCGTGCGTGGCCAT
ACCCTGCCTCCCTCTCTGGCCCTGGGAGGGCAGCTTGGAGCCCAGGTAGGGGGCAGAGCTGTCCTCAGCTGCACTGCGGCCTGGTGGCAG
TGTGGGGAGTCACACTTCTGTCCACCTGGCCTCCTCTCGCCTGGCCGCCAGCCCCAGCCCCAGCCCCAGCCCCAGGCCCAGCTGCCTTTG
GCTTTGATCTCAAGTCAGGCTGAAGGCAGCGAAGCCTCGGGGCCCAAGCCCCTCCCCAGCCCCCTCTCCCGGACAGACGCCTTGCCCAGG
GTGTGTTTGCTGAGTGTCTTGACTACCGTGACACCACGCATGGCCAGAGCTAGCGTCCCTACTGCCTCCCGACTCCTCAGTGGAGGAGGA
GCTGCGGTCCCTCTGGTGTCTGCCATCCCCCTCCCTCCCTGGGCCCGGCCCTGGACCCGTCAGGTGCCTGTCCCCAGCCCCAACCCCACT
CATGCCCCGTCGTCCTCCCAGACAAATGAAACCACGCTGCGCTTCCGATGCCCCCGCTTGCCGTGTAATGGTTCAGCTAATCCCATGGCG
AGATGGGGGCTCACTCCGGAGGAGGAGCCAGGCAGCAGGGCCTTCCTGACCAACAGCCAGCTCTGTCCTTCCCCCCAGGAAACACATGTT

>In-frame_ENST00000377153_ENST00000356607_TCGA-BA-A6DJ-01A_UBE4B_chr1_10093752_+_PEX14_chr1_10596270_length(amino acids)=357AA_start in transcript=397_stop in transcript=1470
MEELSADEIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYG
ALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTST
NWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTY

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Fusion Gene PPI Analysis for UBE4B-PEX14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UBE4B-PEX14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UBE4B-PEX14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUBE4BC0004238Atrial Fibrillation1CTD_human
HgeneUBE4BC0043020Wallerian Degeneration1CTD_human
HgeneUBE4BC0235480Paroxysmal atrial fibrillation1CTD_human
HgeneUBE4BC0525041Neurobehavioral Manifestations1CTD_human
HgeneUBE4BC2585653Persistent atrial fibrillation1CTD_human
HgeneUBE4BC3468561familial atrial fibrillation1CTD_human
TgenePEX14C3554004PEROXISOME BIOGENESIS DISORDER 13A (ZELLWEGER)5CTD_human;GENOMICS_ENGLAND
TgenePEX14C1832200Peroxisome biogenesis disorders4CTD_human;GENOMICS_ENGLAND
TgenePEX14C0043459Zellweger Syndrome2CTD_human;GENOMICS_ENGLAND
TgenePEX14C0751594Zellweger-Like Syndrome2CTD_human
TgenePEX14C3658299Zellweger Spectrum2CTD_human
TgenePEX14C0010093Corpus Luteum Cyst1CTD_human
TgenePEX14C0029927Ovarian Cysts1CTD_human