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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UBXN11-ZNF683 (FusionGDB2 ID:95851)

Fusion Gene Summary for UBXN11-ZNF683

check button Fusion gene summary
Fusion gene informationFusion gene name: UBXN11-ZNF683
Fusion gene ID: 95851
HgeneTgene
Gene symbol

UBXN11

ZNF683

Gene ID

91544

257101

Gene nameUBX domain protein 11zinc finger protein 683
SynonymsCOA-1|PP2243|SOC|SOCI|UBXD5Hobit
Cytomap

1p36.11

1p36.11

Type of geneprotein-codingprotein-coding
DescriptionUBX domain-containing protein 11UBX domain-containing protein 5colorectal tumor-associated antigen COA-1colorectal tumor-associated antigen-1sociustissue-resident T-cell transcription regulator protein ZNF683homolog of Blimp-1 in T cellshomolog of Blimp-1 in T-cellhypothetical protein MGC33414
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000314675, ENST00000374223, 
ENST00000357089, ENST00000374221, 
ENST00000374217, ENST00000374222, 
ENST00000535108, ENST00000436301, 
ENST00000403843, ENST00000436292, 
ENST00000374204, ENST00000349618, 
Fusion gene scores* DoF score6 X 6 X 3=1082 X 2 X 2=8
# samples 62
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: UBXN11 [Title/Abstract] AND ZNF683 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUBXN11(26623410)-ZNF683(26689645), # samples:1
Anticipated loss of major functional domain due to fusion event.UBXN11-ZNF683 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across UBXN11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZNF683 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3858-01AUBXN11chr1

26623410

-ZNF683chr1

26689645

-


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Fusion Gene ORF analysis for UBXN11-ZNF683

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000314675ENST00000403843UBXN11chr1

26623410

-ZNF683chr1

26689645

-
intron-3CDSENST00000314675ENST00000436292UBXN11chr1

26623410

-ZNF683chr1

26689645

-
intron-3CDSENST00000314675ENST00000374204UBXN11chr1

26623410

-ZNF683chr1

26689645

-
intron-3CDSENST00000314675ENST00000349618UBXN11chr1

26623410

-ZNF683chr1

26689645

-
5UTR-3CDSENST00000374223ENST00000403843UBXN11chr1

26623410

-ZNF683chr1

26689645

-
5UTR-3CDSENST00000374223ENST00000436292UBXN11chr1

26623410

-ZNF683chr1

26689645

-
5UTR-3CDSENST00000374223ENST00000374204UBXN11chr1

26623410

-ZNF683chr1

26689645

-
5UTR-3CDSENST00000374223ENST00000349618UBXN11chr1

26623410

-ZNF683chr1

26689645

-
Frame-shiftENST00000357089ENST00000403843UBXN11chr1

26623410

-ZNF683chr1

26689645

-
Frame-shiftENST00000357089ENST00000436292UBXN11chr1

26623410

-ZNF683chr1

26689645

-
Frame-shiftENST00000357089ENST00000374204UBXN11chr1

26623410

-ZNF683chr1

26689645

-
Frame-shiftENST00000357089ENST00000349618UBXN11chr1

26623410

-ZNF683chr1

26689645

-
Frame-shiftENST00000374221ENST00000403843UBXN11chr1

26623410

-ZNF683chr1

26689645

-
Frame-shiftENST00000374221ENST00000436292UBXN11chr1

26623410

-ZNF683chr1

26689645

-
Frame-shiftENST00000374221ENST00000374204UBXN11chr1

26623410

-ZNF683chr1

26689645

-
Frame-shiftENST00000374221ENST00000349618UBXN11chr1

26623410

-ZNF683chr1

26689645

-
In-frameENST00000374217ENST00000403843UBXN11chr1

26623410

-ZNF683chr1

26689645

-
In-frameENST00000374217ENST00000436292UBXN11chr1

26623410

-ZNF683chr1

26689645

-
In-frameENST00000374217ENST00000374204UBXN11chr1

26623410

-ZNF683chr1

26689645

-
In-frameENST00000374217ENST00000349618UBXN11chr1

26623410

-ZNF683chr1

26689645

-
In-frameENST00000374222ENST00000403843UBXN11chr1

26623410

-ZNF683chr1

26689645

-
In-frameENST00000374222ENST00000436292UBXN11chr1

26623410

-ZNF683chr1

26689645

-
In-frameENST00000374222ENST00000374204UBXN11chr1

26623410

-ZNF683chr1

26689645

-
In-frameENST00000374222ENST00000349618UBXN11chr1

26623410

-ZNF683chr1

26689645

-
intron-3CDSENST00000535108ENST00000403843UBXN11chr1

26623410

-ZNF683chr1

26689645

-
intron-3CDSENST00000535108ENST00000436292UBXN11chr1

26623410

-ZNF683chr1

26689645

-
intron-3CDSENST00000535108ENST00000374204UBXN11chr1

26623410

-ZNF683chr1

26689645

-
intron-3CDSENST00000535108ENST00000349618UBXN11chr1

26623410

-ZNF683chr1

26689645

-
Frame-shiftENST00000436301ENST00000403843UBXN11chr1

26623410

-ZNF683chr1

26689645

-
Frame-shiftENST00000436301ENST00000436292UBXN11chr1

26623410

-ZNF683chr1

26689645

-
Frame-shiftENST00000436301ENST00000374204UBXN11chr1

26623410

-ZNF683chr1

26689645

-
Frame-shiftENST00000436301ENST00000349618UBXN11chr1

26623410

-ZNF683chr1

26689645

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for UBXN11-ZNF683


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBXN11-ZNF683


check button Go to

FGviewer for the breakpoints of chr1:26623410-chr1:26689645

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF683chr1:26623410chr1:26689645ENST0000034961836350_372338.0505.0Zinc fingerC2H2-type 2
TgeneZNF683chr1:26623410chr1:26689645ENST0000034961836398_420338.0505.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF683chr1:26623410chr1:26689645ENST0000034961836426_448338.0505.0Zinc fingerC2H2-type 4
TgeneZNF683chr1:26623410chr1:26689645ENST0000037420436350_372338.0505.0Zinc fingerC2H2-type 2
TgeneZNF683chr1:26623410chr1:26689645ENST0000037420436398_420338.0505.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF683chr1:26623410chr1:26689645ENST0000037420436426_448338.0505.0Zinc fingerC2H2-type 4
TgeneZNF683chr1:26623410chr1:26689645ENST0000040384337350_372338.0525.0Zinc fingerC2H2-type 2
TgeneZNF683chr1:26623410chr1:26689645ENST0000040384337398_420338.0525.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF683chr1:26623410chr1:26689645ENST0000040384337426_448338.0525.0Zinc fingerC2H2-type 4
TgeneZNF683chr1:26623410chr1:26689645ENST0000043629237350_372338.0525.0Zinc fingerC2H2-type 2
TgeneZNF683chr1:26623410chr1:26689645ENST0000043629237398_420338.0525.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF683chr1:26623410chr1:26689645ENST0000043629237426_448338.0525.0Zinc fingerC2H2-type 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBXN11chr1:26623410chr1:26689645ENST00000314675-11176_1490401.0Coiled coilOntology_term=ECO:0000255
HgeneUBXN11chr1:26623410chr1:26689645ENST00000357089-61476_149111.0488.0Coiled coilOntology_term=ECO:0000255
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374217-71576_149111.0488.0Coiled coilOntology_term=ECO:0000255
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374221-81676_149144.0521.0Coiled coilOntology_term=ECO:0000255
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374222-81676_149144.0521.0Coiled coilOntology_term=ECO:0000255
HgeneUBXN11chr1:26623410chr1:26689645ENST00000314675-111483_5190401.0Compositional biasNote=Pro-rich
HgeneUBXN11chr1:26623410chr1:26689645ENST00000357089-614483_519111.0488.0Compositional biasNote=Pro-rich
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374217-715483_519111.0488.0Compositional biasNote=Pro-rich
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374221-816483_519144.0521.0Compositional biasNote=Pro-rich
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374222-816483_519144.0521.0Compositional biasNote=Pro-rich
HgeneUBXN11chr1:26623410chr1:26689645ENST00000314675-111230_2940401.0DomainSEP
HgeneUBXN11chr1:26623410chr1:26689645ENST00000314675-111392_4690401.0DomainUBX
HgeneUBXN11chr1:26623410chr1:26689645ENST00000357089-614230_294111.0488.0DomainSEP
HgeneUBXN11chr1:26623410chr1:26689645ENST00000357089-614392_469111.0488.0DomainUBX
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374217-715230_294111.0488.0DomainSEP
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374217-715392_469111.0488.0DomainUBX
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374221-816230_294144.0521.0DomainSEP
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374221-816392_469144.0521.0DomainUBX
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374222-816230_294144.0521.0DomainSEP
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374222-816392_469144.0521.0DomainUBX
HgeneUBXN11chr1:26623410chr1:26689645ENST00000314675-111487_5100401.0RegionNote=3 X 8 AA tandem repeats of P-G-P-G-P-G-P-S
HgeneUBXN11chr1:26623410chr1:26689645ENST00000357089-614487_510111.0488.0RegionNote=3 X 8 AA tandem repeats of P-G-P-G-P-G-P-S
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374217-715487_510111.0488.0RegionNote=3 X 8 AA tandem repeats of P-G-P-G-P-G-P-S
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374221-816487_510144.0521.0RegionNote=3 X 8 AA tandem repeats of P-G-P-G-P-G-P-S
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374222-816487_510144.0521.0RegionNote=3 X 8 AA tandem repeats of P-G-P-G-P-G-P-S
HgeneUBXN11chr1:26623410chr1:26689645ENST00000314675-111495_5020401.0RepeatNote=2
HgeneUBXN11chr1:26623410chr1:26689645ENST00000314675-111503_5100401.0RepeatNote=3
HgeneUBXN11chr1:26623410chr1:26689645ENST00000357089-614495_502111.0488.0RepeatNote=2
HgeneUBXN11chr1:26623410chr1:26689645ENST00000357089-614503_510111.0488.0RepeatNote=3
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374217-715495_502111.0488.0RepeatNote=2
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374217-715503_510111.0488.0RepeatNote=3
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374221-816495_502144.0521.0RepeatNote=2
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374221-816503_510144.0521.0RepeatNote=3
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374222-816495_502144.0521.0RepeatNote=2
HgeneUBXN11chr1:26623410chr1:26689645ENST00000374222-816503_510144.0521.0RepeatNote=3
TgeneZNF683chr1:26623410chr1:26689645ENST0000034961836322_344338.0505.0Zinc fingerC2H2-type 1
TgeneZNF683chr1:26623410chr1:26689645ENST0000037420436322_344338.0505.0Zinc fingerC2H2-type 1
TgeneZNF683chr1:26623410chr1:26689645ENST0000040384337322_344338.0525.0Zinc fingerC2H2-type 1
TgeneZNF683chr1:26623410chr1:26689645ENST0000043629237322_344338.0525.0Zinc fingerC2H2-type 1


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Fusion Gene Sequence for UBXN11-ZNF683


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for UBXN11-ZNF683


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UBXN11-ZNF683


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UBXN11-ZNF683


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZNF683C0263454Chloracne1CTD_human