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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:UGDH-RFC1 (FusionGDB2 ID:95969)

Fusion Gene Summary for UGDH-RFC1

Fusion gene summary

Fusion gene information	Fusion gene name: UGDH-RFC1
	Fusion gene ID: 95969
		Hgene	Tgene
	Gene symbol	UGDH	RFC1
	Gene ID	7358	6573
	Gene name	UDP-glucose 6-dehydrogenase	solute carrier family 19 member 1
	Synonyms	EIEE84\|GDH\|UDP-GlcDH\|UDPGDH\|UGD	CHMD\|FOLT\|IFC-1\|IFC1\|REFC\|RFC\|RFC1\|RFT-1\|hRFC\|hSLC19A1
	Cytomap	4p14	21q22.3
	Type of gene	protein-coding	protein-coding
	Description	UDP-glucose 6-dehydrogenaseUDP-Glc dehydrogenaseUDP-glucose dehydrogenaseuridine diphospho-glucose dehydrogenase	reduced folate transporterfolate transporter 1intestinal folate carrier 1placental folate transporterreduced folate carrier 1reduced folate carrier proteinreduced folate transporter 1solute carrier family 19 (folate transporter), member 1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000316423, ENST00000501493, ENST00000506179, ENST00000507089, ENST00000515398,	ENST00000349703, ENST00000381897, ENST00000418436,
Fusion gene scores	* DoF score	6 X 6 X 5=180	5 X 5 X 3=75
	# samples	7	5
	** MAII score	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UGDH [Title/Abstract] AND RFC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UGDH(39522970)-RFC1(39322994), # samples:1
Anticipated loss of major functional domain due to fusion event.	UGDH-RFC1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. UGDH-RFC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. UGDH-RFC1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UGDH	GO:0006065	UDP-glucuronate biosynthetic process	27966912
Hgene	UGDH	GO:0034214	protein hexamerization	27966912
Tgene	RFC1	GO:0051958	methotrexate transport	22554803
Tgene	RFC1	GO:0098838	folate transmembrane transport	22554803
Tgene	RFC1	GO:1904447	folate import across plasma membrane	14609557\|22554803

Fusion gene breakpoints across UGDH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RFC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-A48A	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-

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Fusion Gene ORF analysis for UGDH-RFC1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000316423	ENST00000349703	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
In-frame	ENST00000316423	ENST00000381897	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
5CDS-5UTR	ENST00000316423	ENST00000418436	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
In-frame	ENST00000501493	ENST00000349703	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
In-frame	ENST00000501493	ENST00000381897	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
5CDS-5UTR	ENST00000501493	ENST00000418436	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
Frame-shift	ENST00000506179	ENST00000349703	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
Frame-shift	ENST00000506179	ENST00000381897	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
5CDS-5UTR	ENST00000506179	ENST00000418436	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
intron-3CDS	ENST00000507089	ENST00000349703	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
intron-3CDS	ENST00000507089	ENST00000381897	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
intron-5UTR	ENST00000507089	ENST00000418436	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
intron-3CDS	ENST00000515398	ENST00000349703	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
intron-3CDS	ENST00000515398	ENST00000381897	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-
intron-5UTR	ENST00000515398	ENST00000418436	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000316423	UGDH	chr4	39522970	-	ENST00000349703	RFC1	chr4	39322994	-	4534	505	313	3228	971
ENST00000316423	UGDH	chr4	39522970	-	ENST00000381897	RFC1	chr4	39322994	-	4537	505	313	3231	972
ENST00000501493	UGDH	chr4	39522970	-	ENST00000349703	RFC1	chr4	39322994	-	4353	324	132	3047	971
ENST00000501493	UGDH	chr4	39522970	-	ENST00000381897	RFC1	chr4	39322994	-	4356	324	132	3050	972

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000316423	ENST00000349703	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-	0.000169849	0.9998301
ENST00000316423	ENST00000381897	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-	0.000173551	0.9998265
ENST00000501493	ENST00000349703	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-	0.000156393	0.9998436
ENST00000501493	ENST00000381897	UGDH	chr4	39522970	-	RFC1	chr4	39322994	-	0.000159958	0.99984

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Fusion Genomic Features for UGDH-RFC1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UGDH-RFC1

Go to
FGviewer for the breakpoints of chr4:39522970-chr4:39322994
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000316423

11_16

54.0

495.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000501493

11_16

54.0

428.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000506179

11_16

54.0

495.0

Nucleotide binding

NAD

Tgene

RFC1

chr4:39522970

chr4:39322994

ENST00000349703

402_492

240.0

1148.0

Domain

BRCT

Tgene

RFC1

chr4:39522970

chr4:39322994

ENST00000381897

402_492

240.0

1149.0

Domain

BRCT

Tgene

RFC1

chr4:39522970

chr4:39322994

ENST00000349703

1120_1124

240.0

1148.0

Motif

Nuclear localization signal

Tgene

RFC1

chr4:39522970

chr4:39322994

ENST00000381897

1120_1124

240.0

1149.0

Motif

Nuclear localization signal

Tgene

RFC1

chr4:39522970

chr4:39322994

ENST00000349703

650_657

240.0

1148.0

Nucleotide binding

ATP

Tgene

RFC1

chr4:39522970

chr4:39322994

ENST00000381897

650_657

240.0

1149.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000316423

130_132

54.0

495.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000316423

276_279

54.0

495.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000316423

89_93

54.0

495.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000501493

130_132

54.0

428.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000501493

276_279

54.0

428.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000501493

89_93

54.0

428.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000506179

130_132

54.0

495.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000506179

276_279

54.0

495.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000506179

89_93

54.0

495.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000507089

11_16

398.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000507089

130_132

398.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000507089

276_279

398.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000507089

89_93

398.0

Nucleotide binding

NAD

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000316423

129_135

54.0

495.0

Region

Allosteric switch region

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000316423

161_165

54.0

495.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000316423

220_224

54.0

495.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000316423

267_273

54.0

495.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000316423

321_325

54.0

495.0

Region

Important for formation of active hexamer structure

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000316423

338_339

54.0

495.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000316423

466_494

54.0

495.0

Region

Intrinsically disordered

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000316423

88_110

54.0

495.0

Region

Intrinsically disordered%3B important for formation of active hexamer structure

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000501493

129_135

54.0

428.0

Region

Allosteric switch region

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000501493

161_165

54.0

428.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000501493

220_224

54.0

428.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000501493

267_273

54.0

428.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000501493

321_325

54.0

428.0

Region

Important for formation of active hexamer structure

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000501493

338_339

54.0

428.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000501493

466_494

54.0

428.0

Region

Intrinsically disordered

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000501493

88_110

54.0

428.0

Region

Intrinsically disordered%3B important for formation of active hexamer structure

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000506179

129_135

54.0

495.0

Region

Allosteric switch region

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000506179

161_165

54.0

495.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000506179

220_224

54.0

495.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000506179

267_273

54.0

495.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000506179

321_325

54.0

495.0

Region

Important for formation of active hexamer structure

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000506179

338_339

54.0

495.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000506179

466_494

54.0

495.0

Region

Intrinsically disordered

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000506179

88_110

54.0

495.0

Region

Intrinsically disordered%3B important for formation of active hexamer structure

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000507089

129_135

398.0

Region

Allosteric switch region

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000507089

161_165

398.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000507089

220_224

398.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000507089

267_273

398.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000507089

321_325

398.0

Region

Important for formation of active hexamer structure

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000507089

338_339

398.0

Region

Substrate binding

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000507089

466_494

398.0

Region

Intrinsically disordered

Hgene

UGDH

chr4:39522970

chr4:39322994

ENST00000507089

88_110

398.0

Region

Intrinsically disordered%3B important for formation of active hexamer structure

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Fusion Gene Sequence for UGDH-RFC1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000316423_ENST00000349703_TCGA-CD-A48A_UGDH_chr4_39522970_-_RFC1_chr4_39322994_length(transcript)=4534nt_BP=505nt
AGTCTCCCCGCCCCTGAGCCGTGAAGGAAATAGGGACCTGGCCCTGGGCCTTGTGTAGCGGGAGGGGGAGCTAGGAAGCAGCTGAGGGCA
GAATCCAGGAGGGCCTGGCTGCGGGGGAATGAAGCCTCCGCCTTCGCAGGCAAAAGCCTTTAAATACGGGCTCAGGCCCGGGACTCAGAG
TGTAACGCGTGGCAGCCTGAGGGAGGGGCGTGCGCCGAGAGGGAGCTCAGATCGAGCGGGGCGCGGGTGGAGAAGCTGCGGCGGCGCGGC
CCGTAGGAAGGTGCTGTCCGAACGATCGGGATAGGAGCGGTCCCTGCGCTTGCTGCTGGGAAGTGGTACAATCATGTTTGAAATTAAGAA
GATCTGTTGCATCGGTGCAGGCTATGTTGGAGGACCCACATGTAGTGTCATTGCTCATATGTGTCCTGAAATCAGGGTAACGGTTGTTGA
TGTCAATGAATCAAGAATCAATGCGTGGAATTCTCCTACACTTCCTATTTATGAGGCTCGAAAGGACACAGAAGCGGGAGAAACGTTTTC
ATCTGTCCAAGCCAATTTAAGTAAAGCAGAAAAACATAAATATCCTCATAAAGTAAAAACAGCACAAGTTTCAGATGAAAGAAAGAGCTA
CAGTCCTAGGAAGCAAAGTAAATATGAAAGTTCAAAAGAATCTCAGCAACATTCCAAGTCATCAGCTGACAAAATAGGAGAAGTCTCTTC
TCCCAAGGCCAGTTCTAAGCTGGCAATTATGAAAAGAAAAGAAGAGAGCTCTTATAAAGAAATAGAGCCTGTGGCCTCAAAAAGAAAAGA
AAATGCCATTAAATTGAAAGGAGAGACAAAAACTCCTAAGAAAACCAAAAGTTCTCCAGCTAAAAAAGAGTCTGTAAGTCCTGAAGATTC
TGAAAAGAAACGCACTAATTATCAAGCTTATCGAAGCTACTTAAATCGAGAAGGTCCCAAGGCTCTGGGCTCCAAAGAAATACCAAAGGG
AGCTGAAAATTGCTTGGAAGGCCTTATATTTGTAATCACAGGCGTGCTGGAGTCTATTGAACGAGATGAGGCCAAGTCTCTAATTGAACG
TTATGGGGGAAAAGTAACAGGAAATGTCAGCAAGAAAACAAATTATCTTGTCATGGGTCGTGATAGTGGACAGTCCAAGAGTGATAAGGC
CGCAGCCTTGGGGACAAAAATTATTGATGAAGATGGCCTGTTGAATCTGATTCGGACTATGCCAGGCAAGAAATCCAAGTATGAAATAGC
AGTTGAAACTGAGATGAAGAAAGAGTCCAAACTGGAGAGAACACCCCAAAAAAATGTCCAAGGAAAAAGAAAAATTAGTCCATCTAAAAA
GGAATCAGAATCTAAAAAGAGCAGGCCGACTTCCAAAAGGGACAGTTTGGCAAAGACAATAAAAAAGGAAACAGATGTGTTTTGGAAAAG
CCTGGATTTCAAGGAGCAGGTGGCTGAGGAGACAAGTGGTGACAGCAAGGCTAGGAATTTGGCTGATGACAGCAGTGAAAACAAAGTGGA
AAATTTGCTCTGGGTGGATAAATATAAGCCAACCTCGCTCAAGACCATAATTGGACAGCAAGGTGACCAGAGCTGTGCCAACAAACTCCT
ACGCTGGCTCCGAAACTGGCAAAAGAGTTCTTCCGAAGATAAAAAACACGCAAAGTTTGGTAAATTTTCCGGCAAAGATGATGGCTCTAG
TTTTAAAGCAGCGTTGCTGTCAGGCCCTCCTGGTGTTGGCAAAACCACCACAGCTTCCCTGGTGTGTCAGGAGTTGGGATACAGCTACGT
GGAACTGAATGCAAGTGACACCCGGAGTAAGAGCAGTTTGAAGGCGATTGTTGCTGAGTCACTGAACAATACCAGCATCAAAGGCTTTTA
TTCAAATGGAGCAGCCTCTTCAGTAAGCACGAAACATGCTCTCATCATGGATGAAGTAGATGGCATGGCAGGCAATGAGGATAGGGGAGG
AATTCAGGAATTAATTGGCCTGATAAAACATACTAAAATTCCCATTATTTGTATGTGCAATGATAGAAATCATCCCAAGATTCGCTCTCT
GGTTCATTATTGTTTTGATCTTCGTTTTCAAAGACCTCGGGTTGAACAGATTAAGGGTGCTATGATGTCTATTGCATTTAAAGAAGGTTT
AAAGATTCCCCCTCCAGCTATGAATGAAATAATTTTGGGAGCCAATCAAGATATCAGACAGGTTTTACATAATCTGAGTATGTGGTGTGC
ACGAAGTAAAGCATTAACCTATGACCAGGCCAAAGCTGATTCTCACAGAGCCAAAAAGGATATCAAAATGGGCCCATTTGATGTTGCCCG
GAAAGTGTTTGCAGCTGGAGAGGAGACTGCTCACATGTCACTTGTGGACAAGTCAGATCTCTTTTTTCATGATTATTCAATAGCACCCCT
CTTCGTCCAGGAAAATTACATACACGTGAAGCCTGTAGCAGCAGGGGGTGACATGAAAAAGCACCTGATGCTTTTAAGCAGAGCAGCAGA
CAGCATATGCGATGGTGACCTAGTGGACAGCCAGATCCGGAGTAAGCAAAACTGGAGTCTTCTGCCTGCGCAGGCCATTTATGCCAGTGT
TCTTCCTGGAGAGTTGATGAGGGGGTACATGACCCAGTTTCCCACCTTCCCAAGCTGGCTGGGGAAGCACTCGTCTACAGGCAAACATGA
TCGTATTGTTCAGGACCTGGCCTTGCATATGAGTCTCAGAACTTACTCCAGCAAAAGGACTGTAAACATGGATTATCTGTCGCTTCTAAG
GGATGCACTTGTACAGCCCTTGACCTCACAAGGAGTAGACGGAGTACAGGATGTTGTTGCACTTATGGACACATATTATTTGATGAAAGA
AGACTTTGAGAATATCATGGAAATCAGCAGCTGGGGTGGCAAACCTAGTCCCTTTTCAAAGCTGGATCCCAAGGTGAAAGCAGCCTTCAC
AAGAGCTTACAATAAGGAAGCCCACCTTACTCCATACTCACTTCAAGCTATAAAGGCATCTAGACACAGCACAAGCCCATCCCTGGATTC
GGAATACAATGAAGAATTAAATGAAGATGACTCTCAATCTGATGAGAAAGACCAAGATGCTATAGAAACTGATGCCATGATCAAGAAAAA
GACAAAATCTTCAAAGCCTTCAAAACCAGAAAAAGATAAGGAGCCCAGAAAAGGAAAAGGAAAAAGTTCGAAGAAATGAAACCATTTTTC
ACTAGCGACAGCCACTTTTTACTCTCCCTCCTGACCAGTCCAGCTGGTCTAGAGAAAGCCTTGTTTTTTCCCAGAGCAACCATGTTTTAG
CATAATGGGATGACCTGGTGTCCCATTATAAATAAAGGGTGGTATGGCTAGAAGGGTATGAGCAGTAGGCTTATGTACACCTCTTATAGA
GGTTGATAGGACTGCTTGGGTCCTCCACTGTCCTCTGTCAATCTAGTTAGACGTGCTTCTGAATGACTGTAGAATTGGAACTAGAAACTA
CACCTGGGCTTTGGAGTCAGATTTTAGTTAACAATAATGAGCCTGGGAGCAGTAGTACTAAGGCGTCTTTTGTAGGCTTAAGAATTTATC
CTAATGGCCTTTATAGGACCAATGCTGATTTTTTTTAAAGGCAGTTCCTATTATGTGGTGAAATTTTGTAAATAAATGATTATACAAAAC
AGTCACCACCTAGAACTGGGTATTCTTTGTACATTGTCAGATATCTTTCAAAGTATAAATTAGGAATAAAAATGTTCCACATGATATGTG
TACAAATTCTTTTTAAGATTGTCATCTTGTACAGCAAAATATTATGTTGGTATATTACTTCCTTATTAATTTGCAAATGATTGGATTAAA
AAAGCTCACTGTATTCCTTACTAACCTGTTGTGTGAAACATAACATTGGCAGTCGAGGAGTCAGAACTCGGATTCCCAGCCTCACTCCCT
CTGTGTGTGTTGACCACGTCTCTGCTGTGAATAGGATTTCATGCAGTGGTCTGTTATGGGGCTTTGCAGCGTGGGGGGCTGCAGAAGATT
CTCAGACATTCTTATCCTTCTGGAGTCTCAACCCATCAGGTTCAGACCAGTAGGAACCAGGCTGGGTCAGGCTCTTAATTTCACTATGGT
GGGGGACAAAATGAACACTGGCTTTTGTTCACTTTGCCCCTGAGAGATCTAGTCCTGTCCTGTGATGGCTTCCACAAACCCTGTTGGAAG
TTTGGGTTATTCCTATAACTGTATGTGTTGAGTGGCCGTGAGGCTATGGACCTAGCCTGGAATTTAGATGTCTAGCTATTTTTTAATCTT
GTTGGTAAATGCTCAGAGGTCTGTGCTACCTCTGTGAGGTATATACTAAAATGAATGTAAAATAAGGATCGTATTCCCTGCTTTAAGGAA
CTGGTAGTCTTGTTTGGGTGATGAGACAAAGTTCTTGAGACATTTAAACTGTATTTACCAGTGTGAAAAATGTCATTTATGGAGATTAAT

>In-frame_ENST00000316423_ENST00000349703_TCGA-CD-A48A_UGDH_chr4_39522970_-_RFC1_chr4_39322994_length(amino acids)=971AA_start in transcript=313_stop in transcript=3228
MRLLLGSGTIMFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEARKDTEAGETFSSVQANLSKAEKHKY
PHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKK
TKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTN
YLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRD
SLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDK
KHAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSNGAASSVSTKHAL
IMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGA
NQDIRQVLHNLSMWCARSKALTYDQAKADSHRAKKDIKMGPFDVARKVFAAGEETAHMSLVDKSDLFFHDYSIAPLFVQENYIHVKPVAA
GGDMKKHLMLLSRAADSICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRT
YSSKRTVNMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWGGKPSPFSKLDPKVKAAFTRAYNKEAHLTPYSL

--------------------------------------------------------------
>In-frame_ENST00000316423_ENST00000381897_TCGA-CD-A48A_UGDH_chr4_39522970_-_RFC1_chr4_39322994_length(transcript)=4537nt_BP=505nt
AGTCTCCCCGCCCCTGAGCCGTGAAGGAAATAGGGACCTGGCCCTGGGCCTTGTGTAGCGGGAGGGGGAGCTAGGAAGCAGCTGAGGGCA
GAATCCAGGAGGGCCTGGCTGCGGGGGAATGAAGCCTCCGCCTTCGCAGGCAAAAGCCTTTAAATACGGGCTCAGGCCCGGGACTCAGAG
TGTAACGCGTGGCAGCCTGAGGGAGGGGCGTGCGCCGAGAGGGAGCTCAGATCGAGCGGGGCGCGGGTGGAGAAGCTGCGGCGGCGCGGC
CCGTAGGAAGGTGCTGTCCGAACGATCGGGATAGGAGCGGTCCCTGCGCTTGCTGCTGGGAAGTGGTACAATCATGTTTGAAATTAAGAA
GATCTGTTGCATCGGTGCAGGCTATGTTGGAGGACCCACATGTAGTGTCATTGCTCATATGTGTCCTGAAATCAGGGTAACGGTTGTTGA
TGTCAATGAATCAAGAATCAATGCGTGGAATTCTCCTACACTTCCTATTTATGAGGCTCGAAAGGACACAGAAGCGGGAGAAACGTTTTC
ATCTGTCCAAGCCAATTTAAGTAAAGCAGAAAAACATAAATATCCTCATAAAGTAAAAACAGCACAAGTTTCAGATGAAAGAAAGAGCTA
CAGTCCTAGGAAGCAAAGTAAATATGAAAGTTCAAAAGAATCTCAGCAACATTCCAAGTCATCAGCTGACAAAATAGGAGAAGTCTCTTC
TCCCAAGGCCAGTTCTAAGCTGGCAATTATGAAAAGAAAAGAAGAGAGCTCTTATAAAGAAATAGAGCCTGTGGCCTCAAAAAGAAAAGA
AAATGCCATTAAATTGAAAGGAGAGACAAAAACTCCTAAGAAAACCAAAAGTTCTCCAGCTAAAAAAGAGTCTGTAAGTCCTGAAGATTC
TGAAAAGAAACGCACTAATTATCAAGCTTATCGAAGCTACTTAAATCGAGAAGGTCCCAAGGCTCTGGGCTCCAAAGAAATACCAAAGGG
AGCTGAAAATTGCTTGGAAGGCCTTATATTTGTAATCACAGGCGTGCTGGAGTCTATTGAACGAGATGAGGCCAAGTCTCTAATTGAACG
TTATGGGGGAAAAGTAACAGGAAATGTCAGCAAGAAAACAAATTATCTTGTCATGGGTCGTGATAGTGGACAGTCCAAGAGTGATAAGGC
CGCAGCCTTGGGGACAAAAATTATTGATGAAGATGGCCTGTTGAATCTGATTCGGACTATGCCAGGCAAGAAATCCAAGTATGAAATAGC
AGTTGAAACTGAGATGAAGAAAGAGTCCAAACTGGAGAGAACACCCCAAAAAAATGTCCAAGGAAAAAGAAAAATTAGTCCATCTAAAAA
GGAATCAGAATCTAAAAAGAGCAGGCCGACTTCCAAAAGGGACAGTTTGGCAAAGACAATAAAAAAGGAAACAGATGTGTTTTGGAAAAG
CCTGGATTTCAAGGAGCAGGTGGCTGAGGAGACAAGTGGTGACAGCAAGGCTAGGAATTTGGCTGATGACAGCAGTGAAAACAAAGTGGA
AAATTTGCTCTGGGTGGATAAATATAAGCCAACCTCGCTCAAGACCATAATTGGACAGCAAGGTGACCAGAGCTGTGCCAACAAACTCCT
ACGCTGGCTCCGAAACTGGCAAAAGAGTTCTTCCGAAGATAAAAAACACGCAGCAAAGTTTGGTAAATTTTCCGGCAAAGATGATGGCTC
TAGTTTTAAAGCAGCGTTGCTGTCAGGCCCTCCTGGTGTTGGCAAAACCACCACAGCTTCCCTGGTGTGTCAGGAGTTGGGATACAGCTA
CGTGGAACTGAATGCAAGTGACACCCGGAGTAAGAGCAGTTTGAAGGCGATTGTTGCTGAGTCACTGAACAATACCAGCATCAAAGGCTT
TTATTCAAATGGAGCAGCCTCTTCAGTAAGCACGAAACATGCTCTCATCATGGATGAAGTAGATGGCATGGCAGGCAATGAGGATAGGGG
AGGAATTCAGGAATTAATTGGCCTGATAAAACATACTAAAATTCCCATTATTTGTATGTGCAATGATAGAAATCATCCCAAGATTCGCTC
TCTGGTTCATTATTGTTTTGATCTTCGTTTTCAAAGACCTCGGGTTGAACAGATTAAGGGTGCTATGATGTCTATTGCATTTAAAGAAGG
TTTAAAGATTCCCCCTCCAGCTATGAATGAAATAATTTTGGGAGCCAATCAAGATATCAGACAGGTTTTACATAATCTGAGTATGTGGTG
TGCACGAAGTAAAGCATTAACCTATGACCAGGCCAAAGCTGATTCTCACAGAGCCAAAAAGGATATCAAAATGGGCCCATTTGATGTTGC
CCGGAAAGTGTTTGCAGCTGGAGAGGAGACTGCTCACATGTCACTTGTGGACAAGTCAGATCTCTTTTTTCATGATTATTCAATAGCACC
CCTCTTCGTCCAGGAAAATTACATACACGTGAAGCCTGTAGCAGCAGGGGGTGACATGAAAAAGCACCTGATGCTTTTAAGCAGAGCAGC
AGACAGCATATGCGATGGTGACCTAGTGGACAGCCAGATCCGGAGTAAGCAAAACTGGAGTCTTCTGCCTGCGCAGGCCATTTATGCCAG
TGTTCTTCCTGGAGAGTTGATGAGGGGGTACATGACCCAGTTTCCCACCTTCCCAAGCTGGCTGGGGAAGCACTCGTCTACAGGCAAACA
TGATCGTATTGTTCAGGACCTGGCCTTGCATATGAGTCTCAGAACTTACTCCAGCAAAAGGACTGTAAACATGGATTATCTGTCGCTTCT
AAGGGATGCACTTGTACAGCCCTTGACCTCACAAGGAGTAGACGGAGTACAGGATGTTGTTGCACTTATGGACACATATTATTTGATGAA
AGAAGACTTTGAGAATATCATGGAAATCAGCAGCTGGGGTGGCAAACCTAGTCCCTTTTCAAAGCTGGATCCCAAGGTGAAAGCAGCCTT
CACAAGAGCTTACAATAAGGAAGCCCACCTTACTCCATACTCACTTCAAGCTATAAAGGCATCTAGACACAGCACAAGCCCATCCCTGGA
TTCGGAATACAATGAAGAATTAAATGAAGATGACTCTCAATCTGATGAGAAAGACCAAGATGCTATAGAAACTGATGCCATGATCAAGAA
AAAGACAAAATCTTCAAAGCCTTCAAAACCAGAAAAAGATAAGGAGCCCAGAAAAGGAAAAGGAAAAAGTTCGAAGAAATGAAACCATTT
TTCACTAGCGACAGCCACTTTTTACTCTCCCTCCTGACCAGTCCAGCTGGTCTAGAGAAAGCCTTGTTTTTTCCCAGAGCAACCATGTTT
TAGCATAATGGGATGACCTGGTGTCCCATTATAAATAAAGGGTGGTATGGCTAGAAGGGTATGAGCAGTAGGCTTATGTACACCTCTTAT
AGAGGTTGATAGGACTGCTTGGGTCCTCCACTGTCCTCTGTCAATCTAGTTAGACGTGCTTCTGAATGACTGTAGAATTGGAACTAGAAA
CTACACCTGGGCTTTGGAGTCAGATTTTAGTTAACAATAATGAGCCTGGGAGCAGTAGTACTAAGGCGTCTTTTGTAGGCTTAAGAATTT
ATCCTAATGGCCTTTATAGGACCAATGCTGATTTTTTTTAAAGGCAGTTCCTATTATGTGGTGAAATTTTGTAAATAAATGATTATACAA
AACAGTCACCACCTAGAACTGGGTATTCTTTGTACATTGTCAGATATCTTTCAAAGTATAAATTAGGAATAAAAATGTTCCACATGATAT
GTGTACAAATTCTTTTTAAGATTGTCATCTTGTACAGCAAAATATTATGTTGGTATATTACTTCCTTATTAATTTGCAAATGATTGGATT
AAAAAAGCTCACTGTATTCCTTACTAACCTGTTGTGTGAAACATAACATTGGCAGTCGAGGAGTCAGAACTCGGATTCCCAGCCTCACTC
CCTCTGTGTGTGTTGACCACGTCTCTGCTGTGAATAGGATTTCATGCAGTGGTCTGTTATGGGGCTTTGCAGCGTGGGGGGCTGCAGAAG
ATTCTCAGACATTCTTATCCTTCTGGAGTCTCAACCCATCAGGTTCAGACCAGTAGGAACCAGGCTGGGTCAGGCTCTTAATTTCACTAT
GGTGGGGGACAAAATGAACACTGGCTTTTGTTCACTTTGCCCCTGAGAGATCTAGTCCTGTCCTGTGATGGCTTCCACAAACCCTGTTGG
AAGTTTGGGTTATTCCTATAACTGTATGTGTTGAGTGGCCGTGAGGCTATGGACCTAGCCTGGAATTTAGATGTCTAGCTATTTTTTAAT
CTTGTTGGTAAATGCTCAGAGGTCTGTGCTACCTCTGTGAGGTATATACTAAAATGAATGTAAAATAAGGATCGTATTCCCTGCTTTAAG
GAACTGGTAGTCTTGTTTGGGTGATGAGACAAAGTTCTTGAGACATTTAAACTGTATTTACCAGTGTGAAAAATGTCATTTATGGAGATT

>In-frame_ENST00000316423_ENST00000381897_TCGA-CD-A48A_UGDH_chr4_39522970_-_RFC1_chr4_39322994_length(amino acids)=972AA_start in transcript=313_stop in transcript=3231
MRLLLGSGTIMFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEARKDTEAGETFSSVQANLSKAEKHKY
PHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKK
TKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTN
YLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRD
SLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDK
KHAAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSNGAASSVSTKHA
LIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILG
ANQDIRQVLHNLSMWCARSKALTYDQAKADSHRAKKDIKMGPFDVARKVFAAGEETAHMSLVDKSDLFFHDYSIAPLFVQENYIHVKPVA
AGGDMKKHLMLLSRAADSICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLR
TYSSKRTVNMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWGGKPSPFSKLDPKVKAAFTRAYNKEAHLTPYS

--------------------------------------------------------------
>In-frame_ENST00000501493_ENST00000349703_TCGA-CD-A48A_UGDH_chr4_39522970_-_RFC1_chr4_39322994_length(transcript)=4353nt_BP=324nt
GTAACGCGTGGCAGCCTGAGGGAGGGGCGTGCGCCGAGAGGGAGCTCAGATCGAGCGGGGCGCGGGTGGAGAAGCTGCGGCGGCGCGGCC
CGTAGGAAGGTGCTGTCCGAACGATCGGGATAGGAGCGGTCCCTGCGCTTGCTGCTGGGAAGTGGTACAATCATGTTTGAAATTAAGAAG
ATCTGTTGCATCGGTGCAGGCTATGTTGGAGGACCCACATGTAGTGTCATTGCTCATATGTGTCCTGAAATCAGGGTAACGGTTGTTGAT
GTCAATGAATCAAGAATCAATGCGTGGAATTCTCCTACACTTCCTATTTATGAGGCTCGAAAGGACACAGAAGCGGGAGAAACGTTTTCA
TCTGTCCAAGCCAATTTAAGTAAAGCAGAAAAACATAAATATCCTCATAAAGTAAAAACAGCACAAGTTTCAGATGAAAGAAAGAGCTAC
AGTCCTAGGAAGCAAAGTAAATATGAAAGTTCAAAAGAATCTCAGCAACATTCCAAGTCATCAGCTGACAAAATAGGAGAAGTCTCTTCT
CCCAAGGCCAGTTCTAAGCTGGCAATTATGAAAAGAAAAGAAGAGAGCTCTTATAAAGAAATAGAGCCTGTGGCCTCAAAAAGAAAAGAA
AATGCCATTAAATTGAAAGGAGAGACAAAAACTCCTAAGAAAACCAAAAGTTCTCCAGCTAAAAAAGAGTCTGTAAGTCCTGAAGATTCT
GAAAAGAAACGCACTAATTATCAAGCTTATCGAAGCTACTTAAATCGAGAAGGTCCCAAGGCTCTGGGCTCCAAAGAAATACCAAAGGGA
GCTGAAAATTGCTTGGAAGGCCTTATATTTGTAATCACAGGCGTGCTGGAGTCTATTGAACGAGATGAGGCCAAGTCTCTAATTGAACGT
TATGGGGGAAAAGTAACAGGAAATGTCAGCAAGAAAACAAATTATCTTGTCATGGGTCGTGATAGTGGACAGTCCAAGAGTGATAAGGCC
GCAGCCTTGGGGACAAAAATTATTGATGAAGATGGCCTGTTGAATCTGATTCGGACTATGCCAGGCAAGAAATCCAAGTATGAAATAGCA
GTTGAAACTGAGATGAAGAAAGAGTCCAAACTGGAGAGAACACCCCAAAAAAATGTCCAAGGAAAAAGAAAAATTAGTCCATCTAAAAAG
GAATCAGAATCTAAAAAGAGCAGGCCGACTTCCAAAAGGGACAGTTTGGCAAAGACAATAAAAAAGGAAACAGATGTGTTTTGGAAAAGC
CTGGATTTCAAGGAGCAGGTGGCTGAGGAGACAAGTGGTGACAGCAAGGCTAGGAATTTGGCTGATGACAGCAGTGAAAACAAAGTGGAA
AATTTGCTCTGGGTGGATAAATATAAGCCAACCTCGCTCAAGACCATAATTGGACAGCAAGGTGACCAGAGCTGTGCCAACAAACTCCTA
CGCTGGCTCCGAAACTGGCAAAAGAGTTCTTCCGAAGATAAAAAACACGCAAAGTTTGGTAAATTTTCCGGCAAAGATGATGGCTCTAGT
TTTAAAGCAGCGTTGCTGTCAGGCCCTCCTGGTGTTGGCAAAACCACCACAGCTTCCCTGGTGTGTCAGGAGTTGGGATACAGCTACGTG
GAACTGAATGCAAGTGACACCCGGAGTAAGAGCAGTTTGAAGGCGATTGTTGCTGAGTCACTGAACAATACCAGCATCAAAGGCTTTTAT
TCAAATGGAGCAGCCTCTTCAGTAAGCACGAAACATGCTCTCATCATGGATGAAGTAGATGGCATGGCAGGCAATGAGGATAGGGGAGGA
ATTCAGGAATTAATTGGCCTGATAAAACATACTAAAATTCCCATTATTTGTATGTGCAATGATAGAAATCATCCCAAGATTCGCTCTCTG
GTTCATTATTGTTTTGATCTTCGTTTTCAAAGACCTCGGGTTGAACAGATTAAGGGTGCTATGATGTCTATTGCATTTAAAGAAGGTTTA
AAGATTCCCCCTCCAGCTATGAATGAAATAATTTTGGGAGCCAATCAAGATATCAGACAGGTTTTACATAATCTGAGTATGTGGTGTGCA
CGAAGTAAAGCATTAACCTATGACCAGGCCAAAGCTGATTCTCACAGAGCCAAAAAGGATATCAAAATGGGCCCATTTGATGTTGCCCGG
AAAGTGTTTGCAGCTGGAGAGGAGACTGCTCACATGTCACTTGTGGACAAGTCAGATCTCTTTTTTCATGATTATTCAATAGCACCCCTC
TTCGTCCAGGAAAATTACATACACGTGAAGCCTGTAGCAGCAGGGGGTGACATGAAAAAGCACCTGATGCTTTTAAGCAGAGCAGCAGAC
AGCATATGCGATGGTGACCTAGTGGACAGCCAGATCCGGAGTAAGCAAAACTGGAGTCTTCTGCCTGCGCAGGCCATTTATGCCAGTGTT
CTTCCTGGAGAGTTGATGAGGGGGTACATGACCCAGTTTCCCACCTTCCCAAGCTGGCTGGGGAAGCACTCGTCTACAGGCAAACATGAT
CGTATTGTTCAGGACCTGGCCTTGCATATGAGTCTCAGAACTTACTCCAGCAAAAGGACTGTAAACATGGATTATCTGTCGCTTCTAAGG
GATGCACTTGTACAGCCCTTGACCTCACAAGGAGTAGACGGAGTACAGGATGTTGTTGCACTTATGGACACATATTATTTGATGAAAGAA
GACTTTGAGAATATCATGGAAATCAGCAGCTGGGGTGGCAAACCTAGTCCCTTTTCAAAGCTGGATCCCAAGGTGAAAGCAGCCTTCACA
AGAGCTTACAATAAGGAAGCCCACCTTACTCCATACTCACTTCAAGCTATAAAGGCATCTAGACACAGCACAAGCCCATCCCTGGATTCG
GAATACAATGAAGAATTAAATGAAGATGACTCTCAATCTGATGAGAAAGACCAAGATGCTATAGAAACTGATGCCATGATCAAGAAAAAG
ACAAAATCTTCAAAGCCTTCAAAACCAGAAAAAGATAAGGAGCCCAGAAAAGGAAAAGGAAAAAGTTCGAAGAAATGAAACCATTTTTCA
CTAGCGACAGCCACTTTTTACTCTCCCTCCTGACCAGTCCAGCTGGTCTAGAGAAAGCCTTGTTTTTTCCCAGAGCAACCATGTTTTAGC
ATAATGGGATGACCTGGTGTCCCATTATAAATAAAGGGTGGTATGGCTAGAAGGGTATGAGCAGTAGGCTTATGTACACCTCTTATAGAG
GTTGATAGGACTGCTTGGGTCCTCCACTGTCCTCTGTCAATCTAGTTAGACGTGCTTCTGAATGACTGTAGAATTGGAACTAGAAACTAC
ACCTGGGCTTTGGAGTCAGATTTTAGTTAACAATAATGAGCCTGGGAGCAGTAGTACTAAGGCGTCTTTTGTAGGCTTAAGAATTTATCC
TAATGGCCTTTATAGGACCAATGCTGATTTTTTTTAAAGGCAGTTCCTATTATGTGGTGAAATTTTGTAAATAAATGATTATACAAAACA
GTCACCACCTAGAACTGGGTATTCTTTGTACATTGTCAGATATCTTTCAAAGTATAAATTAGGAATAAAAATGTTCCACATGATATGTGT
ACAAATTCTTTTTAAGATTGTCATCTTGTACAGCAAAATATTATGTTGGTATATTACTTCCTTATTAATTTGCAAATGATTGGATTAAAA
AAGCTCACTGTATTCCTTACTAACCTGTTGTGTGAAACATAACATTGGCAGTCGAGGAGTCAGAACTCGGATTCCCAGCCTCACTCCCTC
TGTGTGTGTTGACCACGTCTCTGCTGTGAATAGGATTTCATGCAGTGGTCTGTTATGGGGCTTTGCAGCGTGGGGGGCTGCAGAAGATTC
TCAGACATTCTTATCCTTCTGGAGTCTCAACCCATCAGGTTCAGACCAGTAGGAACCAGGCTGGGTCAGGCTCTTAATTTCACTATGGTG
GGGGACAAAATGAACACTGGCTTTTGTTCACTTTGCCCCTGAGAGATCTAGTCCTGTCCTGTGATGGCTTCCACAAACCCTGTTGGAAGT
TTGGGTTATTCCTATAACTGTATGTGTTGAGTGGCCGTGAGGCTATGGACCTAGCCTGGAATTTAGATGTCTAGCTATTTTTTAATCTTG
TTGGTAAATGCTCAGAGGTCTGTGCTACCTCTGTGAGGTATATACTAAAATGAATGTAAAATAAGGATCGTATTCCCTGCTTTAAGGAAC
TGGTAGTCTTGTTTGGGTGATGAGACAAAGTTCTTGAGACATTTAAACTGTATTTACCAGTGTGAAAAATGTCATTTATGGAGATTAATT

>In-frame_ENST00000501493_ENST00000349703_TCGA-CD-A48A_UGDH_chr4_39522970_-_RFC1_chr4_39322994_length(amino acids)=971AA_start in transcript=132_stop in transcript=3047
MRLLLGSGTIMFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEARKDTEAGETFSSVQANLSKAEKHKY
PHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKK
TKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTN
YLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRD
SLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDK
KHAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSNGAASSVSTKHAL
IMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGA
NQDIRQVLHNLSMWCARSKALTYDQAKADSHRAKKDIKMGPFDVARKVFAAGEETAHMSLVDKSDLFFHDYSIAPLFVQENYIHVKPVAA
GGDMKKHLMLLSRAADSICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRT
YSSKRTVNMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWGGKPSPFSKLDPKVKAAFTRAYNKEAHLTPYSL

--------------------------------------------------------------
>In-frame_ENST00000501493_ENST00000381897_TCGA-CD-A48A_UGDH_chr4_39522970_-_RFC1_chr4_39322994_length(transcript)=4356nt_BP=324nt
GTAACGCGTGGCAGCCTGAGGGAGGGGCGTGCGCCGAGAGGGAGCTCAGATCGAGCGGGGCGCGGGTGGAGAAGCTGCGGCGGCGCGGCC
CGTAGGAAGGTGCTGTCCGAACGATCGGGATAGGAGCGGTCCCTGCGCTTGCTGCTGGGAAGTGGTACAATCATGTTTGAAATTAAGAAG
ATCTGTTGCATCGGTGCAGGCTATGTTGGAGGACCCACATGTAGTGTCATTGCTCATATGTGTCCTGAAATCAGGGTAACGGTTGTTGAT
GTCAATGAATCAAGAATCAATGCGTGGAATTCTCCTACACTTCCTATTTATGAGGCTCGAAAGGACACAGAAGCGGGAGAAACGTTTTCA
TCTGTCCAAGCCAATTTAAGTAAAGCAGAAAAACATAAATATCCTCATAAAGTAAAAACAGCACAAGTTTCAGATGAAAGAAAGAGCTAC
AGTCCTAGGAAGCAAAGTAAATATGAAAGTTCAAAAGAATCTCAGCAACATTCCAAGTCATCAGCTGACAAAATAGGAGAAGTCTCTTCT
CCCAAGGCCAGTTCTAAGCTGGCAATTATGAAAAGAAAAGAAGAGAGCTCTTATAAAGAAATAGAGCCTGTGGCCTCAAAAAGAAAAGAA
AATGCCATTAAATTGAAAGGAGAGACAAAAACTCCTAAGAAAACCAAAAGTTCTCCAGCTAAAAAAGAGTCTGTAAGTCCTGAAGATTCT
GAAAAGAAACGCACTAATTATCAAGCTTATCGAAGCTACTTAAATCGAGAAGGTCCCAAGGCTCTGGGCTCCAAAGAAATACCAAAGGGA
GCTGAAAATTGCTTGGAAGGCCTTATATTTGTAATCACAGGCGTGCTGGAGTCTATTGAACGAGATGAGGCCAAGTCTCTAATTGAACGT
TATGGGGGAAAAGTAACAGGAAATGTCAGCAAGAAAACAAATTATCTTGTCATGGGTCGTGATAGTGGACAGTCCAAGAGTGATAAGGCC
GCAGCCTTGGGGACAAAAATTATTGATGAAGATGGCCTGTTGAATCTGATTCGGACTATGCCAGGCAAGAAATCCAAGTATGAAATAGCA
GTTGAAACTGAGATGAAGAAAGAGTCCAAACTGGAGAGAACACCCCAAAAAAATGTCCAAGGAAAAAGAAAAATTAGTCCATCTAAAAAG
GAATCAGAATCTAAAAAGAGCAGGCCGACTTCCAAAAGGGACAGTTTGGCAAAGACAATAAAAAAGGAAACAGATGTGTTTTGGAAAAGC
CTGGATTTCAAGGAGCAGGTGGCTGAGGAGACAAGTGGTGACAGCAAGGCTAGGAATTTGGCTGATGACAGCAGTGAAAACAAAGTGGAA
AATTTGCTCTGGGTGGATAAATATAAGCCAACCTCGCTCAAGACCATAATTGGACAGCAAGGTGACCAGAGCTGTGCCAACAAACTCCTA
CGCTGGCTCCGAAACTGGCAAAAGAGTTCTTCCGAAGATAAAAAACACGCAGCAAAGTTTGGTAAATTTTCCGGCAAAGATGATGGCTCT
AGTTTTAAAGCAGCGTTGCTGTCAGGCCCTCCTGGTGTTGGCAAAACCACCACAGCTTCCCTGGTGTGTCAGGAGTTGGGATACAGCTAC
GTGGAACTGAATGCAAGTGACACCCGGAGTAAGAGCAGTTTGAAGGCGATTGTTGCTGAGTCACTGAACAATACCAGCATCAAAGGCTTT
TATTCAAATGGAGCAGCCTCTTCAGTAAGCACGAAACATGCTCTCATCATGGATGAAGTAGATGGCATGGCAGGCAATGAGGATAGGGGA
GGAATTCAGGAATTAATTGGCCTGATAAAACATACTAAAATTCCCATTATTTGTATGTGCAATGATAGAAATCATCCCAAGATTCGCTCT
CTGGTTCATTATTGTTTTGATCTTCGTTTTCAAAGACCTCGGGTTGAACAGATTAAGGGTGCTATGATGTCTATTGCATTTAAAGAAGGT
TTAAAGATTCCCCCTCCAGCTATGAATGAAATAATTTTGGGAGCCAATCAAGATATCAGACAGGTTTTACATAATCTGAGTATGTGGTGT
GCACGAAGTAAAGCATTAACCTATGACCAGGCCAAAGCTGATTCTCACAGAGCCAAAAAGGATATCAAAATGGGCCCATTTGATGTTGCC
CGGAAAGTGTTTGCAGCTGGAGAGGAGACTGCTCACATGTCACTTGTGGACAAGTCAGATCTCTTTTTTCATGATTATTCAATAGCACCC
CTCTTCGTCCAGGAAAATTACATACACGTGAAGCCTGTAGCAGCAGGGGGTGACATGAAAAAGCACCTGATGCTTTTAAGCAGAGCAGCA
GACAGCATATGCGATGGTGACCTAGTGGACAGCCAGATCCGGAGTAAGCAAAACTGGAGTCTTCTGCCTGCGCAGGCCATTTATGCCAGT
GTTCTTCCTGGAGAGTTGATGAGGGGGTACATGACCCAGTTTCCCACCTTCCCAAGCTGGCTGGGGAAGCACTCGTCTACAGGCAAACAT
GATCGTATTGTTCAGGACCTGGCCTTGCATATGAGTCTCAGAACTTACTCCAGCAAAAGGACTGTAAACATGGATTATCTGTCGCTTCTA
AGGGATGCACTTGTACAGCCCTTGACCTCACAAGGAGTAGACGGAGTACAGGATGTTGTTGCACTTATGGACACATATTATTTGATGAAA
GAAGACTTTGAGAATATCATGGAAATCAGCAGCTGGGGTGGCAAACCTAGTCCCTTTTCAAAGCTGGATCCCAAGGTGAAAGCAGCCTTC
ACAAGAGCTTACAATAAGGAAGCCCACCTTACTCCATACTCACTTCAAGCTATAAAGGCATCTAGACACAGCACAAGCCCATCCCTGGAT
TCGGAATACAATGAAGAATTAAATGAAGATGACTCTCAATCTGATGAGAAAGACCAAGATGCTATAGAAACTGATGCCATGATCAAGAAA
AAGACAAAATCTTCAAAGCCTTCAAAACCAGAAAAAGATAAGGAGCCCAGAAAAGGAAAAGGAAAAAGTTCGAAGAAATGAAACCATTTT
TCACTAGCGACAGCCACTTTTTACTCTCCCTCCTGACCAGTCCAGCTGGTCTAGAGAAAGCCTTGTTTTTTCCCAGAGCAACCATGTTTT
AGCATAATGGGATGACCTGGTGTCCCATTATAAATAAAGGGTGGTATGGCTAGAAGGGTATGAGCAGTAGGCTTATGTACACCTCTTATA
GAGGTTGATAGGACTGCTTGGGTCCTCCACTGTCCTCTGTCAATCTAGTTAGACGTGCTTCTGAATGACTGTAGAATTGGAACTAGAAAC
TACACCTGGGCTTTGGAGTCAGATTTTAGTTAACAATAATGAGCCTGGGAGCAGTAGTACTAAGGCGTCTTTTGTAGGCTTAAGAATTTA
TCCTAATGGCCTTTATAGGACCAATGCTGATTTTTTTTAAAGGCAGTTCCTATTATGTGGTGAAATTTTGTAAATAAATGATTATACAAA
ACAGTCACCACCTAGAACTGGGTATTCTTTGTACATTGTCAGATATCTTTCAAAGTATAAATTAGGAATAAAAATGTTCCACATGATATG
TGTACAAATTCTTTTTAAGATTGTCATCTTGTACAGCAAAATATTATGTTGGTATATTACTTCCTTATTAATTTGCAAATGATTGGATTA
AAAAAGCTCACTGTATTCCTTACTAACCTGTTGTGTGAAACATAACATTGGCAGTCGAGGAGTCAGAACTCGGATTCCCAGCCTCACTCC
CTCTGTGTGTGTTGACCACGTCTCTGCTGTGAATAGGATTTCATGCAGTGGTCTGTTATGGGGCTTTGCAGCGTGGGGGGCTGCAGAAGA
TTCTCAGACATTCTTATCCTTCTGGAGTCTCAACCCATCAGGTTCAGACCAGTAGGAACCAGGCTGGGTCAGGCTCTTAATTTCACTATG
GTGGGGGACAAAATGAACACTGGCTTTTGTTCACTTTGCCCCTGAGAGATCTAGTCCTGTCCTGTGATGGCTTCCACAAACCCTGTTGGA
AGTTTGGGTTATTCCTATAACTGTATGTGTTGAGTGGCCGTGAGGCTATGGACCTAGCCTGGAATTTAGATGTCTAGCTATTTTTTAATC
TTGTTGGTAAATGCTCAGAGGTCTGTGCTACCTCTGTGAGGTATATACTAAAATGAATGTAAAATAAGGATCGTATTCCCTGCTTTAAGG
AACTGGTAGTCTTGTTTGGGTGATGAGACAAAGTTCTTGAGACATTTAAACTGTATTTACCAGTGTGAAAAATGTCATTTATGGAGATTA

>In-frame_ENST00000501493_ENST00000381897_TCGA-CD-A48A_UGDH_chr4_39522970_-_RFC1_chr4_39322994_length(amino acids)=972AA_start in transcript=132_stop in transcript=3050
MRLLLGSGTIMFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEARKDTEAGETFSSVQANLSKAEKHKY
PHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKK
TKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTN
YLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRD
SLAKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDK
KHAAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSNGAASSVSTKHA
LIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILG
ANQDIRQVLHNLSMWCARSKALTYDQAKADSHRAKKDIKMGPFDVARKVFAAGEETAHMSLVDKSDLFFHDYSIAPLFVQENYIHVKPVA
AGGDMKKHLMLLSRAADSICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLR
TYSSKRTVNMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWGGKPSPFSKLDPKVKAAFTRAYNKEAHLTPYS

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Fusion Gene PPI Analysis for UGDH-RFC1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for UGDH-RFC1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for UGDH-RFC1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	UGDH	C0023903	Liver neoplasms	1	CTD_human
Hgene	UGDH	C0345904	Malignant neoplasm of liver	1	CTD_human
Tgene	RFC1	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Tgene	RFC1	C0007102	Malignant tumor of colon	1	CTD_human
Tgene	RFC1	C0007758	Cerebellar Ataxia	1	CTD_human
Tgene	RFC1	C0009375	Colonic Neoplasms	1	CTD_human
Tgene	RFC1	C0011195	Dejerine-Sottas Disease (disorder)	1	CTD_human
Tgene	RFC1	C0019816	Hereditary, Type VII, Motor and Sensory Neuropathy	1	CTD_human
Tgene	RFC1	C0027888	Hereditary Motor and Sensory Neuropathies	1	CTD_human
Tgene	RFC1	C0029463	Osteosarcoma	1	CTD_human
Tgene	RFC1	C0234162	Cerebellar Dysmetria	1	CTD_human
Tgene	RFC1	C0234357	Adiadochokinesis	1	CTD_human
Tgene	RFC1	C0750994	Cerebellar Hemiataxia	1	CTD_human
Tgene	RFC1	C3668822	Hypermetria (finding)	1	CTD_human
Tgene	RFC1	C4255193	Bilateral Vestibulopathy	1	CTD_human
Tgene	RFC1	C4285893	Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome	1	ORPHANET