FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:UGP2-PLEKHM3 (FusionGDB2 ID:95993)

Fusion Gene Summary for UGP2-PLEKHM3

check button Fusion gene summary
Fusion gene informationFusion gene name: UGP2-PLEKHM3
Fusion gene ID: 95993
HgeneTgene
Gene symbol

UGP2

PLEKHM3

Gene ID

7360

389072

Gene nameUDP-glucose pyrophosphorylase 2pleckstrin homology domain containing M3
SynonymsEIEE83|SVUGP2|UDPG|UDPGP|UDPGP2|UGP1|UGPP1|UGPP2|pHC379DAPR|PLEKHM1L
Cytomap

2p15

2q33.3

Type of geneprotein-codingprotein-coding
DescriptionUTP--glucose-1-phosphate uridylyltransferaseUDP-glucose diphosphorylaseUDP-glucose pyrophosphorylase 1UGPase 2UTP--glucose-1-phosphate uridylyltransferase 2UTP-glucose-1-phosphate uridyltransferaseUridyl diphosphate glucose pyrophosphorylase-1testipleckstrin homology domain-containing family M member 3PH domain-containing family M member 3differentiation associated protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000394417, ENST00000467648, 
ENST00000487469, ENST00000337130, 
ENST00000445915, 		ENST00000427836, 
ENST00000389247, ENST00000457206, 
Fusion gene scores* DoF score6 X 4 X 4=967 X 4 X 5=140
# samples 66
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UGP2 [Title/Abstract] AND PLEKHM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUGP2(64085070)-PLEKHM3(208795843), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across UGP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PLEKHM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-8083-01AUGP2chr2

64085070

+PLEKHM3chr2

208795843

-
ChimerDB4LUSCTCGA-56-8083UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
ChimerDB4LUSCTCGA-56-8083-01AUGP2chr2

64085070

-PLEKHM3chr2

208795843

-


Top

Fusion Gene ORF analysis for UGP2-PLEKHM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000394417ENST00000427836UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000394417ENST00000389247UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000394417ENST00000457206UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000467648ENST00000427836UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000467648ENST00000389247UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000467648ENST00000457206UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
intron-3CDSENST00000487469ENST00000427836UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
intron-3CDSENST00000487469ENST00000389247UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
intron-3CDSENST00000487469ENST00000457206UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000337130ENST00000427836UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000337130ENST00000389247UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000337130ENST00000457206UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000445915ENST00000427836UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000445915ENST00000389247UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000445915ENST00000457206UGP2chr2

64085070

+PLEKHM3chr2

208795843

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394417UGP2chr264085070+ENST00000427836PLEKHM3chr2208795843-11395292741122282
ENST00000394417UGP2chr264085070+ENST00000389247PLEKHM3chr2208795843-991529274990239
ENST00000394417UGP2chr264085070+ENST00000457206PLEKHM3chr2208795843-2098529274855193
ENST00000467648UGP2chr264085070+ENST00000427836PLEKHM3chr2208795843-11715613391154271
ENST00000467648UGP2chr264085070+ENST00000389247PLEKHM3chr2208795843-10235613391022227
ENST00000467648UGP2chr264085070+ENST00000457206PLEKHM3chr2208795843-2130561339887182
ENST00000337130UGP2chr264085070+ENST00000427836PLEKHM3chr2208795843-13417314761324282
ENST00000337130UGP2chr264085070+ENST00000389247PLEKHM3chr2208795843-11937314761192239
ENST00000337130UGP2chr264085070+ENST00000457206PLEKHM3chr2208795843-23007314761057193
ENST00000445915UGP2chr264085070+ENST00000427836PLEKHM3chr2208795843-95934967942291
ENST00000445915UGP2chr264085070+ENST00000389247PLEKHM3chr2208795843-81134967810248
ENST00000445915UGP2chr264085070+ENST00000457206PLEKHM3chr2208795843-191834967675202

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394417ENST00000427836UGP2chr264085070+PLEKHM3chr2208795843-0.0073742640.9926258
ENST00000394417ENST00000389247UGP2chr264085070+PLEKHM3chr2208795843-0.0043918610.99560815
ENST00000394417ENST00000457206UGP2chr264085070+PLEKHM3chr2208795843-0.0047188670.99528116
ENST00000467648ENST00000427836UGP2chr264085070+PLEKHM3chr2208795843-0.0080747910.9919252
ENST00000467648ENST00000389247UGP2chr264085070+PLEKHM3chr2208795843-0.0049653120.9950347
ENST00000467648ENST00000457206UGP2chr264085070+PLEKHM3chr2208795843-0.0050893550.99491066
ENST00000337130ENST00000427836UGP2chr264085070+PLEKHM3chr2208795843-0.0044850130.9955149
ENST00000337130ENST00000389247UGP2chr264085070+PLEKHM3chr2208795843-0.0024499770.9975501
ENST00000337130ENST00000457206UGP2chr264085070+PLEKHM3chr2208795843-0.0033484390.9966516
ENST00000445915ENST00000427836UGP2chr264085070+PLEKHM3chr2208795843-0.0091872110.9908127
ENST00000445915ENST00000389247UGP2chr264085070+PLEKHM3chr2208795843-0.0034012270.9965988
ENST00000445915ENST00000457206UGP2chr264085070+PLEKHM3chr2208795843-0.0035567480.9964432

Top

Fusion Genomic Features for UGP2-PLEKHM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for UGP2-PLEKHM3


check button Go to

FGviewer for the breakpoints of chr2:64085070-chr2:208795843

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000038924738669_722564.0718.0Zinc fingerNote=Phorbol-ester/DAG-type
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000042783638669_722564.0762.0Zinc fingerNote=Phorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUGP2chr2:64085070chr2:208795843ENST00000337130+310113_11685.0509.0RegionUTP binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000337130+310115_11685.0509.0RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000337130+310251_25385.0509.0RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000337130+310457_50885.0509.0RegionNote=Oligomerization
HgeneUGP2chr2:64085070chr2:208795843ENST00000394417+310113_11674.0498.0RegionUTP binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000394417+310115_11674.0498.0RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000394417+310251_25374.0498.0RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000394417+310457_50874.0498.0RegionNote=Oligomerization
HgeneUGP2chr2:64085070chr2:208795843ENST00000467648+411113_11674.0498.0RegionUTP binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000467648+411115_11674.0498.0RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000467648+411251_25374.0498.0RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000467648+411457_50874.0498.0RegionNote=Oligomerization
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000038924738169_175564.0718.0Compositional biasNote=Poly-Gln
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000042783638169_175564.0762.0Compositional biasNote=Poly-Gln
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000038924738211_308564.0718.0DomainPH 1
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000038924738361_456564.0718.0DomainPH 2
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000042783638211_308564.0762.0DomainPH 1
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000042783638361_456564.0762.0DomainPH 2


Top

Fusion Gene Sequence for UGP2-PLEKHM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000394417_ENST00000427836_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(transcript)=1139nt_BP=529nt
CTGTCGGTCCGTGCGGCAGGGACATTTCCGCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCT
GTGGGTGTCGGGAGCCGGCTGACGGGTGGACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGT
GAGGGAAGAGAGAGAGAGAGAAGGGCGCCTCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTC
CCAGCTGCTAAAGGAAGAGGAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGGTGTCGAAGCA
GGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGCTGTACCACCACGCAGAGCCGCT
GGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAGCGGTGGCAGAGGATCTCCGCCG
CAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGGTAATAGAGGGAAAGCTGGCTCC
ATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGTAGCCAGAAGGGGTTCATCTGTGAAATCTGTAA
CAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGGTGTGAAAGCTGTGGAGCCGTTTTCCATTCTGAATGCAAAGAAAA
GTCTGTCCCCTGCCCGAGGTGTGTTCGCCGAGAGCTGCAGAAGAAGCAGAAGTCTTTCTGGCAGAGACTGAACATGGACGAGAGTCTAGA

>In-frame_ENST00000394417_ENST00000427836_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(amino acids)=282AA_start in transcript=274_stop in transcript=1122
MLKEEEDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPF
LGKVIKFATSHVYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEE

--------------------------------------------------------------
>In-frame_ENST00000394417_ENST00000389247_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(transcript)=991nt_BP=529nt
CTGTCGGTCCGTGCGGCAGGGACATTTCCGCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCT
GTGGGTGTCGGGAGCCGGCTGACGGGTGGACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGT
GAGGGAAGAGAGAGAGAGAGAAGGGCGCCTCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTC
CCAGCTGCTAAAGGAAGAGGAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGGTGTCGAAGCA
GGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGCTGTACCACCACGCAGAGCCGCT
GGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAGCGGTGGCAGAGGATCTCCGCCG
CAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGGTAATAGAGGGAAAGCTGGCTCC
ATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGTAGCCAGAAGGGGTTCATCTGTGAAATCTGTAA
CAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGATTCGGAGACCCATATGCAGATTTATTACAAGGATATGTGGCCTG

>In-frame_ENST00000394417_ENST00000389247_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(amino acids)=239AA_start in transcript=274_stop in transcript=990
MLKEEEDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPF

--------------------------------------------------------------
>In-frame_ENST00000394417_ENST00000457206_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(transcript)=2098nt_BP=529nt
CTGTCGGTCCGTGCGGCAGGGACATTTCCGCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCT
GTGGGTGTCGGGAGCCGGCTGACGGGTGGACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGT
GAGGGAAGAGAGAGAGAGAGAAGGGCGCCTCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTC
CCAGCTGCTAAAGGAAGAGGAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGGTGTCGAAGCA
GGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGCTGTACCACCACGCAGAGCCGCT
GGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAGCGGTGGCAGAGGATCTCCGCCG
CAGAAATGACCAGCAGCATGCATTAGTCATGTTAAATGTTTTTGGAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTAT
TCACTTGCCGACCTGCAGCAGACCCAGGCACTACAGCCAAATCTAACCTGATCCACAGATGATTGAAGGATCGGGGGAGCTCGGCACGGG
ATGTGGCAGCAAATGTGCGGCACTAAGGACAAAGTCACTGCCTTTTGTGGAAGCCAGATCAGAAAGATGACTGTGTGTTGTGAGTGGTGG
ATAGAGAGCCCTGTTGCCCAGGTGAGAAGGAGCTCAGTTGAGATAAGGATTCCAGGAGCCAACTCGAGCCCCTCAGGTAGAGACAACAAT
ACCGGTTGAGGCTGCAGCTGTGGAGTTGGATGGTGTTTAGTCAGTGCTGAAATCACTTTCCTGGGAGTCCCTTGGCATGCAGTCATCTGA
GTGCTGTTGTTGTTGTTGGGTTTTTGTTGTTTCCTATTTTAAAAGAGTAATCATAATACTGACGAAGTGAGGGCCTGTTTTCAAAGAACA
TTTACTTAAAGATATAGAGTAAGGTTAGCATCGGTCTTGCCAGTGGTAGAAACCTATGCCACCAACAGCCATCATGAAAGGGCCCCAGGA
GTCTTTCTGGTTCTTCATTTCTATTCAGTTTGATTCAACAAGTGTGTATTGATTGAATGCTTTCTGTGTGCCAATCATTGAGCTAGCCAC
AGAGGAGGCAAAGGTGATTAAGCCACAATTCCTTCCCTCACTGAGCTCACAGTCTGATGAGAGAGGCAGATAGGCATTGTTGAAGTCAGC
GGAGTTGAACCTAGGGTACTTGGGGAATACATCTGACCAAGTGTGTGGCAGATTGTATTTTGCAAAAATAGCTGCAACAGTATCTTCCAT
CCCACATGTCTTTCTTACACTGTGACTTTGATGCTCCTCCTATTCAGTAGTGAGATCTGTGTTCCTTCTCCCCGAATTTGGGCAGGTCTG
TGACTATGGAAGTGATGCCATGTGATTTCCAAAGCCAAGTCATAAAAGGTGATATAGCTCCAACCTGGTGCTGTCTGGAGATGCTCACTC
ATGGCAACCCAGTGGCCATGTTGTAAGGAAGTCCAGATTAGCCCTCATAGAACAACCACATGAACAGGCCTCATATGGTAGTTGTTCTAG
CTGGCAGCGATCATCAGCCACCAGAGAGATGAGTGAAGACAGCCCCACATGATTCCAGCTGCTAGCCTTCAAGTCTTCTCACCTAGGCTA
GAGATGAGGCTGCAGATATTATGGAGCAGAAACAAACCATCTCCACAGTGTCCTTCCTGGAGTCCTGACCGACCGACAAAATGTGTGAGC

>In-frame_ENST00000394417_ENST00000457206_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(amino acids)=193AA_start in transcript=274_stop in transcript=855
MLKEEEDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRNDQQHALVMLNVFGEFSPENTSFNRSTCIH

--------------------------------------------------------------
>In-frame_ENST00000467648_ENST00000427836_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(transcript)=1171nt_BP=561nt
GCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCTGTGGGTGTCGGGAGCCGGCTGACGGGTGG
ACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGTGAGGGAAGAGAGAGAGAGAGAAGGGCGCC
TCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTCCCAGCTGCTAAAGGAAGAGGAAGGTACCT
GTGCGTGCACGCAGACGGGAAGGGCTGGGGAAGCGGGAGGACTGAGAAAAGCCGGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCT
CAGTTCCAAGAAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTT
GAGCACACCAAAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATC
CAGAGACCCCCTGAAGATTCGGTGTCGAAGCAGGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAG
AACGCCATGCTGTACCACCACGCAGAGCCGCTGGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGC
TGCCGGGCAGCGGTGGCAGAGGATCTCCGCCGCAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGAC
CTGCAGCAGGTAATAGAGGGAAAGCTGGCTCCATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGT
AGCCAGAAGGGGTTCATCTGTGAAATCTGTAACAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGGTGTGAAAGCTGT
GGAGCCGTTTTCCATTCTGAATGCAAAGAAAAGTCTGTCCCCTGCCCGAGGTGTGTTCGCCGAGAGCTGCAGAAGAAGCAGAAGTCTTTC
TGGCAGAGACTGAACATGGACGAGAGTCTAGAGGAGGCTTGCACCATGTTCGAGCTGTCCTACCAGAACACCTGACTCCAGCCGACCCGA

>In-frame_ENST00000467648_ENST00000427836_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(amino acids)=271AA_start in transcript=339_stop in transcript=1154
MSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQAKEFLEYVYEEP
LIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPFLGKVIKFATSH
VYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEEACTMFELSYQN

--------------------------------------------------------------
>In-frame_ENST00000467648_ENST00000389247_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(transcript)=1023nt_BP=561nt
GCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCTGTGGGTGTCGGGAGCCGGCTGACGGGTGG
ACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGTGAGGGAAGAGAGAGAGAGAGAAGGGCGCC
TCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTCCCAGCTGCTAAAGGAAGAGGAAGGTACCT
GTGCGTGCACGCAGACGGGAAGGGCTGGGGAAGCGGGAGGACTGAGAAAAGCCGGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCT
CAGTTCCAAGAAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTT
GAGCACACCAAAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATC
CAGAGACCCCCTGAAGATTCGGTGTCGAAGCAGGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAG
AACGCCATGCTGTACCACCACGCAGAGCCGCTGGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGC
TGCCGGGCAGCGGTGGCAGAGGATCTCCGCCGCAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGAC
CTGCAGCAGGTAATAGAGGGAAAGCTGGCTCCATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGT
AGCCAGAAGGGGTTCATCTGTGAAATCTGTAACAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGATTCGGAGACCCA

>In-frame_ENST00000467648_ENST00000389247_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(amino acids)=227AA_start in transcript=339_stop in transcript=1022
MSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQAKEFLEYVYEEP
LIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPFLGKVIKFATSH

--------------------------------------------------------------
>In-frame_ENST00000467648_ENST00000457206_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(transcript)=2130nt_BP=561nt
GCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCTGTGGGTGTCGGGAGCCGGCTGACGGGTGG
ACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGTGAGGGAAGAGAGAGAGAGAGAAGGGCGCC
TCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTCCCAGCTGCTAAAGGAAGAGGAAGGTACCT
GTGCGTGCACGCAGACGGGAAGGGCTGGGGAAGCGGGAGGACTGAGAAAAGCCGGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCT
CAGTTCCAAGAAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTT
GAGCACACCAAAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATC
CAGAGACCCCCTGAAGATTCGGTGTCGAAGCAGGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAG
AACGCCATGCTGTACCACCACGCAGAGCCGCTGGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGC
TGCCGGGCAGCGGTGGCAGAGGATCTCCGCCGCAGAAATGACCAGCAGCATGCATTAGTCATGTTAAATGTTTTTGGAGAATTTTCCCCA
GAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGACCCAGGCACTACAGCCAAATCTAACCTGATCCACAG
ATGATTGAAGGATCGGGGGAGCTCGGCACGGGATGTGGCAGCAAATGTGCGGCACTAAGGACAAAGTCACTGCCTTTTGTGGAAGCCAGA
TCAGAAAGATGACTGTGTGTTGTGAGTGGTGGATAGAGAGCCCTGTTGCCCAGGTGAGAAGGAGCTCAGTTGAGATAAGGATTCCAGGAG
CCAACTCGAGCCCCTCAGGTAGAGACAACAATACCGGTTGAGGCTGCAGCTGTGGAGTTGGATGGTGTTTAGTCAGTGCTGAAATCACTT
TCCTGGGAGTCCCTTGGCATGCAGTCATCTGAGTGCTGTTGTTGTTGTTGGGTTTTTGTTGTTTCCTATTTTAAAAGAGTAATCATAATA
CTGACGAAGTGAGGGCCTGTTTTCAAAGAACATTTACTTAAAGATATAGAGTAAGGTTAGCATCGGTCTTGCCAGTGGTAGAAACCTATG
CCACCAACAGCCATCATGAAAGGGCCCCAGGAGTCTTTCTGGTTCTTCATTTCTATTCAGTTTGATTCAACAAGTGTGTATTGATTGAAT
GCTTTCTGTGTGCCAATCATTGAGCTAGCCACAGAGGAGGCAAAGGTGATTAAGCCACAATTCCTTCCCTCACTGAGCTCACAGTCTGAT
GAGAGAGGCAGATAGGCATTGTTGAAGTCAGCGGAGTTGAACCTAGGGTACTTGGGGAATACATCTGACCAAGTGTGTGGCAGATTGTAT
TTTGCAAAAATAGCTGCAACAGTATCTTCCATCCCACATGTCTTTCTTACACTGTGACTTTGATGCTCCTCCTATTCAGTAGTGAGATCT
GTGTTCCTTCTCCCCGAATTTGGGCAGGTCTGTGACTATGGAAGTGATGCCATGTGATTTCCAAAGCCAAGTCATAAAAGGTGATATAGC
TCCAACCTGGTGCTGTCTGGAGATGCTCACTCATGGCAACCCAGTGGCCATGTTGTAAGGAAGTCCAGATTAGCCCTCATAGAACAACCA
CATGAACAGGCCTCATATGGTAGTTGTTCTAGCTGGCAGCGATCATCAGCCACCAGAGAGATGAGTGAAGACAGCCCCACATGATTCCAG
CTGCTAGCCTTCAAGTCTTCTCACCTAGGCTAGAGATGAGGCTGCAGATATTATGGAGCAGAAACAAACCATCTCCACAGTGTCCTTCCT

>In-frame_ENST00000467648_ENST00000457206_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(amino acids)=182AA_start in transcript=339_stop in transcript=887
MSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQAKEFLEYVYEEP
LIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRNDQQHALVMLNVFGEFSPENTSFNRSTCIHLPTCSRPRHYS

--------------------------------------------------------------
>In-frame_ENST00000337130_ENST00000427836_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(transcript)=1341nt_BP=731nt
GGTTTTCGGGGGAGGCGTTTGGGGCCTGGACGGCGGCGCGGGGAGGGGGCAGCTAGGGGCGCGGCCTGCCAGTGCCTCCTGCAGTACAGC
CCTGGAGGGCGTGGGGACTTGGGGGCGGTGAAATAGCCGCTGTAGGTCCGCCTCTTTCATTGAAGAAATTTAAGTTCGTGTGGTTTTACC
TTTTCCGGGAGTCTCCAGCTGGCCCTCATTTGTGTCCGGAGCTCAGGAGTTCCCAAACCGACTCAGTCGCACCAAGTTTCCGTCTTTTGG
AATTGGGGAAGGAGTTTCTTTCTTTCTTTTCTTTTTTCTTGAGCCAGTTTTAATCGCTTTGAATAAATACTCCCTTAAGTAGTTAAATAT
AGGAGGAGAAAGAATACATCGGTTGTTAAAGCAGGAGAGGAAGAGAGACCTGCCCTGTAGCGTGACTCCTCTAGAAAAAAAAAAAAAAAG
CCGGAGTATTTTACTAAGCCCCTAAAATGTCGAGATTTGTACAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAG
AAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCA
AAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCC
CTGAAGATTCGGTGTCGAAGCAGGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGC
TGTACCACCACGCAGAGCCGCTGGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAG
CGGTGGCAGAGGATCTCCGCCGCAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGG
TAATAGAGGGAAAGCTGGCTCCATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGTAGCCAGAAGG
GGTTCATCTGTGAAATCTGTAACAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGGTGTGAAAGCTGTGGAGCCGTTT
TCCATTCTGAATGCAAAGAAAAGTCTGTCCCCTGCCCGAGGTGTGTTCGCCGAGAGCTGCAGAAGAAGCAGAAGTCTTTCTGGCAGAGAC

>In-frame_ENST00000337130_ENST00000427836_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(amino acids)=282AA_start in transcript=476_stop in transcript=1324
MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPF
LGKVIKFATSHVYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEE

--------------------------------------------------------------
>In-frame_ENST00000337130_ENST00000389247_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(transcript)=1193nt_BP=731nt
GGTTTTCGGGGGAGGCGTTTGGGGCCTGGACGGCGGCGCGGGGAGGGGGCAGCTAGGGGCGCGGCCTGCCAGTGCCTCCTGCAGTACAGC
CCTGGAGGGCGTGGGGACTTGGGGGCGGTGAAATAGCCGCTGTAGGTCCGCCTCTTTCATTGAAGAAATTTAAGTTCGTGTGGTTTTACC
TTTTCCGGGAGTCTCCAGCTGGCCCTCATTTGTGTCCGGAGCTCAGGAGTTCCCAAACCGACTCAGTCGCACCAAGTTTCCGTCTTTTGG
AATTGGGGAAGGAGTTTCTTTCTTTCTTTTCTTTTTTCTTGAGCCAGTTTTAATCGCTTTGAATAAATACTCCCTTAAGTAGTTAAATAT
AGGAGGAGAAAGAATACATCGGTTGTTAAAGCAGGAGAGGAAGAGAGACCTGCCCTGTAGCGTGACTCCTCTAGAAAAAAAAAAAAAAAG
CCGGAGTATTTTACTAAGCCCCTAAAATGTCGAGATTTGTACAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAG
AAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCA
AAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCC
CTGAAGATTCGGTGTCGAAGCAGGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGC
TGTACCACCACGCAGAGCCGCTGGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAG
CGGTGGCAGAGGATCTCCGCCGCAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGG
TAATAGAGGGAAAGCTGGCTCCATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGTAGCCAGAAGG
GGTTCATCTGTGAAATCTGTAACAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGATTCGGAGACCCATATGCAGATT

>In-frame_ENST00000337130_ENST00000389247_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(amino acids)=239AA_start in transcript=476_stop in transcript=1192
MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPF

--------------------------------------------------------------
>In-frame_ENST00000337130_ENST00000457206_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(transcript)=2300nt_BP=731nt
GGTTTTCGGGGGAGGCGTTTGGGGCCTGGACGGCGGCGCGGGGAGGGGGCAGCTAGGGGCGCGGCCTGCCAGTGCCTCCTGCAGTACAGC
CCTGGAGGGCGTGGGGACTTGGGGGCGGTGAAATAGCCGCTGTAGGTCCGCCTCTTTCATTGAAGAAATTTAAGTTCGTGTGGTTTTACC
TTTTCCGGGAGTCTCCAGCTGGCCCTCATTTGTGTCCGGAGCTCAGGAGTTCCCAAACCGACTCAGTCGCACCAAGTTTCCGTCTTTTGG
AATTGGGGAAGGAGTTTCTTTCTTTCTTTTCTTTTTTCTTGAGCCAGTTTTAATCGCTTTGAATAAATACTCCCTTAAGTAGTTAAATAT
AGGAGGAGAAAGAATACATCGGTTGTTAAAGCAGGAGAGGAAGAGAGACCTGCCCTGTAGCGTGACTCCTCTAGAAAAAAAAAAAAAAAG
CCGGAGTATTTTACTAAGCCCCTAAAATGTCGAGATTTGTACAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAG
AAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCA
AAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCC
CTGAAGATTCGGTGTCGAAGCAGGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGC
TGTACCACCACGCAGAGCCGCTGGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAG
CGGTGGCAGAGGATCTCCGCCGCAGAAATGACCAGCAGCATGCATTAGTCATGTTAAATGTTTTTGGAGAATTTTCCCCAGAGAATACCT
CCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGACCCAGGCACTACAGCCAAATCTAACCTGATCCACAGATGATTGAAG
GATCGGGGGAGCTCGGCACGGGATGTGGCAGCAAATGTGCGGCACTAAGGACAAAGTCACTGCCTTTTGTGGAAGCCAGATCAGAAAGAT
GACTGTGTGTTGTGAGTGGTGGATAGAGAGCCCTGTTGCCCAGGTGAGAAGGAGCTCAGTTGAGATAAGGATTCCAGGAGCCAACTCGAG
CCCCTCAGGTAGAGACAACAATACCGGTTGAGGCTGCAGCTGTGGAGTTGGATGGTGTTTAGTCAGTGCTGAAATCACTTTCCTGGGAGT
CCCTTGGCATGCAGTCATCTGAGTGCTGTTGTTGTTGTTGGGTTTTTGTTGTTTCCTATTTTAAAAGAGTAATCATAATACTGACGAAGT
GAGGGCCTGTTTTCAAAGAACATTTACTTAAAGATATAGAGTAAGGTTAGCATCGGTCTTGCCAGTGGTAGAAACCTATGCCACCAACAG
CCATCATGAAAGGGCCCCAGGAGTCTTTCTGGTTCTTCATTTCTATTCAGTTTGATTCAACAAGTGTGTATTGATTGAATGCTTTCTGTG
TGCCAATCATTGAGCTAGCCACAGAGGAGGCAAAGGTGATTAAGCCACAATTCCTTCCCTCACTGAGCTCACAGTCTGATGAGAGAGGCA
GATAGGCATTGTTGAAGTCAGCGGAGTTGAACCTAGGGTACTTGGGGAATACATCTGACCAAGTGTGTGGCAGATTGTATTTTGCAAAAA
TAGCTGCAACAGTATCTTCCATCCCACATGTCTTTCTTACACTGTGACTTTGATGCTCCTCCTATTCAGTAGTGAGATCTGTGTTCCTTC
TCCCCGAATTTGGGCAGGTCTGTGACTATGGAAGTGATGCCATGTGATTTCCAAAGCCAAGTCATAAAAGGTGATATAGCTCCAACCTGG
TGCTGTCTGGAGATGCTCACTCATGGCAACCCAGTGGCCATGTTGTAAGGAAGTCCAGATTAGCCCTCATAGAACAACCACATGAACAGG
CCTCATATGGTAGTTGTTCTAGCTGGCAGCGATCATCAGCCACCAGAGAGATGAGTGAAGACAGCCCCACATGATTCCAGCTGCTAGCCT
TCAAGTCTTCTCACCTAGGCTAGAGATGAGGCTGCAGATATTATGGAGCAGAAACAAACCATCTCCACAGTGTCCTTCCTGGAGTCCTGA

>In-frame_ENST00000337130_ENST00000457206_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(amino acids)=193AA_start in transcript=476_stop in transcript=1057
MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRNDQQHALVMLNVFGEFSPENTSFNRSTCIH

--------------------------------------------------------------
>In-frame_ENST00000445915_ENST00000427836_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(transcript)=959nt_BP=349nt
CTTTTCGTTGAATTGTCATCTGAGCTGCCTTGAGCTGCTGGGTTGACGTTCCAGACGCGTATAATTTATGCTCCTGTACCCTGCTGGGTT
TAGTTTTGCCTCCCTGAAATCAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGGTGTCGAAGCA
GGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGCTGTACCACCACGCAGAGCCGCT
GGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAGCGGTGGCAGAGGATCTCCGCCG
CAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGGTAATAGAGGGAAAGCTGGCTCC
ATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGTAGCCAGAAGGGGTTCATCTGTGAAATCTGTAA
CAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGGTGTGAAAGCTGTGGAGCCGTTTTCCATTCTGAATGCAAAGAAAA
GTCTGTCCCCTGCCCGAGGTGTGTTCGCCGAGAGCTGCAGAAGAAGCAGAAGTCTTTCTGGCAGAGACTGAACATGGACGAGAGTCTAGA

>In-frame_ENST00000445915_ENST00000427836_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(amino acids)=291AA_start in transcript=67_stop in transcript=942
MLLYPAGFSFASLKSDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRP
PEDSVSKQAKEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQ
VIEGKLAPFLGKVIKFATSHVYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQR

--------------------------------------------------------------
>In-frame_ENST00000445915_ENST00000389247_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(transcript)=811nt_BP=349nt
CTTTTCGTTGAATTGTCATCTGAGCTGCCTTGAGCTGCTGGGTTGACGTTCCAGACGCGTATAATTTATGCTCCTGTACCCTGCTGGGTT
TAGTTTTGCCTCCCTGAAATCAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGGTGTCGAAGCA
GGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGCTGTACCACCACGCAGAGCCGCT
GGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAGCGGTGGCAGAGGATCTCCGCCG
CAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGGTAATAGAGGGAAAGCTGGCTCC
ATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGTAGCCAGAAGGGGTTCATCTGTGAAATCTGTAA
CAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGATTCGGAGACCCATATGCAGATTTATTACAAGGATATGTGGCCTG

>In-frame_ENST00000445915_ENST00000389247_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(amino acids)=248AA_start in transcript=67_stop in transcript=810
MLLYPAGFSFASLKSDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRP
PEDSVSKQAKEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQ

--------------------------------------------------------------
>In-frame_ENST00000445915_ENST00000457206_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(transcript)=1918nt_BP=349nt
CTTTTCGTTGAATTGTCATCTGAGCTGCCTTGAGCTGCTGGGTTGACGTTCCAGACGCGTATAATTTATGCTCCTGTACCCTGCTGGGTT
TAGTTTTGCCTCCCTGAAATCAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGGTGTCGAAGCA
GGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGCTGTACCACCACGCAGAGCCGCT
GGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAGCGGTGGCAGAGGATCTCCGCCG
CAGAAATGACCAGCAGCATGCATTAGTCATGTTAAATGTTTTTGGAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTAT
TCACTTGCCGACCTGCAGCAGACCCAGGCACTACAGCCAAATCTAACCTGATCCACAGATGATTGAAGGATCGGGGGAGCTCGGCACGGG
ATGTGGCAGCAAATGTGCGGCACTAAGGACAAAGTCACTGCCTTTTGTGGAAGCCAGATCAGAAAGATGACTGTGTGTTGTGAGTGGTGG
ATAGAGAGCCCTGTTGCCCAGGTGAGAAGGAGCTCAGTTGAGATAAGGATTCCAGGAGCCAACTCGAGCCCCTCAGGTAGAGACAACAAT
ACCGGTTGAGGCTGCAGCTGTGGAGTTGGATGGTGTTTAGTCAGTGCTGAAATCACTTTCCTGGGAGTCCCTTGGCATGCAGTCATCTGA
GTGCTGTTGTTGTTGTTGGGTTTTTGTTGTTTCCTATTTTAAAAGAGTAATCATAATACTGACGAAGTGAGGGCCTGTTTTCAAAGAACA
TTTACTTAAAGATATAGAGTAAGGTTAGCATCGGTCTTGCCAGTGGTAGAAACCTATGCCACCAACAGCCATCATGAAAGGGCCCCAGGA
GTCTTTCTGGTTCTTCATTTCTATTCAGTTTGATTCAACAAGTGTGTATTGATTGAATGCTTTCTGTGTGCCAATCATTGAGCTAGCCAC
AGAGGAGGCAAAGGTGATTAAGCCACAATTCCTTCCCTCACTGAGCTCACAGTCTGATGAGAGAGGCAGATAGGCATTGTTGAAGTCAGC
GGAGTTGAACCTAGGGTACTTGGGGAATACATCTGACCAAGTGTGTGGCAGATTGTATTTTGCAAAAATAGCTGCAACAGTATCTTCCAT
CCCACATGTCTTTCTTACACTGTGACTTTGATGCTCCTCCTATTCAGTAGTGAGATCTGTGTTCCTTCTCCCCGAATTTGGGCAGGTCTG
TGACTATGGAAGTGATGCCATGTGATTTCCAAAGCCAAGTCATAAAAGGTGATATAGCTCCAACCTGGTGCTGTCTGGAGATGCTCACTC
ATGGCAACCCAGTGGCCATGTTGTAAGGAAGTCCAGATTAGCCCTCATAGAACAACCACATGAACAGGCCTCATATGGTAGTTGTTCTAG
CTGGCAGCGATCATCAGCCACCAGAGAGATGAGTGAAGACAGCCCCACATGATTCCAGCTGCTAGCCTTCAAGTCTTCTCACCTAGGCTA
GAGATGAGGCTGCAGATATTATGGAGCAGAAACAAACCATCTCCACAGTGTCCTTCCTGGAGTCCTGACCGACCGACAAAATGTGTGAGC

>In-frame_ENST00000445915_ENST00000457206_TCGA-56-8083-01A_UGP2_chr2_64085070_+_PLEKHM3_chr2_208795843_length(amino acids)=202AA_start in transcript=67_stop in transcript=675
MLLYPAGFSFASLKSDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRP
PEDSVSKQAKEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRNDQQHALVMLNVFGEFSPENT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for UGP2-PLEKHM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for UGP2-PLEKHM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for UGP2-PLEKHM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUGP2C0036572Seizures1GENOMICS_ENGLAND
HgeneUGP2C0232466Feeding difficulties1GENOMICS_ENGLAND
HgeneUGP2C0557874Global developmental delay1GENOMICS_ENGLAND
HgeneUGP2C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneUGP2C4025846Abnormality of vision1GENOMICS_ENGLAND
HgeneUGP2C4025871Abnormality of the face1GENOMICS_ENGLAND