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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BDH1-UBR3 (FusionGDB2 ID:9620)

Fusion Gene Summary for BDH1-UBR3

check button Fusion gene summary
Fusion gene informationFusion gene name: BDH1-UBR3
Fusion gene ID: 9620
HgeneTgene
Gene symbol

BDH1

UBR3

Gene ID

622

130507

Gene name3-hydroxybutyrate dehydrogenase 1ubiquitin protein ligase E3 component n-recognin 3
SynonymsBDH|SDR9C1ZNF650
Cytomap

3q29

2q31.1

Type of geneprotein-codingprotein-coding
DescriptionD-beta-hydroxybutyrate dehydrogenase, mitochondrial(R)-3-hydroxybutyrate dehydrogenase3-hydroxybutyrate dehydrogenase (heart, mitochondrial)3-hydroxybutyrate dehydrogenase, type 1epididymis secretory sperm binding proteinshort chain dehydrogenase/redE3 ubiquitin-protein ligase UBR3N-recognin-3RING-type E3 ubiquitin transferase UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)ubiquitin-protein ligase E3-alpha-3ubiquitin-protein ligase E3-alpha-IIIzinc finger protein 650
Modification date2020031320200313
UniProtAcc

Q02338

.
Ensembl transtripts involved in fusion geneENST00000392379, ENST00000392378, 
ENST00000358186, ENST00000441275, 
ENST00000476764, 		ENST00000272793, 
ENST00000418381, ENST00000392631, 
ENST00000465630, 
Fusion gene scores* DoF score5 X 5 X 4=1006 X 6 X 4=144
# samples 56
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BDH1 [Title/Abstract] AND UBR3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBDH1(197249510)-UBR3(170938234), # samples:1
Anticipated loss of major functional domain due to fusion event.BDH1-UBR3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
BDH1-UBR3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BDH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across UBR3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF679324BDH1chr3

197249510

-UBR3chr2

170938234

+


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Fusion Gene ORF analysis for BDH1-UBR3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000392379ENST00000272793BDH1chr3

197249510

-UBR3chr2

170938234

+
Frame-shiftENST00000392379ENST00000418381BDH1chr3

197249510

-UBR3chr2

170938234

+
Frame-shiftENST00000392379ENST00000392631BDH1chr3

197249510

-UBR3chr2

170938234

+
5CDS-intronENST00000392379ENST00000465630BDH1chr3

197249510

-UBR3chr2

170938234

+
In-frameENST00000392378ENST00000272793BDH1chr3

197249510

-UBR3chr2

170938234

+
Frame-shiftENST00000392378ENST00000418381BDH1chr3

197249510

-UBR3chr2

170938234

+
Frame-shiftENST00000392378ENST00000392631BDH1chr3

197249510

-UBR3chr2

170938234

+
5CDS-intronENST00000392378ENST00000465630BDH1chr3

197249510

-UBR3chr2

170938234

+
In-frameENST00000358186ENST00000272793BDH1chr3

197249510

-UBR3chr2

170938234

+
Frame-shiftENST00000358186ENST00000418381BDH1chr3

197249510

-UBR3chr2

170938234

+
Frame-shiftENST00000358186ENST00000392631BDH1chr3

197249510

-UBR3chr2

170938234

+
5CDS-intronENST00000358186ENST00000465630BDH1chr3

197249510

-UBR3chr2

170938234

+
In-frameENST00000441275ENST00000272793BDH1chr3

197249510

-UBR3chr2

170938234

+
Frame-shiftENST00000441275ENST00000418381BDH1chr3

197249510

-UBR3chr2

170938234

+
Frame-shiftENST00000441275ENST00000392631BDH1chr3

197249510

-UBR3chr2

170938234

+
5CDS-intronENST00000441275ENST00000465630BDH1chr3

197249510

-UBR3chr2

170938234

+
intron-3CDSENST00000476764ENST00000272793BDH1chr3

197249510

-UBR3chr2

170938234

+
intron-3CDSENST00000476764ENST00000418381BDH1chr3

197249510

-UBR3chr2

170938234

+
intron-3CDSENST00000476764ENST00000392631BDH1chr3

197249510

-UBR3chr2

170938234

+
intron-intronENST00000476764ENST00000465630BDH1chr3

197249510

-UBR3chr2

170938234

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392378BDH1chr3197249510-ENST00000272793UBR3chr2170938234+3126720311991226
ENST00000358186BDH1chr3197249510-ENST00000272793UBR3chr2170938234+3001595186866226
ENST00000441275BDH1chr3197249510-ENST00000272793UBR3chr2170938234+3087681356952198

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392378ENST00000272793BDH1chr3197249510-UBR3chr2170938234+0.0005949060.99940515
ENST00000358186ENST00000272793BDH1chr3197249510-UBR3chr2170938234+0.0006328430.9993672
ENST00000441275ENST00000272793BDH1chr3197249510-UBR3chr2170938234+0.0062605270.9937395

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Fusion Genomic Features for BDH1-UBR3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BDH1chr3197249510-UBR3chr2170938235+0.0016636020.9983364
BDH1chr3197249510-UBR3chr2170938235+0.0016636020.9983364

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BDH1-UBR3


check button Go to

FGviewer for the breakpoints of chr3:197249510-chr2:170938234

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BDH1

Q02338

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBDH1chr3:197249510chr2:170938234ENST00000358186-5759_83136.33333333333334344.0Nucleotide bindingNAD
HgeneBDH1chr3:197249510chr2:170938234ENST00000392378-5759_83136.33333333333334344.0Nucleotide bindingNAD
HgeneBDH1chr3:197249510chr2:170938234ENST00000392379-6859_83136.33333333333334344.0Nucleotide bindingNAD
TgeneUBR3chr3:197249510chr2:170938234ENST0000039263114161168_1199670.6666666666666710.0Coiled coilOntology_term=ECO:0000255
TgeneUBR3chr3:197249510chr2:170938234ENST0000039263114161766_1808670.6666666666666710.0Compositional biasNote=Cys-rich
TgeneUBR3chr3:197249510chr2:170938234ENST0000039263114161806_1826670.6666666666666710.0TransmembraneHelical
TgeneUBR3chr3:197249510chr2:170938234ENST000003926311416761_781670.6666666666666710.0TransmembraneHelical
TgeneUBR3chr3:197249510chr2:170938234ENST000003926311416919_939670.6666666666666710.0TransmembraneHelical
TgeneUBR3chr3:197249510chr2:170938234ENST0000039263114161306_1364670.6666666666666710.0Zinc fingerNote=RING-type%3B degenerate

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUBR3chr3:197249510chr2:170938234ENST0000027279337391168_11991849.66666666666671889.0Coiled coilOntology_term=ECO:0000255
TgeneUBR3chr3:197249510chr2:170938234ENST0000041838137391168_11991849.66666666666671889.0Coiled coilOntology_term=ECO:0000255
TgeneUBR3chr3:197249510chr2:170938234ENST0000027279337391766_18081849.66666666666671889.0Compositional biasNote=Cys-rich
TgeneUBR3chr3:197249510chr2:170938234ENST0000027279337392_1181849.66666666666671889.0Compositional biasNote=Ala-rich
TgeneUBR3chr3:197249510chr2:170938234ENST0000039263114162_118670.6666666666666710.0Compositional biasNote=Ala-rich
TgeneUBR3chr3:197249510chr2:170938234ENST0000041838137391766_18081849.66666666666671889.0Compositional biasNote=Cys-rich
TgeneUBR3chr3:197249510chr2:170938234ENST0000041838137392_1181849.66666666666671889.0Compositional biasNote=Ala-rich
TgeneUBR3chr3:197249510chr2:170938234ENST0000027279337391806_18261849.66666666666671889.0TransmembraneHelical
TgeneUBR3chr3:197249510chr2:170938234ENST000002727933739761_7811849.66666666666671889.0TransmembraneHelical
TgeneUBR3chr3:197249510chr2:170938234ENST000002727933739919_9391849.66666666666671889.0TransmembraneHelical
TgeneUBR3chr3:197249510chr2:170938234ENST0000041838137391806_18261849.66666666666671889.0TransmembraneHelical
TgeneUBR3chr3:197249510chr2:170938234ENST000004183813739761_7811849.66666666666671889.0TransmembraneHelical
TgeneUBR3chr3:197249510chr2:170938234ENST000004183813739919_9391849.66666666666671889.0TransmembraneHelical
TgeneUBR3chr3:197249510chr2:170938234ENST000002727933739118_1891849.66666666666671889.0Zinc fingerUBR-type
TgeneUBR3chr3:197249510chr2:170938234ENST0000027279337391306_13641849.66666666666671889.0Zinc fingerNote=RING-type%3B degenerate
TgeneUBR3chr3:197249510chr2:170938234ENST000003926311416118_189670.6666666666666710.0Zinc fingerUBR-type
TgeneUBR3chr3:197249510chr2:170938234ENST000004183813739118_1891849.66666666666671889.0Zinc fingerUBR-type
TgeneUBR3chr3:197249510chr2:170938234ENST0000041838137391306_13641849.66666666666671889.0Zinc fingerNote=RING-type%3B degenerate


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Fusion Gene Sequence for BDH1-UBR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000392378_ENST00000272793_BF679324_BDH1_chr3_197249510_-_UBR3_chr2_170938234_length(transcript)=3126nt_BP=720nt
GGAGGAGGCGGCTCGGCGGCCCCCCGACAGCCACGCCGCCGTGAGCCCCGCCCAGCGTAGCCCCAGCGCGCGCTTCGCGTGTAGAAGCGT
CCGGGTGGCGGAGGCCGCAGGCCGCAGGAGTGCTGGTGGAGGGGCTTCCAGAAAGACCCTGCGGCAGCGCCCCCCCTCGGCTCTCCCCGC
AGGAGAGCGGGCACCTGCGCGGCGCCGGGTGAAGGCGAGAGCCTCGGCGAGCCCTCTGCAGCGGAGCCCCCTGCCCATTTGGTTTTGGAA
CCACCGGGAGGAACTGGGCCATTCTAACACCCGTTGCTACCATGCTGGCCACCCGCCTCTCCAGACCCCTGTCACGGCTCCCAGGAAAAA
CCCTAAGTGCCTGTGATAGAGAAAATGGAGCAAGACGCCCACTATTGCTTGGTTCTACTTCCTTTATCCCGATTGGCCGTCGGACTTATG
CCAGTGCGGCGGAGCCGGTTGGCAGCAAAGCTGTCCTGGTCACAGGCTGTGACTCTGGATTTGGGTTCTCATTGGCCAAGCATCTGCATT
CAAAAGGCTTCCTTGTGTTTGCTGGCTGCTTGATGAAGGACAAAGGCCATGATGGGGTCAAGGAGCTGGACAGCCTAAACAGTGACCGAT
TGAGAACCGTCCAGCTCAATGTCTGCAGCAGCGAAGAGGTGGAGAAAGTGGTGGAGATTGTCCGCTCGAGCCTGAAGGACCCTGAGAAAG
GCGAGGCAAACCTCTCTACATTTGTAAGGAAAGATACAAAGTTCTTGAGCAACAGTGGATTTCTCATACTTTTGATCACATCAATAAAAG
ATGGGGTCCACATTACAATGGGCTGTGACTCTCCACCTCAGCATTGCATCGTATCATCATTTTCGCTACGAATTTATTTTTCAACAATAA
GCTTTAACTTAATTTGGGGGATTAACACTTTTGCTGAGGGAGAAAAAGAAAACATACATTATGAAGCCTTTCCAAAATTAGGTGCTTGGT
AATCACGTTAATGGTATAATTTTTTTTTTTTAATATCTGGAGAACATTAATAACAAGTTAAATTATTCTTTAGTGGTCATTTTTTAAGTG
CACAATTAATAAGAAGCACAACTTGTTCACAAACTCATTCAGAAATGATTCTCCCAACAATGCGTATCAGCTATTCATTGATACTTAGAG
TGGGTGTGATTTATTTGACATTTTACTGCTTCTTTCTGTCTGTGTGTTTTAATTTGCATCTGCCAAGCATAATGCATCTTTTTTCCTCTG
CCATTCTTGTGTTGATTGGAGAATTTTTCTGTATGTAATTAGAAAAAAATGTAAAACATGATTTATGTGAAATACTGTATAGTAAAAGTT
GGTCTAATAGTAGAACTTTAAAATTTTTTCTTATTGTGAGGAATCTGTTAAAAGTTTAAAGCTTTGCTGAAAACTGAATTCATTCTCAGG
AATTTCATAAATCTTCTCCCCAGGTAAATAATTGAAATAGCTGTAAAATAAGTAGATAGCTGCTGTTAATATAATACAGTACATTTTGGG
GGGCATATGTGTGGTTGGGGGGTCCTTAAAAATCAAAATTTGCCATTTCAGTTGGATGAATTACTAGAGGTAATAACAAATCTTACTATG
AAATCAAGAGGTTTAAGAACATACACTGGGCAGATGTTGATTCCGTGCATGCCCACCTTTTATTACCAAACAAGGTTTTGTTTATATGAT
TGTATTAGAAATGCTCAGACTTCCCCAGAAATGAACCATAAATTTTGGAACTTCCTTTCAGCTCAAGAGGTTCAGCTATATTGTATTTGT
GCAGTGTAATCACTACTATTTCTGCTCGGTTTCCTAAAAGGAAAAAAAAGGCGCAGTGGTGATGACCCTCATGAATGAGCCACGCTTCTG
CATTCTTCTTAGAAACTGCTGTGAAAAACAATTTATGTTTGCAGGGTTTAAAAATCAGTAAAAATGGGAATGATTGAGCTAAAACCCACT
CTATGAGAAGGAAGATTACTGAAAAGCATGTGACATATTGCTACAAAGATTTTTTTTCCTAAATGATTCAGTAATTGAATGATTATTTAA
TATATAGTGCTATCAAGCAATCCCTGGTACTTTGGACTTCCATGGCTTGTTATATAAAATTACATTTTTACATGTAAAAATAAACTAAAC
AAATCTAATGATAAAATATGTCAGATCCATGTTCTAAAAAATTTTTGTAATGACATGACATTACAAGAGTATAAAAATGGACATTAAATC
ATGGCCTTGCATTAAAATATGGAAAGCAGAGCAGTACATATTCAAATGTATTCAGAAAGTCAAAAGATTACCTATCGTTCTACAATAAAA
TACATGGAAATAGCTTGCTATTTTTATATACATTTCCAAAATATTAAGATAACTTTCTGTAAGAGTCAATGATTCTGTTCGACTAAATAG
CTGTCCTTTCCAACACATTGCTACTTTTTTAAATACTGTATCATAAGTTCAGCCTGTCATACTTTTTGCATTGATCGTTATGAATACCAG
ACCATTTGTAAGTGTGGTTGAAGAGCAAAATGCTAATTGACATCTCTAGTAAATACTGTTACAGGATTCATGAACTTGAATAATTCTACA
GTTTGAAACTCTGATGCTATATATACATGGTATAATGTATTCAGACTTTGATTACTACTTATTTAAAATGGAATGTTTTATGGTTGTGCA
TATGGATGTGAAGTGAAAATATTAGCCTTAACTTTAAAATTTGGGTGTTTGATAGTGTTTATTTTGATATTGGTGAATTAGTCACCAGTA
AATTTTAAAAAAGCACTTGGTTGAAAATTGTACTTGAATACATACATGCATGCTGCTAAACTAGAACTTTAATTTTTCCCCATAACTTTT
ATAAGTCCCATTTATAAACCCACTTTTAAAAATAACAGGTCCAAGTTAGAGTGATGTGTGTATATTATTCAAAAAAATGTACTGGTGTGA
TATCTTGTATGAATGATCATTTAAATACAGTACATTACTGTAGAAGCTAAATTGATCTTTATAATTAAGCAGAAATTACAAAACTAGGAA

>In-frame_ENST00000392378_ENST00000272793_BF679324_BDH1_chr3_197249510_-_UBR3_chr2_170938234_length(amino acids)=226AA_start in transcript=311_stop in transcript=991
MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKD
KGHDGVKELDSLNSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGEANLSTFVRKDTKFLSNSGFLILLITSIKDGVHITMGCDSPPQ

--------------------------------------------------------------
>In-frame_ENST00000358186_ENST00000272793_BF679324_BDH1_chr3_197249510_-_UBR3_chr2_170938234_length(transcript)=3001nt_BP=595nt
ATTGAAAGAATACACAGAAAGCCTGGAAAAGGTTTCCAGGGGTGTCAATACGCCCTGTCAACTGAGAATTAAGAGGATCCGGCTGGTCAC
TTGCCTGGAGAGGATCCTGCATGCTGATAGTGCTGAGGCACCTGCCAGCTAAGAACCACCGGGAGGAACTGGGCCATTCTAACACCCGTT
GCTACCATGCTGGCCACCCGCCTCTCCAGACCCCTGTCACGGCTCCCAGGAAAAACCCTAAGTGCCTGTGATAGAGAAAATGGAGCAAGA
CGCCCACTATTGCTTGGTTCTACTTCCTTTATCCCGATTGGCCGTCGGACTTATGCCAGTGCGGCGGAGCCGGTTGGCAGCAAAGCTGTC
CTGGTCACAGGCTGTGACTCTGGATTTGGGTTCTCATTGGCCAAGCATCTGCATTCAAAAGGCTTCCTTGTGTTTGCTGGCTGCTTGATG
AAGGACAAAGGCCATGATGGGGTCAAGGAGCTGGACAGCCTAAACAGTGACCGATTGAGAACCGTCCAGCTCAATGTCTGCAGCAGCGAA
GAGGTGGAGAAAGTGGTGGAGATTGTCCGCTCGAGCCTGAAGGACCCTGAGAAAGGCGAGGCAAACCTCTCTACATTTGTAAGGAAAGAT
ACAAAGTTCTTGAGCAACAGTGGATTTCTCATACTTTTGATCACATCAATAAAAGATGGGGTCCACATTACAATGGGCTGTGACTCTCCA
CCTCAGCATTGCATCGTATCATCATTTTCGCTACGAATTTATTTTTCAACAATAAGCTTTAACTTAATTTGGGGGATTAACACTTTTGCT
GAGGGAGAAAAAGAAAACATACATTATGAAGCCTTTCCAAAATTAGGTGCTTGGTAATCACGTTAATGGTATAATTTTTTTTTTTTAATA
TCTGGAGAACATTAATAACAAGTTAAATTATTCTTTAGTGGTCATTTTTTAAGTGCACAATTAATAAGAAGCACAACTTGTTCACAAACT
CATTCAGAAATGATTCTCCCAACAATGCGTATCAGCTATTCATTGATACTTAGAGTGGGTGTGATTTATTTGACATTTTACTGCTTCTTT
CTGTCTGTGTGTTTTAATTTGCATCTGCCAAGCATAATGCATCTTTTTTCCTCTGCCATTCTTGTGTTGATTGGAGAATTTTTCTGTATG
TAATTAGAAAAAAATGTAAAACATGATTTATGTGAAATACTGTATAGTAAAAGTTGGTCTAATAGTAGAACTTTAAAATTTTTTCTTATT
GTGAGGAATCTGTTAAAAGTTTAAAGCTTTGCTGAAAACTGAATTCATTCTCAGGAATTTCATAAATCTTCTCCCCAGGTAAATAATTGA
AATAGCTGTAAAATAAGTAGATAGCTGCTGTTAATATAATACAGTACATTTTGGGGGGCATATGTGTGGTTGGGGGGTCCTTAAAAATCA
AAATTTGCCATTTCAGTTGGATGAATTACTAGAGGTAATAACAAATCTTACTATGAAATCAAGAGGTTTAAGAACATACACTGGGCAGAT
GTTGATTCCGTGCATGCCCACCTTTTATTACCAAACAAGGTTTTGTTTATATGATTGTATTAGAAATGCTCAGACTTCCCCAGAAATGAA
CCATAAATTTTGGAACTTCCTTTCAGCTCAAGAGGTTCAGCTATATTGTATTTGTGCAGTGTAATCACTACTATTTCTGCTCGGTTTCCT
AAAAGGAAAAAAAAGGCGCAGTGGTGATGACCCTCATGAATGAGCCACGCTTCTGCATTCTTCTTAGAAACTGCTGTGAAAAACAATTTA
TGTTTGCAGGGTTTAAAAATCAGTAAAAATGGGAATGATTGAGCTAAAACCCACTCTATGAGAAGGAAGATTACTGAAAAGCATGTGACA
TATTGCTACAAAGATTTTTTTTCCTAAATGATTCAGTAATTGAATGATTATTTAATATATAGTGCTATCAAGCAATCCCTGGTACTTTGG
ACTTCCATGGCTTGTTATATAAAATTACATTTTTACATGTAAAAATAAACTAAACAAATCTAATGATAAAATATGTCAGATCCATGTTCT
AAAAAATTTTTGTAATGACATGACATTACAAGAGTATAAAAATGGACATTAAATCATGGCCTTGCATTAAAATATGGAAAGCAGAGCAGT
ACATATTCAAATGTATTCAGAAAGTCAAAAGATTACCTATCGTTCTACAATAAAATACATGGAAATAGCTTGCTATTTTTATATACATTT
CCAAAATATTAAGATAACTTTCTGTAAGAGTCAATGATTCTGTTCGACTAAATAGCTGTCCTTTCCAACACATTGCTACTTTTTTAAATA
CTGTATCATAAGTTCAGCCTGTCATACTTTTTGCATTGATCGTTATGAATACCAGACCATTTGTAAGTGTGGTTGAAGAGCAAAATGCTA
ATTGACATCTCTAGTAAATACTGTTACAGGATTCATGAACTTGAATAATTCTACAGTTTGAAACTCTGATGCTATATATACATGGTATAA
TGTATTCAGACTTTGATTACTACTTATTTAAAATGGAATGTTTTATGGTTGTGCATATGGATGTGAAGTGAAAATATTAGCCTTAACTTT
AAAATTTGGGTGTTTGATAGTGTTTATTTTGATATTGGTGAATTAGTCACCAGTAAATTTTAAAAAAGCACTTGGTTGAAAATTGTACTT
GAATACATACATGCATGCTGCTAAACTAGAACTTTAATTTTTCCCCATAACTTTTATAAGTCCCATTTATAAACCCACTTTTAAAAATAA
CAGGTCCAAGTTAGAGTGATGTGTGTATATTATTCAAAAAAATGTACTGGTGTGATATCTTGTATGAATGATCATTTAAATACAGTACAT
TACTGTAGAAGCTAAATTGATCTTTATAATTAAGCAGAAATTACAAAACTAGGAATAATCAACATTGTAAGATATGTTAATAAAAACCTG

>In-frame_ENST00000358186_ENST00000272793_BF679324_BDH1_chr3_197249510_-_UBR3_chr2_170938234_length(amino acids)=226AA_start in transcript=186_stop in transcript=866
MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKD
KGHDGVKELDSLNSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGEANLSTFVRKDTKFLSNSGFLILLITSIKDGVHITMGCDSPPQ

--------------------------------------------------------------
>In-frame_ENST00000441275_ENST00000272793_BF679324_BDH1_chr3_197249510_-_UBR3_chr2_170938234_length(transcript)=3087nt_BP=681nt
CCCAGCGCGCGCTTCGCGTGTAGAAGCGTCCGGGTGGCGGAGGCCGCAGGCCGCAGGAGTGCTGGTGGAGGGGCTTCCAGAAAGACCCTG
CGGCAGCGCCCCCCCTCGGCTCTCCCCGCAGGAGAGCGGGCACCTGCGCGGCGCCGGGTGAAGGCGAGAGCCTCGGCGAGCCCTCTGCAG
CGGAGCCCCCTGCCCATTTGGTTTTGGCCAGTCAGCCTGGAAATCTGCCTGTAGTCAGCTGATGCAGAGTCACCCTGCAGTTCCTACTTT
GAGGGGTTGCAGAAGCACATATTTCACTATGGAGGGCCGCCTGCAGGCCTCGCGCTGACAGGATCTTTTGTGACGCTGCAAATGTCCTGA
CGCCCACTATTGCTTGGTTCTACTTCCTTTATCCCGATTGGCCGTCGGACTTATGCCAGTGCGGCGGAGCCGGTGACAAAGCTGTCCTGG
TCACAGGCTGTGACTCTGGATTTGGGTTCTCATTGGCCAAGCATCTGCATTCAAAAGGCTTCCTTGTGTTTGCTGGCTGCTTGATGAAGG
ACAAAGGCCATGATGGGGTCAAGGAGCTGGACAGCCTAAACAGTGACCGATTGAGAACCGTCCAGCTCAATGTCTGCAGCAGCGAAGAGG
TGGAGAAAGTGGTGGAGATTGTCCGCTCGAGCCTGAAGGACCCTGAGAAAGGCGAGGCAAACCTCTCTACATTTGTAAGGAAAGATACAA
AGTTCTTGAGCAACAGTGGATTTCTCATACTTTTGATCACATCAATAAAAGATGGGGTCCACATTACAATGGGCTGTGACTCTCCACCTC
AGCATTGCATCGTATCATCATTTTCGCTACGAATTTATTTTTCAACAATAAGCTTTAACTTAATTTGGGGGATTAACACTTTTGCTGAGG
GAGAAAAAGAAAACATACATTATGAAGCCTTTCCAAAATTAGGTGCTTGGTAATCACGTTAATGGTATAATTTTTTTTTTTTAATATCTG
GAGAACATTAATAACAAGTTAAATTATTCTTTAGTGGTCATTTTTTAAGTGCACAATTAATAAGAAGCACAACTTGTTCACAAACTCATT
CAGAAATGATTCTCCCAACAATGCGTATCAGCTATTCATTGATACTTAGAGTGGGTGTGATTTATTTGACATTTTACTGCTTCTTTCTGT
CTGTGTGTTTTAATTTGCATCTGCCAAGCATAATGCATCTTTTTTCCTCTGCCATTCTTGTGTTGATTGGAGAATTTTTCTGTATGTAAT
TAGAAAAAAATGTAAAACATGATTTATGTGAAATACTGTATAGTAAAAGTTGGTCTAATAGTAGAACTTTAAAATTTTTTCTTATTGTGA
GGAATCTGTTAAAAGTTTAAAGCTTTGCTGAAAACTGAATTCATTCTCAGGAATTTCATAAATCTTCTCCCCAGGTAAATAATTGAAATA
GCTGTAAAATAAGTAGATAGCTGCTGTTAATATAATACAGTACATTTTGGGGGGCATATGTGTGGTTGGGGGGTCCTTAAAAATCAAAAT
TTGCCATTTCAGTTGGATGAATTACTAGAGGTAATAACAAATCTTACTATGAAATCAAGAGGTTTAAGAACATACACTGGGCAGATGTTG
ATTCCGTGCATGCCCACCTTTTATTACCAAACAAGGTTTTGTTTATATGATTGTATTAGAAATGCTCAGACTTCCCCAGAAATGAACCAT
AAATTTTGGAACTTCCTTTCAGCTCAAGAGGTTCAGCTATATTGTATTTGTGCAGTGTAATCACTACTATTTCTGCTCGGTTTCCTAAAA
GGAAAAAAAAGGCGCAGTGGTGATGACCCTCATGAATGAGCCACGCTTCTGCATTCTTCTTAGAAACTGCTGTGAAAAACAATTTATGTT
TGCAGGGTTTAAAAATCAGTAAAAATGGGAATGATTGAGCTAAAACCCACTCTATGAGAAGGAAGATTACTGAAAAGCATGTGACATATT
GCTACAAAGATTTTTTTTCCTAAATGATTCAGTAATTGAATGATTATTTAATATATAGTGCTATCAAGCAATCCCTGGTACTTTGGACTT
CCATGGCTTGTTATATAAAATTACATTTTTACATGTAAAAATAAACTAAACAAATCTAATGATAAAATATGTCAGATCCATGTTCTAAAA
AATTTTTGTAATGACATGACATTACAAGAGTATAAAAATGGACATTAAATCATGGCCTTGCATTAAAATATGGAAAGCAGAGCAGTACAT
ATTCAAATGTATTCAGAAAGTCAAAAGATTACCTATCGTTCTACAATAAAATACATGGAAATAGCTTGCTATTTTTATATACATTTCCAA
AATATTAAGATAACTTTCTGTAAGAGTCAATGATTCTGTTCGACTAAATAGCTGTCCTTTCCAACACATTGCTACTTTTTTAAATACTGT
ATCATAAGTTCAGCCTGTCATACTTTTTGCATTGATCGTTATGAATACCAGACCATTTGTAAGTGTGGTTGAAGAGCAAAATGCTAATTG
ACATCTCTAGTAAATACTGTTACAGGATTCATGAACTTGAATAATTCTACAGTTTGAAACTCTGATGCTATATATACATGGTATAATGTA
TTCAGACTTTGATTACTACTTATTTAAAATGGAATGTTTTATGGTTGTGCATATGGATGTGAAGTGAAAATATTAGCCTTAACTTTAAAA
TTTGGGTGTTTGATAGTGTTTATTTTGATATTGGTGAATTAGTCACCAGTAAATTTTAAAAAAGCACTTGGTTGAAAATTGTACTTGAAT
ACATACATGCATGCTGCTAAACTAGAACTTTAATTTTTCCCCATAACTTTTATAAGTCCCATTTATAAACCCACTTTTAAAAATAACAGG
TCCAAGTTAGAGTGATGTGTGTATATTATTCAAAAAAATGTACTGGTGTGATATCTTGTATGAATGATCATTTAAATACAGTACATTACT
GTAGAAGCTAAATTGATCTTTATAATTAAGCAGAAATTACAAAACTAGGAATAATCAACATTGTAAGATATGTTAATAAAAACCTGCTGT

>In-frame_ENST00000441275_ENST00000272793_BF679324_BDH1_chr3_197249510_-_UBR3_chr2_170938234_length(amino acids)=198AA_start in transcript=356_stop in transcript=952
MTPTIAWFYFLYPDWPSDLCQCGGAGDKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSE
EVEKVVEIVRSSLKDPEKGEANLSTFVRKDTKFLSNSGFLILLITSIKDGVHITMGCDSPPQHCIVSSFSLRIYFSTISFNLIWGINTFA

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Fusion Gene PPI Analysis for BDH1-UBR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BDH1-UBR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneBDH1Q02338DB00157NADHSmall moleculeApproved|Nutraceutical
HgeneBDH1Q02338DB00157NADHSmall moleculeApproved|Nutraceutical
HgeneBDH1Q02338DB00157NADHSmall moleculeApproved|Nutraceutical

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Related Diseases for BDH1-UBR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBDH1C0023893Liver Cirrhosis, Experimental2CTD_human
HgeneBDH1C0019193Hepatitis, Toxic1CTD_human
HgeneBDH1C0860207Drug-Induced Liver Disease1CTD_human
HgeneBDH1C1262760Hepatitis, Drug-Induced1CTD_human
HgeneBDH1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneBDH1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneBDH1C4279912Chemically-Induced Liver Toxicity1CTD_human