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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:URI1-PEPD (FusionGDB2 ID:96418)

Fusion Gene Summary for URI1-PEPD

check button Fusion gene summary
Fusion gene informationFusion gene name: URI1-PEPD
Fusion gene ID: 96418
HgeneTgene
Gene symbol

URI1

PEPD

Gene ID

8725

5184

Gene nameURI1 prefoldin like chaperonepeptidase D
SynonymsC19orf2|NNX3|PPP1R19|RMP|URIPROLIDASE
Cytomap

19q12

19q13.11

Type of geneprotein-codingprotein-coding
Descriptionunconventional prefoldin RPB5 interactor 1RNA polymerase II subunit 5-mediating proteinRPB5-mediating proteinprotein phosphatase 1, regulatory subunit 19xaa-Pro dipeptidaseX-Pro dipeptidaseaminoacyl-L-proline hydrolaseimidodipeptidaseproline dipeptidasetesticular tissue protein Li 138
Modification date2020031320200313
UniProtAcc

O94763

.
Ensembl transtripts involved in fusion geneENST00000360605, ENST00000542441, 
ENST00000392271, ENST00000312051, 
ENST00000574176, 		ENST00000244137, 
ENST00000397032, ENST00000436370, 
ENST00000591968, 
Fusion gene scores* DoF score30 X 13 X 12=468018 X 11 X 13=2574
# samples 4023
** MAII scorelog2(40/4680*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2574*10)=-3.48430628727633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: URI1 [Title/Abstract] AND PEPD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointURI1(30462134)-PEPD(33904549), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneURI1

GO:0000122

negative regulation of transcription by RNA polymerase II

12737519|15367675|21730289

HgeneURI1

GO:0001558

regulation of cell growth

21730289

HgeneURI1

GO:0071363

cellular response to growth factor stimulus

17936702

HgeneURI1

GO:0071383

cellular response to steroid hormone stimulus

21730289


check buttonFusion gene breakpoints across URI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PEPD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-ZG-A9LZ-01AURI1chr19

30462134

+PEPDchr19

33904549

-
ChimerDB4PRADTCGA-ZG-A9LZURI1chr19

30462134

+PEPDchr19

33904549

-


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Fusion Gene ORF analysis for URI1-PEPD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000360605ENST00000244137URI1chr19

30462134

+PEPDchr19

33904549

-
In-frameENST00000360605ENST00000397032URI1chr19

30462134

+PEPDchr19

33904549

-
In-frameENST00000360605ENST00000436370URI1chr19

30462134

+PEPDchr19

33904549

-
5CDS-intronENST00000360605ENST00000591968URI1chr19

30462134

+PEPDchr19

33904549

-
In-frameENST00000542441ENST00000244137URI1chr19

30462134

+PEPDchr19

33904549

-
In-frameENST00000542441ENST00000397032URI1chr19

30462134

+PEPDchr19

33904549

-
In-frameENST00000542441ENST00000436370URI1chr19

30462134

+PEPDchr19

33904549

-
5CDS-intronENST00000542441ENST00000591968URI1chr19

30462134

+PEPDchr19

33904549

-
5UTR-3CDSENST00000392271ENST00000244137URI1chr19

30462134

+PEPDchr19

33904549

-
5UTR-3CDSENST00000392271ENST00000397032URI1chr19

30462134

+PEPDchr19

33904549

-
5UTR-3CDSENST00000392271ENST00000436370URI1chr19

30462134

+PEPDchr19

33904549

-
5UTR-intronENST00000392271ENST00000591968URI1chr19

30462134

+PEPDchr19

33904549

-
intron-3CDSENST00000312051ENST00000244137URI1chr19

30462134

+PEPDchr19

33904549

-
intron-3CDSENST00000312051ENST00000397032URI1chr19

30462134

+PEPDchr19

33904549

-
intron-3CDSENST00000312051ENST00000436370URI1chr19

30462134

+PEPDchr19

33904549

-
intron-intronENST00000312051ENST00000591968URI1chr19

30462134

+PEPDchr19

33904549

-
intron-3CDSENST00000574176ENST00000244137URI1chr19

30462134

+PEPDchr19

33904549

-
intron-3CDSENST00000574176ENST00000397032URI1chr19

30462134

+PEPDchr19

33904549

-
intron-3CDSENST00000574176ENST00000436370URI1chr19

30462134

+PEPDchr19

33904549

-
intron-intronENST00000574176ENST00000591968URI1chr19

30462134

+PEPDchr19

33904549

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360605URI1chr1930462134+ENST00000244137PEPDchr1933904549-135114630956308
ENST00000360605URI1chr1930462134+ENST00000397032PEPDchr1933904549-132114630956308
ENST00000360605URI1chr1930462134+ENST00000436370PEPDchr1933904549-127714630956308
ENST00000542441URI1chr1930462134+ENST00000244137PEPDchr1933904549-16544492971259320
ENST00000542441URI1chr1930462134+ENST00000397032PEPDchr1933904549-16244492971259320
ENST00000542441URI1chr1930462134+ENST00000436370PEPDchr1933904549-15804492971259320

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360605ENST00000244137URI1chr1930462134+PEPDchr1933904549-0.0112175760.98878247
ENST00000360605ENST00000397032URI1chr1930462134+PEPDchr1933904549-0.0122533660.9877466
ENST00000360605ENST00000436370URI1chr1930462134+PEPDchr1933904549-0.0134111080.9865889
ENST00000542441ENST00000244137URI1chr1930462134+PEPDchr1933904549-0.0107431870.9892568
ENST00000542441ENST00000397032URI1chr1930462134+PEPDchr1933904549-0.0113915980.98860836
ENST00000542441ENST00000436370URI1chr1930462134+PEPDchr1933904549-0.0112544580.9887455

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Fusion Genomic Features for URI1-PEPD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for URI1-PEPD


check button Go to

FGviewer for the breakpoints of chr19:30462134-chr19:33904549

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
URI1

O94763

.
FUNCTION: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneURI1chr19:30462134chr19:33904549ENST00000360605+211299_31132.666666666666664476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30462134chr19:33904549ENST00000360605+211314_32132.666666666666664476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30462134chr19:33904549ENST00000392271+211299_3110460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30462134chr19:33904549ENST00000392271+211314_3210460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30462134chr19:33904549ENST00000542441+211299_31150.666666666666664536.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30462134chr19:33904549ENST00000542441+211314_32150.666666666666664536.0Compositional biasNote=Poly-Asp


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Fusion Gene Sequence for URI1-PEPD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000360605_ENST00000244137_TCGA-ZG-A9LZ-01A_URI1_chr19_30462134_+_PEPD_chr19_33904549_length(transcript)=1351nt_BP=146nt
AGTGGGTCTTCTCACTCTTTTCCAGGCTCCTTGGAGGTCACTGCCCTGATGACAACATGGTCTTCCCTTCAAGGAAGCCACGTTTCTAAG
AGGGCTCTGGCATATGCATTGGTGGTCACTAACTGCCAAGAGAGAATCCAGCATTGCCTCTTCGAGCACTACTGCTACTCCCGGGGCGGC
ATGCGCCACAGCTCCTACACCTGCATCTGCGGCAGTGGTGAGAACTCAGCCGTGCTACACTACGGACACGCCGGAGCTCCCAACGACCGA
ACGATCCAGAATGGGGATATGTGCCTGTTCGACATGGGCGGTGAGTATTACTGCTTCGCTTCCGACATCACCTGCTCCTTTCCCGCCAAC
GGCAAGTTCACTGCAGACCAGAAGGCCGTCTATGAGGCAGTGCTGCGGAGCTCCCGTGCCGTCATGGGTGCCATGAAGCCAGGTGTCTGG
TGGCCTGACATGCACCGCCTGGCTGACCGCATCCACCTGGAGGAGCTGGCCCACATGGGCATCCTGAGCGGCAGCGTGGACGCCATGGTC
CAGGCTCACCTGGGGGCCGTGTTTATGCCTCACGGGCTTGGCCACTTCCTGGGCATTGACGTGCACGACGTGGGAGGCTACCCAGAGGGC
GTGGAGCGCATCGACGAGCCCGGCCTGCGGAGCCTGCGCACTGCACGGCACCTGCAGCCAGGCATGGTGCTCACCGTGGAGCCGGGCATC
TACTTCATCGACCACCTCCTGGATGAGGCCCTGGCGGACCCGGCCCGCGCCTCCTTCCTTAACCGCGAGGTCCTGCAGCGCTTTCGCGGT
TTTGGCGGGGTCCGCATCGAGGAGGACGTCGTGGTGACTGACAGCGGCATAGAGCTGCTGACCTGCGTGCCCCGCACTGTGGAAGAGATT
GAAGCATGCATGGCAGGCTGTGACAAGGCCTTTACCCCCTTCTCTGGCCCCAAGTAGAGCCAGCCAGAAATCCCAGCGCACCTGGGGGCC
TGGCCTTGCAACCTCTTTTCGTGATGGGCAGCCTGCTGGTCAGCACTCCAGTAGCGAGAGACGGCACCCAGAATCAGATCCCAGCTTCGG
CATTTGATCAGACCAAACAGTGCTGTTTCCCGGGGAGGAAACACTTTTTTAATTACCCTTTTGCAGGCTCCCACCTTTAATCTGTTTTAT
ACCTTGCTTATTAAATGAGCGACTTAAAATGATTGAAAATAATGCTGTTCTTTAGTAGCAACTAAAATGTGTCTTGCTGTCATTTATATT
CCTTTTCCCAGGAAAGAAGCATTTCTGATACTTTCTGTCAAAAATCAATATGCAGAATGGCATTTGCAATAAAAGGTTTCCTAAAATGGT

>In-frame_ENST00000360605_ENST00000244137_TCGA-ZG-A9LZ-01A_URI1_chr19_30462134_+_PEPD_chr19_33904549_length(amino acids)=308AA_start in transcript=30_stop in transcript=956
MEVTALMTTWSSLQGSHVSKRALAYALVVTNCQERIQHCLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLF
DMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMP
HGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDV

--------------------------------------------------------------
>In-frame_ENST00000360605_ENST00000397032_TCGA-ZG-A9LZ-01A_URI1_chr19_30462134_+_PEPD_chr19_33904549_length(transcript)=1321nt_BP=146nt
AGTGGGTCTTCTCACTCTTTTCCAGGCTCCTTGGAGGTCACTGCCCTGATGACAACATGGTCTTCCCTTCAAGGAAGCCACGTTTCTAAG
AGGGCTCTGGCATATGCATTGGTGGTCACTAACTGCCAAGAGAGAATCCAGCATTGCCTCTTCGAGCACTACTGCTACTCCCGGGGCGGC
ATGCGCCACAGCTCCTACACCTGCATCTGCGGCAGTGGTGAGAACTCAGCCGTGCTACACTACGGACACGCCGGAGCTCCCAACGACCGA
ACGATCCAGAATGGGGATATGTGCCTGTTCGACATGGGCGGTGAGTATTACTGCTTCGCTTCCGACATCACCTGCTCCTTTCCCGCCAAC
GGCAAGTTCACTGCAGACCAGAAGGCCGTCTATGAGGCAGTGCTGCGGAGCTCCCGTGCCGTCATGGGTGCCATGAAGCCAGGTGTCTGG
TGGCCTGACATGCACCGCCTGGCTGACCGCATCCACCTGGAGGAGCTGGCCCACATGGGCATCCTGAGCGGCAGCGTGGACGCCATGGTC
CAGGCTCACCTGGGGGCCGTGTTTATGCCTCACGGGCTTGGCCACTTCCTGGGCATTGACGTGCACGACGTGGGAGGCTACCCAGAGGGC
GTGGAGCGCATCGACGAGCCCGGCCTGCGGAGCCTGCGCACTGCACGGCACCTGCAGCCAGGCATGGTGCTCACCGTGGAGCCGGGCATC
TACTTCATCGACCACCTCCTGGATGAGGCCCTGGCGGACCCGGCCCGCGCCTCCTTCCTTAACCGCGAGGTCCTGCAGCGCTTTCGCGGT
TTTGGCGGGGTCCGCATCGAGGAGGACGTCGTGGTGACTGACAGCGGCATAGAGCTGCTGACCTGCGTGCCCCGCACTGTGGAAGAGATT
GAAGCATGCATGGCAGGCTGTGACAAGGCCTTTACCCCCTTCTCTGGCCCCAAGTAGAGCCAGCCAGAAATCCCAGCGCACCTGGGGGCC
TGGCCTTGCAACCTCTTTTCGTGATGGGCAGCCTGCTGGTCAGCACTCCAGTAGCGAGAGACGGCACCCAGAATCAGATCCCAGCTTCGG
CATTTGATCAGACCAAACAGTGCTGTTTCCCGGGGAGGAAACACTTTTTTAATTACCCTTTTGCAGGCTCCCACCTTTAATCTGTTTTAT
ACCTTGCTTATTAAATGAGCGACTTAAAATGATTGAAAATAATGCTGTTCTTTAGTAGCAACTAAAATGTGTCTTGCTGTCATTTATATT

>In-frame_ENST00000360605_ENST00000397032_TCGA-ZG-A9LZ-01A_URI1_chr19_30462134_+_PEPD_chr19_33904549_length(amino acids)=308AA_start in transcript=30_stop in transcript=956
MEVTALMTTWSSLQGSHVSKRALAYALVVTNCQERIQHCLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLF
DMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMP
HGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDV

--------------------------------------------------------------
>In-frame_ENST00000360605_ENST00000436370_TCGA-ZG-A9LZ-01A_URI1_chr19_30462134_+_PEPD_chr19_33904549_length(transcript)=1277nt_BP=146nt
AGTGGGTCTTCTCACTCTTTTCCAGGCTCCTTGGAGGTCACTGCCCTGATGACAACATGGTCTTCCCTTCAAGGAAGCCACGTTTCTAAG
AGGGCTCTGGCATATGCATTGGTGGTCACTAACTGCCAAGAGAGAATCCAGCATTGCCTCTTCGAGCACTACTGCTACTCCCGGGGCGGC
ATGCGCCACAGCTCCTACACCTGCATCTGCGGCAGTGGTGAGAACTCAGCCGTGCTACACTACGGACACGCCGGAGCTCCCAACGACCGA
ACGATCCAGAATGGGGATATGTGCCTGTTCGACATGGGCGGTGAGTATTACTGCTTCGCTTCCGACATCACCTGCTCCTTTCCCGCCAAC
GGCAAGTTCACTGCAGACCAGAAGGCCGTCTATGAGGCAGTGCTGCGGAGCTCCCGTGCCGTCATGGGTGCCATGAAGCCAGGTGTCTGG
TGGCCTGACATGCACCGCCTGGCTGACCGCATCCACCTGGAGGAGCTGGCCCACATGGGCATCCTGAGCGGCAGCGTGGACGCCATGGTC
CAGGCTCACCTGGGGGCCGTGTTTATGCCTCACGGGCTTGGCCACTTCCTGGGCATTGACGTGCACGACGTGGGAGGCTACCCAGAGGGC
GTGGAGCGCATCGACGAGCCCGGCCTGCGGAGCCTGCGCACTGCACGGCACCTGCAGCCAGGCATGGTGCTCACCGTGGAGCCGGGCATC
TACTTCATCGACCACCTCCTGGATGAGGCCCTGGCGGACCCGGCCCGCGCCTCCTTCCTTAACCGCGAGGTCCTGCAGCGCTTTCGCGGT
TTTGGCGGGGTCCGCATCGAGGAGGACGTCGTGGTGACTGACAGCGGCATAGAGCTGCTGACCTGCGTGCCCCGCACTGTGGAAGAGATT
GAAGCATGCATGGCAGGCTGTGACAAGGCCTTTACCCCCTTCTCTGGCCCCAAGTAGAGCCAGCCAGAAATCCCAGCGCACCTGGGGGCC
TGGCCTTGCAACCTCTTTTCGTGATGGGCAGCCTGCTGGTCAGCACTCCAGTAGCGAGAGACGGCACCCAGAATCAGATCCCAGCTTCGG
CATTTGATCAGACCAAACAGTGCTGTTTCCCGGGGAGGAAACACTTTTTTAATTACCCTTTTGCAGGCTCCCACCTTTAATCTGTTTTAT
ACCTTGCTTATTAAATGAGCGACTTAAAATGATTGAAAATAATGCTGTTCTTTAGTAGCAACTAAAATGTGTCTTGCTGTCATTTATATT

>In-frame_ENST00000360605_ENST00000436370_TCGA-ZG-A9LZ-01A_URI1_chr19_30462134_+_PEPD_chr19_33904549_length(amino acids)=308AA_start in transcript=30_stop in transcript=956
MEVTALMTTWSSLQGSHVSKRALAYALVVTNCQERIQHCLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLF
DMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMP
HGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDV

--------------------------------------------------------------
>In-frame_ENST00000542441_ENST00000244137_TCGA-ZG-A9LZ-01A_URI1_chr19_30462134_+_PEPD_chr19_33904549_length(transcript)=1654nt_BP=449nt
GCGGCCGCCACGCGACGCCTGGCTGGGCCCGCACCGGAGAGGCGTCTCGGTACCTGGCAGGCGGCCTGCTACTCGGAGCCCGCTGCGGGG
CGGCGGCGGCGGGGACATGCACGTGTGAGATGCGGCAGCGGGCGGCGCGGACGCGAACAGCAGCGGCGGCGGCGGGCGCGGCCTCCTGGG
CGCGGGGCGCGCGGTGCCTGAGGGCGGGCGCGCGGGCGCTGGGCAACTGCCGGCCGCGCCGCCTGCGCAGGCGCTGGTTCAGGACTCACA
CGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCTGCC
CTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGTGGTCACTAACTGCCAAGAGAGAATCCAGCATTGC
CTCTTCGAGCACTACTGCTACTCCCGGGGCGGCATGCGCCACAGCTCCTACACCTGCATCTGCGGCAGTGGTGAGAACTCAGCCGTGCTA
CACTACGGACACGCCGGAGCTCCCAACGACCGAACGATCCAGAATGGGGATATGTGCCTGTTCGACATGGGCGGTGAGTATTACTGCTTC
GCTTCCGACATCACCTGCTCCTTTCCCGCCAACGGCAAGTTCACTGCAGACCAGAAGGCCGTCTATGAGGCAGTGCTGCGGAGCTCCCGT
GCCGTCATGGGTGCCATGAAGCCAGGTGTCTGGTGGCCTGACATGCACCGCCTGGCTGACCGCATCCACCTGGAGGAGCTGGCCCACATG
GGCATCCTGAGCGGCAGCGTGGACGCCATGGTCCAGGCTCACCTGGGGGCCGTGTTTATGCCTCACGGGCTTGGCCACTTCCTGGGCATT
GACGTGCACGACGTGGGAGGCTACCCAGAGGGCGTGGAGCGCATCGACGAGCCCGGCCTGCGGAGCCTGCGCACTGCACGGCACCTGCAG
CCAGGCATGGTGCTCACCGTGGAGCCGGGCATCTACTTCATCGACCACCTCCTGGATGAGGCCCTGGCGGACCCGGCCCGCGCCTCCTTC
CTTAACCGCGAGGTCCTGCAGCGCTTTCGCGGTTTTGGCGGGGTCCGCATCGAGGAGGACGTCGTGGTGACTGACAGCGGCATAGAGCTG
CTGACCTGCGTGCCCCGCACTGTGGAAGAGATTGAAGCATGCATGGCAGGCTGTGACAAGGCCTTTACCCCCTTCTCTGGCCCCAAGTAG
AGCCAGCCAGAAATCCCAGCGCACCTGGGGGCCTGGCCTTGCAACCTCTTTTCGTGATGGGCAGCCTGCTGGTCAGCACTCCAGTAGCGA
GAGACGGCACCCAGAATCAGATCCCAGCTTCGGCATTTGATCAGACCAAACAGTGCTGTTTCCCGGGGAGGAAACACTTTTTTAATTACC
CTTTTGCAGGCTCCCACCTTTAATCTGTTTTATACCTTGCTTATTAAATGAGCGACTTAAAATGATTGAAAATAATGCTGTTCTTTAGTA
GCAACTAAAATGTGTCTTGCTGTCATTTATATTCCTTTTCCCAGGAAAGAAGCATTTCTGATACTTTCTGTCAAAAATCAATATGCAGAA

>In-frame_ENST00000542441_ENST00000244137_TCGA-ZG-A9LZ-01A_URI1_chr19_30462134_+_PEPD_chr19_33904549_length(amino acids)=320AA_start in transcript=297_stop in transcript=1259
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHCLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPN
DRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDA
MVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRF

--------------------------------------------------------------
>In-frame_ENST00000542441_ENST00000397032_TCGA-ZG-A9LZ-01A_URI1_chr19_30462134_+_PEPD_chr19_33904549_length(transcript)=1624nt_BP=449nt
GCGGCCGCCACGCGACGCCTGGCTGGGCCCGCACCGGAGAGGCGTCTCGGTACCTGGCAGGCGGCCTGCTACTCGGAGCCCGCTGCGGGG
CGGCGGCGGCGGGGACATGCACGTGTGAGATGCGGCAGCGGGCGGCGCGGACGCGAACAGCAGCGGCGGCGGCGGGCGCGGCCTCCTGGG
CGCGGGGCGCGCGGTGCCTGAGGGCGGGCGCGCGGGCGCTGGGCAACTGCCGGCCGCGCCGCCTGCGCAGGCGCTGGTTCAGGACTCACA
CGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCTGCC
CTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGTGGTCACTAACTGCCAAGAGAGAATCCAGCATTGC
CTCTTCGAGCACTACTGCTACTCCCGGGGCGGCATGCGCCACAGCTCCTACACCTGCATCTGCGGCAGTGGTGAGAACTCAGCCGTGCTA
CACTACGGACACGCCGGAGCTCCCAACGACCGAACGATCCAGAATGGGGATATGTGCCTGTTCGACATGGGCGGTGAGTATTACTGCTTC
GCTTCCGACATCACCTGCTCCTTTCCCGCCAACGGCAAGTTCACTGCAGACCAGAAGGCCGTCTATGAGGCAGTGCTGCGGAGCTCCCGT
GCCGTCATGGGTGCCATGAAGCCAGGTGTCTGGTGGCCTGACATGCACCGCCTGGCTGACCGCATCCACCTGGAGGAGCTGGCCCACATG
GGCATCCTGAGCGGCAGCGTGGACGCCATGGTCCAGGCTCACCTGGGGGCCGTGTTTATGCCTCACGGGCTTGGCCACTTCCTGGGCATT
GACGTGCACGACGTGGGAGGCTACCCAGAGGGCGTGGAGCGCATCGACGAGCCCGGCCTGCGGAGCCTGCGCACTGCACGGCACCTGCAG
CCAGGCATGGTGCTCACCGTGGAGCCGGGCATCTACTTCATCGACCACCTCCTGGATGAGGCCCTGGCGGACCCGGCCCGCGCCTCCTTC
CTTAACCGCGAGGTCCTGCAGCGCTTTCGCGGTTTTGGCGGGGTCCGCATCGAGGAGGACGTCGTGGTGACTGACAGCGGCATAGAGCTG
CTGACCTGCGTGCCCCGCACTGTGGAAGAGATTGAAGCATGCATGGCAGGCTGTGACAAGGCCTTTACCCCCTTCTCTGGCCCCAAGTAG
AGCCAGCCAGAAATCCCAGCGCACCTGGGGGCCTGGCCTTGCAACCTCTTTTCGTGATGGGCAGCCTGCTGGTCAGCACTCCAGTAGCGA
GAGACGGCACCCAGAATCAGATCCCAGCTTCGGCATTTGATCAGACCAAACAGTGCTGTTTCCCGGGGAGGAAACACTTTTTTAATTACC
CTTTTGCAGGCTCCCACCTTTAATCTGTTTTATACCTTGCTTATTAAATGAGCGACTTAAAATGATTGAAAATAATGCTGTTCTTTAGTA
GCAACTAAAATGTGTCTTGCTGTCATTTATATTCCTTTTCCCAGGAAAGAAGCATTTCTGATACTTTCTGTCAAAAATCAATATGCAGAA

>In-frame_ENST00000542441_ENST00000397032_TCGA-ZG-A9LZ-01A_URI1_chr19_30462134_+_PEPD_chr19_33904549_length(amino acids)=320AA_start in transcript=297_stop in transcript=1259
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHCLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPN
DRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDA
MVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRF

--------------------------------------------------------------
>In-frame_ENST00000542441_ENST00000436370_TCGA-ZG-A9LZ-01A_URI1_chr19_30462134_+_PEPD_chr19_33904549_length(transcript)=1580nt_BP=449nt
GCGGCCGCCACGCGACGCCTGGCTGGGCCCGCACCGGAGAGGCGTCTCGGTACCTGGCAGGCGGCCTGCTACTCGGAGCCCGCTGCGGGG
CGGCGGCGGCGGGGACATGCACGTGTGAGATGCGGCAGCGGGCGGCGCGGACGCGAACAGCAGCGGCGGCGGCGGGCGCGGCCTCCTGGG
CGCGGGGCGCGCGGTGCCTGAGGGCGGGCGCGCGGGCGCTGGGCAACTGCCGGCCGCGCCGCCTGCGCAGGCGCTGGTTCAGGACTCACA
CGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCTGCC
CTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGTGGTCACTAACTGCCAAGAGAGAATCCAGCATTGC
CTCTTCGAGCACTACTGCTACTCCCGGGGCGGCATGCGCCACAGCTCCTACACCTGCATCTGCGGCAGTGGTGAGAACTCAGCCGTGCTA
CACTACGGACACGCCGGAGCTCCCAACGACCGAACGATCCAGAATGGGGATATGTGCCTGTTCGACATGGGCGGTGAGTATTACTGCTTC
GCTTCCGACATCACCTGCTCCTTTCCCGCCAACGGCAAGTTCACTGCAGACCAGAAGGCCGTCTATGAGGCAGTGCTGCGGAGCTCCCGT
GCCGTCATGGGTGCCATGAAGCCAGGTGTCTGGTGGCCTGACATGCACCGCCTGGCTGACCGCATCCACCTGGAGGAGCTGGCCCACATG
GGCATCCTGAGCGGCAGCGTGGACGCCATGGTCCAGGCTCACCTGGGGGCCGTGTTTATGCCTCACGGGCTTGGCCACTTCCTGGGCATT
GACGTGCACGACGTGGGAGGCTACCCAGAGGGCGTGGAGCGCATCGACGAGCCCGGCCTGCGGAGCCTGCGCACTGCACGGCACCTGCAG
CCAGGCATGGTGCTCACCGTGGAGCCGGGCATCTACTTCATCGACCACCTCCTGGATGAGGCCCTGGCGGACCCGGCCCGCGCCTCCTTC
CTTAACCGCGAGGTCCTGCAGCGCTTTCGCGGTTTTGGCGGGGTCCGCATCGAGGAGGACGTCGTGGTGACTGACAGCGGCATAGAGCTG
CTGACCTGCGTGCCCCGCACTGTGGAAGAGATTGAAGCATGCATGGCAGGCTGTGACAAGGCCTTTACCCCCTTCTCTGGCCCCAAGTAG
AGCCAGCCAGAAATCCCAGCGCACCTGGGGGCCTGGCCTTGCAACCTCTTTTCGTGATGGGCAGCCTGCTGGTCAGCACTCCAGTAGCGA
GAGACGGCACCCAGAATCAGATCCCAGCTTCGGCATTTGATCAGACCAAACAGTGCTGTTTCCCGGGGAGGAAACACTTTTTTAATTACC
CTTTTGCAGGCTCCCACCTTTAATCTGTTTTATACCTTGCTTATTAAATGAGCGACTTAAAATGATTGAAAATAATGCTGTTCTTTAGTA

>In-frame_ENST00000542441_ENST00000436370_TCGA-ZG-A9LZ-01A_URI1_chr19_30462134_+_PEPD_chr19_33904549_length(amino acids)=320AA_start in transcript=297_stop in transcript=1259
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHCLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPN
DRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDA
MVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRF

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Fusion Gene PPI Analysis for URI1-PEPD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for URI1-PEPD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for URI1-PEPD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneURI1C0007097Carcinoma1CTD_human
HgeneURI1C0027659Neoplasms, Experimental1CTD_human
HgeneURI1C0205696Anaplastic carcinoma1CTD_human
HgeneURI1C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneURI1C0205698Undifferentiated carcinoma1CTD_human
HgeneURI1C0205699Carcinomatosis1CTD_human
HgeneURI1C0919267ovarian neoplasm1CTD_human
HgeneURI1C1140680Malignant neoplasm of ovary1CTD_human
TgenePEPDC0268532Deficiency of prolidase9CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgenePEPDC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgenePEPDC0019209Hepatomegaly1CTD_human
TgenePEPDC0035242Respiratory Tract Diseases1CTD_human
TgenePEPDC0037299Skin Ulcer1CTD_human
TgenePEPDC0038002Splenomegaly1CTD_human
TgenePEPDC0353676Organophosphorus Poisoning1CTD_human
TgenePEPDC0700359Organophosphate poisoning1CTD_human
TgenePEPDC3494247Organothiophosphonate Poisoning1CTD_human
TgenePEPDC3494248Organothiophosphate Poisoning1CTD_human
TgenePEPDC3714514Infection1CTD_human