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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:URI1-XRCC1 (FusionGDB2 ID:96429)

Fusion Gene Summary for URI1-XRCC1

check button Fusion gene summary
Fusion gene informationFusion gene name: URI1-XRCC1
Fusion gene ID: 96429
HgeneTgene
Gene symbol

URI1

XRCC1

Gene ID

8725

7515

Gene nameURI1 prefoldin like chaperoneX-ray repair cross complementing 1
SynonymsC19orf2|NNX3|PPP1R19|RMP|URIRCC|SCAR26
Cytomap

19q12

19q13.31

Type of geneprotein-codingprotein-coding
Descriptionunconventional prefoldin RPB5 interactor 1RNA polymerase II subunit 5-mediating proteinRPB5-mediating proteinprotein phosphatase 1, regulatory subunit 19DNA repair protein XRCC1X-ray repair complementing defective repair in Chinese hamster cells 1X-ray repair cross-complementing protein 1
Modification date2020031320200329
UniProtAcc

O94763

.
Ensembl transtripts involved in fusion geneENST00000360605, ENST00000542441, 
ENST00000392271, ENST00000312051, 
ENST00000574176, 		ENST00000262887, 
ENST00000543982, 
Fusion gene scores* DoF score30 X 13 X 12=46804 X 4 X 4=64
# samples 405
** MAII scorelog2(40/4680*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: URI1 [Title/Abstract] AND XRCC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointURI1(30433571)-XRCC1(44065172), # samples:3
Anticipated loss of major functional domain due to fusion event.URI1-XRCC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneURI1

GO:0000122

negative regulation of transcription by RNA polymerase II

12737519|15367675|21730289

HgeneURI1

GO:0001558

regulation of cell growth

21730289

HgeneURI1

GO:0071363

cellular response to growth factor stimulus

17936702

HgeneURI1

GO:0071383

cellular response to steroid hormone stimulus

21730289

TgeneXRCC1

GO:0033194

response to hydroperoxide

28002403


check buttonFusion gene breakpoints across URI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across XRCC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1558-01AURI1chr19

30433571

+XRCC1chr19

44065172

-
ChimerDB4OVTCGA-24-1558URI1chr19

30433571

+XRCC1chr19

44065172

-
ChimerDB4OVTCGA-24-1558URI1chr19

30433571

+XRCC1chr19

44058956

-
ChimerDB4OVTCGA-24-1558-01AURI1chr19

30433571

+XRCC1chr19

44065172

-


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Fusion Gene ORF analysis for URI1-XRCC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000360605ENST00000262887URI1chr19

30433571

+XRCC1chr19

44065172

-
intron-3CDSENST00000360605ENST00000543982URI1chr19

30433571

+XRCC1chr19

44065172

-
In-frameENST00000542441ENST00000262887URI1chr19

30433571

+XRCC1chr19

44065172

-
In-frameENST00000542441ENST00000543982URI1chr19

30433571

+XRCC1chr19

44065172

-
5UTR-3CDSENST00000392271ENST00000262887URI1chr19

30433571

+XRCC1chr19

44065172

-
5UTR-3CDSENST00000392271ENST00000543982URI1chr19

30433571

+XRCC1chr19

44065172

-
Frame-shiftENST00000312051ENST00000262887URI1chr19

30433571

+XRCC1chr19

44065172

-
Frame-shiftENST00000312051ENST00000543982URI1chr19

30433571

+XRCC1chr19

44065172

-
intron-3CDSENST00000574176ENST00000262887URI1chr19

30433571

+XRCC1chr19

44065172

-
intron-3CDSENST00000574176ENST00000543982URI1chr19

30433571

+XRCC1chr19

44065172

-
intron-3CDSENST00000360605ENST00000262887URI1chr19

30433571

+XRCC1chr19

44058956

-
intron-3CDSENST00000360605ENST00000543982URI1chr19

30433571

+XRCC1chr19

44058956

-
In-frameENST00000542441ENST00000262887URI1chr19

30433571

+XRCC1chr19

44058956

-
In-frameENST00000542441ENST00000543982URI1chr19

30433571

+XRCC1chr19

44058956

-
5UTR-3CDSENST00000392271ENST00000262887URI1chr19

30433571

+XRCC1chr19

44058956

-
5UTR-3CDSENST00000392271ENST00000543982URI1chr19

30433571

+XRCC1chr19

44058956

-
Frame-shiftENST00000312051ENST00000262887URI1chr19

30433571

+XRCC1chr19

44058956

-
Frame-shiftENST00000312051ENST00000543982URI1chr19

30433571

+XRCC1chr19

44058956

-
intron-3CDSENST00000574176ENST00000262887URI1chr19

30433571

+XRCC1chr19

44058956

-
intron-3CDSENST00000574176ENST00000543982URI1chr19

30433571

+XRCC1chr19

44058956

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000542441URI1chr1930433571+ENST00000262887XRCC1chr1944065172-25244142972171624
ENST00000542441URI1chr1930433571+ENST00000543982XRCC1chr1944065172-22524142972171624
ENST00000542441URI1chr1930433571+ENST00000262887XRCC1chr1944058956-24134142972060587
ENST00000542441URI1chr1930433571+ENST00000543982XRCC1chr1944058956-21414142972060587

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000542441ENST00000262887URI1chr1930433571+XRCC1chr1944065172-0.0065697870.9934302
ENST00000542441ENST00000543982URI1chr1930433571+XRCC1chr1944065172-0.0070240360.99297595
ENST00000542441ENST00000262887URI1chr1930433571+XRCC1chr1944058956-0.0142656980.98573434
ENST00000542441ENST00000543982URI1chr1930433571+XRCC1chr1944058956-0.0157458650.9842541

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Fusion Genomic Features for URI1-XRCC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for URI1-XRCC1


check button Go to

FGviewer for the breakpoints of chr19:30433571-chr19:44065172

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
URI1

O94763

.
FUNCTION: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneXRCC1chr19:30433571chr19:44058956ENST00000262887217315_40385.0634.0DomainBRCT 1
TgeneXRCC1chr19:30433571chr19:44058956ENST00000262887217538_62985.0634.0DomainBRCT 2
TgeneXRCC1chr19:30433571chr19:44065172ENST00000262887117315_40348.0634.0DomainBRCT 1
TgeneXRCC1chr19:30433571chr19:44065172ENST00000262887117538_62948.0634.0DomainBRCT 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneURI1chr19:30433571chr19:44058956ENST00000360605+111299_3110476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr19:44058956ENST00000360605+111314_3210476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr19:44058956ENST00000392271+111299_3110460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr19:44058956ENST00000392271+111314_3210460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr19:44058956ENST00000542441+111299_31139.0536.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr19:44058956ENST00000542441+111314_32139.0536.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr19:44065172ENST00000360605+111299_3110476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr19:44065172ENST00000360605+111314_3210476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr19:44065172ENST00000392271+111299_3110460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr19:44065172ENST00000392271+111314_3210460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr19:44065172ENST00000542441+111299_31139.0536.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr19:44065172ENST00000542441+111314_32139.0536.0Compositional biasNote=Poly-Asp


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Fusion Gene Sequence for URI1-XRCC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000542441_ENST00000262887_TCGA-24-1558-01A_URI1_chr19_30433571_+_XRCC1_chr19_44065172_length(transcript)=2524nt_BP=414nt
GCGGCCGCCACGCGACGCCTGGCTGGGCCCGCACCGGAGAGGCGTCTCGGTACCTGGCAGGCGGCCTGCTACTCGGAGCCCGCTGCGGGG
CGGCGGCGGCGGGGACATGCACGTGTGAGATGCGGCAGCGGGCGGCGCGGACGCGAACAGCAGCGGCGGCGGCGGGCGCGGCCTCCTGGG
CGCGGGGCGCGCGGTGCCTGAGGGCGGGCGCGCGGGCGCTGGGCAACTGCCGGCCGCGCCGCCTGCGCAGGCGCTGGTTCAGGACTCACA
CGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCTGCC
CTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGTTGGAGAAGGAGGAGCAGATACACAGTGTGGACATT
GGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGAGCAAGACTATGAGGTCCTTCTGGTCACC
TCATCTTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCCGGGCAGCC
GCCGAGAAGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCAT
AGCCCCCCAGACAAAGATGAGGCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAG
AGCGCCAACTCTCTGAGGCCGGGGGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGC
TATGCAGCTGCTACCCTCCAGGCTTCTAGTGCTGCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGCCCCAGGAG
TCTCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAAAGAAGACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCC
AAGAGACCTAAATTGCCAGCTCCAACTCGTACCCCAGCCACAGCCCCAGTCCCTGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGA
GGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGGGAAGATCCTTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTC
CAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGGCCAGACTGGACCCGGGACAGCACGCACCTC
ATCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGAGTGGGTGCTGGACTGTCAC
CGCATGCGTCGGCGGCTGCCCTCCCAGAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGGC
AGCGGAGATGAAGCCCCCAAGCTTCCTCAGAAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAG
CCCCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACATTGAGGGGGTACAGTCAGAAGGACAGGACAAT
GGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAAT
GGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCA
GATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAAT
GGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGAC
AACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTG
CCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTC
TCATCCAAGAGTCTCCCAAAACTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTAGAGAAGGA
ACTCTTTGTCTCTTCTGCTTGGCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCAACTT
TTTCTGGCCCTCTGAGCCACACCTGTATCTTGGCTGTCCCTTTGTGGCTGGAGGCCTGGGTACCCATGAGGCTTGTCTCTCTCCTGAAGC

>In-frame_ENST00000542441_ENST00000262887_TCGA-24-1558-01A_URI1_chr19_30433571_+_XRCC1_chr19_44065172_length(amino acids)=624AA_start in transcript=297_stop in transcript=2171
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSES
RSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDESANSLRPGA
LFFSRINKTSPVTASDPAGPSYAAATLQASSAASSASPVSRAIGSTSKPQESPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPT
RTPATAPVPARAQGAVTGKPRGEGTEPRRPRAGPEELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPK
YSQVLGLGGRIVRKEWVLDCHRMRRRLPSQRYLMAGPGSSSEEDEASHSGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQKPPTPEETKA
ASPVLQEDIDIEGVQSEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFF

--------------------------------------------------------------
>In-frame_ENST00000542441_ENST00000543982_TCGA-24-1558-01A_URI1_chr19_30433571_+_XRCC1_chr19_44065172_length(transcript)=2252nt_BP=414nt
GCGGCCGCCACGCGACGCCTGGCTGGGCCCGCACCGGAGAGGCGTCTCGGTACCTGGCAGGCGGCCTGCTACTCGGAGCCCGCTGCGGGG
CGGCGGCGGCGGGGACATGCACGTGTGAGATGCGGCAGCGGGCGGCGCGGACGCGAACAGCAGCGGCGGCGGCGGGCGCGGCCTCCTGGG
CGCGGGGCGCGCGGTGCCTGAGGGCGGGCGCGCGGGCGCTGGGCAACTGCCGGCCGCGCCGCCTGCGCAGGCGCTGGTTCAGGACTCACA
CGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCTGCC
CTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGTTGGAGAAGGAGGAGCAGATACACAGTGTGGACATT
GGGAATGATGGCTCAGCTTTCGTGGAGGTGCTGGTGGGCAGTTCAGCTGGAGGCGCTGGGGAGCAAGACTATGAGGTCCTTCTGGTCACC
TCATCTTTCATGTCCCCTTCCGAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCCGGGCAGCC
GCCGAGAAGCGCTGGGACCGGGTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCAT
AGCCCCCCAGACAAAGATGAGGCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAG
AGCGCCAACTCTCTGAGGCCGGGGGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGC
TATGCAGCTGCTACCCTCCAGGCTTCTAGTGCTGCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGCCCCAGGAG
TCTCCCAAAGGGAAGAGGAAGTTGGATTTGAACCAAGAAGAAAAGAAGACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCC
AAGAGACCTAAATTGCCAGCTCCAACTCGTACCCCAGCCACAGCCCCAGTCCCTGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGA
GGAGAAGGCACCGAGCCCAGACGACCCCGAGCTGGCCCAGAGGAGCTGGGGAAGATCCTTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTC
CAGAACCCCTTCCGCTCCGAGCTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGGCCAGACTGGACCCGGGACAGCACGCACCTC
ATCTGTGCCTTTGCCAACACCCCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGAGTGGGTGCTGGACTGTCAC
CGCATGCGTCGGCGGCTGCCCTCCCAGAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGGC
AGCGGAGATGAAGCCCCCAAGCTTCCTCAGAAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAG
CCCCCAACCCCTGAAGAGACCAAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACATTGAGGGGGTACAGTCAGAAGGACAGGACAAT
GGGGCGGAAGATTCTGGGGACACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAAT
GGGGAAGACCCGTATGCAGGCTCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCA
GATTTCTTCCAGGGCAAGCACTTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAAT
GGGGAGCTCGAGGACAATATGAGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGAC
AACCCCTCCCTGGCATTCGTTCGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTG
CCGCAAGCCTGAAGTATGTGCTATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTC

>In-frame_ENST00000542441_ENST00000543982_TCGA-24-1558-01A_URI1_chr19_30433571_+_XRCC1_chr19_44065172_length(amino acids)=624AA_start in transcript=297_stop in transcript=2171
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSES
RSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDESANSLRPGA
LFFSRINKTSPVTASDPAGPSYAAATLQASSAASSASPVSRAIGSTSKPQESPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPT
RTPATAPVPARAQGAVTGKPRGEGTEPRRPRAGPEELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPK
YSQVLGLGGRIVRKEWVLDCHRMRRRLPSQRYLMAGPGSSSEEDEASHSGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQKPPTPEETKA
ASPVLQEDIDIEGVQSEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFF

--------------------------------------------------------------
>In-frame_ENST00000542441_ENST00000262887_TCGA-24-1558_URI1_chr19_30433571_+_XRCC1_chr19_44058956_length(transcript)=2413nt_BP=414nt
GCGGCCGCCACGCGACGCCTGGCTGGGCCCGCACCGGAGAGGCGTCTCGGTACCTGGCAGGCGGCCTGCTACTCGGAGCCCGCTGCGGGG
CGGCGGCGGCGGGGACATGCACGTGTGAGATGCGGCAGCGGGCGGCGCGGACGCGAACAGCAGCGGCGGCGGCGGGCGCGGCCTCCTGGG
CGCGGGGCGCGCGGTGCCTGAGGGCGGGCGCGCGGGCGCTGGGCAACTGCCGGCCGCGCCGCCTGCGCAGGCGCTGGTTCAGGACTCACA
CGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCTGCC
CTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGTCCTTCTGGTCACCTCATCTTTCATGTCCCCTTCC
GAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCCGGGCAGCCGCCGAGAAGCGCTGGGACCGG
GTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCATAGCCCCCCAGACAAAGATGAG
GCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCTCTGAGGCCG
GGGGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGCTATGCAGCTGCTACCCTCCAG
GCTTCTAGTGCTGCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGCCCCAGGAGTCTCCCAAAGGGAAGAGGAAG
TTGGATTTGAACCAAGAAGAAAAGAAGACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATTGCCAGCT
CCAACTCGTACCCCAGCCACAGCCCCAGTCCCTGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGA
CGACCCCGAGCTGGCCCAGAGGAGCTGGGGAAGATCCTTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAG
CTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGGCCAGACTGGACCCGGGACAGCACGCACCTCATCTGTGCCTTTGCCAACACC
CCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGAGTGGGTGCTGGACTGTCACCGCATGCGTCGGCGGCTGCCC
TCCCAGAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGGCAGCGGAGATGAAGCCCCCAAG
CTTCCTCAGAAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAGCCCCCAACCCCTGAAGAGACC
AAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACATTGAGGGGGTACAGTCAGAAGGACAGGACAATGGGGCGGAAGATTCTGGGGAC
ACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGGC
TCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCAC
TTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGAGCTCGAGGACAATATG
AGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGACAACCCCTCCCTGGCATTCGTT
CGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTGC
TATACACACACACACACACACACACACACACACACACACACGATGCATTTAATAAAGATGAGTTGGTTCTCATCCAAGAGTCTCCCAAAA
CTCTAAGAGGCTCCCTGGGACCTGGGGAAGAATGCTGGGCACCTCCGTCAGAGATCTGGTAGAGAAGGAACTCTTTGTCTCTTCTGCTTG
GCCCCTTATCCCTGTGTTGGCAAGAGGCAGGGAACTGGGAATCTGACCCTCAGCACTGCCCCTCAACTTTTTCTGGCCCTCTGAGCCACA

>In-frame_ENST00000542441_ENST00000262887_TCGA-24-1558_URI1_chr19_30433571_+_XRCC1_chr19_44058956_length(amino acids)=587AA_start in transcript=297_stop in transcript=2060
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPY
SKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDESANSLRPGALFFSRINKTSPVTASDPAGPSYAAATLQASSAASSAS
PVSRAIGSTSKPQESPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPTRTPATAPVPARAQGAVTGKPRGEGTEPRRPRAGPEEL
GKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSQRYLMAGP
GSSSEEDEASHSGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQKPPTPEETKAASPVLQEDIDIEGVQSEGQDNGAEDSGDTEDELRRVA
EQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDNMSDRVQFVIT

--------------------------------------------------------------
>In-frame_ENST00000542441_ENST00000543982_TCGA-24-1558_URI1_chr19_30433571_+_XRCC1_chr19_44058956_length(transcript)=2141nt_BP=414nt
GCGGCCGCCACGCGACGCCTGGCTGGGCCCGCACCGGAGAGGCGTCTCGGTACCTGGCAGGCGGCCTGCTACTCGGAGCCCGCTGCGGGG
CGGCGGCGGCGGGGACATGCACGTGTGAGATGCGGCAGCGGGCGGCGCGGACGCGAACAGCAGCGGCGGCGGCGGGCGCGGCCTCCTGGG
CGCGGGGCGCGCGGTGCCTGAGGGCGGGCGCGCGGGCGCTGGGCAACTGCCGGCCGCGCCGCCTGCGCAGGCGCTGGTTCAGGACTCACA
CGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCTGCC
CTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGTCCTTCTGGTCACCTCATCTTTCATGTCCCCTTCC
GAGAGCCGCAGTGGCTCAAACCCCAACCGCGTTCGCATGTTTGGGCCTGACAAGCTGGTCCGGGCAGCCGCCGAGAAGCGCTGGGACCGG
GTCAAAATTGTTTGCAGCCAGCCCTACAGCAAGGACTCCCCCTTTGGCTTGAGTTTTGTACGGTTTCATAGCCCCCCAGACAAAGATGAG
GCAGAGGCCCCGTCCCAGAAGGTGACAGTGACCAAGCTTGGCCAGTTCCGTGTGAAGGAGGAGGATGAGAGCGCCAACTCTCTGAGGCCG
GGGGCTCTCTTCTTCAGCCGGATCAACAAGACATCCCCAGTCACAGCCAGCGACCCAGCAGGACCTAGCTATGCAGCTGCTACCCTCCAG
GCTTCTAGTGCTGCCTCCTCAGCCTCTCCAGTCTCCAGGGCCATAGGCAGCACCTCCAAGCCCCAGGAGTCTCCCAAAGGGAAGAGGAAG
TTGGATTTGAACCAAGAAGAAAAGAAGACCCCCAGCAAACCACCAGCCCAGCTGTCGCCATCTGTTCCCAAGAGACCTAAATTGCCAGCT
CCAACTCGTACCCCAGCCACAGCCCCAGTCCCTGCCCGAGCACAGGGGGCAGTGACAGGCAAACCCCGAGGAGAAGGCACCGAGCCCAGA
CGACCCCGAGCTGGCCCAGAGGAGCTGGGGAAGATCCTTCAGGGTGTGGTAGTGGTGCTGAGTGGCTTCCAGAACCCCTTCCGCTCCGAG
CTGCGAGATAAGGCCCTAGAGCTTGGGGCCAAGTATCGGCCAGACTGGACCCGGGACAGCACGCACCTCATCTGTGCCTTTGCCAACACC
CCCAAGTACAGCCAGGTCCTAGGCCTGGGAGGCCGCATCGTGCGTAAGGAGTGGGTGCTGGACTGTCACCGCATGCGTCGGCGGCTGCCC
TCCCAGAGGTACCTCATGGCAGGGCCAGGTTCCAGCAGTGAGGAGGATGAGGCCTCTCACAGCGGTGGCAGCGGAGATGAAGCCCCCAAG
CTTCCTCAGAAGCAACCCCAGACCAAAACCAAGCCCACTCAGGCAGCTGGACCCAGCTCACCCCAGAAGCCCCCAACCCCTGAAGAGACC
AAAGCAGCCTCACCAGTGCTCCAGGAAGATATAGACATTGAGGGGGTACAGTCAGAAGGACAGGACAATGGGGCGGAAGATTCTGGGGAC
ACAGAGGATGAGCTGAGGAGGGTGGCAGAGCAGAAGGAACACAGACTGCCCCCTGGCCAGGAGGAGAATGGGGAAGACCCGTATGCAGGC
TCCACGGATGAGAACACGGACAGTGAGGAACACCAGGAGCCTCCTGATCTGCCAGTCCCTGAGCTCCCAGATTTCTTCCAGGGCAAGCAC
TTCTTTCTTTACGGGGAGTTCCCTGGGGACGAGCGGCGGAAACTCATCCGATACGTCACAGCCTTCAATGGGGAGCTCGAGGACAATATG
AGTGACCGGGTTCAGTTTGTGATCACAGCACAGGAATGGGATCCCAGCTTTGAGGAGGCCCTGATGGACAACCCCTCCCTGGCATTCGTT
CGTCCCCGATGGATCTACAGTTGCAATGAGAAGCAGAAGTTACTTCCTCACCAGCTCTATGGGGTGGTGCCGCAAGCCTGAAGTATGTGC

>In-frame_ENST00000542441_ENST00000543982_TCGA-24-1558_URI1_chr19_30433571_+_XRCC1_chr19_44058956_length(amino acids)=587AA_start in transcript=297_stop in transcript=2060
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPY
SKDSPFGLSFVRFHSPPDKDEAEAPSQKVTVTKLGQFRVKEEDESANSLRPGALFFSRINKTSPVTASDPAGPSYAAATLQASSAASSAS
PVSRAIGSTSKPQESPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLPAPTRTPATAPVPARAQGAVTGKPRGEGTEPRRPRAGPEEL
GKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRMRRRLPSQRYLMAGP
GSSSEEDEASHSGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQKPPTPEETKAASPVLQEDIDIEGVQSEGQDNGAEDSGDTEDELRRVA
EQKEHRLPPGQEENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYVTAFNGELEDNMSDRVQFVIT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for URI1-XRCC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for URI1-XRCC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for URI1-XRCC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneURI1C0007097Carcinoma1CTD_human
HgeneURI1C0027659Neoplasms, Experimental1CTD_human
HgeneURI1C0205696Anaplastic carcinoma1CTD_human
HgeneURI1C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneURI1C0205698Undifferentiated carcinoma1CTD_human
HgeneURI1C0205699Carcinomatosis1CTD_human
HgeneURI1C0919267ovarian neoplasm1CTD_human
HgeneURI1C1140680Malignant neoplasm of ovary1CTD_human
TgeneXRCC1C0033578Prostatic Neoplasms3CTD_human
TgeneXRCC1C0376358Malignant neoplasm of prostate3CTD_human
TgeneXRCC1C0025500Mesothelioma2CTD_human
TgeneXRCC1C1449861Micronuclei, Chromosome-Defective2CTD_human
TgeneXRCC1C1449862Micronuclei, Genotoxicant-Induced2CTD_human
TgeneXRCC1C0005612Birth Weight1CTD_human
TgeneXRCC1C0017638Glioma1CTD_human
TgeneXRCC1C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneXRCC1C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneXRCC1C0024623Malignant neoplasm of stomach1CTD_human
TgeneXRCC1C0028797Occupational Diseases1CTD_human
TgeneXRCC1C0036341Schizophrenia1PSYGENET
TgeneXRCC1C0038356Stomach Neoplasms1CTD_human
TgeneXRCC1C0038362Stomatitis1CTD_human
TgeneXRCC1C0041834Erythema1CTD_human
TgeneXRCC1C0259783mixed gliomas1CTD_human
TgeneXRCC1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneXRCC1C0555198Malignant Glioma1CTD_human
TgeneXRCC1C1568868Oral Mucositis1CTD_human
TgeneXRCC1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneXRCC1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneXRCC1C4539948SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 261GENOMICS_ENGLAND;UNIPROT