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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:USP24-DHCR24 (FusionGDB2 ID:96623) |
Fusion Gene Summary for USP24-DHCR24 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP24-DHCR24 | Fusion gene ID: 96623 | Hgene | Tgene | Gene symbol | USP24 | DHCR24 | Gene ID | 23358 | 1718 |
| Gene name | ubiquitin specific peptidase 24 | 24-dehydrocholesterol reductase | |
| Synonyms | - | DCE|Nbla03646|SELADIN1|seladin-1 | |
| Cytomap | 1p32.3 | 1p32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 24deubiquitinating enzyme 24ubiquitin specific protease 24ubiquitin thioesterase 24ubiquitin thiolesterase 24ubiquitin-specific processing protease 24 | delta(24)-sterol reductase3 beta-hydroxysterol delta 24-reductasedesmosterol-to-cholesterol enzymediminuto/dwarf1 homologseladin 1selective AD indicator 1 | |
| Modification date | 20200313 | 20200320 | |
| UniProtAcc | . | Q15392 | |
| Ensembl transtripts involved in fusion gene | ENST00000294383, ENST00000407756, ENST00000484447, | ENST00000371269, ENST00000537443, ENST00000535035, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 9 X 10 X 4=360 |
| # samples | 5 | 9 | |
| ** MAII score | log2(5/50*10)=0 | log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: USP24 [Title/Abstract] AND DHCR24 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | USP24(55637229)-DHCR24(55337286), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DHCR24 | GO:0043066 | negative regulation of apoptotic process | 15688385 |
| Tgene | DHCR24 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 11007892 |
| Fusion gene breakpoints across USP24 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across DHCR24 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-4W-AA9T-01A | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - |
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Fusion Gene ORF analysis for USP24-DHCR24 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000294383 | ENST00000371269 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - |
| In-frame | ENST00000294383 | ENST00000537443 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - |
| In-frame | ENST00000294383 | ENST00000535035 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - |
| In-frame | ENST00000407756 | ENST00000371269 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - |
| In-frame | ENST00000407756 | ENST00000537443 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - |
| In-frame | ENST00000407756 | ENST00000535035 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - |
| intron-3CDS | ENST00000484447 | ENST00000371269 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - |
| intron-3CDS | ENST00000484447 | ENST00000537443 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - |
| intron-3CDS | ENST00000484447 | ENST00000535035 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000294383 | USP24 | chr1 | 55637229 | - | ENST00000371269 | DHCR24 | chr1 | 55337286 | - | 4364 | 825 | 0 | 1763 | 587 |
| ENST00000294383 | USP24 | chr1 | 55637229 | - | ENST00000537443 | DHCR24 | chr1 | 55337286 | - | 2130 | 825 | 0 | 1619 | 539 |
| ENST00000294383 | USP24 | chr1 | 55637229 | - | ENST00000535035 | DHCR24 | chr1 | 55337286 | - | 2087 | 825 | 0 | 1763 | 587 |
| ENST00000407756 | USP24 | chr1 | 55637229 | - | ENST00000371269 | DHCR24 | chr1 | 55337286 | - | 4028 | 489 | 0 | 1427 | 475 |
| ENST00000407756 | USP24 | chr1 | 55637229 | - | ENST00000537443 | DHCR24 | chr1 | 55337286 | - | 1794 | 489 | 0 | 1283 | 427 |
| ENST00000407756 | USP24 | chr1 | 55637229 | - | ENST00000535035 | DHCR24 | chr1 | 55337286 | - | 1751 | 489 | 0 | 1427 | 475 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000294383 | ENST00000371269 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - | 0.000989588 | 0.99901044 |
| ENST00000294383 | ENST00000537443 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - | 0.002325859 | 0.99767417 |
| ENST00000294383 | ENST00000535035 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - | 0.002791849 | 0.9972082 |
| ENST00000407756 | ENST00000371269 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - | 0.00155187 | 0.99844813 |
| ENST00000407756 | ENST00000537443 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - | 0.004739047 | 0.995261 |
| ENST00000407756 | ENST00000535035 | USP24 | chr1 | 55637229 | - | DHCR24 | chr1 | 55337286 | - | 0.003854944 | 0.996145 |
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Fusion Genomic Features for USP24-DHCR24 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for USP24-DHCR24 |
| Go to FGviewer for the breakpoints of chr1:55637229-chr1:55337286 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | DHCR24 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:25637936, PubMed:22178193). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892). {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:21671375, ECO:0000269|PubMed:22010141, ECO:0000269|PubMed:22178193, ECO:0000269|PubMed:25637936}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | USP24 | chr1:55637229 | chr1:55337286 | ENST00000294383 | - | 5 | 68 | 47_94 | 275.0 | 2621.0 | Compositional bias | Note=Gly-rich |
| Hgene | USP24 | chr1:55637229 | chr1:55337286 | ENST00000294383 | - | 5 | 68 | 3_44 | 275.0 | 2621.0 | Domain | UBA |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | USP24 | chr1:55637229 | chr1:55337286 | ENST00000294383 | - | 5 | 68 | 1035_1062 | 275.0 | 2621.0 | Compositional bias | Note=Ser-rich |
| Hgene | USP24 | chr1:55637229 | chr1:55337286 | ENST00000294383 | - | 5 | 68 | 1132_1164 | 275.0 | 2621.0 | Compositional bias | Note=Ser-rich |
| Hgene | USP24 | chr1:55637229 | chr1:55337286 | ENST00000294383 | - | 5 | 68 | 1689_2042 | 275.0 | 2621.0 | Domain | Note=USP |
| Tgene | DHCR24 | chr1:55637229 | chr1:55337286 | ENST00000371269 | 3 | 9 | 58_234 | 204.0 | 517.0 | Domain | FAD-binding PCMH-type | |
| Tgene | DHCR24 | chr1:55637229 | chr1:55337286 | ENST00000371269 | 3 | 9 | 163_175 | 204.0 | 517.0 | Nucleotide binding | FAD | |
| Tgene | DHCR24 | chr1:55637229 | chr1:55337286 | ENST00000371269 | 3 | 9 | 23_31 | 204.0 | 517.0 | Topological domain | Lumenal | |
| Tgene | DHCR24 | chr1:55637229 | chr1:55337286 | ENST00000371269 | 3 | 9 | 53_516 | 204.0 | 517.0 | Topological domain | Cytoplasmic | |
| Tgene | DHCR24 | chr1:55637229 | chr1:55337286 | ENST00000371269 | 3 | 9 | 32_52 | 204.0 | 517.0 | Transmembrane | Helical |
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Fusion Gene Sequence for USP24-DHCR24 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000294383_ENST00000371269_TCGA-4W-AA9T-01A_USP24_chr1_55637229_-_DHCR24_chr1_55337286_length(transcript)=4364nt_BP=825nt ATGGAATCGGAGGAGGAGCAGCACATGACCACGCTGCTGTGCATGGGCTTCTCAGACCCCGCCACCATCCGCAAGGCCCTGCGCCTGGCC AAGAACGACATTAACGAGGCCGTGGCACTGCTCACCAACGAGCGGCCGGGCCTCGACTACGGCGGCTACGAGCCCATGGACAGCGGCGGT GGCCCCAGCCCCGGGCCCGGCGGGGGCCCGCGGGGCGACGGCGGAGGTGACGGCGGCGGCGGCGGCCCCTCCCGCGGCGGGAGCACCGGA GGCGGGGGCGGCTTCGACCCCCCGCCCGCCTACCACGAGGTGGTGGACGCGGAGAAGAATGATGAGAATGGAAACTGCTCAGGGGAAGGA ATTGAATTCCCTACAACAAATTTATATGAACTGGAAAGCCGTGTTTTGACTGATCATTGGTCCATCCCTTACAAGCGAGAAGAATCACTA GGCAAATGCCTGTTGGCATCTACCTACCTAGCAAGACTTGGTCTTTCCGAGTCTGATGAGAATTGTAGAAGGTTTATGGACAGGTGTATG CCTGAAGCATTTAAAAAGCTCCTGACATCAAGTGCTGTTCACAAGTGGGGTACTGAAATTCATGAAGGAATTTACAACATGTTGATGCTA TTAATAGAACTGGTCGCAGAGAGAATAAAACAAGATCCAATTCCCACTGGTCTCCTGGGTGTGCTTACAATGGCTTTCAATCCTGATAAT GAATACCATTTTAAAAACAGAATGAAAGTGTCTCAAAGGAATTGGGCAGAAGTGTTTGGAGAGGGAAATATGTTTGCTGTTTCACCTGTA TCGACTTTCCAAAAGTCCGAAAACTCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACGCTGGGTTTCCTGGTGGCCGCTGAGATC CGCATCATCCCTGCCAAGAAGTACGTCAAGCTGCGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATCTGTGCCAAGTTCACCCACGAGTCC CAGCGGCAGGAGAACCACTTCGTGGAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATGACAGGGGTCATGACAGATGAGGCAGAG CCCAGCAAGCTGAATAGCATTGGCAATTACTACAAGCCGTGGTTCTTTAAGCATGTGGAGAACTATCTGAAGACAAACCGAGAGGGCCTG GAGTACATTCCCTTGAGACACTACTACCACCGCCACACGCGCAGCATCTTCTGGGAGCTCCAGGACATTATCCCCTTTGGCAACAACCCC ATCTTCCGCTACCTCTTTGGCTGGATGGTGCCTCCCAAGATCTCCCTCCTGAAGCTGACCCAGGGTGAGACCCTGCGCAAGCTGTACGAG CAGCACCACGTGGTGCAGGACATGCTGGTGCCCATGAAGTGCCTGCAGCAGGCCCTGCACACCTTCCAAAACGACATCCACGTCTACCCC ATCTGGCTGTGTCCGTTCATCCTGCCCAGCCAGCCAGGCCTAGTGCACCCCAAAGGAAATGAGGCAGAGCTCTACATCGACATTGGAGCA TATGGGGAGCCGCGTGTGAAACACTTTGAAGCCAGGTCCTGCATGAGGCAGCTGGAGAAGTTTGTCCGCAGCGTGCATGGCTTCCAGATG CTGTATGCCGACTGCTACATGAACCGGGAGGAGTTCTGGGAGATGTTTGATGGCTCCTTGTACCACAAGCTGCGAGAGAAGCTGGGTTGC CAGGACGCCTTCCCCGAGGTGTACGACAAGATCTGCAAGGCCGCCAGGCACTGAGCTGGAGCCCGCCTGGAGAGACAGACACGTGTGAGT GGTCAGGCATCTTCCCTTCACTCAAGCTTGGCTGCTTTCCTAGATCCACACTTTCAAAGAGAAACCCCTCCAGAACTCCCACCCTGACAG CCCAACACCACCTTCCTCCTGGCTTCCAGGGGGCAGCCCAGTGGAATGGAAAGAATGTGGGATTTGGAGTCAGACAAGCCTGAGTCCAGT TCCCCGTTTAGAACTCATTAGCTGTGTGACTCTGGGTGAGTCCCTTAACCCCTCTGAGCCCGGGTCTCTTCATTAGTTGAAAGGGATAGT AATACCTACTTGCAGGTTGTTGTCATCTGAGTTGAGCACTGGTCACATTGAAGGTGCTGGGTAAGTGGTAGCTCTTGTTGCTTCCCGTTC AGCGTCACATCTGCAGTGGAGCCTGAAAAGGCTCCACATTAGGTCACCTGTGCACAGCCATGGCTGGAATGATGAAGGGGATACGCTGGA GTTGCCCTGCCATCGCCTCCATCAGCCAGACGAGGTCCTCACAGGAGAAGGACAGCTCTTCCCCACCCTGGGATCTCAGGAGGGCAGCCA CGGAGTGGGGAGGCCCCAGATGCGCTGTGCCAAAGCCAGGTCCGAGGCCAAAGTTCTCCCTGCCATCCTTGGTGCCGTCCTGCCCCTTCC TCCTTCATGCCTGGGCCTGCAGGCCCACCCCAGCCACCACTGAGTCCACTCGGAGTGCCCTGTGTTCCTGGAGAAGGCATTCCAGGGTTG AATCTTGTCCCAGCCTCAGCCTGGGACACCTAGGTGGAGAGAGTGGTCTCCGCTCTGAATTGGATCCAGGGGACCTGGGCTCATTCTTCT TGGCTCACCAACCCTGCAGGCCTCATCTTTCCCAAAACCCACTTTGTCTTGGTGGGAGTGGGTCCGCGCTGCTCTGCAGCAGGGGCTGGG GAGTGGACAGCATCAGGTGGGAAAGTGGAGTCCACCCTCATGTTTCTGTAGGATTCTCACCGTGGGGCTGGAAGAAAAGAGCATCGACTT GATTTCTCCAACCACTCATCCCTCTTTTTCTTTCTTCCACCACTCCCCACCCCAGCTGTAGTTAATTTCAGTGCCTTACAAATCCTAAGC TCAGAGAAAGTTCCATTTCCGTTCCAGAGGGAAGGGAACCTCCCTAGGTCCTTCCCTGGCTTGTTATAACGCAAAGCTTGGTTGTTTATG CAACTCTATCTTAAGAACTGCCCAGCCTCAGCTGAAAACCCGAATCTGAGAAGGAATTGCGTCATGTAAGGGAAGCTGGAATTAAGGGAG CTGAGCCAGTCATGGTTGTGGCGTGTGAGTCAGGAGACCTAGGTTTCAGCCCCTCTCTACTGTCAGCGAGCTGTGCAACGTGGGCAAGTC ATTGTCCTCTGAGCTGCAGTTTCCTCATCTGTCACATCGCTACAGACAAGACCTCCCTGGAACCCTTCTGATTGTCTTAGACACTGTGGT TGCAAAACCCACGGAAAGCCTCATTTGTGTGGAAAGTCAGAGGAAAAATGATCCAGTGGACACTTGGGGATTATCTGTCATTCAAGATCC TTCCTTCAACCCCAAGGTCAGCTCCCATCTCATTTCCAGAAAGGCTCATACCTGGCTTGCAGGGAAGCATCTGTCTTGTCATTCCAGGTG CCAGAATCCTCTCAGAGTCATTGAAGGGTGTTCACCCATCCCACCCAAGGCTTGGCACACTGCCAGTGTCTTAGCAGGGTCTTGTGAGGG CTGGGGGCATCCAGGCACTCAGAAGGCAAAGGAACCACCCTACCCATTTGGCCTCTGGAGGGGGCAGAAGAAAGAAATAAACCTCATCCT ATATTTTACAAAGCATGTGAATTCTGGCATTAGCTCTCATAGGAGACCCATGTGCTTCCTTGCTCAGTGCAAAACTGATGATTCTACTTG CTGTAGATGAATGGTTAACACGAGCTAGTTAAACAGTGCCATTGTTTTGCCAGTGAAGCCTCCAACCCTAAGCCACTGGGACGGTGGCCA GAGATGCCAGCAGCCTCTGTCGCCCTTAGTCATATAACCAAAATCCAGACCTTATCCACAACCCGGGGCTTGGAAAGGAAGGTATTTTGG AATCACACCCTCCGGTTATGTTGCTCCAGTAAAATCTTGCCTGGAAAGAGGCAGTCTTCTTAGCATGGTGAGCTGAGTTCATGGCTTTTT TTTGTAGCCAGTCCTGTCCCTGGCCATCCATGTGATGGTTTTGGATGGAGTTAAACTTGATGCCAGTGGGCAGTGCATGTGGAAAGTATC AGAGTAAGGCTCTCCCCTCCAGAGCCCTGAGTTTCTTGGCTGCATGAAGGTTTTCTTTAGAATCAGAATTGTAGCCAGTTTCTTTGGCCA GAAGGATGAATACTTGGATATTACTGAAAGGGAGGGGTGGAGATGGGTGTGGCAGTGTATGGTGTGTGATTTTTATTTTCTTCTTTGGTC ATGGGGGCCAAGGAGAAAGGCATGAATCTTCCCTGTCAGGCTCTTACAGCCACAGGCACTGTGTCTACTGTCTGGAAGACATGTCCCCAT >In-frame_ENST00000294383_ENST00000371269_TCGA-4W-AA9T-01A_USP24_chr1_55637229_-_DHCR24_chr1_55337286_length(amino acids)=587AA_start in transcript=0_stop in transcript=1763 MESEEEQHMTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGGPSPGPGGGPRGDGGGDGGGGGPSRGGSTG GGGGFDPPPAYHEVVDAEKNDENGNCSGEGIEFPTTNLYELESRVLTDHWSIPYKREESLGKCLLASTYLARLGLSESDENCRRFMDRCM PEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDPIPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPV STFQKSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAE PSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYE QHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQM -------------------------------------------------------------- >In-frame_ENST00000294383_ENST00000537443_TCGA-4W-AA9T-01A_USP24_chr1_55637229_-_DHCR24_chr1_55337286_length(transcript)=2130nt_BP=825nt ATGGAATCGGAGGAGGAGCAGCACATGACCACGCTGCTGTGCATGGGCTTCTCAGACCCCGCCACCATCCGCAAGGCCCTGCGCCTGGCC AAGAACGACATTAACGAGGCCGTGGCACTGCTCACCAACGAGCGGCCGGGCCTCGACTACGGCGGCTACGAGCCCATGGACAGCGGCGGT GGCCCCAGCCCCGGGCCCGGCGGGGGCCCGCGGGGCGACGGCGGAGGTGACGGCGGCGGCGGCGGCCCCTCCCGCGGCGGGAGCACCGGA GGCGGGGGCGGCTTCGACCCCCCGCCCGCCTACCACGAGGTGGTGGACGCGGAGAAGAATGATGAGAATGGAAACTGCTCAGGGGAAGGA ATTGAATTCCCTACAACAAATTTATATGAACTGGAAAGCCGTGTTTTGACTGATCATTGGTCCATCCCTTACAAGCGAGAAGAATCACTA GGCAAATGCCTGTTGGCATCTACCTACCTAGCAAGACTTGGTCTTTCCGAGTCTGATGAGAATTGTAGAAGGTTTATGGACAGGTGTATG CCTGAAGCATTTAAAAAGCTCCTGACATCAAGTGCTGTTCACAAGTGGGGTACTGAAATTCATGAAGGAATTTACAACATGTTGATGCTA TTAATAGAACTGGTCGCAGAGAGAATAAAACAAGATCCAATTCCCACTGGTCTCCTGGGTGTGCTTACAATGGCTTTCAATCCTGATAAT GAATACCATTTTAAAAACAGAATGAAAGTGTCTCAAAGGAATTGGGCAGAAGTGTTTGGAGAGGGAAATATGTTTGCTGTTTCACCTGTA TCGACTTTCCAAAAGTCCGAAAACTCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACGCTGGGTTTCCTGGTGGCCGCTGAGATC CGCATCATCCCTGCCAAGAAGTACGTCAAGCTGCGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATCTGTGCCAAGTTCACCCACGAGTCC CAGCGGCAGGAGAACCACTTCGTGGAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATGACAGGGGTCATGACAGATGAGGCAGAG CCCAGCAAGGACATTATCCCCTTTGGCAACAACCCCATCTTCCGCTACCTCTTTGGCTGGATGGTGCCTCCCAAGATCTCCCTCCTGAAG CTGACCCAGGGTGAGACCCTGCGCAAGCTGTACGAGCAGCACCACGTGGTGCAGGACATGCTGGTGCCCATGAAGTGCCTGCAGCAGGCC CTGCACACCTTCCAAAACGACATCCACGTCTACCCCATCTGGCTGTGTCCGTTCATCCTGCCCAGCCAGCCAGGCCTAGTGCACCCCAAA GGAAATGAGGCAGAGCTCTACATCGACATTGGAGCATATGGGGAGCCGCGTGTGAAACACTTTGAAGCCAGGTCCTGCATGAGGCAGCTG GAGAAGTTTGTCCGCAGCGTGCATGGCTTCCAGATGCTGTATGCCGACTGCTACATGAACCGGGAGGAGTTCTGGGAGATGTTTGATGGC TCCTTGTACCACAAGCTGCGAGAGAAGCTGGGTTGCCAGGACGCCTTCCCCGAGGTGTACGACAAGATCTGCAAGGCCGCCAGGCACTGA GCTGGAGCCCGCCTGGAGAGACAGACACGTGTGAGTGGTCAGGCATCTTCCCTTCACTCAAGCTTGGCTGCTTTCCTAGATCCACACTTT CAAAGAGAAACCCCTCCAGAACTCCCACCCTGACAGCCCAACACCACCTTCCTCCTGGCTTCCAGGGGGCAGCCCAGTGGAATGGAAAGA ATGTGGGATTTGGAGTCAGACAAGCCTGAGTCCAGTTCCCCGTTTAGAACTCATTAGCTGTGTGACTCTGGGTGAGTCCCTTAACCCCTC TGAGCCCGGGTCTCTTCATTAGTTGAAAGGGATAGTAATACCTACTTGCAGGTTGTTGTCATCTGAGTTGAGCACTGGTCACATTGAAGG TGCTGGGTAAGTGGTAGCTCTTGTTGCTTCCCGTTCAGCGTCACATCTGCAGTGGAGCCTGAAAAGGCTCCACATTAGGTCACCTGTGCA >In-frame_ENST00000294383_ENST00000537443_TCGA-4W-AA9T-01A_USP24_chr1_55637229_-_DHCR24_chr1_55337286_length(amino acids)=539AA_start in transcript=0_stop in transcript=1619 MESEEEQHMTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGGPSPGPGGGPRGDGGGDGGGGGPSRGGSTG GGGGFDPPPAYHEVVDAEKNDENGNCSGEGIEFPTTNLYELESRVLTDHWSIPYKREESLGKCLLASTYLARLGLSESDENCRRFMDRCM PEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDPIPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPV STFQKSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAE PSKDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPK -------------------------------------------------------------- >In-frame_ENST00000294383_ENST00000535035_TCGA-4W-AA9T-01A_USP24_chr1_55637229_-_DHCR24_chr1_55337286_length(transcript)=2087nt_BP=825nt ATGGAATCGGAGGAGGAGCAGCACATGACCACGCTGCTGTGCATGGGCTTCTCAGACCCCGCCACCATCCGCAAGGCCCTGCGCCTGGCC AAGAACGACATTAACGAGGCCGTGGCACTGCTCACCAACGAGCGGCCGGGCCTCGACTACGGCGGCTACGAGCCCATGGACAGCGGCGGT GGCCCCAGCCCCGGGCCCGGCGGGGGCCCGCGGGGCGACGGCGGAGGTGACGGCGGCGGCGGCGGCCCCTCCCGCGGCGGGAGCACCGGA GGCGGGGGCGGCTTCGACCCCCCGCCCGCCTACCACGAGGTGGTGGACGCGGAGAAGAATGATGAGAATGGAAACTGCTCAGGGGAAGGA ATTGAATTCCCTACAACAAATTTATATGAACTGGAAAGCCGTGTTTTGACTGATCATTGGTCCATCCCTTACAAGCGAGAAGAATCACTA GGCAAATGCCTGTTGGCATCTACCTACCTAGCAAGACTTGGTCTTTCCGAGTCTGATGAGAATTGTAGAAGGTTTATGGACAGGTGTATG CCTGAAGCATTTAAAAAGCTCCTGACATCAAGTGCTGTTCACAAGTGGGGTACTGAAATTCATGAAGGAATTTACAACATGTTGATGCTA TTAATAGAACTGGTCGCAGAGAGAATAAAACAAGATCCAATTCCCACTGGTCTCCTGGGTGTGCTTACAATGGCTTTCAATCCTGATAAT GAATACCATTTTAAAAACAGAATGAAAGTGTCTCAAAGGAATTGGGCAGAAGTGTTTGGAGAGGGAAATATGTTTGCTGTTTCACCTGTA TCGACTTTCCAAAAGTCCGAAAACTCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACGCTGGGTTTCCTGGTGGCCGCTGAGATC CGCATCATCCCTGCCAAGAAGTACGTCAAGCTGCGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATCTGTGCCAAGTTCACCCACGAGTCC CAGCGGCAGGAGAACCACTTCGTGGAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATGACAGGGGTCATGACAGATGAGGCAGAG CCCAGCAAGCTGAATAGCATTGGCAATTACTACAAGCCGTGGTTCTTTAAGCATGTGGAGAACTATCTGAAGACAAACCGAGAGGGCCTG GAGTACATTCCCTTGAGACACTACTACCACCGCCACACGCGCAGCATCTTCTGGGAGCTCCAGGACATTATCCCCTTTGGCAACAACCCC ATCTTCCGCTACCTCTTTGGCTGGATGGTGCCTCCCAAGATCTCCCTCCTGAAGCTGACCCAGGGTGAGACCCTGCGCAAGCTGTACGAG CAGCACCACGTGGTGCAGGACATGCTGGTGCCCATGAAGTGCCTGCAGCAGGCCCTGCACACCTTCCAAAACGACATCCACGTCTACCCC ATCTGGCTGTGTCCGTTCATCCTGCCCAGCCAGCCAGGCCTAGTGCACCCCAAAGGAAATGAGGCAGAGCTCTACATCGACATTGGAGCA TATGGGGAGCCGCGTGTGAAACACTTTGAAGCCAGGTCCTGCATGAGGCAGCTGGAGAAGTTTGTCCGCAGCGTGCATGGCTTCCAGATG CTGTATGCCGACTGCTACATGAACCGGGAGGAGTTCTGGGAGATGTTTGATGGCTCCTTGTACCACAAGCTGCGAGAGAAGCTGGGTTGC CAGGACGCCTTCCCCGAGGTGTACGACAAGATCTGCAAGGCCGCCAGGCACTGAGCTGGAGCCCGCCTGGAGAGACAGACACGTGTGAGT GGTCAGGCATCTTCCCTTCACTCAAGCTTGGCTGCTTTCCTAGATCCACACTTTCAAAGAGAAACCCCTCCAGAACTCCCACCCTGACAG CCCAACACCACCTTCCTCCTGGCTTCCAGGGGGCAGCCCAGTGGAATGGAAAGAATGTGGGATTTGGAGTCAGACAAGCCTGAGTCCAGT TCCCCGTTTAGAACTCATTAGCTGTGTGACTCTGGGTGAGTCCCTTAACCCCTCTGAGCCCGGGTCTCTTCATTAGTTGAAAGGGATAGT >In-frame_ENST00000294383_ENST00000535035_TCGA-4W-AA9T-01A_USP24_chr1_55637229_-_DHCR24_chr1_55337286_length(amino acids)=587AA_start in transcript=0_stop in transcript=1763 MESEEEQHMTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGGPSPGPGGGPRGDGGGDGGGGGPSRGGSTG GGGGFDPPPAYHEVVDAEKNDENGNCSGEGIEFPTTNLYELESRVLTDHWSIPYKREESLGKCLLASTYLARLGLSESDENCRRFMDRCM PEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDPIPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPV STFQKSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAE PSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYE QHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQM -------------------------------------------------------------- >In-frame_ENST00000407756_ENST00000371269_TCGA-4W-AA9T-01A_USP24_chr1_55637229_-_DHCR24_chr1_55337286_length(transcript)=4028nt_BP=489nt ATGACCACGCTGCTGTGCATGGGCTTCTCAGACCCCGCCACCATCCGCAAGGCCCTGCGCCTGGCCAAGAACGACATTAACGAGGCCGTG GCACTGCTCACCAACGAGCGGCCGGGCCTCGACTACGGCGGCTACGAGCCCATGGACAGCGGCGGTCTTTCCGAGTCTGATGAGAATTGT AGAAGGTTTATGGACAGGTGTATGCCTGAAGCATTTAAAAAGCTCCTGACATCAAGTGCTGTTCACAAGTGGGGTACTGAAATTCATGAA GGAATTTACAACATGTTGATGCTATTAATAGAACTGGTCGCAGAGAGAATAAAACAAGATCCAATTCCCACTGGTCTCCTGGGTGTGCTT ACAATGGCTTTCAATCCTGATAATGAATACCATTTTAAAAACAGAATGAAAGTGTCTCAAAGGAATTGGGCAGAAGTGTTTGGAGAGGGA AATATGTTTGCTGTTTCACCTGTATCGACTTTCCAAAAGTCCGAAAACTCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACGCTG GGTTTCCTGGTGGCCGCTGAGATCCGCATCATCCCTGCCAAGAAGTACGTCAAGCTGCGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATC TGTGCCAAGTTCACCCACGAGTCCCAGCGGCAGGAGAACCACTTCGTGGAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATGACA GGGGTCATGACAGATGAGGCAGAGCCCAGCAAGCTGAATAGCATTGGCAATTACTACAAGCCGTGGTTCTTTAAGCATGTGGAGAACTAT CTGAAGACAAACCGAGAGGGCCTGGAGTACATTCCCTTGAGACACTACTACCACCGCCACACGCGCAGCATCTTCTGGGAGCTCCAGGAC ATTATCCCCTTTGGCAACAACCCCATCTTCCGCTACCTCTTTGGCTGGATGGTGCCTCCCAAGATCTCCCTCCTGAAGCTGACCCAGGGT GAGACCCTGCGCAAGCTGTACGAGCAGCACCACGTGGTGCAGGACATGCTGGTGCCCATGAAGTGCCTGCAGCAGGCCCTGCACACCTTC CAAAACGACATCCACGTCTACCCCATCTGGCTGTGTCCGTTCATCCTGCCCAGCCAGCCAGGCCTAGTGCACCCCAAAGGAAATGAGGCA GAGCTCTACATCGACATTGGAGCATATGGGGAGCCGCGTGTGAAACACTTTGAAGCCAGGTCCTGCATGAGGCAGCTGGAGAAGTTTGTC CGCAGCGTGCATGGCTTCCAGATGCTGTATGCCGACTGCTACATGAACCGGGAGGAGTTCTGGGAGATGTTTGATGGCTCCTTGTACCAC AAGCTGCGAGAGAAGCTGGGTTGCCAGGACGCCTTCCCCGAGGTGTACGACAAGATCTGCAAGGCCGCCAGGCACTGAGCTGGAGCCCGC CTGGAGAGACAGACACGTGTGAGTGGTCAGGCATCTTCCCTTCACTCAAGCTTGGCTGCTTTCCTAGATCCACACTTTCAAAGAGAAACC CCTCCAGAACTCCCACCCTGACAGCCCAACACCACCTTCCTCCTGGCTTCCAGGGGGCAGCCCAGTGGAATGGAAAGAATGTGGGATTTG GAGTCAGACAAGCCTGAGTCCAGTTCCCCGTTTAGAACTCATTAGCTGTGTGACTCTGGGTGAGTCCCTTAACCCCTCTGAGCCCGGGTC TCTTCATTAGTTGAAAGGGATAGTAATACCTACTTGCAGGTTGTTGTCATCTGAGTTGAGCACTGGTCACATTGAAGGTGCTGGGTAAGT GGTAGCTCTTGTTGCTTCCCGTTCAGCGTCACATCTGCAGTGGAGCCTGAAAAGGCTCCACATTAGGTCACCTGTGCACAGCCATGGCTG GAATGATGAAGGGGATACGCTGGAGTTGCCCTGCCATCGCCTCCATCAGCCAGACGAGGTCCTCACAGGAGAAGGACAGCTCTTCCCCAC CCTGGGATCTCAGGAGGGCAGCCACGGAGTGGGGAGGCCCCAGATGCGCTGTGCCAAAGCCAGGTCCGAGGCCAAAGTTCTCCCTGCCAT CCTTGGTGCCGTCCTGCCCCTTCCTCCTTCATGCCTGGGCCTGCAGGCCCACCCCAGCCACCACTGAGTCCACTCGGAGTGCCCTGTGTT CCTGGAGAAGGCATTCCAGGGTTGAATCTTGTCCCAGCCTCAGCCTGGGACACCTAGGTGGAGAGAGTGGTCTCCGCTCTGAATTGGATC CAGGGGACCTGGGCTCATTCTTCTTGGCTCACCAACCCTGCAGGCCTCATCTTTCCCAAAACCCACTTTGTCTTGGTGGGAGTGGGTCCG CGCTGCTCTGCAGCAGGGGCTGGGGAGTGGACAGCATCAGGTGGGAAAGTGGAGTCCACCCTCATGTTTCTGTAGGATTCTCACCGTGGG GCTGGAAGAAAAGAGCATCGACTTGATTTCTCCAACCACTCATCCCTCTTTTTCTTTCTTCCACCACTCCCCACCCCAGCTGTAGTTAAT TTCAGTGCCTTACAAATCCTAAGCTCAGAGAAAGTTCCATTTCCGTTCCAGAGGGAAGGGAACCTCCCTAGGTCCTTCCCTGGCTTGTTA TAACGCAAAGCTTGGTTGTTTATGCAACTCTATCTTAAGAACTGCCCAGCCTCAGCTGAAAACCCGAATCTGAGAAGGAATTGCGTCATG TAAGGGAAGCTGGAATTAAGGGAGCTGAGCCAGTCATGGTTGTGGCGTGTGAGTCAGGAGACCTAGGTTTCAGCCCCTCTCTACTGTCAG CGAGCTGTGCAACGTGGGCAAGTCATTGTCCTCTGAGCTGCAGTTTCCTCATCTGTCACATCGCTACAGACAAGACCTCCCTGGAACCCT TCTGATTGTCTTAGACACTGTGGTTGCAAAACCCACGGAAAGCCTCATTTGTGTGGAAAGTCAGAGGAAAAATGATCCAGTGGACACTTG GGGATTATCTGTCATTCAAGATCCTTCCTTCAACCCCAAGGTCAGCTCCCATCTCATTTCCAGAAAGGCTCATACCTGGCTTGCAGGGAA GCATCTGTCTTGTCATTCCAGGTGCCAGAATCCTCTCAGAGTCATTGAAGGGTGTTCACCCATCCCACCCAAGGCTTGGCACACTGCCAG TGTCTTAGCAGGGTCTTGTGAGGGCTGGGGGCATCCAGGCACTCAGAAGGCAAAGGAACCACCCTACCCATTTGGCCTCTGGAGGGGGCA GAAGAAAGAAATAAACCTCATCCTATATTTTACAAAGCATGTGAATTCTGGCATTAGCTCTCATAGGAGACCCATGTGCTTCCTTGCTCA GTGCAAAACTGATGATTCTACTTGCTGTAGATGAATGGTTAACACGAGCTAGTTAAACAGTGCCATTGTTTTGCCAGTGAAGCCTCCAAC CCTAAGCCACTGGGACGGTGGCCAGAGATGCCAGCAGCCTCTGTCGCCCTTAGTCATATAACCAAAATCCAGACCTTATCCACAACCCGG GGCTTGGAAAGGAAGGTATTTTGGAATCACACCCTCCGGTTATGTTGCTCCAGTAAAATCTTGCCTGGAAAGAGGCAGTCTTCTTAGCAT GGTGAGCTGAGTTCATGGCTTTTTTTTGTAGCCAGTCCTGTCCCTGGCCATCCATGTGATGGTTTTGGATGGAGTTAAACTTGATGCCAG TGGGCAGTGCATGTGGAAAGTATCAGAGTAAGGCTCTCCCCTCCAGAGCCCTGAGTTTCTTGGCTGCATGAAGGTTTTCTTTAGAATCAG AATTGTAGCCAGTTTCTTTGGCCAGAAGGATGAATACTTGGATATTACTGAAAGGGAGGGGTGGAGATGGGTGTGGCAGTGTATGGTGTG TGATTTTTATTTTCTTCTTTGGTCATGGGGGCCAAGGAGAAAGGCATGAATCTTCCCTGTCAGGCTCTTACAGCCACAGGCACTGTGTCT >In-frame_ENST00000407756_ENST00000371269_TCGA-4W-AA9T-01A_USP24_chr1_55637229_-_DHCR24_chr1_55337286_length(amino acids)=475AA_start in transcript=0_stop in transcript=1427 MTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGLSESDENCRRFMDRCMPEAFKKLLTSSAVHKWGTEIHE GIYNMLMLLIELVAERIKQDPIPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKSENSDLFYAVPWSCGTL GFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENY LKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTF QNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYH -------------------------------------------------------------- >In-frame_ENST00000407756_ENST00000537443_TCGA-4W-AA9T-01A_USP24_chr1_55637229_-_DHCR24_chr1_55337286_length(transcript)=1794nt_BP=489nt ATGACCACGCTGCTGTGCATGGGCTTCTCAGACCCCGCCACCATCCGCAAGGCCCTGCGCCTGGCCAAGAACGACATTAACGAGGCCGTG GCACTGCTCACCAACGAGCGGCCGGGCCTCGACTACGGCGGCTACGAGCCCATGGACAGCGGCGGTCTTTCCGAGTCTGATGAGAATTGT AGAAGGTTTATGGACAGGTGTATGCCTGAAGCATTTAAAAAGCTCCTGACATCAAGTGCTGTTCACAAGTGGGGTACTGAAATTCATGAA GGAATTTACAACATGTTGATGCTATTAATAGAACTGGTCGCAGAGAGAATAAAACAAGATCCAATTCCCACTGGTCTCCTGGGTGTGCTT ACAATGGCTTTCAATCCTGATAATGAATACCATTTTAAAAACAGAATGAAAGTGTCTCAAAGGAATTGGGCAGAAGTGTTTGGAGAGGGA AATATGTTTGCTGTTTCACCTGTATCGACTTTCCAAAAGTCCGAAAACTCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACGCTG GGTTTCCTGGTGGCCGCTGAGATCCGCATCATCCCTGCCAAGAAGTACGTCAAGCTGCGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATC TGTGCCAAGTTCACCCACGAGTCCCAGCGGCAGGAGAACCACTTCGTGGAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATGACA GGGGTCATGACAGATGAGGCAGAGCCCAGCAAGGACATTATCCCCTTTGGCAACAACCCCATCTTCCGCTACCTCTTTGGCTGGATGGTG CCTCCCAAGATCTCCCTCCTGAAGCTGACCCAGGGTGAGACCCTGCGCAAGCTGTACGAGCAGCACCACGTGGTGCAGGACATGCTGGTG CCCATGAAGTGCCTGCAGCAGGCCCTGCACACCTTCCAAAACGACATCCACGTCTACCCCATCTGGCTGTGTCCGTTCATCCTGCCCAGC CAGCCAGGCCTAGTGCACCCCAAAGGAAATGAGGCAGAGCTCTACATCGACATTGGAGCATATGGGGAGCCGCGTGTGAAACACTTTGAA GCCAGGTCCTGCATGAGGCAGCTGGAGAAGTTTGTCCGCAGCGTGCATGGCTTCCAGATGCTGTATGCCGACTGCTACATGAACCGGGAG GAGTTCTGGGAGATGTTTGATGGCTCCTTGTACCACAAGCTGCGAGAGAAGCTGGGTTGCCAGGACGCCTTCCCCGAGGTGTACGACAAG ATCTGCAAGGCCGCCAGGCACTGAGCTGGAGCCCGCCTGGAGAGACAGACACGTGTGAGTGGTCAGGCATCTTCCCTTCACTCAAGCTTG GCTGCTTTCCTAGATCCACACTTTCAAAGAGAAACCCCTCCAGAACTCCCACCCTGACAGCCCAACACCACCTTCCTCCTGGCTTCCAGG GGGCAGCCCAGTGGAATGGAAAGAATGTGGGATTTGGAGTCAGACAAGCCTGAGTCCAGTTCCCCGTTTAGAACTCATTAGCTGTGTGAC TCTGGGTGAGTCCCTTAACCCCTCTGAGCCCGGGTCTCTTCATTAGTTGAAAGGGATAGTAATACCTACTTGCAGGTTGTTGTCATCTGA GTTGAGCACTGGTCACATTGAAGGTGCTGGGTAAGTGGTAGCTCTTGTTGCTTCCCGTTCAGCGTCACATCTGCAGTGGAGCCTGAAAAG >In-frame_ENST00000407756_ENST00000537443_TCGA-4W-AA9T-01A_USP24_chr1_55637229_-_DHCR24_chr1_55337286_length(amino acids)=427AA_start in transcript=0_stop in transcript=1283 MTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGLSESDENCRRFMDRCMPEAFKKLLTSSAVHKWGTEIHE GIYNMLMLLIELVAERIKQDPIPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKSENSDLFYAVPWSCGTL GFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKDIIPFGNNPIFRYLFGWMV PPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFE -------------------------------------------------------------- >In-frame_ENST00000407756_ENST00000535035_TCGA-4W-AA9T-01A_USP24_chr1_55637229_-_DHCR24_chr1_55337286_length(transcript)=1751nt_BP=489nt ATGACCACGCTGCTGTGCATGGGCTTCTCAGACCCCGCCACCATCCGCAAGGCCCTGCGCCTGGCCAAGAACGACATTAACGAGGCCGTG GCACTGCTCACCAACGAGCGGCCGGGCCTCGACTACGGCGGCTACGAGCCCATGGACAGCGGCGGTCTTTCCGAGTCTGATGAGAATTGT AGAAGGTTTATGGACAGGTGTATGCCTGAAGCATTTAAAAAGCTCCTGACATCAAGTGCTGTTCACAAGTGGGGTACTGAAATTCATGAA GGAATTTACAACATGTTGATGCTATTAATAGAACTGGTCGCAGAGAGAATAAAACAAGATCCAATTCCCACTGGTCTCCTGGGTGTGCTT ACAATGGCTTTCAATCCTGATAATGAATACCATTTTAAAAACAGAATGAAAGTGTCTCAAAGGAATTGGGCAGAAGTGTTTGGAGAGGGA AATATGTTTGCTGTTTCACCTGTATCGACTTTCCAAAAGTCCGAAAACTCAGACCTGTTCTATGCCGTACCCTGGTCCTGTGGGACGCTG GGTTTCCTGGTGGCCGCTGAGATCCGCATCATCCCTGCCAAGAAGTACGTCAAGCTGCGTTTCGAGCCAGTGCGGGGCCTGGAGGCTATC TGTGCCAAGTTCACCCACGAGTCCCAGCGGCAGGAGAACCACTTCGTGGAAGGGCTGCTCTACTCCCTGGATGAGGCTGTCATTATGACA GGGGTCATGACAGATGAGGCAGAGCCCAGCAAGCTGAATAGCATTGGCAATTACTACAAGCCGTGGTTCTTTAAGCATGTGGAGAACTAT CTGAAGACAAACCGAGAGGGCCTGGAGTACATTCCCTTGAGACACTACTACCACCGCCACACGCGCAGCATCTTCTGGGAGCTCCAGGAC ATTATCCCCTTTGGCAACAACCCCATCTTCCGCTACCTCTTTGGCTGGATGGTGCCTCCCAAGATCTCCCTCCTGAAGCTGACCCAGGGT GAGACCCTGCGCAAGCTGTACGAGCAGCACCACGTGGTGCAGGACATGCTGGTGCCCATGAAGTGCCTGCAGCAGGCCCTGCACACCTTC CAAAACGACATCCACGTCTACCCCATCTGGCTGTGTCCGTTCATCCTGCCCAGCCAGCCAGGCCTAGTGCACCCCAAAGGAAATGAGGCA GAGCTCTACATCGACATTGGAGCATATGGGGAGCCGCGTGTGAAACACTTTGAAGCCAGGTCCTGCATGAGGCAGCTGGAGAAGTTTGTC CGCAGCGTGCATGGCTTCCAGATGCTGTATGCCGACTGCTACATGAACCGGGAGGAGTTCTGGGAGATGTTTGATGGCTCCTTGTACCAC AAGCTGCGAGAGAAGCTGGGTTGCCAGGACGCCTTCCCCGAGGTGTACGACAAGATCTGCAAGGCCGCCAGGCACTGAGCTGGAGCCCGC CTGGAGAGACAGACACGTGTGAGTGGTCAGGCATCTTCCCTTCACTCAAGCTTGGCTGCTTTCCTAGATCCACACTTTCAAAGAGAAACC CCTCCAGAACTCCCACCCTGACAGCCCAACACCACCTTCCTCCTGGCTTCCAGGGGGCAGCCCAGTGGAATGGAAAGAATGTGGGATTTG GAGTCAGACAAGCCTGAGTCCAGTTCCCCGTTTAGAACTCATTAGCTGTGTGACTCTGGGTGAGTCCCTTAACCCCTCTGAGCCCGGGTC >In-frame_ENST00000407756_ENST00000535035_TCGA-4W-AA9T-01A_USP24_chr1_55637229_-_DHCR24_chr1_55337286_length(amino acids)=475AA_start in transcript=0_stop in transcript=1427 MTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGGLSESDENCRRFMDRCMPEAFKKLLTSSAVHKWGTEIHE GIYNMLMLLIELVAERIKQDPIPTGLLGVLTMAFNPDNEYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKSENSDLFYAVPWSCGTL GFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENY LKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTF QNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYH -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for USP24-DHCR24 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for USP24-DHCR24 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for USP24-DHCR24 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DHCR24 | C1865596 | Desmosterolosis | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Tgene | DHCR24 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
| Tgene | DHCR24 | C0011265 | Presenile dementia | 1 | CTD_human |
| Tgene | DHCR24 | C0034362 | Q Fever | 1 | CTD_human |
| Tgene | DHCR24 | C0276496 | Familial Alzheimer Disease (FAD) | 1 | CTD_human |
| Tgene | DHCR24 | C0494463 | Alzheimer Disease, Late Onset | 1 | CTD_human |
| Tgene | DHCR24 | C0519066 | Acute Q fever | 1 | CTD_human |
| Tgene | DHCR24 | C0546126 | Acute Confusional Senile Dementia | 1 | CTD_human |
| Tgene | DHCR24 | C0750900 | Alzheimer's Disease, Focal Onset | 1 | CTD_human |
| Tgene | DHCR24 | C0750901 | Alzheimer Disease, Early Onset | 1 | CTD_human |
| Tgene | DHCR24 | C1443892 | Chronic Q Fever | 1 | CTD_human |
| Tgene | DHCR24 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
| Tgene | DHCR24 | C2973787 | Coxiella burnetii Infection | 1 | CTD_human |
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