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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP31-RHD (FusionGDB2 ID:96682)

Fusion Gene Summary for USP31-RHD

check button Fusion gene summary
Fusion gene informationFusion gene name: USP31-RHD
Fusion gene ID: 96682
HgeneTgene
Gene symbol

USP31

RHD

Gene ID

84196

6007

Gene nameubiquitin specific peptidase 48Rh blood group D antigen
SynonymsRAP1GA1|USP31CD240D|DIIIc|RH|RH30|RHCED|RHDVA(TT)|RHDel|RHPII|RHXIII|Rh4|RhDCw|RhII|RhK562-II|RhPI
Cytomap

1p36.12

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 48deubiquitinating enzyme 48ubiquitin specific protease 31ubiquitin thioesterase 48ubiquitin thiolesterase 48ubiquitin-specific-processing protease 48blood group Rh(D) polypeptideD antigen (DCS)RH polypeptide 2Rh blood group C antigenRh blood group CE antigenRh blood group CcEe antigenRh blood group antigen EvansRh blood group, D anitgenRhD antigenRhD blood group antigenRhD polypeptideRhesus
Modification date2020031320200323
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000219689, ENST00000567975, 
ENST00000328664, ENST00000454452, 
ENST00000423253, ENST00000423810, 
ENST00000568195, ENST00000417538, 
ENST00000342055, ENST00000357542, 
Fusion gene scores* DoF score15 X 9 X 6=8104 X 3 X 4=48
# samples 154
** MAII scorelog2(15/810*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP31 [Title/Abstract] AND RHD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP31(23113640)-RHD(25611064), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across USP31 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RHD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-A9RL-01AUSP31chr16

23113640

-RHDchr1

25611064

+
ChimerDB4BLCATCGA-ZF-A9RL-01AUSP31chr16

23113640

-RHDchr1

25611064

+
ChimerDB4BLCATCGA-ZF-A9RL-01AUSP31chr16

23113640

-RHDchr1

25611064

+


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Fusion Gene ORF analysis for USP31-RHD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000219689ENST00000328664USP31chr16

23113640

-RHDchr1

25611064

+
In-frameENST00000219689ENST00000454452USP31chr16

23113640

-RHDchr1

25611064

+
5CDS-3UTRENST00000219689ENST00000423253USP31chr16

23113640

-RHDchr1

25611064

+
5CDS-3UTRENST00000219689ENST00000423810USP31chr16

23113640

-RHDchr1

25611064

+
5CDS-3UTRENST00000219689ENST00000568195USP31chr16

23113640

-RHDchr1

25611064

+
5CDS-3UTRENST00000219689ENST00000417538USP31chr16

23113640

-RHDchr1

25611064

+
5CDS-3UTRENST00000219689ENST00000342055USP31chr16

23113640

-RHDchr1

25611064

+
5CDS-3UTRENST00000219689ENST00000357542USP31chr16

23113640

-RHDchr1

25611064

+
intron-3CDSENST00000567975ENST00000328664USP31chr16

23113640

-RHDchr1

25611064

+
intron-3CDSENST00000567975ENST00000454452USP31chr16

23113640

-RHDchr1

25611064

+
intron-3UTRENST00000567975ENST00000423253USP31chr16

23113640

-RHDchr1

25611064

+
intron-3UTRENST00000567975ENST00000423810USP31chr16

23113640

-RHDchr1

25611064

+
intron-3UTRENST00000567975ENST00000568195USP31chr16

23113640

-RHDchr1

25611064

+
intron-3UTRENST00000567975ENST00000417538USP31chr16

23113640

-RHDchr1

25611064

+
intron-3UTRENST00000567975ENST00000342055USP31chr16

23113640

-RHDchr1

25611064

+
intron-3UTRENST00000567975ENST00000357542USP31chr16

23113640

-RHDchr1

25611064

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000219689USP31chr1623113640-ENST00000328664RHDchr125611064+3861123402339779
ENST00000219689USP31chr1623113640-ENST00000454452RHDchr125611064+2339123402051683

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000219689ENST00000328664USP31chr1623113640-RHDchr125611064+0.0047890160.99521106
ENST00000219689ENST00000454452USP31chr1623113640-RHDchr125611064+0.0181839540.98181605

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Fusion Genomic Features for USP31-RHD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USP31chr1623113639-RHDchr125611063+3.85E-081
USP31chr1623113639-RHDchr125611063+3.85E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP31-RHD


check button Go to

FGviewer for the breakpoints of chr16:23113640-chr1:25611064

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP31chr16:23113640chr1:25611064ENST00000219689-61695_125411.33333333333331353.0Compositional biasNote=Pro-rich
TgeneRHDchr16:23113640chr1:25611064ENST00000328664010107_12749.333333333333336418.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST00000328664010130_15049.333333333333336418.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST00000328664010167_18749.333333333333336418.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST00000328664010203_22349.333333333333336418.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST00000328664010238_25849.333333333333336418.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST00000328664010287_30749.333333333333336418.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST00000328664010334_35449.333333333333336418.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST00000328664010358_37849.333333333333336418.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000032866401077_9749.333333333333336418.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000034205509107_12749.333333333333336494.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000034205509130_15049.333333333333336494.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000034205509167_18749.333333333333336494.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000034205509203_22349.333333333333336494.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000034205509238_25849.333333333333336494.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000034205509287_30749.333333333333336494.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000034205509334_35449.333333333333336494.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000034205509358_37849.333333333333336494.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST000003420550977_9749.333333333333336494.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000035754208107_12749.333333333333336397.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000035754208130_15049.333333333333336397.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000035754208167_18749.333333333333336397.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000035754208203_22349.333333333333336397.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000035754208238_25849.333333333333336397.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000035754208287_30749.333333333333336397.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000035754208334_35449.333333333333336397.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000035754208358_37849.333333333333336397.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST000003575420877_9749.333333333333336397.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000041753808107_12749.333333333333336379.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000041753808130_15049.333333333333336379.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000041753808167_18749.333333333333336379.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000041753808203_22349.333333333333336379.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000041753808238_25849.333333333333336379.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000041753808287_30749.333333333333336379.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000041753808334_35449.333333333333336379.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000041753808358_37849.333333333333336379.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST000004175380877_9749.333333333333336379.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000045445207107_12749.333333333333336322.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000045445207130_15049.333333333333336322.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000045445207167_18749.333333333333336322.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000045445207203_22349.333333333333336322.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000045445207238_25849.333333333333336322.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000045445207287_30749.333333333333336322.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000045445207334_35449.333333333333336322.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000045445207358_37849.333333333333336322.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST000004544520777_9749.333333333333336322.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP31chr16:23113640chr1:25611064ENST00000219689-616770_1221411.33333333333331353.0Compositional biasNote=Ser-rich
HgeneUSP31chr16:23113640chr1:25611064ENST00000219689-616128_765411.33333333333331353.0DomainNote=USP
TgeneRHDchr16:23113640chr1:25611064ENST0000032866401012_3249.333333333333336418.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST0000032866401044_6449.333333333333336418.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST000003420550912_3249.333333333333336494.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST000003420550944_6449.333333333333336494.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST000003575420812_3249.333333333333336397.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST000003575420844_6449.333333333333336397.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST000004175380812_3249.333333333333336379.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST000004175380844_6449.333333333333336379.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST000004544520712_3249.333333333333336322.0TransmembraneHelical
TgeneRHDchr16:23113640chr1:25611064ENST000004544520744_6449.333333333333336322.0TransmembraneHelical


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Fusion Gene Sequence for USP31-RHD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000219689_ENST00000328664_TCGA-ZF-A9RL-01A_USP31_chr16_23113640_-_RHD_chr1_25611064_length(transcript)=3861nt_BP=1234nt
ATGTCCAAGGTAACGGCGCCTGGGTCCGGGCCGCCGGCGGCGGCGAGCGGGAAGGAGAAGCGCTCCTTCAGCAAGCGGCTGTTTCGGAGC
GGCCGCGCTGGCGGCGGCGGCGCGGGGGGCCCCGGGGCGTCCGGGCCGGCCGCGCCTTCCTCGCCCTCCTCGCCCTCCTCTGCACGCTCG
GTGGGCAGCTTCATGAGCCGCGTTCTCAAGACGCTGTCCACGCTCTCGCACCTTAGCTCTGAGGGCGCCGCCCCAGACCGCGGCGGCCTC
CGCAGCTGCTTCCCGCCCGGGCCGGCCGCCGCGCCCACGCCGCCGCCGTGCCCGCCGCCGCCCGCCTCTCCCGCGCCGCCCGCTTGCGCC
GCCGAGCCGGTGCCCGGCGTGGCGGGGCTCCGCAACCACGGCAACACGTGCTTCATGAACGCCACGCTGCAGTGCCTCAGCAACACCGAG
CTCTTCGCCGAGTACCTGGCGCTGGGCCAGTACCGGGCGGGGCGGCCCGAGCCCTCGCCTGACCCGGAGCAGCCTGCGGGCCGCGGCGCG
CAGGGCCAGGGCGAGGTCACTGAGCAGCTGGCGCACCTGGTGCGGGCCCTCTGGACCCTGGAGTACACCCCGCAGCACAGCCGCGACTTC
AAGACTATTGTGTCAAAGAATGCACTGCAGTACCGGGGAAATTCCCAACATGATGCCCAGGAGTTTCTGCTGTGGCTTTTGGACCGAGTT
CATGAAGACCTCAACCATTCAGTGAAGCAGAGTGGCCAGCCTCCTCTGAAGCCACCATCAGAGACTGATATGATGCCTGAGGGACCATCT
TTCCCTGTCTGTAGCACTTTTGTACAAGAACTCTTTCAAGCGCAATACAGATCTTCTTTGACGTGTCCTCATTGTCAGAAACAGAGCAAC
ACTTTTGATCCTTTCCTTTGCATTTCTTTGCCAATTCCTCTGCCCCACACAAGGCCTCTCTATGTCACTGTAGTGTATCAAGGCAAATGT
TCTCACTGCATGAGGATTGGTGTGGCCGTACCTCTGTCTGGGACTGTCGCCAGACTTCGGGAAGCAGTGTCTATGGAAACAAAGATCCCC
ACTGATCAGATTGTGTTAACAGAAATGTACTATGATGGGTTCCATCGTTCCTTTTGTGATACAGACGACCTGGAAACAGTCCATGAAAGC
GACTGCATTTTTGCCTTTGAGACTCCCGAAATATTTAGGCCTGAAGGAATTCTCAGTCAAAGAGTTGGCCAAGATCTGACCGTGATGGCG
GCCATTGGCTTGGGCTTCCTCACCTCGAGTTTCCGGAGACACAGCTGGAGCAGTGTGGCCTTCAACCTCTTCATGCTGGCGCTTGGTGTG
CAGTGGGCAATCCTGCTGGACGGCTTCCTGAGCCAGTTCCCTTCTGGGAAGGTGGTCATCACACTGTTCAGTATTCGGCTGGCCACCATG
AGTGCTTTGTCGGTGCTGATCTCAGTGGATGCTGTCTTGGGGAAGGTCAACTTGGCGCAGTTGGTGGTGATGGTGCTGGTGGAGGTGACA
GCTTTAGGCAACCTGAGGATGGTCATCAGTAATATCTTCAACACAGACTACCACATGAACATGATGCACATCTACGTGTTCGCAGCCTAT
TTTGGGCTGTCTGTGGCCTGGTGCCTGCCAAAGCCTCTACCCGAGGGAACGGAGGATAAAGATCAGACAGCAACGATACCCAGTTTGTCT
GCCATGCTGGGCGCCCTCTTCTTGTGGATGTTCTGGCCAAGTTTCAACTCTGCTCTGCTGAGAAGTCCAATCGAAAGGAAGAATGCCGTG
TTCAACACCTACTATGCTGTAGCAGTCAGCGTGGTGACAGCCATCTCAGGGTCATCCTTGGCTCACCCCCAAGGGAAGATCAGCAAGACT
TATGTGCACAGTGCGGTGTTGGCAGGAGGCGTGGCTGTGGGTACCTCGTGTCACCTGATCCCTTCTCCGTGGCTTGCCATGGTGCTGGGT
CTTGTGGCTGGGCTGATCTCCGTCGGGGGAGCCAAGTACCTGCCGGGGTGTTGTAACCGAGTGCTGGGGATTCCCCACAGCTCCATCATG
GGCTACAACTTCAGCTTGCTGGGTCTGCTTGGAGAGATCATCTACATTGTGCTGCTGGTGCTTGATACCGTCGGAGCCGGCAATGGCATG
ATTGGCTTCCAGGTCCTCCTCAGCATTGGGGAACTCAGCTTGGCCATCGTGATAGCTCTCATGTCTGGTCTCCTGACAGGTTTGCTCCTA
AATCTTAAAATATGGAAAGCACCTCATGAGGCTAAATATTTTGATGACCAAGTTTTCTGGAAGTTTCCTCATTTGGCTGTTGGATTTTAA
GCAAAAGCATCCAAGAAAAACAAGGCCTGTTCAAAAACAAGACAACTTCCTCTCACTGTTGCCTGCATTTGTACGTGAGAAACGCTCATG
ACAGCAAAGTCTCCAATGTTCGCGCAGGCACTGGAGTCAGAGAAAATGGAGTTGAATCCTTTCTCTGCCACTCTTTGAGGAGAATCTCAC
CATTTATTATGCACTGTAGAATACAACAATAAAATACAGCCATGTACCACATAACAACATCTTGGTAAACAACAGACTGCATATATGATG
GTGGTCATCCAGTAAGCTAAGGTTAATTTATTATTATTCCTTGTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGTAGTCTTACTCTGTCA
CCCAGGCTAGAGTGCAATGGCACCATCTTGGCTCACTGCAACCTCTACCTCCTGGGTTCAAGCAAATCTCCTGCCTCAGCCTCCAAAGTA
GCTGGGATTACAGGCACCCACCACATCTGGCTAATTTTTTGTATTTTTAGTAAAGATGGGGTTTCACCATGTTGGCCAGGCTGATCTCAA
ACTCCTGACCTCAAGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGAACCACAGGCCTGAGCCACTGTGCCCAGCCTTGTTTGCTTTT
TTAACAGATAACAGTGTGCTCATAGAAACTGCTTTGACATGACTGCAATCATGTGCTTCATAGAAACTTAATTAGATTATACCACTAGAG
TCTTCAGATTTTTATACTTTTTTTTTTTGAAACGGAGTCTCACTCTGTCACCAGGCTGGAGTGCAGTGCCGCAATCTCGGCTCACTGCAA
CCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAAGTGCGCACTACCACACCCAGCTAATTTT
TGCATTTTTACTTGACAGGGTTTCACCATGTTGGCTAGGATAGTTTCACCAGGATCTCTTGGCCTCATGATCAGCCTGCCTCGGCCTCCC
AAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCAGCCTATACTTCCCTTTTTGAATACCATTTGGTGTTTTGAAGAATTAACAGCTT
TGTGAACGTGGCAGTGCTTGTGATTCAGGCTTCCATTGAGACCAAGGGGAGAACCTGGTTGCAGGACAAACAGACGGACAGCGTGTGGCA
GTGTTTAAATGCTCTTCTGAAGGCTGATACGACAGCTCTCTGTGCACTGATTGCATATGCATCCCAAGATTATATTATTGTTTTCTACTG
CTATGTGTCACACTTTGCCAAACAGGATGTGGAAAATGAATAAGCGGTTTTCTTAGGCACTTCTTAACAGACAATTGGTCAAAATGAACT
CCATTGCTTAAGAAACACATAAACACCATTTAGTCACTGAACATAGCTATATGTATGGTTGTTACTATGGGAAATCTTGTTTTGCCAATT

>In-frame_ENST00000219689_ENST00000328664_TCGA-ZF-A9RL-01A_USP31_chr16_23113640_-_RHD_chr1_25611064_length(amino acids)=779AA_start in transcript=0_stop in transcript=2339
MSKVTAPGSGPPAAASGKEKRSFSKRLFRSGRAGGGGAGGPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGL
RSCFPPGPAAAPTPPPCPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGA
QGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPS
FPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIP
TDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETPEIFRPEGILSQRVGQDLTVMAAIGLGFLTSSFRRHSWSSVAFNLFMLALGV
QWAILLDGFLSQFPSGKVVITLFSIRLATMSALSVLISVDAVLGKVNLAQLVVMVLVEVTALGNLRMVISNIFNTDYHMNMMHIYVFAAY
FGLSVAWCLPKPLPEGTEDKDQTATIPSLSAMLGALFLWMFWPSFNSALLRSPIERKNAVFNTYYAVAVSVVTAISGSSLAHPQGKISKT
YVHSAVLAGGVAVGTSCHLIPSPWLAMVLGLVAGLISVGGAKYLPGCCNRVLGIPHSSIMGYNFSLLGLLGEIIYIVLLVLDTVGAGNGM

--------------------------------------------------------------
>In-frame_ENST00000219689_ENST00000454452_TCGA-ZF-A9RL-01A_USP31_chr16_23113640_-_RHD_chr1_25611064_length(transcript)=2339nt_BP=1234nt
ATGTCCAAGGTAACGGCGCCTGGGTCCGGGCCGCCGGCGGCGGCGAGCGGGAAGGAGAAGCGCTCCTTCAGCAAGCGGCTGTTTCGGAGC
GGCCGCGCTGGCGGCGGCGGCGCGGGGGGCCCCGGGGCGTCCGGGCCGGCCGCGCCTTCCTCGCCCTCCTCGCCCTCCTCTGCACGCTCG
GTGGGCAGCTTCATGAGCCGCGTTCTCAAGACGCTGTCCACGCTCTCGCACCTTAGCTCTGAGGGCGCCGCCCCAGACCGCGGCGGCCTC
CGCAGCTGCTTCCCGCCCGGGCCGGCCGCCGCGCCCACGCCGCCGCCGTGCCCGCCGCCGCCCGCCTCTCCCGCGCCGCCCGCTTGCGCC
GCCGAGCCGGTGCCCGGCGTGGCGGGGCTCCGCAACCACGGCAACACGTGCTTCATGAACGCCACGCTGCAGTGCCTCAGCAACACCGAG
CTCTTCGCCGAGTACCTGGCGCTGGGCCAGTACCGGGCGGGGCGGCCCGAGCCCTCGCCTGACCCGGAGCAGCCTGCGGGCCGCGGCGCG
CAGGGCCAGGGCGAGGTCACTGAGCAGCTGGCGCACCTGGTGCGGGCCCTCTGGACCCTGGAGTACACCCCGCAGCACAGCCGCGACTTC
AAGACTATTGTGTCAAAGAATGCACTGCAGTACCGGGGAAATTCCCAACATGATGCCCAGGAGTTTCTGCTGTGGCTTTTGGACCGAGTT
CATGAAGACCTCAACCATTCAGTGAAGCAGAGTGGCCAGCCTCCTCTGAAGCCACCATCAGAGACTGATATGATGCCTGAGGGACCATCT
TTCCCTGTCTGTAGCACTTTTGTACAAGAACTCTTTCAAGCGCAATACAGATCTTCTTTGACGTGTCCTCATTGTCAGAAACAGAGCAAC
ACTTTTGATCCTTTCCTTTGCATTTCTTTGCCAATTCCTCTGCCCCACACAAGGCCTCTCTATGTCACTGTAGTGTATCAAGGCAAATGT
TCTCACTGCATGAGGATTGGTGTGGCCGTACCTCTGTCTGGGACTGTCGCCAGACTTCGGGAAGCAGTGTCTATGGAAACAAAGATCCCC
ACTGATCAGATTGTGTTAACAGAAATGTACTATGATGGGTTCCATCGTTCCTTTTGTGATACAGACGACCTGGAAACAGTCCATGAAAGC
GACTGCATTTTTGCCTTTGAGACTCCCGAAATATTTAGGCCTGAAGGAATTCTCAGTCAAAGAGTTGGCCAAGATCTGACCGTGATGGCG
GCCATTGGCTTGGGCTTCCTCACCTCGAGTTTCCGGAGACACAGCTGGAGCAGTGTGGCCTTCAACCTCTTCATGCTGGCGCTTGGTGTG
CAGTGGGCAATCCTGCTGGACGGCTTCCTGAGCCAGTTCCCTTCTGGGAAGGTGGTCATCACACTGTTCAGTATTCGGCTGGCCACCATG
AGTGCTTTGTCGGTGCTGATCTCAGTGGATGCTGTCTTGGGGAAGGTCAACTTGGCGCAGTTGGTGGTGATGGTGCTGGTGGAGGTGACA
GCTTTAGGCAACCTGAGGATGGTCATCAGTAATATCTTCAACACAGACTACCACATGAACATGATGCACATCTACGTGTTCGCAGCCTAT
TTTGGGCTGTCTGTGGCCTGGTGCCTGCCAAAGCCTCTACCCGAGGGAACGGAGGATAAAGATCAGACAGCAACGATACCCAGTTTGTCT
GCCATGCTGGGCGCCCTCTTCTTGTGGATGTTCTGGCCAAGTTTCAACTCTGCTCTGCTGAGAAGTCCAATCGAAAGGAAGAATGCCGTG
TTCAACACCTACTATGCTGTAGCAGTCAGCGTGGTGACAGCCATCTCAGGGTCATCCTTGGCTCACCCCCAAGGGAAGATCAGCAAGACT
TATGTGCACAGTGCGGTGTTGGCAGGAGGCGTGGCTGTGGGTACCTCGTGTCACCTGATCCCTTCTCCGTGGCTTGCCATGGTGCTGGGT
CTTGTGGCTGGGCTGATCTCCGTCGGGGGAGCCAAGTACCTGCCGTTTCCTCATTTGGCTGTTGGATTTTAAGCAAAAGCATCCAAGAAA
AACAAGGCCTGTTCAAAAACAAGACAACTTCCTCTCACTGTTGCCTGCATTTGTACGTGAGAAACGCTCATGACAGCAAAGTCTCCAATG
TTCGCGCAGGCACTGGAGTCAGAGAAAATGGAGTTGAATCCTTTCTCTGCCACTCTTTGAGGAGAATCTCACCATTTATTATGCACTGTA

>In-frame_ENST00000219689_ENST00000454452_TCGA-ZF-A9RL-01A_USP31_chr16_23113640_-_RHD_chr1_25611064_length(amino acids)=683AA_start in transcript=0_stop in transcript=2051
MSKVTAPGSGPPAAASGKEKRSFSKRLFRSGRAGGGGAGGPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGL
RSCFPPGPAAAPTPPPCPPPPASPAPPACAAEPVPGVAGLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGA
QGQGEVTEQLAHLVRALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMMPEGPS
FPVCSTFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPLPHTRPLYVTVVYQGKCSHCMRIGVAVPLSGTVARLREAVSMETKIP
TDQIVLTEMYYDGFHRSFCDTDDLETVHESDCIFAFETPEIFRPEGILSQRVGQDLTVMAAIGLGFLTSSFRRHSWSSVAFNLFMLALGV
QWAILLDGFLSQFPSGKVVITLFSIRLATMSALSVLISVDAVLGKVNLAQLVVMVLVEVTALGNLRMVISNIFNTDYHMNMMHIYVFAAY
FGLSVAWCLPKPLPEGTEDKDQTATIPSLSAMLGALFLWMFWPSFNSALLRSPIERKNAVFNTYYAVAVSVVTAISGSSLAHPQGKISKT

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Fusion Gene PPI Analysis for USP31-RHD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP31-RHD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP31-RHD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRHDC0036341Schizophrenia3PSYGENET
TgeneRHDC0002881Anemia, Hemolytic, Congenital1CTD_human
TgeneRHDC0272052Rh Deficiency Syndrome1ORPHANET
TgeneRHDC1849387Rh-Null, Regulator Type1ORPHANET