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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP32-CDK12 (FusionGDB2 ID:96691)

Fusion Gene Summary for USP32-CDK12

check button Fusion gene summary
Fusion gene informationFusion gene name: USP32-CDK12
Fusion gene ID: 96691
HgeneTgene
Gene symbol

USP32

CDK12

Gene ID

84669

51755

Gene nameubiquitin specific peptidase 32cyclin dependent kinase 12
SynonymsNY-REN-60|USP10CRK7|CRKR|CRKRS
Cytomap

17q23.1-q23.2

17q12

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32cyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12
Modification date2020031320200313
UniProtAcc.

Q9NYV4

Ensembl transtripts involved in fusion geneENST00000300896, ENST00000592339, 
ENST00000393003, ENST00000586881, 
ENST00000430627, ENST00000447079, 
ENST00000559545, 
Fusion gene scores* DoF score36 X 25 X 11=990036 X 30 X 14=15120
# samples 4255
** MAII scorelog2(42/9900*10)=-4.55896729218821
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(55/15120*10)=-4.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP32 [Title/Abstract] AND CDK12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP32(58378959)-CDK12(37646809), # samples:2
Anticipated loss of major functional domain due to fusion event.USP32-CDK12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
USP32-CDK12 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
USP32-CDK12 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
USP32-CDK12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
USP32-CDK12 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDK12

GO:0046777

protein autophosphorylation

11683387


check buttonFusion gene breakpoints across USP32 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CDK12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-V5-A7RE-11AUSP32chr17

58378959

-CDK12chr17

37646809

+
ChimerDB4Non-CancerTCGA-V5-A7RE-11AUSP32chr17

58378959

-CDK12chr17

37646809

+


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Fusion Gene ORF analysis for USP32-CDK12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000300896ENST00000430627USP32chr17

58378959

-CDK12chr17

37646809

+
Frame-shiftENST00000300896ENST00000447079USP32chr17

58378959

-CDK12chr17

37646809

+
5CDS-intronENST00000300896ENST00000559545USP32chr17

58378959

-CDK12chr17

37646809

+
intron-3CDSENST00000592339ENST00000430627USP32chr17

58378959

-CDK12chr17

37646809

+
intron-3CDSENST00000592339ENST00000447079USP32chr17

58378959

-CDK12chr17

37646809

+
intron-intronENST00000592339ENST00000559545USP32chr17

58378959

-CDK12chr17

37646809

+
Frame-shiftENST00000393003ENST00000430627USP32chr17

58378959

-CDK12chr17

37646809

+
Frame-shiftENST00000393003ENST00000447079USP32chr17

58378959

-CDK12chr17

37646809

+
5CDS-intronENST00000393003ENST00000559545USP32chr17

58378959

-CDK12chr17

37646809

+
In-frameENST00000586881ENST00000430627USP32chr17

58378959

-CDK12chr17

37646809

+
In-frameENST00000586881ENST00000447079USP32chr17

58378959

-CDK12chr17

37646809

+
5CDS-intronENST00000586881ENST00000559545USP32chr17

58378959

-CDK12chr17

37646809

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000586881USP32chr1758378959-ENST00000430627CDK12chr1737646809+40053294352843802
ENST00000586881USP32chr1758378959-ENST00000447079CDK12chr1737646809+67013294352870811

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000586881ENST00000430627USP32chr1758378959-CDK12chr1737646809+0.0019651380.9980349
ENST00000586881ENST00000447079USP32chr1758378959-CDK12chr1737646809+0.0003450840.9996549

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Fusion Genomic Features for USP32-CDK12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USP32chr1758378959-CDK12chr1737646809+4.18E-081
USP32chr1758378959-CDK12chr1737646809+4.18E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP32-CDK12


check button Go to

FGviewer for the breakpoints of chr17:58378959-chr17:37646809

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDK12

Q9NYV4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDK12chr17:58378959chr17:37646809ENST000004306271141266_1280643.66666666666661482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:58378959chr17:37646809ENST000004470791141266_1280643.66666666666661491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:58378959chr17:37646809ENST00000430627114727_1020643.66666666666661482.0DomainProtein kinase
TgeneCDK12chr17:58378959chr17:37646809ENST00000447079114727_1020643.66666666666661491.0DomainProtein kinase
TgeneCDK12chr17:58378959chr17:37646809ENST00000430627114733_741643.66666666666661482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:58378959chr17:37646809ENST00000430627114814_819643.66666666666661482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:58378959chr17:37646809ENST00000447079114733_741643.66666666666661491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:58378959chr17:37646809ENST00000447079114814_819643.66666666666661491.0Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP32chr17:58378959chr17:37646809ENST00000300896-334241_25297.333333333333331605.0Calcium binding1
HgeneUSP32chr17:58378959chr17:37646809ENST00000300896-334277_28897.333333333333331605.0Calcium binding2
HgeneUSP32chr17:58378959chr17:37646809ENST00000300896-334228_26397.333333333333331605.0DomainEF-hand 2
HgeneUSP32chr17:58378959chr17:37646809ENST00000300896-334264_29997.333333333333331605.0DomainEF-hand 3
HgeneUSP32chr17:58378959chr17:37646809ENST00000300896-334369_58597.333333333333331605.0DomainDUSP
HgeneUSP32chr17:58378959chr17:37646809ENST00000300896-334734_156797.333333333333331605.0DomainNote=USP
HgeneUSP32chr17:58378959chr17:37646809ENST00000300896-33491_12697.333333333333331605.0DomainEF-hand 1
TgeneCDK12chr17:58378959chr17:37646809ENST00000430627114407_413643.66666666666661482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:58378959chr17:37646809ENST00000430627114535_540643.66666666666661482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:58378959chr17:37646809ENST00000447079114407_413643.66666666666661491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:58378959chr17:37646809ENST00000447079114535_540643.66666666666661491.0Compositional biasNote=Poly-Pro


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Fusion Gene Sequence for USP32-CDK12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000586881_ENST00000430627_TCGA-V5-A7RE-11A_USP32_chr17_58378959_-_CDK12_chr17_37646809_length(transcript)=4005nt_BP=329nt
AGCAGATGCTGGTGCCATGCTTATACAGGCTGCAGAACCGTGAGCCAAAAAAACCTCTTTTCTTTATAAAAATTACCCAGCCTCAGGTTA
AAATTCTGACTCTGCTGCTTCATTGATGTATGACTTTGGACAAGTTACTTAATCTCTTTGGGCTCTGGTTTCCCCCAGCCCTAAAATGAG
GATACCAGTATTCCTTGTGGAGTCATCTAAAGGCTTAATACTGGTGATTTACTGTTCTTTTGGTGGAACATCCAAAGGGCTGCACTTCAA
TAATTTAATAGTTGGACTTGTCCTCCTTACAAGAGGCAAAGATGAAGAGAAAGCAAAATTCCAAAAGAAACTCTTCCTTCAAAACCTGTG
AAGAAAGAGAAGGAACAGAGGACACGTCACTTACTCACAGACCTTCCTCTCCCTCCAGAGCTCCCTGGTGGAGATCTGTCTCCCCCAGAC
TCTCCAGAACCAAAGGCAATCACACCACCTCAGCAACCATATAAAAAGAGACCAAAAATTTGTTGTCCTCGTTATGGAGAAAGAAGACAA
ACAGAAAGCGACTGGGGGAAACGCTGTGTGGACAAGTTTGACATTATTGGGATTATTGGAGAAGGAACCTATGGCCAAGTATATAAAGCC
AAGGACAAAGACACAGGAGAACTAGTGGCTCTGAAGAAGGTGAGACTAGACAATGAGAAAGAGGGCTTCCCAATCACAGCCATTCGTGAA
ATCAAAATCCTTCGTCAGTTAATCCACCGAAGTGTTGTTAACATGAAGGAAATTGTCACAGATAAACAAGATGCACTGGATTTCAAGAAG
GACAAAGGTGCCTTTTACCTTGTATTTGAGTATATGGACCATGACTTAATGGGACTGCTAGAATCTGGTTTGGTGCACTTTTCTGAGGAC
CATATCAAGTCGTTCATGAAACAGCTAATGGAAGGATTGGAATACTGTCACAAAAAGAATTTCCTGCATCGGGATATTAAGTGTTCTAAC
ATTTTGCTGAATAACAGTGGGCAAATCAAACTAGCAGATTTTGGACTTGCTCGGCTCTATAACTCTGAAGAGAGTCGCCCTTACACAAAC
AAAGTCATTACTTTGTGGTACCGACCTCCAGAACTACTGCTAGGAGAGGAACGTTACACACCAGCCATAGATGTTTGGAGCTGTGGATGT
ATTCTTGGGGAACTATTCACAAAGAAGCCTATTTTTCAAGCCAATCTGGAACTGGCTCAGCTAGAACTGATCAGCCGACTTTGTGGTAGC
CCTTGTCCAGCTGTGTGGCCTGATGTTATCAAACTGCCCTACTTCAACACCATGAAACCGAAGAAGCAATATCGAAGGCGTCTACGAGAA
GAATTCTCTTTCATTCCTTCTGCAGCACTTGATTTATTGGACCACATGCTGACACTAGATCCTAGTAAGCGGTGCACAGCTGAACAGACC
CTACAGAGCGACTTCCTTAAAGATGTCGAACTCAGCAAAATGGCTCCTCCAGACCTCCCCCACTGGCAGGATTGCCATGAGTTGTGGAGT
AAGAAACGGCGACGTCAGCGACAAAGTGGTGTTGTAGTCGAAGAGCCACCTCCATCCAAAACTTCTCGAAAAGAAACTACCTCAGGGACA
AGTACTGAGCCTGTGAAGAACAGCAGCCCAGCACCACCTCAGCCTGCTCCTGGCAAGGTGGAGTCTGGGGCTGGGGATGCAATAGGCCTT
GCTGACATCACACAACAGCTGAATCAAAGTGAATTGGCAGTGTTATTAAACCTGCTGCAGAGCCAAACCGACCTGAGCATCCCTCAAATG
GCACAGCTGCTTAACATCCACTCCAACCCAGAGATGCAGCAGCAGCTGGAAGCCCTGAACCAATCCATCAGTGCCCTGACGGAAGCTACT
TCCCAGCAGCAGGACTCAGAGACCATGGCCCCAGAGGAGTCTTTGAAGGAAGCACCCTCTGCCCCAGTGATCCTGCCTTCAGCAGAACAG
ACGACCCTTGAAGCTTCAAGCACACCAGCTGACATGCAGAATATATTGGCAGTTCTCTTGAGTCAGCTGATGAAAACCCAAGAGCCAGCA
GGCAGTCTGGAGGAAAACAACAGTGACAAGAACAGTGGGCCACAGGGGCCCCGAAGAACTCCCACAATGCCACAGGAGGAGGCAGCAGAG
AAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGCGATCTTTCCAGCGCCCCCCAGGAGTTG
AACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGCCACCTGCCACATGAGCACCAGGCCTTG
AGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCTGAAACAGGGTTCAGTGCCATTGACACT
GATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGGACCTTCTCAGGCTCTCTGAGCCACCTT
GGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGTTTTGCCAGGGTCCCCTTAGCGTTACAC
CCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAGACCAAATTGCAAAACTATGGGGAGCTG
GGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAGTCTTCTGCTTATGGAAAACTCTATCGG
GGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGACTTCAGTGTCCTGAAAGATTCCTTTCCT
ATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCATCTGCATTTGGCTACTGCAAAGCTGTC
CGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAGTTCCCCCTGGATGGGCTATAGCCAGAA
CATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGAAAAGTAAATGTTTTATTAGTTCATTGC
CTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCTCTTTGATTTTTAAAGTTTTGGGGTGGG
GGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAAAGAGAATAGTGTTCACAAAATTTGAGC
TGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTTTCCTCTCCACCATCTCACATTTTGCTT
TTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTCATCCTTAAAGTTTACTCCACTTTGACA
AAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTAGGTAGACTTTACCCAGTCTCTTTCCTT
TTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCTCGCTTGCTCGCTCTC
GCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGGATAATTCTTTACTTTTTTTGAAATAAA
GGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTTTTTAAACCATGTTCTGATGGGGAAGTT
GATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCATTCCTAGAGGGCTAATAACAGCATTTAG

>In-frame_ENST00000586881_ENST00000430627_TCGA-V5-A7RE-11A_USP32_chr17_58378959_-_CDK12_chr17_37646809_length(amino acids)=802AA_start in transcript=435_stop in transcript=2843
MSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPI
TAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRD
IKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELIS
RLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPH
EHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARV

--------------------------------------------------------------
>In-frame_ENST00000586881_ENST00000447079_TCGA-V5-A7RE-11A_USP32_chr17_58378959_-_CDK12_chr17_37646809_length(transcript)=6701nt_BP=329nt
AGCAGATGCTGGTGCCATGCTTATACAGGCTGCAGAACCGTGAGCCAAAAAAACCTCTTTTCTTTATAAAAATTACCCAGCCTCAGGTTA
AAATTCTGACTCTGCTGCTTCATTGATGTATGACTTTGGACAAGTTACTTAATCTCTTTGGGCTCTGGTTTCCCCCAGCCCTAAAATGAG
GATACCAGTATTCCTTGTGGAGTCATCTAAAGGCTTAATACTGGTGATTTACTGTTCTTTTGGTGGAACATCCAAAGGGCTGCACTTCAA
TAATTTAATAGTTGGACTTGTCCTCCTTACAAGAGGCAAAGATGAAGAGAAAGCAAAATTCCAAAAGAAACTCTTCCTTCAAAACCTGTG
AAGAAAGAGAAGGAACAGAGGACACGTCACTTACTCACAGACCTTCCTCTCCCTCCAGAGCTCCCTGGTGGAGATCTGTCTCCCCCAGAC
TCTCCAGAACCAAAGGCAATCACACCACCTCAGCAACCATATAAAAAGAGACCAAAAATTTGTTGTCCTCGTTATGGAGAAAGAAGACAA
ACAGAAAGCGACTGGGGGAAACGCTGTGTGGACAAGTTTGACATTATTGGGATTATTGGAGAAGGAACCTATGGCCAAGTATATAAAGCC
AAGGACAAAGACACAGGAGAACTAGTGGCTCTGAAGAAGGTGAGACTAGACAATGAGAAAGAGGGCTTCCCAATCACAGCCATTCGTGAA
ATCAAAATCCTTCGTCAGTTAATCCACCGAAGTGTTGTTAACATGAAGGAAATTGTCACAGATAAACAAGATGCACTGGATTTCAAGAAG
GACAAAGGTGCCTTTTACCTTGTATTTGAGTATATGGACCATGACTTAATGGGACTGCTAGAATCTGGTTTGGTGCACTTTTCTGAGGAC
CATATCAAGTCGTTCATGAAACAGCTAATGGAAGGATTGGAATACTGTCACAAAAAGAATTTCCTGCATCGGGATATTAAGTGTTCTAAC
ATTTTGCTGAATAACAGTGGGCAAATCAAACTAGCAGATTTTGGACTTGCTCGGCTCTATAACTCTGAAGAGAGTCGCCCTTACACAAAC
AAAGTCATTACTTTGTGGTACCGACCTCCAGAACTACTGCTAGGAGAGGAACGTTACACACCAGCCATAGATGTTTGGAGCTGTGGATGT
ATTCTTGGGGAACTATTCACAAAGAAGCCTATTTTTCAAGCCAATCTGGAACTGGCTCAGCTAGAACTGATCAGCCGACTTTGTGGTAGC
CCTTGTCCAGCTGTGTGGCCTGATGTTATCAAACTGCCCTACTTCAACACCATGAAACCGAAGAAGCAATATCGAAGGCGTCTACGAGAA
GAATTCTCTTTCATTCCTTCTGCAGCACTTGATTTATTGGACCACATGCTGACACTAGATCCTAGTAAGCGGTGCACAGCTGAACAGACC
CTACAGAGCGACTTCCTTAAAGATGTCGAACTCAGCAAAATGGCTCCTCCAGACCTCCCCCACTGGCAGGATTGCCATGAGTTGTGGAGT
AAGAAACGGCGACGTCAGCGACAAAGTGGTGTTGTAGTCGAAGAGCCACCTCCATCCAAAACTTCTCGAAAAGAAACTACCTCAGGGACA
AGTACTGAGCCTGTGAAGAACAGCAGCCCAGCACCACCTCAGCCTGCTCCTGGCAAGGTGGAGTCTGGGGCTGGGGATGCAATAGGCCTT
GCTGACATCACACAACAGCTGAATCAAAGTGAATTGGCAGTGTTATTAAACCTGCTGCAGAGCCAAACCGACCTGAGCATCCCTCAAATG
GCACAGCTGCTTAACATCCACTCCAACCCAGAGATGCAGCAGCAGCTGGAAGCCCTGAACCAATCCATCAGTGCCCTGACGGAAGCTACT
TCCCAGCAGCAGGACTCAGAGACCATGGCCCCAGAGGAGTCTTTGAAGGAAGCACCCTCTGCCCCAGTGATCCTGCCTTCAGCAGAACAG
ACGACCCTTGAAGCTTCAAGCACACCAGCTGACATGCAGAATATATTGGCAGTTCTCTTGAGTCAGCTGATGAAAACCCAAGAGCCAGCA
GGCAGTCTGGAGGAAAACAACAGTGACAAGAACAGTGGGCCACAGGGGCCCCGAAGAACTCCCACAATGCCACAGGAGGAGGCAGCAGCA
TGTCCTCCTCACATTCTTCCACCAGAGAAGAGGCCCCCTGAGCCCCCCGGACCTCCACCGCCGCCACCTCCACCCCCTCTGGTTGAAGGC
GATCTTTCCAGCGCCCCCCAGGAGTTGAACCCAGCCGTGACAGCCGCCTTGCTGCAACTTTTATCCCAGCCTGAAGCAGAGCCTCCTGGC
CACCTGCCACATGAGCACCAGGCCTTGAGACCAATGGAGTACTCCACCCGACCCCGTCCAAACAGGACTTATGGAAACACTGATGGGCCT
GAAACAGGGTTCAGTGCCATTGACACTGATGAACGAAACTCTGGTCCAGCCTTGACAGAATCCTTGGTCCAGACCCTGGTGAAGAACAGG
ACCTTCTCAGGCTCTCTGAGCCACCTTGGGGAGTCCAGCAGTTACCAGGGCACAGGGTCAGTGCAGTTTCCAGGGGACCAGGACCTCCGT
TTTGCCAGGGTCCCCTTAGCGTTACACCCGGTGGTCGGGCAACCATTCCTGAAGGCTGAGGGAAGCAGCAATTCTGTGGTACATGCAGAG
ACCAAATTGCAAAACTATGGGGAGCTGGGGCCAGGAACCACTGGGGCCAGCAGCTCAGGAGCAGGCCTTCACTGGGGGGGCCCAACTCAG
TCTTCTGCTTATGGAAAACTCTATCGGGGGCCTACAAGAGTCCCACCAAGAGGGGGAAGAGGGAGAGGAGTTCCTTACTAACCCAGAGAC
TTCAGTGTCCTGAAAGATTCCTTTCCTATCCATCCTTCCATCCAGTTCTCTGAATCTTTAATGAAATCATTTGCCAGAGCGAGGTAATCA
TCTGCATTTGGCTACTGCAAAGCTGTCCGTTGTATTCCTTGCTCACTTGCTACTAGCAGGCGACTTACGAAATAATGATGTTGGCACCAG
TTCCCCCTGGATGGGCTATAGCCAGAACATTTACTTCAACTCTACCTTAGTAGATACAAGTAGAGAATATGGAGAGGATCATTACATTGA
AAAGTAAATGTTTTATTAGTTCATTGCCTGCACTTACTGATCGGAAGAGAGAAAGAACAGTTTCAGTATTGAGATGGCTCAGGAGAGGCT
CTTTGATTTTTAAAGTTTTGGGGTGGGGGATTGTGTGTGGTTTCTTTCTTTTGAATTTTAATTTAGGTGTTTTGGGTTTTTTTCCTTTAA
AGAGAATAGTGTTCACAAAATTTGAGCTGCTCTTTGGCTTTTGCTATAAGGGAAACAGAGTGGCCTGGCTGATTTGAATAAATGTTTCTT
TCCTCTCCACCATCTCACATTTTGCTTTTAAGTGAACACTTTTTCCCCATTGAGCATCTTGAACATACTTTTTTTCCAAATAAATTACTC
ATCCTTAAAGTTTACTCCACTTTGACAAAAGATACGCCCTTCTCCCTGCACATAAAGCAGGTTGTAGAACGTGGCATTCTTGGGCAAGTA
GGTAGACTTTACCCAGTCTCTTTCCTTTTTTGCTGATGTGTGCTCTCTCTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT
CTCTCTCTGTCTCGCTTGCTCGCTCTCGCTGTTTCTCTCTCTTTGAGGCATTTGTTTGGAAAAAATCGTTGAGATGCCCAAGAACCTGGG
ATAATTCTTTACTTTTTTTGAAATAAAGGAAAGGAAATTCAGACTCTTACATTGTTCTCTGTAACTCTTCAATTCTAAAATGTTTTGTTT
TTTAAACCATGTTCTGATGGGGAAGTTGATTTGTAAGTGTGGACAGCTTGGACATTGCTGCTGAGCTGTGGTTAGAGATGATGCCTCCAT
TCCTAGAGGGCTAATAACAGCATTTAGCATATTGTTTACACATATATTTTTATGTCAAAAAAAAAACAAAAACCTTTCAAACAGAGCATT
GTGATATTGTCAAAGAGAAAAACAAATCCTGAAGATACATGGAAATGTAACCTAGTTTAGGGTGGGTATTTTTCTGAAGATACATCAATA
CCTGACCTTTTTTAAAAAAATAATTTTAAAACAGCATACTGTGAGGAAGAACAGTATTGACATACCCACATCCCAGCATGTGTACCCTGC
CAGTTCTTTTAGGGATTTTTCCTCCAAAGAGATTTGGATTTGGTTTTGGTAAAAGGGGTTAAATTGTGCTTCCAGGCAAGAACTTTGCCT
TATCATAAACAGGAAATGAAAAAGGGAAGGGCTGTCAGGATGGGATAATTTGGGAGGCTTCTCATTCTGGCTTCTATTTCTATGTGAGTA
CCAGCATATAGAGTGTTTTAAAAACAGATACATGTCATATAATTTATCTGCACAGACTTAGACCTTCAGGAAACATAGGTTAAGCCCCCT
TTTACAAAGAAAAAGTAAACATACTTCAGCATCTTGGAGGGTAGTTTTCAAAACTCAAGTTTCATGTTTCAATGCCAAGTTCTTATTTTA
AAAAATAAAATCTACTTATAAGAGAAAGGTGCATTACTTAAAAAAAAAAAACTTTAAAGAAATGAAAGAAGAACCCTCTTCAGATACTTA
CTTGAAGACTGTTTTCCCCTGTTAATGAGATATAGCTAGATATCGGTGTGTGTATTTCTTTATTATTCTCTGGTTTTTGATCTGGCCTTG
CCTCCAGGGCCAAACACTGATTTAGAAAGAGAGCCTTCTAGCTATTTTGGCATTGATGGCTTTTTATACCAGTGTGTCCAGTTAGATTTA
CTAGGCTTACTGACATGCTATTGGTAAATCGCATTAAAGTTCATCTGAACCTTCTGTCTGTTGACTTCTTAGTCCTCAGACATGGGCCTT
TGTGTTTTAGAATATTTGAATTTGAGTTATTGGGCCCCACTCCCTGTTTTTTATTAAAGAACGTGAGCCTGGGATACTTTCAGAAGTATC
TGTTCAATGAAAAAAAGTTGGTTTCCCATCAAATATGAATAAAATTCTCTATATATTTCATTGTATTTTGGTTATCAGCAGTCATCAATA
ATGTTTTTCCCTCCCCTCTCCCACCTCTTATTTTTAATTATGCCAAATATCCTAAATAATATACTTAAGCCTCCATTCCCTCATCCCTAC
TAGGGAAGGGGGTGAGTGTATGTGTGAGTGTATGTGTATGTATGATCCCATCTCACCCCCACCCCCATTTTGGGAGTCTTTTAAAATGAA
AACAAAGTTTGGTAGTTTTGACTATTTCTAAAAGCAGAGGAGAAAAAAAAACTTATTTAAATATCCTGGAATCTGTATGGAGGAAGAAAA
GGTATTTGTTAATTTTTCAGTTACGTTATCTATAAACATGATGGAAGTAAAGGTTTGGCAGAATTTCACCTTGACTATTTGAAAATTACA
GACCCAATTAATTCCATTCAAAAGTGGTTTTCGTTTTGTTTTAATTATTGTACAATGAGAGATATTGTCTATTAAATACATTATTTTGAA
CAGATGAGAAATCTGATTCTGTTCATGAGTGGGAGGCAAAACTGGTTTGACCGTGATCATTTTTGTGGTTTTGAAAACAAATATACTTGA
CCCAGTTTCCTTAGTTTTTTCTTCAACTGTCCATAGGAACGATAAGTATTTGAAAGCAACATCAAATCTATACGTTTAAAGCAGGGCAGT
TAGCACAAATTTGCAAGTAGAACTTCTATTAGCTTATGCCATAGACATCACCCAACCACTTGTATGTGTGTGTGTATATATAATATGCAT
ATATAGTTACCGTGCTAAAATGGTTACCAGCAGGTTTTGAGAGAGAATGCTGCATCAGAAAAGTGTCAGTTGCCACCTCATTCTCCCTGA
TTTAGGTTCCTGACACTGATTCCTTTCTCTCTCGTTTTTGACCCCCATTGGGTGTATCTTGTCTATGTACAGATATTTTGTAATATATTA
AATTTTTTTCTTTCAGTTTATAAAAATGGAAAGTGGAGATTGGAAAATTAAATATTTCCTGTTACTATACCACTTTTGCTCCATTGCATT
TACTTCTTAATCTGTACCCCCTGAGCATATCTAATCATGTATAAAGGACGTTTTTCCTCCACTTTATCTTAGGGGTTCTCTGTCTCAGAA
TCATTATAGACTCATTAACTCCCCCTCCCAGCAAAAGGTTATCAGGATTTGAAGAGGTGCTTGAAAACGCTAGACTAGGAACTAGAGAAT
AAATGAGTTGGGAAAAACCATGAAATGTGATTTTTTTAAAGTAGAAAAGTTATACAAATAATGGTACCAAACCATCAAAAGAGTTGAGCT
TCATGTACCCTGACTCCTCCTGACAGGAGAGGTAAGTGGGTTTGAGCTCAACTGTCATCAAGGGAAGTTGGTAAGAGGCTGTTTAGACCC
AAAGGATAGTCTTAAACCAGACTTCACCACCCACCCTACCTCAGTTCCCATGTTATTACATGCAGAGTCAGCATGGGGATTAGTGTACCT
ACCTTTGCTGAGATTTCCCGATGCGTTGCCAATCCAGAAAGTGAATCAAAAAGTTGTTTAAAAGTTAAAATCTCTATTGTTTCCAAAATC

>In-frame_ENST00000586881_ENST00000447079_TCGA-V5-A7RE-11A_USP32_chr17_58378959_-_CDK12_chr17_37646809_length(amino acids)=811AA_start in transcript=435_stop in transcript=2870
MSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPI
TAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRD
IKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELIS
RLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDC
HELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDL
SIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK
TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPE
AEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPG
DQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVP

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Fusion Gene PPI Analysis for USP32-CDK12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP32-CDK12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP32-CDK12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSP32C4721610Carcinoma, Ovarian Epithelial1CTD_human
TgeneCDK12C0033578Prostatic Neoplasms1CTD_human
TgeneCDK12C0376358Malignant neoplasm of prostate1CTD_human