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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP34-PLEKHG1 (FusionGDB2 ID:96756)

Fusion Gene Summary for USP34-PLEKHG1

check button Fusion gene summary
Fusion gene informationFusion gene name: USP34-PLEKHG1
Fusion gene ID: 96756
HgeneTgene
Gene symbol

USP34

PLEKHG1

Gene ID

9736

57480

Gene nameubiquitin specific peptidase 34pleckstrin homology and RhoGEF domain containing G1
Synonyms-ARHGEF41
Cytomap

2p15

6q25.1

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34pleckstrin homology domain-containing family G member 1pleckstrin homology domain containing, family G (with RhoGef domain) member 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000398571, ENST00000472689, 
ENST00000367328, ENST00000358517, 
Fusion gene scores* DoF score30 X 29 X 14=1218011 X 13 X 5=715
# samples 3712
** MAII scorelog2(37/12180*10)=-5.04084505227738
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/715*10)=-2.57490883605723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP34 [Title/Abstract] AND PLEKHG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP34(61647881)-PLEKHG1(151107526), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP34

GO:0016579

protein deubiquitination

14715245

HgeneUSP34

GO:0071108

protein K48-linked deubiquitination

21383061

HgeneUSP34

GO:0090263

positive regulation of canonical Wnt signaling pathway

21383061


check buttonFusion gene breakpoints across USP34 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PLEKHG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-2401-01AUSP34chr2

61647881

-PLEKHG1chr6

151107526

+
ChimerDB4OVTCGA-25-2401-01AUSP34chr2

61647881

-PLEKHG1chr6

151107526

+


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Fusion Gene ORF analysis for USP34-PLEKHG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000398571ENST00000367328USP34chr2

61647881

-PLEKHG1chr6

151107526

+
In-frameENST00000398571ENST00000358517USP34chr2

61647881

-PLEKHG1chr6

151107526

+
intron-3CDSENST00000472689ENST00000367328USP34chr2

61647881

-PLEKHG1chr6

151107526

+
intron-3CDSENST00000472689ENST00000358517USP34chr2

61647881

-PLEKHG1chr6

151107526

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398571USP34chr261647881-ENST00000367328PLEKHG1chr6151107526+66212087738531258
ENST00000398571USP34chr261647881-ENST00000358517PLEKHG1chr6151107526+66212087738531258

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398571ENST00000367328USP34chr261647881-PLEKHG1chr6151107526+0.0002056590.9997943
ENST00000398571ENST00000358517USP34chr261647881-PLEKHG1chr6151107526+0.0002056590.9997943

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Fusion Genomic Features for USP34-PLEKHG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USP34chr261647880-PLEKHG1chr6151107525+0.0009616460.99903834
USP34chr261647880-PLEKHG1chr6151107525+0.0009616460.99903834

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP34-PLEKHG1


check button Go to

FGviewer for the breakpoints of chr2:61647881-chr6:151107526

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePLEKHG1chr2:61647881chr6:151107526ENST00000358517216317_416170.666666666666661386.0DomainPH
TgenePLEKHG1chr2:61647881chr6:151107526ENST00000367328317317_416170.666666666666661386.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP34chr2:61647881chr6:151107526ENST00000398571-2801894_223943.6666666666666643547.0DomainNote=USP
TgenePLEKHG1chr2:61647881chr6:151107526ENST00000358517216113_293170.666666666666661386.0DomainDH
TgenePLEKHG1chr2:61647881chr6:151107526ENST00000367328317113_293170.666666666666661386.0DomainDH


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Fusion Gene Sequence for USP34-PLEKHG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000398571_ENST00000367328_TCGA-25-2401-01A_USP34_chr2_61647881_-_PLEKHG1_chr6_151107526_length(transcript)=6621nt_BP=208nt
TCTCTCCCCTCCCCCCCGCCGGTCGGGATCAGTCAGTGTGATCCGAAGCGGGGGAGGGGGGGGGCGGCGGCCGAACGATGTGCGAGAACT
GCGCAGACCTGGTGGAGGTGTTAAATGAAATATCAGATGTAGAAGGTGGTGATGGACTGCAGCTCAGAAAGGAACATACTCTCAAAATAT
TTACTTATATCAATTCCTGGACACAGAGTGAACTTCTGCAAGATTTGGAAAACTGTGAAAATGATCCTGTGGCCATAGCAGAGTGTTTTG
TGTCCAAGAGTGAAGAGTTCCACATTTATACCCAGTATTGCACTAACTATCCAAGGTCCGTGGCTGTGCTAACAGAGTGTATGAGGAACA
AGATACTGGCCAAATTCTTCAGGGAGCGTCAGGAAACTCTGAAACACTCGCTGCCTCTGGGGTCCTATCTCTTGAAACCAGTTCAGCGGA
TTCTCAAGTATCATCTCCTTCTGCATGAAATAGAAAACCACCTTGATAAGGACACAGAAGGCTATGATGTGGTGCTTGATGCTATAGACA
CAATGCAGCGAGTCGCCTGGCATATCAATGACATGAAGCGGAAACACGAGCACGCGGTCCGGTTACAGGAGATACAGAGTTTGCTCACTA
ACTGGAAGGGGCCAGACCTGACCAGCTACGGGGAACTGGTGCTTGAGGGAACCTTCCGCATCCAGCGAGCCAAGAATGAGCGGACGCTCT
TCCTCTTCGACAAGCTGCTGCTCATCACGAAGAAGAGAGATGACACGTTTACATACAAAGCTCACATCCTGTGTGGCAACCTCATGCTTG
TGGAGGTGATTCCAAAAGAGCCGCTCAGCTTCAGCGTCTTCCACTACAAGAATCCCAAGCTGCAGCACACAGTCCAGGCCAAATCCCAGC
AAGACAAACGCCTCTGGGTTCTGCACCTAAAGAGACTGATTCTGGAGAACCATGCAGCCAAGATTCCAGCTAAGGCCAAGCAAGCAATCC
TTGAAATGGATGCCATTCATCATCCAGGCTTCTGTTACAGTCCTGAGGGAGGGACGAAAGCACTGTTCGGCTCTAAAGAAGGTTCTGCTC
CATATCGGCTGAGAAGAAAATCTGAACCTTCCTCACGGTCACATAAAGTTTTGAAGACCAGTGAAACAGCACAAGACATCCAAAAGGTTT
CTAGAGAGGAAGGATCTCCCCAGCTGTCTTCAGCAAGGCCGTCTCCTGCCCAGAGAAATAGTCAGCCTAGCAGTTCTACCATGATCAGCG
TGCTTCGAGCGGGTGGAGCTCTCAGAAACATCTGGACCGATCACCAGATCAGGCAAGCCTTGTTTCCCAGCCGACGGTCCCCGCAGGAGA
ATGAGGATGATGAAGATGATTATCAGATGTTCGTGCCGTCATTTTCCTCCTCAGATCTGAACTCTACCAGACTATGTGAAGATAGCACTT
CTAGTCGCCCTTGCAGCTGGCATATGGGACAGATGGAGTCCACAGAGACCTCCAGCTCTGGTCACAGGATTGTCAGGCGGGCCAGCAGTG
CTGGGGAGAGCAACACATGCCCTCCTGAAATAGGAACTAGTGACAGAACTAGGGAACTGCAGAACAGCCCCAAAACAGAAGGGCAGGAGG
AGATGACTCCCTTTGGGTCATCCATAGAGTTGACTATTGATGACATAGACCATGTCTATGATAACATCAGTTATGAGGACTTAAAACTAA
TGGTTGCTAAGCGGGAAGAAGCTGAATCCACTCCCTCTAAATCAGCCAGGGACTCCGTTCGCCCCAAGAGCACCCCAGAGTTAGCCTTCA
CAAAGAGGCAAGCTGGCCACAGTAAGGGCTCTCTTTACGCACAAACAGATGGCACCCTCTCAGGTGGAGAGGCATCCAGCCAAAGCACGC
ATGAACTCCAAGCGGTTGAGGAGAACATCTATGACACCATAGGGCTCCCAGATCCTCCGTCGCTGGGTTTTAAGTGCAGCAGCCTAAAGC
GTGCAAAGCGGAGCACCTTTTTGGGTCTGGAGGCCGACTTCGTGTGCTGTGACAGCCTGAGGCCATTTGTTTCCCAAGACAGCCTCCAGC
TCAGTGAGGACGAAGCCCCTTACCATCAGGCCACTCCCGATCATGGTTATCTGAGTTTGCTGTATGACTCTCCCAGTGGTAACTTGTCTA
TGCCTCATAAGCCTGTATCTGATAAACTGTCCGAAGAAGTAGATGAAATCTGGAATGACCTGGAAAATTACATCAAGAAAAATGAAGACA
AGGCCAGAGACCGTCTCCTGGCAGCGTTTCCTGTGAGCAAGGATGATGTGCCAGACAGGCTGCACGCAGAGAGCACCCCTGAGCTGAGCC
GGGACGTGGGGCGCTCTGTGTCCACGCTGTCCCTGCCTGAGAGCCAGGCTCTCCTCACGCCCGTGAAGAGCAGGGCTGGCAGAGCCAGCC
GCGCCAACTGCCCCTTTGAGGAAGACCTGATTTCTAAAGAAGGCTCCTTTATGAGCCTTAACCGGCTTTCTCTGGCTAGTGAAATGCCCC
TCATGGACAATCCCTACGACCTGGCCAACAGTGGCCTGTCTCAAACAGACCCAGAAAACCCTGACCTGGGGATGGAGGCCACAGATAAGA
CAAAAAGCAGGGTGTTTATGATGGCTCGGCAGTACAGTCAGAAGATTAAGAAGGCGAATCAACTTTTAAAAGTGAAAAGTCTGGAGCTGG
AGCAGCCGCCGGCCAGTCAGCATCAGAAATCCATGCACAAAGACCTGGCTGCCATCTTGGAAGAGAAGAAGCAAGGAGGGCCCGCCATTG
GTGCCAGGATTGCTGAGTATTCCCAGTTGTATGACCAGATTGTATTCAGAGAGTCTCCCTTGAAAATTCAGAAGGATGGCTGGGCCAGCC
CTCAAGAATCCTCCCTCCTGAGGTCTGTGTCACCTTCCCAGGTCCACCATGGTAGTGGAGACTGGCTTCTGCATTCAACCTATAGTAATG
GAGAGTTAGCAGATTTCTGTCTCCCACCAGAGCAAGACTTGAGGTCAAGATATCCCACGTTTGAGATCAATACAAAAAGTACTCCCAGGC
AATTGTCCGCAGCTTGCTCTGTGCCTTCTCTTCAAACCTCTGACCCTCTGCCAGGCTCTGTGCAGAGATGCAGCGTGGTAGTAAGTCAGC
CCAACAAAGAGAACTGGTGTCAGGACCATCTTTACAACTCCTTGGGTCGGAAAGGGATCAGCGCTAAATCTCAGCCTTATCACAGGTCCC
AGTCATCTTCCTCCGTCTTGATCAACAAATCAATGGATTCCATCAACTACCCTAGTGATGTGGGAAAGCAGCAGCTGCTGTCTTTACACA
GAAGTTCAAGGTGTGAGAGTCACCAGGACTTGCTGCCAGATATTGCTGACTCGCATCAACAGGGCACTGAAAAACTCTCAGATCTCACAC
TCCAAGACTCACAGAAAGTTGTGGTGGTCAATAGAAATTTACCCTTAAATGCCCAAATTGCAACACAGAATTATTTTTCCAATTTCAAAG
AGACTGATGGAGATGAAGATGACTATGTGGAAATCAAGTCAGAAGAAGATGAGTCGGAGTTGGAGCTATCTCACAATCGTAGAAGGAAAT
CTGACTCAAAGTTTGTGGATGCTGACTTTTCTGATAATGTCTGCAGCGGCAACACATTGCATTCTTTGAATAGTCCGCGCACTCCAAAAA
AGCCGGTTAACAGCAAACTTGGCCTTTCACCATATCTGACACCATATAATGATTCTGACAAACTGAATGACTATCTTTGGAGGGGGCCAT
CTCCCAATCAACAAAATATTGTCCAGTCTCTAAGGGAAAAATTTCAGTGTCTCAGTTCAAGCAGCTTTGCTTAAGGTTCTTCATAATAAC
TGCTTGAATCAACTTCTTATTTTGCTCATAAAACGTTACAGATACTGATGAGGTGTTTTATGTATACCAGATTAAAACAATTTTGTAAGA
ACCAGAGGTGTAAAATATACTTTCTTTTACAGCACAACTTTTGGAAATGGCTGACGATGCAGCCCGGATTGTACTGTAGCACATGTTGGC
ATCAACAGTATATTTTCTCATGCTGAGTGTCTTCATGTTTCATGTAAGTCAATCTTACTTGAAAGTTTTTAGACTTTTAACACGATGGCC
ATAACCTGACAATAGTGCCCACACCTTAAGAAATGCAATAATCCTTTCCTGTTATCCAGAAGGCCCAGGTAGTTTTATCCTGTGACTCAA
AGGCAGCAAGGAGACTTTTTCACATTTTAAAAGGCAACGAAAGCTGTTGAAAGAATTATGCTTATATCTCACATTTTGGTTATATTTGTG
GTAACACCTTAGGATAACGTAAGCCAGAGATCTGTAAATTGGACTGCAGTCTGAGGTGCCCATTTTAGGGTTTTTGTGCTAGTATTCTTT
TATGTCATTTTGATGCAGAAATTGTGTGACTGTTGAAAATTAAAATGTAGCGGGACCCATTTTCTGTACGCAGAACCCTTTACCTGTATT
CCTGGACAAGGCCTAGAGAACGAGCTGCTCATCATGTTTCTAATATAATTTCTGGGGTGAAATGAATGATTTCCTTACTGGCTTAGAGAA
AACCAAGGTCAATAAAATGCAGATTGACTTAACTATTAGAAAAGATGGGATGACTTCTGGGAACCACTTAACTCTTCAAATGACTGTTGA
AAGAGAAAAAGCAAAACTGAAATCCCACCAGACCATTTTGTGTGCCTGTTTCTAATCGATACAAAGTTAAGCATGAGCTAAAATCAGACA
AAGCACTTTAAATTTATCCTTTCCAGAGCGCTTTGCACATGCACCCTCCTGAGTTTGGGATTCTGCCAAATGACCAACTTGATCCTGGCC
CTGAGGAGTCATTGGCTGCAGGAATAGGGCAAGAATCTATTTCCTAAACTACACATAACATGGGAGCCTTTTTTTCGTTGTTTTCAGGTA
TATTAAAGAATGAAATCTTTGGTTACTAGGTGCTGACTAATAAATAACACCTTTTATATTCTGACCATTTGTCACATTTCATTGTGATAC
TGTATACTGATCTAACTCCTTATGAAAGGCAACAAACAAAAATAAGACATTGAATAAAAAGCAAAATCAAAGAAGCTAAAGAGAAAAATG
AAGGCAGATATATTGCAACTTTATAACATATTCTATTTTATTGAAGACTGCAATTAATGCAGCAAGAATGCTTTCTCAAGCGGTGGCCTT
TGTATTCTCATTTTAATCAGGTGTACATTCTATGGCCTCTCCCCCATGCTGTTAGTTTCTATTTTAAAAGATACAATAATATATGTAGGG
AAAGGGGCCTGGGCTCTTCATTTAAAGGTAAGCAGTAATATTGAGTAAGTGACATAATTCTTTTTCTCTTTGTTAAGTCCTATGCCTCTT
TTTCTTAACTGTAAAACATAGAATATGAGCGTTTTTATCTTACAAATAGGTACCTAAGGCATGTGATTTTATTTTTAAATAACAAAAAAT
AACCCAAGTTTCTTGCTTCTCCAAAGTATTCTTCTCATAGCTTATAAAAGAAAGTCCACATTGAATAGCATGGTCTGGGAACATTCCTTC
TTTATTGTGTTTATTTGAACATGATATGAGTTTCCAAGATGAAATGATCAAAAAAGATAAGTACCACAAGAAAGTTTTTTTGTTTGGTTG
GTTTTTTTGTTTGTTTGTTTTTTTCTTGAGACTGAGTCTCTCCCTGTTGCCCAAGTTGGAGTGCAATCTTGGCTCACTGCAGCCTCCACC
TCCCCGGTTCCAGCGATTCTCCTGCCTCAGCCTCTTGAATAGCTGGGATTACAGGCGCCCGCCACCACACCTGGCTAATTTTTGTGTTGT
TAGTAGAGGCGGGGTTTCATCATGTTGGCCAGGCTGGTCTCGAACTCCTGATCTCATGATCCGTCTGCCTCGGCCTCCCAGAGTGCTGGG
ATTACAGGCATGAGCCACTGCGCCCGGCCAAGAAAGTATGTTTTTAGAGGTGTGTGTAAGTGCATTTGTATTACCTATGAACAAAATTAC
CTGACTCTTGTCCCAGGAAAGCTGTTTCGCATTTTCGCTTTTTGATTGGTATTATCCAGTTCTATGTAGTTCATATTATTGTTCTGTCTG
ACTCTCAGAAATTACTTCTTCACGCCAGTGTCTTGTTGCATGACTTTGATGTCACCTATAGGAATACACCTCACTGCACGTAAGTGGGTA
TCTTACTGTATAAAAGGTCTACATGGCTTTAGGTTTTAGGACAAATGTGTAGATTTATAGACCATTTCTGTTGGCCAGGACACAGATTTT
GAGAGCTGTGTGTATATATATATAATCATGTTTGTATTTTTTTCCTGAAAGTTATCAATTGCTTTTGTTTAAAACAGTTTGTTTTAGAGG
TGGGGTGGGGATGTATATAACGAGGAAAAGTTATATGTACTTTAAAGTATGTCAAGTTCTTACTAGTTTCCTGTACTGAAGGTTCAATTT
TTTTTATATAAGTTTACTTTTCACCTGCTCTATTCTTTGTGGGGAAAAAATGCATCTAGAAAAACATAGTTTAAATACTGTATATAAGAT

>In-frame_ENST00000398571_ENST00000367328_TCGA-25-2401-01A_USP34_chr2_61647881_-_PLEKHG1_chr6_151107526_length(amino acids)=1258AA_start in transcript=77_stop in transcript=3853
MCENCADLVEVLNEISDVEGGDGLQLRKEHTLKIFTYINSWTQSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTE
CMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQ
SLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQ
AKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLKTSETAQD
IQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLC
EDSTSSRPCSWHMGQMESTETSSSGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHVYDNISYE
DLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGTLSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKC
SSLKRAKRSTFLGLEADFVCCDSLRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWNDLENYIK
KNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALLTPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLA
SEMPLMDNPYDLANSGLSQTDPENPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAILEEKKQG
GPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGSGDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTK
STPRQLSAACSVPSLQTSDPLPGSVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPSDVGKQQL
LSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQIATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHN

--------------------------------------------------------------
>In-frame_ENST00000398571_ENST00000358517_TCGA-25-2401-01A_USP34_chr2_61647881_-_PLEKHG1_chr6_151107526_length(transcript)=6621nt_BP=208nt
TCTCTCCCCTCCCCCCCGCCGGTCGGGATCAGTCAGTGTGATCCGAAGCGGGGGAGGGGGGGGGCGGCGGCCGAACGATGTGCGAGAACT
GCGCAGACCTGGTGGAGGTGTTAAATGAAATATCAGATGTAGAAGGTGGTGATGGACTGCAGCTCAGAAAGGAACATACTCTCAAAATAT
TTACTTATATCAATTCCTGGACACAGAGTGAACTTCTGCAAGATTTGGAAAACTGTGAAAATGATCCTGTGGCCATAGCAGAGTGTTTTG
TGTCCAAGAGTGAAGAGTTCCACATTTATACCCAGTATTGCACTAACTATCCAAGGTCCGTGGCTGTGCTAACAGAGTGTATGAGGAACA
AGATACTGGCCAAATTCTTCAGGGAGCGTCAGGAAACTCTGAAACACTCGCTGCCTCTGGGGTCCTATCTCTTGAAACCAGTTCAGCGGA
TTCTCAAGTATCATCTCCTTCTGCATGAAATAGAAAACCACCTTGATAAGGACACAGAAGGCTATGATGTGGTGCTTGATGCTATAGACA
CAATGCAGCGAGTCGCCTGGCATATCAATGACATGAAGCGGAAACACGAGCACGCGGTCCGGTTACAGGAGATACAGAGTTTGCTCACTA
ACTGGAAGGGGCCAGACCTGACCAGCTACGGGGAACTGGTGCTTGAGGGAACCTTCCGCATCCAGCGAGCCAAGAATGAGCGGACGCTCT
TCCTCTTCGACAAGCTGCTGCTCATCACGAAGAAGAGAGATGACACGTTTACATACAAAGCTCACATCCTGTGTGGCAACCTCATGCTTG
TGGAGGTGATTCCAAAAGAGCCGCTCAGCTTCAGCGTCTTCCACTACAAGAATCCCAAGCTGCAGCACACAGTCCAGGCCAAATCCCAGC
AAGACAAACGCCTCTGGGTTCTGCACCTAAAGAGACTGATTCTGGAGAACCATGCAGCCAAGATTCCAGCTAAGGCCAAGCAAGCAATCC
TTGAAATGGATGCCATTCATCATCCAGGCTTCTGTTACAGTCCTGAGGGAGGGACGAAAGCACTGTTCGGCTCTAAAGAAGGTTCTGCTC
CATATCGGCTGAGAAGAAAATCTGAACCTTCCTCACGGTCACATAAAGTTTTGAAGACCAGTGAAACAGCACAAGACATCCAAAAGGTTT
CTAGAGAGGAAGGATCTCCCCAGCTGTCTTCAGCAAGGCCGTCTCCTGCCCAGAGAAATAGTCAGCCTAGCAGTTCTACCATGATCAGCG
TGCTTCGAGCGGGTGGAGCTCTCAGAAACATCTGGACCGATCACCAGATCAGGCAAGCCTTGTTTCCCAGCCGACGGTCCCCGCAGGAGA
ATGAGGATGATGAAGATGATTATCAGATGTTCGTGCCGTCATTTTCCTCCTCAGATCTGAACTCTACCAGACTATGTGAAGATAGCACTT
CTAGTCGCCCTTGCAGCTGGCATATGGGACAGATGGAGTCCACAGAGACCTCCAGCTCTGGTCACAGGATTGTCAGGCGGGCCAGCAGTG
CTGGGGAGAGCAACACATGCCCTCCTGAAATAGGAACTAGTGACAGAACTAGGGAACTGCAGAACAGCCCCAAAACAGAAGGGCAGGAGG
AGATGACTCCCTTTGGGTCATCCATAGAGTTGACTATTGATGACATAGACCATGTCTATGATAACATCAGTTATGAGGACTTAAAACTAA
TGGTTGCTAAGCGGGAAGAAGCTGAATCCACTCCCTCTAAATCAGCCAGGGACTCCGTTCGCCCCAAGAGCACCCCAGAGTTAGCCTTCA
CAAAGAGGCAAGCTGGCCACAGTAAGGGCTCTCTTTACGCACAAACAGATGGCACCCTCTCAGGTGGAGAGGCATCCAGCCAAAGCACGC
ATGAACTCCAAGCGGTTGAGGAGAACATCTATGACACCATAGGGCTCCCAGATCCTCCGTCGCTGGGTTTTAAGTGCAGCAGCCTAAAGC
GTGCAAAGCGGAGCACCTTTTTGGGTCTGGAGGCCGACTTCGTGTGCTGTGACAGCCTGAGGCCATTTGTTTCCCAAGACAGCCTCCAGC
TCAGTGAGGACGAAGCCCCTTACCATCAGGCCACTCCCGATCATGGTTATCTGAGTTTGCTGTATGACTCTCCCAGTGGTAACTTGTCTA
TGCCTCATAAGCCTGTATCTGATAAACTGTCCGAAGAAGTAGATGAAATCTGGAATGACCTGGAAAATTACATCAAGAAAAATGAAGACA
AGGCCAGAGACCGTCTCCTGGCAGCGTTTCCTGTGAGCAAGGATGATGTGCCAGACAGGCTGCACGCAGAGAGCACCCCTGAGCTGAGCC
GGGACGTGGGGCGCTCTGTGTCCACGCTGTCCCTGCCTGAGAGCCAGGCTCTCCTCACGCCCGTGAAGAGCAGGGCTGGCAGAGCCAGCC
GCGCCAACTGCCCCTTTGAGGAAGACCTGATTTCTAAAGAAGGCTCCTTTATGAGCCTTAACCGGCTTTCTCTGGCTAGTGAAATGCCCC
TCATGGACAATCCCTACGACCTGGCCAACAGTGGCCTGTCTCAAACAGACCCAGAAAACCCTGACCTGGGGATGGAGGCCACAGATAAGA
CAAAAAGCAGGGTGTTTATGATGGCTCGGCAGTACAGTCAGAAGATTAAGAAGGCGAATCAACTTTTAAAAGTGAAAAGTCTGGAGCTGG
AGCAGCCGCCGGCCAGTCAGCATCAGAAATCCATGCACAAAGACCTGGCTGCCATCTTGGAAGAGAAGAAGCAAGGAGGGCCCGCCATTG
GTGCCAGGATTGCTGAGTATTCCCAGTTGTATGACCAGATTGTATTCAGAGAGTCTCCCTTGAAAATTCAGAAGGATGGCTGGGCCAGCC
CTCAAGAATCCTCCCTCCTGAGGTCTGTGTCACCTTCCCAGGTCCACCATGGTAGTGGAGACTGGCTTCTGCATTCAACCTATAGTAATG
GAGAGTTAGCAGATTTCTGTCTCCCACCAGAGCAAGACTTGAGGTCAAGATATCCCACGTTTGAGATCAATACAAAAAGTACTCCCAGGC
AATTGTCCGCAGCTTGCTCTGTGCCTTCTCTTCAAACCTCTGACCCTCTGCCAGGCTCTGTGCAGAGATGCAGCGTGGTAGTAAGTCAGC
CCAACAAAGAGAACTGGTGTCAGGACCATCTTTACAACTCCTTGGGTCGGAAAGGGATCAGCGCTAAATCTCAGCCTTATCACAGGTCCC
AGTCATCTTCCTCCGTCTTGATCAACAAATCAATGGATTCCATCAACTACCCTAGTGATGTGGGAAAGCAGCAGCTGCTGTCTTTACACA
GAAGTTCAAGGTGTGAGAGTCACCAGGACTTGCTGCCAGATATTGCTGACTCGCATCAACAGGGCACTGAAAAACTCTCAGATCTCACAC
TCCAAGACTCACAGAAAGTTGTGGTGGTCAATAGAAATTTACCCTTAAATGCCCAAATTGCAACACAGAATTATTTTTCCAATTTCAAAG
AGACTGATGGAGATGAAGATGACTATGTGGAAATCAAGTCAGAAGAAGATGAGTCGGAGTTGGAGCTATCTCACAATCGTAGAAGGAAAT
CTGACTCAAAGTTTGTGGATGCTGACTTTTCTGATAATGTCTGCAGCGGCAACACATTGCATTCTTTGAATAGTCCGCGCACTCCAAAAA
AGCCGGTTAACAGCAAACTTGGCCTTTCACCATATCTGACACCATATAATGATTCTGACAAACTGAATGACTATCTTTGGAGGGGGCCAT
CTCCCAATCAACAAAATATTGTCCAGTCTCTAAGGGAAAAATTTCAGTGTCTCAGTTCAAGCAGCTTTGCTTAAGGTTCTTCATAATAAC
TGCTTGAATCAACTTCTTATTTTGCTCATAAAACGTTACAGATACTGATGAGGTGTTTTATGTATACCAGATTAAAACAATTTTGTAAGA
ACCAGAGGTGTAAAATATACTTTCTTTTACAGCACAACTTTTGGAAATGGCTGACGATGCAGCCCGGATTGTACTGTAGCACATGTTGGC
ATCAACAGTATATTTTCTCATGCTGAGTGTCTTCATGTTTCATGTAAGTCAATCTTACTTGAAAGTTTTTAGACTTTTAACACGATGGCC
ATAACCTGACAATAGTGCCCACACCTTAAGAAATGCAATAATCCTTTCCTGTTATCCAGAAGGCCCAGGTAGTTTTATCCTGTGACTCAA
AGGCAGCAAGGAGACTTTTTCACATTTTAAAAGGCAACGAAAGCTGTTGAAAGAATTATGCTTATATCTCACATTTTGGTTATATTTGTG
GTAACACCTTAGGATAACGTAAGCCAGAGATCTGTAAATTGGACTGCAGTCTGAGGTGCCCATTTTAGGGTTTTTGTGCTAGTATTCTTT
TATGTCATTTTGATGCAGAAATTGTGTGACTGTTGAAAATTAAAATGTAGCGGGACCCATTTTCTGTACGCAGAACCCTTTACCTGTATT
CCTGGACAAGGCCTAGAGAACGAGCTGCTCATCATGTTTCTAATATAATTTCTGGGGTGAAATGAATGATTTCCTTACTGGCTTAGAGAA
AACCAAGGTCAATAAAATGCAGATTGACTTAACTATTAGAAAAGATGGGATGACTTCTGGGAACCACTTAACTCTTCAAATGACTGTTGA
AAGAGAAAAAGCAAAACTGAAATCCCACCAGACCATTTTGTGTGCCTGTTTCTAATCGATACAAAGTTAAGCATGAGCTAAAATCAGACA
AAGCACTTTAAATTTATCCTTTCCAGAGCGCTTTGCACATGCACCCTCCTGAGTTTGGGATTCTGCCAAATGACCAACTTGATCCTGGCC
CTGAGGAGTCATTGGCTGCAGGAATAGGGCAAGAATCTATTTCCTAAACTACACATAACATGGGAGCCTTTTTTTCGTTGTTTTCAGGTA
TATTAAAGAATGAAATCTTTGGTTACTAGGTGCTGACTAATAAATAACACCTTTTATATTCTGACCATTTGTCACATTTCATTGTGATAC
TGTATACTGATCTAACTCCTTATGAAAGGCAACAAACAAAAATAAGACATTGAATAAAAAGCAAAATCAAAGAAGCTAAAGAGAAAAATG
AAGGCAGATATATTGCAACTTTATAACATATTCTATTTTATTGAAGACTGCAATTAATGCAGCAAGAATGCTTTCTCAAGCGGTGGCCTT
TGTATTCTCATTTTAATCAGGTGTACATTCTATGGCCTCTCCCCCATGCTGTTAGTTTCTATTTTAAAAGATACAATAATATATGTAGGG
AAAGGGGCCTGGGCTCTTCATTTAAAGGTAAGCAGTAATATTGAGTAAGTGACATAATTCTTTTTCTCTTTGTTAAGTCCTATGCCTCTT
TTTCTTAACTGTAAAACATAGAATATGAGCGTTTTTATCTTACAAATAGGTACCTAAGGCATGTGATTTTATTTTTAAATAACAAAAAAT
AACCCAAGTTTCTTGCTTCTCCAAAGTATTCTTCTCATAGCTTATAAAAGAAAGTCCACATTGAATAGCATGGTCTGGGAACATTCCTTC
TTTATTGTGTTTATTTGAACATGATATGAGTTTCCAAGATGAAATGATCAAAAAAGATAAGTACCACAAGAAAGTTTTTTTGTTTGGTTG
GTTTTTTTGTTTGTTTGTTTTTTTCTTGAGACTGAGTCTCTCCCTGTTGCCCAAGTTGGAGTGCAATCTTGGCTCACTGCAGCCTCCACC
TCCCCGGTTCCAGCGATTCTCCTGCCTCAGCCTCTTGAATAGCTGGGATTACAGGCGCCCGCCACCACACCTGGCTAATTTTTGTGTTGT
TAGTAGAGGCGGGGTTTCATCATGTTGGCCAGGCTGGTCTCGAACTCCTGATCTCATGATCCGTCTGCCTCGGCCTCCCAGAGTGCTGGG
ATTACAGGCATGAGCCACTGCGCCCGGCCAAGAAAGTATGTTTTTAGAGGTGTGTGTAAGTGCATTTGTATTACCTATGAACAAAATTAC
CTGACTCTTGTCCCAGGAAAGCTGTTTCGCATTTTCGCTTTTTGATTGGTATTATCCAGTTCTATGTAGTTCATATTATTGTTCTGTCTG
ACTCTCAGAAATTACTTCTTCACGCCAGTGTCTTGTTGCATGACTTTGATGTCACCTATAGGAATACACCTCACTGCACGTAAGTGGGTA
TCTTACTGTATAAAAGGTCTACATGGCTTTAGGTTTTAGGACAAATGTGTAGATTTATAGACCATTTCTGTTGGCCAGGACACAGATTTT
GAGAGCTGTGTGTATATATATATAATCATGTTTGTATTTTTTTCCTGAAAGTTATCAATTGCTTTTGTTTAAAACAGTTTGTTTTAGAGG
TGGGGTGGGGATGTATATAACGAGGAAAAGTTATATGTACTTTAAAGTATGTCAAGTTCTTACTAGTTTCCTGTACTGAAGGTTCAATTT
TTTTTATATAAGTTTACTTTTCACCTGCTCTATTCTTTGTGGGGAAAAAATGCATCTAGAAAAACATAGTTTAAATACTGTATATAAGAT

>In-frame_ENST00000398571_ENST00000358517_TCGA-25-2401-01A_USP34_chr2_61647881_-_PLEKHG1_chr6_151107526_length(amino acids)=1258AA_start in transcript=77_stop in transcript=3853
MCENCADLVEVLNEISDVEGGDGLQLRKEHTLKIFTYINSWTQSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTE
CMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQ
SLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQ
AKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLKTSETAQD
IQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLC
EDSTSSRPCSWHMGQMESTETSSSGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHVYDNISYE
DLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGTLSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKC
SSLKRAKRSTFLGLEADFVCCDSLRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWNDLENYIK
KNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALLTPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLA
SEMPLMDNPYDLANSGLSQTDPENPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAILEEKKQG
GPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGSGDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTK
STPRQLSAACSVPSLQTSDPLPGSVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPSDVGKQQL
LSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQIATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHN

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Fusion Gene PPI Analysis for USP34-PLEKHG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP34-PLEKHG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP34-PLEKHG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSP34C0004238Atrial Fibrillation1CTD_human
HgeneUSP34C0235480Paroxysmal atrial fibrillation1CTD_human
HgeneUSP34C2585653Persistent atrial fibrillation1CTD_human
HgeneUSP34C3468561familial atrial fibrillation1CTD_human
TgenePLEKHG1C0028043Nicotine Dependence1CTD_human
TgenePLEKHG1C0040332Tobacco Dependence1CTD_human
TgenePLEKHG1C0376384Nicotine Use Disorder1CTD_human