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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP34-XPO1 (FusionGDB2 ID:96763)

Fusion Gene Summary for USP34-XPO1

check button Fusion gene summary
Fusion gene informationFusion gene name: USP34-XPO1
Fusion gene ID: 96763
HgeneTgene
Gene symbol

USP34

XPO1

Gene ID

9736

7514

Gene nameubiquitin specific peptidase 34exportin 1
Synonyms-CRM-1|CRM1|emb|exp1
Cytomap

2p15

2p15

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34exportin-1chromosome region maintenance 1 homologchromosome region maintenance 1 protein homologexportin 1 (CRM1 homolog, yeast)exportin-1 (required for chromosome region maintenance)
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000398571, ENST00000472689, 
ENST00000401558, ENST00000404992, 
ENST00000406957, ENST00000481214, 
Fusion gene scores* DoF score30 X 29 X 14=1218012 X 13 X 4=624
# samples 3717
** MAII scorelog2(37/12180*10)=-5.04084505227738
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/624*10)=-1.87601128272455
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP34 [Title/Abstract] AND XPO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP34(61597455)-XPO1(61761038), # samples:1
USP34(61632843)-XPO1(61711240), # samples:1
USP34(61697785)-XPO1(61729445), # samples:1
XPO1(61753554)-USP34(61434021), # samples:1
XPO1(61749746)-USP34(61448741), # samples:1
XPO1(61749746)-USP34(61449798), # samples:1
XPO1(61749746)-USP34(61647968), # samples:1
XPO1(61749746)-USP34(61528589), # samples:1
Anticipated loss of major functional domain due to fusion event.XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
XPO1-USP34 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
XPO1-USP34 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
USP34-XPO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
USP34-XPO1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
USP34-XPO1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
USP34-XPO1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
USP34-XPO1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP34

GO:0016579

protein deubiquitination

14715245

HgeneUSP34

GO:0071108

protein K48-linked deubiquitination

21383061

HgeneUSP34

GO:0090263

positive regulation of canonical Wnt signaling pathway

21383061

TgeneXPO1

GO:0006611

protein export from nucleus

22250199


check buttonFusion gene breakpoints across USP34 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across XPO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A97HUSP34chr2

61597455

-XPO1chr2

61761038

-
ChimerDB4STADTCGA-HU-A4GN-01AUSP34chr2

61632843

-XPO1chr2

61711240

-
ChimerDB4STADTCGA-BR-A4PD-01AUSP34chr2

61697785

-XPO1chr2

61729445

-


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Fusion Gene ORF analysis for USP34-XPO1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000398571ENST00000401558USP34chr2

61597455

-XPO1chr2

61761038

-
5CDS-5UTRENST00000398571ENST00000404992USP34chr2

61597455

-XPO1chr2

61761038

-
5CDS-5UTRENST00000398571ENST00000406957USP34chr2

61597455

-XPO1chr2

61761038

-
5CDS-5UTRENST00000398571ENST00000481214USP34chr2

61597455

-XPO1chr2

61761038

-
intron-5UTRENST00000472689ENST00000401558USP34chr2

61597455

-XPO1chr2

61761038

-
intron-5UTRENST00000472689ENST00000404992USP34chr2

61597455

-XPO1chr2

61761038

-
intron-5UTRENST00000472689ENST00000406957USP34chr2

61597455

-XPO1chr2

61761038

-
intron-5UTRENST00000472689ENST00000481214USP34chr2

61597455

-XPO1chr2

61761038

-
In-frameENST00000398571ENST00000401558USP34chr2

61632843

-XPO1chr2

61711240

-
In-frameENST00000398571ENST00000404992USP34chr2

61632843

-XPO1chr2

61711240

-
In-frameENST00000398571ENST00000406957USP34chr2

61632843

-XPO1chr2

61711240

-
5CDS-intronENST00000398571ENST00000481214USP34chr2

61632843

-XPO1chr2

61711240

-
intron-3CDSENST00000472689ENST00000401558USP34chr2

61632843

-XPO1chr2

61711240

-
intron-3CDSENST00000472689ENST00000404992USP34chr2

61632843

-XPO1chr2

61711240

-
intron-3CDSENST00000472689ENST00000406957USP34chr2

61632843

-XPO1chr2

61711240

-
intron-intronENST00000472689ENST00000481214USP34chr2

61632843

-XPO1chr2

61711240

-
Frame-shiftENST00000398571ENST00000401558USP34chr2

61697785

-XPO1chr2

61729445

-
Frame-shiftENST00000398571ENST00000404992USP34chr2

61697785

-XPO1chr2

61729445

-
Frame-shiftENST00000398571ENST00000406957USP34chr2

61697785

-XPO1chr2

61729445

-
5CDS-intronENST00000398571ENST00000481214USP34chr2

61697785

-XPO1chr2

61729445

-
intron-3CDSENST00000472689ENST00000401558USP34chr2

61697785

-XPO1chr2

61729445

-
intron-3CDSENST00000472689ENST00000404992USP34chr2

61697785

-XPO1chr2

61729445

-
intron-3CDSENST00000472689ENST00000406957USP34chr2

61697785

-XPO1chr2

61729445

-
intron-intronENST00000472689ENST00000481214USP34chr2

61697785

-XPO1chr2

61729445

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for USP34-XPO1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP34-XPO1


check button Go to

FGviewer for the breakpoints of chr2:61632843-chr2:61711240

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneXPO1chr2:61632843chr2:61711240ENST0000040155819251002_1039836.01072.0RepeatNote=HEAT 10
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925885_916836.01072.0RepeatNote=HEAT 8
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925917_954836.01072.0RepeatNote=HEAT 9
TgeneXPO1chr2:61632843chr2:61711240ENST0000040499219251002_1039836.01072.0RepeatNote=HEAT 10
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925885_916836.01072.0RepeatNote=HEAT 8
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925917_954836.01072.0RepeatNote=HEAT 9
TgeneXPO1chr2:61632843chr2:61711240ENST0000040695720261002_1039836.01072.0RepeatNote=HEAT 10
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026885_916836.01072.0RepeatNote=HEAT 8
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026917_954836.01072.0RepeatNote=HEAT 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP34chr2:61632843chr2:61711240ENST00000398571-3801894_2239184.03547.0DomainNote=USP
TgeneXPO1chr2:61632843chr2:61711240ENST00000401558192546_112836.01072.0DomainImportin N-terminal
TgeneXPO1chr2:61632843chr2:61711240ENST00000404992192546_112836.01072.0DomainImportin N-terminal
TgeneXPO1chr2:61632843chr2:61711240ENST00000406957202646_112836.01072.0DomainImportin N-terminal
TgeneXPO1chr2:61632843chr2:61711240ENST0000040155819251_679836.01072.0RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925411_414836.01072.0RegionNote=Necessary for HTLV-1 Rex multimerization
TgeneXPO1chr2:61632843chr2:61711240ENST0000040499219251_679836.01072.0RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925411_414836.01072.0RegionNote=Necessary for HTLV-1 Rex multimerization
TgeneXPO1chr2:61632843chr2:61711240ENST0000040695720261_679836.01072.0RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026411_414836.01072.0RegionNote=Necessary for HTLV-1 Rex multimerization
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925217_240836.01072.0RepeatNote=HEAT 1
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925241_277836.01072.0RepeatNote=HEAT 2
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925354_472836.01072.0RepeatNote=HEAT 3
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925515_553836.01072.0RepeatNote=HEAT 4
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925560_597836.01072.0RepeatNote=HEAT 5
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925602_639836.01072.0RepeatNote=HEAT 6
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925775_813836.01072.0RepeatNote=HEAT 7
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925217_240836.01072.0RepeatNote=HEAT 1
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925241_277836.01072.0RepeatNote=HEAT 2
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925354_472836.01072.0RepeatNote=HEAT 3
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925515_553836.01072.0RepeatNote=HEAT 4
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925560_597836.01072.0RepeatNote=HEAT 5
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925602_639836.01072.0RepeatNote=HEAT 6
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925775_813836.01072.0RepeatNote=HEAT 7
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026217_240836.01072.0RepeatNote=HEAT 1
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026241_277836.01072.0RepeatNote=HEAT 2
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026354_472836.01072.0RepeatNote=HEAT 3
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026515_553836.01072.0RepeatNote=HEAT 4
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026560_597836.01072.0RepeatNote=HEAT 5
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026602_639836.01072.0RepeatNote=HEAT 6
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026775_813836.01072.0RepeatNote=HEAT 7


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Fusion Gene Sequence for USP34-XPO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for USP34-XPO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925800_820836.01072.0HIV-1 Rev
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925800_820836.01072.0HIV-1 Rev
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026800_820836.01072.0HIV-1 Rev
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925327_450836.01072.0Ran and nuclear export complex formation
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925327_450836.01072.0Ran and nuclear export complex formation
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026327_450836.01072.0Ran and nuclear export complex formation
TgeneXPO1chr2:61632843chr2:61711240ENST000004015581925411_481836.01072.0RANBP3
TgeneXPO1chr2:61632843chr2:61711240ENST000004049921925411_481836.01072.0RANBP3
TgeneXPO1chr2:61632843chr2:61711240ENST000004069572026411_481836.01072.0RANBP3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP34-XPO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP34-XPO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSP34C0004238Atrial Fibrillation1CTD_human
HgeneUSP34C0235480Paroxysmal atrial fibrillation1CTD_human
HgeneUSP34C2585653Persistent atrial fibrillation1CTD_human
HgeneUSP34C3468561familial atrial fibrillation1CTD_human
TgeneXPO1C0004238Atrial Fibrillation1CTD_human
TgeneXPO1C0033578Prostatic Neoplasms1CTD_human
TgeneXPO1C0235480Paroxysmal atrial fibrillation1CTD_human
TgeneXPO1C0376358Malignant neoplasm of prostate1CTD_human
TgeneXPO1C1292754Mediastinal (Thymic) Large B-Cell Lymphoma1ORPHANET
TgeneXPO1C2585653Persistent atrial fibrillation1CTD_human
TgeneXPO1C3468561familial atrial fibrillation1CTD_human