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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP37-EDEM3 (FusionGDB2 ID:96783)

Fusion Gene Summary for USP37-EDEM3

check button Fusion gene summary
Fusion gene informationFusion gene name: USP37-EDEM3
Fusion gene ID: 96783
HgeneTgene
Gene symbol

USP37

EDEM3

Gene ID

57695

80267

Gene nameubiquitin specific peptidase 37ER degradation enhancing alpha-mannosidase like protein 3
Synonyms-C1orf22
Cytomap

2q35

1q25.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 37deubiquitinating enzyme 37tmp_locus_50ubiquitin specific protease 37ubiquitin thioesterase 37ubiquitin thiolesterase 37ubiquitin-specific-processing protease 37ER degradation-enhancing alpha-mannosidase-like protein 3ER degradation enhancer, mannosidase alpha-like 3ER degradation-enhancing -mannosidase-like protein 3ER degradation-enhancing alpha-mannosidase-like 3alpha-1,2-mannosidase EDEM3
Modification date2020031320200313
UniProtAcc.

Q9BZQ6

Ensembl transtripts involved in fusion geneENST00000258399, ENST00000454775, 
ENST00000415516, ENST00000418019, 
ENST00000338465, ENST00000475553, 
ENST00000318130, ENST00000367512, 
ENST00000466392, 
Fusion gene scores* DoF score10 X 9 X 7=6306 X 6 X 3=108
# samples 116
** MAII scorelog2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP37 [Title/Abstract] AND EDEM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP37(219418276)-EDEM3(184681011), # samples:1
Anticipated loss of major functional domain due to fusion event.USP37-EDEM3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
USP37-EDEM3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP37

GO:0000082

G1/S transition of mitotic cell cycle

21596315

HgeneUSP37

GO:0016579

protein deubiquitination

14715245

HgeneUSP37

GO:0035871

protein K11-linked deubiquitination

21596315

HgeneUSP37

GO:0071108

protein K48-linked deubiquitination

21596315


check buttonFusion gene breakpoints across USP37 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EDEM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315469USP37chr2

219418276

-EDEM3chr1

184681011

-


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Fusion Gene ORF analysis for USP37-EDEM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000258399ENST00000318130USP37chr2

219418276

-EDEM3chr1

184681011

-
In-frameENST00000258399ENST00000367512USP37chr2

219418276

-EDEM3chr1

184681011

-
5CDS-intronENST00000258399ENST00000466392USP37chr2

219418276

-EDEM3chr1

184681011

-
Frame-shiftENST00000454775ENST00000318130USP37chr2

219418276

-EDEM3chr1

184681011

-
Frame-shiftENST00000454775ENST00000367512USP37chr2

219418276

-EDEM3chr1

184681011

-
5CDS-intronENST00000454775ENST00000466392USP37chr2

219418276

-EDEM3chr1

184681011

-
In-frameENST00000415516ENST00000318130USP37chr2

219418276

-EDEM3chr1

184681011

-
In-frameENST00000415516ENST00000367512USP37chr2

219418276

-EDEM3chr1

184681011

-
5CDS-intronENST00000415516ENST00000466392USP37chr2

219418276

-EDEM3chr1

184681011

-
In-frameENST00000418019ENST00000318130USP37chr2

219418276

-EDEM3chr1

184681011

-
In-frameENST00000418019ENST00000367512USP37chr2

219418276

-EDEM3chr1

184681011

-
5CDS-intronENST00000418019ENST00000466392USP37chr2

219418276

-EDEM3chr1

184681011

-
In-frameENST00000338465ENST00000318130USP37chr2

219418276

-EDEM3chr1

184681011

-
In-frameENST00000338465ENST00000367512USP37chr2

219418276

-EDEM3chr1

184681011

-
5CDS-intronENST00000338465ENST00000466392USP37chr2

219418276

-EDEM3chr1

184681011

-
intron-3CDSENST00000475553ENST00000318130USP37chr2

219418276

-EDEM3chr1

184681011

-
intron-3CDSENST00000475553ENST00000367512USP37chr2

219418276

-EDEM3chr1

184681011

-
intron-intronENST00000475553ENST00000466392USP37chr2

219418276

-EDEM3chr1

184681011

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000258399USP37chr2219418276-ENST00000318130EDEM3chr1184681011-58367417112003430
ENST00000258399USP37chr2219418276-ENST00000367512EDEM3chr1184681011-22927417112051446
ENST00000415516USP37chr2219418276-ENST00000318130EDEM3chr1184681011-56365415111803430
ENST00000415516USP37chr2219418276-ENST00000367512EDEM3chr1184681011-20925415111851446
ENST00000418019USP37chr2219418276-ENST00000318130EDEM3chr1184681011-57216265961888430
ENST00000418019USP37chr2219418276-ENST00000367512EDEM3chr1184681011-21776265961936446
ENST00000338465USP37chr2219418276-ENST00000318130EDEM3chr1184681011-58017066761968430
ENST00000338465USP37chr2219418276-ENST00000367512EDEM3chr1184681011-22577066762016446

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258399ENST00000318130USP37chr2219418276-EDEM3chr1184681011-0.0002370110.99976295
ENST00000258399ENST00000367512USP37chr2219418276-EDEM3chr1184681011-0.0012280550.99877197
ENST00000415516ENST00000318130USP37chr2219418276-EDEM3chr1184681011-0.0002339540.99976605
ENST00000415516ENST00000367512USP37chr2219418276-EDEM3chr1184681011-0.0012511320.9987489
ENST00000418019ENST00000318130USP37chr2219418276-EDEM3chr1184681011-0.0002442030.9997558
ENST00000418019ENST00000367512USP37chr2219418276-EDEM3chr1184681011-0.001358880.9986411
ENST00000338465ENST00000318130USP37chr2219418276-EDEM3chr1184681011-0.0002457580.99975425
ENST00000338465ENST00000367512USP37chr2219418276-EDEM3chr1184681011-0.0014198470.9985802

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Fusion Genomic Features for USP37-EDEM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP37-EDEM3


check button Go to

FGviewer for the breakpoints of chr2:219418276-chr1:184681011

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EDEM3

Q9BZQ6

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:25092655}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP37chr2:219418276chr1:184681011ENST00000258399-52671_79109.33333333333333980.0MotifNote=D-box 1
HgeneUSP37chr2:219418276chr1:184681011ENST00000258399-52696_105109.33333333333333980.0MotifNote=D-box 2
HgeneUSP37chr2:219418276chr1:184681011ENST00000418019-52671_79109.33333333333333980.0MotifNote=D-box 1
HgeneUSP37chr2:219418276chr1:184681011ENST00000418019-52696_105109.33333333333333980.0MotifNote=D-box 2
HgeneUSP37chr2:219418276chr1:184681011ENST00000454775-52671_79109.33333333333333980.0MotifNote=D-box 1
HgeneUSP37chr2:219418276chr1:184681011ENST00000454775-52696_105109.33333333333333980.0MotifNote=D-box 2
TgeneEDEM3chr2:219418276chr1:184681011ENST000003181301320674_779512.0933.0DomainNote=PA
TgeneEDEM3chr2:219418276chr1:184681011ENST000003181301320929_932512.0933.0MotifPrevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP37chr2:219418276chr1:184681011ENST00000258399-526341_951109.33333333333333980.0DomainNote=USP
HgeneUSP37chr2:219418276chr1:184681011ENST00000258399-526704_723109.33333333333333980.0DomainUIM 1
HgeneUSP37chr2:219418276chr1:184681011ENST00000258399-526806_825109.33333333333333980.0DomainUIM 2
HgeneUSP37chr2:219418276chr1:184681011ENST00000258399-526828_847109.33333333333333980.0DomainUIM 3
HgeneUSP37chr2:219418276chr1:184681011ENST00000415516-424341_95137.333333333333336886.0DomainNote=USP
HgeneUSP37chr2:219418276chr1:184681011ENST00000415516-424704_72337.333333333333336886.0DomainUIM 1
HgeneUSP37chr2:219418276chr1:184681011ENST00000415516-424806_82537.333333333333336886.0DomainUIM 2
HgeneUSP37chr2:219418276chr1:184681011ENST00000415516-424828_84737.333333333333336886.0DomainUIM 3
HgeneUSP37chr2:219418276chr1:184681011ENST00000418019-526341_951109.33333333333333980.0DomainNote=USP
HgeneUSP37chr2:219418276chr1:184681011ENST00000418019-526704_723109.33333333333333980.0DomainUIM 1
HgeneUSP37chr2:219418276chr1:184681011ENST00000418019-526806_825109.33333333333333980.0DomainUIM 2
HgeneUSP37chr2:219418276chr1:184681011ENST00000418019-526828_847109.33333333333333980.0DomainUIM 3
HgeneUSP37chr2:219418276chr1:184681011ENST00000454775-526341_951109.33333333333333980.0DomainNote=USP
HgeneUSP37chr2:219418276chr1:184681011ENST00000454775-526704_723109.33333333333333980.0DomainUIM 1
HgeneUSP37chr2:219418276chr1:184681011ENST00000454775-526806_825109.33333333333333980.0DomainUIM 2
HgeneUSP37chr2:219418276chr1:184681011ENST00000454775-526828_847109.33333333333333980.0DomainUIM 3
HgeneUSP37chr2:219418276chr1:184681011ENST00000258399-526160_168109.33333333333333980.0MotifNote=D-box 3
HgeneUSP37chr2:219418276chr1:184681011ENST00000415516-424160_16837.333333333333336886.0MotifNote=D-box 3
HgeneUSP37chr2:219418276chr1:184681011ENST00000415516-42471_7937.333333333333336886.0MotifNote=D-box 1
HgeneUSP37chr2:219418276chr1:184681011ENST00000415516-42496_10537.333333333333336886.0MotifNote=D-box 2
HgeneUSP37chr2:219418276chr1:184681011ENST00000418019-526160_168109.33333333333333980.0MotifNote=D-box 3
HgeneUSP37chr2:219418276chr1:184681011ENST00000454775-526160_168109.33333333333333980.0MotifNote=D-box 3


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Fusion Gene Sequence for USP37-EDEM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000258399_ENST00000318130_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(transcript)=5836nt_BP=741nt
GTGCGTGCGTGTTTGCGTGTGGTCACAGTTCCCGCCATCAGCCGCTCTCCCTGACTAGGGGTAGCTAGCGGCCTCCCTCCTTTGGGTTCG
GTATCCCTACTTCCATTACCCTCGGCTCCTCCCACTCCTCGCGGGCTCCGTGCTTTCCGCGGGTCTGTCCGGGGGCTCCGGACCCTCGGC
GCAGCTGAGTTGATGGCTTCCGGAGAACTGGCATAGCTGCAGAATATGAGTAGTGTCCCAAGAAGAGTGCTTTGCCTTTGGCACAAGGAT
CAGAATAAAGGTGAATTGCTATTACATAGGGTTTTTCGGTAAAAGTCACTGAAAATTATTTGCCATACAGTAACCAGAGACCTCCAACTA
GGGGCCCCCAAACTGTATCCTGCCTGTAGCCAGAAGCAATTTTTAAAGAAAATATGTCTCCTCTGAAGATACATGGTCCTATCAGAATTC
GAAGTATGCAGACTGGGATTACAAAGTGGAAAGAAGGATCCTTTGAAATTGTAGAAAAAGAGAATAAAGTCAGCCTAGTAGTTCACTACA
ATACTGGAGGAATTCCAAGGATATTTCAGCTAAGTCATAACATTAAAAATGTGGTGCTTCGACCCAGTGGAGCGAAACAAAGCCGCCTAA
TGTTAACTCTGCAAGATAACAGCTTCTTGTCTATTGACAAAGTACCAAGTAAGGATGCAGAGGAAATGAGGTTGTTTCTAGATGCAGTCC
ATCAAAACAGACTTCCTGCAGACCTCGGAATATACAGAACTGGATGACAGTAACTTCGATTGGACTTGTCCAAATACTCAGATCCTCTTT
CCTAATGACCCATTGTATGCTCAAAGTATTCGTGAGCCCTTGAAAAATGTGGTGGATAAGAGCTGTCCTAGAGGCATCATCAGAGTAGAG
GAGAGTTTCAGGAGTGGAGCTAAACCCCCTCTGAGAGCCAGAGATTTCATGGCCACTAACCCTGAGCATTTAGAAATCCTGAAGAAGATG
GGGGTGAGTTTGATTCACCTCAAAGATGGGAGAGTCCAGTTGGTCCAACATGCAATCCAAGCTGCTAGTTCAATCGACGCTGAAGATGGG
TTGAGGTTCATGCAGGAGATGATTGAATTGTCAAGTCAGCAACAAAAAGAACAGCAGCTGCCTCCACGAGCTGTACAAATTGTTTCCCAC
CCATTTTTTGGCAGGGTAGTATTGACTGCTGGACCAGCTCAGTTTGGGCTGGATCTGTCTAAACATAAAGAGACAAGAGGATTTGTTGCA
AGCAGTAAACCATCCAATGGTTGTTCAGAGCTTACTAACCCAGAGGCAGTGATGGGAAAAATCGCACTGATACAAAGAGGACAGTGCATG
TTTGCAGAAAAGGCACGCAACATCCAGAATGCTGGAGCCATTGGTGGCATTGTTATTGATGACAATGAGGGGAGCAGCAGTGATACTGCC
CCTCTGTTCCAGATGGCAGGTGATGGAAAGGATACAGATGACATCAAGATCCCCATGCTGTTCTTATTCAGCAAAGAAGGAAGTATCATA
CTGGATGCCATCCGGGAATATGAGGAGGTAGAAGTGCTCCTCTCTGATAAAGCAAAAGATCGAGATCCTGAAATGGAAAATGAAGAACAA
CCATCCTCTGAAAATGATTCTCAGAATCAGAGTGGTGAACAGATTTCATCAAGTTCTCAGGAGGTTGATTTGGTTGATCAAGAGTCTTCT
GAGGAAAATTCTCTAAATTCTCACCCAGAATCATTATCTCTAGCAGATATGGACAATGCTGCAAGCATTTCCCCTTCTGAACAGACTTCT
AATCCCACAGAAAACCATGAGACTACAAATCTTAATGGTGAATGTACAGATTTAGATAACCAGCTTCAAGAACAATCAGAAACTGAGGAA
GATTCCAATCCTAATGTTAGCTGGGGTAAAAAGGTCCAGCCTATAGACTCCATATTAGCAGACTGGAATGAAGATATAGAAGCATTTGAA
ATGATGGAGAAGGATGAGCTATGACTTGCTAAACAATCTGTTGGTAGGTATTTAAAAAGAAAAGGTAAACTGTGTGTGGTTAATAGACAT
CCTAATACTAAGCAGGCTTTCTAATGGGAGGCTTTAAGTATGGTGATGAACAACCACGTTCTGACTGGCGTAGTTATCGTAGGAATCTGG
AGCATGCTGTGTTAGAATTGACCTTGTTTAAAACTGTCCCATCAAAAATGGAAATCCACAGTTCCCCCTTCAAATGCAGCACTGCACCAC
CCTGCAACACCTCAGGCCAGGGAAAGATTACTGAGCATTCCTGCGAACCAGATTTCTGTTGTCTCTGGATAGACAAGAAACAAAATTCAT
TTAGTAGTGGAGTGGGGAATAGGAGTTTGGATAGCCTTCTAATTAAAGGAAGCTCGCCTTTCTTGGTTTTGGGGGTTAGAGGCTCTTTTG
GGAAGATGCATCCGAGTATTGTGGCATTCTGATTATGCTGCCTTCACAAAACACTCTAAGTGACCTAAGTGGTTATGAAGCAAATGCATT
TATGGTGAAAACAGTCTTTGCTCATTGCTTTCTCTTGTTTCATTTAGTGACAAATGATCAAGATGACTTGATTTTTTTTCCTTCTTAACA
ATGTCTTTTTTATTTAAACCAAAGGTGAAGCCAGTGTACTTTCTCAGTGAGTTCTCTGCATAAAGACTAATCAGTGGGACCAGGTAAAAA
GGTCATATAATACATTGTGGAGATTGCTTACTTAATACTTCTGAAAAATGGAGTAAGGGAGAAACTGTAATGTTGCAATATGAACCTCCC
ATTGGGCCTTCCATAGGGAAAGCTGTGACTACTCTGAAATGGAACCTAGCATTATATCCTTGTAGGGTAGATTATAAATCATTTCCAGTT
CATTTCTCTTAGAGGTGATTACCTCTAGCCATCAGCCTTACTCCATCCCATGTTTGGTATGCAATTTGAGCCACAAGGCTCGTATCGCCA
ACAGCTATATACATTTTGTTCCATTTTTCTGTCTTACAGAGCCATGATAGAACTGTGGTTAGTGAGTTAAAATTCCTGGAGTAACTACTG
TTTTTCTCCTTTGAAACTTAGGTTTCTAAAGTTGCACCTAAGGAATCTGTCACATTTTCTGTTGAATCATGGTTTTTGTTTTTGTTTTTA
ACAGATATTCCTTCTGATACGGACTTGAAAATTAGTGTATGGTGACCTGTGTTTAAAAAAAAAAGTACAATACAACTACATATAGCTATA
TAGCTTAATGAGACTTCCACCCCCCCCCTTTTTTTTTTTGGTTTGTTGTTGTTGTAGTAGTCTGGTGCTGGCCACATTTAAGTCTTAAAA
ATTTTTAAATTTTGTTGTTGATGTTTGTAGACAGCCCTGTTGTTGAAATCATGGCTTTATTCATTTTATTTATTTTTTAAACTTGCCTGA
ATTTGTTCTAAAGGAATATTTAAGAGACATAATTTTCTTCTCTTTACCATAACATTACACAAAACTTTTTCCTAAAACACGGTTGTGAGG
TACTGATGAGGTGTAAGTGGAGCTGTTAAAAACAGCAGTGCTGTATTGCAGTTATGTATATTCGTGTACAGTATGTTTAGATCCCAGGTA
AACATATTCTTTTCTGAGAGGATAAATACCTGCATTCAGATATTCCAGGTAAATATAATTGAGTCAGGGAGTAGTAAATCTGATGGAGAA
TTCACTTTGGGGAGGGGAAAAAGAATAGTATGCAAGACCCTTATTGGCTTTTAATTATACCTGAAACCAAAATGGATATTTTTAGTCTCT
CTGCATGTGAGATTTGGTGTAACAAGATAGAACTATAATATATACAGTATATGGAAGGATAGATATAGTGCTTTGTTCATTTTAATTGCA
AAGCTGCCAAAATAGTTGAAGCTTAATTACTTGACTTGCCTTGATTTATAGGACTGGGGCTTGGAGAAAATGAGCAGATGTTCCTCTAAG
ACATCGATTACAGAAGCCTTATATACATGGATTTGATTTTGTATTTGTAGCTGAAAGTCACTGTTGTCTAAAACTAACTTTTCTAAGTTA
TCAAAACAACCTAATTTCTTTTCCAACAAGGAGAACTTAATGGCATGAAGGATTGTGTGACACATTGGAAAAGCCAGCTTACTGCCACTC
TCTTCCTTTGGCCATTAGAGGGAGGTGTTGCCTTTCATTGACGCTTAGAAGCAAATTGTTCACTTGTTAAGAAAAGTAAATCCTTAAAAA
AAGAAAAGGAAAAAATTTAACCAATTTTTCTTAATACCCAGAAGGAATTATACTCAATATTTCCCTAGTTAAGAAAAGAGGAGATAATGT
TCGTCTAAAAAACTCCAACGTTGTAATTACAACTCTACATTCATTTACTTACTTGACATACTGCCACAAAGTAGTTTTTGAGTTCATTAA
AAATTCCAAAGGCATTAGTTGTTTTTTTTTTTTTTAGTGTTTTGTTTTTTAGTTAACTTTTATAGACATTTTAGTAACTTGCTAAAGATT
CAGGGGATTCTATGAAACCCCGAATTTAGAAACATCTGGTCTACCTCAGTTAAATGTTGACTGCTTAGAAATATAGCTGAAGTGATCACC
ACAGCCATAAAATTGTTTAAGAAAGATTTATATAATGTTTACAAATCTGGAATCAAGGATTTTAGCTGAAATCCTTTAAGAGATATTAGA
GCAAGTATTTAATTCAGGTATTTTCAAGTTTTAAAACTTAACCTGTTTACCTACTAAAAATAAAATAGCTAGTTTTTTTCTGCATATAAA
AGTTCATTGAAATGATATGCCCTTATTTGCAATACTTTTCCCATAAAGTTTTAAGTGTGAAAGAATTGTAATTTACTAGATATGTTTGGT
ATGGGATATTTTGTTAGGCAAGTTTTCTTTTTTCTTCTTAAATTGCAATAGGCTTCCAAAAAGAGTATAATTGTTTCAGAACAAATTAAC
TCTTGGCATTATACGTCTCCCTTTTTCTTTACAGTATTAGTAAAAAGAAAAATTGTACACTTTCTGATTTTAACTTCACTAATGTAATTA
CTCTCTCAAGAAGCTTTTAAAATTTAAATTACCATCACACAACCTTTTTTATAGTAAAGCCAACATTTGTTCTCTCACCAAACCCCATGC
CAAATTCATCATGAAGAAAGCTCAGCATAAGTAATTCAAATACTGCTTATAATTTTAGAGGGGGGTAGAATTTAGTAAATATTCCAGCCG
GTCGTTTTATGCACAAGGCTTCAGTCAGAACATAGAAAAAAAAAACATTCTGTGAATGAAATATTGTATGTTCAGATTTTATAAAAGACA
TTTTTAAAAGCCCAATTTACAGCCGTATATTTTCTTATGATGTAATTTATGAAAAAGATGTCTGTACTAACAGGTGCTGTAACACTACTG
TTGTTGGATTTTATTGTTTGGTGATAAATGTATACAATATTTCTAAGGGAAACTATGTACTGTGATGTAAAAGTCTGGGCAAAATGTATA
TAATCCTGTATATAATTATGTATTTGATTATAATTACTGATTGTAAAGATTTAATAAAATATGTAAATATTCCAGTTTAGTTTTAATTTG
AATTTTTAGAATCACTGTGCATATCCTCATACTTTTATGTCTTGATGTTTATCACTCTGTTTTCCTTTTTTTTTTAAACTCATTTTATCC
TCCGGGGATTGAATTCTGGGGACATTTTAGGCTGTAGAAACCCAAGCTTGTGGGCTAAAGTAAGGATTTTGTTCTAAGAAATCACTGAAA

>In-frame_ENST00000258399_ENST00000318130_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(amino acids)=430AA_start in transcript=711_stop in transcript=2003
MQSIKTDFLQTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEIL
KKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRG
FVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEG
SIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPESLSLADMDNAASISPSE

--------------------------------------------------------------
>In-frame_ENST00000258399_ENST00000367512_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(transcript)=2292nt_BP=741nt
GTGCGTGCGTGTTTGCGTGTGGTCACAGTTCCCGCCATCAGCCGCTCTCCCTGACTAGGGGTAGCTAGCGGCCTCCCTCCTTTGGGTTCG
GTATCCCTACTTCCATTACCCTCGGCTCCTCCCACTCCTCGCGGGCTCCGTGCTTTCCGCGGGTCTGTCCGGGGGCTCCGGACCCTCGGC
GCAGCTGAGTTGATGGCTTCCGGAGAACTGGCATAGCTGCAGAATATGAGTAGTGTCCCAAGAAGAGTGCTTTGCCTTTGGCACAAGGAT
CAGAATAAAGGTGAATTGCTATTACATAGGGTTTTTCGGTAAAAGTCACTGAAAATTATTTGCCATACAGTAACCAGAGACCTCCAACTA
GGGGCCCCCAAACTGTATCCTGCCTGTAGCCAGAAGCAATTTTTAAAGAAAATATGTCTCCTCTGAAGATACATGGTCCTATCAGAATTC
GAAGTATGCAGACTGGGATTACAAAGTGGAAAGAAGGATCCTTTGAAATTGTAGAAAAAGAGAATAAAGTCAGCCTAGTAGTTCACTACA
ATACTGGAGGAATTCCAAGGATATTTCAGCTAAGTCATAACATTAAAAATGTGGTGCTTCGACCCAGTGGAGCGAAACAAAGCCGCCTAA
TGTTAACTCTGCAAGATAACAGCTTCTTGTCTATTGACAAAGTACCAAGTAAGGATGCAGAGGAAATGAGGTTGTTTCTAGATGCAGTCC
ATCAAAACAGACTTCCTGCAGACCTCGGAATATACAGAACTGGATGACAGTAACTTCGATTGGACTTGTCCAAATACTCAGATCCTCTTT
CCTAATGACCCATTGTATGCTCAAAGTATTCGTGAGCCCTTGAAAAATGTGGTGGATAAGAGCTGTCCTAGAGGCATCATCAGAGTAGAG
GAGAGTTTCAGGAGTGGAGCTAAACCCCCTCTGAGAGCCAGAGATTTCATGGCCACTAACCCTGAGCATTTAGAAATCCTGAAGAAGATG
GGGGTGAGTTTGATTCACCTCAAAGATGGGAGAGTCCAGTTGGTCCAACATGCAATCCAAGCTGCTAGTTCAATCGACGCTGAAGATGGG
TTGAGGTTCATGCAGGAGATGATTGAATTGTCAAGTCAGCAACAAAAAGAACAGCAGCTGCCTCCACGAGCTGTACAAATTGTTTCCCAC
CCATTTTTTGGCAGGGTAGTATTGACTGCTGGACCAGCTCAGTTTGGGCTGGATCTGTCTAAACATAAAGAGACAAGAGGATTTGTTGCA
AGCAGTAAACCATCCAATGGTTGTTCAGAGCTTACTAACCCAGAGGCAGTGATGGGAAAAATCGCACTGATACAAAGAGGACAGTGCATG
TTTGCAGAAAAGGCACGCAACATCCAGAATGCTGGAGCCATTGGTGGCATTGTTATTGATGACAATGAGGGGAGCAGCAGTGATACTGCC
CCTCTGTTCCAGATGGCAGGTGATGGAAAGGATACAGATGACATCAAGATCCCCATGCTGTTCTTATTCAGCAAAGAAGGAAGTATCATA
CTGGATGCCATCCGGGAATATGAGGAGGTAGAAGTGCTCCTCTCTGATAAAGCAAAAGATCGAGCAGCAATATTAAAAGGTAAAATGATT
CCAAGCTACATTATTAATAGTAATCCTGAAATGGAAAATGAAGAACAACCATCCTCTGAAAATGATTCTCAGAATCAGAGTGGTGAACAG
ATTTCATCAAGTTCTCAGGAGGTTGATTTGGTTGATCAAGAGTCTTCTGAGGAAAATTCTCTAAATTCTCACCCAGAATCATTATCTCTA
GCAGATATGGACAATGCTGCAAGCATTTCCCCTTCTGAACAGACTTCTAATCCCACAGAAAACCATGAGACTACAAATCTTAATGGTGAA
TGTACAGATTTAGATAACCAGCTTCAAGAACAATCAGAAACTGAGGAAGATTCCAATCCTAATGTTAGCTGGGGTAAAAAGGTCCAGCCT
ATAGACTCCATATTAGCAGACTGGAATGAAGATATAGAAGCATTTGAAATGATGGAGAAGGATGAGCTATGACTTGCTAAACAATCTGTT
GGTAGGTATTTAAAAAGAAAAGGTAAACTGTGTGTGGTTAATAGACATCCTAATACTAAGCAGGCTTTCTAATGGGAGGCTTTAAGTATG
GTGATGAACAACCACGTTCTGACTGGCGTAGTTATCGTAGGAATCTGGAGCATGCTGTGTTAGAATTGACCTTGTTTAAAACTGTCCCAT

>In-frame_ENST00000258399_ENST00000367512_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(amino acids)=446AA_start in transcript=711_stop in transcript=2051
MQSIKTDFLQTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEIL
KKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRG
FVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEG
SIILDAIREYEEVEVLLSDKAKDRAAILKGKMIPSYIINSNPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPES

--------------------------------------------------------------
>In-frame_ENST00000415516_ENST00000318130_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(transcript)=5636nt_BP=541nt
GGTCACAGTTCCCGCCATCAGCCGCTCTCCCTGACTAGGGGTAGCTAGCGGCCTCCCTCCTTTGGGTTCGGTATCCCTACTTCCATTACC
CTCGGCTCCTCCCACTCCTCGCGGGCTCCGTGCTTTCCGCGGGTCTGTCCGGGGGCTCCGGACCCTCGGCGCAGCTGAGTTGATGGCTTC
CGGAGAACTGGCATAGCTGCAGAATATGAGTAGTGTCCCAAGAAGAGTGCTTTGCCTTTGGCACAAGGATCAGAATAAAGGTGAATTGCT
ATTACATAGGGTTTTTCGGTAAAAGTCACTGAAAATTATTTGCCATACAGTAACCAGAGACCTCCAACTAGGGGCCCCCAAACTGTATCC
TGCCTGTAGCTAAGTCATAACATTAAAAATGTGGTGCTTCGACCCAGTGGAGCGAAACAAAGCCGCCTAATGTTAACTCTGCAAGATAAC
AGCTTCTTGTCTATTGACAAAGTACCAAGTAAGGATGCAGAGGAAATGAGGTTGTTTCTAGATGCAGTCCATCAAAACAGACTTCCTGCA
GACCTCGGAATATACAGAACTGGATGACAGTAACTTCGATTGGACTTGTCCAAATACTCAGATCCTCTTTCCTAATGACCCATTGTATGC
TCAAAGTATTCGTGAGCCCTTGAAAAATGTGGTGGATAAGAGCTGTCCTAGAGGCATCATCAGAGTAGAGGAGAGTTTCAGGAGTGGAGC
TAAACCCCCTCTGAGAGCCAGAGATTTCATGGCCACTAACCCTGAGCATTTAGAAATCCTGAAGAAGATGGGGGTGAGTTTGATTCACCT
CAAAGATGGGAGAGTCCAGTTGGTCCAACATGCAATCCAAGCTGCTAGTTCAATCGACGCTGAAGATGGGTTGAGGTTCATGCAGGAGAT
GATTGAATTGTCAAGTCAGCAACAAAAAGAACAGCAGCTGCCTCCACGAGCTGTACAAATTGTTTCCCACCCATTTTTTGGCAGGGTAGT
ATTGACTGCTGGACCAGCTCAGTTTGGGCTGGATCTGTCTAAACATAAAGAGACAAGAGGATTTGTTGCAAGCAGTAAACCATCCAATGG
TTGTTCAGAGCTTACTAACCCAGAGGCAGTGATGGGAAAAATCGCACTGATACAAAGAGGACAGTGCATGTTTGCAGAAAAGGCACGCAA
CATCCAGAATGCTGGAGCCATTGGTGGCATTGTTATTGATGACAATGAGGGGAGCAGCAGTGATACTGCCCCTCTGTTCCAGATGGCAGG
TGATGGAAAGGATACAGATGACATCAAGATCCCCATGCTGTTCTTATTCAGCAAAGAAGGAAGTATCATACTGGATGCCATCCGGGAATA
TGAGGAGGTAGAAGTGCTCCTCTCTGATAAAGCAAAAGATCGAGATCCTGAAATGGAAAATGAAGAACAACCATCCTCTGAAAATGATTC
TCAGAATCAGAGTGGTGAACAGATTTCATCAAGTTCTCAGGAGGTTGATTTGGTTGATCAAGAGTCTTCTGAGGAAAATTCTCTAAATTC
TCACCCAGAATCATTATCTCTAGCAGATATGGACAATGCTGCAAGCATTTCCCCTTCTGAACAGACTTCTAATCCCACAGAAAACCATGA
GACTACAAATCTTAATGGTGAATGTACAGATTTAGATAACCAGCTTCAAGAACAATCAGAAACTGAGGAAGATTCCAATCCTAATGTTAG
CTGGGGTAAAAAGGTCCAGCCTATAGACTCCATATTAGCAGACTGGAATGAAGATATAGAAGCATTTGAAATGATGGAGAAGGATGAGCT
ATGACTTGCTAAACAATCTGTTGGTAGGTATTTAAAAAGAAAAGGTAAACTGTGTGTGGTTAATAGACATCCTAATACTAAGCAGGCTTT
CTAATGGGAGGCTTTAAGTATGGTGATGAACAACCACGTTCTGACTGGCGTAGTTATCGTAGGAATCTGGAGCATGCTGTGTTAGAATTG
ACCTTGTTTAAAACTGTCCCATCAAAAATGGAAATCCACAGTTCCCCCTTCAAATGCAGCACTGCACCACCCTGCAACACCTCAGGCCAG
GGAAAGATTACTGAGCATTCCTGCGAACCAGATTTCTGTTGTCTCTGGATAGACAAGAAACAAAATTCATTTAGTAGTGGAGTGGGGAAT
AGGAGTTTGGATAGCCTTCTAATTAAAGGAAGCTCGCCTTTCTTGGTTTTGGGGGTTAGAGGCTCTTTTGGGAAGATGCATCCGAGTATT
GTGGCATTCTGATTATGCTGCCTTCACAAAACACTCTAAGTGACCTAAGTGGTTATGAAGCAAATGCATTTATGGTGAAAACAGTCTTTG
CTCATTGCTTTCTCTTGTTTCATTTAGTGACAAATGATCAAGATGACTTGATTTTTTTTCCTTCTTAACAATGTCTTTTTTATTTAAACC
AAAGGTGAAGCCAGTGTACTTTCTCAGTGAGTTCTCTGCATAAAGACTAATCAGTGGGACCAGGTAAAAAGGTCATATAATACATTGTGG
AGATTGCTTACTTAATACTTCTGAAAAATGGAGTAAGGGAGAAACTGTAATGTTGCAATATGAACCTCCCATTGGGCCTTCCATAGGGAA
AGCTGTGACTACTCTGAAATGGAACCTAGCATTATATCCTTGTAGGGTAGATTATAAATCATTTCCAGTTCATTTCTCTTAGAGGTGATT
ACCTCTAGCCATCAGCCTTACTCCATCCCATGTTTGGTATGCAATTTGAGCCACAAGGCTCGTATCGCCAACAGCTATATACATTTTGTT
CCATTTTTCTGTCTTACAGAGCCATGATAGAACTGTGGTTAGTGAGTTAAAATTCCTGGAGTAACTACTGTTTTTCTCCTTTGAAACTTA
GGTTTCTAAAGTTGCACCTAAGGAATCTGTCACATTTTCTGTTGAATCATGGTTTTTGTTTTTGTTTTTAACAGATATTCCTTCTGATAC
GGACTTGAAAATTAGTGTATGGTGACCTGTGTTTAAAAAAAAAAGTACAATACAACTACATATAGCTATATAGCTTAATGAGACTTCCAC
CCCCCCCCTTTTTTTTTTTGGTTTGTTGTTGTTGTAGTAGTCTGGTGCTGGCCACATTTAAGTCTTAAAAATTTTTAAATTTTGTTGTTG
ATGTTTGTAGACAGCCCTGTTGTTGAAATCATGGCTTTATTCATTTTATTTATTTTTTAAACTTGCCTGAATTTGTTCTAAAGGAATATT
TAAGAGACATAATTTTCTTCTCTTTACCATAACATTACACAAAACTTTTTCCTAAAACACGGTTGTGAGGTACTGATGAGGTGTAAGTGG
AGCTGTTAAAAACAGCAGTGCTGTATTGCAGTTATGTATATTCGTGTACAGTATGTTTAGATCCCAGGTAAACATATTCTTTTCTGAGAG
GATAAATACCTGCATTCAGATATTCCAGGTAAATATAATTGAGTCAGGGAGTAGTAAATCTGATGGAGAATTCACTTTGGGGAGGGGAAA
AAGAATAGTATGCAAGACCCTTATTGGCTTTTAATTATACCTGAAACCAAAATGGATATTTTTAGTCTCTCTGCATGTGAGATTTGGTGT
AACAAGATAGAACTATAATATATACAGTATATGGAAGGATAGATATAGTGCTTTGTTCATTTTAATTGCAAAGCTGCCAAAATAGTTGAA
GCTTAATTACTTGACTTGCCTTGATTTATAGGACTGGGGCTTGGAGAAAATGAGCAGATGTTCCTCTAAGACATCGATTACAGAAGCCTT
ATATACATGGATTTGATTTTGTATTTGTAGCTGAAAGTCACTGTTGTCTAAAACTAACTTTTCTAAGTTATCAAAACAACCTAATTTCTT
TTCCAACAAGGAGAACTTAATGGCATGAAGGATTGTGTGACACATTGGAAAAGCCAGCTTACTGCCACTCTCTTCCTTTGGCCATTAGAG
GGAGGTGTTGCCTTTCATTGACGCTTAGAAGCAAATTGTTCACTTGTTAAGAAAAGTAAATCCTTAAAAAAAGAAAAGGAAAAAATTTAA
CCAATTTTTCTTAATACCCAGAAGGAATTATACTCAATATTTCCCTAGTTAAGAAAAGAGGAGATAATGTTCGTCTAAAAAACTCCAACG
TTGTAATTACAACTCTACATTCATTTACTTACTTGACATACTGCCACAAAGTAGTTTTTGAGTTCATTAAAAATTCCAAAGGCATTAGTT
GTTTTTTTTTTTTTTAGTGTTTTGTTTTTTAGTTAACTTTTATAGACATTTTAGTAACTTGCTAAAGATTCAGGGGATTCTATGAAACCC
CGAATTTAGAAACATCTGGTCTACCTCAGTTAAATGTTGACTGCTTAGAAATATAGCTGAAGTGATCACCACAGCCATAAAATTGTTTAA
GAAAGATTTATATAATGTTTACAAATCTGGAATCAAGGATTTTAGCTGAAATCCTTTAAGAGATATTAGAGCAAGTATTTAATTCAGGTA
TTTTCAAGTTTTAAAACTTAACCTGTTTACCTACTAAAAATAAAATAGCTAGTTTTTTTCTGCATATAAAAGTTCATTGAAATGATATGC
CCTTATTTGCAATACTTTTCCCATAAAGTTTTAAGTGTGAAAGAATTGTAATTTACTAGATATGTTTGGTATGGGATATTTTGTTAGGCA
AGTTTTCTTTTTTCTTCTTAAATTGCAATAGGCTTCCAAAAAGAGTATAATTGTTTCAGAACAAATTAACTCTTGGCATTATACGTCTCC
CTTTTTCTTTACAGTATTAGTAAAAAGAAAAATTGTACACTTTCTGATTTTAACTTCACTAATGTAATTACTCTCTCAAGAAGCTTTTAA
AATTTAAATTACCATCACACAACCTTTTTTATAGTAAAGCCAACATTTGTTCTCTCACCAAACCCCATGCCAAATTCATCATGAAGAAAG
CTCAGCATAAGTAATTCAAATACTGCTTATAATTTTAGAGGGGGGTAGAATTTAGTAAATATTCCAGCCGGTCGTTTTATGCACAAGGCT
TCAGTCAGAACATAGAAAAAAAAAACATTCTGTGAATGAAATATTGTATGTTCAGATTTTATAAAAGACATTTTTAAAAGCCCAATTTAC
AGCCGTATATTTTCTTATGATGTAATTTATGAAAAAGATGTCTGTACTAACAGGTGCTGTAACACTACTGTTGTTGGATTTTATTGTTTG
GTGATAAATGTATACAATATTTCTAAGGGAAACTATGTACTGTGATGTAAAAGTCTGGGCAAAATGTATATAATCCTGTATATAATTATG
TATTTGATTATAATTACTGATTGTAAAGATTTAATAAAATATGTAAATATTCCAGTTTAGTTTTAATTTGAATTTTTAGAATCACTGTGC
ATATCCTCATACTTTTATGTCTTGATGTTTATCACTCTGTTTTCCTTTTTTTTTTAAACTCATTTTATCCTCCGGGGATTGAATTCTGGG
GACATTTTAGGCTGTAGAAACCCAAGCTTGTGGGCTAAAGTAAGGATTTTGTTCTAAGAAATCACTGAAAGTTTTTCAACAAGTCAGTAG

>In-frame_ENST00000415516_ENST00000318130_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(amino acids)=430AA_start in transcript=511_stop in transcript=1803
MQSIKTDFLQTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEIL
KKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRG
FVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEG
SIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPESLSLADMDNAASISPSE

--------------------------------------------------------------
>In-frame_ENST00000415516_ENST00000367512_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(transcript)=2092nt_BP=541nt
GGTCACAGTTCCCGCCATCAGCCGCTCTCCCTGACTAGGGGTAGCTAGCGGCCTCCCTCCTTTGGGTTCGGTATCCCTACTTCCATTACC
CTCGGCTCCTCCCACTCCTCGCGGGCTCCGTGCTTTCCGCGGGTCTGTCCGGGGGCTCCGGACCCTCGGCGCAGCTGAGTTGATGGCTTC
CGGAGAACTGGCATAGCTGCAGAATATGAGTAGTGTCCCAAGAAGAGTGCTTTGCCTTTGGCACAAGGATCAGAATAAAGGTGAATTGCT
ATTACATAGGGTTTTTCGGTAAAAGTCACTGAAAATTATTTGCCATACAGTAACCAGAGACCTCCAACTAGGGGCCCCCAAACTGTATCC
TGCCTGTAGCTAAGTCATAACATTAAAAATGTGGTGCTTCGACCCAGTGGAGCGAAACAAAGCCGCCTAATGTTAACTCTGCAAGATAAC
AGCTTCTTGTCTATTGACAAAGTACCAAGTAAGGATGCAGAGGAAATGAGGTTGTTTCTAGATGCAGTCCATCAAAACAGACTTCCTGCA
GACCTCGGAATATACAGAACTGGATGACAGTAACTTCGATTGGACTTGTCCAAATACTCAGATCCTCTTTCCTAATGACCCATTGTATGC
TCAAAGTATTCGTGAGCCCTTGAAAAATGTGGTGGATAAGAGCTGTCCTAGAGGCATCATCAGAGTAGAGGAGAGTTTCAGGAGTGGAGC
TAAACCCCCTCTGAGAGCCAGAGATTTCATGGCCACTAACCCTGAGCATTTAGAAATCCTGAAGAAGATGGGGGTGAGTTTGATTCACCT
CAAAGATGGGAGAGTCCAGTTGGTCCAACATGCAATCCAAGCTGCTAGTTCAATCGACGCTGAAGATGGGTTGAGGTTCATGCAGGAGAT
GATTGAATTGTCAAGTCAGCAACAAAAAGAACAGCAGCTGCCTCCACGAGCTGTACAAATTGTTTCCCACCCATTTTTTGGCAGGGTAGT
ATTGACTGCTGGACCAGCTCAGTTTGGGCTGGATCTGTCTAAACATAAAGAGACAAGAGGATTTGTTGCAAGCAGTAAACCATCCAATGG
TTGTTCAGAGCTTACTAACCCAGAGGCAGTGATGGGAAAAATCGCACTGATACAAAGAGGACAGTGCATGTTTGCAGAAAAGGCACGCAA
CATCCAGAATGCTGGAGCCATTGGTGGCATTGTTATTGATGACAATGAGGGGAGCAGCAGTGATACTGCCCCTCTGTTCCAGATGGCAGG
TGATGGAAAGGATACAGATGACATCAAGATCCCCATGCTGTTCTTATTCAGCAAAGAAGGAAGTATCATACTGGATGCCATCCGGGAATA
TGAGGAGGTAGAAGTGCTCCTCTCTGATAAAGCAAAAGATCGAGCAGCAATATTAAAAGGTAAAATGATTCCAAGCTACATTATTAATAG
TAATCCTGAAATGGAAAATGAAGAACAACCATCCTCTGAAAATGATTCTCAGAATCAGAGTGGTGAACAGATTTCATCAAGTTCTCAGGA
GGTTGATTTGGTTGATCAAGAGTCTTCTGAGGAAAATTCTCTAAATTCTCACCCAGAATCATTATCTCTAGCAGATATGGACAATGCTGC
AAGCATTTCCCCTTCTGAACAGACTTCTAATCCCACAGAAAACCATGAGACTACAAATCTTAATGGTGAATGTACAGATTTAGATAACCA
GCTTCAAGAACAATCAGAAACTGAGGAAGATTCCAATCCTAATGTTAGCTGGGGTAAAAAGGTCCAGCCTATAGACTCCATATTAGCAGA
CTGGAATGAAGATATAGAAGCATTTGAAATGATGGAGAAGGATGAGCTATGACTTGCTAAACAATCTGTTGGTAGGTATTTAAAAAGAAA
AGGTAAACTGTGTGTGGTTAATAGACATCCTAATACTAAGCAGGCTTTCTAATGGGAGGCTTTAAGTATGGTGATGAACAACCACGTTCT
GACTGGCGTAGTTATCGTAGGAATCTGGAGCATGCTGTGTTAGAATTGACCTTGTTTAAAACTGTCCCATCAAAAATGGAAATCCACAGT

>In-frame_ENST00000415516_ENST00000367512_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(amino acids)=446AA_start in transcript=511_stop in transcript=1851
MQSIKTDFLQTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEIL
KKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRG
FVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEG
SIILDAIREYEEVEVLLSDKAKDRAAILKGKMIPSYIINSNPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPES

--------------------------------------------------------------
>In-frame_ENST00000418019_ENST00000318130_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(transcript)=5721nt_BP=626nt
GCCTCCCTCCTTTGGGTTCGGTATCCCTACTTCCATTACCCTCGGCTCCTCCCACTCCTCGCGGGCTCCGTGCTTTCCGCGGGTCTGTCC
GGGGGCTCCGGACCCTCGGCGCAGCTGAGTTGATGGCTTCCGGAGAACTGGCATAGCTGCAGAATATGAGTAGTGTCCCAAGAAGAGTGC
TTTGCCTTTGGCACAAGGATCAGAATAAAGTTATTTGCCATACAGTAACCAGAGACCTCCAACTAGGGGCCCCCAAACTGTATCCTGCCT
GTAGCCAGAAGCAATTTTTAAAGAAAATATGTCTCCTCTGAAGATACATGGTCCTATCAGAATTCGAAGTATGCAGACTGGGATTACAAA
GTGGAAAGAAGGATCCTTTGAAATTGTAGAAAAAGAGAATAAAGTCAGCCTAGTAGTTCACTACAATACTGGAGGAATTCCAAGGATATT
TCAGCTAAGTCATAACATTAAAAATGTGGTGCTTCGACCCAGTGGAGCGAAACAAAGCCGCCTAATGTTAACTCTGCAAGATAACAGCTT
CTTGTCTATTGACAAAGTACCAAGTAAGGATGCAGAGGAAATGAGGTTGTTTCTAGATGCAGTCCATCAAAACAGACTTCCTGCAGACCT
CGGAATATACAGAACTGGATGACAGTAACTTCGATTGGACTTGTCCAAATACTCAGATCCTCTTTCCTAATGACCCATTGTATGCTCAAA
GTATTCGTGAGCCCTTGAAAAATGTGGTGGATAAGAGCTGTCCTAGAGGCATCATCAGAGTAGAGGAGAGTTTCAGGAGTGGAGCTAAAC
CCCCTCTGAGAGCCAGAGATTTCATGGCCACTAACCCTGAGCATTTAGAAATCCTGAAGAAGATGGGGGTGAGTTTGATTCACCTCAAAG
ATGGGAGAGTCCAGTTGGTCCAACATGCAATCCAAGCTGCTAGTTCAATCGACGCTGAAGATGGGTTGAGGTTCATGCAGGAGATGATTG
AATTGTCAAGTCAGCAACAAAAAGAACAGCAGCTGCCTCCACGAGCTGTACAAATTGTTTCCCACCCATTTTTTGGCAGGGTAGTATTGA
CTGCTGGACCAGCTCAGTTTGGGCTGGATCTGTCTAAACATAAAGAGACAAGAGGATTTGTTGCAAGCAGTAAACCATCCAATGGTTGTT
CAGAGCTTACTAACCCAGAGGCAGTGATGGGAAAAATCGCACTGATACAAAGAGGACAGTGCATGTTTGCAGAAAAGGCACGCAACATCC
AGAATGCTGGAGCCATTGGTGGCATTGTTATTGATGACAATGAGGGGAGCAGCAGTGATACTGCCCCTCTGTTCCAGATGGCAGGTGATG
GAAAGGATACAGATGACATCAAGATCCCCATGCTGTTCTTATTCAGCAAAGAAGGAAGTATCATACTGGATGCCATCCGGGAATATGAGG
AGGTAGAAGTGCTCCTCTCTGATAAAGCAAAAGATCGAGATCCTGAAATGGAAAATGAAGAACAACCATCCTCTGAAAATGATTCTCAGA
ATCAGAGTGGTGAACAGATTTCATCAAGTTCTCAGGAGGTTGATTTGGTTGATCAAGAGTCTTCTGAGGAAAATTCTCTAAATTCTCACC
CAGAATCATTATCTCTAGCAGATATGGACAATGCTGCAAGCATTTCCCCTTCTGAACAGACTTCTAATCCCACAGAAAACCATGAGACTA
CAAATCTTAATGGTGAATGTACAGATTTAGATAACCAGCTTCAAGAACAATCAGAAACTGAGGAAGATTCCAATCCTAATGTTAGCTGGG
GTAAAAAGGTCCAGCCTATAGACTCCATATTAGCAGACTGGAATGAAGATATAGAAGCATTTGAAATGATGGAGAAGGATGAGCTATGAC
TTGCTAAACAATCTGTTGGTAGGTATTTAAAAAGAAAAGGTAAACTGTGTGTGGTTAATAGACATCCTAATACTAAGCAGGCTTTCTAAT
GGGAGGCTTTAAGTATGGTGATGAACAACCACGTTCTGACTGGCGTAGTTATCGTAGGAATCTGGAGCATGCTGTGTTAGAATTGACCTT
GTTTAAAACTGTCCCATCAAAAATGGAAATCCACAGTTCCCCCTTCAAATGCAGCACTGCACCACCCTGCAACACCTCAGGCCAGGGAAA
GATTACTGAGCATTCCTGCGAACCAGATTTCTGTTGTCTCTGGATAGACAAGAAACAAAATTCATTTAGTAGTGGAGTGGGGAATAGGAG
TTTGGATAGCCTTCTAATTAAAGGAAGCTCGCCTTTCTTGGTTTTGGGGGTTAGAGGCTCTTTTGGGAAGATGCATCCGAGTATTGTGGC
ATTCTGATTATGCTGCCTTCACAAAACACTCTAAGTGACCTAAGTGGTTATGAAGCAAATGCATTTATGGTGAAAACAGTCTTTGCTCAT
TGCTTTCTCTTGTTTCATTTAGTGACAAATGATCAAGATGACTTGATTTTTTTTCCTTCTTAACAATGTCTTTTTTATTTAAACCAAAGG
TGAAGCCAGTGTACTTTCTCAGTGAGTTCTCTGCATAAAGACTAATCAGTGGGACCAGGTAAAAAGGTCATATAATACATTGTGGAGATT
GCTTACTTAATACTTCTGAAAAATGGAGTAAGGGAGAAACTGTAATGTTGCAATATGAACCTCCCATTGGGCCTTCCATAGGGAAAGCTG
TGACTACTCTGAAATGGAACCTAGCATTATATCCTTGTAGGGTAGATTATAAATCATTTCCAGTTCATTTCTCTTAGAGGTGATTACCTC
TAGCCATCAGCCTTACTCCATCCCATGTTTGGTATGCAATTTGAGCCACAAGGCTCGTATCGCCAACAGCTATATACATTTTGTTCCATT
TTTCTGTCTTACAGAGCCATGATAGAACTGTGGTTAGTGAGTTAAAATTCCTGGAGTAACTACTGTTTTTCTCCTTTGAAACTTAGGTTT
CTAAAGTTGCACCTAAGGAATCTGTCACATTTTCTGTTGAATCATGGTTTTTGTTTTTGTTTTTAACAGATATTCCTTCTGATACGGACT
TGAAAATTAGTGTATGGTGACCTGTGTTTAAAAAAAAAAGTACAATACAACTACATATAGCTATATAGCTTAATGAGACTTCCACCCCCC
CCCTTTTTTTTTTTGGTTTGTTGTTGTTGTAGTAGTCTGGTGCTGGCCACATTTAAGTCTTAAAAATTTTTAAATTTTGTTGTTGATGTT
TGTAGACAGCCCTGTTGTTGAAATCATGGCTTTATTCATTTTATTTATTTTTTAAACTTGCCTGAATTTGTTCTAAAGGAATATTTAAGA
GACATAATTTTCTTCTCTTTACCATAACATTACACAAAACTTTTTCCTAAAACACGGTTGTGAGGTACTGATGAGGTGTAAGTGGAGCTG
TTAAAAACAGCAGTGCTGTATTGCAGTTATGTATATTCGTGTACAGTATGTTTAGATCCCAGGTAAACATATTCTTTTCTGAGAGGATAA
ATACCTGCATTCAGATATTCCAGGTAAATATAATTGAGTCAGGGAGTAGTAAATCTGATGGAGAATTCACTTTGGGGAGGGGAAAAAGAA
TAGTATGCAAGACCCTTATTGGCTTTTAATTATACCTGAAACCAAAATGGATATTTTTAGTCTCTCTGCATGTGAGATTTGGTGTAACAA
GATAGAACTATAATATATACAGTATATGGAAGGATAGATATAGTGCTTTGTTCATTTTAATTGCAAAGCTGCCAAAATAGTTGAAGCTTA
ATTACTTGACTTGCCTTGATTTATAGGACTGGGGCTTGGAGAAAATGAGCAGATGTTCCTCTAAGACATCGATTACAGAAGCCTTATATA
CATGGATTTGATTTTGTATTTGTAGCTGAAAGTCACTGTTGTCTAAAACTAACTTTTCTAAGTTATCAAAACAACCTAATTTCTTTTCCA
ACAAGGAGAACTTAATGGCATGAAGGATTGTGTGACACATTGGAAAAGCCAGCTTACTGCCACTCTCTTCCTTTGGCCATTAGAGGGAGG
TGTTGCCTTTCATTGACGCTTAGAAGCAAATTGTTCACTTGTTAAGAAAAGTAAATCCTTAAAAAAAGAAAAGGAAAAAATTTAACCAAT
TTTTCTTAATACCCAGAAGGAATTATACTCAATATTTCCCTAGTTAAGAAAAGAGGAGATAATGTTCGTCTAAAAAACTCCAACGTTGTA
ATTACAACTCTACATTCATTTACTTACTTGACATACTGCCACAAAGTAGTTTTTGAGTTCATTAAAAATTCCAAAGGCATTAGTTGTTTT
TTTTTTTTTTAGTGTTTTGTTTTTTAGTTAACTTTTATAGACATTTTAGTAACTTGCTAAAGATTCAGGGGATTCTATGAAACCCCGAAT
TTAGAAACATCTGGTCTACCTCAGTTAAATGTTGACTGCTTAGAAATATAGCTGAAGTGATCACCACAGCCATAAAATTGTTTAAGAAAG
ATTTATATAATGTTTACAAATCTGGAATCAAGGATTTTAGCTGAAATCCTTTAAGAGATATTAGAGCAAGTATTTAATTCAGGTATTTTC
AAGTTTTAAAACTTAACCTGTTTACCTACTAAAAATAAAATAGCTAGTTTTTTTCTGCATATAAAAGTTCATTGAAATGATATGCCCTTA
TTTGCAATACTTTTCCCATAAAGTTTTAAGTGTGAAAGAATTGTAATTTACTAGATATGTTTGGTATGGGATATTTTGTTAGGCAAGTTT
TCTTTTTTCTTCTTAAATTGCAATAGGCTTCCAAAAAGAGTATAATTGTTTCAGAACAAATTAACTCTTGGCATTATACGTCTCCCTTTT
TCTTTACAGTATTAGTAAAAAGAAAAATTGTACACTTTCTGATTTTAACTTCACTAATGTAATTACTCTCTCAAGAAGCTTTTAAAATTT
AAATTACCATCACACAACCTTTTTTATAGTAAAGCCAACATTTGTTCTCTCACCAAACCCCATGCCAAATTCATCATGAAGAAAGCTCAG
CATAAGTAATTCAAATACTGCTTATAATTTTAGAGGGGGGTAGAATTTAGTAAATATTCCAGCCGGTCGTTTTATGCACAAGGCTTCAGT
CAGAACATAGAAAAAAAAAACATTCTGTGAATGAAATATTGTATGTTCAGATTTTATAAAAGACATTTTTAAAAGCCCAATTTACAGCCG
TATATTTTCTTATGATGTAATTTATGAAAAAGATGTCTGTACTAACAGGTGCTGTAACACTACTGTTGTTGGATTTTATTGTTTGGTGAT
AAATGTATACAATATTTCTAAGGGAAACTATGTACTGTGATGTAAAAGTCTGGGCAAAATGTATATAATCCTGTATATAATTATGTATTT
GATTATAATTACTGATTGTAAAGATTTAATAAAATATGTAAATATTCCAGTTTAGTTTTAATTTGAATTTTTAGAATCACTGTGCATATC
CTCATACTTTTATGTCTTGATGTTTATCACTCTGTTTTCCTTTTTTTTTTAAACTCATTTTATCCTCCGGGGATTGAATTCTGGGGACAT
TTTAGGCTGTAGAAACCCAAGCTTGTGGGCTAAAGTAAGGATTTTGTTCTAAGAAATCACTGAAAGTTTTTCAACAAGTCAGTAGCATGC

>In-frame_ENST00000418019_ENST00000318130_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(amino acids)=430AA_start in transcript=596_stop in transcript=1888
MQSIKTDFLQTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEIL
KKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRG
FVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEG
SIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPESLSLADMDNAASISPSE

--------------------------------------------------------------
>In-frame_ENST00000418019_ENST00000367512_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(transcript)=2177nt_BP=626nt
GCCTCCCTCCTTTGGGTTCGGTATCCCTACTTCCATTACCCTCGGCTCCTCCCACTCCTCGCGGGCTCCGTGCTTTCCGCGGGTCTGTCC
GGGGGCTCCGGACCCTCGGCGCAGCTGAGTTGATGGCTTCCGGAGAACTGGCATAGCTGCAGAATATGAGTAGTGTCCCAAGAAGAGTGC
TTTGCCTTTGGCACAAGGATCAGAATAAAGTTATTTGCCATACAGTAACCAGAGACCTCCAACTAGGGGCCCCCAAACTGTATCCTGCCT
GTAGCCAGAAGCAATTTTTAAAGAAAATATGTCTCCTCTGAAGATACATGGTCCTATCAGAATTCGAAGTATGCAGACTGGGATTACAAA
GTGGAAAGAAGGATCCTTTGAAATTGTAGAAAAAGAGAATAAAGTCAGCCTAGTAGTTCACTACAATACTGGAGGAATTCCAAGGATATT
TCAGCTAAGTCATAACATTAAAAATGTGGTGCTTCGACCCAGTGGAGCGAAACAAAGCCGCCTAATGTTAACTCTGCAAGATAACAGCTT
CTTGTCTATTGACAAAGTACCAAGTAAGGATGCAGAGGAAATGAGGTTGTTTCTAGATGCAGTCCATCAAAACAGACTTCCTGCAGACCT
CGGAATATACAGAACTGGATGACAGTAACTTCGATTGGACTTGTCCAAATACTCAGATCCTCTTTCCTAATGACCCATTGTATGCTCAAA
GTATTCGTGAGCCCTTGAAAAATGTGGTGGATAAGAGCTGTCCTAGAGGCATCATCAGAGTAGAGGAGAGTTTCAGGAGTGGAGCTAAAC
CCCCTCTGAGAGCCAGAGATTTCATGGCCACTAACCCTGAGCATTTAGAAATCCTGAAGAAGATGGGGGTGAGTTTGATTCACCTCAAAG
ATGGGAGAGTCCAGTTGGTCCAACATGCAATCCAAGCTGCTAGTTCAATCGACGCTGAAGATGGGTTGAGGTTCATGCAGGAGATGATTG
AATTGTCAAGTCAGCAACAAAAAGAACAGCAGCTGCCTCCACGAGCTGTACAAATTGTTTCCCACCCATTTTTTGGCAGGGTAGTATTGA
CTGCTGGACCAGCTCAGTTTGGGCTGGATCTGTCTAAACATAAAGAGACAAGAGGATTTGTTGCAAGCAGTAAACCATCCAATGGTTGTT
CAGAGCTTACTAACCCAGAGGCAGTGATGGGAAAAATCGCACTGATACAAAGAGGACAGTGCATGTTTGCAGAAAAGGCACGCAACATCC
AGAATGCTGGAGCCATTGGTGGCATTGTTATTGATGACAATGAGGGGAGCAGCAGTGATACTGCCCCTCTGTTCCAGATGGCAGGTGATG
GAAAGGATACAGATGACATCAAGATCCCCATGCTGTTCTTATTCAGCAAAGAAGGAAGTATCATACTGGATGCCATCCGGGAATATGAGG
AGGTAGAAGTGCTCCTCTCTGATAAAGCAAAAGATCGAGCAGCAATATTAAAAGGTAAAATGATTCCAAGCTACATTATTAATAGTAATC
CTGAAATGGAAAATGAAGAACAACCATCCTCTGAAAATGATTCTCAGAATCAGAGTGGTGAACAGATTTCATCAAGTTCTCAGGAGGTTG
ATTTGGTTGATCAAGAGTCTTCTGAGGAAAATTCTCTAAATTCTCACCCAGAATCATTATCTCTAGCAGATATGGACAATGCTGCAAGCA
TTTCCCCTTCTGAACAGACTTCTAATCCCACAGAAAACCATGAGACTACAAATCTTAATGGTGAATGTACAGATTTAGATAACCAGCTTC
AAGAACAATCAGAAACTGAGGAAGATTCCAATCCTAATGTTAGCTGGGGTAAAAAGGTCCAGCCTATAGACTCCATATTAGCAGACTGGA
ATGAAGATATAGAAGCATTTGAAATGATGGAGAAGGATGAGCTATGACTTGCTAAACAATCTGTTGGTAGGTATTTAAAAAGAAAAGGTA
AACTGTGTGTGGTTAATAGACATCCTAATACTAAGCAGGCTTTCTAATGGGAGGCTTTAAGTATGGTGATGAACAACCACGTTCTGACTG
GCGTAGTTATCGTAGGAATCTGGAGCATGCTGTGTTAGAATTGACCTTGTTTAAAACTGTCCCATCAAAAATGGAAATCCACAGTTCCCC

>In-frame_ENST00000418019_ENST00000367512_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(amino acids)=446AA_start in transcript=596_stop in transcript=1936
MQSIKTDFLQTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEIL
KKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRG
FVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEG
SIILDAIREYEEVEVLLSDKAKDRAAILKGKMIPSYIINSNPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPES

--------------------------------------------------------------
>In-frame_ENST00000338465_ENST00000318130_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(transcript)=5801nt_BP=706nt
CATCAGCCGCTCTCCCTGACTAGGGGTAGCTAGCGGCCTCCCTCCTTTGGGTTCGGTATCCCTACTTCCATTACCCTCGGCTCCTCCCAC
TCCTCGCGGGCTCCGTGCTTTCCGCGGGTCTGTCCGGGGGCTCCGGACCCTCGGCGCAGCTGAGTTGATGGCTTCCGGAGAACTGGCATA
GCTGCAGAATATGAGTAGTGTCCCAAGAAGAGTGCTTTGCCTTTGGCACAAGGATCAGAATAAAGGTGAATTGCTATTACATAGGGTTTT
TCGGTAAAAGTCACTGAAAATTATTTGCCATACAGTAACCAGAGACCTCCAACTAGGGGCCCCCAAACTGTATCCTGCCTGTAGCCAGAA
GCAATTTTTAAAGAAAATATGTCTCCTCTGAAGATACATGGTCCTATCAGAATTCGAAGTATGCAGACTGGGATTACAAAGTGGAAAGAA
GGATCCTTTGAAATTGTAGAAAAAGAGAATAAAGTCAGCCTAGTAGTTCACTACAATACTGGAGGAATTCCAAGGATATTTCAGCTAAGT
CATAACATTAAAAATGTGGTGCTTCGACCCAGTGGAGCGAAACAAAGCCGCCTAATGTTAACTCTGCAAGATAACAGCTTCTTGTCTATT
GACAAAGTACCAAGTAAGGATGCAGAGGAAATGAGGTTGTTTCTAGATGCAGTCCATCAAAACAGACTTCCTGCAGACCTCGGAATATAC
AGAACTGGATGACAGTAACTTCGATTGGACTTGTCCAAATACTCAGATCCTCTTTCCTAATGACCCATTGTATGCTCAAAGTATTCGTGA
GCCCTTGAAAAATGTGGTGGATAAGAGCTGTCCTAGAGGCATCATCAGAGTAGAGGAGAGTTTCAGGAGTGGAGCTAAACCCCCTCTGAG
AGCCAGAGATTTCATGGCCACTAACCCTGAGCATTTAGAAATCCTGAAGAAGATGGGGGTGAGTTTGATTCACCTCAAAGATGGGAGAGT
CCAGTTGGTCCAACATGCAATCCAAGCTGCTAGTTCAATCGACGCTGAAGATGGGTTGAGGTTCATGCAGGAGATGATTGAATTGTCAAG
TCAGCAACAAAAAGAACAGCAGCTGCCTCCACGAGCTGTACAAATTGTTTCCCACCCATTTTTTGGCAGGGTAGTATTGACTGCTGGACC
AGCTCAGTTTGGGCTGGATCTGTCTAAACATAAAGAGACAAGAGGATTTGTTGCAAGCAGTAAACCATCCAATGGTTGTTCAGAGCTTAC
TAACCCAGAGGCAGTGATGGGAAAAATCGCACTGATACAAAGAGGACAGTGCATGTTTGCAGAAAAGGCACGCAACATCCAGAATGCTGG
AGCCATTGGTGGCATTGTTATTGATGACAATGAGGGGAGCAGCAGTGATACTGCCCCTCTGTTCCAGATGGCAGGTGATGGAAAGGATAC
AGATGACATCAAGATCCCCATGCTGTTCTTATTCAGCAAAGAAGGAAGTATCATACTGGATGCCATCCGGGAATATGAGGAGGTAGAAGT
GCTCCTCTCTGATAAAGCAAAAGATCGAGATCCTGAAATGGAAAATGAAGAACAACCATCCTCTGAAAATGATTCTCAGAATCAGAGTGG
TGAACAGATTTCATCAAGTTCTCAGGAGGTTGATTTGGTTGATCAAGAGTCTTCTGAGGAAAATTCTCTAAATTCTCACCCAGAATCATT
ATCTCTAGCAGATATGGACAATGCTGCAAGCATTTCCCCTTCTGAACAGACTTCTAATCCCACAGAAAACCATGAGACTACAAATCTTAA
TGGTGAATGTACAGATTTAGATAACCAGCTTCAAGAACAATCAGAAACTGAGGAAGATTCCAATCCTAATGTTAGCTGGGGTAAAAAGGT
CCAGCCTATAGACTCCATATTAGCAGACTGGAATGAAGATATAGAAGCATTTGAAATGATGGAGAAGGATGAGCTATGACTTGCTAAACA
ATCTGTTGGTAGGTATTTAAAAAGAAAAGGTAAACTGTGTGTGGTTAATAGACATCCTAATACTAAGCAGGCTTTCTAATGGGAGGCTTT
AAGTATGGTGATGAACAACCACGTTCTGACTGGCGTAGTTATCGTAGGAATCTGGAGCATGCTGTGTTAGAATTGACCTTGTTTAAAACT
GTCCCATCAAAAATGGAAATCCACAGTTCCCCCTTCAAATGCAGCACTGCACCACCCTGCAACACCTCAGGCCAGGGAAAGATTACTGAG
CATTCCTGCGAACCAGATTTCTGTTGTCTCTGGATAGACAAGAAACAAAATTCATTTAGTAGTGGAGTGGGGAATAGGAGTTTGGATAGC
CTTCTAATTAAAGGAAGCTCGCCTTTCTTGGTTTTGGGGGTTAGAGGCTCTTTTGGGAAGATGCATCCGAGTATTGTGGCATTCTGATTA
TGCTGCCTTCACAAAACACTCTAAGTGACCTAAGTGGTTATGAAGCAAATGCATTTATGGTGAAAACAGTCTTTGCTCATTGCTTTCTCT
TGTTTCATTTAGTGACAAATGATCAAGATGACTTGATTTTTTTTCCTTCTTAACAATGTCTTTTTTATTTAAACCAAAGGTGAAGCCAGT
GTACTTTCTCAGTGAGTTCTCTGCATAAAGACTAATCAGTGGGACCAGGTAAAAAGGTCATATAATACATTGTGGAGATTGCTTACTTAA
TACTTCTGAAAAATGGAGTAAGGGAGAAACTGTAATGTTGCAATATGAACCTCCCATTGGGCCTTCCATAGGGAAAGCTGTGACTACTCT
GAAATGGAACCTAGCATTATATCCTTGTAGGGTAGATTATAAATCATTTCCAGTTCATTTCTCTTAGAGGTGATTACCTCTAGCCATCAG
CCTTACTCCATCCCATGTTTGGTATGCAATTTGAGCCACAAGGCTCGTATCGCCAACAGCTATATACATTTTGTTCCATTTTTCTGTCTT
ACAGAGCCATGATAGAACTGTGGTTAGTGAGTTAAAATTCCTGGAGTAACTACTGTTTTTCTCCTTTGAAACTTAGGTTTCTAAAGTTGC
ACCTAAGGAATCTGTCACATTTTCTGTTGAATCATGGTTTTTGTTTTTGTTTTTAACAGATATTCCTTCTGATACGGACTTGAAAATTAG
TGTATGGTGACCTGTGTTTAAAAAAAAAAGTACAATACAACTACATATAGCTATATAGCTTAATGAGACTTCCACCCCCCCCCTTTTTTT
TTTTGGTTTGTTGTTGTTGTAGTAGTCTGGTGCTGGCCACATTTAAGTCTTAAAAATTTTTAAATTTTGTTGTTGATGTTTGTAGACAGC
CCTGTTGTTGAAATCATGGCTTTATTCATTTTATTTATTTTTTAAACTTGCCTGAATTTGTTCTAAAGGAATATTTAAGAGACATAATTT
TCTTCTCTTTACCATAACATTACACAAAACTTTTTCCTAAAACACGGTTGTGAGGTACTGATGAGGTGTAAGTGGAGCTGTTAAAAACAG
CAGTGCTGTATTGCAGTTATGTATATTCGTGTACAGTATGTTTAGATCCCAGGTAAACATATTCTTTTCTGAGAGGATAAATACCTGCAT
TCAGATATTCCAGGTAAATATAATTGAGTCAGGGAGTAGTAAATCTGATGGAGAATTCACTTTGGGGAGGGGAAAAAGAATAGTATGCAA
GACCCTTATTGGCTTTTAATTATACCTGAAACCAAAATGGATATTTTTAGTCTCTCTGCATGTGAGATTTGGTGTAACAAGATAGAACTA
TAATATATACAGTATATGGAAGGATAGATATAGTGCTTTGTTCATTTTAATTGCAAAGCTGCCAAAATAGTTGAAGCTTAATTACTTGAC
TTGCCTTGATTTATAGGACTGGGGCTTGGAGAAAATGAGCAGATGTTCCTCTAAGACATCGATTACAGAAGCCTTATATACATGGATTTG
ATTTTGTATTTGTAGCTGAAAGTCACTGTTGTCTAAAACTAACTTTTCTAAGTTATCAAAACAACCTAATTTCTTTTCCAACAAGGAGAA
CTTAATGGCATGAAGGATTGTGTGACACATTGGAAAAGCCAGCTTACTGCCACTCTCTTCCTTTGGCCATTAGAGGGAGGTGTTGCCTTT
CATTGACGCTTAGAAGCAAATTGTTCACTTGTTAAGAAAAGTAAATCCTTAAAAAAAGAAAAGGAAAAAATTTAACCAATTTTTCTTAAT
ACCCAGAAGGAATTATACTCAATATTTCCCTAGTTAAGAAAAGAGGAGATAATGTTCGTCTAAAAAACTCCAACGTTGTAATTACAACTC
TACATTCATTTACTTACTTGACATACTGCCACAAAGTAGTTTTTGAGTTCATTAAAAATTCCAAAGGCATTAGTTGTTTTTTTTTTTTTT
AGTGTTTTGTTTTTTAGTTAACTTTTATAGACATTTTAGTAACTTGCTAAAGATTCAGGGGATTCTATGAAACCCCGAATTTAGAAACAT
CTGGTCTACCTCAGTTAAATGTTGACTGCTTAGAAATATAGCTGAAGTGATCACCACAGCCATAAAATTGTTTAAGAAAGATTTATATAA
TGTTTACAAATCTGGAATCAAGGATTTTAGCTGAAATCCTTTAAGAGATATTAGAGCAAGTATTTAATTCAGGTATTTTCAAGTTTTAAA
ACTTAACCTGTTTACCTACTAAAAATAAAATAGCTAGTTTTTTTCTGCATATAAAAGTTCATTGAAATGATATGCCCTTATTTGCAATAC
TTTTCCCATAAAGTTTTAAGTGTGAAAGAATTGTAATTTACTAGATATGTTTGGTATGGGATATTTTGTTAGGCAAGTTTTCTTTTTTCT
TCTTAAATTGCAATAGGCTTCCAAAAAGAGTATAATTGTTTCAGAACAAATTAACTCTTGGCATTATACGTCTCCCTTTTTCTTTACAGT
ATTAGTAAAAAGAAAAATTGTACACTTTCTGATTTTAACTTCACTAATGTAATTACTCTCTCAAGAAGCTTTTAAAATTTAAATTACCAT
CACACAACCTTTTTTATAGTAAAGCCAACATTTGTTCTCTCACCAAACCCCATGCCAAATTCATCATGAAGAAAGCTCAGCATAAGTAAT
TCAAATACTGCTTATAATTTTAGAGGGGGGTAGAATTTAGTAAATATTCCAGCCGGTCGTTTTATGCACAAGGCTTCAGTCAGAACATAG
AAAAAAAAAACATTCTGTGAATGAAATATTGTATGTTCAGATTTTATAAAAGACATTTTTAAAAGCCCAATTTACAGCCGTATATTTTCT
TATGATGTAATTTATGAAAAAGATGTCTGTACTAACAGGTGCTGTAACACTACTGTTGTTGGATTTTATTGTTTGGTGATAAATGTATAC
AATATTTCTAAGGGAAACTATGTACTGTGATGTAAAAGTCTGGGCAAAATGTATATAATCCTGTATATAATTATGTATTTGATTATAATT
ACTGATTGTAAAGATTTAATAAAATATGTAAATATTCCAGTTTAGTTTTAATTTGAATTTTTAGAATCACTGTGCATATCCTCATACTTT
TATGTCTTGATGTTTATCACTCTGTTTTCCTTTTTTTTTTAAACTCATTTTATCCTCCGGGGATTGAATTCTGGGGACATTTTAGGCTGT
AGAAACCCAAGCTTGTGGGCTAAAGTAAGGATTTTGTTCTAAGAAATCACTGAAAGTTTTTCAACAAGTCAGTAGCATGCACAAAGGTAA

>In-frame_ENST00000338465_ENST00000318130_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(amino acids)=430AA_start in transcript=676_stop in transcript=1968
MQSIKTDFLQTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEIL
KKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRG
FVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEG
SIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPESLSLADMDNAASISPSE

--------------------------------------------------------------
>In-frame_ENST00000338465_ENST00000367512_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(transcript)=2257nt_BP=706nt
CATCAGCCGCTCTCCCTGACTAGGGGTAGCTAGCGGCCTCCCTCCTTTGGGTTCGGTATCCCTACTTCCATTACCCTCGGCTCCTCCCAC
TCCTCGCGGGCTCCGTGCTTTCCGCGGGTCTGTCCGGGGGCTCCGGACCCTCGGCGCAGCTGAGTTGATGGCTTCCGGAGAACTGGCATA
GCTGCAGAATATGAGTAGTGTCCCAAGAAGAGTGCTTTGCCTTTGGCACAAGGATCAGAATAAAGGTGAATTGCTATTACATAGGGTTTT
TCGGTAAAAGTCACTGAAAATTATTTGCCATACAGTAACCAGAGACCTCCAACTAGGGGCCCCCAAACTGTATCCTGCCTGTAGCCAGAA
GCAATTTTTAAAGAAAATATGTCTCCTCTGAAGATACATGGTCCTATCAGAATTCGAAGTATGCAGACTGGGATTACAAAGTGGAAAGAA
GGATCCTTTGAAATTGTAGAAAAAGAGAATAAAGTCAGCCTAGTAGTTCACTACAATACTGGAGGAATTCCAAGGATATTTCAGCTAAGT
CATAACATTAAAAATGTGGTGCTTCGACCCAGTGGAGCGAAACAAAGCCGCCTAATGTTAACTCTGCAAGATAACAGCTTCTTGTCTATT
GACAAAGTACCAAGTAAGGATGCAGAGGAAATGAGGTTGTTTCTAGATGCAGTCCATCAAAACAGACTTCCTGCAGACCTCGGAATATAC
AGAACTGGATGACAGTAACTTCGATTGGACTTGTCCAAATACTCAGATCCTCTTTCCTAATGACCCATTGTATGCTCAAAGTATTCGTGA
GCCCTTGAAAAATGTGGTGGATAAGAGCTGTCCTAGAGGCATCATCAGAGTAGAGGAGAGTTTCAGGAGTGGAGCTAAACCCCCTCTGAG
AGCCAGAGATTTCATGGCCACTAACCCTGAGCATTTAGAAATCCTGAAGAAGATGGGGGTGAGTTTGATTCACCTCAAAGATGGGAGAGT
CCAGTTGGTCCAACATGCAATCCAAGCTGCTAGTTCAATCGACGCTGAAGATGGGTTGAGGTTCATGCAGGAGATGATTGAATTGTCAAG
TCAGCAACAAAAAGAACAGCAGCTGCCTCCACGAGCTGTACAAATTGTTTCCCACCCATTTTTTGGCAGGGTAGTATTGACTGCTGGACC
AGCTCAGTTTGGGCTGGATCTGTCTAAACATAAAGAGACAAGAGGATTTGTTGCAAGCAGTAAACCATCCAATGGTTGTTCAGAGCTTAC
TAACCCAGAGGCAGTGATGGGAAAAATCGCACTGATACAAAGAGGACAGTGCATGTTTGCAGAAAAGGCACGCAACATCCAGAATGCTGG
AGCCATTGGTGGCATTGTTATTGATGACAATGAGGGGAGCAGCAGTGATACTGCCCCTCTGTTCCAGATGGCAGGTGATGGAAAGGATAC
AGATGACATCAAGATCCCCATGCTGTTCTTATTCAGCAAAGAAGGAAGTATCATACTGGATGCCATCCGGGAATATGAGGAGGTAGAAGT
GCTCCTCTCTGATAAAGCAAAAGATCGAGCAGCAATATTAAAAGGTAAAATGATTCCAAGCTACATTATTAATAGTAATCCTGAAATGGA
AAATGAAGAACAACCATCCTCTGAAAATGATTCTCAGAATCAGAGTGGTGAACAGATTTCATCAAGTTCTCAGGAGGTTGATTTGGTTGA
TCAAGAGTCTTCTGAGGAAAATTCTCTAAATTCTCACCCAGAATCATTATCTCTAGCAGATATGGACAATGCTGCAAGCATTTCCCCTTC
TGAACAGACTTCTAATCCCACAGAAAACCATGAGACTACAAATCTTAATGGTGAATGTACAGATTTAGATAACCAGCTTCAAGAACAATC
AGAAACTGAGGAAGATTCCAATCCTAATGTTAGCTGGGGTAAAAAGGTCCAGCCTATAGACTCCATATTAGCAGACTGGAATGAAGATAT
AGAAGCATTTGAAATGATGGAGAAGGATGAGCTATGACTTGCTAAACAATCTGTTGGTAGGTATTTAAAAAGAAAAGGTAAACTGTGTGT
GGTTAATAGACATCCTAATACTAAGCAGGCTTTCTAATGGGAGGCTTTAAGTATGGTGATGAACAACCACGTTCTGACTGGCGTAGTTAT
CGTAGGAATCTGGAGCATGCTGTGTTAGAATTGACCTTGTTTAAAACTGTCCCATCAAAAATGGAAATCCACAGTTCCCCCTTCAAATGC

>In-frame_ENST00000338465_ENST00000367512_ERR315469_USP37_chr2_219418276_-_EDEM3_chr1_184681011_length(amino acids)=446AA_start in transcript=676_stop in transcript=2016
MQSIKTDFLQTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEIL
KKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRG
FVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEG
SIILDAIREYEEVEVLLSDKAKDRAAILKGKMIPSYIINSNPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPES

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USP37-EDEM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP37-EDEM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP37-EDEM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource