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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP46-SCFD2 (FusionGDB2 ID:96842)

Fusion Gene Summary for USP46-SCFD2

check button Fusion gene summary
Fusion gene informationFusion gene name: USP46-SCFD2
Fusion gene ID: 96842
HgeneTgene
Gene symbol

USP46

SCFD2

Gene ID

64854

152579

Gene nameubiquitin specific peptidase 46sec1 family domain containing 2
Synonyms-STXBP1L1
Cytomap

4q12

4q12

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 46deubiquitinating enzyme 46ubiquitin thioesterase 46ubiquitin thiolesterase 46ubiquitin-specific-processing protease 46sec1 family domain-containing protein 2syntaxin binding protein 1-like 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000441222, ENST00000451218, 
ENST00000508499, ENST00000504078, 
ENST00000401642, ENST00000388940, 
Fusion gene scores* DoF score3 X 5 X 4=6015 X 10 X 11=1650
# samples 620
** MAII scorelog2(6/60*10)=0log2(20/1650*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP46 [Title/Abstract] AND SCFD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP46(53525281)-SCFD2(53752033), # samples:1
USP46(53525281)-SCFD2(53787037), # samples:1
USP46(53494117)-SCFD2(54140168), # samples:1
USP46(53525282)-SCFD2(53752033), # samples:1
USP46(53525282)-SCFD2(53787037), # samples:1
Anticipated loss of major functional domain due to fusion event.USP46-SCFD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
USP46-SCFD2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP46

GO:0016579

protein deubiquitination

14715245|19075014


check buttonFusion gene breakpoints across USP46 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SCFD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-CS-6665USP46chr4

53525281

-SCFD2chr4

53752033

-
ChimerDB4OVTCGA-13-0766USP46chr4

53525281

-SCFD2chr4

53787037

-
ChimerDB4GBMTCGA-06-0174-01AUSP46chr4

53494117

-SCFD2chr4

54140168

-
ChimerDB4LGGTCGA-CS-6665USP46chr4

53525282

-SCFD2chr4

53752033

-
ChimerDB4OVTCGA-13-0766-01AUSP46chr4

53525282

-SCFD2chr4

53787037

-


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Fusion Gene ORF analysis for USP46-SCFD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000441222ENST00000401642USP46chr4

53525281

-SCFD2chr4

53752033

-
In-frameENST00000441222ENST00000388940USP46chr4

53525281

-SCFD2chr4

53752033

-
In-frameENST00000451218ENST00000401642USP46chr4

53525281

-SCFD2chr4

53752033

-
In-frameENST00000451218ENST00000388940USP46chr4

53525281

-SCFD2chr4

53752033

-
intron-3CDSENST00000508499ENST00000401642USP46chr4

53525281

-SCFD2chr4

53752033

-
intron-3CDSENST00000508499ENST00000388940USP46chr4

53525281

-SCFD2chr4

53752033

-
intron-3CDSENST00000504078ENST00000401642USP46chr4

53525281

-SCFD2chr4

53752033

-
intron-3CDSENST00000504078ENST00000388940USP46chr4

53525281

-SCFD2chr4

53752033

-
Frame-shiftENST00000441222ENST00000401642USP46chr4

53525281

-SCFD2chr4

53787037

-
Frame-shiftENST00000441222ENST00000388940USP46chr4

53525281

-SCFD2chr4

53787037

-
Frame-shiftENST00000451218ENST00000401642USP46chr4

53525281

-SCFD2chr4

53787037

-
Frame-shiftENST00000451218ENST00000388940USP46chr4

53525281

-SCFD2chr4

53787037

-
intron-3CDSENST00000508499ENST00000401642USP46chr4

53525281

-SCFD2chr4

53787037

-
intron-3CDSENST00000508499ENST00000388940USP46chr4

53525281

-SCFD2chr4

53787037

-
intron-3CDSENST00000504078ENST00000401642USP46chr4

53525281

-SCFD2chr4

53787037

-
intron-3CDSENST00000504078ENST00000388940USP46chr4

53525281

-SCFD2chr4

53787037

-
In-frameENST00000441222ENST00000401642USP46chr4

53494117

-SCFD2chr4

54140168

-
In-frameENST00000441222ENST00000388940USP46chr4

53494117

-SCFD2chr4

54140168

-
In-frameENST00000451218ENST00000401642USP46chr4

53494117

-SCFD2chr4

54140168

-
In-frameENST00000451218ENST00000388940USP46chr4

53494117

-SCFD2chr4

54140168

-
In-frameENST00000508499ENST00000401642USP46chr4

53494117

-SCFD2chr4

54140168

-
In-frameENST00000508499ENST00000388940USP46chr4

53494117

-SCFD2chr4

54140168

-
intron-3CDSENST00000504078ENST00000401642USP46chr4

53494117

-SCFD2chr4

54140168

-
intron-3CDSENST00000504078ENST00000388940USP46chr4

53494117

-SCFD2chr4

54140168

-
In-frameENST00000441222ENST00000401642USP46chr4

53525282

-SCFD2chr4

53752033

-
In-frameENST00000441222ENST00000388940USP46chr4

53525282

-SCFD2chr4

53752033

-
In-frameENST00000451218ENST00000401642USP46chr4

53525282

-SCFD2chr4

53752033

-
In-frameENST00000451218ENST00000388940USP46chr4

53525282

-SCFD2chr4

53752033

-
intron-3CDSENST00000508499ENST00000401642USP46chr4

53525282

-SCFD2chr4

53752033

-
intron-3CDSENST00000508499ENST00000388940USP46chr4

53525282

-SCFD2chr4

53752033

-
intron-3CDSENST00000504078ENST00000401642USP46chr4

53525282

-SCFD2chr4

53752033

-
intron-3CDSENST00000504078ENST00000388940USP46chr4

53525282

-SCFD2chr4

53752033

-
Frame-shiftENST00000441222ENST00000401642USP46chr4

53525282

-SCFD2chr4

53787037

-
Frame-shiftENST00000441222ENST00000388940USP46chr4

53525282

-SCFD2chr4

53787037

-
Frame-shiftENST00000451218ENST00000401642USP46chr4

53525282

-SCFD2chr4

53787037

-
Frame-shiftENST00000451218ENST00000388940USP46chr4

53525282

-SCFD2chr4

53787037

-
intron-3CDSENST00000508499ENST00000401642USP46chr4

53525282

-SCFD2chr4

53787037

-
intron-3CDSENST00000508499ENST00000388940USP46chr4

53525282

-SCFD2chr4

53787037

-
intron-3CDSENST00000504078ENST00000401642USP46chr4

53525282

-SCFD2chr4

53787037

-
intron-3CDSENST00000504078ENST00000388940USP46chr4

53525282

-SCFD2chr4

53787037

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000441222USP46chr453525281-ENST00000401642SCFD2chr453752033-14212211281820153
ENST00000441222USP46chr453525281-ENST00000388940SCFD2chr453752033-61522118543382
ENST00000451218USP46chr453525281-ENST00000401642SCFD2chr453752033-13761761236775153
ENST00000451218USP46chr453525281-ENST00000388940SCFD2chr453752033-57017614038882
ENST00000441222USP46chr453494117-ENST00000401642SCFD2chr454140168-24235161851435416
ENST00000441222USP46chr453494117-ENST00000388940SCFD2chr454140168-14825161851300371
ENST00000451218USP46chr453494117-ENST00000401642SCFD2chr454140168-22973901401309389
ENST00000451218USP46chr453494117-ENST00000388940SCFD2chr454140168-13563901401174344
ENST00000508499USP46chr453494117-ENST00000401642SCFD2chr454140168-24975902801509409
ENST00000508499USP46chr453494117-ENST00000388940SCFD2chr454140168-15565902801374364
ENST00000441222USP46chr453525282-ENST00000401642SCFD2chr453752033-14212211281820153
ENST00000441222USP46chr453525282-ENST00000388940SCFD2chr453752033-61522118543382
ENST00000451218USP46chr453525282-ENST00000401642SCFD2chr453752033-13761761236775153
ENST00000451218USP46chr453525282-ENST00000388940SCFD2chr453752033-57017614038882

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441222ENST00000401642USP46chr453525281-SCFD2chr453752033-0.098274660.9017253
ENST00000441222ENST00000388940USP46chr453525281-SCFD2chr453752033-0.0494072180.9505928
ENST00000451218ENST00000401642USP46chr453525281-SCFD2chr453752033-0.142628430.8573716
ENST00000451218ENST00000388940USP46chr453525281-SCFD2chr453752033-0.05534340.94465655
ENST00000441222ENST00000401642USP46chr453494117-SCFD2chr454140168-0.0008895090.9991105
ENST00000441222ENST00000388940USP46chr453494117-SCFD2chr454140168-0.0058059110.9941941
ENST00000451218ENST00000401642USP46chr453494117-SCFD2chr454140168-0.0007232170.9992768
ENST00000451218ENST00000388940USP46chr453494117-SCFD2chr454140168-0.0025523340.9974477
ENST00000508499ENST00000401642USP46chr453494117-SCFD2chr454140168-0.0011568590.9988431
ENST00000508499ENST00000388940USP46chr453494117-SCFD2chr454140168-0.0045890890.99541086
ENST00000441222ENST00000401642USP46chr453525282-SCFD2chr453752033-0.098274660.9017253
ENST00000441222ENST00000388940USP46chr453525282-SCFD2chr453752033-0.0494072180.9505928
ENST00000451218ENST00000401642USP46chr453525282-SCFD2chr453752033-0.142628430.8573716
ENST00000451218ENST00000388940USP46chr453525282-SCFD2chr453752033-0.05534340.94465655

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Fusion Genomic Features for USP46-SCFD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP46-SCFD2


check button Go to

FGviewer for the breakpoints of chr4:53525281-chr4:53752033

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP46chr4:53494117chr4:54140168ENST00000441222-3935_365110.33333333333333367.0DomainNote=USP
HgeneUSP46chr4:53494117chr4:54140168ENST00000508499-3935_365103.33333333333333360.0DomainNote=USP
HgeneUSP46chr4:53525281chr4:53752033ENST00000441222-1935_36512.0367.0DomainNote=USP
HgeneUSP46chr4:53525281chr4:53752033ENST00000508499-1935_3650360.0DomainNote=USP
HgeneUSP46chr4:53525282chr4:53752033ENST00000441222-1935_36512.0367.0DomainNote=USP
HgeneUSP46chr4:53525282chr4:53752033ENST00000508499-1935_3650360.0DomainNote=USP
TgeneSCFD2chr4:53494117chr4:54140168ENST0000038894028120_124378.3333333333333640.0Compositional biasNote=Poly-Ala
TgeneSCFD2chr4:53494117chr4:54140168ENST0000040164229120_124378.3333333333333685.0Compositional biasNote=Poly-Ala
TgeneSCFD2chr4:53525281chr4:53752033ENST0000038894058120_124569.0640.0Compositional biasNote=Poly-Ala
TgeneSCFD2chr4:53525281chr4:53752033ENST0000040164269120_124614.0685.0Compositional biasNote=Poly-Ala
TgeneSCFD2chr4:53525282chr4:53752033ENST0000038894058120_124569.0640.0Compositional biasNote=Poly-Ala
TgeneSCFD2chr4:53525282chr4:53752033ENST0000040164269120_124614.0685.0Compositional biasNote=Poly-Ala


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Fusion Gene Sequence for USP46-SCFD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000441222_ENST00000401642_TCGA-CS-6665_USP46_chr4_53525281_-_SCFD2_chr4_53752033_length(transcript)=1421nt_BP=221nt
CGCTCCCTCCCCGCCCTCCCCGCGCCGCCGCCTCCTCCTCCCGGCCTCCCTCTCCCAGCCAAACTGAAAGCCGGACCCCAGGCCGCCGCG
CTGCCGCCCGGCCTCCCCGCCAGCGCGCCACCATGGGCAGTCCCGGTTTCCCCTTGTAAAGATGGCGGTGAGGGATCGCTGCAACCTTTA
GACTAATGACTGTCCGAAACATCGCCTCCATCTGTAATATGGTGAGCCGGCCTCATCCTAGTGACTACCCCCTCCTGATCCTCTTTGTGG
TAGGTGGGGTCACAGTCTCTGAAGTGAAAATGGTCAAAGATCTTGTGGCATCGTTGAAGCCAGGAACCCAGGTAATCGTGCTGTCCACAC
GACTCCTGAAGCCACTTAACATTCCTGAGCTGTTATTTGCAACTGACCGACTGCATCCAGACCTTGGCTTCTGAGCATCCGCTAAGAAGA
TAAGACCTACTCAAGCTGGAAATGCCGATGCAATTTTCTGCCACCACTCCAAATACTCCTCCACAACCAGCGTCCCTGTCACTAATTGCG
AGAATGATGGAATTCTGCCTGAAGGGTCTTGATACCTACTCAGTGAGGTACTTTGCTTGGATTGCTGTGATTCTTAAAAAAAAAAAAAAA
AAGTTTTTTTATTTTCCTGAAGGCGACAGTCTGTCTTTTGGCGAGTCCAATTAGTGATCGTTTCCATTTATCCTTAACCCTCTGTTTGTG
ATCTTCCTGATTCCACCTACAAGTTCATTAGTTCTAAATAAAAGCCTGTTGGCAAGTGTTGGTAGATTACAACTCTTTTTATTTGAAGTT
GCTCGAGAAGTTAGACATGCTTTAGAATTATGAGTGTGGGGAAAATTTGATGTTCCTTAGGATTATATAACTGAGGAGGGAACATTGCAA
ATAGGGTCTGAGGCTTTGTTTCTCTCTTGCTCTGAAACATTTCTGAAAAGGCAAGGAAGGGAGGGGTAGTGTCTGGGGCAGTGCTGGTAG
CCTGCATGTGTTGTAAATCATCCTGCCATAACAAAGGACTGCATTGTTCTAGCTGGCCCACTGGGCAGGTCTGCCAGGCTACTTGGAACT
GTAGTGGGAAGGTGGTTGATTGGAGGGTTATCTGTATATAAAAGGTTTTCTCCCCTCCAAAGAAAGACTCCAGTACAAGATACCTGGTCC
CAGGGAGTCTAAATTGTAACAGCAACCCCTGTGGACTTTGTGGGTATGAGTTTTGATTGAAATATAAAGCTTTCTTTTCTGTAAGTTTAA
GTTTTCCATCTGACCATAGCAGAAAAACCTAGACCCACCTAGTGAAACTTTGTAAGAACTCCAGGGCAAAAACGAACCACTTGCAACCCA

>In-frame_ENST00000441222_ENST00000401642_TCGA-CS-6665_USP46_chr4_53525281_-_SCFD2_chr4_53752033_length(amino acids)=153AA_start in transcript=1281_stop in transcript=820
MLWSDGKLKLTEKKALYFNQNSYPQSPQGLLLQFRLPGTRYLVLESFFGGEKTFYIQITLQSTTFPLQFQVAWQTCPVGQLEQCSPLLWQ

--------------------------------------------------------------
>In-frame_ENST00000441222_ENST00000388940_TCGA-CS-6665_USP46_chr4_53525281_-_SCFD2_chr4_53752033_length(transcript)=615nt_BP=221nt
CGCTCCCTCCCCGCCCTCCCCGCGCCGCCGCCTCCTCCTCCCGGCCTCCCTCTCCCAGCCAAACTGAAAGCCGGACCCCAGGCCGCCGCG
CTGCCGCCCGGCCTCCCCGCCAGCGCGCCACCATGGGCAGTCCCGGTTTCCCCTTGTAAAGATGGCGGTGAGGGATCGCTGCAACCTTTA
GACTAATGACTGTCCGAAACATCGCCTCCATCTGTAATATGGTGAGCCGGCCTCATCCTAGTGACTACCCCCTCCTGATCCTCTTTGTGG
TAGGTGGGGTCACAGTCTCTGAAGTGAAAATGGTCAAAGATCTTGTGGCATCGTTGAAGCCAGGAACCCAGGTAATCGTGCTGTCCACAC
GACTCCTGAAGCCACTTAACATTCCTGAGCTGTTATTTGCAACTGACCGACTGCATCCAGACCTTGGCTTCTGAGCATCCGCTAAGAAGA
TAAGACCTACTCAAGCTGGAAATGCCGATGCAATTTTCTGCCACCACTCCAAATACTCCTCCACAACCAGCGTCCCTGTCACTAATTGCG

>In-frame_ENST00000441222_ENST00000388940_TCGA-CS-6665_USP46_chr4_53525281_-_SCFD2_chr4_53752033_length(amino acids)=82AA_start in transcript=185_stop in transcript=433

--------------------------------------------------------------
>In-frame_ENST00000451218_ENST00000401642_TCGA-CS-6665_USP46_chr4_53525281_-_SCFD2_chr4_53752033_length(transcript)=1376nt_BP=176nt
CTCCCTCTCCCAGCCAAACTGAAAGCCGGACCCCAGGCCGCCGCGCTGCCGCCCGGCCTCCCCGCCAGCGCGCCACCATGGGCAGTCCCG
GTTTCCCCTTGTAAAGATGGCGGTGAGGGATCGCTGCAACCTTTAGACTAATGACTGTCCGAAACATCGCCTCCATCTGTAATATGGTGA
GCCGGCCTCATCCTAGTGACTACCCCCTCCTGATCCTCTTTGTGGTAGGTGGGGTCACAGTCTCTGAAGTGAAAATGGTCAAAGATCTTG
TGGCATCGTTGAAGCCAGGAACCCAGGTAATCGTGCTGTCCACACGACTCCTGAAGCCACTTAACATTCCTGAGCTGTTATTTGCAACTG
ACCGACTGCATCCAGACCTTGGCTTCTGAGCATCCGCTAAGAAGATAAGACCTACTCAAGCTGGAAATGCCGATGCAATTTTCTGCCACC
ACTCCAAATACTCCTCCACAACCAGCGTCCCTGTCACTAATTGCGAGAATGATGGAATTCTGCCTGAAGGGTCTTGATACCTACTCAGTG
AGGTACTTTGCTTGGATTGCTGTGATTCTTAAAAAAAAAAAAAAAAAGTTTTTTTATTTTCCTGAAGGCGACAGTCTGTCTTTTGGCGAG
TCCAATTAGTGATCGTTTCCATTTATCCTTAACCCTCTGTTTGTGATCTTCCTGATTCCACCTACAAGTTCATTAGTTCTAAATAAAAGC
CTGTTGGCAAGTGTTGGTAGATTACAACTCTTTTTATTTGAAGTTGCTCGAGAAGTTAGACATGCTTTAGAATTATGAGTGTGGGGAAAA
TTTGATGTTCCTTAGGATTATATAACTGAGGAGGGAACATTGCAAATAGGGTCTGAGGCTTTGTTTCTCTCTTGCTCTGAAACATTTCTG
AAAAGGCAAGGAAGGGAGGGGTAGTGTCTGGGGCAGTGCTGGTAGCCTGCATGTGTTGTAAATCATCCTGCCATAACAAAGGACTGCATT
GTTCTAGCTGGCCCACTGGGCAGGTCTGCCAGGCTACTTGGAACTGTAGTGGGAAGGTGGTTGATTGGAGGGTTATCTGTATATAAAAGG
TTTTCTCCCCTCCAAAGAAAGACTCCAGTACAAGATACCTGGTCCCAGGGAGTCTAAATTGTAACAGCAACCCCTGTGGACTTTGTGGGT
ATGAGTTTTGATTGAAATATAAAGCTTTCTTTTCTGTAAGTTTAAGTTTTCCATCTGACCATAGCAGAAAAACCTAGACCCACCTAGTGA
AACTTTGTAAGAACTCCAGGGCAAAAACGAACCACTTGCAACCCACATGTTTGTAGGTGTATGGTCGATGGAAGTTTCTGGCATCCATGT

>In-frame_ENST00000451218_ENST00000401642_TCGA-CS-6665_USP46_chr4_53525281_-_SCFD2_chr4_53752033_length(amino acids)=153AA_start in transcript=1236_stop in transcript=775
MLWSDGKLKLTEKKALYFNQNSYPQSPQGLLLQFRLPGTRYLVLESFFGGEKTFYIQITLQSTTFPLQFQVAWQTCPVGQLEQCSPLLWQ

--------------------------------------------------------------
>In-frame_ENST00000451218_ENST00000388940_TCGA-CS-6665_USP46_chr4_53525281_-_SCFD2_chr4_53752033_length(transcript)=570nt_BP=176nt
CTCCCTCTCCCAGCCAAACTGAAAGCCGGACCCCAGGCCGCCGCGCTGCCGCCCGGCCTCCCCGCCAGCGCGCCACCATGGGCAGTCCCG
GTTTCCCCTTGTAAAGATGGCGGTGAGGGATCGCTGCAACCTTTAGACTAATGACTGTCCGAAACATCGCCTCCATCTGTAATATGGTGA
GCCGGCCTCATCCTAGTGACTACCCCCTCCTGATCCTCTTTGTGGTAGGTGGGGTCACAGTCTCTGAAGTGAAAATGGTCAAAGATCTTG
TGGCATCGTTGAAGCCAGGAACCCAGGTAATCGTGCTGTCCACACGACTCCTGAAGCCACTTAACATTCCTGAGCTGTTATTTGCAACTG
ACCGACTGCATCCAGACCTTGGCTTCTGAGCATCCGCTAAGAAGATAAGACCTACTCAAGCTGGAAATGCCGATGCAATTTTCTGCCACC
ACTCCAAATACTCCTCCACAACCAGCGTCCCTGTCACTAATTGCGAGAATGATGGAATTCTGCCTGAAGGGTCTTGATACCTACTCAGTG

>In-frame_ENST00000451218_ENST00000388940_TCGA-CS-6665_USP46_chr4_53525281_-_SCFD2_chr4_53752033_length(amino acids)=82AA_start in transcript=140_stop in transcript=388

--------------------------------------------------------------
>In-frame_ENST00000441222_ENST00000401642_TCGA-06-0174-01A_USP46_chr4_53494117_-_SCFD2_chr4_54140168_length(transcript)=2423nt_BP=516nt
CGCTCCCTCCCCGCCCTCCCCGCGCCGCCGCCTCCTCCTCCCGGCCTCCCTCTCCCAGCCAAACTGAAAGCCGGACCCCAGGCCGCCGCG
CTGCCGCCCGGCCTCCCCGCCAGCGCGCCACCATGGGCAGTCCCGGTTTCCCCTTGTAAAGATGGCGGTGAGGGATCGCTGCAACCTTTA
GACTAATGACTGTCCGAAACATCGCCTCCATCTGTAATATGGGCACCAATGCCTCTGCTCTGGAAAAAGACATTGGTCCAGAGCAGTTTC
CAATCAATGAACACTATTTCGGATTGGTCAATTTTGGAAACACATGCTACTGTAACTCCGTGCTTCAGGCATTGTACTTCTGCCGTCCAT
TCCGGGAGAATGTGTTGGCATACAAGGCCCAGCAAAAGAAGAAGGAAAACTTGCTGACGTGCCTGGCGGACCTTTTCCACAGCATTGCCA
CACAGAAGAAGAAGGTTGGCGTCATCCCACCAAAGAAGTTCATTTCAAGGCTGAGAAAAGAGAATGGGAGAGTCACACCGGGACAGCTCA
TGTCCTATATTCAGCTCTTCAAGAACAACCTCAAAGCTCTAATGAATCATTGTGGCCTCCTCCAGCTTGGACTGGCCACAGCTCAAACGT
TGAAACACCCACAGACTGCCAAGTGGGACAACTTTCTGGCTTTTGAAAGGCTCCTTCTTCAGAGCATTGGGGAGTCAGCAATGTCCGTTG
TGTTAAATCAGCTGCTGCCCATGATTAAGCCTGTAACCCAGAGAACCAACGAGGACTACAGCCCTGAGGAACTGCTGATCCTTCTCATAT
ATATTTATTCTGTCACTGGAGAGCTCACGGTAGACAAAGACCTGTGTGAAGCAGAAGAAAAAGTCAAGAAAGCATTGGCTCAGGTCTTCT
GTGAGGAATCTGGATTGTCACCTTTGCTGCAAAAAATTACGGACTGGGACTCTTCAATTAATCTGACATTTCACAAATCCAAAATTGCCG
TGGATGAACTCTTTACTTCACTTCGGGATATTGCTGGAGCTCGGAGTCTCCTGAAACAGTTTAAGTCTGTATATGTTCCTGGAAATCATA
CCCACCAGGCATCTTATAAGCCATTGTTGAAGCAAGTTGTGGAGGAAATATTTCATCCCGAGAGGCCAGATTCCGTTGATATTGAACACA
TGTCTTCAGGCCTCACTGATCTCCTTAAAACTGGATTTAGCATGTTCATGAAGGTGAGCCGGCCTCATCCTAGTGACTACCCCCTCCTGA
TCCTCTTTGTGGTAGGTGGGGTCACAGTCTCTGAAGTGAAAATGGTCAAAGATCTTGTGGCATCGTTGAAGCCAGGAACCCAGGTAATCG
TGCTGTCCACACGACTCCTGAAGCCACTTAACATTCCTGAGCTGTTATTTGCAACTGACCGACTGCATCCAGACCTTGGCTTCTGAGCAT
CCGCTAAGAAGATAAGACCTACTCAAGCTGGAAATGCCGATGCAATTTTCTGCCACCACTCCAAATACTCCTCCACAACCAGCGTCCCTG
TCACTAATTGCGAGAATGATGGAATTCTGCCTGAAGGGTCTTGATACCTACTCAGTGAGGTACTTTGCTTGGATTGCTGTGATTCTTAAA
AAAAAAAAAAAAAAGTTTTTTTATTTTCCTGAAGGCGACAGTCTGTCTTTTGGCGAGTCCAATTAGTGATCGTTTCCATTTATCCTTAAC
CCTCTGTTTGTGATCTTCCTGATTCCACCTACAAGTTCATTAGTTCTAAATAAAAGCCTGTTGGCAAGTGTTGGTAGATTACAACTCTTT
TTATTTGAAGTTGCTCGAGAAGTTAGACATGCTTTAGAATTATGAGTGTGGGGAAAATTTGATGTTCCTTAGGATTATATAACTGAGGAG
GGAACATTGCAAATAGGGTCTGAGGCTTTGTTTCTCTCTTGCTCTGAAACATTTCTGAAAAGGCAAGGAAGGGAGGGGTAGTGTCTGGGG
CAGTGCTGGTAGCCTGCATGTGTTGTAAATCATCCTGCCATAACAAAGGACTGCATTGTTCTAGCTGGCCCACTGGGCAGGTCTGCCAGG
CTACTTGGAACTGTAGTGGGAAGGTGGTTGATTGGAGGGTTATCTGTATATAAAAGGTTTTCTCCCCTCCAAAGAAAGACTCCAGTACAA
GATACCTGGTCCCAGGGAGTCTAAATTGTAACAGCAACCCCTGTGGACTTTGTGGGTATGAGTTTTGATTGAAATATAAAGCTTTCTTTT
CTGTAAGTTTAAGTTTTCCATCTGACCATAGCAGAAAAACCTAGACCCACCTAGTGAAACTTTGTAAGAACTCCAGGGCAAAAACGAACC

>In-frame_ENST00000441222_ENST00000401642_TCGA-06-0174-01A_USP46_chr4_53494117_-_SCFD2_chr4_54140168_length(amino acids)=416AA_start in transcript=185_stop in transcript=1435
MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQ
KKKVGVIPPKKFISRLRKENGRVTPGQLMSYIQLFKNNLKALMNHCGLLQLGLATAQTLKHPQTAKWDNFLAFERLLLQSIGESAMSVVL
NQLLPMIKPVTQRTNEDYSPEELLILLIYIYSVTGELTVDKDLCEAEEKVKKALAQVFCEESGLSPLLQKITDWDSSINLTFHKSKIAVD
ELFTSLRDIAGARSLLKQFKSVYVPGNHTHQASYKPLLKQVVEEIFHPERPDSVDIEHMSSGLTDLLKTGFSMFMKVSRPHPSDYPLLIL

--------------------------------------------------------------
>In-frame_ENST00000441222_ENST00000388940_TCGA-06-0174-01A_USP46_chr4_53494117_-_SCFD2_chr4_54140168_length(transcript)=1482nt_BP=516nt
CGCTCCCTCCCCGCCCTCCCCGCGCCGCCGCCTCCTCCTCCCGGCCTCCCTCTCCCAGCCAAACTGAAAGCCGGACCCCAGGCCGCCGCG
CTGCCGCCCGGCCTCCCCGCCAGCGCGCCACCATGGGCAGTCCCGGTTTCCCCTTGTAAAGATGGCGGTGAGGGATCGCTGCAACCTTTA
GACTAATGACTGTCCGAAACATCGCCTCCATCTGTAATATGGGCACCAATGCCTCTGCTCTGGAAAAAGACATTGGTCCAGAGCAGTTTC
CAATCAATGAACACTATTTCGGATTGGTCAATTTTGGAAACACATGCTACTGTAACTCCGTGCTTCAGGCATTGTACTTCTGCCGTCCAT
TCCGGGAGAATGTGTTGGCATACAAGGCCCAGCAAAAGAAGAAGGAAAACTTGCTGACGTGCCTGGCGGACCTTTTCCACAGCATTGCCA
CACAGAAGAAGAAGGTTGGCGTCATCCCACCAAAGAAGTTCATTTCAAGGCTGAGAAAAGAGAATGGGAGAGTCACACCGGGACAGCTCA
TGTCCTATATTCAGCTCTTCAAGAACAACCTCAAAGCTCTAATGAATCATTGTGGCCTCCTCCAGCTTGGACTGGCCACAGCTCAAACGT
TGAAACACCCACAGACTGCCAAGTGGGACAACTTTCTGGCTTTTGAAAGGCTCCTTCTTCAGAGCATTGGGGAGTCAGCAATGTCCGTTG
TGTTAAATCAGCTGCTGCCCATGATTAAGCCTGTAACCCAGAGAACCAACGAGGACTACAGCCCTGAGGAACTGCTGATCCTTCTCATAT
ATATTTATTCTGTCACTGGAGAGCTCACGGTAGACAAAGACCTGTGTGAAGCAGAAGAAAAAGTCAAGAAAGCATTGGCTCAGGTCTTCT
GTGAGGAATCTGGATTGTCACCTTTGCTGCAAAAAATTACGGACTGGGACTCTTCAATTAATCTGACATTTCACAAATCCAAAATTGCCG
TGGATGAACTCTTTACTTCACTTCGGGATATTGCTGGAGCTCGGAGTCTCCTGAAACAGTTTAAGTCTGTATATGTTCCTGGAAATCATA
CCCACCAGGTGAGCCGGCCTCATCCTAGTGACTACCCCCTCCTGATCCTCTTTGTGGTAGGTGGGGTCACAGTCTCTGAAGTGAAAATGG
TCAAAGATCTTGTGGCATCGTTGAAGCCAGGAACCCAGGTAATCGTGCTGTCCACACGACTCCTGAAGCCACTTAACATTCCTGAGCTGT
TATTTGCAACTGACCGACTGCATCCAGACCTTGGCTTCTGAGCATCCGCTAAGAAGATAAGACCTACTCAAGCTGGAAATGCCGATGCAA
TTTTCTGCCACCACTCCAAATACTCCTCCACAACCAGCGTCCCTGTCACTAATTGCGAGAATGATGGAATTCTGCCTGAAGGGTCTTGAT

>In-frame_ENST00000441222_ENST00000388940_TCGA-06-0174-01A_USP46_chr4_53494117_-_SCFD2_chr4_54140168_length(amino acids)=371AA_start in transcript=185_stop in transcript=1300
MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQ
KKKVGVIPPKKFISRLRKENGRVTPGQLMSYIQLFKNNLKALMNHCGLLQLGLATAQTLKHPQTAKWDNFLAFERLLLQSIGESAMSVVL
NQLLPMIKPVTQRTNEDYSPEELLILLIYIYSVTGELTVDKDLCEAEEKVKKALAQVFCEESGLSPLLQKITDWDSSINLTFHKSKIAVD
ELFTSLRDIAGARSLLKQFKSVYVPGNHTHQVSRPHPSDYPLLILFVVGGVTVSEVKMVKDLVASLKPGTQVIVLSTRLLKPLNIPELLF

--------------------------------------------------------------
>In-frame_ENST00000451218_ENST00000401642_TCGA-06-0174-01A_USP46_chr4_53494117_-_SCFD2_chr4_54140168_length(transcript)=2297nt_BP=390nt
CTCCCTCTCCCAGCCAAACTGAAAGCCGGACCCCAGGCCGCCGCGCTGCCGCCCGGCCTCCCCGCCAGCGCGCCACCATGGGCAGTCCCG
GTTTCCCCTTGTAAAGATGGCGGTGAGGGATCGCTGCAACCTTTAGACTAATGACTGTCCGAAACATCGCCTCCATCTGTAATATGTTTG
GAAACACATGCTACTGTAACTCCGTGCTTCAGGCATTGTACTTCTGCCGTCCATTCCGGGAGAATGTGTTGGCATACAAGGCCCAGCAAA
AGAAGAAGGAAAACTTGCTGACGTGCCTGGCGGACCTTTTCCACAGCATTGCCACACAGAAGAAGAAGGTTGGCGTCATCCCACCAAAGA
AGTTCATTTCAAGGCTGAGAAAAGAGAATGGGAGAGTCACACCGGGACAGCTCATGTCCTATATTCAGCTCTTCAAGAACAACCTCAAAG
CTCTAATGAATCATTGTGGCCTCCTCCAGCTTGGACTGGCCACAGCTCAAACGTTGAAACACCCACAGACTGCCAAGTGGGACAACTTTC
TGGCTTTTGAAAGGCTCCTTCTTCAGAGCATTGGGGAGTCAGCAATGTCCGTTGTGTTAAATCAGCTGCTGCCCATGATTAAGCCTGTAA
CCCAGAGAACCAACGAGGACTACAGCCCTGAGGAACTGCTGATCCTTCTCATATATATTTATTCTGTCACTGGAGAGCTCACGGTAGACA
AAGACCTGTGTGAAGCAGAAGAAAAAGTCAAGAAAGCATTGGCTCAGGTCTTCTGTGAGGAATCTGGATTGTCACCTTTGCTGCAAAAAA
TTACGGACTGGGACTCTTCAATTAATCTGACATTTCACAAATCCAAAATTGCCGTGGATGAACTCTTTACTTCACTTCGGGATATTGCTG
GAGCTCGGAGTCTCCTGAAACAGTTTAAGTCTGTATATGTTCCTGGAAATCATACCCACCAGGCATCTTATAAGCCATTGTTGAAGCAAG
TTGTGGAGGAAATATTTCATCCCGAGAGGCCAGATTCCGTTGATATTGAACACATGTCTTCAGGCCTCACTGATCTCCTTAAAACTGGAT
TTAGCATGTTCATGAAGGTGAGCCGGCCTCATCCTAGTGACTACCCCCTCCTGATCCTCTTTGTGGTAGGTGGGGTCACAGTCTCTGAAG
TGAAAATGGTCAAAGATCTTGTGGCATCGTTGAAGCCAGGAACCCAGGTAATCGTGCTGTCCACACGACTCCTGAAGCCACTTAACATTC
CTGAGCTGTTATTTGCAACTGACCGACTGCATCCAGACCTTGGCTTCTGAGCATCCGCTAAGAAGATAAGACCTACTCAAGCTGGAAATG
CCGATGCAATTTTCTGCCACCACTCCAAATACTCCTCCACAACCAGCGTCCCTGTCACTAATTGCGAGAATGATGGAATTCTGCCTGAAG
GGTCTTGATACCTACTCAGTGAGGTACTTTGCTTGGATTGCTGTGATTCTTAAAAAAAAAAAAAAAAAGTTTTTTTATTTTCCTGAAGGC
GACAGTCTGTCTTTTGGCGAGTCCAATTAGTGATCGTTTCCATTTATCCTTAACCCTCTGTTTGTGATCTTCCTGATTCCACCTACAAGT
TCATTAGTTCTAAATAAAAGCCTGTTGGCAAGTGTTGGTAGATTACAACTCTTTTTATTTGAAGTTGCTCGAGAAGTTAGACATGCTTTA
GAATTATGAGTGTGGGGAAAATTTGATGTTCCTTAGGATTATATAACTGAGGAGGGAACATTGCAAATAGGGTCTGAGGCTTTGTTTCTC
TCTTGCTCTGAAACATTTCTGAAAAGGCAAGGAAGGGAGGGGTAGTGTCTGGGGCAGTGCTGGTAGCCTGCATGTGTTGTAAATCATCCT
GCCATAACAAAGGACTGCATTGTTCTAGCTGGCCCACTGGGCAGGTCTGCCAGGCTACTTGGAACTGTAGTGGGAAGGTGGTTGATTGGA
GGGTTATCTGTATATAAAAGGTTTTCTCCCCTCCAAAGAAAGACTCCAGTACAAGATACCTGGTCCCAGGGAGTCTAAATTGTAACAGCA
ACCCCTGTGGACTTTGTGGGTATGAGTTTTGATTGAAATATAAAGCTTTCTTTTCTGTAAGTTTAAGTTTTCCATCTGACCATAGCAGAA
AAACCTAGACCCACCTAGTGAAACTTTGTAAGAACTCCAGGGCAAAAACGAACCACTTGCAACCCACATGTTTGTAGGTGTATGGTCGAT

>In-frame_ENST00000451218_ENST00000401642_TCGA-06-0174-01A_USP46_chr4_53494117_-_SCFD2_chr4_54140168_length(amino acids)=389AA_start in transcript=140_stop in transcript=1309
MTVRNIASICNMFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENGRVTPGQ
LMSYIQLFKNNLKALMNHCGLLQLGLATAQTLKHPQTAKWDNFLAFERLLLQSIGESAMSVVLNQLLPMIKPVTQRTNEDYSPEELLILL
IYIYSVTGELTVDKDLCEAEEKVKKALAQVFCEESGLSPLLQKITDWDSSINLTFHKSKIAVDELFTSLRDIAGARSLLKQFKSVYVPGN
HTHQASYKPLLKQVVEEIFHPERPDSVDIEHMSSGLTDLLKTGFSMFMKVSRPHPSDYPLLILFVVGGVTVSEVKMVKDLVASLKPGTQV

--------------------------------------------------------------
>In-frame_ENST00000451218_ENST00000388940_TCGA-06-0174-01A_USP46_chr4_53494117_-_SCFD2_chr4_54140168_length(transcript)=1356nt_BP=390nt
CTCCCTCTCCCAGCCAAACTGAAAGCCGGACCCCAGGCCGCCGCGCTGCCGCCCGGCCTCCCCGCCAGCGCGCCACCATGGGCAGTCCCG
GTTTCCCCTTGTAAAGATGGCGGTGAGGGATCGCTGCAACCTTTAGACTAATGACTGTCCGAAACATCGCCTCCATCTGTAATATGTTTG
GAAACACATGCTACTGTAACTCCGTGCTTCAGGCATTGTACTTCTGCCGTCCATTCCGGGAGAATGTGTTGGCATACAAGGCCCAGCAAA
AGAAGAAGGAAAACTTGCTGACGTGCCTGGCGGACCTTTTCCACAGCATTGCCACACAGAAGAAGAAGGTTGGCGTCATCCCACCAAAGA
AGTTCATTTCAAGGCTGAGAAAAGAGAATGGGAGAGTCACACCGGGACAGCTCATGTCCTATATTCAGCTCTTCAAGAACAACCTCAAAG
CTCTAATGAATCATTGTGGCCTCCTCCAGCTTGGACTGGCCACAGCTCAAACGTTGAAACACCCACAGACTGCCAAGTGGGACAACTTTC
TGGCTTTTGAAAGGCTCCTTCTTCAGAGCATTGGGGAGTCAGCAATGTCCGTTGTGTTAAATCAGCTGCTGCCCATGATTAAGCCTGTAA
CCCAGAGAACCAACGAGGACTACAGCCCTGAGGAACTGCTGATCCTTCTCATATATATTTATTCTGTCACTGGAGAGCTCACGGTAGACA
AAGACCTGTGTGAAGCAGAAGAAAAAGTCAAGAAAGCATTGGCTCAGGTCTTCTGTGAGGAATCTGGATTGTCACCTTTGCTGCAAAAAA
TTACGGACTGGGACTCTTCAATTAATCTGACATTTCACAAATCCAAAATTGCCGTGGATGAACTCTTTACTTCACTTCGGGATATTGCTG
GAGCTCGGAGTCTCCTGAAACAGTTTAAGTCTGTATATGTTCCTGGAAATCATACCCACCAGGTGAGCCGGCCTCATCCTAGTGACTACC
CCCTCCTGATCCTCTTTGTGGTAGGTGGGGTCACAGTCTCTGAAGTGAAAATGGTCAAAGATCTTGTGGCATCGTTGAAGCCAGGAACCC
AGGTAATCGTGCTGTCCACACGACTCCTGAAGCCACTTAACATTCCTGAGCTGTTATTTGCAACTGACCGACTGCATCCAGACCTTGGCT
TCTGAGCATCCGCTAAGAAGATAAGACCTACTCAAGCTGGAAATGCCGATGCAATTTTCTGCCACCACTCCAAATACTCCTCCACAACCA
GCGTCCCTGTCACTAATTGCGAGAATGATGGAATTCTGCCTGAAGGGTCTTGATACCTACTCAGTGAGGTACTTTGCTTGGATTGCTGTG

>In-frame_ENST00000451218_ENST00000388940_TCGA-06-0174-01A_USP46_chr4_53494117_-_SCFD2_chr4_54140168_length(amino acids)=344AA_start in transcript=140_stop in transcript=1174
MTVRNIASICNMFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENGRVTPGQ
LMSYIQLFKNNLKALMNHCGLLQLGLATAQTLKHPQTAKWDNFLAFERLLLQSIGESAMSVVLNQLLPMIKPVTQRTNEDYSPEELLILL
IYIYSVTGELTVDKDLCEAEEKVKKALAQVFCEESGLSPLLQKITDWDSSINLTFHKSKIAVDELFTSLRDIAGARSLLKQFKSVYVPGN

--------------------------------------------------------------
>In-frame_ENST00000508499_ENST00000401642_TCGA-06-0174-01A_USP46_chr4_53494117_-_SCFD2_chr4_54140168_length(transcript)=2497nt_BP=590nt
TGTTATGTCATCTACCAGGTGTTTAAGGGACAGTGGAGATCATGCCATTTCAGACCTGGTGGAAGCAACCACTAATATAAACACCTCCCA
TGTATAGGAAGGCTGGAGTGGGAATCCTTAACCCCGCCCCCTGCTCAGGTCAATCCCCCACCCACCGCCCCCACTGTCCCTCCCAGTCTT
CCTTCCCAGAGGAGAAGGCTGGGTATGAGGAAACTGCTGTCTTTTCACTGGATCAGACGTAAATATTAACTGGACCTCTCTTTAGATTCT
TTGCTCAATAATGAATTGTTTTCAGGGCACCAATGCCTCTGCTCTGGAAAAAGACATTGGTCCAGAGCAGTTTCCAATCAATGAACACTA
TTTCGGATTGGTCAATTTTGGAAACACATGCTACTGTAACTCCGTGCTTCAGGCATTGTACTTCTGCCGTCCATTCCGGGAGAATGTGTT
GGCATACAAGGCCCAGCAAAAGAAGAAGGAAAACTTGCTGACGTGCCTGGCGGACCTTTTCCACAGCATTGCCACACAGAAGAAGAAGGT
TGGCGTCATCCCACCAAAGAAGTTCATTTCAAGGCTGAGAAAAGAGAATGGGAGAGTCACACCGGGACAGCTCATGTCCTATATTCAGCT
CTTCAAGAACAACCTCAAAGCTCTAATGAATCATTGTGGCCTCCTCCAGCTTGGACTGGCCACAGCTCAAACGTTGAAACACCCACAGAC
TGCCAAGTGGGACAACTTTCTGGCTTTTGAAAGGCTCCTTCTTCAGAGCATTGGGGAGTCAGCAATGTCCGTTGTGTTAAATCAGCTGCT
GCCCATGATTAAGCCTGTAACCCAGAGAACCAACGAGGACTACAGCCCTGAGGAACTGCTGATCCTTCTCATATATATTTATTCTGTCAC
TGGAGAGCTCACGGTAGACAAAGACCTGTGTGAAGCAGAAGAAAAAGTCAAGAAAGCATTGGCTCAGGTCTTCTGTGAGGAATCTGGATT
GTCACCTTTGCTGCAAAAAATTACGGACTGGGACTCTTCAATTAATCTGACATTTCACAAATCCAAAATTGCCGTGGATGAACTCTTTAC
TTCACTTCGGGATATTGCTGGAGCTCGGAGTCTCCTGAAACAGTTTAAGTCTGTATATGTTCCTGGAAATCATACCCACCAGGCATCTTA
TAAGCCATTGTTGAAGCAAGTTGTGGAGGAAATATTTCATCCCGAGAGGCCAGATTCCGTTGATATTGAACACATGTCTTCAGGCCTCAC
TGATCTCCTTAAAACTGGATTTAGCATGTTCATGAAGGTGAGCCGGCCTCATCCTAGTGACTACCCCCTCCTGATCCTCTTTGTGGTAGG
TGGGGTCACAGTCTCTGAAGTGAAAATGGTCAAAGATCTTGTGGCATCGTTGAAGCCAGGAACCCAGGTAATCGTGCTGTCCACACGACT
CCTGAAGCCACTTAACATTCCTGAGCTGTTATTTGCAACTGACCGACTGCATCCAGACCTTGGCTTCTGAGCATCCGCTAAGAAGATAAG
ACCTACTCAAGCTGGAAATGCCGATGCAATTTTCTGCCACCACTCCAAATACTCCTCCACAACCAGCGTCCCTGTCACTAATTGCGAGAA
TGATGGAATTCTGCCTGAAGGGTCTTGATACCTACTCAGTGAGGTACTTTGCTTGGATTGCTGTGATTCTTAAAAAAAAAAAAAAAAAGT
TTTTTTATTTTCCTGAAGGCGACAGTCTGTCTTTTGGCGAGTCCAATTAGTGATCGTTTCCATTTATCCTTAACCCTCTGTTTGTGATCT
TCCTGATTCCACCTACAAGTTCATTAGTTCTAAATAAAAGCCTGTTGGCAAGTGTTGGTAGATTACAACTCTTTTTATTTGAAGTTGCTC
GAGAAGTTAGACATGCTTTAGAATTATGAGTGTGGGGAAAATTTGATGTTCCTTAGGATTATATAACTGAGGAGGGAACATTGCAAATAG
GGTCTGAGGCTTTGTTTCTCTCTTGCTCTGAAACATTTCTGAAAAGGCAAGGAAGGGAGGGGTAGTGTCTGGGGCAGTGCTGGTAGCCTG
CATGTGTTGTAAATCATCCTGCCATAACAAAGGACTGCATTGTTCTAGCTGGCCCACTGGGCAGGTCTGCCAGGCTACTTGGAACTGTAG
TGGGAAGGTGGTTGATTGGAGGGTTATCTGTATATAAAAGGTTTTCTCCCCTCCAAAGAAAGACTCCAGTACAAGATACCTGGTCCCAGG
GAGTCTAAATTGTAACAGCAACCCCTGTGGACTTTGTGGGTATGAGTTTTGATTGAAATATAAAGCTTTCTTTTCTGTAAGTTTAAGTTT
TCCATCTGACCATAGCAGAAAAACCTAGACCCACCTAGTGAAACTTTGTAAGAACTCCAGGGCAAAAACGAACCACTTGCAACCCACATG

>In-frame_ENST00000508499_ENST00000401642_TCGA-06-0174-01A_USP46_chr4_53494117_-_SCFD2_chr4_54140168_length(amino acids)=409AA_start in transcript=280_stop in transcript=1509
MNCFQGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVI
PPKKFISRLRKENGRVTPGQLMSYIQLFKNNLKALMNHCGLLQLGLATAQTLKHPQTAKWDNFLAFERLLLQSIGESAMSVVLNQLLPMI
KPVTQRTNEDYSPEELLILLIYIYSVTGELTVDKDLCEAEEKVKKALAQVFCEESGLSPLLQKITDWDSSINLTFHKSKIAVDELFTSLR
DIAGARSLLKQFKSVYVPGNHTHQASYKPLLKQVVEEIFHPERPDSVDIEHMSSGLTDLLKTGFSMFMKVSRPHPSDYPLLILFVVGGVT

--------------------------------------------------------------
>In-frame_ENST00000508499_ENST00000388940_TCGA-06-0174-01A_USP46_chr4_53494117_-_SCFD2_chr4_54140168_length(transcript)=1556nt_BP=590nt
TGTTATGTCATCTACCAGGTGTTTAAGGGACAGTGGAGATCATGCCATTTCAGACCTGGTGGAAGCAACCACTAATATAAACACCTCCCA
TGTATAGGAAGGCTGGAGTGGGAATCCTTAACCCCGCCCCCTGCTCAGGTCAATCCCCCACCCACCGCCCCCACTGTCCCTCCCAGTCTT
CCTTCCCAGAGGAGAAGGCTGGGTATGAGGAAACTGCTGTCTTTTCACTGGATCAGACGTAAATATTAACTGGACCTCTCTTTAGATTCT
TTGCTCAATAATGAATTGTTTTCAGGGCACCAATGCCTCTGCTCTGGAAAAAGACATTGGTCCAGAGCAGTTTCCAATCAATGAACACTA
TTTCGGATTGGTCAATTTTGGAAACACATGCTACTGTAACTCCGTGCTTCAGGCATTGTACTTCTGCCGTCCATTCCGGGAGAATGTGTT
GGCATACAAGGCCCAGCAAAAGAAGAAGGAAAACTTGCTGACGTGCCTGGCGGACCTTTTCCACAGCATTGCCACACAGAAGAAGAAGGT
TGGCGTCATCCCACCAAAGAAGTTCATTTCAAGGCTGAGAAAAGAGAATGGGAGAGTCACACCGGGACAGCTCATGTCCTATATTCAGCT
CTTCAAGAACAACCTCAAAGCTCTAATGAATCATTGTGGCCTCCTCCAGCTTGGACTGGCCACAGCTCAAACGTTGAAACACCCACAGAC
TGCCAAGTGGGACAACTTTCTGGCTTTTGAAAGGCTCCTTCTTCAGAGCATTGGGGAGTCAGCAATGTCCGTTGTGTTAAATCAGCTGCT
GCCCATGATTAAGCCTGTAACCCAGAGAACCAACGAGGACTACAGCCCTGAGGAACTGCTGATCCTTCTCATATATATTTATTCTGTCAC
TGGAGAGCTCACGGTAGACAAAGACCTGTGTGAAGCAGAAGAAAAAGTCAAGAAAGCATTGGCTCAGGTCTTCTGTGAGGAATCTGGATT
GTCACCTTTGCTGCAAAAAATTACGGACTGGGACTCTTCAATTAATCTGACATTTCACAAATCCAAAATTGCCGTGGATGAACTCTTTAC
TTCACTTCGGGATATTGCTGGAGCTCGGAGTCTCCTGAAACAGTTTAAGTCTGTATATGTTCCTGGAAATCATACCCACCAGGTGAGCCG
GCCTCATCCTAGTGACTACCCCCTCCTGATCCTCTTTGTGGTAGGTGGGGTCACAGTCTCTGAAGTGAAAATGGTCAAAGATCTTGTGGC
ATCGTTGAAGCCAGGAACCCAGGTAATCGTGCTGTCCACACGACTCCTGAAGCCACTTAACATTCCTGAGCTGTTATTTGCAACTGACCG
ACTGCATCCAGACCTTGGCTTCTGAGCATCCGCTAAGAAGATAAGACCTACTCAAGCTGGAAATGCCGATGCAATTTTCTGCCACCACTC
CAAATACTCCTCCACAACCAGCGTCCCTGTCACTAATTGCGAGAATGATGGAATTCTGCCTGAAGGGTCTTGATACCTACTCAGTGAGGT

>In-frame_ENST00000508499_ENST00000388940_TCGA-06-0174-01A_USP46_chr4_53494117_-_SCFD2_chr4_54140168_length(amino acids)=364AA_start in transcript=280_stop in transcript=1374
MNCFQGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVI
PPKKFISRLRKENGRVTPGQLMSYIQLFKNNLKALMNHCGLLQLGLATAQTLKHPQTAKWDNFLAFERLLLQSIGESAMSVVLNQLLPMI
KPVTQRTNEDYSPEELLILLIYIYSVTGELTVDKDLCEAEEKVKKALAQVFCEESGLSPLLQKITDWDSSINLTFHKSKIAVDELFTSLR
DIAGARSLLKQFKSVYVPGNHTHQVSRPHPSDYPLLILFVVGGVTVSEVKMVKDLVASLKPGTQVIVLSTRLLKPLNIPELLFATDRLHP

--------------------------------------------------------------
>In-frame_ENST00000441222_ENST00000401642_TCGA-CS-6665_USP46_chr4_53525282_-_SCFD2_chr4_53752033_length(transcript)=1421nt_BP=221nt
CGCTCCCTCCCCGCCCTCCCCGCGCCGCCGCCTCCTCCTCCCGGCCTCCCTCTCCCAGCCAAACTGAAAGCCGGACCCCAGGCCGCCGCG
CTGCCGCCCGGCCTCCCCGCCAGCGCGCCACCATGGGCAGTCCCGGTTTCCCCTTGTAAAGATGGCGGTGAGGGATCGCTGCAACCTTTA
GACTAATGACTGTCCGAAACATCGCCTCCATCTGTAATATGGTGAGCCGGCCTCATCCTAGTGACTACCCCCTCCTGATCCTCTTTGTGG
TAGGTGGGGTCACAGTCTCTGAAGTGAAAATGGTCAAAGATCTTGTGGCATCGTTGAAGCCAGGAACCCAGGTAATCGTGCTGTCCACAC
GACTCCTGAAGCCACTTAACATTCCTGAGCTGTTATTTGCAACTGACCGACTGCATCCAGACCTTGGCTTCTGAGCATCCGCTAAGAAGA
TAAGACCTACTCAAGCTGGAAATGCCGATGCAATTTTCTGCCACCACTCCAAATACTCCTCCACAACCAGCGTCCCTGTCACTAATTGCG
AGAATGATGGAATTCTGCCTGAAGGGTCTTGATACCTACTCAGTGAGGTACTTTGCTTGGATTGCTGTGATTCTTAAAAAAAAAAAAAAA
AAGTTTTTTTATTTTCCTGAAGGCGACAGTCTGTCTTTTGGCGAGTCCAATTAGTGATCGTTTCCATTTATCCTTAACCCTCTGTTTGTG
ATCTTCCTGATTCCACCTACAAGTTCATTAGTTCTAAATAAAAGCCTGTTGGCAAGTGTTGGTAGATTACAACTCTTTTTATTTGAAGTT
GCTCGAGAAGTTAGACATGCTTTAGAATTATGAGTGTGGGGAAAATTTGATGTTCCTTAGGATTATATAACTGAGGAGGGAACATTGCAA
ATAGGGTCTGAGGCTTTGTTTCTCTCTTGCTCTGAAACATTTCTGAAAAGGCAAGGAAGGGAGGGGTAGTGTCTGGGGCAGTGCTGGTAG
CCTGCATGTGTTGTAAATCATCCTGCCATAACAAAGGACTGCATTGTTCTAGCTGGCCCACTGGGCAGGTCTGCCAGGCTACTTGGAACT
GTAGTGGGAAGGTGGTTGATTGGAGGGTTATCTGTATATAAAAGGTTTTCTCCCCTCCAAAGAAAGACTCCAGTACAAGATACCTGGTCC
CAGGGAGTCTAAATTGTAACAGCAACCCCTGTGGACTTTGTGGGTATGAGTTTTGATTGAAATATAAAGCTTTCTTTTCTGTAAGTTTAA
GTTTTCCATCTGACCATAGCAGAAAAACCTAGACCCACCTAGTGAAACTTTGTAAGAACTCCAGGGCAAAAACGAACCACTTGCAACCCA

>In-frame_ENST00000441222_ENST00000401642_TCGA-CS-6665_USP46_chr4_53525282_-_SCFD2_chr4_53752033_length(amino acids)=153AA_start in transcript=1281_stop in transcript=820
MLWSDGKLKLTEKKALYFNQNSYPQSPQGLLLQFRLPGTRYLVLESFFGGEKTFYIQITLQSTTFPLQFQVAWQTCPVGQLEQCSPLLWQ

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>In-frame_ENST00000441222_ENST00000388940_TCGA-CS-6665_USP46_chr4_53525282_-_SCFD2_chr4_53752033_length(transcript)=615nt_BP=221nt
CGCTCCCTCCCCGCCCTCCCCGCGCCGCCGCCTCCTCCTCCCGGCCTCCCTCTCCCAGCCAAACTGAAAGCCGGACCCCAGGCCGCCGCG
CTGCCGCCCGGCCTCCCCGCCAGCGCGCCACCATGGGCAGTCCCGGTTTCCCCTTGTAAAGATGGCGGTGAGGGATCGCTGCAACCTTTA
GACTAATGACTGTCCGAAACATCGCCTCCATCTGTAATATGGTGAGCCGGCCTCATCCTAGTGACTACCCCCTCCTGATCCTCTTTGTGG
TAGGTGGGGTCACAGTCTCTGAAGTGAAAATGGTCAAAGATCTTGTGGCATCGTTGAAGCCAGGAACCCAGGTAATCGTGCTGTCCACAC
GACTCCTGAAGCCACTTAACATTCCTGAGCTGTTATTTGCAACTGACCGACTGCATCCAGACCTTGGCTTCTGAGCATCCGCTAAGAAGA
TAAGACCTACTCAAGCTGGAAATGCCGATGCAATTTTCTGCCACCACTCCAAATACTCCTCCACAACCAGCGTCCCTGTCACTAATTGCG

>In-frame_ENST00000441222_ENST00000388940_TCGA-CS-6665_USP46_chr4_53525282_-_SCFD2_chr4_53752033_length(amino acids)=82AA_start in transcript=185_stop in transcript=433

--------------------------------------------------------------
>In-frame_ENST00000451218_ENST00000401642_TCGA-CS-6665_USP46_chr4_53525282_-_SCFD2_chr4_53752033_length(transcript)=1376nt_BP=176nt
CTCCCTCTCCCAGCCAAACTGAAAGCCGGACCCCAGGCCGCCGCGCTGCCGCCCGGCCTCCCCGCCAGCGCGCCACCATGGGCAGTCCCG
GTTTCCCCTTGTAAAGATGGCGGTGAGGGATCGCTGCAACCTTTAGACTAATGACTGTCCGAAACATCGCCTCCATCTGTAATATGGTGA
GCCGGCCTCATCCTAGTGACTACCCCCTCCTGATCCTCTTTGTGGTAGGTGGGGTCACAGTCTCTGAAGTGAAAATGGTCAAAGATCTTG
TGGCATCGTTGAAGCCAGGAACCCAGGTAATCGTGCTGTCCACACGACTCCTGAAGCCACTTAACATTCCTGAGCTGTTATTTGCAACTG
ACCGACTGCATCCAGACCTTGGCTTCTGAGCATCCGCTAAGAAGATAAGACCTACTCAAGCTGGAAATGCCGATGCAATTTTCTGCCACC
ACTCCAAATACTCCTCCACAACCAGCGTCCCTGTCACTAATTGCGAGAATGATGGAATTCTGCCTGAAGGGTCTTGATACCTACTCAGTG
AGGTACTTTGCTTGGATTGCTGTGATTCTTAAAAAAAAAAAAAAAAAGTTTTTTTATTTTCCTGAAGGCGACAGTCTGTCTTTTGGCGAG
TCCAATTAGTGATCGTTTCCATTTATCCTTAACCCTCTGTTTGTGATCTTCCTGATTCCACCTACAAGTTCATTAGTTCTAAATAAAAGC
CTGTTGGCAAGTGTTGGTAGATTACAACTCTTTTTATTTGAAGTTGCTCGAGAAGTTAGACATGCTTTAGAATTATGAGTGTGGGGAAAA
TTTGATGTTCCTTAGGATTATATAACTGAGGAGGGAACATTGCAAATAGGGTCTGAGGCTTTGTTTCTCTCTTGCTCTGAAACATTTCTG
AAAAGGCAAGGAAGGGAGGGGTAGTGTCTGGGGCAGTGCTGGTAGCCTGCATGTGTTGTAAATCATCCTGCCATAACAAAGGACTGCATT
GTTCTAGCTGGCCCACTGGGCAGGTCTGCCAGGCTACTTGGAACTGTAGTGGGAAGGTGGTTGATTGGAGGGTTATCTGTATATAAAAGG
TTTTCTCCCCTCCAAAGAAAGACTCCAGTACAAGATACCTGGTCCCAGGGAGTCTAAATTGTAACAGCAACCCCTGTGGACTTTGTGGGT
ATGAGTTTTGATTGAAATATAAAGCTTTCTTTTCTGTAAGTTTAAGTTTTCCATCTGACCATAGCAGAAAAACCTAGACCCACCTAGTGA
AACTTTGTAAGAACTCCAGGGCAAAAACGAACCACTTGCAACCCACATGTTTGTAGGTGTATGGTCGATGGAAGTTTCTGGCATCCATGT

>In-frame_ENST00000451218_ENST00000401642_TCGA-CS-6665_USP46_chr4_53525282_-_SCFD2_chr4_53752033_length(amino acids)=153AA_start in transcript=1236_stop in transcript=775
MLWSDGKLKLTEKKALYFNQNSYPQSPQGLLLQFRLPGTRYLVLESFFGGEKTFYIQITLQSTTFPLQFQVAWQTCPVGQLEQCSPLLWQ

--------------------------------------------------------------
>In-frame_ENST00000451218_ENST00000388940_TCGA-CS-6665_USP46_chr4_53525282_-_SCFD2_chr4_53752033_length(transcript)=570nt_BP=176nt
CTCCCTCTCCCAGCCAAACTGAAAGCCGGACCCCAGGCCGCCGCGCTGCCGCCCGGCCTCCCCGCCAGCGCGCCACCATGGGCAGTCCCG
GTTTCCCCTTGTAAAGATGGCGGTGAGGGATCGCTGCAACCTTTAGACTAATGACTGTCCGAAACATCGCCTCCATCTGTAATATGGTGA
GCCGGCCTCATCCTAGTGACTACCCCCTCCTGATCCTCTTTGTGGTAGGTGGGGTCACAGTCTCTGAAGTGAAAATGGTCAAAGATCTTG
TGGCATCGTTGAAGCCAGGAACCCAGGTAATCGTGCTGTCCACACGACTCCTGAAGCCACTTAACATTCCTGAGCTGTTATTTGCAACTG
ACCGACTGCATCCAGACCTTGGCTTCTGAGCATCCGCTAAGAAGATAAGACCTACTCAAGCTGGAAATGCCGATGCAATTTTCTGCCACC
ACTCCAAATACTCCTCCACAACCAGCGTCCCTGTCACTAATTGCGAGAATGATGGAATTCTGCCTGAAGGGTCTTGATACCTACTCAGTG

>In-frame_ENST00000451218_ENST00000388940_TCGA-CS-6665_USP46_chr4_53525282_-_SCFD2_chr4_53752033_length(amino acids)=82AA_start in transcript=140_stop in transcript=388

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USP46-SCFD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP46-SCFD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP46-SCFD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSP46C0005586Bipolar Disorder1PSYGENET
HgeneUSP46C1269683Major Depressive Disorder1PSYGENET