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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP48-INA (FusionGDB2 ID:96868)

Fusion Gene Summary for USP48-INA

check button Fusion gene summary
Fusion gene informationFusion gene name: USP48-INA
Fusion gene ID: 96868
HgeneTgene
Gene symbol

USP48

INA

Gene ID

84196

9118

Gene nameubiquitin specific peptidase 48internexin neuronal intermediate filament protein alpha
SynonymsRAP1GA1|USP31NEF5|NF-66|TXBP-1
Cytomap

1p36.12

10q24.33

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 48deubiquitinating enzyme 48ubiquitin specific protease 31ubiquitin thioesterase 48ubiquitin thiolesterase 48ubiquitin-specific-processing protease 48alpha-internexin66 kDa neurofilament proteinalpha-Inxneurofilament 5 (66kD)neurofilament-66, tax-binding protein
Modification date2020031320200313
UniProtAcc.

Q3KP66

Ensembl transtripts involved in fusion geneENST00000400301, ENST00000308271, 
ENST00000374732, ENST00000529637, 
ENST00000479177, ENST00000421625, 
ENST00000369849, 
Fusion gene scores* DoF score22 X 16 X 9=31684 X 2 X 3=24
# samples 255
** MAII scorelog2(25/3168*10)=-3.66357233541752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/24*10)=1.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: USP48 [Title/Abstract] AND INA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP48(22109317)-INA(105046792), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across USP48 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across INA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3BF-01AUSP48chr1

22109317

-INAchr10

105046792

+
ChimerDB4UCECTCGA-AJ-A3BFUSP48chr1

22109316

-INAchr10

105046791

+
ChimerDB4UCECTCGA-AJ-A3BF-01AUSP48chr1

22109317

-INAchr10

105046792

+
ChimerDB4UCECTCGA-AJ-A3BF-01AUSP48chr1

22109317

-INAchr10

105046792

+
ChimerDB4UCECTCGA-AJ-A3BF-01AUSP48chr1

22109316

-INAchr10

105046791

+


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Fusion Gene ORF analysis for USP48-INA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000400301ENST00000369849USP48chr1

22109317

-INAchr10

105046792

+
In-frameENST00000308271ENST00000369849USP48chr1

22109317

-INAchr10

105046792

+
intron-3CDSENST00000374732ENST00000369849USP48chr1

22109317

-INAchr10

105046792

+
In-frameENST00000529637ENST00000369849USP48chr1

22109317

-INAchr10

105046792

+
intron-3CDSENST00000479177ENST00000369849USP48chr1

22109317

-INAchr10

105046792

+
In-frameENST00000421625ENST00000369849USP48chr1

22109317

-INAchr10

105046792

+
In-frameENST00000400301ENST00000369849USP48chr1

22109316

-INAchr10

105046791

+
In-frameENST00000308271ENST00000369849USP48chr1

22109316

-INAchr10

105046791

+
intron-3CDSENST00000374732ENST00000369849USP48chr1

22109316

-INAchr10

105046791

+
In-frameENST00000529637ENST00000369849USP48chr1

22109316

-INAchr10

105046791

+
intron-3CDSENST00000479177ENST00000369849USP48chr1

22109316

-INAchr10

105046791

+
In-frameENST00000421625ENST00000369849USP48chr1

22109316

-INAchr10

105046791

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400301USP48chr122109317-ENST00000369849INAchr10105046792+2489372105806233
ENST00000308271USP48chr122109317-ENST00000369849INAchr10105046792+29007835161217233
ENST00000529637USP48chr122109317-ENST00000369849INAchr10105046792+228516866602178
ENST00000421625USP48chr122109317-ENST00000369849INAchr10105046792+29007835161217233
ENST00000400301USP48chr122109316-ENST00000369849INAchr10105046791+2489372105806233
ENST00000308271USP48chr122109316-ENST00000369849INAchr10105046791+29007835161217233
ENST00000529637USP48chr122109316-ENST00000369849INAchr10105046791+228516866602178
ENST00000421625USP48chr122109316-ENST00000369849INAchr10105046791+29007835161217233

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400301ENST00000369849USP48chr122109317-INAchr10105046792+0.0112809680.98871905
ENST00000308271ENST00000369849USP48chr122109317-INAchr10105046792+0.0177988370.98220116
ENST00000529637ENST00000369849USP48chr122109317-INAchr10105046792+0.0154560490.984544
ENST00000421625ENST00000369849USP48chr122109317-INAchr10105046792+0.0177988370.98220116
ENST00000400301ENST00000369849USP48chr122109316-INAchr10105046791+0.0112809680.98871905
ENST00000308271ENST00000369849USP48chr122109316-INAchr10105046791+0.0177988370.98220116
ENST00000529637ENST00000369849USP48chr122109316-INAchr10105046791+0.0154560490.984544
ENST00000421625ENST00000369849USP48chr122109316-INAchr10105046791+0.0177988370.98220116

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Fusion Genomic Features for USP48-INA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USP48chr122109316-INAchr10105046791+4.16E-151
USP48chr122109316-INAchr10105046791+4.16E-151
USP48chr122109316-INAchr10105046791+4.16E-151
USP48chr122109316-INAchr10105046791+4.16E-151

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP48-INA


check button Go to

FGviewer for the breakpoints of chr1:22109317-chr10:105046792

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.INA

Q3KP66

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). {ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:29420262}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneINAchr1:22109316chr10:105046791ENST0000036984903449_454355.0500.0Compositional biasNote=Poly-Glu
TgeneINAchr1:22109317chr10:105046792ENST0000036984903449_454355.0500.0Compositional biasNote=Poly-Glu
TgeneINAchr1:22109316chr10:105046791ENST0000036984903409_499355.0500.0RegionNote=Tail
TgeneINAchr1:22109317chr10:105046792ENST0000036984903409_499355.0500.0RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP48chr1:22109316chr10:105046791ENST00000308271-127460_55444.6666666666666641036.0DomainDUSP 1
HgeneUSP48chr1:22109316chr10:105046791ENST00000308271-127569_69144.6666666666666641036.0DomainDUSP 2
HgeneUSP48chr1:22109316chr10:105046791ENST00000308271-127711_82444.6666666666666641036.0DomainDUSP 3
HgeneUSP48chr1:22109316chr10:105046791ENST00000308271-12789_42144.6666666666666641036.0DomainNote=USP
HgeneUSP48chr1:22109316chr10:105046791ENST00000308271-127929_100944.6666666666666641036.0DomainUbiquitin-like
HgeneUSP48chr1:22109316chr10:105046791ENST00000400301-126460_55444.666666666666664984.0DomainDUSP 1
HgeneUSP48chr1:22109316chr10:105046791ENST00000400301-126569_69144.666666666666664984.0DomainDUSP 2
HgeneUSP48chr1:22109316chr10:105046791ENST00000400301-126711_82444.666666666666664984.0DomainDUSP 3
HgeneUSP48chr1:22109316chr10:105046791ENST00000400301-12689_42144.666666666666664984.0DomainNote=USP
HgeneUSP48chr1:22109316chr10:105046791ENST00000400301-126929_100944.666666666666664984.0DomainUbiquitin-like
HgeneUSP48chr1:22109316chr10:105046791ENST00000421625-111460_55444.666666666666664486.0DomainDUSP 1
HgeneUSP48chr1:22109316chr10:105046791ENST00000421625-111569_69144.666666666666664486.0DomainDUSP 2
HgeneUSP48chr1:22109316chr10:105046791ENST00000421625-111711_82444.666666666666664486.0DomainDUSP 3
HgeneUSP48chr1:22109316chr10:105046791ENST00000421625-11189_42144.666666666666664486.0DomainNote=USP
HgeneUSP48chr1:22109316chr10:105046791ENST00000421625-111929_100944.666666666666664486.0DomainUbiquitin-like
HgeneUSP48chr1:22109317chr10:105046792ENST00000308271-127460_55444.6666666666666641036.0DomainDUSP 1
HgeneUSP48chr1:22109317chr10:105046792ENST00000308271-127569_69144.6666666666666641036.0DomainDUSP 2
HgeneUSP48chr1:22109317chr10:105046792ENST00000308271-127711_82444.6666666666666641036.0DomainDUSP 3
HgeneUSP48chr1:22109317chr10:105046792ENST00000308271-12789_42144.6666666666666641036.0DomainNote=USP
HgeneUSP48chr1:22109317chr10:105046792ENST00000308271-127929_100944.6666666666666641036.0DomainUbiquitin-like
HgeneUSP48chr1:22109317chr10:105046792ENST00000400301-126460_55444.666666666666664984.0DomainDUSP 1
HgeneUSP48chr1:22109317chr10:105046792ENST00000400301-126569_69144.666666666666664984.0DomainDUSP 2
HgeneUSP48chr1:22109317chr10:105046792ENST00000400301-126711_82444.666666666666664984.0DomainDUSP 3
HgeneUSP48chr1:22109317chr10:105046792ENST00000400301-12689_42144.666666666666664984.0DomainNote=USP
HgeneUSP48chr1:22109317chr10:105046792ENST00000400301-126929_100944.666666666666664984.0DomainUbiquitin-like
HgeneUSP48chr1:22109317chr10:105046792ENST00000421625-111460_55444.666666666666664486.0DomainDUSP 1
HgeneUSP48chr1:22109317chr10:105046792ENST00000421625-111569_69144.666666666666664486.0DomainDUSP 2
HgeneUSP48chr1:22109317chr10:105046792ENST00000421625-111711_82444.666666666666664486.0DomainDUSP 3
HgeneUSP48chr1:22109317chr10:105046792ENST00000421625-11189_42144.666666666666664486.0DomainNote=USP
HgeneUSP48chr1:22109317chr10:105046792ENST00000421625-111929_100944.666666666666664486.0DomainUbiquitin-like
TgeneINAchr1:22109316chr10:105046791ENST000003698490394_407355.0500.0DomainIF rod
TgeneINAchr1:22109317chr10:105046792ENST000003698490394_407355.0500.0DomainIF rod
TgeneINAchr1:22109316chr10:105046791ENST0000036984903130_142355.0500.0RegionNote=Linker 1
TgeneINAchr1:22109316chr10:105046791ENST0000036984903143_238355.0500.0RegionNote=Coil 1B
TgeneINAchr1:22109316chr10:105046791ENST00000369849031_87355.0500.0RegionNote=Head
TgeneINAchr1:22109316chr10:105046791ENST0000036984903239_262355.0500.0RegionNote=Linker 2
TgeneINAchr1:22109316chr10:105046791ENST0000036984903263_408355.0500.0RegionNote=Coil 2
TgeneINAchr1:22109316chr10:105046791ENST000003698490388_129355.0500.0RegionNote=Coil 1A
TgeneINAchr1:22109317chr10:105046792ENST0000036984903130_142355.0500.0RegionNote=Linker 1
TgeneINAchr1:22109317chr10:105046792ENST0000036984903143_238355.0500.0RegionNote=Coil 1B
TgeneINAchr1:22109317chr10:105046792ENST00000369849031_87355.0500.0RegionNote=Head
TgeneINAchr1:22109317chr10:105046792ENST0000036984903239_262355.0500.0RegionNote=Linker 2
TgeneINAchr1:22109317chr10:105046792ENST0000036984903263_408355.0500.0RegionNote=Coil 2
TgeneINAchr1:22109317chr10:105046792ENST000003698490388_129355.0500.0RegionNote=Coil 1A


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Fusion Gene Sequence for USP48-INA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000400301_ENST00000369849_TCGA-AJ-A3BF-01A_USP48_chr1_22109317_-_INA_chr10_105046792_length(transcript)=2489nt_BP=372nt
AACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCGGCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGT
GGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGAGCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTG
CAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGGCGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGC
CTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTCGCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCG
CGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGAC
TTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGG
TTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCC
ACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAA
GAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTC
CATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATATGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCA
CTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTATTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAA
CTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAATACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGT
GCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCATCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATT
ACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATAAGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATA
GAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACACTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAA
ATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTTGGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAA
ATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATTACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATG
GCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAATAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTT
AATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCTTTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAG
ATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATGAGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATAT
AGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACGTATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTC
CTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTCACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAA
TCAACACTACCAGCGTATATATAAGAAAGACATCTTTCTCTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGG
GGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAGGGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGC
TCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAGTCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTC
ACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCCATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACT
TTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTTGAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACAC

>In-frame_ENST00000400301_ENST00000369849_TCGA-AJ-A3BF-01A_USP48_chr1_22109317_-_INA_chr10_105046792_length(amino acids)=233AA_start in transcript=105_stop in transcript=806
MTGQLPEGAPGPPCWQVAKPIGAAVQTAAAAAAVWLGRRSWGQGHGPAAAAGEGGLALGGDGAARGGVAGAHRDRLPHLAGALHSRRVQD
SIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSL

--------------------------------------------------------------
>In-frame_ENST00000308271_ENST00000369849_TCGA-AJ-A3BF-01A_USP48_chr1_22109317_-_INA_chr10_105046792_length(transcript)=2900nt_BP=783nt
GCTCGGGAAAGGGGTTCGGAACCGGTCTAGGCTCAAGTTAAATCTCCCTCTAAAGAGCCAACACTGGTTTCTTTGGCGACTCGGTTTCTA
CTCTAAACAGGTCCCGCTCCACAGTCTGGGCGGGCCTGTGTGTGCGTTGAGTAGCCTCTAGCGTGAAAACTTCATGGTTAAAAGGGAAGT
ACCGGAGGCAAGAAATAGCTTTCGAGGCACTGGTTTGTTAGAGTAGTGGTACGTAGTGCGCCGCCCTGAACGGGGGCTGAGACGCTGCTT
TTCCAGAAGTGCCAGTGAGGACGTGGCAAGACCGCCTCGGACGTACGCTTCCTCTACCTCAGCCCGTCGGGTTAGGGGCGCGGGAGGCGC
AGAGGCTGCTGGGAACGCGCATGCGCTCAGCGCGGCGGGGAGTCCACCTTTAACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCG
GCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGTGGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGA
GCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTGCAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGG
CGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTC
GCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGAT
CTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCA
GCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGT
TACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAG
GCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACC
GAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATA
TGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTA
TTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAA
TACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCA
TCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATA
AGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACA
CTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTT
GGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATT
ACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAA
TAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCT
TTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATG
AGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACG
TATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTC
ACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAAGAAAGACATCTTTCT
CTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAG
GGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAG
TCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCC
ATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTT
GAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACACTTACTGTAAGACATTAGTAACATAATAAATTAAAAGTCA

>In-frame_ENST00000308271_ENST00000369849_TCGA-AJ-A3BF-01A_USP48_chr1_22109317_-_INA_chr10_105046792_length(amino acids)=233AA_start in transcript=516_stop in transcript=1217
MTGQLPEGAPGPPCWQVAKPIGAAVQTAAAAAAVWLGRRSWGQGHGPAAAAGEGGLALGGDGAARGGVAGAHRDRLPHLAGALHSRRVQD
SIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSL

--------------------------------------------------------------
>In-frame_ENST00000529637_ENST00000369849_TCGA-AJ-A3BF-01A_USP48_chr1_22109317_-_INA_chr10_105046792_length(transcript)=2285nt_BP=168nt
GTCTGGCTCGGGAGGCGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCG
GCCCGAGGAGGTGTCGCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGG
CAGCTGGAGAATGATCTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTT
GACATTGAGATAGCAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCA
CTTCCCAATCCAAGTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAG
GAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATA
TCTACTAAGAAAACCGAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCT
TAAGAGGGAATGATATGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCA
GTCTCATATTTAGTATTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGA
TGAGTTATCTAAGAATACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTG
CTAAATCTGCGATCATCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTA
GATACCTAAAACATAAGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTG
TTTGTTTAATGGACACTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCC
TTTTAAACACATTTTGGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCT
ATGATTCGTGTAATTACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTC
CCCCAACATATAAAATAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGA
TGTAGCTTTTCACCTTTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAA
GTGAGTGTTTCTATGAGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTA
CCCTTAGAATCCACGTATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGT
GTAGGATATTTTGTCACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAA
GAAAGACATCTTTCTCTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACA
CTCAGACCAGAGAAGGGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGC
ATCTGCATTGCCCAGTCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTG
CCCCGTCTCTGTTCCATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAA
TAGTTCAAGGAACTTGAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACACTTACTGTAAGACATTAGTAACATA

>In-frame_ENST00000529637_ENST00000369849_TCGA-AJ-A3BF-01A_USP48_chr1_22109317_-_INA_chr10_105046792_length(amino acids)=178AA_start in transcript=66_stop in transcript=602
MALGGDGAARGGVAGAHRDRLPHLAGALHSRRVQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSG

--------------------------------------------------------------
>In-frame_ENST00000421625_ENST00000369849_TCGA-AJ-A3BF-01A_USP48_chr1_22109317_-_INA_chr10_105046792_length(transcript)=2900nt_BP=783nt
GCTCGGGAAAGGGGTTCGGAACCGGTCTAGGCTCAAGTTAAATCTCCCTCTAAAGAGCCAACACTGGTTTCTTTGGCGACTCGGTTTCTA
CTCTAAACAGGTCCCGCTCCACAGTCTGGGCGGGCCTGTGTGTGCGTTGAGTAGCCTCTAGCGTGAAAACTTCATGGTTAAAAGGGAAGT
ACCGGAGGCAAGAAATAGCTTTCGAGGCACTGGTTTGTTAGAGTAGTGGTACGTAGTGCGCCGCCCTGAACGGGGGCTGAGACGCTGCTT
TTCCAGAAGTGCCAGTGAGGACGTGGCAAGACCGCCTCGGACGTACGCTTCCTCTACCTCAGCCCGTCGGGTTAGGGGCGCGGGAGGCGC
AGAGGCTGCTGGGAACGCGCATGCGCTCAGCGCGGCGGGGAGTCCACCTTTAACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCG
GCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGTGGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGA
GCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTGCAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGG
CGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTC
GCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGAT
CTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCA
GCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGT
TACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAG
GCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACC
GAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATA
TGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTA
TTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAA
TACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCA
TCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATA
AGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACA
CTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTT
GGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATT
ACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAA
TAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCT
TTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATG
AGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACG
TATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTC
ACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAAGAAAGACATCTTTCT
CTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAG
GGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAG
TCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCC
ATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTT
GAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACACTTACTGTAAGACATTAGTAACATAATAAATTAAAAGTCA

>In-frame_ENST00000421625_ENST00000369849_TCGA-AJ-A3BF-01A_USP48_chr1_22109317_-_INA_chr10_105046792_length(amino acids)=233AA_start in transcript=516_stop in transcript=1217
MTGQLPEGAPGPPCWQVAKPIGAAVQTAAAAAAVWLGRRSWGQGHGPAAAAGEGGLALGGDGAARGGVAGAHRDRLPHLAGALHSRRVQD
SIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSL

--------------------------------------------------------------
>In-frame_ENST00000400301_ENST00000369849_TCGA-AJ-A3BF_USP48_chr1_22109316_-_INA_chr10_105046791_length(transcript)=2489nt_BP=372nt
AACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCGGCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGT
GGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGAGCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTG
CAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGGCGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGC
CTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTCGCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCG
CGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGAC
TTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGG
TTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCC
ACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAA
GAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTC
CATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATATGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCA
CTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTATTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAA
CTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAATACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGT
GCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCATCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATT
ACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATAAGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATA
GAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACACTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAA
ATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTTGGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAA
ATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATTACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATG
GCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAATAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTT
AATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCTTTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAG
ATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATGAGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATAT
AGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACGTATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTC
CTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTCACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAA
TCAACACTACCAGCGTATATATAAGAAAGACATCTTTCTCTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGG
GGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAGGGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGC
TCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAGTCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTC
ACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCCATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACT
TTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTTGAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACAC

>In-frame_ENST00000400301_ENST00000369849_TCGA-AJ-A3BF_USP48_chr1_22109316_-_INA_chr10_105046791_length(amino acids)=233AA_start in transcript=105_stop in transcript=806
MTGQLPEGAPGPPCWQVAKPIGAAVQTAAAAAAVWLGRRSWGQGHGPAAAAGEGGLALGGDGAARGGVAGAHRDRLPHLAGALHSRRVQD
SIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSL

--------------------------------------------------------------
>In-frame_ENST00000308271_ENST00000369849_TCGA-AJ-A3BF_USP48_chr1_22109316_-_INA_chr10_105046791_length(transcript)=2900nt_BP=783nt
GCTCGGGAAAGGGGTTCGGAACCGGTCTAGGCTCAAGTTAAATCTCCCTCTAAAGAGCCAACACTGGTTTCTTTGGCGACTCGGTTTCTA
CTCTAAACAGGTCCCGCTCCACAGTCTGGGCGGGCCTGTGTGTGCGTTGAGTAGCCTCTAGCGTGAAAACTTCATGGTTAAAAGGGAAGT
ACCGGAGGCAAGAAATAGCTTTCGAGGCACTGGTTTGTTAGAGTAGTGGTACGTAGTGCGCCGCCCTGAACGGGGGCTGAGACGCTGCTT
TTCCAGAAGTGCCAGTGAGGACGTGGCAAGACCGCCTCGGACGTACGCTTCCTCTACCTCAGCCCGTCGGGTTAGGGGCGCGGGAGGCGC
AGAGGCTGCTGGGAACGCGCATGCGCTCAGCGCGGCGGGGAGTCCACCTTTAACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCG
GCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGTGGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGA
GCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTGCAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGG
CGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTC
GCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGAT
CTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCA
GCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGT
TACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAG
GCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACC
GAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATA
TGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTA
TTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAA
TACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCA
TCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATA
AGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACA
CTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTT
GGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATT
ACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAA
TAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCT
TTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATG
AGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACG
TATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTC
ACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAAGAAAGACATCTTTCT
CTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAG
GGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAG
TCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCC
ATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTT
GAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACACTTACTGTAAGACATTAGTAACATAATAAATTAAAAGTCA

>In-frame_ENST00000308271_ENST00000369849_TCGA-AJ-A3BF_USP48_chr1_22109316_-_INA_chr10_105046791_length(amino acids)=233AA_start in transcript=516_stop in transcript=1217
MTGQLPEGAPGPPCWQVAKPIGAAVQTAAAAAAVWLGRRSWGQGHGPAAAAGEGGLALGGDGAARGGVAGAHRDRLPHLAGALHSRRVQD
SIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSL

--------------------------------------------------------------
>In-frame_ENST00000529637_ENST00000369849_TCGA-AJ-A3BF_USP48_chr1_22109316_-_INA_chr10_105046791_length(transcript)=2285nt_BP=168nt
GTCTGGCTCGGGAGGCGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCG
GCCCGAGGAGGTGTCGCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGG
CAGCTGGAGAATGATCTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTT
GACATTGAGATAGCAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCA
CTTCCCAATCCAAGTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAG
GAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATA
TCTACTAAGAAAACCGAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCT
TAAGAGGGAATGATATGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCA
GTCTCATATTTAGTATTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGA
TGAGTTATCTAAGAATACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTG
CTAAATCTGCGATCATCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTA
GATACCTAAAACATAAGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTG
TTTGTTTAATGGACACTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCC
TTTTAAACACATTTTGGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCT
ATGATTCGTGTAATTACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTC
CCCCAACATATAAAATAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGA
TGTAGCTTTTCACCTTTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAA
GTGAGTGTTTCTATGAGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTA
CCCTTAGAATCCACGTATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGT
GTAGGATATTTTGTCACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAA
GAAAGACATCTTTCTCTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACA
CTCAGACCAGAGAAGGGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGC
ATCTGCATTGCCCAGTCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTG
CCCCGTCTCTGTTCCATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAA
TAGTTCAAGGAACTTGAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACACTTACTGTAAGACATTAGTAACATA

>In-frame_ENST00000529637_ENST00000369849_TCGA-AJ-A3BF_USP48_chr1_22109316_-_INA_chr10_105046791_length(amino acids)=178AA_start in transcript=66_stop in transcript=602
MALGGDGAARGGVAGAHRDRLPHLAGALHSRRVQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSG

--------------------------------------------------------------
>In-frame_ENST00000421625_ENST00000369849_TCGA-AJ-A3BF_USP48_chr1_22109316_-_INA_chr10_105046791_length(transcript)=2900nt_BP=783nt
GCTCGGGAAAGGGGTTCGGAACCGGTCTAGGCTCAAGTTAAATCTCCCTCTAAAGAGCCAACACTGGTTTCTTTGGCGACTCGGTTTCTA
CTCTAAACAGGTCCCGCTCCACAGTCTGGGCGGGCCTGTGTGTGCGTTGAGTAGCCTCTAGCGTGAAAACTTCATGGTTAAAAGGGAAGT
ACCGGAGGCAAGAAATAGCTTTCGAGGCACTGGTTTGTTAGAGTAGTGGTACGTAGTGCGCCGCCCTGAACGGGGGCTGAGACGCTGCTT
TTCCAGAAGTGCCAGTGAGGACGTGGCAAGACCGCCTCGGACGTACGCTTCCTCTACCTCAGCCCGTCGGGTTAGGGGCGCGGGAGGCGC
AGAGGCTGCTGGGAACGCGCATGCGCTCAGCGCGGCGGGGAGTCCACCTTTAACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCG
GCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGTGGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGA
GCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTGCAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGG
CGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTC
GCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGAT
CTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCA
GCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGT
TACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAG
GCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACC
GAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATA
TGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTA
TTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAA
TACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCA
TCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATA
AGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACA
CTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTT
GGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATT
ACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAA
TAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCT
TTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATG
AGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACG
TATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTC
ACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAAGAAAGACATCTTTCT
CTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAG
GGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAG
TCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCC
ATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTT
GAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACACTTACTGTAAGACATTAGTAACATAATAAATTAAAAGTCA

>In-frame_ENST00000421625_ENST00000369849_TCGA-AJ-A3BF_USP48_chr1_22109316_-_INA_chr10_105046791_length(amino acids)=233AA_start in transcript=516_stop in transcript=1217
MTGQLPEGAPGPPCWQVAKPIGAAVQTAAAAAAVWLGRRSWGQGHGPAAAAGEGGLALGGDGAARGGVAGAHRDRLPHLAGALHSRRVQD
SIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSL

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Fusion Gene PPI Analysis for USP48-INA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP48-INA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP48-INA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSP48C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneUSP48C0236733Amphetamine-Related Disorders1CTD_human
HgeneUSP48C0236804Amphetamine Addiction1CTD_human
HgeneUSP48C0236807Amphetamine Abuse1CTD_human
TgeneINAC0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneINAC0524851Neurodegenerative Disorders1CTD_human
TgeneINAC0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneINAC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneINAC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneINAC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human