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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP48-MAN1C1 (FusionGDB2 ID:96870)

Fusion Gene Summary for USP48-MAN1C1

check button Fusion gene summary
Fusion gene informationFusion gene name: USP48-MAN1C1
Fusion gene ID: 96870
HgeneTgene
Gene symbol

USP48

MAN1C1

Gene ID

84196

57134

Gene nameubiquitin specific peptidase 48mannosidase alpha class 1C member 1
SynonymsRAP1GA1|USP31HMIC|MAN1A3|MAN1C|pp6318
Cytomap

1p36.12

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 48deubiquitinating enzyme 48ubiquitin specific protease 31ubiquitin thioesterase 48ubiquitin thiolesterase 48ubiquitin-specific-processing protease 48mannosyl-oligosaccharide 1,2-alpha-mannosidase IC1,2-alpha-mannosidase ICprocessing alpha-1,2-mannosidase IC
Modification date2020031320200313
UniProtAcc.

Q9NR34

Ensembl transtripts involved in fusion geneENST00000400301, ENST00000308271, 
ENST00000374732, ENST00000529637, 
ENST00000479177, ENST00000421625, 
ENST00000374332, ENST00000263979, 
ENST00000473891, ENST00000374329, 
Fusion gene scores* DoF score22 X 16 X 9=31686 X 6 X 5=180
# samples 257
** MAII scorelog2(25/3168*10)=-3.66357233541752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP48 [Title/Abstract] AND MAN1C1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP48(22109317)-MAN1C1(26110154), # samples:3
Anticipated loss of major functional domain due to fusion event.USP48-MAN1C1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
USP48-MAN1C1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across USP48 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MAN1C1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-8070-01AUSP48chr1

22109317

-MAN1C1chr1

26110154

+
ChimerDB4LUSCTCGA-85-8070USP48chr1

22109316

-MAN1C1chr1

26110153

+
ChimerDB4LUSCTCGA-85-8070USP48chr1

22109317

-MAN1C1chr1

26110154

+
ChimerDB4LUSCTCGA-85-8070-01AUSP48chr1

22109317

-MAN1C1chr1

26110154

+
ChimerDB4LUSCTCGA-85-8070-01AUSP48chr1

22109316

-MAN1C1chr1

26110153

+


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Fusion Gene ORF analysis for USP48-MAN1C1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000400301ENST00000374332USP48chr1

22109317

-MAN1C1chr1

26110154

+
Frame-shiftENST00000400301ENST00000263979USP48chr1

22109317

-MAN1C1chr1

26110154

+
5CDS-intronENST00000400301ENST00000473891USP48chr1

22109317

-MAN1C1chr1

26110154

+
5CDS-intronENST00000400301ENST00000374329USP48chr1

22109317

-MAN1C1chr1

26110154

+
In-frameENST00000308271ENST00000374332USP48chr1

22109317

-MAN1C1chr1

26110154

+
Frame-shiftENST00000308271ENST00000263979USP48chr1

22109317

-MAN1C1chr1

26110154

+
5CDS-intronENST00000308271ENST00000473891USP48chr1

22109317

-MAN1C1chr1

26110154

+
5CDS-intronENST00000308271ENST00000374329USP48chr1

22109317

-MAN1C1chr1

26110154

+
intron-3CDSENST00000374732ENST00000374332USP48chr1

22109317

-MAN1C1chr1

26110154

+
intron-3CDSENST00000374732ENST00000263979USP48chr1

22109317

-MAN1C1chr1

26110154

+
intron-intronENST00000374732ENST00000473891USP48chr1

22109317

-MAN1C1chr1

26110154

+
intron-intronENST00000374732ENST00000374329USP48chr1

22109317

-MAN1C1chr1

26110154

+
In-frameENST00000529637ENST00000374332USP48chr1

22109317

-MAN1C1chr1

26110154

+
Frame-shiftENST00000529637ENST00000263979USP48chr1

22109317

-MAN1C1chr1

26110154

+
5CDS-intronENST00000529637ENST00000473891USP48chr1

22109317

-MAN1C1chr1

26110154

+
5CDS-intronENST00000529637ENST00000374329USP48chr1

22109317

-MAN1C1chr1

26110154

+
intron-3CDSENST00000479177ENST00000374332USP48chr1

22109317

-MAN1C1chr1

26110154

+
intron-3CDSENST00000479177ENST00000263979USP48chr1

22109317

-MAN1C1chr1

26110154

+
intron-intronENST00000479177ENST00000473891USP48chr1

22109317

-MAN1C1chr1

26110154

+
intron-intronENST00000479177ENST00000374329USP48chr1

22109317

-MAN1C1chr1

26110154

+
In-frameENST00000421625ENST00000374332USP48chr1

22109317

-MAN1C1chr1

26110154

+
Frame-shiftENST00000421625ENST00000263979USP48chr1

22109317

-MAN1C1chr1

26110154

+
5CDS-intronENST00000421625ENST00000473891USP48chr1

22109317

-MAN1C1chr1

26110154

+
5CDS-intronENST00000421625ENST00000374329USP48chr1

22109317

-MAN1C1chr1

26110154

+
In-frameENST00000400301ENST00000374332USP48chr1

22109316

-MAN1C1chr1

26110153

+
Frame-shiftENST00000400301ENST00000263979USP48chr1

22109316

-MAN1C1chr1

26110153

+
5CDS-intronENST00000400301ENST00000473891USP48chr1

22109316

-MAN1C1chr1

26110153

+
5CDS-intronENST00000400301ENST00000374329USP48chr1

22109316

-MAN1C1chr1

26110153

+
In-frameENST00000308271ENST00000374332USP48chr1

22109316

-MAN1C1chr1

26110153

+
Frame-shiftENST00000308271ENST00000263979USP48chr1

22109316

-MAN1C1chr1

26110153

+
5CDS-intronENST00000308271ENST00000473891USP48chr1

22109316

-MAN1C1chr1

26110153

+
5CDS-intronENST00000308271ENST00000374329USP48chr1

22109316

-MAN1C1chr1

26110153

+
intron-3CDSENST00000374732ENST00000374332USP48chr1

22109316

-MAN1C1chr1

26110153

+
intron-3CDSENST00000374732ENST00000263979USP48chr1

22109316

-MAN1C1chr1

26110153

+
intron-intronENST00000374732ENST00000473891USP48chr1

22109316

-MAN1C1chr1

26110153

+
intron-intronENST00000374732ENST00000374329USP48chr1

22109316

-MAN1C1chr1

26110153

+
In-frameENST00000529637ENST00000374332USP48chr1

22109316

-MAN1C1chr1

26110153

+
Frame-shiftENST00000529637ENST00000263979USP48chr1

22109316

-MAN1C1chr1

26110153

+
5CDS-intronENST00000529637ENST00000473891USP48chr1

22109316

-MAN1C1chr1

26110153

+
5CDS-intronENST00000529637ENST00000374329USP48chr1

22109316

-MAN1C1chr1

26110153

+
intron-3CDSENST00000479177ENST00000374332USP48chr1

22109316

-MAN1C1chr1

26110153

+
intron-3CDSENST00000479177ENST00000263979USP48chr1

22109316

-MAN1C1chr1

26110153

+
intron-intronENST00000479177ENST00000473891USP48chr1

22109316

-MAN1C1chr1

26110153

+
intron-intronENST00000479177ENST00000374329USP48chr1

22109316

-MAN1C1chr1

26110153

+
In-frameENST00000421625ENST00000374332USP48chr1

22109316

-MAN1C1chr1

26110153

+
Frame-shiftENST00000421625ENST00000263979USP48chr1

22109316

-MAN1C1chr1

26110153

+
5CDS-intronENST00000421625ENST00000473891USP48chr1

22109316

-MAN1C1chr1

26110153

+
5CDS-intronENST00000421625ENST00000374329USP48chr1

22109316

-MAN1C1chr1

26110153

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400301USP48chr122109317-ENST00000374332MAN1C1chr126110154+2917372109498129
ENST00000308271USP48chr122109317-ENST00000374332MAN1C1chr126110154+3328783731147194
ENST00000529637USP48chr122109317-ENST00000374332MAN1C1chr126110154+271316814511077124
ENST00000421625USP48chr122109317-ENST00000374332MAN1C1chr126110154+3328783731147194
ENST00000400301USP48chr122109316-ENST00000374332MAN1C1chr126110153+2917372109498129
ENST00000308271USP48chr122109316-ENST00000374332MAN1C1chr126110153+3328783731147194
ENST00000529637USP48chr122109316-ENST00000374332MAN1C1chr126110153+271316814511077124
ENST00000421625USP48chr122109316-ENST00000374332MAN1C1chr126110153+3328783731147194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400301ENST00000374332USP48chr122109317-MAN1C1chr126110154+0.175686120.8243139
ENST00000308271ENST00000374332USP48chr122109317-MAN1C1chr126110154+0.41963990.5803601
ENST00000529637ENST00000374332USP48chr122109317-MAN1C1chr126110154+0.47605830.52394176
ENST00000421625ENST00000374332USP48chr122109317-MAN1C1chr126110154+0.41963990.5803601
ENST00000400301ENST00000374332USP48chr122109316-MAN1C1chr126110153+0.175686120.8243139
ENST00000308271ENST00000374332USP48chr122109316-MAN1C1chr126110153+0.41963990.5803601
ENST00000529637ENST00000374332USP48chr122109316-MAN1C1chr126110153+0.47605830.52394176
ENST00000421625ENST00000374332USP48chr122109316-MAN1C1chr126110153+0.41963990.5803601

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Fusion Genomic Features for USP48-MAN1C1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USP48chr122109316-MAN1C1chr126110153+2.59E-111
USP48chr122109316-MAN1C1chr126110153+2.59E-111
USP48chr122109316-MAN1C1chr126110153+2.59E-111
USP48chr122109316-MAN1C1chr126110153+2.59E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP48-MAN1C1


check button Go to

FGviewer for the breakpoints of chr1:22109317-chr1:26110154

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAN1C1

Q9NR34

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP48chr1:22109316chr1:26110153ENST00000308271-127460_55444.6666666666666641036.0DomainDUSP 1
HgeneUSP48chr1:22109316chr1:26110153ENST00000308271-127569_69144.6666666666666641036.0DomainDUSP 2
HgeneUSP48chr1:22109316chr1:26110153ENST00000308271-127711_82444.6666666666666641036.0DomainDUSP 3
HgeneUSP48chr1:22109316chr1:26110153ENST00000308271-12789_42144.6666666666666641036.0DomainNote=USP
HgeneUSP48chr1:22109316chr1:26110153ENST00000308271-127929_100944.6666666666666641036.0DomainUbiquitin-like
HgeneUSP48chr1:22109316chr1:26110153ENST00000400301-126460_55444.666666666666664984.0DomainDUSP 1
HgeneUSP48chr1:22109316chr1:26110153ENST00000400301-126569_69144.666666666666664984.0DomainDUSP 2
HgeneUSP48chr1:22109316chr1:26110153ENST00000400301-126711_82444.666666666666664984.0DomainDUSP 3
HgeneUSP48chr1:22109316chr1:26110153ENST00000400301-12689_42144.666666666666664984.0DomainNote=USP
HgeneUSP48chr1:22109316chr1:26110153ENST00000400301-126929_100944.666666666666664984.0DomainUbiquitin-like
HgeneUSP48chr1:22109316chr1:26110153ENST00000421625-111460_55444.666666666666664486.0DomainDUSP 1
HgeneUSP48chr1:22109316chr1:26110153ENST00000421625-111569_69144.666666666666664486.0DomainDUSP 2
HgeneUSP48chr1:22109316chr1:26110153ENST00000421625-111711_82444.666666666666664486.0DomainDUSP 3
HgeneUSP48chr1:22109316chr1:26110153ENST00000421625-11189_42144.666666666666664486.0DomainNote=USP
HgeneUSP48chr1:22109316chr1:26110153ENST00000421625-111929_100944.666666666666664486.0DomainUbiquitin-like
HgeneUSP48chr1:22109317chr1:26110154ENST00000308271-127460_55444.6666666666666641036.0DomainDUSP 1
HgeneUSP48chr1:22109317chr1:26110154ENST00000308271-127569_69144.6666666666666641036.0DomainDUSP 2
HgeneUSP48chr1:22109317chr1:26110154ENST00000308271-127711_82444.6666666666666641036.0DomainDUSP 3
HgeneUSP48chr1:22109317chr1:26110154ENST00000308271-12789_42144.6666666666666641036.0DomainNote=USP
HgeneUSP48chr1:22109317chr1:26110154ENST00000308271-127929_100944.6666666666666641036.0DomainUbiquitin-like
HgeneUSP48chr1:22109317chr1:26110154ENST00000400301-126460_55444.666666666666664984.0DomainDUSP 1
HgeneUSP48chr1:22109317chr1:26110154ENST00000400301-126569_69144.666666666666664984.0DomainDUSP 2
HgeneUSP48chr1:22109317chr1:26110154ENST00000400301-126711_82444.666666666666664984.0DomainDUSP 3
HgeneUSP48chr1:22109317chr1:26110154ENST00000400301-12689_42144.666666666666664984.0DomainNote=USP
HgeneUSP48chr1:22109317chr1:26110154ENST00000400301-126929_100944.666666666666664984.0DomainUbiquitin-like
HgeneUSP48chr1:22109317chr1:26110154ENST00000421625-111460_55444.666666666666664486.0DomainDUSP 1
HgeneUSP48chr1:22109317chr1:26110154ENST00000421625-111569_69144.666666666666664486.0DomainDUSP 2
HgeneUSP48chr1:22109317chr1:26110154ENST00000421625-111711_82444.666666666666664486.0DomainDUSP 3
HgeneUSP48chr1:22109317chr1:26110154ENST00000421625-11189_42144.666666666666664486.0DomainNote=USP
HgeneUSP48chr1:22109317chr1:26110154ENST00000421625-111929_100944.666666666666664486.0DomainUbiquitin-like
TgeneMAN1C1chr1:22109316chr1:26110153ENST0000037433210121_22588.6666666666666631.0Topological domainCytoplasmic
TgeneMAN1C1chr1:22109316chr1:26110153ENST00000374332101244_630588.6666666666666631.0Topological domainLumenal
TgeneMAN1C1chr1:22109317chr1:26110154ENST0000037433210121_22588.6666666666666631.0Topological domainCytoplasmic
TgeneMAN1C1chr1:22109317chr1:26110154ENST00000374332101244_630588.6666666666666631.0Topological domainLumenal
TgeneMAN1C1chr1:22109316chr1:26110153ENST00000374332101223_43588.6666666666666631.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneMAN1C1chr1:22109317chr1:26110154ENST00000374332101223_43588.6666666666666631.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for USP48-MAN1C1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000400301_ENST00000374332_TCGA-85-8070-01A_USP48_chr1_22109317_-_MAN1C1_chr1_26110154_length(transcript)=2917nt_BP=372nt
AACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCGGCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGT
GGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGAGCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTG
CAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGGCGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGC
CTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTCGCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCG
CGGCGTGTGCAGGTATCTCTATCTTCTGTTCTCTGAAGATGACTTGCTCTCCCTGGAAGACTGGGTGTTCAACACCGAGGCCCACCCACT
CCCGGTGAACCACTCAGACAGCTCCGGCAGAGCCTGGGGCAGACACTGACCCCATCTCCTGCCGCCGCCCTGGGGCCGCCGCAGGGATGC
CTTGCCTTTTCAGGATTTGAGACTGTTCTCAAAGGGATTGGGAACGAAGGCCCCATCTCGGGCAGACCCCCAGCAGATGTGTCGGACAAG
CAACTTCTTTTCCTCTGTGAGGAGACAAGACTTGGAGACTCAGCGATGTCAGGCCAGGGCCATGGCCACACTGGCCCACACATTCCTTTC
TACAGAGAATTTCTATGAAGCCCACTCACTTGCCATTCCAGGGCCAAAGGACCGGAGGTTTGCATATCCGCCCCTTGTATTTGATTTGCT
TCCTTTTGGTTTCTTGGTTTTTGTTTTTGCTTGATTTTGTCTTTTCTCTACAGTTTAGTTTTGTCACAATTACACATATAGTTTTCAAAA
TCATGCACTTTCTAAAATGGTGTCATCCTGAAAAACAAAACCCAGTGTTTGCACACACACAAAATCTTGACCCCGTTATCTATATTTTAA
ATGCTTTTTGCCCAACACTGACCCTATGTTCAACTTTGTGTCATTTACCTTATAATTTGAGGAGGGGTTTCCCTTTGGGCCTCAGTGTTA
CAAATTACTAGTGCTATTTTCATTATTATTGTAATGGAAAAATCTGTGGACTAGAATAAAAGAGTTTATTGAATAAGAAATATGATTGGG
CTCATTGCACATCAGTGACTCCTAGAAAAACCATTGCAATGTTACCATCAGAAATAATAATCAGCCAGCAGTTGATTTAAGGTATAATTT
AGTAAACGATTCCAACTTCTATTACCTCCCCTGAAATCGGTCCTGATATATTCGAGAAGCATGAGGCCAGCCCTTCAGATGCAGTTGTTT
ATTTATACTCAGGTTTAGATTGGGAAGAGGCCCAGGGAGGAGCAGCAACTTGCCTGAGGTCACACAGCCCAAAAAAGGCAAAGGAGAGTC
TCGCCCCTGCCGTCTCCTGGCCACCCCAGTTGAGTGTCCGTCTGTTCCATCATTCAGCAGATGCTTGGTGAGTGCCTGCAACGGACCAGA
CACTGGGCTAGAGGCCAGGGACACCGCTGAGAGTGAGACAGTCATAAGCCCTGCAGTCAAGGGGTCAAGAGGGGAGAAAGCGATGGTAAG
GGAAACTGACAAGTAAGTGAAGTGACTGCAGGTCATAGGAAATGCTACAAAGGAGATAGATAGACAGCTGAGGACCTACCCTACGGGGTC
AGGGAGGGCCTCTCTGGGCAGGTGACCTTCAAGCCAAGACCCAGAAGATAAAAAGGAGCAGCCGAAAGACTATCTGGCAGAAGAATGAAC
TTCCCATAACCCAGCCCCCTTTCCCACCCTCCCTGATGCCCTCCCTGGGAGGGGGCCTGAAACACTGGGGCTGTTGTGCAGAGCAAGGAG
CTCAGGTCCTAACACTGAAGTGACAGCTCTTCCTCCCCTGACCCTTTTTTTTTTTTGAGACCCAGAGTCTCGTTCAGTCGCCCAGGCTGG
AGTGCAGTGGTGCAATCTTGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAGTTCTCCTGCCTCAGCTTCCCCAGTAGCAGGGTGCG
TCACCACACCCGGCTAATTTTTTGTATTTTTAGTAAAGACGAGGTTTTGCCATGTTGCCTAGGCTGGTCTTGAACTCCTGAGCTCAGGTG
ATCCGCCCACCTCAGCCTCCCAAAGTGCGGGGATTACAGGCATGAGCCACCACACCCAGTCCTTTCCTGGCACATTTGCAGCTTGTCAAC
ACAGCGGAAATCACGGGAGAATGTTGAGCCCTTCCCTGGGCTCAGCTGCTTGCTCTGTTCATAAGCTTTAATAGCCCCCGGGGCTCTGGG
CCAGGTGACCCGGCTTTAAATCCCTGCTGTGTGAACTTAGGCAGGTACCTCCCCTCTCTGGGCTCTTCTTTTCCATCAAGCAGACAGAAA
ACCTCAACCCCACAAGGTTGCTGTGAGAAGAAGTGGGAAGCTGCTGGTTCCCTGGGCACAGGAAGTGCTTGTTCCTTGTTCTGGAGACTC
AAGACATTCCCAGAATCTTCTTAAGCAGAGCTGCTGGGGAGTAGCCCCTGTAGCAAGTACCATGCTCTTGACAGGCAGCATGAGAGCGTG
ACTCCCATGACCCACCTGTGCTCAAAAAAAAAAAAAAAAAAAAGCAAACCAGGAAAACTGACTACACAAACATTGTAGAAAGATTAGAAA
ATAGAAGCAGAAAGAAGACTCATTGGCCATCCCACTCTCTGGGGTGAATACTGTTATATTTTCTTCTAGGCCTTTTTCTATGAATATATA
GAATATAGATTTTGCCACCGTGGTATCCTACTATGCACACTGTTTTCTTATAATCTGCTTTTGCACTTAACTGTACATTGTGAACCTCTT

>In-frame_ENST00000400301_ENST00000374332_TCGA-85-8070-01A_USP48_chr1_22109317_-_MAN1C1_chr1_26110154_length(amino acids)=129AA_start in transcript=109_stop in transcript=498
MASCLKERQVLLAGRWRSPLGRRCRPRRRLRRSGSGGVPGAKAMAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVCRYL

--------------------------------------------------------------
>In-frame_ENST00000308271_ENST00000374332_TCGA-85-8070-01A_USP48_chr1_22109317_-_MAN1C1_chr1_26110154_length(transcript)=3328nt_BP=783nt
GCTCGGGAAAGGGGTTCGGAACCGGTCTAGGCTCAAGTTAAATCTCCCTCTAAAGAGCCAACACTGGTTTCTTTGGCGACTCGGTTTCTA
CTCTAAACAGGTCCCGCTCCACAGTCTGGGCGGGCCTGTGTGTGCGTTGAGTAGCCTCTAGCGTGAAAACTTCATGGTTAAAAGGGAAGT
ACCGGAGGCAAGAAATAGCTTTCGAGGCACTGGTTTGTTAGAGTAGTGGTACGTAGTGCGCCGCCCTGAACGGGGGCTGAGACGCTGCTT
TTCCAGAAGTGCCAGTGAGGACGTGGCAAGACCGCCTCGGACGTACGCTTCCTCTACCTCAGCCCGTCGGGTTAGGGGCGCGGGAGGCGC
AGAGGCTGCTGGGAACGCGCATGCGCTCAGCGCGGCGGGGAGTCCACCTTTAACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCG
GCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGTGGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGA
GCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTGCAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGG
CGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTC
GCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGTATCTCTATCTTCTGTTCTCTGAAGA
TGACTTGCTCTCCCTGGAAGACTGGGTGTTCAACACCGAGGCCCACCCACTCCCGGTGAACCACTCAGACAGCTCCGGCAGAGCCTGGGG
CAGACACTGACCCCATCTCCTGCCGCCGCCCTGGGGCCGCCGCAGGGATGCCTTGCCTTTTCAGGATTTGAGACTGTTCTCAAAGGGATT
GGGAACGAAGGCCCCATCTCGGGCAGACCCCCAGCAGATGTGTCGGACAAGCAACTTCTTTTCCTCTGTGAGGAGACAAGACTTGGAGAC
TCAGCGATGTCAGGCCAGGGCCATGGCCACACTGGCCCACACATTCCTTTCTACAGAGAATTTCTATGAAGCCCACTCACTTGCCATTCC
AGGGCCAAAGGACCGGAGGTTTGCATATCCGCCCCTTGTATTTGATTTGCTTCCTTTTGGTTTCTTGGTTTTTGTTTTTGCTTGATTTTG
TCTTTTCTCTACAGTTTAGTTTTGTCACAATTACACATATAGTTTTCAAAATCATGCACTTTCTAAAATGGTGTCATCCTGAAAAACAAA
ACCCAGTGTTTGCACACACACAAAATCTTGACCCCGTTATCTATATTTTAAATGCTTTTTGCCCAACACTGACCCTATGTTCAACTTTGT
GTCATTTACCTTATAATTTGAGGAGGGGTTTCCCTTTGGGCCTCAGTGTTACAAATTACTAGTGCTATTTTCATTATTATTGTAATGGAA
AAATCTGTGGACTAGAATAAAAGAGTTTATTGAATAAGAAATATGATTGGGCTCATTGCACATCAGTGACTCCTAGAAAAACCATTGCAA
TGTTACCATCAGAAATAATAATCAGCCAGCAGTTGATTTAAGGTATAATTTAGTAAACGATTCCAACTTCTATTACCTCCCCTGAAATCG
GTCCTGATATATTCGAGAAGCATGAGGCCAGCCCTTCAGATGCAGTTGTTTATTTATACTCAGGTTTAGATTGGGAAGAGGCCCAGGGAG
GAGCAGCAACTTGCCTGAGGTCACACAGCCCAAAAAAGGCAAAGGAGAGTCTCGCCCCTGCCGTCTCCTGGCCACCCCAGTTGAGTGTCC
GTCTGTTCCATCATTCAGCAGATGCTTGGTGAGTGCCTGCAACGGACCAGACACTGGGCTAGAGGCCAGGGACACCGCTGAGAGTGAGAC
AGTCATAAGCCCTGCAGTCAAGGGGTCAAGAGGGGAGAAAGCGATGGTAAGGGAAACTGACAAGTAAGTGAAGTGACTGCAGGTCATAGG
AAATGCTACAAAGGAGATAGATAGACAGCTGAGGACCTACCCTACGGGGTCAGGGAGGGCCTCTCTGGGCAGGTGACCTTCAAGCCAAGA
CCCAGAAGATAAAAAGGAGCAGCCGAAAGACTATCTGGCAGAAGAATGAACTTCCCATAACCCAGCCCCCTTTCCCACCCTCCCTGATGC
CCTCCCTGGGAGGGGGCCTGAAACACTGGGGCTGTTGTGCAGAGCAAGGAGCTCAGGTCCTAACACTGAAGTGACAGCTCTTCCTCCCCT
GACCCTTTTTTTTTTTTGAGACCCAGAGTCTCGTTCAGTCGCCCAGGCTGGAGTGCAGTGGTGCAATCTTGGCTCACTGCAACCTCCACC
TCCTGGGTTCAAGCAGTTCTCCTGCCTCAGCTTCCCCAGTAGCAGGGTGCGTCACCACACCCGGCTAATTTTTTGTATTTTTAGTAAAGA
CGAGGTTTTGCCATGTTGCCTAGGCTGGTCTTGAACTCCTGAGCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAGTGCGGGGATTACAG
GCATGAGCCACCACACCCAGTCCTTTCCTGGCACATTTGCAGCTTGTCAACACAGCGGAAATCACGGGAGAATGTTGAGCCCTTCCCTGG
GCTCAGCTGCTTGCTCTGTTCATAAGCTTTAATAGCCCCCGGGGCTCTGGGCCAGGTGACCCGGCTTTAAATCCCTGCTGTGTGAACTTA
GGCAGGTACCTCCCCTCTCTGGGCTCTTCTTTTCCATCAAGCAGACAGAAAACCTCAACCCCACAAGGTTGCTGTGAGAAGAAGTGGGAA
GCTGCTGGTTCCCTGGGCACAGGAAGTGCTTGTTCCTTGTTCTGGAGACTCAAGACATTCCCAGAATCTTCTTAAGCAGAGCTGCTGGGG
AGTAGCCCCTGTAGCAAGTACCATGCTCTTGACAGGCAGCATGAGAGCGTGACTCCCATGACCCACCTGTGCTCAAAAAAAAAAAAAAAA
AAAAGCAAACCAGGAAAACTGACTACACAAACATTGTAGAAAGATTAGAAAATAGAAGCAGAAAGAAGACTCATTGGCCATCCCACTCTC
TGGGGTGAATACTGTTATATTTTCTTCTAGGCCTTTTTCTATGAATATATAGAATATAGATTTTGCCACCGTGGTATCCTACTATGCACA

>In-frame_ENST00000308271_ENST00000374332_TCGA-85-8070-01A_USP48_chr1_22109317_-_MAN1C1_chr1_26110154_length(amino acids)=194AA_start in transcript=731_stop in transcript=147
MCSCDTSSGRTVSAQRQAAFSSCSRGAMALAPGTPPEPDRRSRRRGLHRRPNGLRHLPARRTWRSFRQLASQSPVRATAAAPARARPARP
AAKRRRRHPTHPAPADVKGGLPAALSACAFPAASAPPAPLTRRAEVEEAYVRGGLATSSLALLEKQRLSPRSGRRTTYHYSNKPVPRKLF

--------------------------------------------------------------
>In-frame_ENST00000529637_ENST00000374332_TCGA-85-8070-01A_USP48_chr1_22109317_-_MAN1C1_chr1_26110154_length(transcript)=2713nt_BP=168nt
GTCTGGCTCGGGAGGCGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCG
GCCCGAGGAGGTGTCGCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGTATCTCTATCT
TCTGTTCTCTGAAGATGACTTGCTCTCCCTGGAAGACTGGGTGTTCAACACCGAGGCCCACCCACTCCCGGTGAACCACTCAGACAGCTC
CGGCAGAGCCTGGGGCAGACACTGACCCCATCTCCTGCCGCCGCCCTGGGGCCGCCGCAGGGATGCCTTGCCTTTTCAGGATTTGAGACT
GTTCTCAAAGGGATTGGGAACGAAGGCCCCATCTCGGGCAGACCCCCAGCAGATGTGTCGGACAAGCAACTTCTTTTCCTCTGTGAGGAG
ACAAGACTTGGAGACTCAGCGATGTCAGGCCAGGGCCATGGCCACACTGGCCCACACATTCCTTTCTACAGAGAATTTCTATGAAGCCCA
CTCACTTGCCATTCCAGGGCCAAAGGACCGGAGGTTTGCATATCCGCCCCTTGTATTTGATTTGCTTCCTTTTGGTTTCTTGGTTTTTGT
TTTTGCTTGATTTTGTCTTTTCTCTACAGTTTAGTTTTGTCACAATTACACATATAGTTTTCAAAATCATGCACTTTCTAAAATGGTGTC
ATCCTGAAAAACAAAACCCAGTGTTTGCACACACACAAAATCTTGACCCCGTTATCTATATTTTAAATGCTTTTTGCCCAACACTGACCC
TATGTTCAACTTTGTGTCATTTACCTTATAATTTGAGGAGGGGTTTCCCTTTGGGCCTCAGTGTTACAAATTACTAGTGCTATTTTCATT
ATTATTGTAATGGAAAAATCTGTGGACTAGAATAAAAGAGTTTATTGAATAAGAAATATGATTGGGCTCATTGCACATCAGTGACTCCTA
GAAAAACCATTGCAATGTTACCATCAGAAATAATAATCAGCCAGCAGTTGATTTAAGGTATAATTTAGTAAACGATTCCAACTTCTATTA
CCTCCCCTGAAATCGGTCCTGATATATTCGAGAAGCATGAGGCCAGCCCTTCAGATGCAGTTGTTTATTTATACTCAGGTTTAGATTGGG
AAGAGGCCCAGGGAGGAGCAGCAACTTGCCTGAGGTCACACAGCCCAAAAAAGGCAAAGGAGAGTCTCGCCCCTGCCGTCTCCTGGCCAC
CCCAGTTGAGTGTCCGTCTGTTCCATCATTCAGCAGATGCTTGGTGAGTGCCTGCAACGGACCAGACACTGGGCTAGAGGCCAGGGACAC
CGCTGAGAGTGAGACAGTCATAAGCCCTGCAGTCAAGGGGTCAAGAGGGGAGAAAGCGATGGTAAGGGAAACTGACAAGTAAGTGAAGTG
ACTGCAGGTCATAGGAAATGCTACAAAGGAGATAGATAGACAGCTGAGGACCTACCCTACGGGGTCAGGGAGGGCCTCTCTGGGCAGGTG
ACCTTCAAGCCAAGACCCAGAAGATAAAAAGGAGCAGCCGAAAGACTATCTGGCAGAAGAATGAACTTCCCATAACCCAGCCCCCTTTCC
CACCCTCCCTGATGCCCTCCCTGGGAGGGGGCCTGAAACACTGGGGCTGTTGTGCAGAGCAAGGAGCTCAGGTCCTAACACTGAAGTGAC
AGCTCTTCCTCCCCTGACCCTTTTTTTTTTTTGAGACCCAGAGTCTCGTTCAGTCGCCCAGGCTGGAGTGCAGTGGTGCAATCTTGGCTC
ACTGCAACCTCCACCTCCTGGGTTCAAGCAGTTCTCCTGCCTCAGCTTCCCCAGTAGCAGGGTGCGTCACCACACCCGGCTAATTTTTTG
TATTTTTAGTAAAGACGAGGTTTTGCCATGTTGCCTAGGCTGGTCTTGAACTCCTGAGCTCAGGTGATCCGCCCACCTCAGCCTCCCAAA
GTGCGGGGATTACAGGCATGAGCCACCACACCCAGTCCTTTCCTGGCACATTTGCAGCTTGTCAACACAGCGGAAATCACGGGAGAATGT
TGAGCCCTTCCCTGGGCTCAGCTGCTTGCTCTGTTCATAAGCTTTAATAGCCCCCGGGGCTCTGGGCCAGGTGACCCGGCTTTAAATCCC
TGCTGTGTGAACTTAGGCAGGTACCTCCCCTCTCTGGGCTCTTCTTTTCCATCAAGCAGACAGAAAACCTCAACCCCACAAGGTTGCTGT
GAGAAGAAGTGGGAAGCTGCTGGTTCCCTGGGCACAGGAAGTGCTTGTTCCTTGTTCTGGAGACTCAAGACATTCCCAGAATCTTCTTAA
GCAGAGCTGCTGGGGAGTAGCCCCTGTAGCAAGTACCATGCTCTTGACAGGCAGCATGAGAGCGTGACTCCCATGACCCACCTGTGCTCA
AAAAAAAAAAAAAAAAAAAGCAAACCAGGAAAACTGACTACACAAACATTGTAGAAAGATTAGAAAATAGAAGCAGAAAGAAGACTCATT
GGCCATCCCACTCTCTGGGGTGAATACTGTTATATTTTCTTCTAGGCCTTTTTCTATGAATATATAGAATATAGATTTTGCCACCGTGGT
ATCCTACTATGCACACTGTTTTCTTATAATCTGCTTTTGCACTTAACTGTACATTGTGAACCTCTTTCCATGTCAACAAATACATGTTTA

>In-frame_ENST00000529637_ENST00000374332_TCGA-85-8070-01A_USP48_chr1_22109317_-_MAN1C1_chr1_26110154_length(amino acids)=124AA_start in transcript=1451_stop in transcript=1077
MTCSHFTYLSVSLTIAFSPLDPLTAGLMTVSLSAVSLASSPVSGPLQALTKHLLNDGTDGHSTGVARRRQGRDSPLPFLGCVTSGKLLLL

--------------------------------------------------------------
>In-frame_ENST00000421625_ENST00000374332_TCGA-85-8070-01A_USP48_chr1_22109317_-_MAN1C1_chr1_26110154_length(transcript)=3328nt_BP=783nt
GCTCGGGAAAGGGGTTCGGAACCGGTCTAGGCTCAAGTTAAATCTCCCTCTAAAGAGCCAACACTGGTTTCTTTGGCGACTCGGTTTCTA
CTCTAAACAGGTCCCGCTCCACAGTCTGGGCGGGCCTGTGTGTGCGTTGAGTAGCCTCTAGCGTGAAAACTTCATGGTTAAAAGGGAAGT
ACCGGAGGCAAGAAATAGCTTTCGAGGCACTGGTTTGTTAGAGTAGTGGTACGTAGTGCGCCGCCCTGAACGGGGGCTGAGACGCTGCTT
TTCCAGAAGTGCCAGTGAGGACGTGGCAAGACCGCCTCGGACGTACGCTTCCTCTACCTCAGCCCGTCGGGTTAGGGGCGCGGGAGGCGC
AGAGGCTGCTGGGAACGCGCATGCGCTCAGCGCGGCGGGGAGTCCACCTTTAACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCG
GCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGTGGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGA
GCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTGCAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGG
CGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTC
GCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGTATCTCTATCTTCTGTTCTCTGAAGA
TGACTTGCTCTCCCTGGAAGACTGGGTGTTCAACACCGAGGCCCACCCACTCCCGGTGAACCACTCAGACAGCTCCGGCAGAGCCTGGGG
CAGACACTGACCCCATCTCCTGCCGCCGCCCTGGGGCCGCCGCAGGGATGCCTTGCCTTTTCAGGATTTGAGACTGTTCTCAAAGGGATT
GGGAACGAAGGCCCCATCTCGGGCAGACCCCCAGCAGATGTGTCGGACAAGCAACTTCTTTTCCTCTGTGAGGAGACAAGACTTGGAGAC
TCAGCGATGTCAGGCCAGGGCCATGGCCACACTGGCCCACACATTCCTTTCTACAGAGAATTTCTATGAAGCCCACTCACTTGCCATTCC
AGGGCCAAAGGACCGGAGGTTTGCATATCCGCCCCTTGTATTTGATTTGCTTCCTTTTGGTTTCTTGGTTTTTGTTTTTGCTTGATTTTG
TCTTTTCTCTACAGTTTAGTTTTGTCACAATTACACATATAGTTTTCAAAATCATGCACTTTCTAAAATGGTGTCATCCTGAAAAACAAA
ACCCAGTGTTTGCACACACACAAAATCTTGACCCCGTTATCTATATTTTAAATGCTTTTTGCCCAACACTGACCCTATGTTCAACTTTGT
GTCATTTACCTTATAATTTGAGGAGGGGTTTCCCTTTGGGCCTCAGTGTTACAAATTACTAGTGCTATTTTCATTATTATTGTAATGGAA
AAATCTGTGGACTAGAATAAAAGAGTTTATTGAATAAGAAATATGATTGGGCTCATTGCACATCAGTGACTCCTAGAAAAACCATTGCAA
TGTTACCATCAGAAATAATAATCAGCCAGCAGTTGATTTAAGGTATAATTTAGTAAACGATTCCAACTTCTATTACCTCCCCTGAAATCG
GTCCTGATATATTCGAGAAGCATGAGGCCAGCCCTTCAGATGCAGTTGTTTATTTATACTCAGGTTTAGATTGGGAAGAGGCCCAGGGAG
GAGCAGCAACTTGCCTGAGGTCACACAGCCCAAAAAAGGCAAAGGAGAGTCTCGCCCCTGCCGTCTCCTGGCCACCCCAGTTGAGTGTCC
GTCTGTTCCATCATTCAGCAGATGCTTGGTGAGTGCCTGCAACGGACCAGACACTGGGCTAGAGGCCAGGGACACCGCTGAGAGTGAGAC
AGTCATAAGCCCTGCAGTCAAGGGGTCAAGAGGGGAGAAAGCGATGGTAAGGGAAACTGACAAGTAAGTGAAGTGACTGCAGGTCATAGG
AAATGCTACAAAGGAGATAGATAGACAGCTGAGGACCTACCCTACGGGGTCAGGGAGGGCCTCTCTGGGCAGGTGACCTTCAAGCCAAGA
CCCAGAAGATAAAAAGGAGCAGCCGAAAGACTATCTGGCAGAAGAATGAACTTCCCATAACCCAGCCCCCTTTCCCACCCTCCCTGATGC
CCTCCCTGGGAGGGGGCCTGAAACACTGGGGCTGTTGTGCAGAGCAAGGAGCTCAGGTCCTAACACTGAAGTGACAGCTCTTCCTCCCCT
GACCCTTTTTTTTTTTTGAGACCCAGAGTCTCGTTCAGTCGCCCAGGCTGGAGTGCAGTGGTGCAATCTTGGCTCACTGCAACCTCCACC
TCCTGGGTTCAAGCAGTTCTCCTGCCTCAGCTTCCCCAGTAGCAGGGTGCGTCACCACACCCGGCTAATTTTTTGTATTTTTAGTAAAGA
CGAGGTTTTGCCATGTTGCCTAGGCTGGTCTTGAACTCCTGAGCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAGTGCGGGGATTACAG
GCATGAGCCACCACACCCAGTCCTTTCCTGGCACATTTGCAGCTTGTCAACACAGCGGAAATCACGGGAGAATGTTGAGCCCTTCCCTGG
GCTCAGCTGCTTGCTCTGTTCATAAGCTTTAATAGCCCCCGGGGCTCTGGGCCAGGTGACCCGGCTTTAAATCCCTGCTGTGTGAACTTA
GGCAGGTACCTCCCCTCTCTGGGCTCTTCTTTTCCATCAAGCAGACAGAAAACCTCAACCCCACAAGGTTGCTGTGAGAAGAAGTGGGAA
GCTGCTGGTTCCCTGGGCACAGGAAGTGCTTGTTCCTTGTTCTGGAGACTCAAGACATTCCCAGAATCTTCTTAAGCAGAGCTGCTGGGG
AGTAGCCCCTGTAGCAAGTACCATGCTCTTGACAGGCAGCATGAGAGCGTGACTCCCATGACCCACCTGTGCTCAAAAAAAAAAAAAAAA
AAAAGCAAACCAGGAAAACTGACTACACAAACATTGTAGAAAGATTAGAAAATAGAAGCAGAAAGAAGACTCATTGGCCATCCCACTCTC
TGGGGTGAATACTGTTATATTTTCTTCTAGGCCTTTTTCTATGAATATATAGAATATAGATTTTGCCACCGTGGTATCCTACTATGCACA

>In-frame_ENST00000421625_ENST00000374332_TCGA-85-8070-01A_USP48_chr1_22109317_-_MAN1C1_chr1_26110154_length(amino acids)=194AA_start in transcript=731_stop in transcript=147
MCSCDTSSGRTVSAQRQAAFSSCSRGAMALAPGTPPEPDRRSRRRGLHRRPNGLRHLPARRTWRSFRQLASQSPVRATAAAPARARPARP
AAKRRRRHPTHPAPADVKGGLPAALSACAFPAASAPPAPLTRRAEVEEAYVRGGLATSSLALLEKQRLSPRSGRRTTYHYSNKPVPRKLF

--------------------------------------------------------------
>In-frame_ENST00000400301_ENST00000374332_TCGA-85-8070_USP48_chr1_22109316_-_MAN1C1_chr1_26110153_length(transcript)=2917nt_BP=372nt
AACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCGGCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGT
GGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGAGCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTG
CAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGGCGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGC
CTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTCGCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCG
CGGCGTGTGCAGGTATCTCTATCTTCTGTTCTCTGAAGATGACTTGCTCTCCCTGGAAGACTGGGTGTTCAACACCGAGGCCCACCCACT
CCCGGTGAACCACTCAGACAGCTCCGGCAGAGCCTGGGGCAGACACTGACCCCATCTCCTGCCGCCGCCCTGGGGCCGCCGCAGGGATGC
CTTGCCTTTTCAGGATTTGAGACTGTTCTCAAAGGGATTGGGAACGAAGGCCCCATCTCGGGCAGACCCCCAGCAGATGTGTCGGACAAG
CAACTTCTTTTCCTCTGTGAGGAGACAAGACTTGGAGACTCAGCGATGTCAGGCCAGGGCCATGGCCACACTGGCCCACACATTCCTTTC
TACAGAGAATTTCTATGAAGCCCACTCACTTGCCATTCCAGGGCCAAAGGACCGGAGGTTTGCATATCCGCCCCTTGTATTTGATTTGCT
TCCTTTTGGTTTCTTGGTTTTTGTTTTTGCTTGATTTTGTCTTTTCTCTACAGTTTAGTTTTGTCACAATTACACATATAGTTTTCAAAA
TCATGCACTTTCTAAAATGGTGTCATCCTGAAAAACAAAACCCAGTGTTTGCACACACACAAAATCTTGACCCCGTTATCTATATTTTAA
ATGCTTTTTGCCCAACACTGACCCTATGTTCAACTTTGTGTCATTTACCTTATAATTTGAGGAGGGGTTTCCCTTTGGGCCTCAGTGTTA
CAAATTACTAGTGCTATTTTCATTATTATTGTAATGGAAAAATCTGTGGACTAGAATAAAAGAGTTTATTGAATAAGAAATATGATTGGG
CTCATTGCACATCAGTGACTCCTAGAAAAACCATTGCAATGTTACCATCAGAAATAATAATCAGCCAGCAGTTGATTTAAGGTATAATTT
AGTAAACGATTCCAACTTCTATTACCTCCCCTGAAATCGGTCCTGATATATTCGAGAAGCATGAGGCCAGCCCTTCAGATGCAGTTGTTT
ATTTATACTCAGGTTTAGATTGGGAAGAGGCCCAGGGAGGAGCAGCAACTTGCCTGAGGTCACACAGCCCAAAAAAGGCAAAGGAGAGTC
TCGCCCCTGCCGTCTCCTGGCCACCCCAGTTGAGTGTCCGTCTGTTCCATCATTCAGCAGATGCTTGGTGAGTGCCTGCAACGGACCAGA
CACTGGGCTAGAGGCCAGGGACACCGCTGAGAGTGAGACAGTCATAAGCCCTGCAGTCAAGGGGTCAAGAGGGGAGAAAGCGATGGTAAG
GGAAACTGACAAGTAAGTGAAGTGACTGCAGGTCATAGGAAATGCTACAAAGGAGATAGATAGACAGCTGAGGACCTACCCTACGGGGTC
AGGGAGGGCCTCTCTGGGCAGGTGACCTTCAAGCCAAGACCCAGAAGATAAAAAGGAGCAGCCGAAAGACTATCTGGCAGAAGAATGAAC
TTCCCATAACCCAGCCCCCTTTCCCACCCTCCCTGATGCCCTCCCTGGGAGGGGGCCTGAAACACTGGGGCTGTTGTGCAGAGCAAGGAG
CTCAGGTCCTAACACTGAAGTGACAGCTCTTCCTCCCCTGACCCTTTTTTTTTTTTGAGACCCAGAGTCTCGTTCAGTCGCCCAGGCTGG
AGTGCAGTGGTGCAATCTTGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAGTTCTCCTGCCTCAGCTTCCCCAGTAGCAGGGTGCG
TCACCACACCCGGCTAATTTTTTGTATTTTTAGTAAAGACGAGGTTTTGCCATGTTGCCTAGGCTGGTCTTGAACTCCTGAGCTCAGGTG
ATCCGCCCACCTCAGCCTCCCAAAGTGCGGGGATTACAGGCATGAGCCACCACACCCAGTCCTTTCCTGGCACATTTGCAGCTTGTCAAC
ACAGCGGAAATCACGGGAGAATGTTGAGCCCTTCCCTGGGCTCAGCTGCTTGCTCTGTTCATAAGCTTTAATAGCCCCCGGGGCTCTGGG
CCAGGTGACCCGGCTTTAAATCCCTGCTGTGTGAACTTAGGCAGGTACCTCCCCTCTCTGGGCTCTTCTTTTCCATCAAGCAGACAGAAA
ACCTCAACCCCACAAGGTTGCTGTGAGAAGAAGTGGGAAGCTGCTGGTTCCCTGGGCACAGGAAGTGCTTGTTCCTTGTTCTGGAGACTC
AAGACATTCCCAGAATCTTCTTAAGCAGAGCTGCTGGGGAGTAGCCCCTGTAGCAAGTACCATGCTCTTGACAGGCAGCATGAGAGCGTG
ACTCCCATGACCCACCTGTGCTCAAAAAAAAAAAAAAAAAAAAGCAAACCAGGAAAACTGACTACACAAACATTGTAGAAAGATTAGAAA
ATAGAAGCAGAAAGAAGACTCATTGGCCATCCCACTCTCTGGGGTGAATACTGTTATATTTTCTTCTAGGCCTTTTTCTATGAATATATA
GAATATAGATTTTGCCACCGTGGTATCCTACTATGCACACTGTTTTCTTATAATCTGCTTTTGCACTTAACTGTACATTGTGAACCTCTT

>In-frame_ENST00000400301_ENST00000374332_TCGA-85-8070_USP48_chr1_22109316_-_MAN1C1_chr1_26110153_length(amino acids)=129AA_start in transcript=109_stop in transcript=498
MASCLKERQVLLAGRWRSPLGRRCRPRRRLRRSGSGGVPGAKAMAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVCRYL

--------------------------------------------------------------
>In-frame_ENST00000308271_ENST00000374332_TCGA-85-8070_USP48_chr1_22109316_-_MAN1C1_chr1_26110153_length(transcript)=3328nt_BP=783nt
GCTCGGGAAAGGGGTTCGGAACCGGTCTAGGCTCAAGTTAAATCTCCCTCTAAAGAGCCAACACTGGTTTCTTTGGCGACTCGGTTTCTA
CTCTAAACAGGTCCCGCTCCACAGTCTGGGCGGGCCTGTGTGTGCGTTGAGTAGCCTCTAGCGTGAAAACTTCATGGTTAAAAGGGAAGT
ACCGGAGGCAAGAAATAGCTTTCGAGGCACTGGTTTGTTAGAGTAGTGGTACGTAGTGCGCCGCCCTGAACGGGGGCTGAGACGCTGCTT
TTCCAGAAGTGCCAGTGAGGACGTGGCAAGACCGCCTCGGACGTACGCTTCCTCTACCTCAGCCCGTCGGGTTAGGGGCGCGGGAGGCGC
AGAGGCTGCTGGGAACGCGCATGCGCTCAGCGCGGCGGGGAGTCCACCTTTAACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCG
GCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGTGGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGA
GCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTGCAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGG
CGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTC
GCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGTATCTCTATCTTCTGTTCTCTGAAGA
TGACTTGCTCTCCCTGGAAGACTGGGTGTTCAACACCGAGGCCCACCCACTCCCGGTGAACCACTCAGACAGCTCCGGCAGAGCCTGGGG
CAGACACTGACCCCATCTCCTGCCGCCGCCCTGGGGCCGCCGCAGGGATGCCTTGCCTTTTCAGGATTTGAGACTGTTCTCAAAGGGATT
GGGAACGAAGGCCCCATCTCGGGCAGACCCCCAGCAGATGTGTCGGACAAGCAACTTCTTTTCCTCTGTGAGGAGACAAGACTTGGAGAC
TCAGCGATGTCAGGCCAGGGCCATGGCCACACTGGCCCACACATTCCTTTCTACAGAGAATTTCTATGAAGCCCACTCACTTGCCATTCC
AGGGCCAAAGGACCGGAGGTTTGCATATCCGCCCCTTGTATTTGATTTGCTTCCTTTTGGTTTCTTGGTTTTTGTTTTTGCTTGATTTTG
TCTTTTCTCTACAGTTTAGTTTTGTCACAATTACACATATAGTTTTCAAAATCATGCACTTTCTAAAATGGTGTCATCCTGAAAAACAAA
ACCCAGTGTTTGCACACACACAAAATCTTGACCCCGTTATCTATATTTTAAATGCTTTTTGCCCAACACTGACCCTATGTTCAACTTTGT
GTCATTTACCTTATAATTTGAGGAGGGGTTTCCCTTTGGGCCTCAGTGTTACAAATTACTAGTGCTATTTTCATTATTATTGTAATGGAA
AAATCTGTGGACTAGAATAAAAGAGTTTATTGAATAAGAAATATGATTGGGCTCATTGCACATCAGTGACTCCTAGAAAAACCATTGCAA
TGTTACCATCAGAAATAATAATCAGCCAGCAGTTGATTTAAGGTATAATTTAGTAAACGATTCCAACTTCTATTACCTCCCCTGAAATCG
GTCCTGATATATTCGAGAAGCATGAGGCCAGCCCTTCAGATGCAGTTGTTTATTTATACTCAGGTTTAGATTGGGAAGAGGCCCAGGGAG
GAGCAGCAACTTGCCTGAGGTCACACAGCCCAAAAAAGGCAAAGGAGAGTCTCGCCCCTGCCGTCTCCTGGCCACCCCAGTTGAGTGTCC
GTCTGTTCCATCATTCAGCAGATGCTTGGTGAGTGCCTGCAACGGACCAGACACTGGGCTAGAGGCCAGGGACACCGCTGAGAGTGAGAC
AGTCATAAGCCCTGCAGTCAAGGGGTCAAGAGGGGAGAAAGCGATGGTAAGGGAAACTGACAAGTAAGTGAAGTGACTGCAGGTCATAGG
AAATGCTACAAAGGAGATAGATAGACAGCTGAGGACCTACCCTACGGGGTCAGGGAGGGCCTCTCTGGGCAGGTGACCTTCAAGCCAAGA
CCCAGAAGATAAAAAGGAGCAGCCGAAAGACTATCTGGCAGAAGAATGAACTTCCCATAACCCAGCCCCCTTTCCCACCCTCCCTGATGC
CCTCCCTGGGAGGGGGCCTGAAACACTGGGGCTGTTGTGCAGAGCAAGGAGCTCAGGTCCTAACACTGAAGTGACAGCTCTTCCTCCCCT
GACCCTTTTTTTTTTTTGAGACCCAGAGTCTCGTTCAGTCGCCCAGGCTGGAGTGCAGTGGTGCAATCTTGGCTCACTGCAACCTCCACC
TCCTGGGTTCAAGCAGTTCTCCTGCCTCAGCTTCCCCAGTAGCAGGGTGCGTCACCACACCCGGCTAATTTTTTGTATTTTTAGTAAAGA
CGAGGTTTTGCCATGTTGCCTAGGCTGGTCTTGAACTCCTGAGCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAGTGCGGGGATTACAG
GCATGAGCCACCACACCCAGTCCTTTCCTGGCACATTTGCAGCTTGTCAACACAGCGGAAATCACGGGAGAATGTTGAGCCCTTCCCTGG
GCTCAGCTGCTTGCTCTGTTCATAAGCTTTAATAGCCCCCGGGGCTCTGGGCCAGGTGACCCGGCTTTAAATCCCTGCTGTGTGAACTTA
GGCAGGTACCTCCCCTCTCTGGGCTCTTCTTTTCCATCAAGCAGACAGAAAACCTCAACCCCACAAGGTTGCTGTGAGAAGAAGTGGGAA
GCTGCTGGTTCCCTGGGCACAGGAAGTGCTTGTTCCTTGTTCTGGAGACTCAAGACATTCCCAGAATCTTCTTAAGCAGAGCTGCTGGGG
AGTAGCCCCTGTAGCAAGTACCATGCTCTTGACAGGCAGCATGAGAGCGTGACTCCCATGACCCACCTGTGCTCAAAAAAAAAAAAAAAA
AAAAGCAAACCAGGAAAACTGACTACACAAACATTGTAGAAAGATTAGAAAATAGAAGCAGAAAGAAGACTCATTGGCCATCCCACTCTC
TGGGGTGAATACTGTTATATTTTCTTCTAGGCCTTTTTCTATGAATATATAGAATATAGATTTTGCCACCGTGGTATCCTACTATGCACA

>In-frame_ENST00000308271_ENST00000374332_TCGA-85-8070_USP48_chr1_22109316_-_MAN1C1_chr1_26110153_length(amino acids)=194AA_start in transcript=731_stop in transcript=147
MCSCDTSSGRTVSAQRQAAFSSCSRGAMALAPGTPPEPDRRSRRRGLHRRPNGLRHLPARRTWRSFRQLASQSPVRATAAAPARARPARP
AAKRRRRHPTHPAPADVKGGLPAALSACAFPAASAPPAPLTRRAEVEEAYVRGGLATSSLALLEKQRLSPRSGRRTTYHYSNKPVPRKLF

--------------------------------------------------------------
>In-frame_ENST00000529637_ENST00000374332_TCGA-85-8070_USP48_chr1_22109316_-_MAN1C1_chr1_26110153_length(transcript)=2713nt_BP=168nt
GTCTGGCTCGGGAGGCGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCG
GCCCGAGGAGGTGTCGCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGTATCTCTATCT
TCTGTTCTCTGAAGATGACTTGCTCTCCCTGGAAGACTGGGTGTTCAACACCGAGGCCCACCCACTCCCGGTGAACCACTCAGACAGCTC
CGGCAGAGCCTGGGGCAGACACTGACCCCATCTCCTGCCGCCGCCCTGGGGCCGCCGCAGGGATGCCTTGCCTTTTCAGGATTTGAGACT
GTTCTCAAAGGGATTGGGAACGAAGGCCCCATCTCGGGCAGACCCCCAGCAGATGTGTCGGACAAGCAACTTCTTTTCCTCTGTGAGGAG
ACAAGACTTGGAGACTCAGCGATGTCAGGCCAGGGCCATGGCCACACTGGCCCACACATTCCTTTCTACAGAGAATTTCTATGAAGCCCA
CTCACTTGCCATTCCAGGGCCAAAGGACCGGAGGTTTGCATATCCGCCCCTTGTATTTGATTTGCTTCCTTTTGGTTTCTTGGTTTTTGT
TTTTGCTTGATTTTGTCTTTTCTCTACAGTTTAGTTTTGTCACAATTACACATATAGTTTTCAAAATCATGCACTTTCTAAAATGGTGTC
ATCCTGAAAAACAAAACCCAGTGTTTGCACACACACAAAATCTTGACCCCGTTATCTATATTTTAAATGCTTTTTGCCCAACACTGACCC
TATGTTCAACTTTGTGTCATTTACCTTATAATTTGAGGAGGGGTTTCCCTTTGGGCCTCAGTGTTACAAATTACTAGTGCTATTTTCATT
ATTATTGTAATGGAAAAATCTGTGGACTAGAATAAAAGAGTTTATTGAATAAGAAATATGATTGGGCTCATTGCACATCAGTGACTCCTA
GAAAAACCATTGCAATGTTACCATCAGAAATAATAATCAGCCAGCAGTTGATTTAAGGTATAATTTAGTAAACGATTCCAACTTCTATTA
CCTCCCCTGAAATCGGTCCTGATATATTCGAGAAGCATGAGGCCAGCCCTTCAGATGCAGTTGTTTATTTATACTCAGGTTTAGATTGGG
AAGAGGCCCAGGGAGGAGCAGCAACTTGCCTGAGGTCACACAGCCCAAAAAAGGCAAAGGAGAGTCTCGCCCCTGCCGTCTCCTGGCCAC
CCCAGTTGAGTGTCCGTCTGTTCCATCATTCAGCAGATGCTTGGTGAGTGCCTGCAACGGACCAGACACTGGGCTAGAGGCCAGGGACAC
CGCTGAGAGTGAGACAGTCATAAGCCCTGCAGTCAAGGGGTCAAGAGGGGAGAAAGCGATGGTAAGGGAAACTGACAAGTAAGTGAAGTG
ACTGCAGGTCATAGGAAATGCTACAAAGGAGATAGATAGACAGCTGAGGACCTACCCTACGGGGTCAGGGAGGGCCTCTCTGGGCAGGTG
ACCTTCAAGCCAAGACCCAGAAGATAAAAAGGAGCAGCCGAAAGACTATCTGGCAGAAGAATGAACTTCCCATAACCCAGCCCCCTTTCC
CACCCTCCCTGATGCCCTCCCTGGGAGGGGGCCTGAAACACTGGGGCTGTTGTGCAGAGCAAGGAGCTCAGGTCCTAACACTGAAGTGAC
AGCTCTTCCTCCCCTGACCCTTTTTTTTTTTTGAGACCCAGAGTCTCGTTCAGTCGCCCAGGCTGGAGTGCAGTGGTGCAATCTTGGCTC
ACTGCAACCTCCACCTCCTGGGTTCAAGCAGTTCTCCTGCCTCAGCTTCCCCAGTAGCAGGGTGCGTCACCACACCCGGCTAATTTTTTG
TATTTTTAGTAAAGACGAGGTTTTGCCATGTTGCCTAGGCTGGTCTTGAACTCCTGAGCTCAGGTGATCCGCCCACCTCAGCCTCCCAAA
GTGCGGGGATTACAGGCATGAGCCACCACACCCAGTCCTTTCCTGGCACATTTGCAGCTTGTCAACACAGCGGAAATCACGGGAGAATGT
TGAGCCCTTCCCTGGGCTCAGCTGCTTGCTCTGTTCATAAGCTTTAATAGCCCCCGGGGCTCTGGGCCAGGTGACCCGGCTTTAAATCCC
TGCTGTGTGAACTTAGGCAGGTACCTCCCCTCTCTGGGCTCTTCTTTTCCATCAAGCAGACAGAAAACCTCAACCCCACAAGGTTGCTGT
GAGAAGAAGTGGGAAGCTGCTGGTTCCCTGGGCACAGGAAGTGCTTGTTCCTTGTTCTGGAGACTCAAGACATTCCCAGAATCTTCTTAA
GCAGAGCTGCTGGGGAGTAGCCCCTGTAGCAAGTACCATGCTCTTGACAGGCAGCATGAGAGCGTGACTCCCATGACCCACCTGTGCTCA
AAAAAAAAAAAAAAAAAAAGCAAACCAGGAAAACTGACTACACAAACATTGTAGAAAGATTAGAAAATAGAAGCAGAAAGAAGACTCATT
GGCCATCCCACTCTCTGGGGTGAATACTGTTATATTTTCTTCTAGGCCTTTTTCTATGAATATATAGAATATAGATTTTGCCACCGTGGT
ATCCTACTATGCACACTGTTTTCTTATAATCTGCTTTTGCACTTAACTGTACATTGTGAACCTCTTTCCATGTCAACAAATACATGTTTA

>In-frame_ENST00000529637_ENST00000374332_TCGA-85-8070_USP48_chr1_22109316_-_MAN1C1_chr1_26110153_length(amino acids)=124AA_start in transcript=1451_stop in transcript=1077
MTCSHFTYLSVSLTIAFSPLDPLTAGLMTVSLSAVSLASSPVSGPLQALTKHLLNDGTDGHSTGVARRRQGRDSPLPFLGCVTSGKLLLL

--------------------------------------------------------------
>In-frame_ENST00000421625_ENST00000374332_TCGA-85-8070_USP48_chr1_22109316_-_MAN1C1_chr1_26110153_length(transcript)=3328nt_BP=783nt
GCTCGGGAAAGGGGTTCGGAACCGGTCTAGGCTCAAGTTAAATCTCCCTCTAAAGAGCCAACACTGGTTTCTTTGGCGACTCGGTTTCTA
CTCTAAACAGGTCCCGCTCCACAGTCTGGGCGGGCCTGTGTGTGCGTTGAGTAGCCTCTAGCGTGAAAACTTCATGGTTAAAAGGGAAGT
ACCGGAGGCAAGAAATAGCTTTCGAGGCACTGGTTTGTTAGAGTAGTGGTACGTAGTGCGCCGCCCTGAACGGGGGCTGAGACGCTGCTT
TTCCAGAAGTGCCAGTGAGGACGTGGCAAGACCGCCTCGGACGTACGCTTCCTCTACCTCAGCCCGTCGGGTTAGGGGCGCGGGAGGCGC
AGAGGCTGCTGGGAACGCGCATGCGCTCAGCGCGGCGGGGAGTCCACCTTTAACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCG
GCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGTGGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGA
GCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTGCAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGG
CGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTC
GCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGTATCTCTATCTTCTGTTCTCTGAAGA
TGACTTGCTCTCCCTGGAAGACTGGGTGTTCAACACCGAGGCCCACCCACTCCCGGTGAACCACTCAGACAGCTCCGGCAGAGCCTGGGG
CAGACACTGACCCCATCTCCTGCCGCCGCCCTGGGGCCGCCGCAGGGATGCCTTGCCTTTTCAGGATTTGAGACTGTTCTCAAAGGGATT
GGGAACGAAGGCCCCATCTCGGGCAGACCCCCAGCAGATGTGTCGGACAAGCAACTTCTTTTCCTCTGTGAGGAGACAAGACTTGGAGAC
TCAGCGATGTCAGGCCAGGGCCATGGCCACACTGGCCCACACATTCCTTTCTACAGAGAATTTCTATGAAGCCCACTCACTTGCCATTCC
AGGGCCAAAGGACCGGAGGTTTGCATATCCGCCCCTTGTATTTGATTTGCTTCCTTTTGGTTTCTTGGTTTTTGTTTTTGCTTGATTTTG
TCTTTTCTCTACAGTTTAGTTTTGTCACAATTACACATATAGTTTTCAAAATCATGCACTTTCTAAAATGGTGTCATCCTGAAAAACAAA
ACCCAGTGTTTGCACACACACAAAATCTTGACCCCGTTATCTATATTTTAAATGCTTTTTGCCCAACACTGACCCTATGTTCAACTTTGT
GTCATTTACCTTATAATTTGAGGAGGGGTTTCCCTTTGGGCCTCAGTGTTACAAATTACTAGTGCTATTTTCATTATTATTGTAATGGAA
AAATCTGTGGACTAGAATAAAAGAGTTTATTGAATAAGAAATATGATTGGGCTCATTGCACATCAGTGACTCCTAGAAAAACCATTGCAA
TGTTACCATCAGAAATAATAATCAGCCAGCAGTTGATTTAAGGTATAATTTAGTAAACGATTCCAACTTCTATTACCTCCCCTGAAATCG
GTCCTGATATATTCGAGAAGCATGAGGCCAGCCCTTCAGATGCAGTTGTTTATTTATACTCAGGTTTAGATTGGGAAGAGGCCCAGGGAG
GAGCAGCAACTTGCCTGAGGTCACACAGCCCAAAAAAGGCAAAGGAGAGTCTCGCCCCTGCCGTCTCCTGGCCACCCCAGTTGAGTGTCC
GTCTGTTCCATCATTCAGCAGATGCTTGGTGAGTGCCTGCAACGGACCAGACACTGGGCTAGAGGCCAGGGACACCGCTGAGAGTGAGAC
AGTCATAAGCCCTGCAGTCAAGGGGTCAAGAGGGGAGAAAGCGATGGTAAGGGAAACTGACAAGTAAGTGAAGTGACTGCAGGTCATAGG
AAATGCTACAAAGGAGATAGATAGACAGCTGAGGACCTACCCTACGGGGTCAGGGAGGGCCTCTCTGGGCAGGTGACCTTCAAGCCAAGA
CCCAGAAGATAAAAAGGAGCAGCCGAAAGACTATCTGGCAGAAGAATGAACTTCCCATAACCCAGCCCCCTTTCCCACCCTCCCTGATGC
CCTCCCTGGGAGGGGGCCTGAAACACTGGGGCTGTTGTGCAGAGCAAGGAGCTCAGGTCCTAACACTGAAGTGACAGCTCTTCCTCCCCT
GACCCTTTTTTTTTTTTGAGACCCAGAGTCTCGTTCAGTCGCCCAGGCTGGAGTGCAGTGGTGCAATCTTGGCTCACTGCAACCTCCACC
TCCTGGGTTCAAGCAGTTCTCCTGCCTCAGCTTCCCCAGTAGCAGGGTGCGTCACCACACCCGGCTAATTTTTTGTATTTTTAGTAAAGA
CGAGGTTTTGCCATGTTGCCTAGGCTGGTCTTGAACTCCTGAGCTCAGGTGATCCGCCCACCTCAGCCTCCCAAAGTGCGGGGATTACAG
GCATGAGCCACCACACCCAGTCCTTTCCTGGCACATTTGCAGCTTGTCAACACAGCGGAAATCACGGGAGAATGTTGAGCCCTTCCCTGG
GCTCAGCTGCTTGCTCTGTTCATAAGCTTTAATAGCCCCCGGGGCTCTGGGCCAGGTGACCCGGCTTTAAATCCCTGCTGTGTGAACTTA
GGCAGGTACCTCCCCTCTCTGGGCTCTTCTTTTCCATCAAGCAGACAGAAAACCTCAACCCCACAAGGTTGCTGTGAGAAGAAGTGGGAA
GCTGCTGGTTCCCTGGGCACAGGAAGTGCTTGTTCCTTGTTCTGGAGACTCAAGACATTCCCAGAATCTTCTTAAGCAGAGCTGCTGGGG
AGTAGCCCCTGTAGCAAGTACCATGCTCTTGACAGGCAGCATGAGAGCGTGACTCCCATGACCCACCTGTGCTCAAAAAAAAAAAAAAAA
AAAAGCAAACCAGGAAAACTGACTACACAAACATTGTAGAAAGATTAGAAAATAGAAGCAGAAAGAAGACTCATTGGCCATCCCACTCTC
TGGGGTGAATACTGTTATATTTTCTTCTAGGCCTTTTTCTATGAATATATAGAATATAGATTTTGCCACCGTGGTATCCTACTATGCACA

>In-frame_ENST00000421625_ENST00000374332_TCGA-85-8070_USP48_chr1_22109316_-_MAN1C1_chr1_26110153_length(amino acids)=194AA_start in transcript=731_stop in transcript=147
MCSCDTSSGRTVSAQRQAAFSSCSRGAMALAPGTPPEPDRRSRRRGLHRRPNGLRHLPARRTWRSFRQLASQSPVRATAAAPARARPARP
AAKRRRRHPTHPAPADVKGGLPAALSACAFPAASAPPAPLTRRAEVEEAYVRGGLATSSLALLEKQRLSPRSGRRTTYHYSNKPVPRKLF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USP48-MAN1C1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP48-MAN1C1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP48-MAN1C1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSP48C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneUSP48C0236733Amphetamine-Related Disorders1CTD_human
HgeneUSP48C0236804Amphetamine Addiction1CTD_human
HgeneUSP48C0236807Amphetamine Abuse1CTD_human