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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP49-DAAM2 (FusionGDB2 ID:96885)

Fusion Gene Summary for USP49-DAAM2

check button Fusion gene summary
Fusion gene informationFusion gene name: USP49-DAAM2
Fusion gene ID: 96885
HgeneTgene
Gene symbol

USP49

DAAM2

Gene ID

25862

23500

Gene nameubiquitin specific peptidase 49dishevelled associated activator of morphogenesis 2
Synonyms-dJ90A20A.1
Cytomap

6p21.1

6p21.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 49deubiquitinating enzyme 49ubiquitin specific protease 49ubiquitin thioesterase 49ubiquitin thiolesterase 49ubiquitin-specific-processing protease 49disheveled-associated activator of morphogenesis 2
Modification date2020031320200313
UniProtAcc.

Q86T65

Ensembl transtripts involved in fusion geneENST00000394253, ENST00000373010, 
ENST00000373006, ENST00000297229, 
ENST00000373009, 		ENST00000274867, 
ENST00000398904, ENST00000538976, 
ENST00000405961, ENST00000494405, 
Fusion gene scores* DoF score11 X 7 X 7=5396 X 7 X 5=210
# samples 107
** MAII scorelog2(10/539*10)=-2.43028527297778
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP49 [Title/Abstract] AND DAAM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP49(41859532)-DAAM2(39828704), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP49

GO:0016579

protein deubiquitination

14715245

HgeneUSP49

GO:0035616

histone H2B conserved C-terminal lysine deubiquitination

23824326


check buttonFusion gene breakpoints across USP49 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DAAM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3LU-01AUSP49chr6

41766613

-DAAM2chr6

39851738

+
ChimerDB4GBMTCGA-06-0129-01AUSP49chr6

41859532

-DAAM2chr6

39828704

+
ChimerDB4GBMTCGA-06-0129-01AUSP49chr6

41859532

-DAAM2chr6

39828704

+


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Fusion Gene ORF analysis for USP49-DAAM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000394253ENST00000274867USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-3CDSENST00000394253ENST00000398904USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-3CDSENST00000394253ENST00000538976USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-intronENST00000394253ENST00000405961USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-intronENST00000394253ENST00000494405USP49chr6

41766613

-DAAM2chr6

39851738

+
In-frameENST00000373010ENST00000274867USP49chr6

41766613

-DAAM2chr6

39851738

+
In-frameENST00000373010ENST00000398904USP49chr6

41766613

-DAAM2chr6

39851738

+
In-frameENST00000373010ENST00000538976USP49chr6

41766613

-DAAM2chr6

39851738

+
5CDS-intronENST00000373010ENST00000405961USP49chr6

41766613

-DAAM2chr6

39851738

+
5CDS-intronENST00000373010ENST00000494405USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-3CDSENST00000373006ENST00000274867USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-3CDSENST00000373006ENST00000398904USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-3CDSENST00000373006ENST00000538976USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-intronENST00000373006ENST00000405961USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-intronENST00000373006ENST00000494405USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-3CDSENST00000297229ENST00000274867USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-3CDSENST00000297229ENST00000398904USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-3CDSENST00000297229ENST00000538976USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-intronENST00000297229ENST00000405961USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-intronENST00000297229ENST00000494405USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-3CDSENST00000373009ENST00000274867USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-3CDSENST00000373009ENST00000398904USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-3CDSENST00000373009ENST00000538976USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-intronENST00000373009ENST00000405961USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-intronENST00000373009ENST00000494405USP49chr6

41766613

-DAAM2chr6

39851738

+
intron-3CDSENST00000394253ENST00000274867USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000394253ENST00000398904USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000394253ENST00000538976USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000394253ENST00000405961USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3UTRENST00000394253ENST00000494405USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000373010ENST00000274867USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000373010ENST00000398904USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000373010ENST00000538976USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000373010ENST00000405961USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3UTRENST00000373010ENST00000494405USP49chr6

41859532

-DAAM2chr6

39828704

+
5UTR-3CDSENST00000373006ENST00000274867USP49chr6

41859532

-DAAM2chr6

39828704

+
5UTR-3CDSENST00000373006ENST00000398904USP49chr6

41859532

-DAAM2chr6

39828704

+
5UTR-3CDSENST00000373006ENST00000538976USP49chr6

41859532

-DAAM2chr6

39828704

+
5UTR-3CDSENST00000373006ENST00000405961USP49chr6

41859532

-DAAM2chr6

39828704

+
5UTR-3UTRENST00000373006ENST00000494405USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000297229ENST00000274867USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000297229ENST00000398904USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000297229ENST00000538976USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000297229ENST00000405961USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3UTRENST00000297229ENST00000494405USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000373009ENST00000274867USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000373009ENST00000398904USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000373009ENST00000538976USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3CDSENST00000373009ENST00000405961USP49chr6

41859532

-DAAM2chr6

39828704

+
intron-3UTRENST00000373009ENST00000494405USP49chr6

41859532

-DAAM2chr6

39828704

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373010USP49chr641766613-ENST00000274867DAAM2chr639851738+6413222049535811028
ENST00000373010USP49chr641766613-ENST00000398904DAAM2chr639851738+6413222049535811028
ENST00000373010USP49chr641766613-ENST00000538976DAAM2chr639851738+6414222049535781027

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373010ENST00000274867USP49chr641766613-DAAM2chr639851738+0.0016964110.99830353
ENST00000373010ENST00000398904USP49chr641766613-DAAM2chr639851738+0.0016964110.99830353
ENST00000373010ENST00000538976USP49chr641766613-DAAM2chr639851738+0.0013753280.9986247

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Fusion Genomic Features for USP49-DAAM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USP49chr641766612-DAAM2chr639851737+0.0013681950.9986318
USP49chr641859531-DAAM2chr639828703+9.99E-050.9999001
USP49chr641766612-DAAM2chr639851737+0.0013681950.9986318
USP49chr641859531-DAAM2chr639828703+9.99E-050.9999001

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP49-DAAM2


check button Go to

FGviewer for the breakpoints of chr6:41766613-chr6:39851738

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DAAM2

Q86T65

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. {ECO:0000250|UniProtKB:Q80U19}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDAAM2chr6:41766613chr6:39851738ENST0000027486713251016_1048615.01069.0DomainDAD
TgeneDAAM2chr6:41766613chr6:39851738ENST0000039890413251016_1048615.01069.0DomainDAD
TgeneDAAM2chr6:41766613chr6:39851738ENST0000053897613251016_1048615.01068.0DomainDAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP49chr6:41766613chr6:39851738ENST00000297229-15253_6570641.0DomainNote=USP
HgeneUSP49chr6:41766613chr6:39851738ENST00000373006-17253_6570641.0DomainNote=USP
HgeneUSP49chr6:41766613chr6:39851738ENST00000373009-15253_6570.0689.0DomainNote=USP
HgeneUSP49chr6:41766613chr6:39851738ENST00000394253-17253_6570689.0DomainNote=USP
HgeneUSP49chr6:41766613chr6:39851738ENST00000297229-1524_850641.0Zinc fingerUBP-type
HgeneUSP49chr6:41766613chr6:39851738ENST00000373006-1724_850641.0Zinc fingerUBP-type
HgeneUSP49chr6:41766613chr6:39851738ENST00000373009-1524_850.0689.0Zinc fingerUBP-type
HgeneUSP49chr6:41766613chr6:39851738ENST00000394253-1724_850689.0Zinc fingerUBP-type
TgeneDAAM2chr6:41766613chr6:39851738ENST000002748671325434_516615.01069.0Coiled coilOntology_term=ECO:0000255
TgeneDAAM2chr6:41766613chr6:39851738ENST000003989041325434_516615.01069.0Coiled coilOntology_term=ECO:0000255
TgeneDAAM2chr6:41766613chr6:39851738ENST000005389761325434_516615.01068.0Coiled coilOntology_term=ECO:0000255
TgeneDAAM2chr6:41766613chr6:39851738ENST000002748671325518_604615.01069.0Compositional biasNote=Pro-rich
TgeneDAAM2chr6:41766613chr6:39851738ENST000003989041325518_604615.01069.0Compositional biasNote=Pro-rich
TgeneDAAM2chr6:41766613chr6:39851738ENST000005389761325518_604615.01068.0Compositional biasNote=Pro-rich
TgeneDAAM2chr6:41766613chr6:39851738ENST00000274867132540_416615.01069.0DomainGBD/FH3
TgeneDAAM2chr6:41766613chr6:39851738ENST000002748671325518_594615.01069.0DomainNote=FH1
TgeneDAAM2chr6:41766613chr6:39851738ENST000002748671325595_994615.01069.0DomainFH2
TgeneDAAM2chr6:41766613chr6:39851738ENST00000398904132540_416615.01069.0DomainGBD/FH3
TgeneDAAM2chr6:41766613chr6:39851738ENST000003989041325518_594615.01069.0DomainNote=FH1
TgeneDAAM2chr6:41766613chr6:39851738ENST000003989041325595_994615.01069.0DomainFH2
TgeneDAAM2chr6:41766613chr6:39851738ENST00000538976132540_416615.01068.0DomainGBD/FH3
TgeneDAAM2chr6:41766613chr6:39851738ENST000005389761325518_594615.01068.0DomainNote=FH1
TgeneDAAM2chr6:41766613chr6:39851738ENST000005389761325595_994615.01068.0DomainFH2


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Fusion Gene Sequence for USP49-DAAM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000373010_ENST00000274867_TCGA-DX-A3LU-01A_USP49_chr6_41766613_-_DAAM2_chr6_39851738_length(transcript)=6413nt_BP=2220nt
AGTGCTTCTTTTGCTGGGCAAATTGTGTGAAAGATGGGAGGGCAGCACTGTTGCTATTATGGATATTAACTTATCAGGACAATAAGGTCA
AAGTCCCTGTTAGAGCTAATTAGATTCTCCTTGACAAAAATTGGAGGTAGCAACAAAGAAAATCAATGCTGTGAAGTAGATTAGAAAACA
GGCTCGGAGAAGTTAAGGAAGGTCTTGTAATAAATGGACACCATGATGTTGACTGGTCTCTGTTACTCCACATCATGTGCTCTTCTTGCA
TGAGCCAGACAGCCCCTGAGAGTTCAGCATGTTTCAGTAACAGGATCTTGACAGCCAGCCATTCTGCAGCAAACCACCTACTCCAAGGGG
ACTGGACATGAGTGATGGGAGCCCATATTATGGGTAATAGAGAAGAGGAAACCTAACCAATGACTGTGGAATAATATGGAAGAAGATGGA
AAAAACTTGTTTAATGGGTTGAGAAAGTGGCGACTTCTATAAGACATGGATAGATGCAAACATGTAGGGCGGTTACGGCTCGCCCAGGAC
CACTCCATCCTGAACCCTCAGAAGTGGTGCTGCTTAGAGTGTGCCACCACCGAGTCCGTGTGGGCCTGCCTCAAGTGCTCCCACGTGGCC
TGCGGCCGCTATATTGAGGACCACGCCCTGAAACACTTTGAGGAGACGGGACACCCGCTAGCCATGGAAGTCCGGGATCTCTACGTGTTC
TGTTACCTGTGCAAGGACTACGTGCTCAATGATAACCCAGAGGGGGACCTGAAGCTGCTAAGAAGCTCCCTCCTGGCGGTCCGGGGCCAG
AAACAGGACACGCCGGTGAGACGTGGGCGGACGCTGCGGTCCATGGCTTCGGGTGAGGACGTGGTCCTGCCGCAGCGCGCTCCTCAGGGA
CAGCCGCAGATGCTCACGGCTCTGTGGTACCGGCGTCAGCGCCTGCTGGCCAGGACGCTGCGGCTGTGGTTCGAGAAGAGCTCCCGGGGC
CAGGCGAAGCTGGAGCAGCGGCGGCAGGAGGAGGCCCTGGAGCGCAAGAAGGAGGAGGCGCGGAGGCGGCGGCGCGAGGTGAAACGGCGG
CTGCTGGAGGAGCTGGCCAGCACCCCTCCGCGCAAGAGTGCACGGCTGCTCCTGCACACGCCCCGCGACGCGGGCCCGGCTGCCTCGCGC
CCCGCCGCCCTCCCTACCTCACGCAGAGTGCCCGCCGCCACACTCAAGCTGCGTCGCCAGCCGGCCATGGCCCCAGGCGTCACGGGCCTG
CGCAACCTGGGCAACACCTGCTACATGAACTCCATCCTCCAGGTGCTCAGCCACCTCCAGAAGTTCCGAGAATGTTTCCTCAACCTTGAC
CCTTCCAAAACGGAACATCTGTTTCCCAAAGCCACCAACGGGAAGACTCAGCTTTCTGGCAAGCCAACCAACAGCTCGGCCACGGAGCTG
TCCTTGAGAAATGACAGGGCCGAGGCATGCGAGCGGGAGGGCTTCTGCTGGAACGGCAGGGCCTCCATTAGTCGGAGTCTGGAGCTCATC
CAGAACAAGGAGCCGAGTTCAAAGCACATTTCCCTCTGCCGTGAACTGCACACCCTCTTCCGAGTCATGTGGTCCGGGAAGTGGGCCCTA
GTGTCGCCCTTCGCCATGCTCCACTCAGTGTGGAGCCTGATCCCTGCCTTCCGCGGCTACGACCAACAGGACGCGCAGGAATTTCTCTGC
GAGCTGCTGCACAAGGTGCAGCAGGAACTCGAGTCTGAGGGCACCACACGCCGGATCCTCATCCCCTTCTCCCAGAGGAAGCTCACCAAA
CAGGTCTTAAAGGTGGTGAATACCATATTTCATGGGCAGCTGCTCAGTCAGGTCACATGTATATCATGCAATTACAAATCCAATACCATT
GAGCCCTTTTGGGACCTATCCCTGGAATTCCCTGAACGCTATCACTGCATAGAAAAGGGGTTTGTCCCTTTGAATCAAACAGAGTGCTTG
CTCACTGAGATGCTGGCCAAATTCACAGAGACAGAGGCCCTGGAAGGGAGAATCTACGCTTGTGACCAGTGTAACAGCAAACGACGAAAA
TCCAATCCCAAACCCCTTGTTCTGAGTGAAGCTAGAAAGCAGTTAATGATCTACAGACTACCTCAGGTTCTCCGGCTGCACCTTAAAAGA
TTCAGGTGGTCTGGCCGTAATCATCGAGAGAAGATTGGGGTCCATGTCGTCTTTGACCAGGAGCGTGTCCCTGGCACCGTATGGAATGAG
ATTGATGACATGCAGGTATTTCGGATCCTGGACCTAGAGGATTTTGAAAAGATGTTTTCAGCCTACCAGAGGCACCAGAAAGAGCTGGGC
TCCACTGAAGACATCTACCTGGCTTCCCGCAAGGTCAAAGAGCTGTCGGTCATTGATGGCCGGAGGGCCCAAAACTGCATCATCCTTCTT
TCCAAGTTGAAGCTTTCTAACGAGGAGATCCGGCAGGCCATCTTGAAGATGGATGAGCAGGAGGACCTTGCTAAGGACATGCTGGAGCAG
CTCCTCAAGTTCATCCCAGAGAAGAGTGACATTGACCTCCTGGAGGAGCACAAGCATGAAATTGAGCGGATGGCCCGTGCTGACCGCTTC
CTCTATGAAATGAGCAGGATTGACCACTACCAGCAGCGACTGCAAGCCCTCTTCTTCAAGAAGAAATTCCAGGAGCGGCTGGCTGAGGCA
AAGCCCAAAGTGGAAGCCATCCTGTTGGCCTCCCGGGAGCTGGTCCGCAGCAAGCGTCTTAGACAGATGCTAGAGGTCATCCTAGCCATA
GGCAACTTCATGAACAAAGGGCAGCGTGGGGGCGCCTACGGGTTCCGGGTGGCCAGCCTCAACAAGATCGCTGACACCAAGTCCAGCATC
GACAGAAACATCTCTCTGCTCCATTACCTGATCATGATCCTGGAGAAGCATTTTCCTGATATTCTAAACATGCCTTCAGAGCTGCAACAT
CTTCCAGAAGCTGCCAAAGTCAACCTAGCAGAACTGGAGAAGGAGGTGGGCAACCTCAGGAGGGGCCTGAGAGCGGTGGAGGTGGAGCTG
GAGTATCAGAGGCGCCAGGTACGGGAGCCCAGTGACAAGTTTGTCCCTGTCATGAGCGACTTCATCACGGTGTCCAGCTTCAGCTTCTCC
GAGCTGGAGGACCAGCTAAATGAGGCCAGGGACAAGTTCGCCAAGGCCTTGATGCACTTCGGGGAGCATGACAGCAAGATGCAGCCAGAC
GAATTCTTTGGCATCTTTGATACCTTCTTGCAGGCCTTCTCAGAGGCCCGGCAGGATCTAGAGGCCATGAGGAGGAGGAAGGAGGAGGAG
GAGCGGCGGGCGCGCATGGAAGCCATGCTGAAGGAGCAGAGGGAACGTGAGCGGTGGCAGCGGCAGCGGAAGGTCCTGGCTGCAGGCAGC
TCGCTGGAGGAGGGAGGAGAGTTCGATGACCTGGTGTCGGCCCTGCGCTCTGGGGAGGTCTTCGACAAGGACTTATGCAAGCTCAAGCGC
AGCCGCAAGCGATCAGGGAGCCAGGCCCTGGAAGTTACCCGGGAGCGGGCAATAAACCGGCTAAATTATTGACCTGGGGAACTAGCCACA
CAGGAGGCCGGGAGACAGGGACTGGTGAGAATGGGGCTGAGTGGAGGAGGTGGTGATATTTAAACCATTTGGTGCTTGGTTTAGAGCCTT
GGGCTGGGTCCTGGGATGGGGGGCTGTGTGTGGCTGGACCAGGTGTCTCCCCACGCTTACCTTAAGGGGCTCCTCTTATCTCCCCTTCAC
ATGATTCCTTCTGTGCCCTGGCCCCAGGTATTATTCTGAGGCTGCCTTGGATGGCCTCAGGCCAGGTAACCCCAGGCTGAAGGGGCCCTG
CTCCCCATCCCCTACCATGGGCACCCATGTGCTGGCACAGAACAGTTCCAGATCTAGACTGGAGAGGTCCACAGCCTTGTCCAGAGTTCC
TGTGTAGCACGGGGAGCAATGATGGAGGGAGCCCCTGAGAGGGAATCTGGTGAGGGAATCCAGACTCCCTTCTCTCAAGGGGAGGCTCAA
CAGAACATTGACCTGGGGGCAAACTTTCCTCTTGAATGGGAACAGAGGAGGCATTATATATTCTAGTTAGATCAGCTCTGGTAGGTTCCA
GAGAACAGTCAATGTTGGAAGGATGATGCAGGGACCAAAGCCATCAGGACAGAGTAGCAGTGTCTGTTTCCCATGTCACAAGTCCTCTGG
CCTCTCCCTGCATGTCTTAAGTATCTTTCCCTTCCTTCTCTACCCTCACCTCCATCCTGTCTACTAATCCACAGTCCTAGAAGACTCACC
TTGGGTTTCCACAGCTATGGCTCACTACCAGGTGCTTGATGAATCTGGCGAGGGGCTCAAGACAGACCTCATGCATCACCACACCTCATG
CCTTTTGGGCATCTCCCATGTCCCCATCTCCTGGACACCTGGCCATTGTTGTGAAGCCAGACAGTGACCTCAAATGTTGCCTTGGAGTCC
CCTACAGCCCCTCAGCAGAGGGCAGCACTTGAATGCTTAGCTCCATCCCATAGTTCTCTACTTCATATAAATTGCTCAGGCCCTCCCACC
CCTTCTCTAACACTAGCTTCAAGGCAGAAGCCACAGCAGCCTCTGTCCAGCCTGCAGGTGGCCACTTGGAACCATGTGTCCACTGGCGTT
GGGGAGTTGGTTCCTGAGAGGTCTGAGGGCCAGAGCTGCCCTCTACATTAACATGCTGTCTCTAAGGGTGGCCCCTCCTCTCAGGCGTTC
AGATGGTGCGAACAGCAGAGCAGGCAAGGGAAACTGGGGAGATGGGGATGGAGGAGGAAGGCTGATATCCTCTGGGGAGCACATCACCTG
AAGGTGCCAAGGAGGAAGGCTGAGAGGGGGGCCACCCCATTTCTGGTACCCAATTTGGTTCTTCAGCCCAACTTGCAAGGGGTTCCTTCT
GGTCCTCCCATCCACTGCCACCTTCCATTTTGTCCATCTCATGCTGGCCTTGGTGGATGGGATGGCTGTATCTAGACAAAATTTTTCTAA
AACTCCATCAAGGCTCTTATTCAATACCACGTTCCGAGTTGGCCTTTCATCTTCTTTGAGACTGGCCCTGCCTAACCTCTACCATCAATG
AGCTCTTGGCCCTTCTGCCCTTCCCTGTGTTTCTCACTTTCCAACCTAATCCCTGGCTCAGGGTTATTGCCAGTGGAGACTGGTGAGCTG
GGCCTACTCTCAGCTGCCTATCTTCTGCCTTTCACTTGCATCCAACTCCTGGGGCTGGGACCGTAGTAGCTGCGGGGGGGAAGAAACACA
GGGTCGGTGAGCCCAGCATGTGCGTTGGTTTGAGGGGGCGGGCGGTGTGTGTGTGTTCTGGTGGGAGGGATCTGAGCAAGTGCAAGCCTG
GCTGACACAGGTGTGAAGAGGCCATCCTGGAACCCAGGTGAGGGCAAGATGAAGGCTTCCAGGCAGAACAGCTGCAGAGAGTTTGGCTAT
ATGCATCTGCAGCCCCAAGAGCTCCCACTGCAAGACAAGTGTTGGGGAAGATGGGAGGTTGTGGGTGAGGCCTCTAAAGGTCCTCTCCCA
AACTGACCAGGCTGATGTCAACCTAACCCCCTCAGGGGCAGGGAACAGGGGAGGGCTCCACAAGCGTGTCTGGCATTCCCACCCACCATG
GAAGACTGGATACGCACCTGGAAACAAAAGGACTATGGAAGCTGTTCAAGATACATTTGATCTTCAGAAAAGCAGAATTTGGTTCAACTG
TTGACAGAGGACACAAATACGTTGTTCCAGAGCTCAGCCTTCTCACTCTAAAAGAAAGATATTTTTCTATTTATTTTCTACATCTGGCCA
GTGGCTCTGGTGCTAGATGCCACTGTAGCCAGATCTCCAACAGTGCCTTGGACCATGGACTCATACTCAACTGAGTAAGAAGGGGCTGGT
GCCCAGTCGGGGTGGCTGAGCTGGTCCTTAATAGGTTGTTTCTTGGTCTTGCTTTCTTCATGCCCTCCCCACTGCTCCTGCCACCTTTAG
ATAAGTTTCTCTAGCTAATTTTGTGGCCAATGTAAAATTCGTCATCAACCTAACAAACACAACCTTCTCAGCAGCATTTCTCCCCTGTGA
TGGAAATAAAGTGTTTAGGGCAGTGGGAGGAGAAAATTCTCCAGGTGAATGGGGAAGGGTCTGTTCCAGCCTCTCCCTACTCCCATCCCA
TTTCCACCAACTGGGGAACTGTGACTATCTATCTCCCCCGACTTCTACCAGGGATGCCTTCACGCCAAGGCTGTTCTCACCAGCTGCCTC
AGATGACAAATGAGGCTAATGGACATAATCTACAGTGTCCTTTTTCACTTGCACCTTTTTTATAAGAATATATTGTAATACTAAAAAATA

>In-frame_ENST00000373010_ENST00000274867_TCGA-DX-A3LU-01A_USP49_chr6_41766613_-_DAAM2_chr6_39851738_length(amino acids)=1028AA_start in transcript=495_stop in transcript=3581
MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVLNDNPEG
DLKLLRSSLLAVRGQKQDTPVRRGRTLRSMASGEDVVLPQRAPQGQPQMLTALWYRRQRLLARTLRLWFEKSSRGQAKLEQRRQEEALER
KKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATLKLRRQPAMAPGVTGLRNLGNTCYMNSILQV
LSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRE
LHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLL
SQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEARKQL
MIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKEL
SVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQ
ALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILE
KHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAK
ALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSAL

--------------------------------------------------------------
>In-frame_ENST00000373010_ENST00000398904_TCGA-DX-A3LU-01A_USP49_chr6_41766613_-_DAAM2_chr6_39851738_length(transcript)=6413nt_BP=2220nt
AGTGCTTCTTTTGCTGGGCAAATTGTGTGAAAGATGGGAGGGCAGCACTGTTGCTATTATGGATATTAACTTATCAGGACAATAAGGTCA
AAGTCCCTGTTAGAGCTAATTAGATTCTCCTTGACAAAAATTGGAGGTAGCAACAAAGAAAATCAATGCTGTGAAGTAGATTAGAAAACA
GGCTCGGAGAAGTTAAGGAAGGTCTTGTAATAAATGGACACCATGATGTTGACTGGTCTCTGTTACTCCACATCATGTGCTCTTCTTGCA
TGAGCCAGACAGCCCCTGAGAGTTCAGCATGTTTCAGTAACAGGATCTTGACAGCCAGCCATTCTGCAGCAAACCACCTACTCCAAGGGG
ACTGGACATGAGTGATGGGAGCCCATATTATGGGTAATAGAGAAGAGGAAACCTAACCAATGACTGTGGAATAATATGGAAGAAGATGGA
AAAAACTTGTTTAATGGGTTGAGAAAGTGGCGACTTCTATAAGACATGGATAGATGCAAACATGTAGGGCGGTTACGGCTCGCCCAGGAC
CACTCCATCCTGAACCCTCAGAAGTGGTGCTGCTTAGAGTGTGCCACCACCGAGTCCGTGTGGGCCTGCCTCAAGTGCTCCCACGTGGCC
TGCGGCCGCTATATTGAGGACCACGCCCTGAAACACTTTGAGGAGACGGGACACCCGCTAGCCATGGAAGTCCGGGATCTCTACGTGTTC
TGTTACCTGTGCAAGGACTACGTGCTCAATGATAACCCAGAGGGGGACCTGAAGCTGCTAAGAAGCTCCCTCCTGGCGGTCCGGGGCCAG
AAACAGGACACGCCGGTGAGACGTGGGCGGACGCTGCGGTCCATGGCTTCGGGTGAGGACGTGGTCCTGCCGCAGCGCGCTCCTCAGGGA
CAGCCGCAGATGCTCACGGCTCTGTGGTACCGGCGTCAGCGCCTGCTGGCCAGGACGCTGCGGCTGTGGTTCGAGAAGAGCTCCCGGGGC
CAGGCGAAGCTGGAGCAGCGGCGGCAGGAGGAGGCCCTGGAGCGCAAGAAGGAGGAGGCGCGGAGGCGGCGGCGCGAGGTGAAACGGCGG
CTGCTGGAGGAGCTGGCCAGCACCCCTCCGCGCAAGAGTGCACGGCTGCTCCTGCACACGCCCCGCGACGCGGGCCCGGCTGCCTCGCGC
CCCGCCGCCCTCCCTACCTCACGCAGAGTGCCCGCCGCCACACTCAAGCTGCGTCGCCAGCCGGCCATGGCCCCAGGCGTCACGGGCCTG
CGCAACCTGGGCAACACCTGCTACATGAACTCCATCCTCCAGGTGCTCAGCCACCTCCAGAAGTTCCGAGAATGTTTCCTCAACCTTGAC
CCTTCCAAAACGGAACATCTGTTTCCCAAAGCCACCAACGGGAAGACTCAGCTTTCTGGCAAGCCAACCAACAGCTCGGCCACGGAGCTG
TCCTTGAGAAATGACAGGGCCGAGGCATGCGAGCGGGAGGGCTTCTGCTGGAACGGCAGGGCCTCCATTAGTCGGAGTCTGGAGCTCATC
CAGAACAAGGAGCCGAGTTCAAAGCACATTTCCCTCTGCCGTGAACTGCACACCCTCTTCCGAGTCATGTGGTCCGGGAAGTGGGCCCTA
GTGTCGCCCTTCGCCATGCTCCACTCAGTGTGGAGCCTGATCCCTGCCTTCCGCGGCTACGACCAACAGGACGCGCAGGAATTTCTCTGC
GAGCTGCTGCACAAGGTGCAGCAGGAACTCGAGTCTGAGGGCACCACACGCCGGATCCTCATCCCCTTCTCCCAGAGGAAGCTCACCAAA
CAGGTCTTAAAGGTGGTGAATACCATATTTCATGGGCAGCTGCTCAGTCAGGTCACATGTATATCATGCAATTACAAATCCAATACCATT
GAGCCCTTTTGGGACCTATCCCTGGAATTCCCTGAACGCTATCACTGCATAGAAAAGGGGTTTGTCCCTTTGAATCAAACAGAGTGCTTG
CTCACTGAGATGCTGGCCAAATTCACAGAGACAGAGGCCCTGGAAGGGAGAATCTACGCTTGTGACCAGTGTAACAGCAAACGACGAAAA
TCCAATCCCAAACCCCTTGTTCTGAGTGAAGCTAGAAAGCAGTTAATGATCTACAGACTACCTCAGGTTCTCCGGCTGCACCTTAAAAGA
TTCAGGTGGTCTGGCCGTAATCATCGAGAGAAGATTGGGGTCCATGTCGTCTTTGACCAGGAGCGTGTCCCTGGCACCGTATGGAATGAG
ATTGATGACATGCAGGTATTTCGGATCCTGGACCTAGAGGATTTTGAAAAGATGTTTTCAGCCTACCAGAGGCACCAGAAAGAGCTGGGC
TCCACTGAAGACATCTACCTGGCTTCCCGCAAGGTCAAAGAGCTGTCGGTCATTGATGGCCGGAGGGCCCAAAACTGCATCATCCTTCTT
TCCAAGTTGAAGCTTTCTAACGAGGAGATCCGGCAGGCCATCTTGAAGATGGATGAGCAGGAGGACCTTGCTAAGGACATGCTGGAGCAG
CTCCTCAAGTTCATCCCAGAGAAGAGTGACATTGACCTCCTGGAGGAGCACAAGCATGAAATTGAGCGGATGGCCCGTGCTGACCGCTTC
CTCTATGAAATGAGCAGGATTGACCACTACCAGCAGCGACTGCAAGCCCTCTTCTTCAAGAAGAAATTCCAGGAGCGGCTGGCTGAGGCA
AAGCCCAAAGTGGAAGCCATCCTGTTGGCCTCCCGGGAGCTGGTCCGCAGCAAGCGTCTTAGACAGATGCTAGAGGTCATCCTAGCCATA
GGCAACTTCATGAACAAAGGGCAGCGTGGGGGCGCCTACGGGTTCCGGGTGGCCAGCCTCAACAAGATCGCTGACACCAAGTCCAGCATC
GACAGAAACATCTCTCTGCTCCATTACCTGATCATGATCCTGGAGAAGCATTTTCCTGATATTCTAAACATGCCTTCAGAGCTGCAACAT
CTTCCAGAAGCTGCCAAAGTCAACCTAGCAGAACTGGAGAAGGAGGTGGGCAACCTCAGGAGGGGCCTGAGAGCGGTGGAGGTGGAGCTG
GAGTATCAGAGGCGCCAGGTACGGGAGCCCAGTGACAAGTTTGTCCCTGTCATGAGCGACTTCATCACGGTGTCCAGCTTCAGCTTCTCC
GAGCTGGAGGACCAGCTAAATGAGGCCAGGGACAAGTTCGCCAAGGCCTTGATGCACTTCGGGGAGCATGACAGCAAGATGCAGCCAGAC
GAATTCTTTGGCATCTTTGATACCTTCTTGCAGGCCTTCTCAGAGGCCCGGCAGGATCTAGAGGCCATGAGGAGGAGGAAGGAGGAGGAG
GAGCGGCGGGCGCGCATGGAAGCCATGCTGAAGGAGCAGAGGGAACGTGAGCGGTGGCAGCGGCAGCGGAAGGTCCTGGCTGCAGGCAGC
TCGCTGGAGGAGGGAGGAGAGTTCGATGACCTGGTGTCGGCCCTGCGCTCTGGGGAGGTCTTCGACAAGGACTTATGCAAGCTCAAGCGC
AGCCGCAAGCGATCAGGGAGCCAGGCCCTGGAAGTTACCCGGGAGCGGGCAATAAACCGGCTAAATTATTGACCTGGGGAACTAGCCACA
CAGGAGGCCGGGAGACAGGGACTGGTGAGAATGGGGCTGAGTGGAGGAGGTGGTGATATTTAAACCATTTGGTGCTTGGTTTAGAGCCTT
GGGCTGGGTCCTGGGATGGGGGGCTGTGTGTGGCTGGACCAGGTGTCTCCCCACGCTTACCTTAAGGGGCTCCTCTTATCTCCCCTTCAC
ATGATTCCTTCTGTGCCCTGGCCCCAGGTATTATTCTGAGGCTGCCTTGGATGGCCTCAGGCCAGGTAACCCCAGGCTGAAGGGGCCCTG
CTCCCCATCCCCTACCATGGGCACCCATGTGCTGGCACAGAACAGTTCCAGATCTAGACTGGAGAGGTCCACAGCCTTGTCCAGAGTTCC
TGTGTAGCACGGGGAGCAATGATGGAGGGAGCCCCTGAGAGGGAATCTGGTGAGGGAATCCAGACTCCCTTCTCTCAAGGGGAGGCTCAA
CAGAACATTGACCTGGGGGCAAACTTTCCTCTTGAATGGGAACAGAGGAGGCATTATATATTCTAGTTAGATCAGCTCTGGTAGGTTCCA
GAGAACAGTCAATGTTGGAAGGATGATGCAGGGACCAAAGCCATCAGGACAGAGTAGCAGTGTCTGTTTCCCATGTCACAAGTCCTCTGG
CCTCTCCCTGCATGTCTTAAGTATCTTTCCCTTCCTTCTCTACCCTCACCTCCATCCTGTCTACTAATCCACAGTCCTAGAAGACTCACC
TTGGGTTTCCACAGCTATGGCTCACTACCAGGTGCTTGATGAATCTGGCGAGGGGCTCAAGACAGACCTCATGCATCACCACACCTCATG
CCTTTTGGGCATCTCCCATGTCCCCATCTCCTGGACACCTGGCCATTGTTGTGAAGCCAGACAGTGACCTCAAATGTTGCCTTGGAGTCC
CCTACAGCCCCTCAGCAGAGGGCAGCACTTGAATGCTTAGCTCCATCCCATAGTTCTCTACTTCATATAAATTGCTCAGGCCCTCCCACC
CCTTCTCTAACACTAGCTTCAAGGCAGAAGCCACAGCAGCCTCTGTCCAGCCTGCAGGTGGCCACTTGGAACCATGTGTCCACTGGCGTT
GGGGAGTTGGTTCCTGAGAGGTCTGAGGGCCAGAGCTGCCCTCTACATTAACATGCTGTCTCTAAGGGTGGCCCCTCCTCTCAGGCGTTC
AGATGGTGCGAACAGCAGAGCAGGCAAGGGAAACTGGGGAGATGGGGATGGAGGAGGAAGGCTGATATCCTCTGGGGAGCACATCACCTG
AAGGTGCCAAGGAGGAAGGCTGAGAGGGGGGCCACCCCATTTCTGGTACCCAATTTGGTTCTTCAGCCCAACTTGCAAGGGGTTCCTTCT
GGTCCTCCCATCCACTGCCACCTTCCATTTTGTCCATCTCATGCTGGCCTTGGTGGATGGGATGGCTGTATCTAGACAAAATTTTTCTAA
AACTCCATCAAGGCTCTTATTCAATACCACGTTCCGAGTTGGCCTTTCATCTTCTTTGAGACTGGCCCTGCCTAACCTCTACCATCAATG
AGCTCTTGGCCCTTCTGCCCTTCCCTGTGTTTCTCACTTTCCAACCTAATCCCTGGCTCAGGGTTATTGCCAGTGGAGACTGGTGAGCTG
GGCCTACTCTCAGCTGCCTATCTTCTGCCTTTCACTTGCATCCAACTCCTGGGGCTGGGACCGTAGTAGCTGCGGGGGGGAAGAAACACA
GGGTCGGTGAGCCCAGCATGTGCGTTGGTTTGAGGGGGCGGGCGGTGTGTGTGTGTTCTGGTGGGAGGGATCTGAGCAAGTGCAAGCCTG
GCTGACACAGGTGTGAAGAGGCCATCCTGGAACCCAGGTGAGGGCAAGATGAAGGCTTCCAGGCAGAACAGCTGCAGAGAGTTTGGCTAT
ATGCATCTGCAGCCCCAAGAGCTCCCACTGCAAGACAAGTGTTGGGGAAGATGGGAGGTTGTGGGTGAGGCCTCTAAAGGTCCTCTCCCA
AACTGACCAGGCTGATGTCAACCTAACCCCCTCAGGGGCAGGGAACAGGGGAGGGCTCCACAAGCGTGTCTGGCATTCCCACCCACCATG
GAAGACTGGATACGCACCTGGAAACAAAAGGACTATGGAAGCTGTTCAAGATACATTTGATCTTCAGAAAAGCAGAATTTGGTTCAACTG
TTGACAGAGGACACAAATACGTTGTTCCAGAGCTCAGCCTTCTCACTCTAAAAGAAAGATATTTTTCTATTTATTTTCTACATCTGGCCA
GTGGCTCTGGTGCTAGATGCCACTGTAGCCAGATCTCCAACAGTGCCTTGGACCATGGACTCATACTCAACTGAGTAAGAAGGGGCTGGT
GCCCAGTCGGGGTGGCTGAGCTGGTCCTTAATAGGTTGTTTCTTGGTCTTGCTTTCTTCATGCCCTCCCCACTGCTCCTGCCACCTTTAG
ATAAGTTTCTCTAGCTAATTTTGTGGCCAATGTAAAATTCGTCATCAACCTAACAAACACAACCTTCTCAGCAGCATTTCTCCCCTGTGA
TGGAAATAAAGTGTTTAGGGCAGTGGGAGGAGAAAATTCTCCAGGTGAATGGGGAAGGGTCTGTTCCAGCCTCTCCCTACTCCCATCCCA
TTTCCACCAACTGGGGAACTGTGACTATCTATCTCCCCCGACTTCTACCAGGGATGCCTTCACGCCAAGGCTGTTCTCACCAGCTGCCTC
AGATGACAAATGAGGCTAATGGACATAATCTACAGTGTCCTTTTTCACTTGCACCTTTTTTATAAGAATATATTGTAATACTAAAAAATA

>In-frame_ENST00000373010_ENST00000398904_TCGA-DX-A3LU-01A_USP49_chr6_41766613_-_DAAM2_chr6_39851738_length(amino acids)=1028AA_start in transcript=495_stop in transcript=3581
MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVLNDNPEG
DLKLLRSSLLAVRGQKQDTPVRRGRTLRSMASGEDVVLPQRAPQGQPQMLTALWYRRQRLLARTLRLWFEKSSRGQAKLEQRRQEEALER
KKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATLKLRRQPAMAPGVTGLRNLGNTCYMNSILQV
LSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRE
LHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLL
SQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEARKQL
MIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKEL
SVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQ
ALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILE
KHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAK
ALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSAL

--------------------------------------------------------------
>In-frame_ENST00000373010_ENST00000538976_TCGA-DX-A3LU-01A_USP49_chr6_41766613_-_DAAM2_chr6_39851738_length(transcript)=6414nt_BP=2220nt
AGTGCTTCTTTTGCTGGGCAAATTGTGTGAAAGATGGGAGGGCAGCACTGTTGCTATTATGGATATTAACTTATCAGGACAATAAGGTCA
AAGTCCCTGTTAGAGCTAATTAGATTCTCCTTGACAAAAATTGGAGGTAGCAACAAAGAAAATCAATGCTGTGAAGTAGATTAGAAAACA
GGCTCGGAGAAGTTAAGGAAGGTCTTGTAATAAATGGACACCATGATGTTGACTGGTCTCTGTTACTCCACATCATGTGCTCTTCTTGCA
TGAGCCAGACAGCCCCTGAGAGTTCAGCATGTTTCAGTAACAGGATCTTGACAGCCAGCCATTCTGCAGCAAACCACCTACTCCAAGGGG
ACTGGACATGAGTGATGGGAGCCCATATTATGGGTAATAGAGAAGAGGAAACCTAACCAATGACTGTGGAATAATATGGAAGAAGATGGA
AAAAACTTGTTTAATGGGTTGAGAAAGTGGCGACTTCTATAAGACATGGATAGATGCAAACATGTAGGGCGGTTACGGCTCGCCCAGGAC
CACTCCATCCTGAACCCTCAGAAGTGGTGCTGCTTAGAGTGTGCCACCACCGAGTCCGTGTGGGCCTGCCTCAAGTGCTCCCACGTGGCC
TGCGGCCGCTATATTGAGGACCACGCCCTGAAACACTTTGAGGAGACGGGACACCCGCTAGCCATGGAAGTCCGGGATCTCTACGTGTTC
TGTTACCTGTGCAAGGACTACGTGCTCAATGATAACCCAGAGGGGGACCTGAAGCTGCTAAGAAGCTCCCTCCTGGCGGTCCGGGGCCAG
AAACAGGACACGCCGGTGAGACGTGGGCGGACGCTGCGGTCCATGGCTTCGGGTGAGGACGTGGTCCTGCCGCAGCGCGCTCCTCAGGGA
CAGCCGCAGATGCTCACGGCTCTGTGGTACCGGCGTCAGCGCCTGCTGGCCAGGACGCTGCGGCTGTGGTTCGAGAAGAGCTCCCGGGGC
CAGGCGAAGCTGGAGCAGCGGCGGCAGGAGGAGGCCCTGGAGCGCAAGAAGGAGGAGGCGCGGAGGCGGCGGCGCGAGGTGAAACGGCGG
CTGCTGGAGGAGCTGGCCAGCACCCCTCCGCGCAAGAGTGCACGGCTGCTCCTGCACACGCCCCGCGACGCGGGCCCGGCTGCCTCGCGC
CCCGCCGCCCTCCCTACCTCACGCAGAGTGCCCGCCGCCACACTCAAGCTGCGTCGCCAGCCGGCCATGGCCCCAGGCGTCACGGGCCTG
CGCAACCTGGGCAACACCTGCTACATGAACTCCATCCTCCAGGTGCTCAGCCACCTCCAGAAGTTCCGAGAATGTTTCCTCAACCTTGAC
CCTTCCAAAACGGAACATCTGTTTCCCAAAGCCACCAACGGGAAGACTCAGCTTTCTGGCAAGCCAACCAACAGCTCGGCCACGGAGCTG
TCCTTGAGAAATGACAGGGCCGAGGCATGCGAGCGGGAGGGCTTCTGCTGGAACGGCAGGGCCTCCATTAGTCGGAGTCTGGAGCTCATC
CAGAACAAGGAGCCGAGTTCAAAGCACATTTCCCTCTGCCGTGAACTGCACACCCTCTTCCGAGTCATGTGGTCCGGGAAGTGGGCCCTA
GTGTCGCCCTTCGCCATGCTCCACTCAGTGTGGAGCCTGATCCCTGCCTTCCGCGGCTACGACCAACAGGACGCGCAGGAATTTCTCTGC
GAGCTGCTGCACAAGGTGCAGCAGGAACTCGAGTCTGAGGGCACCACACGCCGGATCCTCATCCCCTTCTCCCAGAGGAAGCTCACCAAA
CAGGTCTTAAAGGTGGTGAATACCATATTTCATGGGCAGCTGCTCAGTCAGGTCACATGTATATCATGCAATTACAAATCCAATACCATT
GAGCCCTTTTGGGACCTATCCCTGGAATTCCCTGAACGCTATCACTGCATAGAAAAGGGGTTTGTCCCTTTGAATCAAACAGAGTGCTTG
CTCACTGAGATGCTGGCCAAATTCACAGAGACAGAGGCCCTGGAAGGGAGAATCTACGCTTGTGACCAGTGTAACAGCAAACGACGAAAA
TCCAATCCCAAACCCCTTGTTCTGAGTGAAGCTAGAAAGCAGTTAATGATCTACAGACTACCTCAGGTTCTCCGGCTGCACCTTAAAAGA
TTCAGGTGGTCTGGCCGTAATCATCGAGAGAAGATTGGGGTCCATGTCGTCTTTGACCAGGAGCGTGTCCCTGGCACCGTATGGAATGAG
ATTGATGACATGCAGGTATTTCGGATCCTGGACCTAGAGGATTTTGAAAAGATGTTTTCAGCCTACCAGAGGCACCAGAAAGAGCTGGGC
TCCACTGAAGACATCTACCTGGCTTCCCGCAAGGTCAAAGAGCTGTCGGTCATTGATGGCCGGAGGGCCCAAAACTGCATCATCCTTCTT
TCCAAGTTGAAGCTTTCTAACGAGGAGATCCGGCAGGCCATCTTGAAGATGGATGAGCAGGAGGACCTTGCTAAGGACATGCTGGAGCAG
CTCCTCAAGTTCATCCCAGAGAAGAGTGACATTGACCTCCTGGAGGAGCACAAGCATGAAATTGAGCGGATGGCCCGTGCTGACCGCTTC
CTCTATGAAATGAGCAGGATTGACCACTACCAGCAGCGACTGCAAGCCCTCTTCTTCAAGAAGAAATTCCAGGAGCGGCTGGCTGAGGCA
AAGCCCAAAGTGGAAGCCATCCTGTTGGCCTCCCGGGAGCTGGTCCGCAGCAAGCGTCTTAGACAGATGCTAGAGGTCATCCTAGCCATA
GGCAACTTCATGAACAAAGGGCAGCGTGGGGGCGCCTACGGGTTCCGGGTGGCCAGCCTCAACAAGATCGCTGACACCAAGTCCAGCATC
GACAGAAACATCTCTCTGCTCCATTACCTGATCATGATCCTGGAGAAGCATTTTCCTGATATTCTAAACATGCCTTCAGAGCTGCAACAT
CTTCCAGAAGCTGCCAAAGTCAACCTAGCAGAACTGGAGAAGGAGGTGGGCAACCTCAGGAGGGGCCTGAGAGCGGTGGAGGTGCTGGAG
TATCAGAGGCGCCAGGTACGGGAGCCCAGTGACAAGTTTGTCCCTGTCATGAGCGACTTCATCACGGTGTCCAGCTTCAGCTTCTCCGAG
CTGGAGGACCAGCTAAATGAGGCCAGGGACAAGTTCGCCAAGGCCTTGATGCACTTCGGGGAGCATGACAGCAAGATGCAGCCAGACGAA
TTCTTTGGCATCTTTGATACCTTCTTGCAGGCCTTCTCAGAGGCCCGGCAGGATCTAGAGGCCATGAGGAGGAGGAAGGAGGAGGAGGAG
CGGCGGGCGCGCATGGAAGCCATGCTGAAGGAGCAGAGGGAACGTGAGCGGTGGCAGCGGCAGCGGAAGGTCCTGGCTGCAGGCAGCTCG
CTGGAGGAGGGAGGAGAGTTCGATGACCTGGTGTCGGCCCTGCGCTCTGGGGAGGTCTTCGACAAGGACTTATGCAAGCTCAAGCGCAGC
CGCAAGCGATCAGGGAGCCAGGCCCTGGAAGTTACCCGGGAGCGGGCAATAAACCGGCTAAATTATTGACCTGGGGAACTAGCCACACAG
GAGGCCGGGAGACAGGGACTGGTGAGAATGGGGCTGAGTGGAGGAGGTGGTGATATTTAAACCATTTGGTGCTTGGTTTAGAGCCTTGGG
CTGGGTCCTGGGATGGGGGGCTGTGTGTGGCTGGACCAGGTGTCTCCCCACGCTTACCTTAAGGGGCTCCTCTTATCTCCCCTTCACATG
ATTCCTTCTGTGCCCTGGCCCCAGGTATTATTCTGAGGCTGCCTTGGATGGCCTCAGGCCAGGTAACCCCAGGCTGAAGGGGCCCTGCTC
CCCATCCCCTACCATGGGCACCCATGTGCTGGCACAGAACAGTTCCAGATCTAGACTGGAGAGGTCCACAGCCTTGTCCAGAGTTCCTGT
GTAGCACGGGGAGCAATGATGGAGGGAGCCCCTGAGAGGGAATCTGGTGAGGGAATCCAGACTCCCTTCTCTCAAGGGGAGGCTCAACAG
AACATTGACCTGGGGGCAAACTTTCCTCTTGAATGGGAACAGAGGAGGCATTATATATTCTAGTTAGATCAGCTCTGGTAGGTTCCAGAG
AACAGTCAATGTTGGAAGGATGATGCAGGGACCAAAGCCATCAGGACAGAGTAGCAGTGTCTGTTTCCCATGTCACAAGTCCTCTGGCCT
CTCCCTGCATGTCTTAAGTATCTTTCCCTTCCTTCTCTACCCTCACCTCCATCCTGTCTACTAATCCACAGTCCTAGAAGACTCACCTTG
GGTTTCCACAGCTATGGCTCACTACCAGGTGCTTGATGAATCTGGCGAGGGGCTCAAGACAGACCTCATGCATCACCACACCTCATGCCT
TTTGGGCATCTCCCATGTCCCCATCTCCTGGACACCTGGCCATTGTTGTGAAGCCAGACAGTGACCTCAAATGTTGCCTTGGAGTCCCCT
ACAGCCCCTCAGCAGAGGGCAGCACTTGAATGCTTAGCTCCATCCCATAGTTCTCTACTTCATATAAATTGCTCAGGCCCTCCCACCCCT
TCTCTAACACTAGCTTCAAGGCAGAAGCCACAGCAGCCTCTGTCCAGCCTGCAGGTGGCCACTTGGAACCATGTGTCCACTGGCGTTGGG
GAGTTGGTTCCTGAGAGGTCTGAGGGCCAGAGCTGCCCTCTACATTAACATGCTGTCTCTAAGGGTGGCCCCTCCTCTCAGGCGTTCAGA
TGGTGCGAACAGCAGAGCAGGCAAGGGAAACTGGGGAGATGGGGATGGAGGAGGAAGGCTGATATCCTCTGGGGAGCACATCACCTGAAG
GTGCCAAGGAGGAAGGCTGAGAGGGGGGCCACCCCATTTCTGGTACCCAATTTGGTTCTTCAGCCCAACTTGCAAGGGGTTCCTTCTGGT
CCTCCCATCCACTGCCACCTTCCATTTTGTCCATCTCATGCTGGCCTTGGTGGATGGGATGGCTGTATCTAGACAAAATTTTTCTAAAAC
TCCATCAAGGCTCTTATTCAATACCACGTTCCGAGTTGGCCTTTCATCTTCTTTGAGACTGGCCCTGCCTAACCTCTACCATCAATGAGC
TCTTGGCCCTTCTGCCCTTCCCTGTGTTTCTCACTTTCCAACCTAATCCCTGGCTCAGGGTTATTGCCAGTGGAGACTGGTGAGCTGGGC
CTACTCTCAGCTGCCTATCTTCTGCCTTTCACTTGCATCCAACTCCTGGGGCTGGGACCGTAGTAGCTGCGGGGGGGAAGAAACACAGGG
TCGGTGAGCCCAGCATGTGCGTTGGTTTGAGGGGGCGGGCGGTGTGTGTGTGTTCTGGTGGGAGGGATCTGAGCAAGTGCAAGCCTGGCT
GACACAGGTGTGAAGAGGCCATCCTGGAACCCAGGTGAGGGCAAGATGAAGGCTTCCAGGCAGAACAGCTGCAGAGAGTTTGGCTATATG
CATCTGCAGCCCCAAGAGCTCCCACTGCAAGACAAGTGTTGGGGAAGATGGGAGGTTGTGGGTGAGGCCTCTAAAGGTCCTCTCCCAAAC
TGACCAGGCTGATGTCAACCTAACCCCCTCAGGGGCAGGGAACAGGGGAGGGCTCCACAAGCGTGTCTGGCATTCCCACCCACCATGGAA
GACTGGATACGCACCTGGAAACAAAAGGACTATGGAAGCTGTTCAAGATACATTTGATCTTCAGAAAAGCAGAATTTGGTTCAACTGTTG
ACAGAGGACACAAATACGTTGTTCCAGAGCTCAGCCTTCTCACTCTAAAAGAAAGATATTTTTCTATTTATTTTCTACATCTGGCCAGTG
GCTCTGGTGCTAGATGCCACTGTAGCCAGATCTCCAACAGTGCCTTGGACCATGGACTCATACTCAACTGAGTAAGAAGGGGCTGGTGCC
CAGTCGGGGTGGCTGAGCTGGTCCTTAATAGGTTGTTTCTTGGTCTTGCTTTCTTCATGCCCTCCCCACTGCTCCTGCCACCTTTAGATA
AGTTTCTCTAGCTAATTTTGTGGCCAATGTAAAATTCGTCATCAACCTAACAAACACAACCTTCTCAGCAGCATTTCTCCCCTGTGATGG
AAATAAAGTGTTTAGGGCAGTGGGAGGAGAAAATTCTCCAGGTGAATGGGGAAGGGTCTGTTCCAGCCTCTCCCTACTCCCATCCCATTT
CCACCAACTGGGGAACTGTGACTATCTATCTCCCCCGACTTCTACCAGGGATGCCTTCACGCCAAGGCTGTTCTCACCAGCTGCCTCAGA
TGACAAATGAGGCTAATGGACATAATCTACAGTGTCCTTTTTCACTTGCACCTTTTTTATAAGAATATATTGTAATACTAAAAAATATTA

>In-frame_ENST00000373010_ENST00000538976_TCGA-DX-A3LU-01A_USP49_chr6_41766613_-_DAAM2_chr6_39851738_length(amino acids)=1027AA_start in transcript=495_stop in transcript=3578
MDRCKHVGRLRLAQDHSILNPQKWCCLECATTESVWACLKCSHVACGRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVLNDNPEG
DLKLLRSSLLAVRGQKQDTPVRRGRTLRSMASGEDVVLPQRAPQGQPQMLTALWYRRQRLLARTLRLWFEKSSRGQAKLEQRRQEEALER
KKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRDAGPAASRPAALPTSRRVPAATLKLRRQPAMAPGVTGLRNLGNTCYMNSILQV
LSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRE
LHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPFSQRKLTKQVLKVVNTIFHGQLL
SQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEARKQL
MIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKEL
SVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQ
ALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILE
KHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKA
LMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSALR

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Fusion Gene PPI Analysis for USP49-DAAM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP49-DAAM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP49-DAAM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDAAM2C0001787Osteoporosis, Age-Related1CTD_human
TgeneDAAM2C0029456Osteoporosis1CTD_human
TgeneDAAM2C0029459Osteoporosis, Senile1CTD_human
TgeneDAAM2C0036341Schizophrenia1PSYGENET
TgeneDAAM2C0751406Post-Traumatic Osteoporosis1CTD_human