FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:USP54-PSMA6 (FusionGDB2 ID:96926)

Fusion Gene Summary for USP54-PSMA6

check button Fusion gene summary
Fusion gene informationFusion gene name: USP54-PSMA6
Fusion gene ID: 96926
HgeneTgene
Gene symbol

USP54

PSMA6

Gene ID

159195

5687

Gene nameubiquitin specific peptidase 54proteasome 20S subunit alpha 6
SynonymsC10orf29|bA137L10.3|bA137L10.4IOTA|PROS27|p27K
Cytomap

10q22.2

14q13.2

Type of geneprotein-codingprotein-coding
Descriptioninactive ubiquitin carboxyl-terminal hydrolase 54inactive ubiquitin-specific peptidase 54ubiquitin specific protease 54ubiquitin specific proteinase 54proteasome subunit alpha type-627 kDa prosomal proteinPROS-27macropain iota chainmacropain subunit iotamulticatalytic endopeptidase complex iota chainprosomal P27K proteinproteasome (prosome, macropain) subunit, alpha type, 6proteasome iota chain
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000339859, ENST00000408019, 
ENST00000428547, ENST00000394811, 
ENST00000497106, ENST00000422491, 
ENST00000319786, 		ENST00000540871, 
ENST00000261479, ENST00000553809, 
ENST00000555764, ENST00000556506, 
Fusion gene scores* DoF score19 X 13 X 9=222312 X 9 X 7=756
# samples 2012
** MAII scorelog2(20/2223*10)=-3.47443604325227
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/756*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP54 [Title/Abstract] AND PSMA6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP54(75331179)-PSMA6(35786455), # samples:2
Anticipated loss of major functional domain due to fusion event.USP54-PSMA6 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
USP54-PSMA6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across USP54 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PSMA6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-B5-A5OD-01AUSP54chr10

75331179

-PSMA6chr14

35786455

+
ChimerDB4UCECTCGA-B5-A5OD-01AUSP54chr10

75331179

-PSMA6chr14

35786455

+


Top

Fusion Gene ORF analysis for USP54-PSMA6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000339859ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000339859ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000339859ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000339859ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000339859ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000408019ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000408019ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000408019ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000408019ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000408019ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000428547ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000428547ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000428547ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000428547ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000428547ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+
5UTR-3CDSENST00000394811ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
5UTR-3CDSENST00000394811ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
5UTR-3CDSENST00000394811ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
5UTR-3CDSENST00000394811ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
5UTR-3CDSENST00000394811ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000497106ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000497106ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000497106ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000497106ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000497106ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000422491ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000422491ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000422491ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000422491ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000422491ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000319786ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000319786ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000319786ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000319786ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000319786ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339859USP54chr1075331179-ENST00000555764PSMA6chr1435786455+58634110136487
ENST00000408019USP54chr1075331179-ENST00000261479PSMA6chr1435786455+4832571728087
ENST00000408019USP54chr1075331179-ENST00000556506PSMA6chr1435786455+4282571728087
ENST00000428547USP54chr1075331179-ENST00000261479PSMA6chr1435786455+4832571728087
ENST00000428547USP54chr1075331179-ENST00000556506PSMA6chr1435786455+4282571728087
ENST00000319786USP54chr1075331179-ENST00000540871PSMA6chr1435786455+1303108460088494
ENST00000319786USP54chr1075331179-ENST00000553809PSMA6chr1435786455+1183108460088494

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339859ENST00000555764USP54chr1075331179-PSMA6chr1435786455+0.247665180.7523348
ENST00000408019ENST00000261479USP54chr1075331179-PSMA6chr1435786455+0.200297950.79970205
ENST00000408019ENST00000556506USP54chr1075331179-PSMA6chr1435786455+0.147104230.8528958
ENST00000428547ENST00000261479USP54chr1075331179-PSMA6chr1435786455+0.200297950.79970205
ENST00000428547ENST00000556506USP54chr1075331179-PSMA6chr1435786455+0.147104230.8528958
ENST00000319786ENST00000540871USP54chr1075331179-PSMA6chr1435786455+0.186231640.8137683
ENST00000319786ENST00000553809USP54chr1075331179-PSMA6chr1435786455+0.170907960.829092

Top

Fusion Genomic Features for USP54-PSMA6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USP54chr1075331178-PSMA6chr1435786454+1.62E-101
USP54chr1075331178-PSMA6chr1435786454+1.62E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for USP54-PSMA6


check button Go to

FGviewer for the breakpoints of chr10:75331179-chr14:35786455

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP54chr10:75331179chr14:35786455ENST00000339859-323736_77080.01685.0Coiled coilOntology_term=ECO:0000255
HgeneUSP54chr10:75331179chr14:35786455ENST00000394811-221736_7700726.0Coiled coilOntology_term=ECO:0000255
HgeneUSP54chr10:75331179chr14:35786455ENST00000408019-222736_77080.01685.0Coiled coilOntology_term=ECO:0000255
HgeneUSP54chr10:75331179chr14:35786455ENST00000428547-218736_77080.01535.0Coiled coilOntology_term=ECO:0000255
HgeneUSP54chr10:75331179chr14:35786455ENST00000339859-323559_57080.01685.0Compositional biasNote=Poly-Ser
HgeneUSP54chr10:75331179chr14:35786455ENST00000339859-323866_86980.01685.0Compositional biasNote=Poly-Gln
HgeneUSP54chr10:75331179chr14:35786455ENST00000394811-221559_5700726.0Compositional biasNote=Poly-Ser
HgeneUSP54chr10:75331179chr14:35786455ENST00000394811-221866_8690726.0Compositional biasNote=Poly-Gln
HgeneUSP54chr10:75331179chr14:35786455ENST00000408019-222559_57080.01685.0Compositional biasNote=Poly-Ser
HgeneUSP54chr10:75331179chr14:35786455ENST00000408019-222866_86980.01685.0Compositional biasNote=Poly-Gln
HgeneUSP54chr10:75331179chr14:35786455ENST00000428547-218559_57080.01535.0Compositional biasNote=Poly-Ser
HgeneUSP54chr10:75331179chr14:35786455ENST00000428547-218866_86980.01535.0Compositional biasNote=Poly-Gln
HgeneUSP54chr10:75331179chr14:35786455ENST00000339859-32331_35280.01685.0DomainNote=USP
HgeneUSP54chr10:75331179chr14:35786455ENST00000394811-22131_3520726.0DomainNote=USP
HgeneUSP54chr10:75331179chr14:35786455ENST00000408019-22231_35280.01685.0DomainNote=USP
HgeneUSP54chr10:75331179chr14:35786455ENST00000428547-21831_35280.01535.0DomainNote=USP


Top

Fusion Gene Sequence for USP54-PSMA6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000339859_ENST00000555764_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(transcript)=586nt_BP=341nt
GTTTACGGAGACTCGGAACTGGATAAAGGGACCAGGCTACATTGGGAAAGAAGTGGGAAGAAATGGGGTACAGCGACGAGGAGGGCTAAA
TGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAACCTCCA
TAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGGATATCT
TCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAAGCAGAG
ATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTTGG
TAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCACCGAAGTGGTTAGGACTCTATATA

>In-frame_ENST00000339859_ENST00000555764_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(amino acids)=87AA_start in transcript=101_stop in transcript=364

--------------------------------------------------------------
>In-frame_ENST00000408019_ENST00000261479_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(transcript)=483nt_BP=257nt
GCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAA
CCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGG
ATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAA
GCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGT
GTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCACCGAAGTGGTTAGGACTC

>In-frame_ENST00000408019_ENST00000261479_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(amino acids)=87AA_start in transcript=17_stop in transcript=280

--------------------------------------------------------------
>In-frame_ENST00000408019_ENST00000556506_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(transcript)=428nt_BP=257nt
GCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAA
CCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGG
ATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAA
GCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGT

>In-frame_ENST00000408019_ENST00000556506_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(amino acids)=87AA_start in transcript=17_stop in transcript=280

--------------------------------------------------------------
>In-frame_ENST00000428547_ENST00000261479_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(transcript)=483nt_BP=257nt
GCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAA
CCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGG
ATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAA
GCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGT
GTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCACCGAAGTGGTTAGGACTC

>In-frame_ENST00000428547_ENST00000261479_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(amino acids)=87AA_start in transcript=17_stop in transcript=280

--------------------------------------------------------------
>In-frame_ENST00000428547_ENST00000556506_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(transcript)=428nt_BP=257nt
GCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAA
CCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGG
ATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAA
GCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGT

>In-frame_ENST00000428547_ENST00000556506_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(amino acids)=87AA_start in transcript=17_stop in transcript=280

--------------------------------------------------------------
>In-frame_ENST00000319786_ENST00000540871_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(transcript)=1303nt_BP=1084nt
AACTTTGTCATGAATTGTCAGTGCTGAGTTCCTGGTAGTTGGTAAAAAGAATTGCCTTCTCTCTGATATCCTGTTCTGCGGGAAGTCCTT
GTGGTTTAGATTCACAGTTTCTCATTGTTGCTAGCTACAGTCGTCTCCTCCCTCCTAGCCTTCCCTCCCCACAGCTCTAGCTATTCCCAT
ATCCCTCCCCATTCTTGTATCACTTGCCCCACAGATACCCTCGTGATTAGAGGTCTTTTGCTGGAGGTTGACTGTGCTGTCTGCTCTCTG
ACACAGCTGGCTATTCTAGTCCCAGAAGAAAGAGGAGAGACTTGCTGAAGATCTGGATGGGACAATAGAAGTTTGGGGCACATTAAAAAG
AAGCAGCAAGAACATCAACAAAAACCTCAGATGATTCAAACAGGCTTCTTCTTGGCTTTGTGGAACCTTTTGCAGTTGCTCAGAATTTGA
GTTTTTGCTTCAGAGGATGATGAGACAAGGCAATAGAGGGTGAGGAGGATCATGTTGGATTCTTGCTTCTCTGTCTGCCTCTCCTTCCAG
TTGGAAAAATCTTCAGTCCATAAGAAGCATTATCAACAAGCCTGAAGAACACATCTTACCCTGATCCTGGATGCTGTTGGAGTTGAGAAT
TACATCCACTTCACCAGGACTTTATGGAGGCTGTTCAAGAAAAATAGAAGGAAGCAATACTTAAGGATTTCTCTGTTTGCATTAGTCCTG
TGCCATGTTACATTTTGGAGATTGTTTGGAACAAGTGAGGGAGGGCTCTGTCATCTTGATCTAGGAGGATACCTGAGTCCCTTGACTACA
CAGATGATATTTGGAAGGCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTT
TGCACCTCGAAGCTCAACCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCA
GGTTTTGTGGCACTTGGATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCT
CAAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTG
ATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCAC

>In-frame_ENST00000319786_ENST00000540871_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(amino acids)=94AA_start in transcript=600_stop in transcript=884
MILDAVGVENYIHFTRTLWRLFKKNRRKQYLRISLFALVLCHVTFWRLFGTSEGGLCHLDLGGYLSPLTTQMIFGRLNVNNNVLEEKLFF

--------------------------------------------------------------
>In-frame_ENST00000319786_ENST00000553809_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(transcript)=1183nt_BP=1084nt
AACTTTGTCATGAATTGTCAGTGCTGAGTTCCTGGTAGTTGGTAAAAAGAATTGCCTTCTCTCTGATATCCTGTTCTGCGGGAAGTCCTT
GTGGTTTAGATTCACAGTTTCTCATTGTTGCTAGCTACAGTCGTCTCCTCCCTCCTAGCCTTCCCTCCCCACAGCTCTAGCTATTCCCAT
ATCCCTCCCCATTCTTGTATCACTTGCCCCACAGATACCCTCGTGATTAGAGGTCTTTTGCTGGAGGTTGACTGTGCTGTCTGCTCTCTG
ACACAGCTGGCTATTCTAGTCCCAGAAGAAAGAGGAGAGACTTGCTGAAGATCTGGATGGGACAATAGAAGTTTGGGGCACATTAAAAAG
AAGCAGCAAGAACATCAACAAAAACCTCAGATGATTCAAACAGGCTTCTTCTTGGCTTTGTGGAACCTTTTGCAGTTGCTCAGAATTTGA
GTTTTTGCTTCAGAGGATGATGAGACAAGGCAATAGAGGGTGAGGAGGATCATGTTGGATTCTTGCTTCTCTGTCTGCCTCTCCTTCCAG
TTGGAAAAATCTTCAGTCCATAAGAAGCATTATCAACAAGCCTGAAGAACACATCTTACCCTGATCCTGGATGCTGTTGGAGTTGAGAAT
TACATCCACTTCACCAGGACTTTATGGAGGCTGTTCAAGAAAAATAGAAGGAAGCAATACTTAAGGATTTCTCTGTTTGCATTAGTCCTG
TGCCATGTTACATTTTGGAGATTGTTTGGAACAAGTGAGGGAGGGCTCTGTCATCTTGATCTAGGAGGATACCTGAGTCCCTTGACTACA
CAGATGATATTTGGAAGGCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTT
TGCACCTCGAAGCTCAACCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCA
GGTTTTGTGGCACTTGGATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCT
CAAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTG

>In-frame_ENST00000319786_ENST00000553809_TCGA-B5-A5OD-01A_USP54_chr10_75331179_-_PSMA6_chr14_35786455_length(amino acids)=94AA_start in transcript=600_stop in transcript=884
MILDAVGVENYIHFTRTLWRLFKKNRRKQYLRISLFALVLCHVTFWRLFGTSEGGLCHLDLGGYLSPLTTQMIFGRLNVNNNVLEEKLFF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for USP54-PSMA6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for USP54-PSMA6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for USP54-PSMA6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePSMA6C0019693HIV Infections1CTD_human
TgenePSMA6C0027051Myocardial Infarction1CTD_human
TgenePSMA6C4505456HIV Coinfection1CTD_human