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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USP6-PTRH2 (FusionGDB2 ID:96932)

Fusion Gene Summary for USP6-PTRH2

check button Fusion gene summary
Fusion gene informationFusion gene name: USP6-PTRH2
Fusion gene ID: 96932
HgeneTgene
Gene symbol

USP6

PTRH2

Gene ID

9098

51651

Gene nameubiquitin specific peptidase 6peptidyl-tRNA hydrolase 2
SynonymsHRP1|TRE17|TRE2|TRESMCR|Tre-2|USP6-shortBIT1|CFAP37|CGI-147|IMNEPD|PTH|PTH 2|PTH2
Cytomap

17p13.2

17q23.1

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 6TBC1D3 and USP32 fusiondeubiquitinating enzyme 6hyperpolymorphic gene 1proto-oncogene TRE-2ubiquitin specific peptidase 6 (Tre-2 oncogene)ubiquitin specific protease 6 (Tre-2 oncogene)ubiquitin thioesterase 6peptidyl-tRNA hydrolase 2, mitochondrialbcl-2 inhibitor of transcription 1cilia and flagella associated protein 37
Modification date2020032220200313
UniProtAcc

USP6NL

.
Ensembl transtripts involved in fusion geneENST00000332776, ENST00000574788, 
ENST00000304328, ENST00000250066, 
ENST00000572429, 		ENST00000393038, 
ENST00000537860, ENST00000409433, 
ENST00000470557, ENST00000579915, 
Fusion gene scores* DoF score4 X 1 X 1=49 X 6 X 6=324
# samples 512
** MAII scorelog2(5/4*10)=3.64385618977473log2(12/324*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP6 [Title/Abstract] AND PTRH2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSP6(5052062)-PTRH2(57775339), # samples:1
Anticipated loss of major functional domain due to fusion event.USP6-PTRH2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
USP6-PTRH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
USP6-PTRH2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP6

GO:0016579

protein deubiquitination

16127172

HgeneUSP6

GO:0060627

regulation of vesicle-mediated transport

15509780


check buttonFusion gene breakpoints across USP6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PTRH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A3XZUSP6chr17

5052062

+PTRH2chr17

57775339

-


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Fusion Gene ORF analysis for USP6-PTRH2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000332776ENST00000393038USP6chr17

5052062

+PTRH2chr17

57775339

-
3UTR-3CDSENST00000332776ENST00000537860USP6chr17

5052062

+PTRH2chr17

57775339

-
3UTR-3CDSENST00000332776ENST00000409433USP6chr17

5052062

+PTRH2chr17

57775339

-
3UTR-3CDSENST00000332776ENST00000470557USP6chr17

5052062

+PTRH2chr17

57775339

-
3UTR-intronENST00000332776ENST00000579915USP6chr17

5052062

+PTRH2chr17

57775339

-
Frame-shiftENST00000574788ENST00000393038USP6chr17

5052062

+PTRH2chr17

57775339

-
Frame-shiftENST00000574788ENST00000537860USP6chr17

5052062

+PTRH2chr17

57775339

-
In-frameENST00000574788ENST00000409433USP6chr17

5052062

+PTRH2chr17

57775339

-
In-frameENST00000574788ENST00000470557USP6chr17

5052062

+PTRH2chr17

57775339

-
5CDS-intronENST00000574788ENST00000579915USP6chr17

5052062

+PTRH2chr17

57775339

-
Frame-shiftENST00000304328ENST00000393038USP6chr17

5052062

+PTRH2chr17

57775339

-
Frame-shiftENST00000304328ENST00000537860USP6chr17

5052062

+PTRH2chr17

57775339

-
In-frameENST00000304328ENST00000409433USP6chr17

5052062

+PTRH2chr17

57775339

-
In-frameENST00000304328ENST00000470557USP6chr17

5052062

+PTRH2chr17

57775339

-
5CDS-intronENST00000304328ENST00000579915USP6chr17

5052062

+PTRH2chr17

57775339

-
Frame-shiftENST00000250066ENST00000393038USP6chr17

5052062

+PTRH2chr17

57775339

-
Frame-shiftENST00000250066ENST00000537860USP6chr17

5052062

+PTRH2chr17

57775339

-
In-frameENST00000250066ENST00000409433USP6chr17

5052062

+PTRH2chr17

57775339

-
In-frameENST00000250066ENST00000470557USP6chr17

5052062

+PTRH2chr17

57775339

-
5CDS-intronENST00000250066ENST00000579915USP6chr17

5052062

+PTRH2chr17

57775339

-
intron-3CDSENST00000572429ENST00000393038USP6chr17

5052062

+PTRH2chr17

57775339

-
intron-3CDSENST00000572429ENST00000537860USP6chr17

5052062

+PTRH2chr17

57775339

-
intron-3CDSENST00000572429ENST00000409433USP6chr17

5052062

+PTRH2chr17

57775339

-
intron-3CDSENST00000572429ENST00000470557USP6chr17

5052062

+PTRH2chr17

57775339

-
intron-intronENST00000572429ENST00000579915USP6chr17

5052062

+PTRH2chr17

57775339

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000574788USP6chr175052062+ENST00000409433PTRH2chr1757775339-55444873219454121072
ENST00000574788USP6chr175052062+ENST00000470557PTRH2chr1757775339-55404873219454121072
ENST00000304328USP6chr175052062+ENST00000409433PTRH2chr1757775339-5224455328615092743
ENST00000304328USP6chr175052062+ENST00000470557PTRH2chr1757775339-5220455328615092743
ENST00000250066USP6chr175052062+ENST00000409433PTRH2chr1757775339-50134342166348811072
ENST00000250066USP6chr175052062+ENST00000470557PTRH2chr1757775339-50094342166348811072

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000574788ENST00000409433USP6chr175052062+PTRH2chr1757775339-0.0133737530.9866262
ENST00000574788ENST00000470557USP6chr175052062+PTRH2chr1757775339-0.013567260.98643273
ENST00000304328ENST00000409433USP6chr175052062+PTRH2chr1757775339-0.0064861120.9935138
ENST00000304328ENST00000470557USP6chr175052062+PTRH2chr1757775339-0.0066069650.993393
ENST00000250066ENST00000409433USP6chr175052062+PTRH2chr1757775339-0.006156530.99384344
ENST00000250066ENST00000470557USP6chr175052062+PTRH2chr1757775339-0.0062597050.9937403

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Fusion Genomic Features for USP6-PTRH2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USP6-PTRH2


check button Go to

FGviewer for the breakpoints of chr17:5052062-chr17:57775339

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP6

USP6NL

.
828FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP6chr17:5052062chr17:57775339ENST00000250066+2230100_292881.01407.0DomainRab-GAP TBC
HgeneUSP6chr17:5052062chr17:57775339ENST00000304328+2331100_292564.01090.0DomainRab-GAP TBC
HgeneUSP6chr17:5052062chr17:57775339ENST00000332776+2937100_292843.66666666666661292.0DomainRab-GAP TBC
HgeneUSP6chr17:5052062chr17:57775339ENST00000574788+3038100_292881.01407.0DomainRab-GAP TBC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUSP6chr17:5052062chr17:57775339ENST00000250066+2230532_1369881.01407.0DomainNote=USP
HgeneUSP6chr17:5052062chr17:57775339ENST00000304328+2331532_1369564.01090.0DomainNote=USP
HgeneUSP6chr17:5052062chr17:57775339ENST00000332776+2937532_1369843.66666666666661292.0DomainNote=USP
HgeneUSP6chr17:5052062chr17:57775339ENST00000574788+3038532_1369881.01407.0DomainNote=USP


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Fusion Gene Sequence for USP6-PTRH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000574788_ENST00000409433_TCGA-A2-A3XZ_USP6_chr17_5052062_+_PTRH2_chr17_57775339_length(transcript)=5544nt_BP=4873nt
GCCGCCGTCTCGTGTGGTGTCTGAGGGGCGTCTACCTGGAGTCACTGAGCCGACGAAAGGGAAAAGGCCAGTGCCTGTCCGGGAAGAGCT
CAGCCTAGTGGGGCGGGCGACAAGTTACAGTTGCTGCCTTACGATGGCCGTGGCCCGTGGAGGCACTAGACCCTCACCAGGGGTCTGTCA
GGAAAGGCGGGCAGATACGTGAGGCCTGAACAGGAAGGAACTGGGAGACCCAAGACTGTACCGCCAAGACCGCTTTCGAGTCGGGCCGAC
CGGAATTTGAATTCGTTTCTTCACTTACTAGTTGATTTTTTTCCTTGATTCCTTCGTGGGACTCAAGACAGGGGTGCCCTGTTTACTCAG
CCCACTGTGCTCAACCTCTTGCAGGAGTGTGCAGGAAATGAAGGCCCTTTGAGGTCAGGTGGATGAGGATGTCAGTGTGAAGATGGACAC
TGTGCCTGGAGTGAACCTGAGCTGGATCCTGAATGAGATGCATGACCAGGACAAGAAATTGGTGGAGAAGAGCTACAAGGATGCCAAGGG
CTGTTTCTTCAGCATGAGAGAGGGGCTGAACTGCGAGGTGGCCACCAACACAGAGGCCCTGCAGAGCGGCAGGATAGAGATATGGAGCTC
TACATCTCTGTGCAGAACCTGAGCCATCCCAGCTCAGCAAGGTAGGGCCTCTGTCCCCTCCCCACCCTGTACCTATCACCCCAGGGTGAG
CCCAGCCTTATAGACCCCTGCTTGGAGGTGTGTTACGGGACCCAACTGGCCCAGCTGCAGGGGCTCATCAGAAGCATGGAGCAGCAGCTG
TGCGAGCTCTGCTGCGACGCGGAGCACCAGGACCATGAGCACCAGGTCCTTCTGGACGTGAAGACACGGCTGGAGCAGGAGATCGCCACC
TACAGCCGCTTGCTAGAGGTTGAGGACGCTCAAGTCACAGGGAGAAGACGTCCACCCACACATCAGGAGACAGGCCTGGAACAGAGCCTT
CCTGCACAGCCTCAGAAGGGACCCACCCTGGTGACACCTTGATCTTGGACTGACACTCATGACCTCCAGTACTGTGAGACAGTAACATTC
TGTTGTTGAAGGTGCCCAGTCTGTGGTACTGTAAAACAGCCCTGGGAAACTAACGCAGCCTGTTAGCCCACAGATGGTGAAGGGATGGAA
TGCTCCACGGAGCTCCAGGCTTACTATCTACAGCCCCCAAAGTGTGCTGCGGGACCCTTGGGTGGGTGTAGGTATGCAAGGTAATTTTGG
GTGGTTCAAGGTGAATAATTTCAATTGACATAATAATGTATTTATCTTGCTGGGTAAATGAGGGATACCCAACTGTTAGGAACCAGGCAA
CACAGCAGGAGGTGAGCAGCCAGCCAGTGAGCAAAGCTTCATCTGTAGAAACAGCCACTTCCCATCCCTCGCATTACCGCATGAGCTCTG
CCTCCTGTCAGATGAGCGGTGCCGTTAGATTCTCACAGAAGCATGAACCCTACTGTGAACTGCGCATGCCAGGGATCTAGATTGCGTGCT
CCTTATGAGAACCTAATGCCTGATGATCTGTGACTGTCTCATCACTGCCAGATGGAACCACGTAGTTGCAGGAAAACAAGTTCAGGGCTC
CCACTGATTCTACATTATGGCTGGAGTGCAATGGCGCAATCTCGGCTCTCTGCAACTTCCGCCTCCTGGGTTCAAGCAATTCTCCTGCCT
CAGCCTCCCGAGTAGCTGGGACTACAGGCATGTGCCACCATGCCTGGGGCTGTCATTGGGACAGTCTGAGATGGGGAGTCGGGGGAGACA
ATGGATGAATGGATGGATGAATGGACAGCAGTCCAGGGAGATGTCCCTGTGTGTCCTGAACTGGGCCCTTCCTCCAGTGAGAAGCCTTCC
TGAGCTGACTTGGGGACAGTGGCTATGGTATGGGCGGTGTTGGCCTCTGGGCAGCTACAGAGGAGGGTCATCCCTGAGCACTCACCGGGC
GCCCGTTCTACACTGCCCATGTAGACGATTTTCTCTTTCGTCTTCATGGTGGCTTCGTAGAGTGGGTGCTGTTCCCGAATGTACCCATTC
GACAGGAAACTGGGCATCTCTGTGGCCCTGAACATCCCAGGAGGCCGATCGTACAGAGACCTCTGGTGCCTGACCGCAGTTCACATCCAC
ATCCCTGGAATAGACCATCACAGGCTCTTCACCCTTGGCAGGTGGACACCATTCAACCTGCCGGGGCAGGATGGACATGGTAGAGAATGC
AGATAGTTTGCAGGCACAGGAGCGGAAGGACATACTTATGAAGTATGACAAGGGACACCGAGCTGGGCTGCCAGAGGACAAGGGGCCTGA
GCCCGTTGGAATCAACAGCAGCATTGATCGTTTTGGCATTTTGCATGAGACGGAGCTGCCTCCTGTGACTGCACGGGAGGCGAAGAAAAT
TCGGCGGGAGATGACACGAACGAGCAAGTGGATGGAAATGCTGGGAGAATGGGAGACATATAAGCACAGTAGCAAACTCATAGATCGAGT
GTACAAGGGAATTCCCATGAACATCCGGGGCCCGGTGTGGTCAGTCCTCCTGAACATTCAGGAAATCAAGTTGAAAAACCCCGGAAGATA
CCAGATCATGAAGGAGAGGGGCAAGAGGTCATCTGAACACATCCACCACATCGACCTGGACGTGAGGACGACTCTCCGGAACCATGTCTT
CTTTAGGGATCGATATGGAGCCAAGCAGAGGGAACTATTCTACATCCTCCTGGCCTATTCGGAGTATAACCCGGAGGTGGGCTACTGCAG
GGACCTGAGCCACATCACCGCCTTGTTCCTCCTTTATCTGCCTGAGGAGGACGCATTCTGGGCACTGGTGCAGCTGCTGGCCAGTGAGAG
GCACTCCCTGCCAGGATTCCACAGCCCAAATGGTGGGACAGTCCAGGGGCTCCAAGACCAACAGGAGCATGTGGTACCCAAGTCACAACC
CAAGACCATGTGGCATCAGGACAAGGAAGGTCTATGCGGGCAGTGTGCCTCGTTAGGCTGCCTTCTCCGGAACCTGATTGACGGGATCTC
TCTCGGGCTCACCCTGCGCCTGTGGGACGTGTATTTGGTGGAAGGAGAACAGGTGTTGATGCCAATAACCAGCATTGCTCTTAAGGTTCA
GCAGAAGCGCCTCATGAAGACATCCAGGTGTGGCCTGTGGGCACGTCTGCGGAACCAATTCTTCGATACCTGGGCCATGAACGATGACAC
CGTGCTCAAGCATCTTAGGGCCTCTACGAAGAAACTAACAAGGAAGCAAGGGGACCTGCCACCCCCAGCCAAACGCGAGCAAGGGTCCTT
GGCACCCAGGCCTGTGCCGGCTTCACGTGGTGGGAAGACCCTCTGCAAGGGGTATAGGCAGGCCCCTCCAGGCCCACCAGCCCAGTTCCA
GCGGCCCATTTGCTCAGCTTCCCCGCCATGGGCATCTCGTTTTTCCACGCCCTGTCCTGGTGGGGCTGTCCGGGAAGACACGTACCCTGT
GGGCACTCAGGGTGTGCCCAGCCTGGCCCTGGCTCAGGGAGGACCTCAGGGTTCCTGGAGATTCCTGGAGTGGAAGTCAATGCCCCGGCT
CCCAACGGACCTGGATATAGGGGGCCCTTGGTTCCCCCATTATGATTTTGAATGGAGCTGCTGGGTCCGTGCCATATCCCAGGAGGACCA
GCTGGCCACCTGCTGGCAGGCTGAACACTGCGGAGAGGTTCACAACAAAGATATGAGTTGGCCTGAGGAGATGTCTTTTACAGCAAATAG
TAGTAAAATAGATAGACAAAAGGTTCCCACAGAAAAGGGAGCCACAGGTCTAAGCAACCTGGGAAACACATGCTTCATGAACTCAAGCAT
CCAGTGCGTTAGTAACACACAGCCACTGACACAGTATTTTATCTCAGGGAGACATCTTTATGAACTCAACAGGACAAATCCCATTGGTAT
GAAGGGGCATATGGCTAAATGCTATGGTGATTTAGTGCAGGAACTCTGGAGTGGAACTCAGAAGAGTGTTGCCCCATTAAAGCTTCGGCG
GACCATAGCAAAATATGCTCCCAAGTTTGATGGGTTTCAGCAACAAGACTCCCAAGAACTTCTGGCTTTTCTCTTGGATGGTCTTCATGA
AGATCTCAACCGAGTCCATGAAAAGCCATATGTGGAACTGAAGGACAGTGATGGCCGACCAGACTGGGAAGTAGCTGCAGAGGCCTGGGA
CAACCATCTAAGAAGAAATAGATCAATTATTGTGGATTTGTTCCATGGGCAGCTAAGATCTCAAGTCAAATGCAAGACATGTGGGCATAT
AAGTGTCCGATTTGACCCTTTCAATTTTTTGTCTTTGCCACTACCAATGGACAGTTACATGGACTTAGAAATAACAGTGATTAAGTTAGA
TGGTACTACCCCTGTACGGTATGGACTAAGACTGAATATGGATGAAAAGTACACAGGTTTAAAAAAACAGCTGAGGGATCTCTGTGGACT
TAATTCAGAACAAATCCTACTAGCAGAAGTACATGATTCCAACATAAAGAACTTTCCTCAGGATAACCAAAAAGTACAACTCTCAGTGAG
CGGATTTTTGTGTGCATTTGAAATTCCTGTCCCTTCATCTCCAATTTCAGCTTCTAGTCCAACACAAATAGATTTCTCCTCTTCACCATC
TACAAATGGAATGTTCACCCTAACTACCAATGGGGACCTACCCAAACCAATATTCATCCCCAATGGAATGCCAAACACTGTTGTGCCATG
TGGAACTGAGAAGAACTTCACAAATGGAATGGTTAATGGTCACATGCCATCTCTTCCTGACAGCCCCTTTACAGGTTACATCATTGCAGT
CCACCGAAAAATGATGCCCTCCAAATCCTTGGTTATGGAATATTTGGCTCATCCCAGTACACTCGGCTTGGCTGTTGGAGTTGCTTGTGG
CATGTGCCTGGGCTGGAGCCTTCGAGTATGCTTTGGGATGCTCCCCAAAAGCAAGACGAGCAAGACACACACAGATACTGAAAGTGAAGC
AAGCATCTTGGGAGACAGCGGGGAGTACAAGATGATTCTTGTGGTTCGAAATGACTTAAAGATGGGAAAAGGGAAAGTGGCTGCCCAGTG
CTCTCATGCTGCTGTTTCAGCCTACAAGCAGATTCAAAGAAGAAATCCTGAAATGCTCAAACAATGGGAATACTGTGGCCAGCCCAAGGT
GGTGGTCAAAGCTCCTGATGAAGAAACCCTGATTGCATTATTGGCCCATGCAAAAATGCTGGGACTGACTGTAAGTTTAATTCAAGATGC
TGGACGTACTCAGATTGCACCAGGCTCTCAAACTGTCCTAGGGATTGGGCCAGGACCAGCAGACCTAATTGACAAAGTCACTGGTCACCT
AAAACTTTACTAGGTGGACTTTGATATGACAACAACCCCTCCATCACAAGTGTTTGAAGCCTGTCAGATTCTAACAACAAAAGCTGAATT

>In-frame_ENST00000574788_ENST00000409433_TCGA-A2-A3XZ_USP6_chr17_5052062_+_PTRH2_chr17_57775339_length(amino acids)=1072AA_start in transcript=2194_stop in transcript=5412
MAGGHHSTCRGRMDMVENADSLQAQERKDILMKYDKGHRAGLPEDKGPEPVGINSSIDRFGILHETELPPVTAREAKKIRREMTRTSKWM
EMLGEWETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRE
LFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQDKEGL
CGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMNDDTVLKHLRASTKK
LTRKQGDLPPPAKREQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPWASRFSTPCPGGAVREDTYPVGTQGVPSLALA
QGGPQGSWRFLEWKSMPRLPTDLDIGGPWFPHYDFEWSCWVRAISQEDQLATCWQAEHCGEVHNKDMSWPEEMSFTANSSKIDRQKVPTE
KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDG
FQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLS
LPLPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVHDSNIKNFPQDNQKVQLSVSGFLCAFEIPVP
SSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVHRKMMPSKSLV
MEYLAHPSTLGLAVGVACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILGDSGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQI

--------------------------------------------------------------
>In-frame_ENST00000574788_ENST00000470557_TCGA-A2-A3XZ_USP6_chr17_5052062_+_PTRH2_chr17_57775339_length(transcript)=5540nt_BP=4873nt
GCCGCCGTCTCGTGTGGTGTCTGAGGGGCGTCTACCTGGAGTCACTGAGCCGACGAAAGGGAAAAGGCCAGTGCCTGTCCGGGAAGAGCT
CAGCCTAGTGGGGCGGGCGACAAGTTACAGTTGCTGCCTTACGATGGCCGTGGCCCGTGGAGGCACTAGACCCTCACCAGGGGTCTGTCA
GGAAAGGCGGGCAGATACGTGAGGCCTGAACAGGAAGGAACTGGGAGACCCAAGACTGTACCGCCAAGACCGCTTTCGAGTCGGGCCGAC
CGGAATTTGAATTCGTTTCTTCACTTACTAGTTGATTTTTTTCCTTGATTCCTTCGTGGGACTCAAGACAGGGGTGCCCTGTTTACTCAG
CCCACTGTGCTCAACCTCTTGCAGGAGTGTGCAGGAAATGAAGGCCCTTTGAGGTCAGGTGGATGAGGATGTCAGTGTGAAGATGGACAC
TGTGCCTGGAGTGAACCTGAGCTGGATCCTGAATGAGATGCATGACCAGGACAAGAAATTGGTGGAGAAGAGCTACAAGGATGCCAAGGG
CTGTTTCTTCAGCATGAGAGAGGGGCTGAACTGCGAGGTGGCCACCAACACAGAGGCCCTGCAGAGCGGCAGGATAGAGATATGGAGCTC
TACATCTCTGTGCAGAACCTGAGCCATCCCAGCTCAGCAAGGTAGGGCCTCTGTCCCCTCCCCACCCTGTACCTATCACCCCAGGGTGAG
CCCAGCCTTATAGACCCCTGCTTGGAGGTGTGTTACGGGACCCAACTGGCCCAGCTGCAGGGGCTCATCAGAAGCATGGAGCAGCAGCTG
TGCGAGCTCTGCTGCGACGCGGAGCACCAGGACCATGAGCACCAGGTCCTTCTGGACGTGAAGACACGGCTGGAGCAGGAGATCGCCACC
TACAGCCGCTTGCTAGAGGTTGAGGACGCTCAAGTCACAGGGAGAAGACGTCCACCCACACATCAGGAGACAGGCCTGGAACAGAGCCTT
CCTGCACAGCCTCAGAAGGGACCCACCCTGGTGACACCTTGATCTTGGACTGACACTCATGACCTCCAGTACTGTGAGACAGTAACATTC
TGTTGTTGAAGGTGCCCAGTCTGTGGTACTGTAAAACAGCCCTGGGAAACTAACGCAGCCTGTTAGCCCACAGATGGTGAAGGGATGGAA
TGCTCCACGGAGCTCCAGGCTTACTATCTACAGCCCCCAAAGTGTGCTGCGGGACCCTTGGGTGGGTGTAGGTATGCAAGGTAATTTTGG
GTGGTTCAAGGTGAATAATTTCAATTGACATAATAATGTATTTATCTTGCTGGGTAAATGAGGGATACCCAACTGTTAGGAACCAGGCAA
CACAGCAGGAGGTGAGCAGCCAGCCAGTGAGCAAAGCTTCATCTGTAGAAACAGCCACTTCCCATCCCTCGCATTACCGCATGAGCTCTG
CCTCCTGTCAGATGAGCGGTGCCGTTAGATTCTCACAGAAGCATGAACCCTACTGTGAACTGCGCATGCCAGGGATCTAGATTGCGTGCT
CCTTATGAGAACCTAATGCCTGATGATCTGTGACTGTCTCATCACTGCCAGATGGAACCACGTAGTTGCAGGAAAACAAGTTCAGGGCTC
CCACTGATTCTACATTATGGCTGGAGTGCAATGGCGCAATCTCGGCTCTCTGCAACTTCCGCCTCCTGGGTTCAAGCAATTCTCCTGCCT
CAGCCTCCCGAGTAGCTGGGACTACAGGCATGTGCCACCATGCCTGGGGCTGTCATTGGGACAGTCTGAGATGGGGAGTCGGGGGAGACA
ATGGATGAATGGATGGATGAATGGACAGCAGTCCAGGGAGATGTCCCTGTGTGTCCTGAACTGGGCCCTTCCTCCAGTGAGAAGCCTTCC
TGAGCTGACTTGGGGACAGTGGCTATGGTATGGGCGGTGTTGGCCTCTGGGCAGCTACAGAGGAGGGTCATCCCTGAGCACTCACCGGGC
GCCCGTTCTACACTGCCCATGTAGACGATTTTCTCTTTCGTCTTCATGGTGGCTTCGTAGAGTGGGTGCTGTTCCCGAATGTACCCATTC
GACAGGAAACTGGGCATCTCTGTGGCCCTGAACATCCCAGGAGGCCGATCGTACAGAGACCTCTGGTGCCTGACCGCAGTTCACATCCAC
ATCCCTGGAATAGACCATCACAGGCTCTTCACCCTTGGCAGGTGGACACCATTCAACCTGCCGGGGCAGGATGGACATGGTAGAGAATGC
AGATAGTTTGCAGGCACAGGAGCGGAAGGACATACTTATGAAGTATGACAAGGGACACCGAGCTGGGCTGCCAGAGGACAAGGGGCCTGA
GCCCGTTGGAATCAACAGCAGCATTGATCGTTTTGGCATTTTGCATGAGACGGAGCTGCCTCCTGTGACTGCACGGGAGGCGAAGAAAAT
TCGGCGGGAGATGACACGAACGAGCAAGTGGATGGAAATGCTGGGAGAATGGGAGACATATAAGCACAGTAGCAAACTCATAGATCGAGT
GTACAAGGGAATTCCCATGAACATCCGGGGCCCGGTGTGGTCAGTCCTCCTGAACATTCAGGAAATCAAGTTGAAAAACCCCGGAAGATA
CCAGATCATGAAGGAGAGGGGCAAGAGGTCATCTGAACACATCCACCACATCGACCTGGACGTGAGGACGACTCTCCGGAACCATGTCTT
CTTTAGGGATCGATATGGAGCCAAGCAGAGGGAACTATTCTACATCCTCCTGGCCTATTCGGAGTATAACCCGGAGGTGGGCTACTGCAG
GGACCTGAGCCACATCACCGCCTTGTTCCTCCTTTATCTGCCTGAGGAGGACGCATTCTGGGCACTGGTGCAGCTGCTGGCCAGTGAGAG
GCACTCCCTGCCAGGATTCCACAGCCCAAATGGTGGGACAGTCCAGGGGCTCCAAGACCAACAGGAGCATGTGGTACCCAAGTCACAACC
CAAGACCATGTGGCATCAGGACAAGGAAGGTCTATGCGGGCAGTGTGCCTCGTTAGGCTGCCTTCTCCGGAACCTGATTGACGGGATCTC
TCTCGGGCTCACCCTGCGCCTGTGGGACGTGTATTTGGTGGAAGGAGAACAGGTGTTGATGCCAATAACCAGCATTGCTCTTAAGGTTCA
GCAGAAGCGCCTCATGAAGACATCCAGGTGTGGCCTGTGGGCACGTCTGCGGAACCAATTCTTCGATACCTGGGCCATGAACGATGACAC
CGTGCTCAAGCATCTTAGGGCCTCTACGAAGAAACTAACAAGGAAGCAAGGGGACCTGCCACCCCCAGCCAAACGCGAGCAAGGGTCCTT
GGCACCCAGGCCTGTGCCGGCTTCACGTGGTGGGAAGACCCTCTGCAAGGGGTATAGGCAGGCCCCTCCAGGCCCACCAGCCCAGTTCCA
GCGGCCCATTTGCTCAGCTTCCCCGCCATGGGCATCTCGTTTTTCCACGCCCTGTCCTGGTGGGGCTGTCCGGGAAGACACGTACCCTGT
GGGCACTCAGGGTGTGCCCAGCCTGGCCCTGGCTCAGGGAGGACCTCAGGGTTCCTGGAGATTCCTGGAGTGGAAGTCAATGCCCCGGCT
CCCAACGGACCTGGATATAGGGGGCCCTTGGTTCCCCCATTATGATTTTGAATGGAGCTGCTGGGTCCGTGCCATATCCCAGGAGGACCA
GCTGGCCACCTGCTGGCAGGCTGAACACTGCGGAGAGGTTCACAACAAAGATATGAGTTGGCCTGAGGAGATGTCTTTTACAGCAAATAG
TAGTAAAATAGATAGACAAAAGGTTCCCACAGAAAAGGGAGCCACAGGTCTAAGCAACCTGGGAAACACATGCTTCATGAACTCAAGCAT
CCAGTGCGTTAGTAACACACAGCCACTGACACAGTATTTTATCTCAGGGAGACATCTTTATGAACTCAACAGGACAAATCCCATTGGTAT
GAAGGGGCATATGGCTAAATGCTATGGTGATTTAGTGCAGGAACTCTGGAGTGGAACTCAGAAGAGTGTTGCCCCATTAAAGCTTCGGCG
GACCATAGCAAAATATGCTCCCAAGTTTGATGGGTTTCAGCAACAAGACTCCCAAGAACTTCTGGCTTTTCTCTTGGATGGTCTTCATGA
AGATCTCAACCGAGTCCATGAAAAGCCATATGTGGAACTGAAGGACAGTGATGGCCGACCAGACTGGGAAGTAGCTGCAGAGGCCTGGGA
CAACCATCTAAGAAGAAATAGATCAATTATTGTGGATTTGTTCCATGGGCAGCTAAGATCTCAAGTCAAATGCAAGACATGTGGGCATAT
AAGTGTCCGATTTGACCCTTTCAATTTTTTGTCTTTGCCACTACCAATGGACAGTTACATGGACTTAGAAATAACAGTGATTAAGTTAGA
TGGTACTACCCCTGTACGGTATGGACTAAGACTGAATATGGATGAAAAGTACACAGGTTTAAAAAAACAGCTGAGGGATCTCTGTGGACT
TAATTCAGAACAAATCCTACTAGCAGAAGTACATGATTCCAACATAAAGAACTTTCCTCAGGATAACCAAAAAGTACAACTCTCAGTGAG
CGGATTTTTGTGTGCATTTGAAATTCCTGTCCCTTCATCTCCAATTTCAGCTTCTAGTCCAACACAAATAGATTTCTCCTCTTCACCATC
TACAAATGGAATGTTCACCCTAACTACCAATGGGGACCTACCCAAACCAATATTCATCCCCAATGGAATGCCAAACACTGTTGTGCCATG
TGGAACTGAGAAGAACTTCACAAATGGAATGGTTAATGGTCACATGCCATCTCTTCCTGACAGCCCCTTTACAGGTTACATCATTGCAGT
CCACCGAAAAATGATGCCCTCCAAATCCTTGGTTATGGAATATTTGGCTCATCCCAGTACACTCGGCTTGGCTGTTGGAGTTGCTTGTGG
CATGTGCCTGGGCTGGAGCCTTCGAGTATGCTTTGGGATGCTCCCCAAAAGCAAGACGAGCAAGACACACACAGATACTGAAAGTGAAGC
AAGCATCTTGGGAGACAGCGGGGAGTACAAGATGATTCTTGTGGTTCGAAATGACTTAAAGATGGGAAAAGGGAAAGTGGCTGCCCAGTG
CTCTCATGCTGCTGTTTCAGCCTACAAGCAGATTCAAAGAAGAAATCCTGAAATGCTCAAACAATGGGAATACTGTGGCCAGCCCAAGGT
GGTGGTCAAAGCTCCTGATGAAGAAACCCTGATTGCATTATTGGCCCATGCAAAAATGCTGGGACTGACTGTAAGTTTAATTCAAGATGC
TGGACGTACTCAGATTGCACCAGGCTCTCAAACTGTCCTAGGGATTGGGCCAGGACCAGCAGACCTAATTGACAAAGTCACTGGTCACCT
AAAACTTTACTAGGTGGACTTTGATATGACAACAACCCCTCCATCACAAGTGTTTGAAGCCTGTCAGATTCTAACAACAAAAGCTGAATT

>In-frame_ENST00000574788_ENST00000470557_TCGA-A2-A3XZ_USP6_chr17_5052062_+_PTRH2_chr17_57775339_length(amino acids)=1072AA_start in transcript=2194_stop in transcript=5412
MAGGHHSTCRGRMDMVENADSLQAQERKDILMKYDKGHRAGLPEDKGPEPVGINSSIDRFGILHETELPPVTAREAKKIRREMTRTSKWM
EMLGEWETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRE
LFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQDKEGL
CGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMNDDTVLKHLRASTKK
LTRKQGDLPPPAKREQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPWASRFSTPCPGGAVREDTYPVGTQGVPSLALA
QGGPQGSWRFLEWKSMPRLPTDLDIGGPWFPHYDFEWSCWVRAISQEDQLATCWQAEHCGEVHNKDMSWPEEMSFTANSSKIDRQKVPTE
KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDG
FQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLS
LPLPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVHDSNIKNFPQDNQKVQLSVSGFLCAFEIPVP
SSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVHRKMMPSKSLV
MEYLAHPSTLGLAVGVACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILGDSGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQI

--------------------------------------------------------------
>In-frame_ENST00000304328_ENST00000409433_TCGA-A2-A3XZ_USP6_chr17_5052062_+_PTRH2_chr17_57775339_length(transcript)=5224nt_BP=4553nt
CTAAAAATACCATTAAGTAATAGTATTAGCTTTTGTATTCTGAGATTCAACAGCAGCAGTCACTTCCCTCCACTCCTATGTGTATCCCAG
GACCACCCTGGGCGGGGAGGGCTGAGGTCAGGGAGGTCTGAAGCTGGTCCTGGGCTCCGGGGGTGACAGTGATGAGGAACTGGGTGCACA
CATGAGTGGGGCAGCCGGGCCTGGCCAGAGAAGCAACACACACGTGCACAGACATGTTTATCCACATACACATGTGCACGCATGTGCACA
AACACATTGCAGGCAGGCATGTTGACGCCTCAGGCAGCGGAGGACCCTGACTCTGGGCCCTGCTGACCCAGGCAAGGCCCCATTGTGATG
CGTGCCATGACCTCAGAATGTCACTGGTGCTTAGCACCTATCCGCTCTCCAGACTGCGTCTGTGTTCTACGGCAGTTACACACACGCAGT
GGTATTCACAAGCGGTTTTGTGGACTCAAAGGTTTTCTCCCTGAGAGGCATAACCCAGGCCAGCTGATTCATCAGAATCAGGTGAGTGTG
ACCTGCTCTCTTCCCTCCAGGCTGACTTGGGGACAGTGGCTATGGTATGGGCGGTGTTGGCCTCTGGGCAGCTACAGAGGAGGGTCATCC
CTGAGCACTCACCGGGCGCCCGTTCTACACTGCCCATGTAGACGATTTTCTCTTTCGTCTTCATGGTGGCTTCGTAGAGTGGGTGCTGTT
CCCGAATGTACCCATTCGACAGGTGAGCCGTCTGGGGTCAGAGAGGCAGTAACTGGCCTGGGAATCCAGACAAGACCCTGGGTTTTGCTC
TCAGCCCTGCTGTGTGCCATGCTAGACTTCAGGCCTCAACCCTGAGACCTCCCTGCTCTAGATCCCAAATCTGCCCAGATTTCCGATCCC
AATGGGGCAGAGCCTGGCCCTGGCAGAGACACTGGGATGGATCCACTGTGGGTGGGGAGGAGGGAAGGGTCCTCAGAACACACCTGGGGC
CTAAGCTGGGTCTTGATGGTCACTGTGGGACCCACTGGACACACACAGTCCCTTGTCTGGGAGTGGCATGGGGAGCCTTCTGCCCTTGGG
CAGTTGTGGAAAGTGAAGGAGCCCTGGAGAGCTGGCTGAGGGGAGACTATCTTCCCTTGTGTTCAAAGGGGTCCAGGCACTGGGGCTCTC
CCCAAGTATTTCTTATTCTGTCTGGCCTCGCTTTCCTTTTGCCCTGAGTATTCTCAGGAGGGACGGTCCATCTAGATGTCCTCCAGGAGC
AAGGACCCACTGTTCTTCATCAGTGACCCAGGAAAATGAAGCCCCCTCCTGTGGGGACAGCTCAGAATGGTGGAGTCCACAGTCCCTCCC
TGAGAGACATGGTTTCCATGAGCACAGTGGCTGCTTTGGAGACAGTAATCATTTTCATCCCCAAAACCAAACACACTCCTGCTCAAATGG
TGTTATTGCTAAAGCAGCTTCACTGGTTAGACTGAAGGGCCATGGTAGCCCAAGTGATGAGCGGGGTAGAATGGAGCAGTCAGGAGAGAT
CTTGTTCCCCGTAGGAAACTGGGCATCTCTGTGGCCCTGAACATCCCAGGAGGCCGATCGTACAGAGACCTCTGGTGCCTGACCGCAGTT
CACATCCACATCCCTGGAATAGACCATCACAGGCTCTTCACCCTTGGCAGGTGGACACCATTCAACCTGCCGGGGCAGGATGGACATGGT
AGAGAATGCAGATAGTTTGCAGGCACAGGAGCGGAAGGACATACTTATGAAGTATGACAAGGGACACCGAGCTGGGCTGCCAGAGGACAA
GGGGCCTGAGCCCGTTGGAATCAACAGCAGCATTGATCGTTTTGGCATTTTGCATGAGACGGAGCTGCCTCCTGTGACTGCACGGGAGGC
GAAGAAAATTCGGCGGGAGATGACACGAACGAGCAAGTGGATGGAAATGCTGGGAGAATGGGAGACATATAAGCACAGTAGCAAACTCAT
AGATCGAGTGTACAAGGGAATTCCCATGAACATCCGGGGCCCGGTGTGGTCAGTCCTCCTGAACATTCAGGAAATCAAGTTGAAAAACCC
CGGAAGATACCAGATCATGAAGGAGAGGGGCAAGAGGTCATCTGAACACATCCACCACATCGACCTGGACGTGAGGACGACTCTCCGGAA
CCATGTCTTCTTTAGGGATCGATATGGAGCCAAGCAGAGGGAACTATTCTACATCCTCCTGGCCTATTCGGAGTATAACCCGGAGGTGGG
CTACTGCAGGGACCTGAGCCACATCACCGCCTTGTTCCTCCTTTATCTGCCTGAGGAGGACGCATTCTGGGCACTGGTGCAGCTGCTGGC
CAGTGAGAGGCACTCCCTGCCAGGATTCCACAGCCCAAATGGTGGGACAGTCCAGGGGCTCCAAGACCAACAGGAGCATGTGGTACCCAA
GTCACAACCCAAGACCATGTGGCATCAGGACAAGGAAGGTCTATGCGGGCAGTGTGCCTCGTTAGGCTGCCTTCTCCGGAACCTGATTGA
CGGGATCTCTCTCGGGCTCACCCTGCGCCTGTGGGACGTGTATTTGGTGGAAGGAGAACAGGTGTTGATGCCAATAACCAGCATTGCTCT
TAAGGTTCAGCAGAAGCGCCTCATGAAGACATCCAGGTGTGGCCTGTGGGCACGTCTGCGGAACCAATTCTTCGATACCTGGGCCATGAA
CGATGACACCGTGCTCAAGCATCTTAGGGCCTCTACGAAGAAACTAACAAGGAAGCAAGGGGACCTGCCACCCCCAGGCCCAACAGCCCT
GGGACGAAGGTGTGTGGCAGGAAGCCCCCAGCCAGTCTGAACCCTGGGGGCAGTCCCAGGAGCCACCCACCATGCCCCAACGGCTTCCCC
ATGCCAGGCAGCACACACCCCTCCCTCTGGGATCAGCAGACTACAGGCGTGTCGTCAGTGTCAGACCACAGGGGCCACACAGAGACCCCA
AGGACTCCAGAGATGCAGCCAAACGCGAGCAAGGGTCCTTGGCACCCAGGCCTGTGCCGGCTTCACGTGGTGGGAAGACCCTCTGCAAGG
GGTATAGGCAGGCCCCTCCAGGCCCACCAGCCCAGTTCCAGCGGCCCATTTGCTCAGCTTCCCCGCCATGGGCATCTCGTTTTTCCACGC
CCTGTCCTGGTGGGGCTGTCCGGGAAGACACGTACCCTGTGGGCACTCAGGGTGTGCCCAGCCTGGCCCTGGCTCAGGGAGGACCTCAGG
GTTCCTGGAGATTCCTGGAGTGGAAGTCAATGCCCCGGCTCCCAACGGACCTGGATATAGGGGGCCCTTGGTTCCCCCATTATGATTTTG
AATGGAGCTGCTGGGTCCGTGCCATATCCCAGGAGGACCAGCTGGCCACCTGCTGGCAGGCTGAACACTGCGGAGAGGTTCACAACAAAG
ATATGAGTTGGCCTGAGGAGATGTCTTTTACAGCAAATAGTAGTAAAATAGATAGACAAAAGGTTCCCACAGAAAAGGGAGCCACAGGTC
TAAGCAACCTGGGAAACACATGCTTCATGAACTCAAGCATCCAGTGCGTTAGTAACACACAGCCACTGACACAGTATTTTATCTCAGGGA
GACATCTTTATGAACTCAACAGGACAAATCCCATTGGTATGAAGGGGCATATGGCTAAATGCTATGGTGATTTAGTGCAGGAACTCTGGA
GTGGAACTCAGAAGAGTGTTGCCCCATTAAAGCTTCGGCGGACCATAGCAAAATATGCTCCCAAGTTTGATGGGTTTCAGCAACAAGACT
CCCAAGAACTTCTGGCTTTTCTCTTGGATGGTCTTCATGAAGATCTCAACCGAGTCCATGAAAAGCCATATGTGGAACTGAAGGACAGTG
ATGGCCGACCAGACTGGGAAGTAGCTGCAGAGGCCTGGGACAACCATCTAAGAAGAAATAGATCAATTATTGTGGATTTGTTCCATGGGC
AGCTAAGATCTCAAGTCAAATGCAAGACATGTGGGCATATAAGTGTCCGATTTGACCCTTTCAATTTTTTGTCTTTGCCACTACCAATGG
ACAGTTACATGGACTTAGAAATAACAGTGATTAAGTTAGATGGTACTACCCCTGTACGGTATGGACTAAGACTGAATATGGATGAAAAGT
ACACAGGTTTAAAAAAACAGCTGAGGGATCTCTGTGGACTTAATTCAGAACAAATCCTACTAGCAGAAGTACATGATTCCAACATAAAGA
ACTTTCCTCAGGATAACCAAAAAGTACAACTCTCAGTGAGCGGATTTTTGTGTGCATTTGAAATTCCTGTCCCTTCATCTCCAATTTCAG
CTTCTAGTCCAACACAAATAGATTTCTCCTCTTCACCATCTACAAATGGAATGTTCACCCTAACTACCAATGGGGACCTACCCAAACCAA
TATTCATCCCCAATGGAATGCCAAACACTGTTGTGCCATGTGGAACTGAGAAGAACTTCACAAATGGAATGGTTAATGGTCACATGCCAT
CTCTTCCTGACAGCCCCTTTACAGGTTACATCATTGCAGTCCACCGAAAAATGATGCCCTCCAAATCCTTGGTTATGGAATATTTGGCTC
ATCCCAGTACACTCGGCTTGGCTGTTGGAGTTGCTTGTGGCATGTGCCTGGGCTGGAGCCTTCGAGTATGCTTTGGGATGCTCCCCAAAA
GCAAGACGAGCAAGACACACACAGATACTGAAAGTGAAGCAAGCATCTTGGGAGACAGCGGGGAGTACAAGATGATTCTTGTGGTTCGAA
ATGACTTAAAGATGGGAAAAGGGAAAGTGGCTGCCCAGTGCTCTCATGCTGCTGTTTCAGCCTACAAGCAGATTCAAAGAAGAAATCCTG
AAATGCTCAAACAATGGGAATACTGTGGCCAGCCCAAGGTGGTGGTCAAAGCTCCTGATGAAGAAACCCTGATTGCATTATTGGCCCATG
CAAAAATGCTGGGACTGACTGTAAGTTTAATTCAAGATGCTGGACGTACTCAGATTGCACCAGGCTCTCAAACTGTCCTAGGGATTGGGC
CAGGACCAGCAGACCTAATTGACAAAGTCACTGGTCACCTAAAACTTTACTAGGTGGACTTTGATATGACAACAACCCCTCCATCACAAG
TGTTTGAAGCCTGTCAGATTCTAACAACAAAAGCTGAATTTCTTCACCCAACTTAAATGTTCTTGAGATGAAAATAAAACCTATTCCCAT

>In-frame_ENST00000304328_ENST00000409433_TCGA-A2-A3XZ_USP6_chr17_5052062_+_PTRH2_chr17_57775339_length(amino acids)=743AA_start in transcript=2861_stop in transcript=5092
MPQRLPHARQHTPLPLGSADYRRVVSVRPQGPHRDPKDSRDAAKREQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPW
ASRFSTPCPGGAVREDTYPVGTQGVPSLALAQGGPQGSWRFLEWKSMPRLPTDLDIGGPWFPHYDFEWSCWVRAISQEDQLATCWQAEHC
GEVHNKDMSWPEEMSFTANSSKIDRQKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGD
LVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSII
VDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEV
HDSNIKNFPQDNQKVQLSVSGFLCAFEIPVPSSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGM
VNGHMPSLPDSPFTGYIIAVHRKMMPSKSLVMEYLAHPSTLGLAVGVACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILGDSGEYK
MILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPEMLKQWEYCGQPKVVVKAPDEETLIALLAHAKMLGLTVSLIQDAGRTQIAPGSQ

--------------------------------------------------------------
>In-frame_ENST00000304328_ENST00000470557_TCGA-A2-A3XZ_USP6_chr17_5052062_+_PTRH2_chr17_57775339_length(transcript)=5220nt_BP=4553nt
CTAAAAATACCATTAAGTAATAGTATTAGCTTTTGTATTCTGAGATTCAACAGCAGCAGTCACTTCCCTCCACTCCTATGTGTATCCCAG
GACCACCCTGGGCGGGGAGGGCTGAGGTCAGGGAGGTCTGAAGCTGGTCCTGGGCTCCGGGGGTGACAGTGATGAGGAACTGGGTGCACA
CATGAGTGGGGCAGCCGGGCCTGGCCAGAGAAGCAACACACACGTGCACAGACATGTTTATCCACATACACATGTGCACGCATGTGCACA
AACACATTGCAGGCAGGCATGTTGACGCCTCAGGCAGCGGAGGACCCTGACTCTGGGCCCTGCTGACCCAGGCAAGGCCCCATTGTGATG
CGTGCCATGACCTCAGAATGTCACTGGTGCTTAGCACCTATCCGCTCTCCAGACTGCGTCTGTGTTCTACGGCAGTTACACACACGCAGT
GGTATTCACAAGCGGTTTTGTGGACTCAAAGGTTTTCTCCCTGAGAGGCATAACCCAGGCCAGCTGATTCATCAGAATCAGGTGAGTGTG
ACCTGCTCTCTTCCCTCCAGGCTGACTTGGGGACAGTGGCTATGGTATGGGCGGTGTTGGCCTCTGGGCAGCTACAGAGGAGGGTCATCC
CTGAGCACTCACCGGGCGCCCGTTCTACACTGCCCATGTAGACGATTTTCTCTTTCGTCTTCATGGTGGCTTCGTAGAGTGGGTGCTGTT
CCCGAATGTACCCATTCGACAGGTGAGCCGTCTGGGGTCAGAGAGGCAGTAACTGGCCTGGGAATCCAGACAAGACCCTGGGTTTTGCTC
TCAGCCCTGCTGTGTGCCATGCTAGACTTCAGGCCTCAACCCTGAGACCTCCCTGCTCTAGATCCCAAATCTGCCCAGATTTCCGATCCC
AATGGGGCAGAGCCTGGCCCTGGCAGAGACACTGGGATGGATCCACTGTGGGTGGGGAGGAGGGAAGGGTCCTCAGAACACACCTGGGGC
CTAAGCTGGGTCTTGATGGTCACTGTGGGACCCACTGGACACACACAGTCCCTTGTCTGGGAGTGGCATGGGGAGCCTTCTGCCCTTGGG
CAGTTGTGGAAAGTGAAGGAGCCCTGGAGAGCTGGCTGAGGGGAGACTATCTTCCCTTGTGTTCAAAGGGGTCCAGGCACTGGGGCTCTC
CCCAAGTATTTCTTATTCTGTCTGGCCTCGCTTTCCTTTTGCCCTGAGTATTCTCAGGAGGGACGGTCCATCTAGATGTCCTCCAGGAGC
AAGGACCCACTGTTCTTCATCAGTGACCCAGGAAAATGAAGCCCCCTCCTGTGGGGACAGCTCAGAATGGTGGAGTCCACAGTCCCTCCC
TGAGAGACATGGTTTCCATGAGCACAGTGGCTGCTTTGGAGACAGTAATCATTTTCATCCCCAAAACCAAACACACTCCTGCTCAAATGG
TGTTATTGCTAAAGCAGCTTCACTGGTTAGACTGAAGGGCCATGGTAGCCCAAGTGATGAGCGGGGTAGAATGGAGCAGTCAGGAGAGAT
CTTGTTCCCCGTAGGAAACTGGGCATCTCTGTGGCCCTGAACATCCCAGGAGGCCGATCGTACAGAGACCTCTGGTGCCTGACCGCAGTT
CACATCCACATCCCTGGAATAGACCATCACAGGCTCTTCACCCTTGGCAGGTGGACACCATTCAACCTGCCGGGGCAGGATGGACATGGT
AGAGAATGCAGATAGTTTGCAGGCACAGGAGCGGAAGGACATACTTATGAAGTATGACAAGGGACACCGAGCTGGGCTGCCAGAGGACAA
GGGGCCTGAGCCCGTTGGAATCAACAGCAGCATTGATCGTTTTGGCATTTTGCATGAGACGGAGCTGCCTCCTGTGACTGCACGGGAGGC
GAAGAAAATTCGGCGGGAGATGACACGAACGAGCAAGTGGATGGAAATGCTGGGAGAATGGGAGACATATAAGCACAGTAGCAAACTCAT
AGATCGAGTGTACAAGGGAATTCCCATGAACATCCGGGGCCCGGTGTGGTCAGTCCTCCTGAACATTCAGGAAATCAAGTTGAAAAACCC
CGGAAGATACCAGATCATGAAGGAGAGGGGCAAGAGGTCATCTGAACACATCCACCACATCGACCTGGACGTGAGGACGACTCTCCGGAA
CCATGTCTTCTTTAGGGATCGATATGGAGCCAAGCAGAGGGAACTATTCTACATCCTCCTGGCCTATTCGGAGTATAACCCGGAGGTGGG
CTACTGCAGGGACCTGAGCCACATCACCGCCTTGTTCCTCCTTTATCTGCCTGAGGAGGACGCATTCTGGGCACTGGTGCAGCTGCTGGC
CAGTGAGAGGCACTCCCTGCCAGGATTCCACAGCCCAAATGGTGGGACAGTCCAGGGGCTCCAAGACCAACAGGAGCATGTGGTACCCAA
GTCACAACCCAAGACCATGTGGCATCAGGACAAGGAAGGTCTATGCGGGCAGTGTGCCTCGTTAGGCTGCCTTCTCCGGAACCTGATTGA
CGGGATCTCTCTCGGGCTCACCCTGCGCCTGTGGGACGTGTATTTGGTGGAAGGAGAACAGGTGTTGATGCCAATAACCAGCATTGCTCT
TAAGGTTCAGCAGAAGCGCCTCATGAAGACATCCAGGTGTGGCCTGTGGGCACGTCTGCGGAACCAATTCTTCGATACCTGGGCCATGAA
CGATGACACCGTGCTCAAGCATCTTAGGGCCTCTACGAAGAAACTAACAAGGAAGCAAGGGGACCTGCCACCCCCAGGCCCAACAGCCCT
GGGACGAAGGTGTGTGGCAGGAAGCCCCCAGCCAGTCTGAACCCTGGGGGCAGTCCCAGGAGCCACCCACCATGCCCCAACGGCTTCCCC
ATGCCAGGCAGCACACACCCCTCCCTCTGGGATCAGCAGACTACAGGCGTGTCGTCAGTGTCAGACCACAGGGGCCACACAGAGACCCCA
AGGACTCCAGAGATGCAGCCAAACGCGAGCAAGGGTCCTTGGCACCCAGGCCTGTGCCGGCTTCACGTGGTGGGAAGACCCTCTGCAAGG
GGTATAGGCAGGCCCCTCCAGGCCCACCAGCCCAGTTCCAGCGGCCCATTTGCTCAGCTTCCCCGCCATGGGCATCTCGTTTTTCCACGC
CCTGTCCTGGTGGGGCTGTCCGGGAAGACACGTACCCTGTGGGCACTCAGGGTGTGCCCAGCCTGGCCCTGGCTCAGGGAGGACCTCAGG
GTTCCTGGAGATTCCTGGAGTGGAAGTCAATGCCCCGGCTCCCAACGGACCTGGATATAGGGGGCCCTTGGTTCCCCCATTATGATTTTG
AATGGAGCTGCTGGGTCCGTGCCATATCCCAGGAGGACCAGCTGGCCACCTGCTGGCAGGCTGAACACTGCGGAGAGGTTCACAACAAAG
ATATGAGTTGGCCTGAGGAGATGTCTTTTACAGCAAATAGTAGTAAAATAGATAGACAAAAGGTTCCCACAGAAAAGGGAGCCACAGGTC
TAAGCAACCTGGGAAACACATGCTTCATGAACTCAAGCATCCAGTGCGTTAGTAACACACAGCCACTGACACAGTATTTTATCTCAGGGA
GACATCTTTATGAACTCAACAGGACAAATCCCATTGGTATGAAGGGGCATATGGCTAAATGCTATGGTGATTTAGTGCAGGAACTCTGGA
GTGGAACTCAGAAGAGTGTTGCCCCATTAAAGCTTCGGCGGACCATAGCAAAATATGCTCCCAAGTTTGATGGGTTTCAGCAACAAGACT
CCCAAGAACTTCTGGCTTTTCTCTTGGATGGTCTTCATGAAGATCTCAACCGAGTCCATGAAAAGCCATATGTGGAACTGAAGGACAGTG
ATGGCCGACCAGACTGGGAAGTAGCTGCAGAGGCCTGGGACAACCATCTAAGAAGAAATAGATCAATTATTGTGGATTTGTTCCATGGGC
AGCTAAGATCTCAAGTCAAATGCAAGACATGTGGGCATATAAGTGTCCGATTTGACCCTTTCAATTTTTTGTCTTTGCCACTACCAATGG
ACAGTTACATGGACTTAGAAATAACAGTGATTAAGTTAGATGGTACTACCCCTGTACGGTATGGACTAAGACTGAATATGGATGAAAAGT
ACACAGGTTTAAAAAAACAGCTGAGGGATCTCTGTGGACTTAATTCAGAACAAATCCTACTAGCAGAAGTACATGATTCCAACATAAAGA
ACTTTCCTCAGGATAACCAAAAAGTACAACTCTCAGTGAGCGGATTTTTGTGTGCATTTGAAATTCCTGTCCCTTCATCTCCAATTTCAG
CTTCTAGTCCAACACAAATAGATTTCTCCTCTTCACCATCTACAAATGGAATGTTCACCCTAACTACCAATGGGGACCTACCCAAACCAA
TATTCATCCCCAATGGAATGCCAAACACTGTTGTGCCATGTGGAACTGAGAAGAACTTCACAAATGGAATGGTTAATGGTCACATGCCAT
CTCTTCCTGACAGCCCCTTTACAGGTTACATCATTGCAGTCCACCGAAAAATGATGCCCTCCAAATCCTTGGTTATGGAATATTTGGCTC
ATCCCAGTACACTCGGCTTGGCTGTTGGAGTTGCTTGTGGCATGTGCCTGGGCTGGAGCCTTCGAGTATGCTTTGGGATGCTCCCCAAAA
GCAAGACGAGCAAGACACACACAGATACTGAAAGTGAAGCAAGCATCTTGGGAGACAGCGGGGAGTACAAGATGATTCTTGTGGTTCGAA
ATGACTTAAAGATGGGAAAAGGGAAAGTGGCTGCCCAGTGCTCTCATGCTGCTGTTTCAGCCTACAAGCAGATTCAAAGAAGAAATCCTG
AAATGCTCAAACAATGGGAATACTGTGGCCAGCCCAAGGTGGTGGTCAAAGCTCCTGATGAAGAAACCCTGATTGCATTATTGGCCCATG
CAAAAATGCTGGGACTGACTGTAAGTTTAATTCAAGATGCTGGACGTACTCAGATTGCACCAGGCTCTCAAACTGTCCTAGGGATTGGGC
CAGGACCAGCAGACCTAATTGACAAAGTCACTGGTCACCTAAAACTTTACTAGGTGGACTTTGATATGACAACAACCCCTCCATCACAAG
TGTTTGAAGCCTGTCAGATTCTAACAACAAAAGCTGAATTTCTTCACCCAACTTAAATGTTCTTGAGATGAAAATAAAACCTATTCCCAT

>In-frame_ENST00000304328_ENST00000470557_TCGA-A2-A3XZ_USP6_chr17_5052062_+_PTRH2_chr17_57775339_length(amino acids)=743AA_start in transcript=2861_stop in transcript=5092
MPQRLPHARQHTPLPLGSADYRRVVSVRPQGPHRDPKDSRDAAKREQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPW
ASRFSTPCPGGAVREDTYPVGTQGVPSLALAQGGPQGSWRFLEWKSMPRLPTDLDIGGPWFPHYDFEWSCWVRAISQEDQLATCWQAEHC
GEVHNKDMSWPEEMSFTANSSKIDRQKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGD
LVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSII
VDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEV
HDSNIKNFPQDNQKVQLSVSGFLCAFEIPVPSSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGM
VNGHMPSLPDSPFTGYIIAVHRKMMPSKSLVMEYLAHPSTLGLAVGVACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILGDSGEYK
MILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPEMLKQWEYCGQPKVVVKAPDEETLIALLAHAKMLGLTVSLIQDAGRTQIAPGSQ

--------------------------------------------------------------
>In-frame_ENST00000250066_ENST00000409433_TCGA-A2-A3XZ_USP6_chr17_5052062_+_PTRH2_chr17_57775339_length(transcript)=5013nt_BP=4342nt
CTAAAAATACCATTAAGTAATAGTATTAGCTTTTGTATTCTGAGATTCAACAGCAGCAGTCACTTCCCTCCACTCCTATGTGTATCCCAG
GACCACCCTGGGCGGGGAGGGCTGAGGTCAGGGAGGTCTGAAGCTGGTCCTGGGCTCCGGGGGTGACAGTGATGAGGAACTGGGTGCACA
CATGAGTGGGGCAGCCGGGCCTGGCCAGAGAAGCAACACACACGTGCACAGACATGTTTATCCACATACACATGTGCACGCATGTGCACA
AACACATTGCAGGCAGGCATGTTGACGCCTCAGGCAGCGGAGGACCCTGACTCTGGGCCCTGCTGACCCAGGCAAGGCCCCATTGTGATG
CGTGCCATGACCTCAGAATGTCACTGGTGCTTAGCACCTATCCGCTCTCCAGACTGCGTCTGTGTTCTACGGCAGTTACACACACGCAGT
GGTATTCACAAGCGGTTTTGTGGACTCAAAGGTTTTCTCCCTGAGAGGCATAACCCAGGCCAGCTGATTCATCAGAATCAGGTGAGTGTG
ACCTGCTCTCTTCCCTCCAGGCTGACTTGGGGACAGTGGCTATGGTATGGGCGGTGTTGGCCTCTGGGCAGCTACAGAGGAGGGTCATCC
CTGAGCACTCACCGGGCGCCCGTTCTACACTGCCCATGTAGACGATTTTCTCTTTCGTCTTCATGGTGGCTTCGTAGAGTGGGTGCTGTT
CCCGAATGTACCCATTCGACAGGTGAGCCGTCTGGGGTCAGAGAGGCAGTAACTGGCCTGGGAATCCAGACAAGACCCTGGGTTTTGCTC
TCAGCCCTGCTGTGTGCCATGCTAGACTTCAGGCCTCAACCCTGAGACCTCCCTGCTCTAGATCCCAAATCTGCCCAGATTTCCGATCCC
AATGGGGCAGAGCCTGGCCCTGGCAGAGACACTGGGATGGATCCACTGTGGGTGGGGAGGAGGGAAGGGTCCTCAGAACACACCTGGGGC
CTAAGCTGGGTCTTGATGGTCACTGTGGGACCCACTGGACACACACAGTCCCTTGTCTGGGAGTGGCATGGGGAGCCTTCTGCCCTTGGG
CAGTTGTGGAAAGTGAAGGAGCCCTGGAGAGCTGGCTGAGGGGAGACTATCTTCCCTTGTGTTCAAAGGGGTCCAGGCACTGGGGCTCTC
CCCAAGTATTTCTTATTCTGTCTGGCCTCGCTTTCCTTTTGCCCTGAGTATTCTCAGGAGGGACGGTCCATCTAGATGTCCTCCAGGAGC
AAGGACCCACTGTTCTTCATCAGTGACCCAGGAAAATGAAGCCCCCTCCTGTGGGGACAGCTCAGAATGGTGGAGTCCACAGTCCCTCCC
TGAGAGACATGGTTTCCATGAGCACAGTGGCTGCTTTGGAGACAGTAATCATTTTCATCCCCAAAACCAAACACACTCCTGCTCAAATGG
TGTTATTGCTAAAGCAGCTTCACTGGTTAGACTGAAGGGCCATGGTAGCCCAAGTGATGAGCGGGGTAGAATGGAGCAGTCAGGAGAGAT
CTTGTTCCCCGTAGGAAACTGGGCATCTCTGTGGCCCTGAACATCCCAGGAGGCCGATCGTACAGAGACCTCTGGTGCCTGACCGCAGTT
CACATCCACATCCCTGGAATAGACCATCACAGGCTCTTCACCCTTGGCAGGTGGACACCATTCAACCTGCCGGGGCAGGATGGACATGGT
AGAGAATGCAGATAGTTTGCAGGCACAGGAGCGGAAGGACATACTTATGAAGTATGACAAGGGACACCGAGCTGGGCTGCCAGAGGACAA
GGGGCCTGAGCCCGTTGGAATCAACAGCAGCATTGATCGTTTTGGCATTTTGCATGAGACGGAGCTGCCTCCTGTGACTGCACGGGAGGC
GAAGAAAATTCGGCGGGAGATGACACGAACGAGCAAGTGGATGGAAATGCTGGGAGAATGGGAGACATATAAGCACAGTAGCAAACTCAT
AGATCGAGTGTACAAGGGAATTCCCATGAACATCCGGGGCCCGGTGTGGTCAGTCCTCCTGAACATTCAGGAAATCAAGTTGAAAAACCC
CGGAAGATACCAGATCATGAAGGAGAGGGGCAAGAGGTCATCTGAACACATCCACCACATCGACCTGGACGTGAGGACGACTCTCCGGAA
CCATGTCTTCTTTAGGGATCGATATGGAGCCAAGCAGAGGGAACTATTCTACATCCTCCTGGCCTATTCGGAGTATAACCCGGAGGTGGG
CTACTGCAGGGACCTGAGCCACATCACCGCCTTGTTCCTCCTTTATCTGCCTGAGGAGGACGCATTCTGGGCACTGGTGCAGCTGCTGGC
CAGTGAGAGGCACTCCCTGCCAGGATTCCACAGCCCAAATGGTGGGACAGTCCAGGGGCTCCAAGACCAACAGGAGCATGTGGTACCCAA
GTCACAACCCAAGACCATGTGGCATCAGGACAAGGAAGGTCTATGCGGGCAGTGTGCCTCGTTAGGCTGCCTTCTCCGGAACCTGATTGA
CGGGATCTCTCTCGGGCTCACCCTGCGCCTGTGGGACGTGTATTTGGTGGAAGGAGAACAGGTGTTGATGCCAATAACCAGCATTGCTCT
TAAGGTTCAGCAGAAGCGCCTCATGAAGACATCCAGGTGTGGCCTGTGGGCACGTCTGCGGAACCAATTCTTCGATACCTGGGCCATGAA
CGATGACACCGTGCTCAAGCATCTTAGGGCCTCTACGAAGAAACTAACAAGGAAGCAAGGGGACCTGCCACCCCCAGCCAAACGCGAGCA
AGGGTCCTTGGCACCCAGGCCTGTGCCGGCTTCACGTGGTGGGAAGACCCTCTGCAAGGGGTATAGGCAGGCCCCTCCAGGCCCACCAGC
CCAGTTCCAGCGGCCCATTTGCTCAGCTTCCCCGCCATGGGCATCTCGTTTTTCCACGCCCTGTCCTGGTGGGGCTGTCCGGGAAGACAC
GTACCCTGTGGGCACTCAGGGTGTGCCCAGCCTGGCCCTGGCTCAGGGAGGACCTCAGGGTTCCTGGAGATTCCTGGAGTGGAAGTCAAT
GCCCCGGCTCCCAACGGACCTGGATATAGGGGGCCCTTGGTTCCCCCATTATGATTTTGAATGGAGCTGCTGGGTCCGTGCCATATCCCA
GGAGGACCAGCTGGCCACCTGCTGGCAGGCTGAACACTGCGGAGAGGTTCACAACAAAGATATGAGTTGGCCTGAGGAGATGTCTTTTAC
AGCAAATAGTAGTAAAATAGATAGACAAAAGGTTCCCACAGAAAAGGGAGCCACAGGTCTAAGCAACCTGGGAAACACATGCTTCATGAA
CTCAAGCATCCAGTGCGTTAGTAACACACAGCCACTGACACAGTATTTTATCTCAGGGAGACATCTTTATGAACTCAACAGGACAAATCC
CATTGGTATGAAGGGGCATATGGCTAAATGCTATGGTGATTTAGTGCAGGAACTCTGGAGTGGAACTCAGAAGAGTGTTGCCCCATTAAA
GCTTCGGCGGACCATAGCAAAATATGCTCCCAAGTTTGATGGGTTTCAGCAACAAGACTCCCAAGAACTTCTGGCTTTTCTCTTGGATGG
TCTTCATGAAGATCTCAACCGAGTCCATGAAAAGCCATATGTGGAACTGAAGGACAGTGATGGCCGACCAGACTGGGAAGTAGCTGCAGA
GGCCTGGGACAACCATCTAAGAAGAAATAGATCAATTATTGTGGATTTGTTCCATGGGCAGCTAAGATCTCAAGTCAAATGCAAGACATG
TGGGCATATAAGTGTCCGATTTGACCCTTTCAATTTTTTGTCTTTGCCACTACCAATGGACAGTTACATGGACTTAGAAATAACAGTGAT
TAAGTTAGATGGTACTACCCCTGTACGGTATGGACTAAGACTGAATATGGATGAAAAGTACACAGGTTTAAAAAAACAGCTGAGGGATCT
CTGTGGACTTAATTCAGAACAAATCCTACTAGCAGAAGTACATGATTCCAACATAAAGAACTTTCCTCAGGATAACCAAAAAGTACAACT
CTCAGTGAGCGGATTTTTGTGTGCATTTGAAATTCCTGTCCCTTCATCTCCAATTTCAGCTTCTAGTCCAACACAAATAGATTTCTCCTC
TTCACCATCTACAAATGGAATGTTCACCCTAACTACCAATGGGGACCTACCCAAACCAATATTCATCCCCAATGGAATGCCAAACACTGT
TGTGCCATGTGGAACTGAGAAGAACTTCACAAATGGAATGGTTAATGGTCACATGCCATCTCTTCCTGACAGCCCCTTTACAGGTTACAT
CATTGCAGTCCACCGAAAAATGATGCCCTCCAAATCCTTGGTTATGGAATATTTGGCTCATCCCAGTACACTCGGCTTGGCTGTTGGAGT
TGCTTGTGGCATGTGCCTGGGCTGGAGCCTTCGAGTATGCTTTGGGATGCTCCCCAAAAGCAAGACGAGCAAGACACACACAGATACTGA
AAGTGAAGCAAGCATCTTGGGAGACAGCGGGGAGTACAAGATGATTCTTGTGGTTCGAAATGACTTAAAGATGGGAAAAGGGAAAGTGGC
TGCCCAGTGCTCTCATGCTGCTGTTTCAGCCTACAAGCAGATTCAAAGAAGAAATCCTGAAATGCTCAAACAATGGGAATACTGTGGCCA
GCCCAAGGTGGTGGTCAAAGCTCCTGATGAAGAAACCCTGATTGCATTATTGGCCCATGCAAAAATGCTGGGACTGACTGTAAGTTTAAT
TCAAGATGCTGGACGTACTCAGATTGCACCAGGCTCTCAAACTGTCCTAGGGATTGGGCCAGGACCAGCAGACCTAATTGACAAAGTCAC
TGGTCACCTAAAACTTTACTAGGTGGACTTTGATATGACAACAACCCCTCCATCACAAGTGTTTGAAGCCTGTCAGATTCTAACAACAAA

>In-frame_ENST00000250066_ENST00000409433_TCGA-A2-A3XZ_USP6_chr17_5052062_+_PTRH2_chr17_57775339_length(amino acids)=1072AA_start in transcript=1663_stop in transcript=4881
MAGGHHSTCRGRMDMVENADSLQAQERKDILMKYDKGHRAGLPEDKGPEPVGINSSIDRFGILHETELPPVTAREAKKIRREMTRTSKWM
EMLGEWETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRE
LFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQDKEGL
CGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMNDDTVLKHLRASTKK
LTRKQGDLPPPAKREQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPWASRFSTPCPGGAVREDTYPVGTQGVPSLALA
QGGPQGSWRFLEWKSMPRLPTDLDIGGPWFPHYDFEWSCWVRAISQEDQLATCWQAEHCGEVHNKDMSWPEEMSFTANSSKIDRQKVPTE
KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDG
FQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLS
LPLPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVHDSNIKNFPQDNQKVQLSVSGFLCAFEIPVP
SSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVHRKMMPSKSLV
MEYLAHPSTLGLAVGVACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILGDSGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQI

--------------------------------------------------------------
>In-frame_ENST00000250066_ENST00000470557_TCGA-A2-A3XZ_USP6_chr17_5052062_+_PTRH2_chr17_57775339_length(transcript)=5009nt_BP=4342nt
CTAAAAATACCATTAAGTAATAGTATTAGCTTTTGTATTCTGAGATTCAACAGCAGCAGTCACTTCCCTCCACTCCTATGTGTATCCCAG
GACCACCCTGGGCGGGGAGGGCTGAGGTCAGGGAGGTCTGAAGCTGGTCCTGGGCTCCGGGGGTGACAGTGATGAGGAACTGGGTGCACA
CATGAGTGGGGCAGCCGGGCCTGGCCAGAGAAGCAACACACACGTGCACAGACATGTTTATCCACATACACATGTGCACGCATGTGCACA
AACACATTGCAGGCAGGCATGTTGACGCCTCAGGCAGCGGAGGACCCTGACTCTGGGCCCTGCTGACCCAGGCAAGGCCCCATTGTGATG
CGTGCCATGACCTCAGAATGTCACTGGTGCTTAGCACCTATCCGCTCTCCAGACTGCGTCTGTGTTCTACGGCAGTTACACACACGCAGT
GGTATTCACAAGCGGTTTTGTGGACTCAAAGGTTTTCTCCCTGAGAGGCATAACCCAGGCCAGCTGATTCATCAGAATCAGGTGAGTGTG
ACCTGCTCTCTTCCCTCCAGGCTGACTTGGGGACAGTGGCTATGGTATGGGCGGTGTTGGCCTCTGGGCAGCTACAGAGGAGGGTCATCC
CTGAGCACTCACCGGGCGCCCGTTCTACACTGCCCATGTAGACGATTTTCTCTTTCGTCTTCATGGTGGCTTCGTAGAGTGGGTGCTGTT
CCCGAATGTACCCATTCGACAGGTGAGCCGTCTGGGGTCAGAGAGGCAGTAACTGGCCTGGGAATCCAGACAAGACCCTGGGTTTTGCTC
TCAGCCCTGCTGTGTGCCATGCTAGACTTCAGGCCTCAACCCTGAGACCTCCCTGCTCTAGATCCCAAATCTGCCCAGATTTCCGATCCC
AATGGGGCAGAGCCTGGCCCTGGCAGAGACACTGGGATGGATCCACTGTGGGTGGGGAGGAGGGAAGGGTCCTCAGAACACACCTGGGGC
CTAAGCTGGGTCTTGATGGTCACTGTGGGACCCACTGGACACACACAGTCCCTTGTCTGGGAGTGGCATGGGGAGCCTTCTGCCCTTGGG
CAGTTGTGGAAAGTGAAGGAGCCCTGGAGAGCTGGCTGAGGGGAGACTATCTTCCCTTGTGTTCAAAGGGGTCCAGGCACTGGGGCTCTC
CCCAAGTATTTCTTATTCTGTCTGGCCTCGCTTTCCTTTTGCCCTGAGTATTCTCAGGAGGGACGGTCCATCTAGATGTCCTCCAGGAGC
AAGGACCCACTGTTCTTCATCAGTGACCCAGGAAAATGAAGCCCCCTCCTGTGGGGACAGCTCAGAATGGTGGAGTCCACAGTCCCTCCC
TGAGAGACATGGTTTCCATGAGCACAGTGGCTGCTTTGGAGACAGTAATCATTTTCATCCCCAAAACCAAACACACTCCTGCTCAAATGG
TGTTATTGCTAAAGCAGCTTCACTGGTTAGACTGAAGGGCCATGGTAGCCCAAGTGATGAGCGGGGTAGAATGGAGCAGTCAGGAGAGAT
CTTGTTCCCCGTAGGAAACTGGGCATCTCTGTGGCCCTGAACATCCCAGGAGGCCGATCGTACAGAGACCTCTGGTGCCTGACCGCAGTT
CACATCCACATCCCTGGAATAGACCATCACAGGCTCTTCACCCTTGGCAGGTGGACACCATTCAACCTGCCGGGGCAGGATGGACATGGT
AGAGAATGCAGATAGTTTGCAGGCACAGGAGCGGAAGGACATACTTATGAAGTATGACAAGGGACACCGAGCTGGGCTGCCAGAGGACAA
GGGGCCTGAGCCCGTTGGAATCAACAGCAGCATTGATCGTTTTGGCATTTTGCATGAGACGGAGCTGCCTCCTGTGACTGCACGGGAGGC
GAAGAAAATTCGGCGGGAGATGACACGAACGAGCAAGTGGATGGAAATGCTGGGAGAATGGGAGACATATAAGCACAGTAGCAAACTCAT
AGATCGAGTGTACAAGGGAATTCCCATGAACATCCGGGGCCCGGTGTGGTCAGTCCTCCTGAACATTCAGGAAATCAAGTTGAAAAACCC
CGGAAGATACCAGATCATGAAGGAGAGGGGCAAGAGGTCATCTGAACACATCCACCACATCGACCTGGACGTGAGGACGACTCTCCGGAA
CCATGTCTTCTTTAGGGATCGATATGGAGCCAAGCAGAGGGAACTATTCTACATCCTCCTGGCCTATTCGGAGTATAACCCGGAGGTGGG
CTACTGCAGGGACCTGAGCCACATCACCGCCTTGTTCCTCCTTTATCTGCCTGAGGAGGACGCATTCTGGGCACTGGTGCAGCTGCTGGC
CAGTGAGAGGCACTCCCTGCCAGGATTCCACAGCCCAAATGGTGGGACAGTCCAGGGGCTCCAAGACCAACAGGAGCATGTGGTACCCAA
GTCACAACCCAAGACCATGTGGCATCAGGACAAGGAAGGTCTATGCGGGCAGTGTGCCTCGTTAGGCTGCCTTCTCCGGAACCTGATTGA
CGGGATCTCTCTCGGGCTCACCCTGCGCCTGTGGGACGTGTATTTGGTGGAAGGAGAACAGGTGTTGATGCCAATAACCAGCATTGCTCT
TAAGGTTCAGCAGAAGCGCCTCATGAAGACATCCAGGTGTGGCCTGTGGGCACGTCTGCGGAACCAATTCTTCGATACCTGGGCCATGAA
CGATGACACCGTGCTCAAGCATCTTAGGGCCTCTACGAAGAAACTAACAAGGAAGCAAGGGGACCTGCCACCCCCAGCCAAACGCGAGCA
AGGGTCCTTGGCACCCAGGCCTGTGCCGGCTTCACGTGGTGGGAAGACCCTCTGCAAGGGGTATAGGCAGGCCCCTCCAGGCCCACCAGC
CCAGTTCCAGCGGCCCATTTGCTCAGCTTCCCCGCCATGGGCATCTCGTTTTTCCACGCCCTGTCCTGGTGGGGCTGTCCGGGAAGACAC
GTACCCTGTGGGCACTCAGGGTGTGCCCAGCCTGGCCCTGGCTCAGGGAGGACCTCAGGGTTCCTGGAGATTCCTGGAGTGGAAGTCAAT
GCCCCGGCTCCCAACGGACCTGGATATAGGGGGCCCTTGGTTCCCCCATTATGATTTTGAATGGAGCTGCTGGGTCCGTGCCATATCCCA
GGAGGACCAGCTGGCCACCTGCTGGCAGGCTGAACACTGCGGAGAGGTTCACAACAAAGATATGAGTTGGCCTGAGGAGATGTCTTTTAC
AGCAAATAGTAGTAAAATAGATAGACAAAAGGTTCCCACAGAAAAGGGAGCCACAGGTCTAAGCAACCTGGGAAACACATGCTTCATGAA
CTCAAGCATCCAGTGCGTTAGTAACACACAGCCACTGACACAGTATTTTATCTCAGGGAGACATCTTTATGAACTCAACAGGACAAATCC
CATTGGTATGAAGGGGCATATGGCTAAATGCTATGGTGATTTAGTGCAGGAACTCTGGAGTGGAACTCAGAAGAGTGTTGCCCCATTAAA
GCTTCGGCGGACCATAGCAAAATATGCTCCCAAGTTTGATGGGTTTCAGCAACAAGACTCCCAAGAACTTCTGGCTTTTCTCTTGGATGG
TCTTCATGAAGATCTCAACCGAGTCCATGAAAAGCCATATGTGGAACTGAAGGACAGTGATGGCCGACCAGACTGGGAAGTAGCTGCAGA
GGCCTGGGACAACCATCTAAGAAGAAATAGATCAATTATTGTGGATTTGTTCCATGGGCAGCTAAGATCTCAAGTCAAATGCAAGACATG
TGGGCATATAAGTGTCCGATTTGACCCTTTCAATTTTTTGTCTTTGCCACTACCAATGGACAGTTACATGGACTTAGAAATAACAGTGAT
TAAGTTAGATGGTACTACCCCTGTACGGTATGGACTAAGACTGAATATGGATGAAAAGTACACAGGTTTAAAAAAACAGCTGAGGGATCT
CTGTGGACTTAATTCAGAACAAATCCTACTAGCAGAAGTACATGATTCCAACATAAAGAACTTTCCTCAGGATAACCAAAAAGTACAACT
CTCAGTGAGCGGATTTTTGTGTGCATTTGAAATTCCTGTCCCTTCATCTCCAATTTCAGCTTCTAGTCCAACACAAATAGATTTCTCCTC
TTCACCATCTACAAATGGAATGTTCACCCTAACTACCAATGGGGACCTACCCAAACCAATATTCATCCCCAATGGAATGCCAAACACTGT
TGTGCCATGTGGAACTGAGAAGAACTTCACAAATGGAATGGTTAATGGTCACATGCCATCTCTTCCTGACAGCCCCTTTACAGGTTACAT
CATTGCAGTCCACCGAAAAATGATGCCCTCCAAATCCTTGGTTATGGAATATTTGGCTCATCCCAGTACACTCGGCTTGGCTGTTGGAGT
TGCTTGTGGCATGTGCCTGGGCTGGAGCCTTCGAGTATGCTTTGGGATGCTCCCCAAAAGCAAGACGAGCAAGACACACACAGATACTGA
AAGTGAAGCAAGCATCTTGGGAGACAGCGGGGAGTACAAGATGATTCTTGTGGTTCGAAATGACTTAAAGATGGGAAAAGGGAAAGTGGC
TGCCCAGTGCTCTCATGCTGCTGTTTCAGCCTACAAGCAGATTCAAAGAAGAAATCCTGAAATGCTCAAACAATGGGAATACTGTGGCCA
GCCCAAGGTGGTGGTCAAAGCTCCTGATGAAGAAACCCTGATTGCATTATTGGCCCATGCAAAAATGCTGGGACTGACTGTAAGTTTAAT
TCAAGATGCTGGACGTACTCAGATTGCACCAGGCTCTCAAACTGTCCTAGGGATTGGGCCAGGACCAGCAGACCTAATTGACAAAGTCAC
TGGTCACCTAAAACTTTACTAGGTGGACTTTGATATGACAACAACCCCTCCATCACAAGTGTTTGAAGCCTGTCAGATTCTAACAACAAA

>In-frame_ENST00000250066_ENST00000470557_TCGA-A2-A3XZ_USP6_chr17_5052062_+_PTRH2_chr17_57775339_length(amino acids)=1072AA_start in transcript=1663_stop in transcript=4881
MAGGHHSTCRGRMDMVENADSLQAQERKDILMKYDKGHRAGLPEDKGPEPVGINSSIDRFGILHETELPPVTAREAKKIRREMTRTSKWM
EMLGEWETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRE
LFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQDKEGL
CGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMNDDTVLKHLRASTKK
LTRKQGDLPPPAKREQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPWASRFSTPCPGGAVREDTYPVGTQGVPSLALA
QGGPQGSWRFLEWKSMPRLPTDLDIGGPWFPHYDFEWSCWVRAISQEDQLATCWQAEHCGEVHNKDMSWPEEMSFTANSSKIDRQKVPTE
KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDG
FQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLS
LPLPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVHDSNIKNFPQDNQKVQLSVSGFLCAFEIPVP
SSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVHRKMMPSKSLV
MEYLAHPSTLGLAVGVACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILGDSGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USP6-PTRH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USP6-PTRH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USP6-PTRH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUSP6C0410005Nodular fasciitis1ORPHANET
TgenePTRH2C4015728NEUROLOGIC, ENDOCRINE, AND PANCREATIC DISEASE, MULTISYSTEM, INFANTILE-ONSET3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgenePTRH2C0033578Prostatic Neoplasms1CTD_human
TgenePTRH2C0376358Malignant neoplasm of prostate1CTD_human