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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UTRN-WIF1 (FusionGDB2 ID:97104)

Fusion Gene Summary for UTRN-WIF1

check button Fusion gene summary
Fusion gene informationFusion gene name: UTRN-WIF1
Fusion gene ID: 97104
HgeneTgene
Gene symbol

UTRN

WIF1

Gene ID

7402

11197

Gene nameutrophinWNT inhibitory factor 1
SynonymsDMDL|DRP|DRP1WIF-1
Cytomap

6q24.2

12q14.3

Type of geneprotein-codingprotein-coding
DescriptionutrophinDRP-1dystrophin-related protein 1wnt inhibitory factor 1
Modification date2020031320200313
UniProtAcc.

Q9Y5W5

Ensembl transtripts involved in fusion geneENST00000367545, ENST00000367526, 
ENST00000480333, 		ENST00000286574, 
Fusion gene scores* DoF score34 X 28 X 11=104727 X 11 X 6=462
# samples 3714
** MAII scorelog2(37/10472*10)=-4.82286792142893
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/462*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UTRN [Title/Abstract] AND WIF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUTRN(144809970)-WIF1(65471634), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across UTRN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across WIF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-HB-A3YVUTRNchr6

144809970

+WIF1chr12

65471634

-
ChimerDB4SARCTCGA-X9-A971-01AUTRNchr6

144809970

+WIF1chr12

65471634

-
ChimerDB4SARCTCGA-HB-A3YV-01AUTRNchr6

144809970

-WIF1chr12

65471634

-


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Fusion Gene ORF analysis for UTRN-WIF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367545ENST00000286574UTRNchr6

144809970

+WIF1chr12

65471634

-
intron-3CDSENST00000367526ENST00000286574UTRNchr6

144809970

+WIF1chr12

65471634

-
intron-3CDSENST00000480333ENST00000286574UTRNchr6

144809970

+WIF1chr12

65471634

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367545UTRNchr6144809970+ENST00000286574WIF1chr1265471634-57094134049851661

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367545ENST00000286574UTRNchr6144809970+WIF1chr1265471634-0.0005144040.9994856

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Fusion Genomic Features for UTRN-WIF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UTRN-WIF1


check button Go to

FGviewer for the breakpoints of chr6:144809970-chr12:65471634

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.WIF1

Q9Y5W5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+2974150_2551378.03434.0DomainCalponin-homology (CH) 2
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+297431_1351378.03434.0DomainCalponin-homology (CH) 1
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29741_2461378.03434.0RegionNote=Actin-binding
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29741019_11211378.03434.0RepeatSpectrin 7
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29741128_12291378.03434.0RepeatSpectrin 8
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29741236_13331378.03434.0RepeatSpectrin 9
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+2974312_4161378.03434.0RepeatSpectrin 1
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+2974421_5251378.03434.0RepeatSpectrin 2
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+2974532_6361378.03434.0RepeatSpectrin 3
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+2974690_7951378.03434.0RepeatSpectrin 4
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+2974801_9011378.03434.0RepeatSpectrin 5
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+2974910_10121378.03434.0RepeatSpectrin 6
TgeneWIF1chr6:144809970chr12:65471634ENST00000286574110178_21096.0380.0DomainEGF-like 1
TgeneWIF1chr6:144809970chr12:65471634ENST00000286574110211_24296.0380.0DomainEGF-like 2
TgeneWIF1chr6:144809970chr12:65471634ENST00000286574110243_27196.0380.0DomainEGF-like 3
TgeneWIF1chr6:144809970chr12:65471634ENST00000286574110274_30696.0380.0DomainEGF-like 4
TgeneWIF1chr6:144809970chr12:65471634ENST00000286574110307_33896.0380.0DomainEGF-like 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29742812_28451378.03434.0DomainWW
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29741335_14361378.03434.0RepeatSpectrin 10
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29741438_15401378.03434.0RepeatSpectrin 11
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29741547_16481378.03434.0RepeatSpectrin 12
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29741653_17471378.03434.0RepeatSpectrin 13
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29741748_18481378.03434.0RepeatSpectrin 14
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29741849_19681378.03434.0RepeatSpectrin 15
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29741979_20801378.03434.0RepeatSpectrin 16
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29742087_21861378.03434.0RepeatSpectrin 17
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29742229_23321378.03434.0RepeatSpectrin 18
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29742349_24391378.03434.0RepeatSpectrin 19
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29742446_25551378.03434.0RepeatSpectrin 20
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29742562_26871378.03434.0RepeatSpectrin 21
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29742694_27961378.03434.0RepeatSpectrin 22
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29743064_31111378.03434.0Zinc fingerZZ-type
TgeneWIF1chr6:144809970chr12:65471634ENST0000028657411038_17796.0380.0DomainWIF


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Fusion Gene Sequence for UTRN-WIF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000367545_ENST00000286574_TCGA-HB-A3YV_UTRN_chr6_144809970_+_WIF1_chr12_65471634_length(transcript)=5709nt_BP=4134nt
ATGGCCAAGTATGGAGAACATGAAGCCAGTCCTGACAATGGGCAGAACGAATTCAGTGATATCATTAAGTCCAGATCTGATGAACACAAT
GACGTACAGAAGAAAACCTTTACCAAATGGATAAATGCTCGATTTTCAAAGAGTGGGAAACCACCCATCAATGATATGTTCACAGACCTC
AAAGATGGAAGGAAGCTATTGGATCTTCTAGAAGGCCTCACAGGAACATCACTGCCAAAGGAACGTGGTTCCACAAGGGTACATGCCTTA
AATAACGTCAACAGAGTGCTGCAGGTTTTACATCAGAACAATGTGGAATTAGTGAATATAGGGGGAACTGACATTGTGGATGGAAATCAC
AAACTGACTTTGGGGTTACTTTGGAGCATCATTTTGCACTGGCAGGTGAAAGATGTCATGAAGGATGTCATGTCGGACCTGCAGCAGACG
AACAGTGAGAAGATCCTGCTCAGCTGGGTGCGTCAGACCACCAGGCCCTACAGCCAAGTCAACGTCCTCAACTTCACCACCAGCTGGACA
GATGGACTCGCCTTTAATGCTGTCCTCCACCGACATAAACCTGATCTCTTCAGCTGGGATAAAGTTGTCAAAATGTCACCAATTGAGAGA
CTTGAACATGCCTTCAGCAAGGCTCAAACTTATTTGGGAATTGAAAAGCTGTTAGATCCTGAAGATGTTGCCGTTCAGCTTCCTGACAAG
AAATCCATAATTATGTATTTAACATCTTTGTTTGAGGTGCTACCTCAGCAAGTCACCATAGACGCCATCCGTGAGGTAGAGACACTCCCA
AGGAAATATAAAAAAGAATGTGAAGAAGAGGCAATTAATATACAGAGTACAGCGCCTGAGGAGGAGCATGAGAGTCCCCGAGCTGAAACT
CCCAGCACTGTCACTGAGGTTGACATGGATCTGGACAGCTATCAGATTGCGTTGGAGGAAGTGCTGACCTGGTTGCTTTCTGCTGAGGAC
ACTTTCCAGGAGCAGGATGATATTTCTGATGATGTTGAAGAAGTCAAAGACCAGTTTGCAACCCATGAAGCTTTTATGATGGAACTGACT
GCACACCAGAGCAGTGTGGGCAGCGTCCTGCAGGCAGGCAACCAACTGATAACACAAGGAACTCTGTCAGACGAAGAAGAATTTGAGATT
CAGGAACAGATGACCCTGCTGAATGCTAGATGGGAGGCTCTTAGGGTGGAGAGTATGGACAGACAGTCCCGGCTGCACGATGTGCTGATG
GAACTGCAGAAGAAGCAACTGCAGCAGCTCTCCGCCTGGTTAACACTCACAGAGGAGCGCATTCAGAAGATGGAAACTTGCCCCCTGGAT
GATGATGTAAAATCTCTACAAAAGCTGCTAGAAGAACATAAAAGTTTGCAAAGTGATCTTGAGGCTGAACAGGTGAAAGTAAATTCACTA
ACTCACATGGTGGTCATTGTTGATGAAAACAGTGGTGAGAGTGCTACAGCTATCCTAGAAGACCAGTTACAGAAACTTGGTGAGCGCTGG
ACAGCAGTATGCCGTTGGACTGAAGAACGCTGGAATAGGTTACAAGAAATCAATATATTGTGGCAGGAATTATTGGAAGAACAGTGCTTG
TTGAAAGCTTGGTTAACCGAAAAAGAAGAGGCTTTAAATAAAGTCCAGACAAGCAACTTCAAAGACCAAAAGGAACTAAGTGTCAGTGTT
CGACGTCTGGCTATTTTGAAGGAAGACATGGAAATGAAGCGTCAAACATTGGATCAGCTGAGTGAGATTGGCCAGGATGTGGGACAATTA
CTTGATAATTCCAAGGCATCTAAGAAGATCAACAGTGACTCAGAGGAACTGACTCAAAGATGGGATTCTTTGGTTCAGAGACTAGAAGAT
TCCTCCAACCAGGTGACTCAGGCTGTAGCAAAGCTGGGGATGTCTCAGATTCCTCAGAAGGACCTTTTGGAGACTGTTCGTGTAAGAGAA
CAAGCAATTACAAAAAAATCTAAGCAGGAACTGCCTCCTCCTCCTCCCCCAAAGAAGAGACAGATCCATGTGGATATTGAAGCTAAGAAA
AAGTTTGATGCTATAAGTGCAGAGCTGTTGAACTGGATTTTGAAATGGAAAACTGCCATTCAGACCACAGAGATAAAAGAGTATATGAAG
ATGCAAGACACTTCCGAAATGAAAAAGAAGTTGAAGGCATTAGAAAAAGAACAGAGAGAAAGAATCCCCAGAGCAGATGAATTAAACCAA
ACTGGACAAATCCTTGTGGAGCAAATGGGAAAAGAAGGCCTTCCTACTGAAGAAATAAAAAATGTTCTGGAGAAGGTTTCATCAGAATGG
AAGAATGTATCTCAACATTTGGAAGATCTAGAAAGAAAGATTCAGCTACAGGAAGATATAAATGCTTATTTCAAGCAGCTTGATGAGCTT
GAAAAGGTCATCAAGACAAAGGAGGAGTGGGTAAAACACACTTCCATTTCTGAATCTTCCCGGCAGTCCTTGCCAAGCTTGAAGGATTCC
TGTCAGCGGGAATTGACAAATCTTCTTGGCCTTCACCCCAAAATTGAAATGGCTCGTGCAAGCTGCTCGGCCCTGATGTCTCAGCCTTCT
GCCCCAGATTTTGTCCAGCGGGGCTTCGATAGCTTTCTGGGCCGCTACCAAGCTGTACAAGAGGCTGTAGAGGATCGTCAACAACATCTA
GAGAATGAACTGAAGGGCCAACCTGGACATGCATATCTGGAAACATTGAAAACACTGAAAGATGTGCTAAATGATTCAGAAAATAAGGCC
CAGGTGTCTCTGAATGTCCTTAATGATCTTGCCAAGGTGGAGAAGGCCCTGCAAGAAAAAAAGACCCTTGATGAAATCCTTGAGAATCAG
AAACCTGCATTACATAAACTTGCAGAAGAAACAAAGGCTCTGGAGAAAAATGTTCATCCTGATGTAGAAAAATTATATAAGCAAGAATTT
GATGATGTGCAAGGAAAGTGGAACAAGCTAAAGGTCTTGGTTTCCAAAGATCTACATTTGCTTGAGGAAATTGCTCTCACACTCAGAGCT
TTTGAGGCCGATTCAACAGTCATTGAGAAGTGGATGGATGGCGTGAAAGACTTCTTAATGAAACAGCAGGCTGCCCAAGGAGACGACGCA
GGTCTACAGAGGCAGTTAGACCAGTGCTCTGCATTTGTTAATGAAATAGAAACAATTGAATCATCTCTGAAAAACATGAAGGAAATAGAG
ACTAATCTTCGAAGTGGTCCAGTTGCTGGAATAAAAACTTGGGTGCAGACAAGACTAGGTGACTACCAAACTCAACTGGAGAAACTTAGC
AAGGAGATCGCTACTCAAAAAAGTAGGTTGTCTGAAAGTCAAGAAAAAGCTGCGAACCTGAAGAAAGACTTGGCAGAGATGCAGGAATGG
ATGACCCAGGCCGAGGAAGAATATTTGGAGCGGGATTTTGAGTACAAGTCACCAGAAGAGCTTGAGAGTGCTGTGGAAGAGATGAAGAGG
GCAAAAGAGGATGTGTTGCAGAAGGAGGTGAGAGTGAAGATTCTCAAGGACAACATCAAGTTATTAGCTGCCAAGGTGCCCTCTGGTGGC
CAGGAGTTGACGTCTGAGCTGAATGTTGTGCTGGAGAATTACCAACTTCTTTGTAATAGAATTCGAGGAAAGTGCCACACGCTAGAGGAG
GTCTGGTCTTGTTGGATTGAACTGCTTCACTATTTGGATCTTGAAACTACCTGGTTAAACACTTTGGAAGAGCGGATGAAGAGCACAGAG
GTCCTGCCTGAGAAGACGGATGCTGTCAACGAAGCCCTGGAGTCTCTGGAATCTGTTCTGCGCCACCCGGCAGATAATCGCACCCAGATT
CGAGAGCTTGGCCAGACTCTGATTGATGGGGGGATCCTGGATGATATAATCAGTGAGAAACTGGAGGCTTTCAACAGCCGATATGAAGAT
CTAAGTCACCTGGCAGAGAGCAAGCAGATTTCTTTGGAAAAGCAACTCCAGGTGCTGCGGGAAACTGACCAGATGCTTCAAGTCTTGCAA
GAGAGCTTGGGGGAGCTGGACAAACAGCTCACCACATACCTGACTGACAGGATAGATGCTTTCCAAGTTCCACAGGAAGCTCAGGCAGAA
TACTTCTATGAATTCCTGTCCTTGCGCTCCCTGGATAAAGGCATCATGGCAGATCCAACCGTCAATGTCCCTCTGCTGGGAACAGTGCCT
CACAAGGCATCAGTTGTTCAAGTTGGTTTCCCATGTCTTGGAAAACAGGATGGGGTGGCAGCATTTGAAGTGGATGTGATTGTTATGAAT
TCTGAAGGCAACACCATTCTCCAAACACCTCAAAATGCTATCTTCTTTAAAACATGTCAACAAGCTGAGTGCCCAGGCGGGTGCCGAAAT
GGAGGCTTTTGTAATGAAAGACGCATCTGCGAGTGTCCTGATGGGTTCCACGGACCTCACTGTGAGAAAGCCCTTTGTACCCCACGATGT
ATGAATGGTGGACTTTGTGTGACTCCTGGTTTCTGCATCTGCCCACCTGGATTCTATGGAGTGAACTGTGACAAAGCAAACTGCTCAACC
ACCTGCTTTAATGGAGGGACCTGTTTCTACCCTGGAAAATGTATTTGCCCTCCAGGACTAGAGGGAGAGCAGTGTGAAATCAGCAAATGC
CCACAACCCTGTCGAAATGGAGGTAAATGCATTGGTAAAAGCAAATGTAAGTGTTCCAAAGGTTACCAGGGAGACCTCTGTTCAAAGCCT
GTCTGCGAGCCTGGCTGTGGTGCACATGGAACCTGCCATGAACCCAACAAATGCCAATGTCAAGAAGGTTGGCATGGAAGACACTGCAAT
AAAAGGTACGAAGCCAGCCTCATACATGCCCTGAGGCCAGCAGGCGCCCAGCTCAGGCAGCACACGCCTTCACTTAAAAAGGCCGAGGAG
CGGCGGGATCCACCTGAATCCAATTACATCTGGTGAACTCCGACATCTGAAACGTTTTAAGTTACACCAAGTTCATAGCCTTTGTTAACC
TTTCATGTGTTGAATGTTCAAATAATGTTCATTACACTTAAGAATACTGGCCTGAATTTTATTAGCTTCATTATAAATCACTGAGCTGAT
ATTTACTCTTCCTTTTAAGTTTTCTAAGTACGTCTGTAGCATGATGGTATAGATTTTCTTGTTTCAGTGCTTTGGGACAGATTTTATATT
ATGTCAATTGATCAGGTTAAAATTTTCAGTGTGTAGTTGGCAGATATTTTCAAAATTACAATGCATTTATGGTGTCTGGGGGCAGGGGAA
CATCAGAAAGGTTAAATTGGGCAAAAATGCGTAAGTCACAAGAATTTGGATGGTGCAGTTAATGTTGAAGTTACAGCATTTCAGATTTTA
TTGTCAGATATTTAGATGTTTGTTACATTTTTAAAAATTGCTCTTAATTTTTAAACTCTCAATACAATATATTTTGACCTTACCATTATT
CCAGAGATTCAGTATTAAAAAAAAAAAAATTACACTGTGGTAGTGGCATTTAAACAATATAATATATTCTAAACACAATGAAATAGGGAA
TATAATGTATGAACTTTTTGCATTGGCTTGAAGCAATATAATATATTGTAAACAAAACACAGCTCTTACCTAATAAACATTTTATACTGT

>In-frame_ENST00000367545_ENST00000286574_TCGA-HB-A3YV_UTRN_chr6_144809970_+_WIF1_chr12_65471634_length(amino acids)=1661AA_start in transcript=0_stop in transcript=4985
MAKYGEHEASPDNGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKERGSTRVHAL
NNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWT
DGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLP
RKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELT
AHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLD
DDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCL
LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLED
SSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMK
MQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDEL
EKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHL
ENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEF
DDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIE
TNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKR
AKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTE
VLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQ
ESLGELDKQLTTYLTDRIDAFQVPQEAQAEYFYEFLSLRSLDKGIMADPTVNVPLLGTVPHKASVVQVGFPCLGKQDGVAAFEVDVIVMN
SEGNTILQTPQNAIFFKTCQQAECPGGCRNGGFCNERRICECPDGFHGPHCEKALCTPRCMNGGLCVTPGFCICPPGFYGVNCDKANCST
TCFNGGTCFYPGKCICPPGLEGEQCEISKCPQPCRNGGKCIGKSKCKCSKGYQGDLCSKPVCEPGCGAHGTCHEPNKCQCQEGWHGRHCN

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Fusion Gene PPI Analysis for UTRN-WIF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+2974268_9051378.03434.0SYNM


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29741336_17681378.03434.0SYNM
HgeneUTRNchr6:144809970chr12:65471634ENST00000367545+29742798_31651378.03434.0SYNM


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UTRN-WIF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UTRN-WIF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWIF1C0009402Colorectal Carcinoma1CTD_human
TgeneWIF1C0009404Colorectal Neoplasms1CTD_human
TgeneWIF1C0014859Esophageal Neoplasms1CTD_human
TgeneWIF1C0024623Malignant neoplasm of stomach1CTD_human
TgeneWIF1C0027439Nasopharyngeal Neoplasms1CTD_human
TgeneWIF1C0038356Stomach Neoplasms1CTD_human
TgeneWIF1C0238301Cancer of Nasopharynx1CTD_human
TgeneWIF1C0546837Malignant neoplasm of esophagus1CTD_human
TgeneWIF1C1708349Hereditary Diffuse Gastric Cancer1CTD_human