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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UVRAG-BLMH (FusionGDB2 ID:97115)

Fusion Gene Summary for UVRAG-BLMH

check button Fusion gene summary
Fusion gene informationFusion gene name: UVRAG-BLMH
Fusion gene ID: 97115
HgeneTgene
Gene symbol

UVRAG

BLMH

Gene ID

7405

642

Gene nameUV radiation resistance associatedbleomycin hydrolase
SynonymsDHTX|VPS38|p63BH|BMH
Cytomap

11q13.5

17q11.2

Type of geneprotein-codingprotein-coding
DescriptionUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxybleomycin hydrolaseBLM hydrolase
Modification date2020031320200313
UniProtAcc.

Q13867

Ensembl transtripts involved in fusion geneENST00000356136, ENST00000528420, 
ENST00000533454, ENST00000531818, 
ENST00000532130, ENST00000539288, 
ENST00000525872, ENST00000538870, 
ENST00000261714, ENST00000394819, 
ENST00000582669, 
Fusion gene scores* DoF score41 X 18 X 15=110709 X 10 X 8=720
# samples 4911
** MAII scorelog2(49/11070*10)=-4.49772966266634
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/720*10)=-2.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UVRAG [Title/Abstract] AND BLMH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUVRAG(75594395)-BLMH(28593902), # samples:1
UVRAG(75599946)-BLMH(28601165), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

HgeneUVRAG

GO:0097352

autophagosome maturation

28306502

HgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840


check buttonFusion gene breakpoints across UVRAG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BLMH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-5B-A90C-01AUVRAGchr11

75594395

+BLMHchr17

28593902

+
ChimerDB4UCECTCGA-5B-A90C-01AUVRAGchr11

75599946

+BLMHchr17

28601165

+


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Fusion Gene ORF analysis for UVRAG-BLMH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000356136ENST00000261714UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000356136ENST00000394819UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000356136ENST00000582669UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000528420ENST00000261714UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000528420ENST00000394819UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000528420ENST00000582669UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000533454ENST00000261714UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000533454ENST00000394819UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000533454ENST00000582669UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000531818ENST00000261714UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000531818ENST00000394819UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000531818ENST00000582669UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000532130ENST00000261714UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000532130ENST00000394819UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000532130ENST00000582669UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000539288ENST00000261714UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000539288ENST00000394819UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000539288ENST00000582669UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000525872ENST00000261714UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000525872ENST00000394819UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000525872ENST00000582669UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000538870ENST00000261714UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000538870ENST00000394819UVRAGchr11

75594395

+BLMHchr17

28593902

+
intron-intronENST00000538870ENST00000582669UVRAGchr11

75594395

+BLMHchr17

28593902

+
In-frameENST00000356136ENST00000261714UVRAGchr11

75599946

+BLMHchr17

28601165

+
In-frameENST00000356136ENST00000394819UVRAGchr11

75599946

+BLMHchr17

28601165

+
5CDS-5UTRENST00000356136ENST00000582669UVRAGchr11

75599946

+BLMHchr17

28601165

+
In-frameENST00000528420ENST00000261714UVRAGchr11

75599946

+BLMHchr17

28601165

+
In-frameENST00000528420ENST00000394819UVRAGchr11

75599946

+BLMHchr17

28601165

+
5CDS-5UTRENST00000528420ENST00000582669UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-3CDSENST00000533454ENST00000261714UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-3CDSENST00000533454ENST00000394819UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-5UTRENST00000533454ENST00000582669UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-3CDSENST00000531818ENST00000261714UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-3CDSENST00000531818ENST00000394819UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-5UTRENST00000531818ENST00000582669UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-3CDSENST00000532130ENST00000261714UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-3CDSENST00000532130ENST00000394819UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-5UTRENST00000532130ENST00000582669UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-3CDSENST00000539288ENST00000261714UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-3CDSENST00000539288ENST00000394819UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-5UTRENST00000539288ENST00000582669UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-3CDSENST00000525872ENST00000261714UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-3CDSENST00000525872ENST00000394819UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-5UTRENST00000525872ENST00000582669UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-3CDSENST00000538870ENST00000261714UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-3CDSENST00000538870ENST00000394819UVRAGchr11

75599946

+BLMHchr17

28601165

+
intron-5UTRENST00000538870ENST00000582669UVRAGchr11

75599946

+BLMHchr17

28601165

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356136UVRAGchr1175599946+ENST00000261714BLMHchr1728601165+2238748765148205
ENST00000356136UVRAGchr1175599946+ENST00000394819BLMHchr1728601165+1606748765148205
ENST00000528420UVRAGchr1175599946+ENST00000261714BLMHchr1728601165+197948996503135
ENST00000528420UVRAGchr1175599946+ENST00000394819BLMHchr1728601165+134748950687139

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356136ENST00000261714UVRAGchr1175599946+BLMHchr1728601165+0.0062368870.99376315
ENST00000356136ENST00000394819UVRAGchr1175599946+BLMHchr1728601165+0.0052315310.9947685
ENST00000528420ENST00000261714UVRAGchr1175599946+BLMHchr1728601165+0.404247520.5957525
ENST00000528420ENST00000394819UVRAGchr1175599946+BLMHchr1728601165+0.195684730.80431527

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Fusion Genomic Features for UVRAG-BLMH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UVRAG-BLMH


check button Go to

FGviewer for the breakpoints of chr11:75599946-chr17:28601165

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BLMH

Q13867

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUVRAGchr11:75599946chr17:28601165ENST00000356136+51523_149169.0700.0DomainC2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUVRAGchr11:75599946chr17:28601165ENST00000356136+515224_305169.0700.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for UVRAG-BLMH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000356136_ENST00000261714_TCGA-5B-A90C-01A_UVRAG_chr11_75599946_+_BLMH_chr17_28601165_length(transcript)=2238nt_BP=748nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGCG
GCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTTACACTTCACTT
GTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGTCTCGATTTTGG
AATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAGCTGTTGATTGA
ATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGG
ATACTATGGTGCTCCATTTGAACATAAGGTTACCTGTGCATGACAGATGAGTGGTTCTCTGAGTATGTCTACGAAGTGGTGGTGGACAGG
AAGCATGTCCCTGAAGAGGTGCTAGCTGTGTTAGAGCAGGAACCCATTATCCTGCCAGCATGGGACCCCATGGGAGCTTTGGCTGAGTGA
TACTGCCCTCCAGCTCTTTCCTCCTTCCATGGAACCTGACGTAGCTGCAAAGGACAGATCCAGGGACTGAAGCCAAAGTTATGCAAGGGA
CTGTGTGTTGCCACAGGACACAGTCAGATTTCCAGTCTCCACCAGGAACCTCTTCAGAAAGTGTGCTTTATGCTGAAACAGAATACTGTT
AAAGGAAAAAAAAGAGGGGGGAAGATCAGGTCATACTATCTACTCTCCTCATCTCTAACAGCTCAGGATCTCTTAGCATTTTAATTAGAT
GTAATTGTTTGTCTTTAACTGTCAAAAAGTTTGGTTCTGTGTCTGTGTTTTAATAAGACGAGAGGACGAGCGATTGAGGTGTATGGAGAG
AAAACAGACCTAATGCTCCTTGTTCCTAGAGTAGAGTGGAGGGAGGGTGGCCTAAGAGTTGAGCTCTCGGAACTGCATGCTGCTGGACAG
TATCACTGTCTTTCCTAGATGGCAGTCACTGAATTCCATTTTTTCAAGGTAATTTCTTGTGCCTCTAATAGCCCAAGAATGGGAGGTTGA
TCAGATCTGACATGATTCCTTCCTGTTCTGAACTGTGGGGTGTGCACATCTCTGCTTGAGTCAGGTTTGAGTAGAGGCTTAGAGACAGTT
GGGTGAGAACAACCAAAATCTTATCATGGTCTCAGTCATAATCATTAGGGGGAACTCTAGCCAAATGGTTTAACTTCTGCCTGTGGAACT
GGGGATTGGGTGGGCAGGAAAAGGTGATATCCATTCTTTCTGATAACTAGATGGTGCTGAGAAGCTTTTGAATAAAAACTTTGCTAAATG
AGAATAAGATGATCAGGATGGTGCTTTCACAAAATGGAGAGTGGAGAATTCATGGGGTGAAGACCATGGCCACAAAGCTATGACCATGAG
TTAGTGTTTGGTGTCTCCTTGAAGAACATGAATAAAGCGGAGAGGCTGACTTTTGGTGAGTCACTTATGACCCACGCCATGACCTTCACT
GCTGTCTCAGAGAAGGCTGTGTGGTTTGGCTGTGATGTTGGAAAACACTTCAATAGCAAGCTGGGCCTCAGTGACATGAATCTATTTGTT
TAGTGAATGACCCTAGGCCCCAGCACAAGTACAACAAACTTTACACAGTGGAATACTTAAGCAATATGGTTGGAGGGAGAAAAACTCTAT
ACAACAACCAGCCCATTGACTTCCTGAAAAAGATGGTTGCTGCCTCCATCAAAGATGGAGAGCTGGGAATATCGAGACAAAGATAAAAAT

>In-frame_ENST00000356136_ENST00000261714_TCGA-5B-A90C-01A_UVRAG_chr11_75599946_+_BLMH_chr17_28601165_length(amino acids)=205AA_start in transcript=765_stop in transcript=148
MSCTGNLMFKWSTIVSIIQPKNYFILVSGMNLLTQVFQPIQTDFPFNQQLVDVLLSTPYLHHETRHRCIKTVWHNSKIETSPRGIQGILN
HFTSIKFFIYLFSTTQVKCKVGIKELMAISINNVPGSNVPKMSKTPLLRRQLHMQGPRGRTGRQSSGRARGWLGDGAPDRRGGAHLDPGA

--------------------------------------------------------------
>In-frame_ENST00000356136_ENST00000394819_TCGA-5B-A90C-01A_UVRAG_chr11_75599946_+_BLMH_chr17_28601165_length(transcript)=1606nt_BP=748nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGCG
GCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTTACACTTCACTT
GTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGTCTCGATTTTGG
AATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAGCTGTTGATTGA
ATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGG
ATACTATGGTGCTCCATTTGAACATAAGGTTACCTGTGCATGACAGATGAGTGGTTCTCTGAGTATGTCTACGAAGTGGTGGTGGACAGG
AAGCATGTCCCTGAAGAGGTGCTAGCTGTGTTAGAGCAGGAACCCATTATCCTGCCAGCATGGGACCCCATGGGAGCTTTGGCTGAGTGA
TACTGCCCTCCAGCTCTTTCCTCCTTCCATGGAACCTGACGTAGCTGCAAAGGACAGATCCAGGGACTGAAGCCAAAGTTATGCAAGGGA
CTGTGTGTTGCCACAGGACACAGTCAGATTTCCAGTCTCCACCAGGAACCTCTTCAGAAAGTGTGCTTTATGCTGAAACAGAATACTGTT
AAAGGGATGATCAGGATGGTGCTTTCACAAAATGGAGAGTGGAGAATTCATGGGGTGAAGACCATGGCCACAAAGCTATGACCATGAGTT
AGTGTTTGGTGTCTCCTTGAAGAACATGAATAAAGCGGAGAGGCTGACTTTTGGTGAGTCACTTATGACCCACGCCATGACCTTCACTGC
TGTCTCAGAGAAGGCTGTGTGGTTTGGCTGTGATGTTGGAAAACACTTCAATAGCAAGCTGGGCCTCAGTGACATGAATCTATTTGTTTA
GTGAATGACCCTAGGCCCCAGCACAAGTACAACAAACTTTACACAGTGGAATACTTAAGCAATATGGTTGGAGGGAGAAAAACTCTATAC
AACAACCAGCCCATTGACTTCCTGAAAAAGATGGTTGCTGCCTCCATCAAAGATGGAGAGCTGGGAATATCGAGACAAAGATAAAAATTA

>In-frame_ENST00000356136_ENST00000394819_TCGA-5B-A90C-01A_UVRAG_chr11_75599946_+_BLMH_chr17_28601165_length(amino acids)=205AA_start in transcript=765_stop in transcript=148
MSCTGNLMFKWSTIVSIIQPKNYFILVSGMNLLTQVFQPIQTDFPFNQQLVDVLLSTPYLHHETRHRCIKTVWHNSKIETSPRGIQGILN
HFTSIKFFIYLFSTTQVKCKVGIKELMAISINNVPGSNVPKMSKTPLLRRQLHMQGPRGRTGRQSSGRARGWLGDGAPDRRGGAHLDPGA

--------------------------------------------------------------
>In-frame_ENST00000528420_ENST00000261714_TCGA-5B-A90C-01A_UVRAG_chr11_75599946_+_BLMH_chr17_28601165_length(transcript)=1979nt_BP=489nt
AGTGCTCAGCTCCCTTGCCATGCGATACCCTGCAAGTCCTCACCAGCAAAAAGGCTCTCACCAGAGGCTGCCCCTCGGCCTGTGTTATCA
GATTTTTTGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTT
ACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGT
CTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAG
CTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGG
CTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGTTACCTGTGCATGACAGATGAGTGGTTCTCTGAGTATGTCTACGAAGTGG
TGGTGGACAGGAAGCATGTCCCTGAAGAGGTGCTAGCTGTGTTAGAGCAGGAACCCATTATCCTGCCAGCATGGGACCCCATGGGAGCTT
TGGCTGAGTGATACTGCCCTCCAGCTCTTTCCTCCTTCCATGGAACCTGACGTAGCTGCAAAGGACAGATCCAGGGACTGAAGCCAAAGT
TATGCAAGGGACTGTGTGTTGCCACAGGACACAGTCAGATTTCCAGTCTCCACCAGGAACCTCTTCAGAAAGTGTGCTTTATGCTGAAAC
AGAATACTGTTAAAGGAAAAAAAAGAGGGGGGAAGATCAGGTCATACTATCTACTCTCCTCATCTCTAACAGCTCAGGATCTCTTAGCAT
TTTAATTAGATGTAATTGTTTGTCTTTAACTGTCAAAAAGTTTGGTTCTGTGTCTGTGTTTTAATAAGACGAGAGGACGAGCGATTGAGG
TGTATGGAGAGAAAACAGACCTAATGCTCCTTGTTCCTAGAGTAGAGTGGAGGGAGGGTGGCCTAAGAGTTGAGCTCTCGGAACTGCATG
CTGCTGGACAGTATCACTGTCTTTCCTAGATGGCAGTCACTGAATTCCATTTTTTCAAGGTAATTTCTTGTGCCTCTAATAGCCCAAGAA
TGGGAGGTTGATCAGATCTGACATGATTCCTTCCTGTTCTGAACTGTGGGGTGTGCACATCTCTGCTTGAGTCAGGTTTGAGTAGAGGCT
TAGAGACAGTTGGGTGAGAACAACCAAAATCTTATCATGGTCTCAGTCATAATCATTAGGGGGAACTCTAGCCAAATGGTTTAACTTCTG
CCTGTGGAACTGGGGATTGGGTGGGCAGGAAAAGGTGATATCCATTCTTTCTGATAACTAGATGGTGCTGAGAAGCTTTTGAATAAAAAC
TTTGCTAAATGAGAATAAGATGATCAGGATGGTGCTTTCACAAAATGGAGAGTGGAGAATTCATGGGGTGAAGACCATGGCCACAAAGCT
ATGACCATGAGTTAGTGTTTGGTGTCTCCTTGAAGAACATGAATAAAGCGGAGAGGCTGACTTTTGGTGAGTCACTTATGACCCACGCCA
TGACCTTCACTGCTGTCTCAGAGAAGGCTGTGTGGTTTGGCTGTGATGTTGGAAAACACTTCAATAGCAAGCTGGGCCTCAGTGACATGA
ATCTATTTGTTTAGTGAATGACCCTAGGCCCCAGCACAAGTACAACAAACTTTACACAGTGGAATACTTAAGCAATATGGTTGGAGGGAG
AAAAACTCTATACAACAACCAGCCCATTGACTTCCTGAAAAAGATGGTTGCTGCCTCCATCAAAGATGGAGAGCTGGGAATATCGAGACA

>In-frame_ENST00000528420_ENST00000261714_TCGA-5B-A90C-01A_UVRAG_chr11_75599946_+_BLMH_chr17_28601165_length(amino acids)=135AA_start in transcript=96_stop in transcript=503
MRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLL

--------------------------------------------------------------
>In-frame_ENST00000528420_ENST00000394819_TCGA-5B-A90C-01A_UVRAG_chr11_75599946_+_BLMH_chr17_28601165_length(transcript)=1347nt_BP=489nt
AGTGCTCAGCTCCCTTGCCATGCGATACCCTGCAAGTCCTCACCAGCAAAAAGGCTCTCACCAGAGGCTGCCCCTCGGCCTGTGTTATCA
GATTTTTTGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTT
ACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGT
CTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAG
CTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGG
CTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGTTACCTGTGCATGACAGATGAGTGGTTCTCTGAGTATGTCTACGAAGTGG
TGGTGGACAGGAAGCATGTCCCTGAAGAGGTGCTAGCTGTGTTAGAGCAGGAACCCATTATCCTGCCAGCATGGGACCCCATGGGAGCTT
TGGCTGAGTGATACTGCCCTCCAGCTCTTTCCTCCTTCCATGGAACCTGACGTAGCTGCAAAGGACAGATCCAGGGACTGAAGCCAAAGT
TATGCAAGGGACTGTGTGTTGCCACAGGACACAGTCAGATTTCCAGTCTCCACCAGGAACCTCTTCAGAAAGTGTGCTTTATGCTGAAAC
AGAATACTGTTAAAGGGATGATCAGGATGGTGCTTTCACAAAATGGAGAGTGGAGAATTCATGGGGTGAAGACCATGGCCACAAAGCTAT
GACCATGAGTTAGTGTTTGGTGTCTCCTTGAAGAACATGAATAAAGCGGAGAGGCTGACTTTTGGTGAGTCACTTATGACCCACGCCATG
ACCTTCACTGCTGTCTCAGAGAAGGCTGTGTGGTTTGGCTGTGATGTTGGAAAACACTTCAATAGCAAGCTGGGCCTCAGTGACATGAAT
CTATTTGTTTAGTGAATGACCCTAGGCCCCAGCACAAGTACAACAAACTTTACACAGTGGAATACTTAAGCAATATGGTTGGAGGGAGAA
AAACTCTATACAACAACCAGCCCATTGACTTCCTGAAAAAGATGGTTGCTGCCTCCATCAAAGATGGAGAGCTGGGAATATCGAGACAAA

>In-frame_ENST00000528420_ENST00000394819_TCGA-5B-A90C-01A_UVRAG_chr11_75599946_+_BLMH_chr17_28601165_length(amino acids)=139AA_start in transcript=506_stop in transcript=87
MSCTGNLMFKWSTIVSIIQPKNYFILVSGMNLLTQVFQPIQTDFPFNQQLVDVLLSTPYLHHETRHRCIKTVWHNSKIETSPRGIQGILN

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Fusion Gene PPI Analysis for UVRAG-BLMH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UVRAG-BLMH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UVRAG-BLMH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource