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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UVRAG-INTS4 (FusionGDB2 ID:97126)

Fusion Gene Summary for UVRAG-INTS4

check button Fusion gene summary
Fusion gene informationFusion gene name: UVRAG-INTS4
Fusion gene ID: 97126
HgeneTgene
Gene symbol

UVRAG

INTS4

Gene ID

7405

92105

Gene nameUV radiation resistance associatedintegrator complex subunit 4
SynonymsDHTX|VPS38|p63INT4|MST093
Cytomap

11q13.5

11q14.1

Type of geneprotein-codingprotein-coding
DescriptionUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxyintegrator complex subunit 4MSTP093
Modification date2020031320200313
UniProtAcc.

Q96HW7

Ensembl transtripts involved in fusion geneENST00000356136, ENST00000528420, 
ENST00000533454, ENST00000531818, 
ENST00000532130, ENST00000539288, 
ENST00000525872, ENST00000538870, 
ENST00000534064, ENST00000535943, 
ENST00000525931, ENST00000529807, 
ENST00000527522, 
Fusion gene scores* DoF score41 X 18 X 15=1107013 X 9 X 8=936
# samples 4916
** MAII scorelog2(49/11070*10)=-4.49772966266634
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/936*10)=-2.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UVRAG [Title/Abstract] AND INTS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUVRAG(75623083)-INTS4(77618856), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

HgeneUVRAG

GO:0097352

autophagosome maturation

28306502

HgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840

TgeneINTS4

GO:0016180

snRNA processing

16239144


check buttonFusion gene breakpoints across UVRAG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across INTS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SJ-01AUVRAGchr11

75623083

+INTS4chr11

77618856

-
ChimerDB4BRCATCGA-A1-A0SJUVRAGchr11

75623083

+INTS4chr11

77618856

-
ChimerDB4BRCATCGA-A1-A0SJ-01AUVRAGchr11

75623083

+INTS4chr11

77618856

-
ChimerDB4BRCATCGA-A1-A0SJ-01AUVRAGchr11

75623083

-INTS4chr11

77618856

-


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Fusion Gene ORF analysis for UVRAG-INTS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356136ENST00000534064UVRAGchr11

75623083

+INTS4chr11

77618856

-
In-frameENST00000356136ENST00000535943UVRAGchr11

75623083

+INTS4chr11

77618856

-
5CDS-intronENST00000356136ENST00000525931UVRAGchr11

75623083

+INTS4chr11

77618856

-
5CDS-intronENST00000356136ENST00000529807UVRAGchr11

75623083

+INTS4chr11

77618856

-
5CDS-intronENST00000356136ENST00000527522UVRAGchr11

75623083

+INTS4chr11

77618856

-
In-frameENST00000528420ENST00000534064UVRAGchr11

75623083

+INTS4chr11

77618856

-
In-frameENST00000528420ENST00000535943UVRAGchr11

75623083

+INTS4chr11

77618856

-
5CDS-intronENST00000528420ENST00000525931UVRAGchr11

75623083

+INTS4chr11

77618856

-
5CDS-intronENST00000528420ENST00000529807UVRAGchr11

75623083

+INTS4chr11

77618856

-
5CDS-intronENST00000528420ENST00000527522UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-3CDSENST00000533454ENST00000534064UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-3CDSENST00000533454ENST00000535943UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000533454ENST00000525931UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000533454ENST00000529807UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000533454ENST00000527522UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-3CDSENST00000531818ENST00000534064UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-3CDSENST00000531818ENST00000535943UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000531818ENST00000525931UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000531818ENST00000529807UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000531818ENST00000527522UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-3CDSENST00000532130ENST00000534064UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-3CDSENST00000532130ENST00000535943UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000532130ENST00000525931UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000532130ENST00000529807UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000532130ENST00000527522UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-3CDSENST00000539288ENST00000534064UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-3CDSENST00000539288ENST00000535943UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000539288ENST00000525931UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000539288ENST00000529807UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000539288ENST00000527522UVRAGchr11

75623083

+INTS4chr11

77618856

-
3UTR-3CDSENST00000525872ENST00000534064UVRAGchr11

75623083

+INTS4chr11

77618856

-
3UTR-3CDSENST00000525872ENST00000535943UVRAGchr11

75623083

+INTS4chr11

77618856

-
3UTR-intronENST00000525872ENST00000525931UVRAGchr11

75623083

+INTS4chr11

77618856

-
3UTR-intronENST00000525872ENST00000529807UVRAGchr11

75623083

+INTS4chr11

77618856

-
3UTR-intronENST00000525872ENST00000527522UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-3CDSENST00000538870ENST00000534064UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-3CDSENST00000538870ENST00000535943UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000538870ENST00000525931UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000538870ENST00000529807UVRAGchr11

75623083

+INTS4chr11

77618856

-
intron-intronENST00000538870ENST00000527522UVRAGchr11

75623083

+INTS4chr11

77618856

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356136UVRAGchr1175623083+ENST00000534064INTS4chr1177618856-20338341631803546
ENST00000356136UVRAGchr1175623083+ENST00000535943INTS4chr1177618856-20318341631803546
ENST00000528420UVRAGchr1175623083+ENST00000534064INTS4chr1177618856-1774575961544482
ENST00000528420UVRAGchr1175623083+ENST00000535943INTS4chr1177618856-1772575961544482

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356136ENST00000534064UVRAGchr1175623083+INTS4chr1177618856-0.0022994170.99770063
ENST00000356136ENST00000535943UVRAGchr1175623083+INTS4chr1177618856-0.0022936580.9977063
ENST00000528420ENST00000534064UVRAGchr1175623083+INTS4chr1177618856-0.0019066390.9980933
ENST00000528420ENST00000535943UVRAGchr1175623083+INTS4chr1177618856-0.0019078030.99809223

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Fusion Genomic Features for UVRAG-INTS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UVRAG-INTS4


check button Go to

FGviewer for the breakpoints of chr11:75623083-chr11:77618856

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.INTS4

Q96HW7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUVRAGchr11:75623083chr11:77618856ENST00000356136+61523_149197.66666666666666700.0DomainC2
TgeneINTS4chr11:75623083chr11:77618856ENST00000529807012145_1830506.0RepeatNote=HEAT 2
TgeneINTS4chr11:75623083chr11:77618856ENST00000529807012190_2280506.0RepeatNote=HEAT 3
TgeneINTS4chr11:75623083chr11:77618856ENST00000529807012229_2630506.0RepeatNote=HEAT 4
TgeneINTS4chr11:75623083chr11:77618856ENST00000529807012277_3130506.0RepeatNote=HEAT 5
TgeneINTS4chr11:75623083chr11:77618856ENST00000529807012369_4050506.0RepeatNote=HEAT 6
TgeneINTS4chr11:75623083chr11:77618856ENST00000529807012406_4440506.0RepeatNote=HEAT 7
TgeneINTS4chr11:75623083chr11:77618856ENST00000529807012446_4840506.0RepeatNote=HEAT 8
TgeneINTS4chr11:75623083chr11:77618856ENST0000052980701266_1050506.0RepeatNote=HEAT 1
TgeneINTS4chr11:75623083chr11:77618856ENST0000053594309145_18315.666666666666666339.0RepeatNote=HEAT 2
TgeneINTS4chr11:75623083chr11:77618856ENST0000053594309190_22815.666666666666666339.0RepeatNote=HEAT 3
TgeneINTS4chr11:75623083chr11:77618856ENST0000053594309229_26315.666666666666666339.0RepeatNote=HEAT 4
TgeneINTS4chr11:75623083chr11:77618856ENST0000053594309277_31315.666666666666666339.0RepeatNote=HEAT 5
TgeneINTS4chr11:75623083chr11:77618856ENST0000053594309369_40515.666666666666666339.0RepeatNote=HEAT 6
TgeneINTS4chr11:75623083chr11:77618856ENST0000053594309406_44415.666666666666666339.0RepeatNote=HEAT 7
TgeneINTS4chr11:75623083chr11:77618856ENST0000053594309446_48415.666666666666666339.0RepeatNote=HEAT 8
TgeneINTS4chr11:75623083chr11:77618856ENST000005359430966_10515.666666666666666339.0RepeatNote=HEAT 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUVRAGchr11:75623083chr11:77618856ENST00000356136+615224_305197.66666666666666700.0Coiled coilOntology_term=ECO:0000255
TgeneINTS4chr11:75623083chr11:77618856ENST000005340641423145_183640.6666666666666964.0RepeatNote=HEAT 2
TgeneINTS4chr11:75623083chr11:77618856ENST000005340641423190_228640.6666666666666964.0RepeatNote=HEAT 3
TgeneINTS4chr11:75623083chr11:77618856ENST000005340641423229_263640.6666666666666964.0RepeatNote=HEAT 4
TgeneINTS4chr11:75623083chr11:77618856ENST000005340641423277_313640.6666666666666964.0RepeatNote=HEAT 5
TgeneINTS4chr11:75623083chr11:77618856ENST000005340641423369_405640.6666666666666964.0RepeatNote=HEAT 6
TgeneINTS4chr11:75623083chr11:77618856ENST000005340641423406_444640.6666666666666964.0RepeatNote=HEAT 7
TgeneINTS4chr11:75623083chr11:77618856ENST000005340641423446_484640.6666666666666964.0RepeatNote=HEAT 8
TgeneINTS4chr11:75623083chr11:77618856ENST00000534064142366_105640.6666666666666964.0RepeatNote=HEAT 1


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Fusion Gene Sequence for UVRAG-INTS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000356136_ENST00000534064_TCGA-A1-A0SJ-01A_UVRAG_chr11_75623083_+_INTS4_chr11_77618856_length(transcript)=2033nt_BP=834nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGCG
GCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTTACACTTCACTT
GTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGTCTCGATTTTGG
AATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAGCTGTTGATTGA
ATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGG
ATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTC
TTACGATGTCTTCTCTTTGCTACGGGATCTGCAAAGACTTGGAGAACTTCAATCTGAATTGGCAGGAGTAGCTGATTTCTCTGCCACCTA
TCTTCGCTGTCAACTACTTCTCATCAAGGCCTTGCAGGAAAAGTTGTGGAATGTAGCTGCCCCTTTGTATTTGAAGCAGAGTGATTTGGC
CTCAGCAGCAGCGAAACAGATTATGGAAGAGACCTACAAAATGGAATTCATGTACAGTGGTGTGGAGAATAAGCAGGTGGTGATTATACA
TCACATGAGGCTGCAGGCCAAAGCTTTGCAACTTATAGTAACAGCACGAACTACACGAGGACTTGACCCCTTATTTGGGATGTGTGAAAA
ATTTTTACAGGAAGTAGACTTTTTTCAGAGGTATTTCATCGCTGATTTGCCCCACTTGCAGGACAGCTTTGTGGACAAACTCCTTGACCT
TATGCCCCGACTCATGACATCCAAACCTGCAGAAGTGGTCAAAATTCTACAGACCATGCTGCGACAGAGTGCCTTTCTGCATCTCCCGCT
TCCAGAGCAGATCCACAAAGCCTCAGCCACCATCATCGAGCCAGCGGGCGAGTCAGACAACCCTTTGCGGTTTACCTCTGGGTTGGTGGT
TGCCCTGGATGTTGATGCAACCCTGGAGCATGTGCAGGATCCTCAGAACACTGTTAAGGTCCAGGTCTTATATCCAGATGGCCAGGCTCA
GATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGCGGCACCGGCTCATCACTCAGGTTTATCTCTCCCACACCGCTTG
GACAGAGGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACTCCAGTGCTCGCATTCCAAAATGCCCCTGGATGGAGGGTGGTGA
GATGTCACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCAGCAAGCCTGTAAAAGTTTATATAATGCCCAAACCTGCACGGCG
CTAAGGCAAAAACAGTCTTCCCAACCGTGGCCTAGAGGGCCCTTCTTAGGTGTCAGAATGAGCCAAGCCTGAAGCACTTCACCTGGAATT
GATGTGTAGGCTTAAGGAGTATGTGACCCTTACAGTCTCATCTGGTATCAAACACAGGATAAATTGTTTCTTCATTAAAAAATAAAAAAC

>In-frame_ENST00000356136_ENST00000534064_TCGA-A1-A0SJ-01A_UVRAG_chr11_75623083_+_INTS4_chr11_77618856_length(amino acids)=546AA_start in transcript=163_stop in transcript=1803
MVGGGKGAAADAGRVPAPPLGGPWIEMSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDT
YFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEII
FGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYL
KQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFV
DKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLY
PDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIM

--------------------------------------------------------------
>In-frame_ENST00000356136_ENST00000535943_TCGA-A1-A0SJ-01A_UVRAG_chr11_75623083_+_INTS4_chr11_77618856_length(transcript)=2031nt_BP=834nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGCG
GCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTTACACTTCACTT
GTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGTCTCGATTTTGG
AATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAGCTGTTGATTGA
ATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGGCTGAATGATGG
ATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGTGTTCGCAATTC
TTACGATGTCTTCTCTTTGCTACGGGATCTGCAAAGACTTGGAGAACTTCAATCTGAATTGGCAGGAGTAGCTGATTTCTCTGCCACCTA
TCTTCGCTGTCAACTACTTCTCATCAAGGCCTTGCAGGAAAAGTTGTGGAATGTAGCTGCCCCTTTGTATTTGAAGCAGAGTGATTTGGC
CTCAGCAGCAGCGAAACAGATTATGGAAGAGACCTACAAAATGGAATTCATGTACAGTGGTGTGGAGAATAAGCAGGTGGTGATTATACA
TCACATGAGGCTGCAGGCCAAAGCTTTGCAACTTATAGTAACAGCACGAACTACACGAGGACTTGACCCCTTATTTGGGATGTGTGAAAA
ATTTTTACAGGAAGTAGACTTTTTTCAGAGGTATTTCATCGCTGATTTGCCCCACTTGCAGGACAGCTTTGTGGACAAACTCCTTGACCT
TATGCCCCGACTCATGACATCCAAACCTGCAGAAGTGGTCAAAATTCTACAGACCATGCTGCGACAGAGTGCCTTTCTGCATCTCCCGCT
TCCAGAGCAGATCCACAAAGCCTCAGCCACCATCATCGAGCCAGCGGGCGAGTCAGACAACCCTTTGCGGTTTACCTCTGGGTTGGTGGT
TGCCCTGGATGTTGATGCAACCCTGGAGCATGTGCAGGATCCTCAGAACACTGTTAAGGTCCAGGTCTTATATCCAGATGGCCAGGCTCA
GATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGCGGCACCGGCTCATCACTCAGGTTTATCTCTCCCACACCGCTTG
GACAGAGGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACTCCAGTGCTCGCATTCCAAAATGCCCCTGGATGGAGGGTGGTGA
GATGTCACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCAGCAAGCCTGTAAAAGTTTATATAATGCCCAAACCTGCACGGCG
CTAAGGCAAAAACAGTCTTCCCAACCGTGGCCTAGAGGGCCCTTCTTAGGTGTCAGAATGAGCCAAGCCTGAAGCACTTCACCTGGAATT
GATGTGTAGGCTTAAGGAGTATGTGACCCTTACAGTCTCATCTGGTATCAAACACAGGATAAATTGTTTCTTCATTAAAAAATAAAAAAC

>In-frame_ENST00000356136_ENST00000535943_TCGA-A1-A0SJ-01A_UVRAG_chr11_75623083_+_INTS4_chr11_77618856_length(amino acids)=546AA_start in transcript=163_stop in transcript=1803
MVGGGKGAAADAGRVPAPPLGGPWIEMSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDT
YFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEII
FGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYL
KQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFV
DKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLY
PDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIM

--------------------------------------------------------------
>In-frame_ENST00000528420_ENST00000534064_TCGA-A1-A0SJ-01A_UVRAG_chr11_75623083_+_INTS4_chr11_77618856_length(transcript)=1774nt_BP=575nt
AGTGCTCAGCTCCCTTGCCATGCGATACCCTGCAAGTCCTCACCAGCAAAAAGGCTCTCACCAGAGGCTGCCCCTCGGCCTGTGTTATCA
GATTTTTTGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTT
ACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGT
CTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAG
CTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGG
CTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGT
GTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGGATCTGCAAAGACTTGGAGAACTTCAATCTGAATTGGCAGGAGTAGCTGATTTC
TCTGCCACCTATCTTCGCTGTCAACTACTTCTCATCAAGGCCTTGCAGGAAAAGTTGTGGAATGTAGCTGCCCCTTTGTATTTGAAGCAG
AGTGATTTGGCCTCAGCAGCAGCGAAACAGATTATGGAAGAGACCTACAAAATGGAATTCATGTACAGTGGTGTGGAGAATAAGCAGGTG
GTGATTATACATCACATGAGGCTGCAGGCCAAAGCTTTGCAACTTATAGTAACAGCACGAACTACACGAGGACTTGACCCCTTATTTGGG
ATGTGTGAAAAATTTTTACAGGAAGTAGACTTTTTTCAGAGGTATTTCATCGCTGATTTGCCCCACTTGCAGGACAGCTTTGTGGACAAA
CTCCTTGACCTTATGCCCCGACTCATGACATCCAAACCTGCAGAAGTGGTCAAAATTCTACAGACCATGCTGCGACAGAGTGCCTTTCTG
CATCTCCCGCTTCCAGAGCAGATCCACAAAGCCTCAGCCACCATCATCGAGCCAGCGGGCGAGTCAGACAACCCTTTGCGGTTTACCTCT
GGGTTGGTGGTTGCCCTGGATGTTGATGCAACCCTGGAGCATGTGCAGGATCCTCAGAACACTGTTAAGGTCCAGGTCTTATATCCAGAT
GGCCAGGCTCAGATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGCGGCACCGGCTCATCACTCAGGTTTATCTCTCC
CACACCGCTTGGACAGAGGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACTCCAGTGCTCGCATTCCAAAATGCCCCTGGATG
GAGGGTGGTGAGATGTCACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCAGCAAGCCTGTAAAAGTTTATATAATGCCCAAA
CCTGCACGGCGCTAAGGCAAAAACAGTCTTCCCAACCGTGGCCTAGAGGGCCCTTCTTAGGTGTCAGAATGAGCCAAGCCTGAAGCACTT
CACCTGGAATTGATGTGTAGGCTTAAGGAGTATGTGACCCTTACAGTCTCATCTGGTATCAAACACAGGATAAATTGTTTCTTCATTAAA

>In-frame_ENST00000528420_ENST00000534064_TCGA-A1-A0SJ-01A_UVRAG_chr11_75623083_+_INTS4_chr11_77618856_length(amino acids)=482AA_start in transcript=96_stop in transcript=1544
MRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLL
IEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRDLQRLGELQSELAGVADFSA
TYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMC
EKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGL
VVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLLLAYNSSARIPKCPWMEG

--------------------------------------------------------------
>In-frame_ENST00000528420_ENST00000535943_TCGA-A1-A0SJ-01A_UVRAG_chr11_75623083_+_INTS4_chr11_77618856_length(transcript)=1772nt_BP=575nt
AGTGCTCAGCTCCCTTGCCATGCGATACCCTGCAAGTCCTCACCAGCAAAAAGGCTCTCACCAGAGGCTGCCCCTCGGCCTGTGTTATCA
GATTTTTTGCGGCGTCTTCGACATCTTCGGAACATTGCTGCCCGGAACATTGTTAATAGAAATGGCCATCAGCTCCTTGATACCTACTTT
ACACTTCACTTGTGTAGTACTGAAAAGATATATAAAGAATTTTATAGAAGTGAAGTGATTAAGAATTCCTTGAATCCCACGTGGCGAAGT
CTCGATTTTGGAATTATGCCAGACCGTCTTGATACATCTGTGTCTTGTTTCGTGGTGAAGATATGGGGTGGAAAGGAGAACATCTACCAG
CTGTTGATTGAATGGAAAGTCTGTTTGGATGGGCTGAAATACTTGGGTCAGCAGATTCATGCCCGAAACCAAAATGAAATAATTTTTGGG
CTGAATGATGGATACTATGGTGCTCCATTTGAACATAAGGGTTATTCAAATGCTCAGAAGACTATTCTTCTGCAGGTGGATCAGAACTGT
GTTCGCAATTCTTACGATGTCTTCTCTTTGCTACGGGATCTGCAAAGACTTGGAGAACTTCAATCTGAATTGGCAGGAGTAGCTGATTTC
TCTGCCACCTATCTTCGCTGTCAACTACTTCTCATCAAGGCCTTGCAGGAAAAGTTGTGGAATGTAGCTGCCCCTTTGTATTTGAAGCAG
AGTGATTTGGCCTCAGCAGCAGCGAAACAGATTATGGAAGAGACCTACAAAATGGAATTCATGTACAGTGGTGTGGAGAATAAGCAGGTG
GTGATTATACATCACATGAGGCTGCAGGCCAAAGCTTTGCAACTTATAGTAACAGCACGAACTACACGAGGACTTGACCCCTTATTTGGG
ATGTGTGAAAAATTTTTACAGGAAGTAGACTTTTTTCAGAGGTATTTCATCGCTGATTTGCCCCACTTGCAGGACAGCTTTGTGGACAAA
CTCCTTGACCTTATGCCCCGACTCATGACATCCAAACCTGCAGAAGTGGTCAAAATTCTACAGACCATGCTGCGACAGAGTGCCTTTCTG
CATCTCCCGCTTCCAGAGCAGATCCACAAAGCCTCAGCCACCATCATCGAGCCAGCGGGCGAGTCAGACAACCCTTTGCGGTTTACCTCT
GGGTTGGTGGTTGCCCTGGATGTTGATGCAACCCTGGAGCATGTGCAGGATCCTCAGAACACTGTTAAGGTCCAGGTCTTATATCCAGAT
GGCCAGGCTCAGATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGCGGCACCGGCTCATCACTCAGGTTTATCTCTCC
CACACCGCTTGGACAGAGGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACTCCAGTGCTCGCATTCCAAAATGCCCCTGGATG
GAGGGTGGTGAGATGTCACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCAGCAAGCCTGTAAAAGTTTATATAATGCCCAAA
CCTGCACGGCGCTAAGGCAAAAACAGTCTTCCCAACCGTGGCCTAGAGGGCCCTTCTTAGGTGTCAGAATGAGCCAAGCCTGAAGCACTT
CACCTGGAATTGATGTGTAGGCTTAAGGAGTATGTGACCCTTACAGTCTCATCTGGTATCAAACACAGGATAAATTGTTTCTTCATTAAA

>In-frame_ENST00000528420_ENST00000535943_TCGA-A1-A0SJ-01A_UVRAG_chr11_75623083_+_INTS4_chr11_77618856_length(amino acids)=482AA_start in transcript=96_stop in transcript=1544
MRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLL
IEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRDLQRLGELQSELAGVADFSA
TYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMC
EKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGL
VVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLLLAYNSSARIPKCPWMEG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for UVRAG-INTS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UVRAG-INTS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UVRAG-INTS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneINTS4C0033578Prostatic Neoplasms1CTD_human
TgeneINTS4C0376358Malignant neoplasm of prostate1CTD_human