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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UVRAG-RRAS2 (FusionGDB2 ID:97146)

Fusion Gene Summary for UVRAG-RRAS2

check button Fusion gene summary
Fusion gene informationFusion gene name: UVRAG-RRAS2
Fusion gene ID: 97146
HgeneTgene
Gene symbol

UVRAG

RRAS2

Gene ID

7405

22800

Gene nameUV radiation resistance associatedRAS related 2
SynonymsDHTX|VPS38|p63NS12|TC21
Cytomap

11q13.5

11p15.2

Type of geneprotein-codingprotein-coding
DescriptionUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxyras-related protein R-Ras2ras-like protein TC21related RAS viral (r-ras) oncogene homolog 2teratocarcinoma oncogene
Modification date2020031320200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000356136, ENST00000528420, 
ENST00000533454, ENST00000531818, 
ENST00000532130, ENST00000539288, 
ENST00000525872, ENST00000538870, 
ENST00000545643, ENST00000537760, 
ENST00000414023, ENST00000529237, 
ENST00000256196, ENST00000534746, 
ENST00000526063, ENST00000532814, 
Fusion gene scores* DoF score41 X 18 X 15=110705 X 2 X 5=50
# samples 495
** MAII scorelog2(49/11070*10)=-4.49772966266634
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: UVRAG [Title/Abstract] AND RRAS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUVRAG(75526569)-RRAS2(14317401), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

HgeneUVRAG

GO:0097352

autophagosome maturation

28306502

HgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840


check buttonFusion gene breakpoints across UVRAG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RRAS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-UF-A7JV-01AUVRAGchr11

75526569

+RRAS2chr11

14317401

-


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Fusion Gene ORF analysis for UVRAG-RRAS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356136ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
In-frameENST00000356136ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
In-frameENST00000356136ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000356136ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000356136ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000356136ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000356136ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000356136ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000528420ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000528420ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000528420ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000528420ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000528420ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000528420ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000528420ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000528420ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000533454ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000533454ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000533454ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000533454ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000533454ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000533454ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000533454ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000533454ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000531818ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000531818ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000531818ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000531818ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000531818ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000531818ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000531818ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000531818ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000532130ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000532130ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000532130ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000532130ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000532130ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000532130ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000532130ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000532130ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000539288ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000539288ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000539288ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000539288ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000539288ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000539288ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000539288ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000539288ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000525872ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000525872ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000525872ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000525872ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000525872ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000525872ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000525872ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000525872ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000538870ENST00000545643UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000538870ENST00000537760UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-3CDSENST00000538870ENST00000414023UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000538870ENST00000529237UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000538870ENST00000256196UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000538870ENST00000534746UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000538870ENST00000526063UVRAGchr11

75526569

+RRAS2chr11

14317401

-
intron-5UTRENST00000538870ENST00000532814UVRAGchr11

75526569

+RRAS2chr11

14317401

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356136UVRAGchr1175526569+ENST00000545643RRAS2chr1114317401-2276358153548131
ENST00000356136UVRAGchr1175526569+ENST00000537760RRAS2chr1114317401-2276358163864233
ENST00000356136UVRAGchr1175526569+ENST00000414023RRAS2chr1114317401-2242358299868189

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356136ENST00000545643UVRAGchr1175526569+RRAS2chr1114317401-0.823924840.17607516
ENST00000356136ENST00000537760UVRAGchr1175526569+RRAS2chr1114317401-0.0005096660.99949026
ENST00000356136ENST00000414023UVRAGchr1175526569+RRAS2chr1114317401-0.0012635120.99873644

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Fusion Genomic Features for UVRAG-RRAS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UVRAG-RRAS2


check button Go to

FGviewer for the breakpoints of chr11:75526569-chr11:14317401

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRRAS2chr11:75526569chr11:14317401ENST000002561960643_5136.0205.0MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST00000414023-1543_510128.0MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST000005260630643_510128.0MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST000005292370643_510128.0MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST000005328140643_510128.0MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST000005347460643_510128.0MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST000005377600643_511.0170.0MotifNote=Effector region
TgeneRRAS2chr11:75526569chr11:14317401ENST0000025619606127_13036.0205.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST0000025619606157_15936.0205.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST000002561960668_7236.0205.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000414023-15127_1300128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000414023-15157_1590128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000414023-1521_290128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST00000414023-1568_720128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST0000052606306127_1300128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST0000052606306157_1590128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST000005260630621_290128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST000005260630668_720128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST0000052923706127_1300128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST0000052923706157_1590128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST000005292370621_290128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST000005292370668_720128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST0000053281406127_1300128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST0000053281406157_1590128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST000005328140621_290128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST000005328140668_720128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST0000053474606127_1300128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST0000053474606157_1590128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST000005347460621_290128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST000005347460668_720128.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST0000053776006127_1301.0170.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST0000053776006157_1591.0170.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST000005377600621_291.0170.0Nucleotide bindingGTP
TgeneRRAS2chr11:75526569chr11:14317401ENST000005377600668_721.0170.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUVRAGchr11:75526569chr11:14317401ENST00000356136+115224_30539.0700.0Coiled coilOntology_term=ECO:0000255
HgeneUVRAGchr11:75526569chr11:14317401ENST00000356136+11523_14939.0700.0DomainC2
TgeneRRAS2chr11:75526569chr11:14317401ENST000002561960621_2936.0205.0Nucleotide bindingGTP


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Fusion Gene Sequence for UVRAG-RRAS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000356136_ENST00000545643_TCGA-UF-A7JV-01A_UVRAG_chr11_75526569_+_RRAS2_chr11_14317401_length(transcript)=2276nt_BP=358nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGGA
AATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATC
CCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTA
GACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAA
AGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACA
TTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCAT
ACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTT
AACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATA
CCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGG
TCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAA
AGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATAT
GGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATT
TTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTG
ACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCAC
ATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTAT
TTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAA
GCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGT
TTATAGAGCATACCCTTGTATAGCTTCAGGTGCTAGAATTAAAATTGATCTGTTATCGTAACACAGGAAGAAGGACAACAGTTAGCACGG
CAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGTTTT
GAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTG
GATCATCAAAGACAGTTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGT
TGGTCTTTTCAGTCACAGATAGAGGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGAT

>In-frame_ENST00000356136_ENST00000545643_TCGA-UF-A7JV-01A_UVRAG_chr11_75526569_+_RRAS2_chr11_14317401_length(amino acids)=131AA_start in transcript=153_stop in transcript=548
MQGLGRWWQGGGGGCRKSARPAAWRPLDRDERLRVGRGPRPPATPGPGRCSASRFCRAGPACGAAVSAGNFKSRNVLLHQNQHGKKKTRK

--------------------------------------------------------------
>In-frame_ENST00000356136_ENST00000537760_TCGA-UF-A7JV-01A_UVRAG_chr11_75526569_+_RRAS2_chr11_14317401_length(transcript)=2276nt_BP=358nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGTC
CTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTT
GGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGA
TAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAA
TAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATC
AGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACC
AGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAA
AGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGA
AGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATC
TGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCT
AAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATA
GGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAA
AGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAA
CTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGAT
ATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAA
GTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATT
AATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCAT
AGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAAC
TGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGT
ACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGAT
AATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGA
TGCTAAGTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAGAGCATACCCTTGTATAGCTTCAGGT

>In-frame_ENST00000356136_ENST00000537760_TCGA-UF-A7JV-01A_UVRAG_chr11_75526569_+_RRAS2_chr11_14317401_length(amino acids)=233AA_start in transcript=163_stop in transcript=864
MVGGGKGAAADAGRVPAPPLGGPWIEMSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQSYFVTDYDPTIEDSYTKQCVIDDRA
ARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKV

--------------------------------------------------------------
>In-frame_ENST00000356136_ENST00000414023_TCGA-UF-A7JV-01A_UVRAG_chr11_75526569_+_RRAS2_chr11_14317401_length(transcript)=2242nt_BP=358nt
AATGAGCGCTCCGGGTCTCAGCGGGGTGGAGGGGTTGCACTGCGGTAATATGGCTCTTCCTTAGCCAGCGGCGGCAACGGCGGCAGCGGC
GGCAGCGGCGGCGGCTACTGTCTGGGCTGAGCAGTAGTGCCTCTCGGGTGGCGGGTTTCTAGGCTGCAGGGGCTTGGTAGGTGGTGGCAA
GGGGGCGGCGGCGGATGCCGGAAGAGTGCCCGCCCCGCCGCTTGGCGGCCCCTGGATCGAGATGAGCGCCTCCGCGTCGGTCGGGGGCCC
CGTCCCCCAGCCACCCCCGGGCCCGGCCGCTGCTCTGCCTCCCGGTTCTGCCGCGCGGGCCCTGCATGTGGAGCTGCCGTCTCAGCAGGC
AGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATA
TTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCA
CAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTG
GTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGG
CATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTT
CACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAG
GAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAG
ACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGAT
TATCTGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGA
ATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAA
TATAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTA
CAAAAGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTA
AAAACTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTT
AGATATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTT
TCAAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGAT
GATTAATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTT
TCATAGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAG
AAACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATA
GAGTACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAAT
GGATAATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTT

>In-frame_ENST00000356136_ENST00000414023_TCGA-UF-A7JV-01A_UVRAG_chr11_75526569_+_RRAS2_chr11_14317401_length(amino acids)=189AA_start in transcript=299_stop in transcript=868
MLCLPVLPRGPCMWSCRLSRQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIY
KFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPSPEPTRKEKD

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Fusion Gene PPI Analysis for UVRAG-RRAS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UVRAG-RRAS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UVRAG-RRAS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRRAS2C0028326Noonan Syndrome3CLINGEN;GENOMICS_ENGLAND;ORPHANET
TgeneRRAS2C0019207Hepatoma, Morris1CTD_human
TgeneRRAS2C0019208Hepatoma, Novikoff1CTD_human
TgeneRRAS2C0023904Liver Neoplasms, Experimental1CTD_human
TgeneRRAS2C0086404Experimental Hepatoma1CTD_human
TgeneRRAS2C0349639Juvenile Myelomonocytic Leukemia1CTD_human