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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VAC14-WWOX (FusionGDB2 ID:97176)

Fusion Gene Summary for VAC14-WWOX

check button Fusion gene summary
Fusion gene informationFusion gene name: VAC14-WWOX
Fusion gene ID: 97176
HgeneTgene
Gene symbol

VAC14

WWOX

Gene ID

55697

51741

Gene nameVAC14 component of PIKFYVE complexWW domain containing oxidoreductase
SynonymsArPIKfyve|TAX1BP2|TRXD16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
Cytomap

16q22.1-q22.2

16q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptionprotein VAC14 homologTax1 (human T-cell leukemia virus type I) binding proteinVac14, PIKFYVE complex componentWW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261776, ENST00000571759, 
ENST00000536184, 		ENST00000566780, 
ENST00000406884, ENST00000539474, 
ENST00000402655, ENST00000408984, 
ENST00000355860, ENST00000565791, 
ENST00000569818, 
Fusion gene scores* DoF score5 X 6 X 4=12030 X 23 X 10=6900
# samples 636
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/6900*10)=-4.26052755022322
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VAC14 [Title/Abstract] AND WWOX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVAC14(70765398)-WWOX(79245505), # samples:3
Anticipated loss of major functional domain due to fusion event.VAC14-WWOX seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
VAC14-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
VAC14-WWOX seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
VAC14-WWOX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

TgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check buttonFusion gene breakpoints across VAC14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across WWOX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-BT-A20V-01AVAC14chr16

70765398

-WWOXchr16

79245505

+
ChimerDB4BLCATCGA-BT-A20VVAC14chr16

70765397

-WWOXchr16

79245504

+
ChimerDB4BLCATCGA-BT-A20V-01AVAC14chr16

70765398

-WWOXchr16

79245505

+
ChimerDB4BLCATCGA-BT-A20V-01AVAC14chr16

70732540

-WWOXchr16

79245505

+
ChimerDB4BLCATCGA-BT-A20V-01AVAC14chr16

70765398

-WWOXchr16

79245505

+


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Fusion Gene ORF analysis for VAC14-WWOX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000261776ENST00000566780VAC14chr16

70765398

-WWOXchr16

79245505

+
In-frameENST00000261776ENST00000406884VAC14chr16

70765398

-WWOXchr16

79245505

+
Frame-shiftENST00000261776ENST00000539474VAC14chr16

70765398

-WWOXchr16

79245505

+
Frame-shiftENST00000261776ENST00000402655VAC14chr16

70765398

-WWOXchr16

79245505

+
5CDS-intronENST00000261776ENST00000408984VAC14chr16

70765398

-WWOXchr16

79245505

+
5CDS-intronENST00000261776ENST00000355860VAC14chr16

70765398

-WWOXchr16

79245505

+
5CDS-intronENST00000261776ENST00000565791VAC14chr16

70765398

-WWOXchr16

79245505

+
5CDS-intronENST00000261776ENST00000569818VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000571759ENST00000566780VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000571759ENST00000406884VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000571759ENST00000539474VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000571759ENST00000402655VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000571759ENST00000408984VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000571759ENST00000355860VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000571759ENST00000565791VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000571759ENST00000569818VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000536184ENST00000566780VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000536184ENST00000406884VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000536184ENST00000539474VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-3CDSENST00000536184ENST00000402655VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000536184ENST00000408984VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000536184ENST00000355860VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000536184ENST00000565791VAC14chr16

70765398

-WWOXchr16

79245505

+
intron-intronENST00000536184ENST00000569818VAC14chr16

70765398

-WWOXchr16

79245505

+
In-frameENST00000261776ENST00000566780VAC14chr16

70765397

-WWOXchr16

79245504

+
In-frameENST00000261776ENST00000406884VAC14chr16

70765397

-WWOXchr16

79245504

+
Frame-shiftENST00000261776ENST00000539474VAC14chr16

70765397

-WWOXchr16

79245504

+
Frame-shiftENST00000261776ENST00000402655VAC14chr16

70765397

-WWOXchr16

79245504

+
5CDS-intronENST00000261776ENST00000408984VAC14chr16

70765397

-WWOXchr16

79245504

+
5CDS-intronENST00000261776ENST00000355860VAC14chr16

70765397

-WWOXchr16

79245504

+
5CDS-intronENST00000261776ENST00000565791VAC14chr16

70765397

-WWOXchr16

79245504

+
5CDS-intronENST00000261776ENST00000569818VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-3CDSENST00000571759ENST00000566780VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-3CDSENST00000571759ENST00000406884VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-3CDSENST00000571759ENST00000539474VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-3CDSENST00000571759ENST00000402655VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-intronENST00000571759ENST00000408984VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-intronENST00000571759ENST00000355860VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-intronENST00000571759ENST00000565791VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-intronENST00000571759ENST00000569818VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-3CDSENST00000536184ENST00000566780VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-3CDSENST00000536184ENST00000406884VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-3CDSENST00000536184ENST00000539474VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-3CDSENST00000536184ENST00000402655VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-intronENST00000536184ENST00000408984VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-intronENST00000536184ENST00000355860VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-intronENST00000536184ENST00000565791VAC14chr16

70765397

-WWOXchr16

79245504

+
intron-intronENST00000536184ENST00000569818VAC14chr16

70765397

-WWOXchr16

79245504

+
Frame-shiftENST00000261776ENST00000566780VAC14chr16

70732540

-WWOXchr16

79245505

+
Frame-shiftENST00000261776ENST00000406884VAC14chr16

70732540

-WWOXchr16

79245505

+
In-frameENST00000261776ENST00000539474VAC14chr16

70732540

-WWOXchr16

79245505

+
Frame-shiftENST00000261776ENST00000402655VAC14chr16

70732540

-WWOXchr16

79245505

+
5CDS-intronENST00000261776ENST00000408984VAC14chr16

70732540

-WWOXchr16

79245505

+
5CDS-intronENST00000261776ENST00000355860VAC14chr16

70732540

-WWOXchr16

79245505

+
5CDS-intronENST00000261776ENST00000565791VAC14chr16

70732540

-WWOXchr16

79245505

+
5CDS-intronENST00000261776ENST00000569818VAC14chr16

70732540

-WWOXchr16

79245505

+
intron-3CDSENST00000571759ENST00000566780VAC14chr16

70732540

-WWOXchr16

79245505

+
intron-3CDSENST00000571759ENST00000406884VAC14chr16

70732540

-WWOXchr16

79245505

+
intron-3CDSENST00000571759ENST00000539474VAC14chr16

70732540

-WWOXchr16

79245505

+
intron-3CDSENST00000571759ENST00000402655VAC14chr16

70732540

-WWOXchr16

79245505

+
intron-intronENST00000571759ENST00000408984VAC14chr16

70732540

-WWOXchr16

79245505

+
intron-intronENST00000571759ENST00000355860VAC14chr16

70732540

-WWOXchr16

79245505

+
intron-intronENST00000571759ENST00000565791VAC14chr16

70732540

-WWOXchr16

79245505

+
intron-intronENST00000571759ENST00000569818VAC14chr16

70732540

-WWOXchr16

79245505

+
Frame-shiftENST00000536184ENST00000566780VAC14chr16

70732540

-WWOXchr16

79245505

+
Frame-shiftENST00000536184ENST00000406884VAC14chr16

70732540

-WWOXchr16

79245505

+
In-frameENST00000536184ENST00000539474VAC14chr16

70732540

-WWOXchr16

79245505

+
Frame-shiftENST00000536184ENST00000402655VAC14chr16

70732540

-WWOXchr16

79245505

+
5CDS-intronENST00000536184ENST00000408984VAC14chr16

70732540

-WWOXchr16

79245505

+
5CDS-intronENST00000536184ENST00000355860VAC14chr16

70732540

-WWOXchr16

79245505

+
5CDS-intronENST00000536184ENST00000565791VAC14chr16

70732540

-WWOXchr16

79245505

+
5CDS-intronENST00000536184ENST00000569818VAC14chr16

70732540

-WWOXchr16

79245505

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261776VAC14chr1670765398-ENST00000566780WWOXchr1679245505+298219222612078605
ENST00000261776VAC14chr1670765398-ENST00000406884WWOXchr1679245505+298219222612078605
ENST00000261776VAC14chr1670765397-ENST00000566780WWOXchr1679245504+298219222612078605
ENST00000261776VAC14chr1670765397-ENST00000406884WWOXchr1679245504+298219222612078605
ENST00000261776VAC14chr1670732540-ENST00000539474WWOXchr1679245505+315720972612285674
ENST00000536184VAC14chr1670732540-ENST00000539474WWOXchr1679245505+222211629001688262

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261776ENST00000566780VAC14chr1670765398-WWOXchr1679245505+0.0052760510.994724
ENST00000261776ENST00000406884VAC14chr1670765398-WWOXchr1679245505+0.0052760510.994724
ENST00000261776ENST00000566780VAC14chr1670765397-WWOXchr1679245504+0.0052760510.994724
ENST00000261776ENST00000406884VAC14chr1670765397-WWOXchr1679245504+0.0052760510.994724
ENST00000261776ENST00000539474VAC14chr1670732540-WWOXchr1679245505+0.0062065750.99379337
ENST00000536184ENST00000539474VAC14chr1670732540-WWOXchr1679245505+0.78616280.21383719

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Fusion Genomic Features for VAC14-WWOX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
VAC14chr1670765397-WWOXchr1679245504+4.16E-050.9999584
VAC14chr1670765397-WWOXchr1679245504+4.16E-050.9999584
VAC14chr1670732539-WWOXchr1679245504+1.75E-081
VAC14chr1670765397-WWOXchr1679245504+4.16E-050.9999584
VAC14chr1670765397-WWOXchr1679245504+4.16E-050.9999584
VAC14chr1670732539-WWOXchr1679245504+1.75E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VAC14-WWOX


check button Go to

FGviewer for the breakpoints of chr16:70765398-chr16:79245505

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVAC14chr16:70732540chr16:79245505ENST00000261776-1519171_208612.0783.0RepeatNote=HEAT 3
HgeneVAC14chr16:70732540chr16:79245505ENST00000261776-1519212_249612.0783.0RepeatNote=HEAT 4
HgeneVAC14chr16:70732540chr16:79245505ENST00000261776-1519438_475612.0783.0RepeatNote=HEAT 5
HgeneVAC14chr16:70732540chr16:79245505ENST00000261776-1519560_598612.0783.0RepeatNote=HEAT 6
HgeneVAC14chr16:70732540chr16:79245505ENST00000261776-15195_42612.0783.0RepeatNote=HEAT 1
HgeneVAC14chr16:70732540chr16:79245505ENST00000261776-151989_126612.0783.0RepeatNote=HEAT 2
HgeneVAC14chr16:70765397chr16:79245504ENST00000261776-1419171_208553.6666666666666783.0RepeatNote=HEAT 3
HgeneVAC14chr16:70765397chr16:79245504ENST00000261776-1419212_249553.6666666666666783.0RepeatNote=HEAT 4
HgeneVAC14chr16:70765397chr16:79245504ENST00000261776-1419438_475553.6666666666666783.0RepeatNote=HEAT 5
HgeneVAC14chr16:70765397chr16:79245504ENST00000261776-14195_42553.6666666666666783.0RepeatNote=HEAT 1
HgeneVAC14chr16:70765397chr16:79245504ENST00000261776-141989_126553.6666666666666783.0RepeatNote=HEAT 2
HgeneVAC14chr16:70765398chr16:79245505ENST00000261776-1419171_208553.6666666666666783.0RepeatNote=HEAT 3
HgeneVAC14chr16:70765398chr16:79245505ENST00000261776-1419212_249553.6666666666666783.0RepeatNote=HEAT 4
HgeneVAC14chr16:70765398chr16:79245505ENST00000261776-1419438_475553.6666666666666783.0RepeatNote=HEAT 5
HgeneVAC14chr16:70765398chr16:79245505ENST00000261776-14195_42553.6666666666666783.0RepeatNote=HEAT 1
HgeneVAC14chr16:70765398chr16:79245505ENST00000261776-141989_126553.6666666666666783.0RepeatNote=HEAT 2
TgeneWWOXchr16:70732540chr16:79245505ENST000003558600616_490190.0DomainWW 1
TgeneWWOXchr16:70732540chr16:79245505ENST000003558600657_900190.0DomainWW 2
TgeneWWOXchr16:70732540chr16:79245505ENST0000040898401016_490311.6666666666667DomainWW 1
TgeneWWOXchr16:70732540chr16:79245505ENST0000040898401057_900311.6666666666667DomainWW 2
TgeneWWOXchr16:70732540chr16:79245505ENST000005698180116_49037.0DomainWW 1
TgeneWWOXchr16:70732540chr16:79245505ENST000005698180157_90037.0DomainWW 2
TgeneWWOXchr16:70765397chr16:79245504ENST000003558600616_490190.0DomainWW 1
TgeneWWOXchr16:70765397chr16:79245504ENST000003558600657_900190.0DomainWW 2
TgeneWWOXchr16:70765397chr16:79245504ENST0000040898401016_490311.6666666666667DomainWW 1
TgeneWWOXchr16:70765397chr16:79245504ENST0000040898401057_900311.6666666666667DomainWW 2
TgeneWWOXchr16:70765397chr16:79245504ENST000005698180116_49037.0DomainWW 1
TgeneWWOXchr16:70765397chr16:79245504ENST000005698180157_90037.0DomainWW 2
TgeneWWOXchr16:70765398chr16:79245505ENST000003558600616_490190.0DomainWW 1
TgeneWWOXchr16:70765398chr16:79245505ENST000003558600657_900190.0DomainWW 2
TgeneWWOXchr16:70765398chr16:79245505ENST0000040898401016_490311.6666666666667DomainWW 1
TgeneWWOXchr16:70765398chr16:79245505ENST0000040898401057_900311.6666666666667DomainWW 2
TgeneWWOXchr16:70765398chr16:79245505ENST000005698180116_49037.0DomainWW 1
TgeneWWOXchr16:70765398chr16:79245505ENST000005698180157_90037.0DomainWW 2
TgeneWWOXchr16:70732540chr16:79245505ENST000003558600650_550190.0MotifNuclear localization signal
TgeneWWOXchr16:70732540chr16:79245505ENST0000040898401050_550311.6666666666667MotifNuclear localization signal
TgeneWWOXchr16:70732540chr16:79245505ENST000005698180150_55037.0MotifNuclear localization signal
TgeneWWOXchr16:70765397chr16:79245504ENST000003558600650_550190.0MotifNuclear localization signal
TgeneWWOXchr16:70765397chr16:79245504ENST0000040898401050_550311.6666666666667MotifNuclear localization signal
TgeneWWOXchr16:70765397chr16:79245504ENST000005698180150_55037.0MotifNuclear localization signal
TgeneWWOXchr16:70765398chr16:79245505ENST000003558600650_550190.0MotifNuclear localization signal
TgeneWWOXchr16:70765398chr16:79245505ENST0000040898401050_550311.6666666666667MotifNuclear localization signal
TgeneWWOXchr16:70765398chr16:79245505ENST000005698180150_55037.0MotifNuclear localization signal
TgeneWWOXchr16:70732540chr16:79245505ENST0000035586006131_1370190.0Nucleotide bindingNADP
TgeneWWOXchr16:70732540chr16:79245505ENST00000408984010131_1370311.6666666666667Nucleotide bindingNADP
TgeneWWOXchr16:70732540chr16:79245505ENST0000056981801131_137037.0Nucleotide bindingNADP
TgeneWWOXchr16:70765397chr16:79245504ENST0000035586006131_1370190.0Nucleotide bindingNADP
TgeneWWOXchr16:70765397chr16:79245504ENST00000408984010131_1370311.6666666666667Nucleotide bindingNADP
TgeneWWOXchr16:70765397chr16:79245504ENST0000056981801131_137037.0Nucleotide bindingNADP
TgeneWWOXchr16:70765398chr16:79245505ENST0000035586006131_1370190.0Nucleotide bindingNADP
TgeneWWOXchr16:70765398chr16:79245505ENST00000408984010131_1370311.6666666666667Nucleotide bindingNADP
TgeneWWOXchr16:70765398chr16:79245505ENST0000056981801131_137037.0Nucleotide bindingNADP
TgeneWWOXchr16:70732540chr16:79245505ENST0000035586006209_2730190.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70732540chr16:79245505ENST0000040265535209_273136.33333333333334312.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70732540chr16:79245505ENST0000040688446209_273172.0235.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70732540chr16:79245505ENST00000408984010209_2730311.6666666666667RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70732540chr16:79245505ENST0000056981801209_273037.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765397chr16:79245504ENST0000035586006209_2730190.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765397chr16:79245504ENST0000040265535209_273136.33333333333334312.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765397chr16:79245504ENST0000040688446209_273172.0235.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765397chr16:79245504ENST00000408984010209_2730311.6666666666667RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765397chr16:79245504ENST0000056981801209_273037.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765398chr16:79245505ENST0000035586006209_2730190.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765398chr16:79245505ENST0000040265535209_273136.33333333333334312.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765398chr16:79245505ENST0000040688446209_273172.0235.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765398chr16:79245505ENST00000408984010209_2730311.6666666666667RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765398chr16:79245505ENST0000056981801209_273037.0RegionMediates targeting to the mitochondria

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVAC14chr16:70765397chr16:79245504ENST00000261776-1419560_598553.6666666666666783.0RepeatNote=HEAT 6
HgeneVAC14chr16:70765398chr16:79245505ENST00000261776-1419560_598553.6666666666666783.0RepeatNote=HEAT 6
TgeneWWOXchr16:70732540chr16:79245505ENST000004026553516_49136.33333333333334312.0DomainWW 1
TgeneWWOXchr16:70732540chr16:79245505ENST000004026553557_90136.33333333333334312.0DomainWW 2
TgeneWWOXchr16:70732540chr16:79245505ENST000004068844616_49172.0235.0DomainWW 1
TgeneWWOXchr16:70732540chr16:79245505ENST000004068844657_90172.0235.0DomainWW 2
TgeneWWOXchr16:70732540chr16:79245505ENST000005667807916_49352.0415.0DomainWW 1
TgeneWWOXchr16:70732540chr16:79245505ENST000005667807957_90352.0415.0DomainWW 2
TgeneWWOXchr16:70765397chr16:79245504ENST000004026553516_49136.33333333333334312.0DomainWW 1
TgeneWWOXchr16:70765397chr16:79245504ENST000004026553557_90136.33333333333334312.0DomainWW 2
TgeneWWOXchr16:70765397chr16:79245504ENST000004068844616_49172.0235.0DomainWW 1
TgeneWWOXchr16:70765397chr16:79245504ENST000004068844657_90172.0235.0DomainWW 2
TgeneWWOXchr16:70765397chr16:79245504ENST000005667807916_49352.0415.0DomainWW 1
TgeneWWOXchr16:70765397chr16:79245504ENST000005667807957_90352.0415.0DomainWW 2
TgeneWWOXchr16:70765398chr16:79245505ENST000004026553516_49136.33333333333334312.0DomainWW 1
TgeneWWOXchr16:70765398chr16:79245505ENST000004026553557_90136.33333333333334312.0DomainWW 2
TgeneWWOXchr16:70765398chr16:79245505ENST000004068844616_49172.0235.0DomainWW 1
TgeneWWOXchr16:70765398chr16:79245505ENST000004068844657_90172.0235.0DomainWW 2
TgeneWWOXchr16:70765398chr16:79245505ENST000005667807916_49352.0415.0DomainWW 1
TgeneWWOXchr16:70765398chr16:79245505ENST000005667807957_90352.0415.0DomainWW 2
TgeneWWOXchr16:70732540chr16:79245505ENST000004026553550_55136.33333333333334312.0MotifNuclear localization signal
TgeneWWOXchr16:70732540chr16:79245505ENST000004068844650_55172.0235.0MotifNuclear localization signal
TgeneWWOXchr16:70732540chr16:79245505ENST000005667807950_55352.0415.0MotifNuclear localization signal
TgeneWWOXchr16:70765397chr16:79245504ENST000004026553550_55136.33333333333334312.0MotifNuclear localization signal
TgeneWWOXchr16:70765397chr16:79245504ENST000004068844650_55172.0235.0MotifNuclear localization signal
TgeneWWOXchr16:70765397chr16:79245504ENST000005667807950_55352.0415.0MotifNuclear localization signal
TgeneWWOXchr16:70765398chr16:79245505ENST000004026553550_55136.33333333333334312.0MotifNuclear localization signal
TgeneWWOXchr16:70765398chr16:79245505ENST000004068844650_55172.0235.0MotifNuclear localization signal
TgeneWWOXchr16:70765398chr16:79245505ENST000005667807950_55352.0415.0MotifNuclear localization signal
TgeneWWOXchr16:70732540chr16:79245505ENST0000040265535131_137136.33333333333334312.0Nucleotide bindingNADP
TgeneWWOXchr16:70732540chr16:79245505ENST0000040688446131_137172.0235.0Nucleotide bindingNADP
TgeneWWOXchr16:70732540chr16:79245505ENST0000056678079131_137352.0415.0Nucleotide bindingNADP
TgeneWWOXchr16:70765397chr16:79245504ENST0000040265535131_137136.33333333333334312.0Nucleotide bindingNADP
TgeneWWOXchr16:70765397chr16:79245504ENST0000040688446131_137172.0235.0Nucleotide bindingNADP
TgeneWWOXchr16:70765397chr16:79245504ENST0000056678079131_137352.0415.0Nucleotide bindingNADP
TgeneWWOXchr16:70765398chr16:79245505ENST0000040265535131_137136.33333333333334312.0Nucleotide bindingNADP
TgeneWWOXchr16:70765398chr16:79245505ENST0000040688446131_137172.0235.0Nucleotide bindingNADP
TgeneWWOXchr16:70765398chr16:79245505ENST0000056678079131_137352.0415.0Nucleotide bindingNADP
TgeneWWOXchr16:70732540chr16:79245505ENST0000056678079209_273352.0415.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765397chr16:79245504ENST0000056678079209_273352.0415.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:70765398chr16:79245505ENST0000056678079209_273352.0415.0RegionMediates targeting to the mitochondria


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Fusion Gene Sequence for VAC14-WWOX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000261776_ENST00000566780_TCGA-BT-A20V-01A_VAC14_chr16_70765398_-_WWOX_chr16_79245505_length(transcript)=2982nt_BP=1922nt
TGTGACTCGAGTAACATGGCCGCTGTCTCGTGAGTCCCGCTAGTGCCGGGCGGGAGTTGTTAAGCGGCCAGGGTCAGGTGTGCTGGAGCG
GGGTCCGGGCCCGGGTTCCAGGGCGAGGCGGCGGAGCGTGGCAGGCAAGCCTAGAGCGGCGTGGTCCATGCGCCGGCGCCGGGGGCAGAG
CGGAGCCGCAGACTCCCCTGGCCCCGGCGCGGCCCCGGCAGCCGCGGGCTAAGGAGTCGCGAGGTTCCCCCAGCTGCCACCATGAACCCC
GAGAAGGATTTCGCGCCGCTCACGCCTAACATCGTGCGCGCCCTCAATGACAAGCTGTACGAAAAGCGGAAGGTGGCAGCGCTGGAGATC
GAGAAGCTGGTCCGGGAGTTCGTGGCCCAGAACAATACCGTGCAAATCAAGCATGTGATCCAGACCCTGTCCCAGGAGTTTGCCCTGTCT
CAGCACCCCCACAGCCGGAAAGGGGGCCTCATCGGCCTGGCCGCCTGCTCCATCGCACTGGGCAAGGACTCAGGGCTCTACCTGAAGGAG
CTGATCGAGCCAGTGCTGACCTGCTTCAATGATGCAGACAGCAGGCTGCGCTACTATGCCTGCGAGGCCCTCTACAACATCGTCAAGGTG
GCCCGGGGCGCTGTGCTGCCCCACTTCAACGTGCTCTTTGACGGGCTGAGCAAGCTGGCAGCCGACCCAGACCCCAATGTGAAAAGCGGA
TCTGAGCTCCTAGACCGCCTTTTAAAGGACATTGTGACTGAGAGCAACAAGTTTGACCTGGTGAGCTTCATCCCCTTGTTGCGAGAGAGG
ATTTACTCCAACAACCAGTATGCCCGGCAGTTCATCATCTCCTGGATCCTGGTTCTGGAGTCGGTGCCAGACATTAACCTGCTGGATTAC
CTGCCGGAGATCCTGGATGGACTCTTCCAGATCCTGGGTGACAATGGCAAAGAGATTCGCAAAATGTGTGAGGTTGTTCTTGGAGAATTC
TTAAAAGAAATTAAGAAGAACCCCTCCAGTGTGAAGTTTGCTGAGATGGCCAACATCCTGGTGATCCACTGCCAGACAACAGATGACCTC
ATCCAGCTGACAGCCATGTGCTGGATGCGGGAGTTCATCCAGCTGGCGGGCCGCGTCATGCTGCCTTACTCCTCCGGGATCCTGACTGCT
GTCTTGCCCTGCTTGGCCTACGATGACCGCAAGAAAAGCATCAAAGAAGTGGCCAACGTGTGCAACCAGAGCCTGATGAAGCTGGTCACC
CCCGAGGACGACGAGCTGGATGAGCTGAGACCTGGGCAGAGGCAGGCAGAGCCCACCCCTGACGATGCCCTGCCAAAGCAGGAGGGCACA
GCCAGTGGAGGTCCAGATGGTTCCTGTGACTCCAGCTTCAGTAGCGGCATCAGTGTCTTCACTGCAGCCAGCACTGAAAGAGCCCCAGTG
ACCCTTCACCTCGACGGGATCGTGCAGGTCCTAAACTGCCACCTCAGTGACACGGCCATTGGGATGATGACCAGGATTGCAGTTCTCAAG
TGGCTCTACCACCTCTACATCAAAACTCCTCGGAAGATGTTCCGGCACACGGACAGCCTCTTTCCCATCCTACTGCAGACGTTATCGGAT
GAATCGGATGAGGTGATCCTGAAGGACCTGGAGGTGCTGGCAGAAATCGCTTCCTCCCCCGCAGGCCAGACGGATGACCCAGGCCCCCTC
GATGGCCCTGACCTCCAGGCCAGCCACTCAGAGCTCCAGGTGCCCACCCCTGGCAGAGCCGGCCTACTGAACACCTCTGGTACCAAAGGC
TTAGAATGTTCTCCTTCAACTCCCACCATGAATTCTTACTTTTATAAGTTCATGATCAACCTTCTCAAGAGATTCAGCAGCGAACGGAAG
CTCCTGGAGGTCAGAGGCCCTTTCATCATCAGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGG
GAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCG
AGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCC
TCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGT
GAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTT
TCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTA
CTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGG
GAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGC
AACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAG
GTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGA
TACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTT
GTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATAAAAGAACAT

>In-frame_ENST00000261776_ENST00000566780_TCGA-BT-A20V-01A_VAC14_chr16_70765398_-_WWOX_chr16_79245505_length(amino acids)=605AA_start in transcript=261_stop in transcript=2078
MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLY
LKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVSFIPLL
RERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTT
DDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDELDELRPGQRQAEPTPDDALPKQ
EGTASGGPDGSCDSSFSSGISVFTAASTERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQT
LSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLQASHSELQVPTPGRAGLLNTSGTKGLECSPSTPTMNSYFYKFMINLLKRFSS

--------------------------------------------------------------
>In-frame_ENST00000261776_ENST00000406884_TCGA-BT-A20V-01A_VAC14_chr16_70765398_-_WWOX_chr16_79245505_length(transcript)=2982nt_BP=1922nt
TGTGACTCGAGTAACATGGCCGCTGTCTCGTGAGTCCCGCTAGTGCCGGGCGGGAGTTGTTAAGCGGCCAGGGTCAGGTGTGCTGGAGCG
GGGTCCGGGCCCGGGTTCCAGGGCGAGGCGGCGGAGCGTGGCAGGCAAGCCTAGAGCGGCGTGGTCCATGCGCCGGCGCCGGGGGCAGAG
CGGAGCCGCAGACTCCCCTGGCCCCGGCGCGGCCCCGGCAGCCGCGGGCTAAGGAGTCGCGAGGTTCCCCCAGCTGCCACCATGAACCCC
GAGAAGGATTTCGCGCCGCTCACGCCTAACATCGTGCGCGCCCTCAATGACAAGCTGTACGAAAAGCGGAAGGTGGCAGCGCTGGAGATC
GAGAAGCTGGTCCGGGAGTTCGTGGCCCAGAACAATACCGTGCAAATCAAGCATGTGATCCAGACCCTGTCCCAGGAGTTTGCCCTGTCT
CAGCACCCCCACAGCCGGAAAGGGGGCCTCATCGGCCTGGCCGCCTGCTCCATCGCACTGGGCAAGGACTCAGGGCTCTACCTGAAGGAG
CTGATCGAGCCAGTGCTGACCTGCTTCAATGATGCAGACAGCAGGCTGCGCTACTATGCCTGCGAGGCCCTCTACAACATCGTCAAGGTG
GCCCGGGGCGCTGTGCTGCCCCACTTCAACGTGCTCTTTGACGGGCTGAGCAAGCTGGCAGCCGACCCAGACCCCAATGTGAAAAGCGGA
TCTGAGCTCCTAGACCGCCTTTTAAAGGACATTGTGACTGAGAGCAACAAGTTTGACCTGGTGAGCTTCATCCCCTTGTTGCGAGAGAGG
ATTTACTCCAACAACCAGTATGCCCGGCAGTTCATCATCTCCTGGATCCTGGTTCTGGAGTCGGTGCCAGACATTAACCTGCTGGATTAC
CTGCCGGAGATCCTGGATGGACTCTTCCAGATCCTGGGTGACAATGGCAAAGAGATTCGCAAAATGTGTGAGGTTGTTCTTGGAGAATTC
TTAAAAGAAATTAAGAAGAACCCCTCCAGTGTGAAGTTTGCTGAGATGGCCAACATCCTGGTGATCCACTGCCAGACAACAGATGACCTC
ATCCAGCTGACAGCCATGTGCTGGATGCGGGAGTTCATCCAGCTGGCGGGCCGCGTCATGCTGCCTTACTCCTCCGGGATCCTGACTGCT
GTCTTGCCCTGCTTGGCCTACGATGACCGCAAGAAAAGCATCAAAGAAGTGGCCAACGTGTGCAACCAGAGCCTGATGAAGCTGGTCACC
CCCGAGGACGACGAGCTGGATGAGCTGAGACCTGGGCAGAGGCAGGCAGAGCCCACCCCTGACGATGCCCTGCCAAAGCAGGAGGGCACA
GCCAGTGGAGGTCCAGATGGTTCCTGTGACTCCAGCTTCAGTAGCGGCATCAGTGTCTTCACTGCAGCCAGCACTGAAAGAGCCCCAGTG
ACCCTTCACCTCGACGGGATCGTGCAGGTCCTAAACTGCCACCTCAGTGACACGGCCATTGGGATGATGACCAGGATTGCAGTTCTCAAG
TGGCTCTACCACCTCTACATCAAAACTCCTCGGAAGATGTTCCGGCACACGGACAGCCTCTTTCCCATCCTACTGCAGACGTTATCGGAT
GAATCGGATGAGGTGATCCTGAAGGACCTGGAGGTGCTGGCAGAAATCGCTTCCTCCCCCGCAGGCCAGACGGATGACCCAGGCCCCCTC
GATGGCCCTGACCTCCAGGCCAGCCACTCAGAGCTCCAGGTGCCCACCCCTGGCAGAGCCGGCCTACTGAACACCTCTGGTACCAAAGGC
TTAGAATGTTCTCCTTCAACTCCCACCATGAATTCTTACTTTTATAAGTTCATGATCAACCTTCTCAAGAGATTCAGCAGCGAACGGAAG
CTCCTGGAGGTCAGAGGCCCTTTCATCATCAGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGG
GAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCG
AGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCC
TCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGT
GAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTT
TCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTA
CTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGG
GAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGC
AACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAG
GTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGA
TACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTT
GTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATAAAAGAACAT

>In-frame_ENST00000261776_ENST00000406884_TCGA-BT-A20V-01A_VAC14_chr16_70765398_-_WWOX_chr16_79245505_length(amino acids)=605AA_start in transcript=261_stop in transcript=2078
MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLY
LKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVSFIPLL
RERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTT
DDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDELDELRPGQRQAEPTPDDALPKQ
EGTASGGPDGSCDSSFSSGISVFTAASTERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQT
LSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLQASHSELQVPTPGRAGLLNTSGTKGLECSPSTPTMNSYFYKFMINLLKRFSS

--------------------------------------------------------------
>In-frame_ENST00000261776_ENST00000566780_TCGA-BT-A20V_VAC14_chr16_70765397_-_WWOX_chr16_79245504_length(transcript)=2982nt_BP=1922nt
TGTGACTCGAGTAACATGGCCGCTGTCTCGTGAGTCCCGCTAGTGCCGGGCGGGAGTTGTTAAGCGGCCAGGGTCAGGTGTGCTGGAGCG
GGGTCCGGGCCCGGGTTCCAGGGCGAGGCGGCGGAGCGTGGCAGGCAAGCCTAGAGCGGCGTGGTCCATGCGCCGGCGCCGGGGGCAGAG
CGGAGCCGCAGACTCCCCTGGCCCCGGCGCGGCCCCGGCAGCCGCGGGCTAAGGAGTCGCGAGGTTCCCCCAGCTGCCACCATGAACCCC
GAGAAGGATTTCGCGCCGCTCACGCCTAACATCGTGCGCGCCCTCAATGACAAGCTGTACGAAAAGCGGAAGGTGGCAGCGCTGGAGATC
GAGAAGCTGGTCCGGGAGTTCGTGGCCCAGAACAATACCGTGCAAATCAAGCATGTGATCCAGACCCTGTCCCAGGAGTTTGCCCTGTCT
CAGCACCCCCACAGCCGGAAAGGGGGCCTCATCGGCCTGGCCGCCTGCTCCATCGCACTGGGCAAGGACTCAGGGCTCTACCTGAAGGAG
CTGATCGAGCCAGTGCTGACCTGCTTCAATGATGCAGACAGCAGGCTGCGCTACTATGCCTGCGAGGCCCTCTACAACATCGTCAAGGTG
GCCCGGGGCGCTGTGCTGCCCCACTTCAACGTGCTCTTTGACGGGCTGAGCAAGCTGGCAGCCGACCCAGACCCCAATGTGAAAAGCGGA
TCTGAGCTCCTAGACCGCCTTTTAAAGGACATTGTGACTGAGAGCAACAAGTTTGACCTGGTGAGCTTCATCCCCTTGTTGCGAGAGAGG
ATTTACTCCAACAACCAGTATGCCCGGCAGTTCATCATCTCCTGGATCCTGGTTCTGGAGTCGGTGCCAGACATTAACCTGCTGGATTAC
CTGCCGGAGATCCTGGATGGACTCTTCCAGATCCTGGGTGACAATGGCAAAGAGATTCGCAAAATGTGTGAGGTTGTTCTTGGAGAATTC
TTAAAAGAAATTAAGAAGAACCCCTCCAGTGTGAAGTTTGCTGAGATGGCCAACATCCTGGTGATCCACTGCCAGACAACAGATGACCTC
ATCCAGCTGACAGCCATGTGCTGGATGCGGGAGTTCATCCAGCTGGCGGGCCGCGTCATGCTGCCTTACTCCTCCGGGATCCTGACTGCT
GTCTTGCCCTGCTTGGCCTACGATGACCGCAAGAAAAGCATCAAAGAAGTGGCCAACGTGTGCAACCAGAGCCTGATGAAGCTGGTCACC
CCCGAGGACGACGAGCTGGATGAGCTGAGACCTGGGCAGAGGCAGGCAGAGCCCACCCCTGACGATGCCCTGCCAAAGCAGGAGGGCACA
GCCAGTGGAGGTCCAGATGGTTCCTGTGACTCCAGCTTCAGTAGCGGCATCAGTGTCTTCACTGCAGCCAGCACTGAAAGAGCCCCAGTG
ACCCTTCACCTCGACGGGATCGTGCAGGTCCTAAACTGCCACCTCAGTGACACGGCCATTGGGATGATGACCAGGATTGCAGTTCTCAAG
TGGCTCTACCACCTCTACATCAAAACTCCTCGGAAGATGTTCCGGCACACGGACAGCCTCTTTCCCATCCTACTGCAGACGTTATCGGAT
GAATCGGATGAGGTGATCCTGAAGGACCTGGAGGTGCTGGCAGAAATCGCTTCCTCCCCCGCAGGCCAGACGGATGACCCAGGCCCCCTC
GATGGCCCTGACCTCCAGGCCAGCCACTCAGAGCTCCAGGTGCCCACCCCTGGCAGAGCCGGCCTACTGAACACCTCTGGTACCAAAGGC
TTAGAATGTTCTCCTTCAACTCCCACCATGAATTCTTACTTTTATAAGTTCATGATCAACCTTCTCAAGAGATTCAGCAGCGAACGGAAG
CTCCTGGAGGTCAGAGGCCCTTTCATCATCAGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGG
GAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCG
AGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCC
TCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGT
GAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTT
TCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTA
CTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGG
GAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGC
AACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAG
GTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGA
TACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTT
GTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATAAAAGAACAT

>In-frame_ENST00000261776_ENST00000566780_TCGA-BT-A20V_VAC14_chr16_70765397_-_WWOX_chr16_79245504_length(amino acids)=605AA_start in transcript=261_stop in transcript=2078
MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLY
LKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVSFIPLL
RERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTT
DDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDELDELRPGQRQAEPTPDDALPKQ
EGTASGGPDGSCDSSFSSGISVFTAASTERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQT
LSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLQASHSELQVPTPGRAGLLNTSGTKGLECSPSTPTMNSYFYKFMINLLKRFSS

--------------------------------------------------------------
>In-frame_ENST00000261776_ENST00000406884_TCGA-BT-A20V_VAC14_chr16_70765397_-_WWOX_chr16_79245504_length(transcript)=2982nt_BP=1922nt
TGTGACTCGAGTAACATGGCCGCTGTCTCGTGAGTCCCGCTAGTGCCGGGCGGGAGTTGTTAAGCGGCCAGGGTCAGGTGTGCTGGAGCG
GGGTCCGGGCCCGGGTTCCAGGGCGAGGCGGCGGAGCGTGGCAGGCAAGCCTAGAGCGGCGTGGTCCATGCGCCGGCGCCGGGGGCAGAG
CGGAGCCGCAGACTCCCCTGGCCCCGGCGCGGCCCCGGCAGCCGCGGGCTAAGGAGTCGCGAGGTTCCCCCAGCTGCCACCATGAACCCC
GAGAAGGATTTCGCGCCGCTCACGCCTAACATCGTGCGCGCCCTCAATGACAAGCTGTACGAAAAGCGGAAGGTGGCAGCGCTGGAGATC
GAGAAGCTGGTCCGGGAGTTCGTGGCCCAGAACAATACCGTGCAAATCAAGCATGTGATCCAGACCCTGTCCCAGGAGTTTGCCCTGTCT
CAGCACCCCCACAGCCGGAAAGGGGGCCTCATCGGCCTGGCCGCCTGCTCCATCGCACTGGGCAAGGACTCAGGGCTCTACCTGAAGGAG
CTGATCGAGCCAGTGCTGACCTGCTTCAATGATGCAGACAGCAGGCTGCGCTACTATGCCTGCGAGGCCCTCTACAACATCGTCAAGGTG
GCCCGGGGCGCTGTGCTGCCCCACTTCAACGTGCTCTTTGACGGGCTGAGCAAGCTGGCAGCCGACCCAGACCCCAATGTGAAAAGCGGA
TCTGAGCTCCTAGACCGCCTTTTAAAGGACATTGTGACTGAGAGCAACAAGTTTGACCTGGTGAGCTTCATCCCCTTGTTGCGAGAGAGG
ATTTACTCCAACAACCAGTATGCCCGGCAGTTCATCATCTCCTGGATCCTGGTTCTGGAGTCGGTGCCAGACATTAACCTGCTGGATTAC
CTGCCGGAGATCCTGGATGGACTCTTCCAGATCCTGGGTGACAATGGCAAAGAGATTCGCAAAATGTGTGAGGTTGTTCTTGGAGAATTC
TTAAAAGAAATTAAGAAGAACCCCTCCAGTGTGAAGTTTGCTGAGATGGCCAACATCCTGGTGATCCACTGCCAGACAACAGATGACCTC
ATCCAGCTGACAGCCATGTGCTGGATGCGGGAGTTCATCCAGCTGGCGGGCCGCGTCATGCTGCCTTACTCCTCCGGGATCCTGACTGCT
GTCTTGCCCTGCTTGGCCTACGATGACCGCAAGAAAAGCATCAAAGAAGTGGCCAACGTGTGCAACCAGAGCCTGATGAAGCTGGTCACC
CCCGAGGACGACGAGCTGGATGAGCTGAGACCTGGGCAGAGGCAGGCAGAGCCCACCCCTGACGATGCCCTGCCAAAGCAGGAGGGCACA
GCCAGTGGAGGTCCAGATGGTTCCTGTGACTCCAGCTTCAGTAGCGGCATCAGTGTCTTCACTGCAGCCAGCACTGAAAGAGCCCCAGTG
ACCCTTCACCTCGACGGGATCGTGCAGGTCCTAAACTGCCACCTCAGTGACACGGCCATTGGGATGATGACCAGGATTGCAGTTCTCAAG
TGGCTCTACCACCTCTACATCAAAACTCCTCGGAAGATGTTCCGGCACACGGACAGCCTCTTTCCCATCCTACTGCAGACGTTATCGGAT
GAATCGGATGAGGTGATCCTGAAGGACCTGGAGGTGCTGGCAGAAATCGCTTCCTCCCCCGCAGGCCAGACGGATGACCCAGGCCCCCTC
GATGGCCCTGACCTCCAGGCCAGCCACTCAGAGCTCCAGGTGCCCACCCCTGGCAGAGCCGGCCTACTGAACACCTCTGGTACCAAAGGC
TTAGAATGTTCTCCTTCAACTCCCACCATGAATTCTTACTTTTATAAGTTCATGATCAACCTTCTCAAGAGATTCAGCAGCGAACGGAAG
CTCCTGGAGGTCAGAGGCCCTTTCATCATCAGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGG
GAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCG
AGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCC
TCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGT
GAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTT
TCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTA
CTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGG
GAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGC
AACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAG
GTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGA
TACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTT
GTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATAAAAGAACAT

>In-frame_ENST00000261776_ENST00000406884_TCGA-BT-A20V_VAC14_chr16_70765397_-_WWOX_chr16_79245504_length(amino acids)=605AA_start in transcript=261_stop in transcript=2078
MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLY
LKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVSFIPLL
RERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTT
DDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDELDELRPGQRQAEPTPDDALPKQ
EGTASGGPDGSCDSSFSSGISVFTAASTERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQT
LSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLQASHSELQVPTPGRAGLLNTSGTKGLECSPSTPTMNSYFYKFMINLLKRFSS

--------------------------------------------------------------
>In-frame_ENST00000261776_ENST00000539474_TCGA-BT-A20V-01A_VAC14_chr16_70732540_-_WWOX_chr16_79245505_length(transcript)=3157nt_BP=2097nt
TGTGACTCGAGTAACATGGCCGCTGTCTCGTGAGTCCCGCTAGTGCCGGGCGGGAGTTGTTAAGCGGCCAGGGTCAGGTGTGCTGGAGCG
GGGTCCGGGCCCGGGTTCCAGGGCGAGGCGGCGGAGCGTGGCAGGCAAGCCTAGAGCGGCGTGGTCCATGCGCCGGCGCCGGGGGCAGAG
CGGAGCCGCAGACTCCCCTGGCCCCGGCGCGGCCCCGGCAGCCGCGGGCTAAGGAGTCGCGAGGTTCCCCCAGCTGCCACCATGAACCCC
GAGAAGGATTTCGCGCCGCTCACGCCTAACATCGTGCGCGCCCTCAATGACAAGCTGTACGAAAAGCGGAAGGTGGCAGCGCTGGAGATC
GAGAAGCTGGTCCGGGAGTTCGTGGCCCAGAACAATACCGTGCAAATCAAGCATGTGATCCAGACCCTGTCCCAGGAGTTTGCCCTGTCT
CAGCACCCCCACAGCCGGAAAGGGGGCCTCATCGGCCTGGCCGCCTGCTCCATCGCACTGGGCAAGGACTCAGGGCTCTACCTGAAGGAG
CTGATCGAGCCAGTGCTGACCTGCTTCAATGATGCAGACAGCAGGCTGCGCTACTATGCCTGCGAGGCCCTCTACAACATCGTCAAGGTG
GCCCGGGGCGCTGTGCTGCCCCACTTCAACGTGCTCTTTGACGGGCTGAGCAAGCTGGCAGCCGACCCAGACCCCAATGTGAAAAGCGGA
TCTGAGCTCCTAGACCGCCTTTTAAAGGACATTGTGACTGAGAGCAACAAGTTTGACCTGGTGAGCTTCATCCCCTTGTTGCGAGAGAGG
ATTTACTCCAACAACCAGTATGCCCGGCAGTTCATCATCTCCTGGATCCTGGTTCTGGAGTCGGTGCCAGACATTAACCTGCTGGATTAC
CTGCCGGAGATCCTGGATGGACTCTTCCAGATCCTGGGTGACAATGGCAAAGAGATTCGCAAAATGTGTGAGGTTGTTCTTGGAGAATTC
TTAAAAGAAATTAAGAAGAACCCCTCCAGTGTGAAGTTTGCTGAGATGGCCAACATCCTGGTGATCCACTGCCAGACAACAGATGACCTC
ATCCAGCTGACAGCCATGTGCTGGATGCGGGAGTTCATCCAGCTGGCGGGCCGCGTCATGCTGCCTTACTCCTCCGGGATCCTGACTGCT
GTCTTGCCCTGCTTGGCCTACGATGACCGCAAGAAAAGCATCAAAGAAGTGGCCAACGTGTGCAACCAGAGCCTGATGAAGCTGGTCACC
CCCGAGGACGACGAGCTGGATGAGCTGAGACCTGGGCAGAGGCAGGCAGAGCCCACCCCTGACGATGCCCTGCCAAAGCAGGAGGGCACA
GCCAGTGGAGGTCCAGATGGTTCCTGTGACTCCAGCTTCAGTAGCGGCATCAGTGTCTTCACTGCAGCCAGCACTGAAAGAGCCCCAGTG
ACCCTTCACCTCGACGGGATCGTGCAGGTCCTAAACTGCCACCTCAGTGACACGGCCATTGGGATGATGACCAGGATTGCAGTTCTCAAG
TGGCTCTACCACCTCTACATCAAAACTCCTCGGAAGATGTTCCGGCACACGGACAGCCTCTTTCCCATCCTACTGCAGACGTTATCGGAT
GAATCGGATGAGGTGATCCTGAAGGACCTGGAGGTGCTGGCAGAAATCGCTTCCTCCCCCGCAGGCCAGACGGATGACCCAGGCCCCCTC
GATGGCCCTGACCTCCAGGCCAGCCACTCAGAGCTCCAGGTGCCCACCCCTGGCAGAGCCGGCCTACTGAACACCTCTGGTACCAAAGGC
TTAGAATGTTCTCCTTCAACTCCCACCATGAATTCTTACTTTTATAAGTTCATGATCAACCTTCTCAAGAGATTCAGCAGCGAACGGAAG
CTCCTGGAGGTCAGAGGCCCTTTCATCATCAGGCAGCTGTGCCTCCTGCTGAATGCGGAGAACATCTTCCACTCAATGGCAGACATCCTG
CTGCGGGAGGAGGACCTCAAGTTCGCCTCGACCATGGTCCACGCCCTCAACACCATCCTGCTGACCTCCACAGAGCTCTTCCAGCTAAGG
AACCAGCTGAAGGACCTGAAGACCCTGCAACAGGGAGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGG
ATGTACTTCAACAACTGCTGCCGCTGCATGCCCTCACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGG
CTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTAAGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACG
CAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCTCCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAA
ATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGGGGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGG
TGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTGTGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTT
ATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGCTACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGA
AAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGATCCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTG
CTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCAGTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGC
AAAGTACTTGTCATAGACTCCTTTGCTAATGCTATGCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCT
TGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAATACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTG
TCAATCACAGTCTCAGTTCTCTTGCTTTCACATTGTACTTAAACCTCCTGCTGTGCCTCGCATCCTATGCTTAATAAAAGAACATGCTTG

>In-frame_ENST00000261776_ENST00000539474_TCGA-BT-A20V-01A_VAC14_chr16_70732540_-_WWOX_chr16_79245505_length(amino acids)=674AA_start in transcript=261_stop in transcript=2285
MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLY
LKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVSFIPLL
RERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTT
DDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDELDELRPGQRQAEPTPDDALPKQ
EGTASGGPDGSCDSSFSSGISVFTAASTERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQT
LSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLQASHSELQVPTPGRAGLLNTSGTKGLECSPSTPTMNSYFYKFMINLLKRFSS
ERKLLEVRGPFIIRQLCLLLNAENIFHSMADILLREEDLKFASTMVHALNTILLTSTELFQLRNQLKDLKTLQQGAATTVYCAAVPELEG

--------------------------------------------------------------
>In-frame_ENST00000536184_ENST00000539474_TCGA-BT-A20V-01A_VAC14_chr16_70732540_-_WWOX_chr16_79245505_length(transcript)=2222nt_BP=1162nt
GAACGGCCTGCCTACTGTTTGCGCTTTGTGGTCTGGCCTCTTTGTTACCAAATGCTCTGGGGTTGCTTTGGGGCTGGGGGTGGGGAGGAA
TCTTCTCCAGCCTGGCCCCAGAGCCATGGCTGGCGTTCAGGGGCATTTGGGAAGCTGGGCCCAGGTCATGCGGAGCGGAGGCTGAGTCCA
GCGACCTAGGAGGAGATGGAGGTGTTTCAGGCCTCCCACCAAGAAATGTGGCTCACGTCACTGAGCACCCAAGACCTCGGGGCCTCCGAC
GCCGTGTTGGAACTGTGGTGATGCTTCCCTGGAGACGGGATGCGGCGTCAGGCACTGGAGCTTAGCCCCAGACGGAAGGTGGTGTGGGCA
GGGGTGCCACGCTGCCGCCAGCCCAGCACTCAGGAAGCGCAGTGCTGCACACCACCCTCTCACCAGCCACCCCGCTCATGCCCCATCCTG
CCTGCATCATGCTGTTTTGGGGAAGCTCCCGAATCCCTGGGACTCCAGCTGGGAAGCATTGCCCAGGTGCCCTTCCCCTGCAGGCCAGGC
CTCCAAGGGCACGTGGAAAAGCAGCGCGGATTCCTCCAAGCCTGTCCTCACCACCCACTTCTCACTGCTCGTGTCATCCGGCCCAGGGAC
CCTGAGGAATCTGCTTTTCTTCATCCTCTGGGTTCCCTTTTTGCCTTTTGTATAACAGGGAGGCTCCTCTTCACAAAGTCCGATCCTTAG
CCCTGAACGACTCTTAACTAGACAAGAGATGGGAAAGGGGTCATGGCCCAGGGACCAGCGAGCCCTAAGTGACTCTGGCCGTAAGTGACT
CTGCGACCTTAGTCAAGTCACTTCACCAGAGTTTCACCATCCGTACAGTGAAGAAAAAACTCAGGGTCATAACGCTGATCCCACACGGAT
CTGTGCTCCAGGCCGCAGGGTACAGCCCGAACAGTGCAAATCCCTGACCTCGGGGGCTTCCAGGAGGAGGAGTGGGGCAGTAAACAGGCA
GCTGTGCCTCCTGCTGAATGCGGAGAACATCTTCCACTCAATGGCAGACATCCTGCTGCGGGAGGAGGACCTCAAGTTCGCCTCGACCAT
GGTCCACGCCCTCAACACCATCCTGCTGACCTCCACAGAGCTCTTCCAGCTAAGGAACCAGCTGAAGGACCTGAAGACCCTGCAACAGGG
AGCTGCCACCACCGTGTACTGTGCTGCTGTCCCAGAACTGGAGGGTCTGGGAGGGATGTACTTCAACAACTGCTGCCGCTGCATGCCCTC
ACCAGAAGCTCAGAGCGAAGAGACGGCCCGGACCCTGTGGGCGCTCAGCGAGAGGCTGATCCAAGAACGGCTTGGCAGCCAGTCCGGCTA
AGTGGAGCTCAGAGCGGATGGGCACACACACCCGCCCTGTGTGTGTCCCCTCACGCAAGTGCCAGGGCTGGGCCCCTTCCAAATGTCCCT
CCAACACAGATCCGCAAGAGTAAAGGAAATAAGAGCAGTCACAACAGAGTGAAAAATCTTAAGTACCAATGGGAAGCAGGGAATTCCTGG
GGTAAAGTATCACTTTTCTGGGGCTGGGCTAGGCATAGGTCTCTTTGCTTTCTGGTGGTGGCCTGTTTGAAAGTAAAAACCTGCTTGGTG
TGTAGGTTCCGTATCTCCCTGGAGAAGCACCAGCAATTCTCTTTCTTTTACTGTTATAGAATAGCCTGAGGTCCCCTCGTCCCATCCAGC
TACCACCACGGCCACCACTGCAGCCGGGGGCTGGCCTTCTCCTACTTAGGGAAGAAAAAGCAAGTGTTCACTGCTCCTTGCTGCATTGAT
CCAGGAGATAATTGTTTCATTCATCCTGACCAAGACTGAGCCAGCTTAGCAACTGCTGGGGAGACAAATCTCAGAACCTTGTCCCAGCCA
GTGAGGATGACAGTGACACCCAGAGGGAGTAGAATACGCAGAACTACCAGGTGGCAAAGTACTTGTCATAGACTCCTTTGCTAATGCTAT
GCAAAAAATTCTTTAGAGATTATAACAAATTTTTCAAATCATTCCTTAGATACCTTGAAAGGCAGGAAGGGAAGCGTATATACTTAAGAA
TACACAGGATATTTTGGGGGGCAGAGAATAAAACGTTAGTTAATCCCTTTGTCTGTCAATCACAGTCTCAGTTCTCTTGCTTTCACATTG

>In-frame_ENST00000536184_ENST00000539474_TCGA-BT-A20V-01A_VAC14_chr16_70732540_-_WWOX_chr16_79245505_length(amino acids)=262AA_start in transcript=900_stop in transcript=1688
MCSRPQGTARTVQIPDLGGFQEEEWGSKQAAVPPAECGEHLPLNGRHPAAGGGPQVRLDHGPRPQHHPADLHRALPAKEPAEGPEDPATG
SCHHRVLCCCPRTGGSGRDVLQQLLPLHALTRSSERRDGPDPVGAQREADPRTAWQPVRLSGAQSGWAHTPALCVSPHASARAGPLPNVP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for VAC14-WWOX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneWWOXchr16:70732540chr16:79245505ENST0000035586006125_4140190.0MAPT
TgeneWWOXchr16:70732540chr16:79245505ENST00000408984010125_4140311.6666666666667MAPT
TgeneWWOXchr16:70732540chr16:79245505ENST0000056981801125_414037.0MAPT
TgeneWWOXchr16:70765397chr16:79245504ENST0000035586006125_4140190.0MAPT
TgeneWWOXchr16:70765397chr16:79245504ENST00000408984010125_4140311.6666666666667MAPT
TgeneWWOXchr16:70765397chr16:79245504ENST0000056981801125_414037.0MAPT
TgeneWWOXchr16:70765398chr16:79245505ENST0000035586006125_4140190.0MAPT
TgeneWWOXchr16:70765398chr16:79245505ENST00000408984010125_4140311.6666666666667MAPT
TgeneWWOXchr16:70765398chr16:79245505ENST0000056981801125_414037.0MAPT


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneWWOXchr16:70732540chr16:79245505ENST0000040265535125_414136.33333333333334312.0MAPT
TgeneWWOXchr16:70732540chr16:79245505ENST0000040688446125_414172.0235.0MAPT
TgeneWWOXchr16:70732540chr16:79245505ENST0000056678079125_414352.0415.0MAPT
TgeneWWOXchr16:70765397chr16:79245504ENST0000040265535125_414136.33333333333334312.0MAPT
TgeneWWOXchr16:70765397chr16:79245504ENST0000040688446125_414172.0235.0MAPT
TgeneWWOXchr16:70765397chr16:79245504ENST0000056678079125_414352.0415.0MAPT
TgeneWWOXchr16:70765398chr16:79245505ENST0000040265535125_414136.33333333333334312.0MAPT
TgeneWWOXchr16:70765398chr16:79245505ENST0000040688446125_414172.0235.0MAPT
TgeneWWOXchr16:70765398chr16:79245505ENST0000056678079125_414352.0415.0MAPT


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VAC14-WWOX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VAC14-WWOX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVAC14C4310743STRIATONIGRAL DEGENERATION, CHILDHOOD-ONSET2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneVAC14C1857663Yunis Varon syndrome1ORPHANET
TgeneWWOXC0279626Squamous cell carcinoma of esophagus3CTD_human;ORPHANET
TgeneWWOXC3280452SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 122GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneWWOXC4015519EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 282CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneWWOXC0002395Alzheimer's Disease1CTD_human
TgeneWWOXC0006142Malignant neoplasm of breast1CTD_human
TgeneWWOXC0007137Squamous cell carcinoma1CTD_human
TgeneWWOXC0011265Presenile dementia1CTD_human
TgeneWWOXC0024623Malignant neoplasm of stomach1CTD_human
TgeneWWOXC0038356Stomach Neoplasms1CTD_human
TgeneWWOXC0042076Urologic Neoplasms1CTD_human
TgeneWWOXC0087031Juvenile-Onset Still Disease1CTD_human
TgeneWWOXC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneWWOXC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneWWOXC0546126Acute Confusional Senile Dementia1CTD_human
TgeneWWOXC0678222Breast Carcinoma1CTD_human
TgeneWWOXC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneWWOXC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneWWOXC0751571Cancer of Urinary Tract1CTD_human
TgeneWWOXC1257931Mammary Neoplasms, Human1CTD_human
TgeneWWOXC1458155Mammary Neoplasms1CTD_human
TgeneWWOXC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneWWOXC3495559Juvenile arthritis1CTD_human
TgeneWWOXC3714758Juvenile psoriatic arthritis1CTD_human
TgeneWWOXC451074446,XY partial gonadal dysgenesis1ORPHANET
TgeneWWOXC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneWWOXC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneWWOXC4704874Mammary Carcinoma, Human1CTD_human