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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VAPA-GDAP2 (FusionGDB2 ID:97210)

Fusion Gene Summary for VAPA-GDAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: VAPA-GDAP2
Fusion gene ID: 97210
HgeneTgene
Gene symbol

VAPA

GDAP2

Gene ID

9218

54834

Gene nameVAMP associated protein Aganglioside induced differentiation associated protein 2
SynonymsVAP-33|VAP-A|VAP33|hVAP-33MACROD3|SCAR27
Cytomap

18p11.22

1p12

Type of geneprotein-codingprotein-coding
Descriptionvesicle-associated membrane protein-associated protein A33 kDa VAMP-associated proteinVAMP (vesicle-associated membrane protein)-associated protein A, 33kDaVAMP-Aepididymis secretory sperm binding proteinganglioside-induced differentiation-associated protein 2
Modification date2020032720200313
UniProtAcc.

Q9NXN4

Ensembl transtripts involved in fusion geneENST00000400000, ENST00000340541, 
ENST00000584796, 		ENST00000369443, 
ENST00000369442, ENST00000464026, 
Fusion gene scores* DoF score9 X 4 X 7=2524 X 3 X 2=24
# samples 104
** MAII scorelog2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VAPA [Title/Abstract] AND GDAP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVAPA(9914332)-GDAP2(118413238), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVAPA

GO:0044791

positive regulation by host of viral release from host cell

19515777

HgeneVAPA

GO:0044828

negative regulation by host of viral genome replication

19515777

HgeneVAPA

GO:0044829

positive regulation by host of viral genome replication

19515777


check buttonFusion gene breakpoints across VAPA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GDAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8525-01AVAPAchr18

9914332

+GDAP2chr1

118413238

-


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Fusion Gene ORF analysis for VAPA-GDAP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000400000ENST00000369443VAPAchr18

9914332

+GDAP2chr1

118413238

-
5CDS-intronENST00000400000ENST00000369442VAPAchr18

9914332

+GDAP2chr1

118413238

-
5CDS-intronENST00000400000ENST00000464026VAPAchr18

9914332

+GDAP2chr1

118413238

-
In-frameENST00000340541ENST00000369443VAPAchr18

9914332

+GDAP2chr1

118413238

-
5CDS-intronENST00000340541ENST00000369442VAPAchr18

9914332

+GDAP2chr1

118413238

-
5CDS-intronENST00000340541ENST00000464026VAPAchr18

9914332

+GDAP2chr1

118413238

-
intron-3CDSENST00000584796ENST00000369443VAPAchr18

9914332

+GDAP2chr1

118413238

-
intron-intronENST00000584796ENST00000369442VAPAchr18

9914332

+GDAP2chr1

118413238

-
intron-intronENST00000584796ENST00000464026VAPAchr18

9914332

+GDAP2chr1

118413238

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400000VAPAchr189914332+ENST00000369443GDAP2chr1118413238-746633455381108
ENST00000340541VAPAchr189914332+ENST00000369443GDAP2chr1118413238-74062744321105

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400000ENST00000369443VAPAchr189914332+GDAP2chr1118413238-0.85689340.14310655
ENST00000340541ENST00000369443VAPAchr189914332+GDAP2chr1118413238-0.853287040.14671294

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Fusion Genomic Features for VAPA-GDAP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VAPA-GDAP2


check button Go to

FGviewer for the breakpoints of chr18:9914332-chr1:118413238

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GDAP2

Q9NXN4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGDAP2chr18:9914332chr1:118413238ENST00000369442013333_4810497.0DomainNote=CRAL-TRIO
TgeneGDAP2chr18:9914332chr1:118413238ENST0000036944201343_2230497.0DomainMacro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVAPAchr18:9914332chr1:118413238ENST00000340541+17169_20526.333333333333332295.0Coiled coilOntology_term=ECO:0000255
HgeneVAPAchr18:9914332chr1:118413238ENST00000400000+16169_20526.333333333333332250.0Coiled coilOntology_term=ECO:0000255
HgeneVAPAchr18:9914332chr1:118413238ENST00000340541+1714_13126.333333333333332295.0DomainMSP
HgeneVAPAchr18:9914332chr1:118413238ENST00000400000+1614_13126.333333333333332250.0DomainMSP
HgeneVAPAchr18:9914332chr1:118413238ENST00000340541+172_22726.333333333333332295.0Topological domainCytoplasmic
HgeneVAPAchr18:9914332chr1:118413238ENST00000400000+162_22726.333333333333332250.0Topological domainCytoplasmic
HgeneVAPAchr18:9914332chr1:118413238ENST00000340541+17228_24826.333333333333332295.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVAPAchr18:9914332chr1:118413238ENST00000400000+16228_24826.333333333333332250.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneGDAP2chr18:9914332chr1:118413238ENST000003694431214333_481482.0498.0DomainNote=CRAL-TRIO
TgeneGDAP2chr18:9914332chr1:118413238ENST00000369443121443_223482.0498.0DomainMacro


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Fusion Gene Sequence for VAPA-GDAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000400000_ENST00000369443_TCGA-CD-8525-01A_VAPA_chr18_9914332_+_GDAP2_chr1_118413238_length(transcript)=7466nt_BP=334nt
TCACGTGGGTCGCCGAGGCTCGCAAGTGCGCGTGGCCGTGGCGGCTGGTGTGGGGTTGAGTCAGTTGTGGGACCCGGAGCTGCTGACCCA
GCGGGTGGCCCACCGAACCGGTGACACAGCGGCAGGCGTTAGGGCTCGGGAGCCGCGAGCCTGGCCTCGTCCTAGAGCTCGGCCGAGCCG
TCGCCGCCGTCGTCCCCCGCCCCCAGTCAGCAAACCGCCGCCGCGGGCGCGCCCCCGCTCTGCGCTGTCTCTCCGATGGCGTCCGCCTCA
GGGGCCATGGCGAAGCACGAGCAGATCCTGGTCCTCGATCCGCCCACAGACCTCAAATTCAAAGGAAAACGGGCCTTACTATACATCATA
TCCCCCATCACCAGATTTGTGACCTGCCATCTTTCAGTGCTTCTTGGTTCCCAGGATGCCACTTCCTCCACGAATAGCTACCTGTTGAAG
TGATATTCATTGTTGCTGTACAGATCCAGAGAGCCTTTTGTCCCCACCTCTCTGGTATTTTTTTATTGACTGTATATTTTCTGGCACATA
AGCAATCTAAAAATGGTAGGCCATTCTGAACTGCACACATTTTAAATTTGTATATTTATATGAAATGGAAATGTTCATTTTTAGATTGTT
AATAGAAATTGGGGAGCAACTTTTGAGTATCTTTAGTTTCCTGAAGGACACCGAATTCTCCATTAGATAAACCACCAAGACTGTTCACAT
CATCTCTCTAACATTGCACGCTTCCTTTGTGTACTTAAGTGATTCTCGAAATATACAGAACCAATGTATGCTAACCAGATGCATTGTTTG
CTTCAGATCCATGGTGTTAATACCATGTATATTTTATAAAGATAATTTGGCTGTGTTAAAAGAGAATTACCTGAGTCCAAGAATGTGGAA
ATGTATCTGACAAAAAACATCAAAATCATTAGCAAAACATAGGACTTAGAATGTTAATGTACAAGTTAAGACTAAAGTTTAAGGACTAAG
GTTCCTTGGATTATATGACTTGTTAAGATTGCCACAGTTCCGATCTCAACAGTGTGGGGTGAAACAAGAAGACTGTATCTTCAGCCTTTT
TCCTATAATCATGGATGATTTGGTCTTATTCAAAAGGACCGCACATATTAGTACTCTTAAGAGCATCTTCCAAGACTCCAGCAGTGAGCA
TTTAGAGAGTGTGTTGTCTTCCAGAGTCATGAATGATTTTGTTTAGCTATCAGGTCTACTACCTCTAAGGACATTTCATAGCAGCATCTC
TTGAGTTGCCTGCATCAGTGTGGAGGAAGTGTGTCACAGTGAACAAATCCAGGGAGCTGATAATTGGCAAAAGACCACTTTTACCACTCA
GGCTCTATTTGTGCCTTAGCTTGGTTATGAGTAAAAATTAGAATTATGCTGCCTACCTCACAGAGGTATCATGAAGATAGCATTTAGAAA
GGGCTTTGTTGTGGTGGGGTATCTTCAGTTAGTTTTTAAATGGGAATAAATATATATGAGGGAATGCTACACAGCACTCCTCTTGTCCTT
GATACCATTTGAGTGATTTTTCTTTTTGTGTGGCAATACCTGTTAGTGTAAAATTCCAACCCTGATGACCTCCTTCCTCTTTTGTCCAGA
ATCTCTTCTGGCCTGCTCATCCCCTGATGCTATACTTCAATAAGAGGCATCTGTTGGCCATTTTAAACATTTCTTCTTGAATTAAGGTCA
AACCATTATTATTCCCATCTGGGTAGCTTTGTACTTTTTTTGATTCCTACAGCCACCTCCCCACAGCCCCATCTTCCTCACCCCATCACG
TACATTGGCAGTTCAGAGAAAAAAAAAAGCAGAACCTTTCTGTTCTATCATGTGCTCCAGATCAGTGCTTCCAAGGGTCCCATTCTTTTC
TGCCCAAACTAATTCTTCATTGGAGATCAAAGAAACATATTCTCTTCATTTATGATAGGGAAATGCCCCTATAGTGCATTAAATTCATCC
TGTATTTTCCCATATAAACAAGAAGAGACTTTACATTTTTTAGATAAAGGTTCTTATCTTTTGCATGTATTGAACACATTTTCTTTGTGT
CAGACCTCAAAATTACTTGATCCTTATATATACATCTATGTTAAGATTTTCTCTTATGTCCCCTAGGTCATCACATCCAGGCAGCCAGTC
AGATGTCGGATGTTAAGCTTTCTCTCAAACAGTACTTTTTTTTTAACCCCTTGGGCACTGTACCTTAAAAGTCTGCAACTTTAACTTCAT
CTTCTACAGTCAATCGTGAGATCATATTTGAGGTATCTTCTTCACAAGGAGCAGCTATGAAAGTCTGCCAACTTTTCTTTGTTAAAGGGG
AACTTGGCTACCTCAAGAACCTGGCCCAAACCATTTTCTGTAGAGATAATAGAGGCCGTAAGCTACTTTGCCAATTTGAAAGGAAGCAAA
TTTATATATACAATTTCTTACAGGCAATGATTTTGAAAGGATGTTCCTTTGCTATATTCATACCAGTATATTAATGTTTAGTAACACAAG
CAGGATTCTACATATGCTGAGATTTTAGTACAATTGATGTCCTAGGGTATAAAGGTGATACAGAACTATATACATATCAACTGTGTTTTA
TAATTCAATGATGACTAAAGAAAGATAAGGACCACTCTTCTCACTGAAACTAAATTTGATGTGGGACCAAGTTCATGCTTTTATAGATGT
CTAAAGTGTTATAGAATGAAGTTGCTTCAAAGTACCAAATCCTAGAGGAGAAATATAATGACCTTGATATTGAAATGATTAAGCAACATT
TGGTATACCAATCTGCCTTTGTGAAAAGGTTTAGCCTGAATAATACATGCCATTTTCAAGGACATATTAGAGGATAAAGGGGATACTGGA
TGGAGATGACCACCAGCATCTGATGTTAATTCAAAGCACCACCAAGTCTTTAATTTAATTAAACTTTGGTCATGCCAAATGCTAATTGAA
TTGTTGAAGACACAAGTTATAAAATATTAATTTATTAATCATGCAAGGCATAATATGATTTTTAAAACAAGTACACTTCTTGCTTCCACG
TGTATTTGGGTTCTTAATTCATCTATATCCAAGTTTCTTGATAGTGAAAATTACCTCTTAAAAAAGGTTCAGCCTTTATTAGACTCGTGA
GGGCAAATGGTACATATTTTAAAGACGTTTTCTCCTTTAATGTATATTATGTTTCATTGGCGGATGCTTTATATTTCCTTTTTCTTTTTC
TTTTTTTTTTGGAGACAGTCTTACTCTGTCACCCAAGCTGGAGTGCAATGGTGTGATCTCGGCTCACTGCAGCCTCGGCCTCCCAGGTTT
AAGTGGTTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGACTACAGGTGCCTGCCACCATGCCTGGCTAATTTTTTTTTTTTTTTTTTTTTT
TTTCAGTAGAGACAGGGTTTCACCATGTTGGCCAGACTGGTCTCAAACTCCTGACCTCAAGTGATCTTCCTGCCTCGGCCTCCCAAAGTG
TTGGGCTTACCAGTATGAGCCACCGTGCCCATCCTGTATTTCCTTTTTCAAAGGAATACATCTGCAGTATTTTGAGAGTAATTAGCAGAG
GGTTTTTTGAGTATTTTTGGTAGGAAAAATAGATGTAGTTTTTTAATCAAATTTCTGAAATTGAAAATATCACTTCTTTTTAAAGAGGGA
TAAGTATAGTCACTCTAGTAGAAAAACATGGCTTGCCTATTTCCTCTTCTTTTCTGTTTGCTTGGATATTGTTTAATGAATTCAAACTGT
AGGTTTAGTCTTGTCTTTATAACAGTTAATGGAGAAGTGATAAAATTAAGTATTCAGCATAAACTAAAGATCACTCTTTGTATTTCCCCG
ATACATTGACAGTATGTATGTATATAGAGTTTAAATTGCTTAATATATGCACAGAAATGATTAGAATTTGAAGTACTATATAGAGGAGAG
TTACATGGTTCTAGTGGCAGTGGATTGATTGTATTAAGGACCAAAAGAACTGCAGGATAATATAAAAACACCTTGAAAACTGGAGTTAGT
TAGGTTTCTTTTTCTTTTTCTTTTTTTTTTTTAAAGGGCCTTACTGTACTTTTTTTTTTTTTTTGGTCACCCAGGCTGGAGTGCAATGGC
ACGATCTCGGCTCACTGTAATCTCTGTCTCCTGGGTTCAAGAGATTCTCCTGTCTCAGCCTCCCCAGTAAGTGAGATTATAGACATGCAC
CACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGCTCTCGAATTCCTGACCTCAGGTGAT
CTGCCCACCTTGGCTTCTCAAAGTGCCAGATTACAGGCATAAGCCACTGTGCCTGGCCAGGTTTCTGATTATAGTTTTCTTAAGTTGTAA
TCATCATAATTAACGTGCGCTAGAGTGTTTTAACTGTGCTGGCACTAATGCTTCTTGGCATATAATTAACTCTTGTTTTGCAAAAAGACC
ATGAAGAATGAAAGGAGGGCTTTACCTTACCTTAGTCATTTTGGGTGAATACCGTAAACTGGGTGGCGTAACAAAACACATTTATTTCTC
ACAGTTGGAGGCTGAGAAACCCCAAGATCAAAGTGCCATCCAGCGCAATTCCTGATGAGGGCCCTCTTCTGGCTTCTTGCTGTATTCTCA
CTTGGCAGAGAGAGAGAGACATCGTTACTTTCCTGTCTCTTCTTATAAGGGCACTAATCTCATTCATGAGGGCTCCACCCTCATGACATG
ATTACCACCCAGAGGCCCCACCTCCAAATGCCATCACTTTGTATGTTAGGGCTTCAACATATGAATTTGCAGACGAGGAGGAGAACATAA
GCATTCAGTTCATAACATACCTATAATCTAGGTCATATCATAAACCCAGAGATGATAAGGATTGCCTGGTAGGCCTAACCATATATACAT
ATACATGCATGCACACACACATATATGCATAATCTGCCTTGTTTTACATTCTTTGAGTCGGACTTCTGTGGTCCATATGTAGAGAACATA
GAGCAATAAATAACCTAGTTCAATCTTTGAGTCTTACTGAACTAGTCCTTAAACAGATGGTATCAAGATCATTTTAGATATTAGTGACTC
TCTTGTATATTAGTTATTTTTTACACTTTTAAGAACAGCATCTTTGAATCTTTTCAAGTACAGTATGCCTTAAATGTATAGGACCACTGA
GTTCAGGAAGAAAAGCATAGGTATTCTGTAGGTGAATTACACTAACAAAATCACAACTGCAGAATGTGATCTGATACTTTTGTTGGACAG
TAAAGCTAATACATTTTATATACACAGTCATACCTTTTTTTTTTGTAATGTGTTTCGTTAACGTAAGCACACAGTCATCACAGACTGAGA
CAGGACTTTGTTAGACCAGATCTTGTGAGCTAAATATTTAAGAGCTTAACATATATAAATGATTTTAATTGGTATTGGGCGAAGGAAACC
TAAAAATGCTTAAATTGACAGATCTTACAATTTGCTTACTGAAAATTCAGAAAGCTTTTATGAAAACTTTGTATTTTAAAATATTTTTTG
CTCATTCTGAATTAGAAGTTAGATCCCTTTTAAAGAGGGTCTCACTCTATACAAATATAGCCTATGAAGAATCAATAGTGAAATAATAGT
GTTTATATTGAACCCCAGGATGGGACATTATTTTTTGACCATTTACATGAGGTCTTTCTCTAATTACCAAAGTTAACCTTAAGAGTAGTT
AAAAACTCAGTGAATTTTAGTCAACATTCTCTGTGGAGACCTGGACTAGTGTTTCCCAAACTTTCATGTGCATGTATCAAATCAGCTGAG
GATATTATTAAATGGAGATTCAGATTCAATAGTTCTGGGGTGGCCTCTGGGATTATCAGTTTCTAACAAGCTCTTAGGTGTTATCAATTC
TCCTGGTCCCCAGACCATAGTTAGAGTAAAAGAGTATAGACTGCATTTAGCTTCCAGATTTTCTCTTTCAAGGAAAGGAGACAGAACTGT
CATTGTAATTCTTCCTGTGGTCCAGGCACTCTAACGTTCATCGTCTCTTCTAATGCTCTTACAAATCCTGTGAGGTTGGTGATAATAGAA
GTTACCTCCTGAAGACGACATTCACAAGCAGGACCGACCGTGTAGACCAGTTTTCTCAAACTGAATAATGTACTTCACTTTTTAATAAGG
AAAAAAATCTCTTAGCTCCTCAGTTTTTGCTTAATTTATATTTATTATAATGTTATCTAAATATATATAAACATAAAACTAGGTATAAAT
GCTTTATGTTTATATGTCTTGCACAAGTATAAAACCAAAACAAGTTTATGGGTTAACACAAGCAAAACTATAAAACTAATAAAATTTAAA
ATAGTATTAAATAGTGATGTTTTGACAAAATGAAATTGTCACTTGTAATGTGATTATGGTACTGAGTGCTACAGTACAGGCTCTTTTCAG
TTCAACAGGCATGTACTGCCATGTACTATGTGATGACCCAATTCACCCTGTTTTCTCCTATTCAGACTATTACTTTAATTTGTTCAGCAC
ATAGTGATGTTATTTGGTCCTCATCTAGCCTGAATCCATCATTCCCCTATTAAAACAGCCTCTGTTCTCCATAAGCCTTCCACCACTAAT
GTAGAACTGGGCCTTAACAGGGAAGTCAATACAAATACAAACCTAAGCACTGAGATGGTTCTGCCAATATTTGGTTTTAATACAATTATC
CAAATAATTCAGAGCATGAATATTATTTTAAAATGTTTCATCAACATGAATAATGCATAATTCTCATAGTAAGTTCATGGGCACTTTCCT
ACACCCAACACATATATACTCCACAAGGATTTTGCATGGACCCCAGTTTAAGAAGCAACAATTTAGTGGTCAGTAGCATTGGCGCTTTGG
CTTCTGACACACTCAGACCTTGGGCCTGTTTCTCAACTTTTTCTGAACCTCAGTGTTTTTGTGTATTCAACAGGGATAATATTAATTGAA
TAATTAGGAGGAACAAATGCAATAATGTACATAAAGCATGCATAGTAGTGTTTATAAATAGCAGCCACCACTGCTTTGATTAGAAATAAT
AACAGCTAACATTTGAGGATTTACTGTGTGCCTTGAACGCTGCTAAGCTCTTTATATATATTACATATTGAGTGGTAGAATCAGGATTCA
AATCCAGATCTGACTCCAAAGCGCATGCTTTTATAAAACATAATTTAAATATAGAATATCAATGTAAATTGCTTATTTAGAAAGTTTATT
TTCTTATATTTTCTCAAAAATATTTATTGTCAAATCAGTGATTCTGTAGAGGGGTAAATAGCTAAATTTCCTTTTAAAAATTGTATGATG

>In-frame_ENST00000400000_ENST00000369443_TCGA-CD-8525-01A_VAPA_chr18_9914332_+_GDAP2_chr1_118413238_length(amino acids)=108AA_start in transcript=55_stop in transcript=381
MSQLWDPELLTQRVAHRTGDTAAGVRAREPRAWPRPRARPSRRRRRPPPPVSKPPPRARPRSALSLRWRPPQGPWRSTSRSWSSIRPQTS

--------------------------------------------------------------
>In-frame_ENST00000340541_ENST00000369443_TCGA-CD-8525-01A_VAPA_chr18_9914332_+_GDAP2_chr1_118413238_length(transcript)=7406nt_BP=274nt
TCAGTTGTGGGACCCGGAGCTGCTGACCCAGCGGGTGGCCCACCGAACCGGTGACACAGCGGCAGGCGTTAGGGCTCGGGAGCCGCGAGC
CTGGCCTCGTCCTAGAGCTCGGCCGAGCCGTCGCCGCCGTCGTCCCCCGCCCCCAGTCAGCAAACCGCCGCCGCGGGCGCGCCCCCGCTC
TGCGCTGTCTCTCCGATGGCGTCCGCCTCAGGGGCCATGGCGAAGCACGAGCAGATCCTGGTCCTCGATCCGCCCACAGACCTCAAATTC
AAAGGAAAACGGGCCTTACTATACATCATATCCCCCATCACCAGATTTGTGACCTGCCATCTTTCAGTGCTTCTTGGTTCCCAGGATGCC
ACTTCCTCCACGAATAGCTACCTGTTGAAGTGATATTCATTGTTGCTGTACAGATCCAGAGAGCCTTTTGTCCCCACCTCTCTGGTATTT
TTTTATTGACTGTATATTTTCTGGCACATAAGCAATCTAAAAATGGTAGGCCATTCTGAACTGCACACATTTTAAATTTGTATATTTATA
TGAAATGGAAATGTTCATTTTTAGATTGTTAATAGAAATTGGGGAGCAACTTTTGAGTATCTTTAGTTTCCTGAAGGACACCGAATTCTC
CATTAGATAAACCACCAAGACTGTTCACATCATCTCTCTAACATTGCACGCTTCCTTTGTGTACTTAAGTGATTCTCGAAATATACAGAA
CCAATGTATGCTAACCAGATGCATTGTTTGCTTCAGATCCATGGTGTTAATACCATGTATATTTTATAAAGATAATTTGGCTGTGTTAAA
AGAGAATTACCTGAGTCCAAGAATGTGGAAATGTATCTGACAAAAAACATCAAAATCATTAGCAAAACATAGGACTTAGAATGTTAATGT
ACAAGTTAAGACTAAAGTTTAAGGACTAAGGTTCCTTGGATTATATGACTTGTTAAGATTGCCACAGTTCCGATCTCAACAGTGTGGGGT
GAAACAAGAAGACTGTATCTTCAGCCTTTTTCCTATAATCATGGATGATTTGGTCTTATTCAAAAGGACCGCACATATTAGTACTCTTAA
GAGCATCTTCCAAGACTCCAGCAGTGAGCATTTAGAGAGTGTGTTGTCTTCCAGAGTCATGAATGATTTTGTTTAGCTATCAGGTCTACT
ACCTCTAAGGACATTTCATAGCAGCATCTCTTGAGTTGCCTGCATCAGTGTGGAGGAAGTGTGTCACAGTGAACAAATCCAGGGAGCTGA
TAATTGGCAAAAGACCACTTTTACCACTCAGGCTCTATTTGTGCCTTAGCTTGGTTATGAGTAAAAATTAGAATTATGCTGCCTACCTCA
CAGAGGTATCATGAAGATAGCATTTAGAAAGGGCTTTGTTGTGGTGGGGTATCTTCAGTTAGTTTTTAAATGGGAATAAATATATATGAG
GGAATGCTACACAGCACTCCTCTTGTCCTTGATACCATTTGAGTGATTTTTCTTTTTGTGTGGCAATACCTGTTAGTGTAAAATTCCAAC
CCTGATGACCTCCTTCCTCTTTTGTCCAGAATCTCTTCTGGCCTGCTCATCCCCTGATGCTATACTTCAATAAGAGGCATCTGTTGGCCA
TTTTAAACATTTCTTCTTGAATTAAGGTCAAACCATTATTATTCCCATCTGGGTAGCTTTGTACTTTTTTTGATTCCTACAGCCACCTCC
CCACAGCCCCATCTTCCTCACCCCATCACGTACATTGGCAGTTCAGAGAAAAAAAAAAGCAGAACCTTTCTGTTCTATCATGTGCTCCAG
ATCAGTGCTTCCAAGGGTCCCATTCTTTTCTGCCCAAACTAATTCTTCATTGGAGATCAAAGAAACATATTCTCTTCATTTATGATAGGG
AAATGCCCCTATAGTGCATTAAATTCATCCTGTATTTTCCCATATAAACAAGAAGAGACTTTACATTTTTTAGATAAAGGTTCTTATCTT
TTGCATGTATTGAACACATTTTCTTTGTGTCAGACCTCAAAATTACTTGATCCTTATATATACATCTATGTTAAGATTTTCTCTTATGTC
CCCTAGGTCATCACATCCAGGCAGCCAGTCAGATGTCGGATGTTAAGCTTTCTCTCAAACAGTACTTTTTTTTTAACCCCTTGGGCACTG
TACCTTAAAAGTCTGCAACTTTAACTTCATCTTCTACAGTCAATCGTGAGATCATATTTGAGGTATCTTCTTCACAAGGAGCAGCTATGA
AAGTCTGCCAACTTTTCTTTGTTAAAGGGGAACTTGGCTACCTCAAGAACCTGGCCCAAACCATTTTCTGTAGAGATAATAGAGGCCGTA
AGCTACTTTGCCAATTTGAAAGGAAGCAAATTTATATATACAATTTCTTACAGGCAATGATTTTGAAAGGATGTTCCTTTGCTATATTCA
TACCAGTATATTAATGTTTAGTAACACAAGCAGGATTCTACATATGCTGAGATTTTAGTACAATTGATGTCCTAGGGTATAAAGGTGATA
CAGAACTATATACATATCAACTGTGTTTTATAATTCAATGATGACTAAAGAAAGATAAGGACCACTCTTCTCACTGAAACTAAATTTGAT
GTGGGACCAAGTTCATGCTTTTATAGATGTCTAAAGTGTTATAGAATGAAGTTGCTTCAAAGTACCAAATCCTAGAGGAGAAATATAATG
ACCTTGATATTGAAATGATTAAGCAACATTTGGTATACCAATCTGCCTTTGTGAAAAGGTTTAGCCTGAATAATACATGCCATTTTCAAG
GACATATTAGAGGATAAAGGGGATACTGGATGGAGATGACCACCAGCATCTGATGTTAATTCAAAGCACCACCAAGTCTTTAATTTAATT
AAACTTTGGTCATGCCAAATGCTAATTGAATTGTTGAAGACACAAGTTATAAAATATTAATTTATTAATCATGCAAGGCATAATATGATT
TTTAAAACAAGTACACTTCTTGCTTCCACGTGTATTTGGGTTCTTAATTCATCTATATCCAAGTTTCTTGATAGTGAAAATTACCTCTTA
AAAAAGGTTCAGCCTTTATTAGACTCGTGAGGGCAAATGGTACATATTTTAAAGACGTTTTCTCCTTTAATGTATATTATGTTTCATTGG
CGGATGCTTTATATTTCCTTTTTCTTTTTCTTTTTTTTTTGGAGACAGTCTTACTCTGTCACCCAAGCTGGAGTGCAATGGTGTGATCTC
GGCTCACTGCAGCCTCGGCCTCCCAGGTTTAAGTGGTTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGACTACAGGTGCCTGCCACCATGC
CTGGCTAATTTTTTTTTTTTTTTTTTTTTTTTTCAGTAGAGACAGGGTTTCACCATGTTGGCCAGACTGGTCTCAAACTCCTGACCTCAA
GTGATCTTCCTGCCTCGGCCTCCCAAAGTGTTGGGCTTACCAGTATGAGCCACCGTGCCCATCCTGTATTTCCTTTTTCAAAGGAATACA
TCTGCAGTATTTTGAGAGTAATTAGCAGAGGGTTTTTTGAGTATTTTTGGTAGGAAAAATAGATGTAGTTTTTTAATCAAATTTCTGAAA
TTGAAAATATCACTTCTTTTTAAAGAGGGATAAGTATAGTCACTCTAGTAGAAAAACATGGCTTGCCTATTTCCTCTTCTTTTCTGTTTG
CTTGGATATTGTTTAATGAATTCAAACTGTAGGTTTAGTCTTGTCTTTATAACAGTTAATGGAGAAGTGATAAAATTAAGTATTCAGCAT
AAACTAAAGATCACTCTTTGTATTTCCCCGATACATTGACAGTATGTATGTATATAGAGTTTAAATTGCTTAATATATGCACAGAAATGA
TTAGAATTTGAAGTACTATATAGAGGAGAGTTACATGGTTCTAGTGGCAGTGGATTGATTGTATTAAGGACCAAAAGAACTGCAGGATAA
TATAAAAACACCTTGAAAACTGGAGTTAGTTAGGTTTCTTTTTCTTTTTCTTTTTTTTTTTTAAAGGGCCTTACTGTACTTTTTTTTTTT
TTTTGGTCACCCAGGCTGGAGTGCAATGGCACGATCTCGGCTCACTGTAATCTCTGTCTCCTGGGTTCAAGAGATTCTCCTGTCTCAGCC
TCCCCAGTAAGTGAGATTATAGACATGCACCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAG
GCTGCTCTCGAATTCCTGACCTCAGGTGATCTGCCCACCTTGGCTTCTCAAAGTGCCAGATTACAGGCATAAGCCACTGTGCCTGGCCAG
GTTTCTGATTATAGTTTTCTTAAGTTGTAATCATCATAATTAACGTGCGCTAGAGTGTTTTAACTGTGCTGGCACTAATGCTTCTTGGCA
TATAATTAACTCTTGTTTTGCAAAAAGACCATGAAGAATGAAAGGAGGGCTTTACCTTACCTTAGTCATTTTGGGTGAATACCGTAAACT
GGGTGGCGTAACAAAACACATTTATTTCTCACAGTTGGAGGCTGAGAAACCCCAAGATCAAAGTGCCATCCAGCGCAATTCCTGATGAGG
GCCCTCTTCTGGCTTCTTGCTGTATTCTCACTTGGCAGAGAGAGAGAGACATCGTTACTTTCCTGTCTCTTCTTATAAGGGCACTAATCT
CATTCATGAGGGCTCCACCCTCATGACATGATTACCACCCAGAGGCCCCACCTCCAAATGCCATCACTTTGTATGTTAGGGCTTCAACAT
ATGAATTTGCAGACGAGGAGGAGAACATAAGCATTCAGTTCATAACATACCTATAATCTAGGTCATATCATAAACCCAGAGATGATAAGG
ATTGCCTGGTAGGCCTAACCATATATACATATACATGCATGCACACACACATATATGCATAATCTGCCTTGTTTTACATTCTTTGAGTCG
GACTTCTGTGGTCCATATGTAGAGAACATAGAGCAATAAATAACCTAGTTCAATCTTTGAGTCTTACTGAACTAGTCCTTAAACAGATGG
TATCAAGATCATTTTAGATATTAGTGACTCTCTTGTATATTAGTTATTTTTTACACTTTTAAGAACAGCATCTTTGAATCTTTTCAAGTA
CAGTATGCCTTAAATGTATAGGACCACTGAGTTCAGGAAGAAAAGCATAGGTATTCTGTAGGTGAATTACACTAACAAAATCACAACTGC
AGAATGTGATCTGATACTTTTGTTGGACAGTAAAGCTAATACATTTTATATACACAGTCATACCTTTTTTTTTTGTAATGTGTTTCGTTA
ACGTAAGCACACAGTCATCACAGACTGAGACAGGACTTTGTTAGACCAGATCTTGTGAGCTAAATATTTAAGAGCTTAACATATATAAAT
GATTTTAATTGGTATTGGGCGAAGGAAACCTAAAAATGCTTAAATTGACAGATCTTACAATTTGCTTACTGAAAATTCAGAAAGCTTTTA
TGAAAACTTTGTATTTTAAAATATTTTTTGCTCATTCTGAATTAGAAGTTAGATCCCTTTTAAAGAGGGTCTCACTCTATACAAATATAG
CCTATGAAGAATCAATAGTGAAATAATAGTGTTTATATTGAACCCCAGGATGGGACATTATTTTTTGACCATTTACATGAGGTCTTTCTC
TAATTACCAAAGTTAACCTTAAGAGTAGTTAAAAACTCAGTGAATTTTAGTCAACATTCTCTGTGGAGACCTGGACTAGTGTTTCCCAAA
CTTTCATGTGCATGTATCAAATCAGCTGAGGATATTATTAAATGGAGATTCAGATTCAATAGTTCTGGGGTGGCCTCTGGGATTATCAGT
TTCTAACAAGCTCTTAGGTGTTATCAATTCTCCTGGTCCCCAGACCATAGTTAGAGTAAAAGAGTATAGACTGCATTTAGCTTCCAGATT
TTCTCTTTCAAGGAAAGGAGACAGAACTGTCATTGTAATTCTTCCTGTGGTCCAGGCACTCTAACGTTCATCGTCTCTTCTAATGCTCTT
ACAAATCCTGTGAGGTTGGTGATAATAGAAGTTACCTCCTGAAGACGACATTCACAAGCAGGACCGACCGTGTAGACCAGTTTTCTCAAA
CTGAATAATGTACTTCACTTTTTAATAAGGAAAAAAATCTCTTAGCTCCTCAGTTTTTGCTTAATTTATATTTATTATAATGTTATCTAA
ATATATATAAACATAAAACTAGGTATAAATGCTTTATGTTTATATGTCTTGCACAAGTATAAAACCAAAACAAGTTTATGGGTTAACACA
AGCAAAACTATAAAACTAATAAAATTTAAAATAGTATTAAATAGTGATGTTTTGACAAAATGAAATTGTCACTTGTAATGTGATTATGGT
ACTGAGTGCTACAGTACAGGCTCTTTTCAGTTCAACAGGCATGTACTGCCATGTACTATGTGATGACCCAATTCACCCTGTTTTCTCCTA
TTCAGACTATTACTTTAATTTGTTCAGCACATAGTGATGTTATTTGGTCCTCATCTAGCCTGAATCCATCATTCCCCTATTAAAACAGCC
TCTGTTCTCCATAAGCCTTCCACCACTAATGTAGAACTGGGCCTTAACAGGGAAGTCAATACAAATACAAACCTAAGCACTGAGATGGTT
CTGCCAATATTTGGTTTTAATACAATTATCCAAATAATTCAGAGCATGAATATTATTTTAAAATGTTTCATCAACATGAATAATGCATAA
TTCTCATAGTAAGTTCATGGGCACTTTCCTACACCCAACACATATATACTCCACAAGGATTTTGCATGGACCCCAGTTTAAGAAGCAACA
ATTTAGTGGTCAGTAGCATTGGCGCTTTGGCTTCTGACACACTCAGACCTTGGGCCTGTTTCTCAACTTTTTCTGAACCTCAGTGTTTTT
GTGTATTCAACAGGGATAATATTAATTGAATAATTAGGAGGAACAAATGCAATAATGTACATAAAGCATGCATAGTAGTGTTTATAAATA
GCAGCCACCACTGCTTTGATTAGAAATAATAACAGCTAACATTTGAGGATTTACTGTGTGCCTTGAACGCTGCTAAGCTCTTTATATATA
TTACATATTGAGTGGTAGAATCAGGATTCAAATCCAGATCTGACTCCAAAGCGCATGCTTTTATAAAACATAATTTAAATATAGAATATC
AATGTAAATTGCTTATTTAGAAAGTTTATTTTCTTATATTTTCTCAAAAATATTTATTGTCAAATCAGTGATTCTGTAGAGGGGTAAATA
GCTAAATTTCCTTTTAAAAATTGTATGATGTGCTGATTTCAAATTGATGTGAAATACAGATTTCATTTAAAGGCAGTCATGCCAGATTGT

>In-frame_ENST00000340541_ENST00000369443_TCGA-CD-8525-01A_VAPA_chr18_9914332_+_GDAP2_chr1_118413238_length(amino acids)=105AA_start in transcript=4_stop in transcript=321
MWDPELLTQRVAHRTGDTAAGVRAREPRAWPRPRARPSRRRRRPPPPVSKPPPRARPRSALSLRWRPPQGPWRSTSRSWSSIRPQTSNSK

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Fusion Gene PPI Analysis for VAPA-GDAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VAPA-GDAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VAPA-GDAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVAPAC0005586Bipolar Disorder1PSYGENET