Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:VILL-ITGA9 (FusionGDB2 ID:97427)

Fusion Gene Summary for VILL-ITGA9

Fusion gene summary

Fusion gene information	Fusion gene name: VILL-ITGA9
	Fusion gene ID: 97427
		Hgene	Tgene
	Gene symbol	VILL	ITGA9
	Gene ID	50853	3680
	Gene name	villin like	integrin subunit alpha 9
	Synonyms	-	ALPHA-RLC\|ITGA4L\|RLC
	Cytomap	3p22.2	3p22.2
	Type of gene	protein-coding	protein-coding
	Description	villin-like protein	integrin alpha-9integrin alpha-RLC
	Modification date	20200313	20200313
	UniProtAcc	.	Q13797
	Ensembl transtripts involved in fusion gene	ENST00000283713, ENST00000383759, ENST00000465644,	ENST00000264741, ENST00000422441,
Fusion gene scores	* DoF score	4 X 4 X 4=64	9 X 9 X 4=324
	# samples	4	9
	** MAII score	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/324*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: VILL [Title/Abstract] AND ITGA9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	VILL(38035463)-ITGA9(37818883), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across VILL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ITGA9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-PG-A914-01A	VILL	chr3	38035463	+	ITGA9	chr3	37818883	+

Top

Fusion Gene ORF analysis for VILL-ITGA9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000283713	ENST00000264741	VILL	chr3	38035463	+	ITGA9	chr3	37818883	+
5CDS-intron	ENST00000283713	ENST00000422441	VILL	chr3	38035463	+	ITGA9	chr3	37818883	+
In-frame	ENST00000383759	ENST00000264741	VILL	chr3	38035463	+	ITGA9	chr3	37818883	+
5CDS-intron	ENST00000383759	ENST00000422441	VILL	chr3	38035463	+	ITGA9	chr3	37818883	+
intron-3CDS	ENST00000465644	ENST00000264741	VILL	chr3	38035463	+	ITGA9	chr3	37818883	+
intron-intron	ENST00000465644	ENST00000422441	VILL	chr3	38035463	+	ITGA9	chr3	37818883	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000283713

VILL

chr3

38035463

ENST00000264741

ITGA9

chr3

37818883

5493

401

224

967

247

ENST00000383759

VILL

chr3

38035463

ENST00000264741

ITGA9

chr3

37818883

5313

221

787

247

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000283713	ENST00000264741	VILL	chr3	38035463	+	ITGA9	chr3	37818883	+	0.001456336	0.99854374
ENST00000383759	ENST00000264741	VILL	chr3	38035463	+	ITGA9	chr3	37818883	+	0.001319737	0.9986803

Top

Fusion Genomic Features for VILL-ITGA9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
VILL	chr3	38035463	+	ITGA9	chr3	37818882	+	0.059032697	0.9409673
VILL	chr3	38035463	+	ITGA9	chr3	37818882	+	0.059032697	0.9409673

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for VILL-ITGA9

Go to
FGviewer for the breakpoints of chr3:38035463-chr3:37818883
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ITGA9 Q13797
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

1005_1009

847.0

1036.0

Motif

Note=GFFKR motif

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

1003_1035

847.0

1036.0

Topological domain

Cytoplasmic

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

982_1002

847.0

1036.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000283713

790_856

45.0

857.0

Domain

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000383759

790_856

45.0

857.0

Domain

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000283713

146_186

45.0

857.0

Repeat

Note=Gelsolin-like 2

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000283713

22_74

45.0

857.0

Repeat

Note=Gelsolin-like 1

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000283713

263_307

45.0

857.0

Repeat

Note=Gelsolin-like 3

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000283713

401_450

45.0

857.0

Repeat

Note=Gelsolin-like 4

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000283713

521_561

45.0

857.0

Repeat

Note=Gelsolin-like 5

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000283713

624_665

45.0

857.0

Repeat

Note=Gelsolin-like 6

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000383759

146_186

45.0

857.0

Repeat

Note=Gelsolin-like 2

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000383759

22_74

45.0

857.0

Repeat

Note=Gelsolin-like 1

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000383759

263_307

45.0

857.0

Repeat

Note=Gelsolin-like 3

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000383759

401_450

45.0

857.0

Repeat

Note=Gelsolin-like 4

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000383759

521_561

45.0

857.0

Repeat

Note=Gelsolin-like 5

Hgene

VILL

chr3:38035463

chr3:37818883

ENST00000383759

624_665

45.0

857.0

Repeat

Note=Gelsolin-like 6

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

312_320

847.0

1036.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

373_381

847.0

1036.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

435_443

847.0

1036.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

111_174

847.0

1036.0

Repeat

FG-GAP 2

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

182_232

847.0

1036.0

Repeat

FG-GAP 3

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

233_289

847.0

1036.0

Repeat

FG-GAP 4

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

290_349

847.0

1036.0

Repeat

FG-GAP 5

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

351_408

847.0

1036.0

Repeat

FG-GAP 6

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

35_96

847.0

1036.0

Repeat

FG-GAP 1

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

411_474

847.0

1036.0

Repeat

FG-GAP 7

Tgene

ITGA9

chr3:38035463

chr3:37818883

ENST00000264741

30_981

847.0

1036.0

Topological domain

Extracellular

Top

Fusion Gene Sequence for VILL-ITGA9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000283713_ENST00000264741_TCGA-PG-A914-01A_VILL_chr3_38035463_+_ITGA9_chr3_37818883_length(transcript)=5493nt_BP=401nt
GAGGGCGGGAAGGGCCCTCTGTGGGGCTGCCATTTTGGCTGGGACCTAAATGCAGTAAAGGAGCAGCTACGGGAATATAGAGAGTGGGGC
TTCCAGGCAGAGAAGCCTGCAGTGCAAAGGTCTGCAGACAACGACCTGGGCGTCTTCAAGGGACACAAGGAATCATATTGCCAGAACACA
TTGTACAGGTAGCCAGGTGTCGGTCTCCAGCCTGAGAACTCTGGCTGTTGTTCCTTGTGTCGTCCCATATTCCTGCCTGGCCTGCGATGG
ACATCAGCAAGGGCCTCCCAGGCATGCAGGGAGGCCTCCACATATGGATCTCTGAGAACCGGAAGATGGTGCCGGTACCCGAGGGGGCTT
ACGGGAACTTTTTTGAGGAACACTGCTATGTCATCCTCCACGTGGGCCAAGAGAAGGGAAACTGCTCTTTCCAGAAAAACCCAACTCCCT
GCATCATCCCTCAAGAACAAGAAAATATCTTCCACACAATATTTGCTTTTTTCACAAAGTCTGGAAGAAAAGTCTTGGACTGTGAAAAAC
CAGGAATTTCTTGCCTAACAGCACACTGTAACTTTAGTGCTCTTGCTAAAGAAGAAAGTCGTACTATAGACATTTACATGCTGCTGAACA
CAGAAATACTGAAAAAGGACAGTTCGTCTGTCATCCAGTTCATGTCCCGCGCCAAGGTGAAGGTGGATCCTGCCCTAAGGGTGGTGGAAA
TAGCTCATGGGAACCCAGAAGAGGTGACGGTGGTCTTCGAGGCCCTGCACAATCTGGAGCCCCGTGGCTACGTCGTGGGGTGGATCATCG
CCATCAGTTTGTTGGTGGGAATCCTCATCTTCCTGCTGCTGGCCGTGCTGCTCTGGAAGATGGGCTTCTTTCGCCGAAGGTACAAAGAAA
TTATCGAAGCTGAGAAGAACCGGAAAGAGAATGAAGACAGTTGGGACTGGGTCCAGAAAAACCAGTGAGCTGCCACACCAGTCACATGAC
CTGATCACTAGCCTGTCATCCTTGGTCTTTGTATCTTCCATATTTGGAAGAAAAAAATCTTCTCCAGATTTTTCGGAGGCCCCACTGATG
CTGTTCTCTTCTTCATTCTATCAAGCCCAGGTGCCAGCCTGAGGCAGCCACTTCGGCCAGGTCACACGACCGGGGCCAGCACCACTTCCT
TTAAAGATGAACTCTGAACTTTGGAGAGTGAGCTACAGAGCCGAGCAATATTTATGGATGCAACACGCATGGTCAACCCTCAGGGGAAAA
CTGTTACCTAAAGTATTTTTATAAATATAAGCCTTTTATACTGATTATGTCTTTTATATTTGTATCGATGTTTTATTATTTCTATTAAAT
AGTTATATAATTCACTCAAGCACTGATATCTGGCCTAAAATCTTGGAAGTACATGTCCATGAATACAAATTTTAAAGGATGAAAATCTTA
CCGTACTTTGGAACTTGCTGTTTAAAAAGACAGATGAAATAAGTTGAAGAAACCTCATGTAATGAATCCACCAGGCTGGCAGTGGTGCAT
ATAAACTGTGGGTGTGGCAAGACCCCGAAGACATTTCACATCTTTATCGCCTCGATCAAGTGTGGAGTCACATGCTAATGTGTGCTAAAG
AACTGTAAGTGTTTTTTCATATGTACTTTTCATTGGAAGATTCCCAACAAGAATTTGGATGGAAAACCTGATCCCTAGCAAGAAGTCTGC
TCTGTATCACCTTTATATAGCAGACATGTCACCCTGCTTCTACACAGATGATGGATGAAAGCTTGGAGCAATGCCATGTGGTCATCTGGT
AAACCTCAGAATGGCGTCTCATCCTGGACATCCTGCATCAGAGTTCACACACCACAAGGACTAAATCCTTGTCCCCTAAGCAAAGAATTG
GGTCTGAATGCTGTGAGGGATTGCCTTTTTGTGGTAATTTTCATTGAGAGATCTTCATTTCCCCTACCACCCTGGCTGTCCCAGCTAGTG
GTGATTGCAGATTCCTTCCCAGAGAGGACATTTAACCGTTTTAAAAAAAATGTCTTAGATTGGGTTCCCAAGAAGCAGTCCCTGAAACAA
GGATTTGTGTGCAAGTAACTTATTAAGGAAGTATTCCCAGGGGATACCAGTAAGAGAGTGGGGGAAGCAGGACAAGGAAGGAGACAAAGC
CAGGCAAATGTTTGTCATTTCAGGGAGAGCTCCATGAAGTTTAGCCTCAGCCTGATCAGGGGAACTCCGGAGGAAAAGTTAGGCCTCAGA
GGTGTCCCAACCTGAATCAAGGGGCTGGCTGCACCCAGAGGAGATGTAAACGTTTTATTCTCAATTCCTGCTGGCGTAATGGCTCCAGTA
GCTCAGGACAGTCCTCTAAAGGACAACCACAGATGCATCCTCAGCCAGGGGAGACACAGGGAAATGATGCAAAAGAAATGATGCAAAGGA
TCTGAGCAGAACACTGCCCCTCCCCACCCCCTGAATGTGTGAGTGCTGAGTTACGGCCTTCAGTATCCAAGCTCTCTGTTTGACAGTAGA
TATATTGTCAGATGCACTGTGCTGCTTAGTTTTGAGTGCAGTGTGATTTTCTGAAAGGGCAATGAGATGATGGATGTAGCATGCTCAGCA
CTGACCTGGCCCATAGTGATCACTCAATAACTGTTAACAGCTATGGCTGCTATTCCTACTGATGGATAACCATCTAATAAGACAGAAAAC
ATGGGGCTAAGAGCAGGGTCTAACGGAGTCTTAATGGCTTATTACAGCCTGCCAAAGTGCCAGCTACATACACATGGCATCCAGTGCGGA
TGAAACAATCTATAAAACCAAGGGTCTTTCTTATAGCACCTTTTTTACTGGAAGCTAACACGTTGGGAGTCCGTGAACATTGTCAAAAAG
ACATCAAACTCAACTTCTGGGAAGACAGATTTTTAATACACATACTTGGCTAATACTCACAAACATATCTAAAGTTTTGGCAAAATTATG
AGGGTGATGGGTGGGTACTAACCTGGCATGGAGCAGGTGTGTCTTTTGGTTTCTTATGCAGTTGACTCTGCTGCAGGGAGATTACAGATG
TAACCTCATGCTTCTCTTCCTGGTGAACATGGGAATAGACCAAAAAAATCAAGGGTCAATGGCATGAACTAAGCTGATCCTGGAAATCAG
GGATGTTGCATCTAACTGTGGGATGGAGGCACAGAGGTAGCTACAGGGAGCAGGACGAGGCAAAGAAAGCAGCTGTCACTCAGAGTTCGC
TTATGAGTTTTATCAAAAGCAGCAAGAAAAGCAGTCTTGGGTGGGTTTTATCACTTATTAACAGCCATTTATGAGGCCCCTGCTGTGTGT
CAGGCACTGTGCAAGGTGCTGGAGGTTCCCCAGAGAACACTTCAGGGACATTTTGCCTCAGGGTGGCAAAATGCAGTGGCATGTGGACTT
TTTGAATGGGATGCCATTTGCAGCTTTCCTTTGATGGACTCTTGTTCATAATGCCATGTTTTCTTTAATGAATCATTTAGGATTCTTAGG
TGATATTTCTGGAACAGCACCATCAACAGCTTTGGCCACATGCACTTAGAGCAACTAACTTGCCTCCTGCCGGGGTGTAGGTGCGTTGGT
GACAGTGTAGAAGGGTGATTCGCAGGCCCATGTTCTGCCCACCAGCAAAGCCCCACTGGAGAAGGGTAGACTCCTGTGGGCAGTCTCAGA
GCTGGGACCTATTTGCTTCTGCTTGATTCTGCGTGGGTGGACCCACATGAGCAGCTGTATACCCAGGAGGTCACTAAGACTTTATAAAGG
CAGGTTTTAAGAAAACCAGCCTTGGCATCACCACCAGCAGATACTGAAAGCCTCCCCAGGAACCTGTCTGGGGAAGGATGATGCCTCTGC
TGGTCTGATCGTGCTGAGTAGCAGGTGGGCTACGGGGACTGGGGAGTTAAGCATTTTGTGCAGTGATAGAGAAGTCAAGCATATCGTTAG
CGCTCTCTCAACTTGGGCAGTTCACAAGCTCCTTCCCAGCTCAGAAGCCCTCTCTATGCTCTCAGGGGAAGCAGATGGGGTGGATCAGTA
CATCTGTGTTACCCTTCCAGAATATTATTTGAAAATTCTACAGTATGTTCTACTTTCTCCCCTTCCTGCTTCCATGGTTTCACTGTGGAA
TCCTATAAGATATTCTCCTGAGCAGTATTATTTCAGTTTCCTTCAGCTTTTAGTTGAATCTTCAATGTGGTTTTAACCAACTGTTCAGAG
AACTGAAATGGTTTTTAAATATGAAAAAGGACCTTTGTAAAAATGGAGTAAAACAGTGCCCCTTTTTTAAAAAAAGTTTTGCTTATGCTT
AATTTACATAGGACTCAGGAGAGTTTGGAACATCCTCCAAGTGGGCCATAGAGCTGTCACAAAGAAGAGGCCATGATGTTTAGAAACAAG
GGGACACTAGCAGGAGGGGCAGGGTCCACTGGCTTAGTGGCAACTGACAGGCATCCATTCCGAATAACTCAGCACTGAGGTTTCCTCAGG
CAGTTCTTTAGGAAAACTGTCAGCATCATGGGTACTCAGAGGTATGGTAGACCTTGTAGAAGATCCACTAGGAAGTCCTCCTTCACCAAA
TCATGTAGCTACTGCCCTTGAGCCAAAGGCAATGAGGTTTAAAACAAAAACCCAACAGCACTCCTGGGAACATCCTGTTTTCCATGCGGA
AGCATAGCAGATCCCCAGACGATCCGTGTGCTGTATGCTACCTGTTGAACCCTAGCATGGTGGCTTTTTAAAAGGTTATTTATGACTTTT
ATTTTTGGGTAAGGCATTATGGCCAGGTGCATGCAGTTATGTCTGGGTTACGTGTGAAACGTACATCTGGTGAACTGTATACTTGGCTCA
AACTTCTCAAAATTTAGAGGTGCTGGAAAGGATTGTCACTTGGAGCCTTTAGTAGACAAAAGGCAGAAAGTGAGCATCATTTCAGAAATG
CTTTAGTATGCACACTTTTAGCTGATATTTTGATATATAGAATAATAATATACACAGTGGAGAATATTCAAAGAGTGGCTGAAGGGAGAA
TACAGAGCCAGTAGGGCCAAAATGAAACTTCTAGGATGTCTTCTGAATTTTCAGCACATGGGGGGAATAAGTGAACAAATTTCCCAACAT
CGTGCAATGCTTTATAGCACAATGATCTAGATTTCAGACTGTGTTAAGGTTTTTTCTTTGTTGATGTTGTTGTTTTAATTCTAATGTGCA
CGGTGTGACTGGCAGAGTGAGTTTAAAAGCTTTACGAGTGATTAATTGCTTGGCAGGCACCCACGCTATCTGCATTTCCAGAACTTTACT
GATGCATCCATGTACATTTCCACTGAGGAATTTTGGTGGGTGGGGGGAGGTTGTGCTGCCTCACAATGTCACGTGTATTAAAGTCTAAGC
AGTCACTTCTGATTCACTTGCACTGTTTGGGAAATGTCAGGTTTACAAAAACATACATGTTTGGAATAAAAAATGGCTGCAAACAATTCA

>In-frame_ENST00000283713_ENST00000264741_TCGA-PG-A914-01A_VILL_chr3_38035463_+_ITGA9_chr3_37818883_length(amino acids)=247AA_start in transcript=224_stop in transcript=967
MLFLVSSHIPAWPAMDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVGQEKGNCSFQKNPTPCIIPQEQENIFHTIF
AFFTKSGRKVLDCEKPGISCLTAHCNFSALAKEESRTIDIYMLLNTEILKKDSSSVIQFMSRAKVKVDPALRVVEIAHGNPEEVTVVFEA

--------------------------------------------------------------
>In-frame_ENST00000383759_ENST00000264741_TCGA-PG-A914-01A_VILL_chr3_38035463_+_ITGA9_chr3_37818883_length(transcript)=5313nt_BP=221nt
TTGTACAGGTAGCCAGGTGTCGGTCTCCAGCCTGAGAACTCTGGCTGTTGTTCCTTGTGTCGTCCCATATTCCTGCCTGGCCTGCGATGG
ACATCAGCAAGGGCCTCCCAGGCATGCAGGGAGGCCTCCACATATGGATCTCTGAGAACCGGAAGATGGTGCCGGTACCCGAGGGGGCTT
ACGGGAACTTTTTTGAGGAACACTGCTATGTCATCCTCCACGTGGGCCAAGAGAAGGGAAACTGCTCTTTCCAGAAAAACCCAACTCCCT
GCATCATCCCTCAAGAACAAGAAAATATCTTCCACACAATATTTGCTTTTTTCACAAAGTCTGGAAGAAAAGTCTTGGACTGTGAAAAAC
CAGGAATTTCTTGCCTAACAGCACACTGTAACTTTAGTGCTCTTGCTAAAGAAGAAAGTCGTACTATAGACATTTACATGCTGCTGAACA
CAGAAATACTGAAAAAGGACAGTTCGTCTGTCATCCAGTTCATGTCCCGCGCCAAGGTGAAGGTGGATCCTGCCCTAAGGGTGGTGGAAA
TAGCTCATGGGAACCCAGAAGAGGTGACGGTGGTCTTCGAGGCCCTGCACAATCTGGAGCCCCGTGGCTACGTCGTGGGGTGGATCATCG
CCATCAGTTTGTTGGTGGGAATCCTCATCTTCCTGCTGCTGGCCGTGCTGCTCTGGAAGATGGGCTTCTTTCGCCGAAGGTACAAAGAAA
TTATCGAAGCTGAGAAGAACCGGAAAGAGAATGAAGACAGTTGGGACTGGGTCCAGAAAAACCAGTGAGCTGCCACACCAGTCACATGAC
CTGATCACTAGCCTGTCATCCTTGGTCTTTGTATCTTCCATATTTGGAAGAAAAAAATCTTCTCCAGATTTTTCGGAGGCCCCACTGATG
CTGTTCTCTTCTTCATTCTATCAAGCCCAGGTGCCAGCCTGAGGCAGCCACTTCGGCCAGGTCACACGACCGGGGCCAGCACCACTTCCT
TTAAAGATGAACTCTGAACTTTGGAGAGTGAGCTACAGAGCCGAGCAATATTTATGGATGCAACACGCATGGTCAACCCTCAGGGGAAAA
CTGTTACCTAAAGTATTTTTATAAATATAAGCCTTTTATACTGATTATGTCTTTTATATTTGTATCGATGTTTTATTATTTCTATTAAAT
AGTTATATAATTCACTCAAGCACTGATATCTGGCCTAAAATCTTGGAAGTACATGTCCATGAATACAAATTTTAAAGGATGAAAATCTTA
CCGTACTTTGGAACTTGCTGTTTAAAAAGACAGATGAAATAAGTTGAAGAAACCTCATGTAATGAATCCACCAGGCTGGCAGTGGTGCAT
ATAAACTGTGGGTGTGGCAAGACCCCGAAGACATTTCACATCTTTATCGCCTCGATCAAGTGTGGAGTCACATGCTAATGTGTGCTAAAG
AACTGTAAGTGTTTTTTCATATGTACTTTTCATTGGAAGATTCCCAACAAGAATTTGGATGGAAAACCTGATCCCTAGCAAGAAGTCTGC
TCTGTATCACCTTTATATAGCAGACATGTCACCCTGCTTCTACACAGATGATGGATGAAAGCTTGGAGCAATGCCATGTGGTCATCTGGT
AAACCTCAGAATGGCGTCTCATCCTGGACATCCTGCATCAGAGTTCACACACCACAAGGACTAAATCCTTGTCCCCTAAGCAAAGAATTG
GGTCTGAATGCTGTGAGGGATTGCCTTTTTGTGGTAATTTTCATTGAGAGATCTTCATTTCCCCTACCACCCTGGCTGTCCCAGCTAGTG
GTGATTGCAGATTCCTTCCCAGAGAGGACATTTAACCGTTTTAAAAAAAATGTCTTAGATTGGGTTCCCAAGAAGCAGTCCCTGAAACAA
GGATTTGTGTGCAAGTAACTTATTAAGGAAGTATTCCCAGGGGATACCAGTAAGAGAGTGGGGGAAGCAGGACAAGGAAGGAGACAAAGC
CAGGCAAATGTTTGTCATTTCAGGGAGAGCTCCATGAAGTTTAGCCTCAGCCTGATCAGGGGAACTCCGGAGGAAAAGTTAGGCCTCAGA
GGTGTCCCAACCTGAATCAAGGGGCTGGCTGCACCCAGAGGAGATGTAAACGTTTTATTCTCAATTCCTGCTGGCGTAATGGCTCCAGTA
GCTCAGGACAGTCCTCTAAAGGACAACCACAGATGCATCCTCAGCCAGGGGAGACACAGGGAAATGATGCAAAAGAAATGATGCAAAGGA
TCTGAGCAGAACACTGCCCCTCCCCACCCCCTGAATGTGTGAGTGCTGAGTTACGGCCTTCAGTATCCAAGCTCTCTGTTTGACAGTAGA
TATATTGTCAGATGCACTGTGCTGCTTAGTTTTGAGTGCAGTGTGATTTTCTGAAAGGGCAATGAGATGATGGATGTAGCATGCTCAGCA
CTGACCTGGCCCATAGTGATCACTCAATAACTGTTAACAGCTATGGCTGCTATTCCTACTGATGGATAACCATCTAATAAGACAGAAAAC
ATGGGGCTAAGAGCAGGGTCTAACGGAGTCTTAATGGCTTATTACAGCCTGCCAAAGTGCCAGCTACATACACATGGCATCCAGTGCGGA
TGAAACAATCTATAAAACCAAGGGTCTTTCTTATAGCACCTTTTTTACTGGAAGCTAACACGTTGGGAGTCCGTGAACATTGTCAAAAAG
ACATCAAACTCAACTTCTGGGAAGACAGATTTTTAATACACATACTTGGCTAATACTCACAAACATATCTAAAGTTTTGGCAAAATTATG
AGGGTGATGGGTGGGTACTAACCTGGCATGGAGCAGGTGTGTCTTTTGGTTTCTTATGCAGTTGACTCTGCTGCAGGGAGATTACAGATG
TAACCTCATGCTTCTCTTCCTGGTGAACATGGGAATAGACCAAAAAAATCAAGGGTCAATGGCATGAACTAAGCTGATCCTGGAAATCAG
GGATGTTGCATCTAACTGTGGGATGGAGGCACAGAGGTAGCTACAGGGAGCAGGACGAGGCAAAGAAAGCAGCTGTCACTCAGAGTTCGC
TTATGAGTTTTATCAAAAGCAGCAAGAAAAGCAGTCTTGGGTGGGTTTTATCACTTATTAACAGCCATTTATGAGGCCCCTGCTGTGTGT
CAGGCACTGTGCAAGGTGCTGGAGGTTCCCCAGAGAACACTTCAGGGACATTTTGCCTCAGGGTGGCAAAATGCAGTGGCATGTGGACTT
TTTGAATGGGATGCCATTTGCAGCTTTCCTTTGATGGACTCTTGTTCATAATGCCATGTTTTCTTTAATGAATCATTTAGGATTCTTAGG
TGATATTTCTGGAACAGCACCATCAACAGCTTTGGCCACATGCACTTAGAGCAACTAACTTGCCTCCTGCCGGGGTGTAGGTGCGTTGGT
GACAGTGTAGAAGGGTGATTCGCAGGCCCATGTTCTGCCCACCAGCAAAGCCCCACTGGAGAAGGGTAGACTCCTGTGGGCAGTCTCAGA
GCTGGGACCTATTTGCTTCTGCTTGATTCTGCGTGGGTGGACCCACATGAGCAGCTGTATACCCAGGAGGTCACTAAGACTTTATAAAGG
CAGGTTTTAAGAAAACCAGCCTTGGCATCACCACCAGCAGATACTGAAAGCCTCCCCAGGAACCTGTCTGGGGAAGGATGATGCCTCTGC
TGGTCTGATCGTGCTGAGTAGCAGGTGGGCTACGGGGACTGGGGAGTTAAGCATTTTGTGCAGTGATAGAGAAGTCAAGCATATCGTTAG
CGCTCTCTCAACTTGGGCAGTTCACAAGCTCCTTCCCAGCTCAGAAGCCCTCTCTATGCTCTCAGGGGAAGCAGATGGGGTGGATCAGTA
CATCTGTGTTACCCTTCCAGAATATTATTTGAAAATTCTACAGTATGTTCTACTTTCTCCCCTTCCTGCTTCCATGGTTTCACTGTGGAA
TCCTATAAGATATTCTCCTGAGCAGTATTATTTCAGTTTCCTTCAGCTTTTAGTTGAATCTTCAATGTGGTTTTAACCAACTGTTCAGAG
AACTGAAATGGTTTTTAAATATGAAAAAGGACCTTTGTAAAAATGGAGTAAAACAGTGCCCCTTTTTTAAAAAAAGTTTTGCTTATGCTT
AATTTACATAGGACTCAGGAGAGTTTGGAACATCCTCCAAGTGGGCCATAGAGCTGTCACAAAGAAGAGGCCATGATGTTTAGAAACAAG
GGGACACTAGCAGGAGGGGCAGGGTCCACTGGCTTAGTGGCAACTGACAGGCATCCATTCCGAATAACTCAGCACTGAGGTTTCCTCAGG
CAGTTCTTTAGGAAAACTGTCAGCATCATGGGTACTCAGAGGTATGGTAGACCTTGTAGAAGATCCACTAGGAAGTCCTCCTTCACCAAA
TCATGTAGCTACTGCCCTTGAGCCAAAGGCAATGAGGTTTAAAACAAAAACCCAACAGCACTCCTGGGAACATCCTGTTTTCCATGCGGA
AGCATAGCAGATCCCCAGACGATCCGTGTGCTGTATGCTACCTGTTGAACCCTAGCATGGTGGCTTTTTAAAAGGTTATTTATGACTTTT
ATTTTTGGGTAAGGCATTATGGCCAGGTGCATGCAGTTATGTCTGGGTTACGTGTGAAACGTACATCTGGTGAACTGTATACTTGGCTCA
AACTTCTCAAAATTTAGAGGTGCTGGAAAGGATTGTCACTTGGAGCCTTTAGTAGACAAAAGGCAGAAAGTGAGCATCATTTCAGAAATG
CTTTAGTATGCACACTTTTAGCTGATATTTTGATATATAGAATAATAATATACACAGTGGAGAATATTCAAAGAGTGGCTGAAGGGAGAA
TACAGAGCCAGTAGGGCCAAAATGAAACTTCTAGGATGTCTTCTGAATTTTCAGCACATGGGGGGAATAAGTGAACAAATTTCCCAACAT
CGTGCAATGCTTTATAGCACAATGATCTAGATTTCAGACTGTGTTAAGGTTTTTTCTTTGTTGATGTTGTTGTTTTAATTCTAATGTGCA
CGGTGTGACTGGCAGAGTGAGTTTAAAAGCTTTACGAGTGATTAATTGCTTGGCAGGCACCCACGCTATCTGCATTTCCAGAACTTTACT
GATGCATCCATGTACATTTCCACTGAGGAATTTTGGTGGGTGGGGGGAGGTTGTGCTGCCTCACAATGTCACGTGTATTAAAGTCTAAGC
AGTCACTTCTGATTCACTTGCACTGTTTGGGAAATGTCAGGTTTACAAAAACATACATGTTTGGAATAAAAAATGGCTGCAAACAATTCA

>In-frame_ENST00000383759_ENST00000264741_TCGA-PG-A914-01A_VILL_chr3_38035463_+_ITGA9_chr3_37818883_length(amino acids)=247AA_start in transcript=44_stop in transcript=787
MLFLVSSHIPAWPAMDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVGQEKGNCSFQKNPTPCIIPQEQENIFHTIF
AFFTKSGRKVLDCEKPGISCLTAHCNFSALAKEESRTIDIYMLLNTEILKKDSSSVIQFMSRAKVKVDPALRVVEIAHGNPEEVTVVFEA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for VILL-ITGA9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for VILL-ITGA9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for VILL-ITGA9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	ITGA9	C0005586	Bipolar Disorder	1	PSYGENET
Tgene	ITGA9	C1839839	MAJOR AFFECTIVE DISORDER 2	1	PSYGENET