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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VMP1-PSMA6 (FusionGDB2 ID:97537)

Fusion Gene Summary for VMP1-PSMA6

check button Fusion gene summary
Fusion gene informationFusion gene name: VMP1-PSMA6
Fusion gene ID: 97537
HgeneTgene
Gene symbol

VMP1

PSMA6

Gene ID

81671

5687

Gene namevacuole membrane protein 1proteasome 20S subunit alpha 6
SynonymsEPG3|TANGO5|TMEM49IOTA|PROS27|p27K
Cytomap

17q23.1

14q13.2

Type of geneprotein-codingprotein-coding
Descriptionvacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homologproteasome subunit alpha type-627 kDa prosomal proteinPROS-27macropain iota chainmacropain subunit iotamulticatalytic endopeptidase complex iota chainprosomal P27K proteinproteasome (prosome, macropain) subunit, alpha type, 6proteasome iota chain
Modification date2020032720200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262291, ENST00000537567, 
ENST00000539763, ENST00000536180, 
ENST00000545362, ENST00000588617, 
ENST00000540871, ENST00000261479, 
ENST00000553809, ENST00000555764, 
ENST00000556506, 
Fusion gene scores* DoF score34 X 17 X 12=693612 X 9 X 7=756
# samples 3812
** MAII scorelog2(38/6936*10)=-4.19003257489089
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/756*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: VMP1 [Title/Abstract] AND PSMA6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVMP1(57851246)-PSMA6(35786455), # samples:3
Anticipated loss of major functional domain due to fusion event.VMP1-PSMA6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
VMP1-PSMA6 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
VMP1-PSMA6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across VMP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PSMA6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A09A-01AVMP1chr17

57851246

+PSMA6chr14

35786455

+
ChimerDB4BRCATCGA-A8-A09A-01AVMP1chr17

57851246

+PSMA6chr14

35786455

+
ChimerDB4BRCATCGA-A8-A09A-01AVMP1chr17

57851246

-PSMA6chr14

35786455

+


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Fusion Gene ORF analysis for VMP1-PSMA6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000262291ENST00000540871VMP1chr17

57851246

+PSMA6chr14

35786455

+
In-frameENST00000262291ENST00000261479VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000262291ENST00000553809VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000262291ENST00000555764VMP1chr17

57851246

+PSMA6chr14

35786455

+
In-frameENST00000262291ENST00000556506VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000537567ENST00000540871VMP1chr17

57851246

+PSMA6chr14

35786455

+
In-frameENST00000537567ENST00000261479VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000537567ENST00000553809VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000537567ENST00000555764VMP1chr17

57851246

+PSMA6chr14

35786455

+
In-frameENST00000537567ENST00000556506VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000539763ENST00000540871VMP1chr17

57851246

+PSMA6chr14

35786455

+
In-frameENST00000539763ENST00000261479VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000539763ENST00000553809VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000539763ENST00000555764VMP1chr17

57851246

+PSMA6chr14

35786455

+
In-frameENST00000539763ENST00000556506VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000536180ENST00000540871VMP1chr17

57851246

+PSMA6chr14

35786455

+
In-frameENST00000536180ENST00000261479VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000536180ENST00000553809VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000536180ENST00000555764VMP1chr17

57851246

+PSMA6chr14

35786455

+
In-frameENST00000536180ENST00000556506VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000545362ENST00000540871VMP1chr17

57851246

+PSMA6chr14

35786455

+
In-frameENST00000545362ENST00000261479VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000545362ENST00000553809VMP1chr17

57851246

+PSMA6chr14

35786455

+
Frame-shiftENST00000545362ENST00000555764VMP1chr17

57851246

+PSMA6chr14

35786455

+
In-frameENST00000545362ENST00000556506VMP1chr17

57851246

+PSMA6chr14

35786455

+
intron-3CDSENST00000588617ENST00000540871VMP1chr17

57851246

+PSMA6chr14

35786455

+
intron-3CDSENST00000588617ENST00000261479VMP1chr17

57851246

+PSMA6chr14

35786455

+
intron-3CDSENST00000588617ENST00000553809VMP1chr17

57851246

+PSMA6chr14

35786455

+
intron-3CDSENST00000588617ENST00000555764VMP1chr17

57851246

+PSMA6chr14

35786455

+
intron-3CDSENST00000588617ENST00000556506VMP1chr17

57851246

+PSMA6chr14

35786455

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262291VMP1chr1757851246+ENST00000261479PSMA6chr1435786455+125010242531047264
ENST00000262291VMP1chr1757851246+ENST00000556506PSMA6chr1435786455+119510242531047264
ENST00000537567VMP1chr1757851246+ENST00000261479PSMA6chr1435786455+865639327662111
ENST00000537567VMP1chr1757851246+ENST00000556506PSMA6chr1435786455+810639327662111
ENST00000539763VMP1chr1757851246+ENST00000261479PSMA6chr1435786455+929703238726162
ENST00000539763VMP1chr1757851246+ENST00000556506PSMA6chr1435786455+874703238726162
ENST00000536180VMP1chr1757851246+ENST00000261479PSMA6chr1435786455+959733310756148
ENST00000536180VMP1chr1757851246+ENST00000556506PSMA6chr1435786455+904733310756148
ENST00000545362VMP1chr1757851246+ENST00000261479PSMA6chr1435786455+82559941622193
ENST00000545362VMP1chr1757851246+ENST00000556506PSMA6chr1435786455+77059941622193

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262291ENST00000261479VMP1chr1757851246+PSMA6chr1435786455+0.0053396940.9946603
ENST00000262291ENST00000556506VMP1chr1757851246+PSMA6chr1435786455+0.004424770.9955752
ENST00000537567ENST00000261479VMP1chr1757851246+PSMA6chr1435786455+0.0132277760.98677224
ENST00000537567ENST00000556506VMP1chr1757851246+PSMA6chr1435786455+0.0112727150.9887272
ENST00000539763ENST00000261479VMP1chr1757851246+PSMA6chr1435786455+0.0522509180.94774914
ENST00000539763ENST00000556506VMP1chr1757851246+PSMA6chr1435786455+0.0370574440.9629426
ENST00000536180ENST00000261479VMP1chr1757851246+PSMA6chr1435786455+0.007414280.9925857
ENST00000536180ENST00000556506VMP1chr1757851246+PSMA6chr1435786455+0.0047007970.9952992
ENST00000545362ENST00000261479VMP1chr1757851246+PSMA6chr1435786455+0.002765980.99723405
ENST00000545362ENST00000556506VMP1chr1757851246+PSMA6chr1435786455+0.001828310.9981717

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Fusion Genomic Features for VMP1-PSMA6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
VMP1chr1757851246+PSMA6chr1435786454+1.75E-101
VMP1chr1757851246+PSMA6chr1435786454+1.75E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VMP1-PSMA6


check button Go to

FGviewer for the breakpoints of chr17:57851246-chr14:35786455

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+7122_43238.0407.0Topological domainCytoplasmic
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+71265_77238.0407.0Topological domainExtracellular
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+71299_109238.0407.0Topological domainCytoplasmic
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+712110_130238.0407.0TransmembraneHelical
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+71244_64238.0407.0TransmembraneHelical
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+71278_98238.0407.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+712173_316238.0407.0RegionVTT domain
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+712131_250238.0407.0Topological domainExtracellular
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+712272_273238.0407.0Topological domainCytoplasmic
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+712295_305238.0407.0Topological domainExtracellular
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+712327_363238.0407.0Topological domainCytoplasmic
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+712385_406238.0407.0Topological domainExtracellular
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+712251_271238.0407.0TransmembraneHelical
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+712274_294238.0407.0TransmembraneHelical
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+712306_326238.0407.0TransmembraneHelical
HgeneVMP1chr17:57851246chr14:35786455ENST00000262291+712364_384238.0407.0TransmembraneHelical


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Fusion Gene Sequence for VMP1-PSMA6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262291_ENST00000261479_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(transcript)=1250nt_BP=1024nt
GACAAGTTCCGGATCAAGAATCACAAAGCGAGCAGTCATTCTTCCTCTTGCCACACCCACAGGGCCCGCACTAAGAGCCTAACTGAAATC
CCGCGAGGATCAACCGAGCTCGCCGAAAGGAGGGAGGAACGTATCCCTTCTGGAGGCTGTCTCAGGGGGCAGAGGGACCGGACCGGAAGT
GACGTGAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGC
CGGGGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAA
GGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTG
GAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTATGGCATCGTCAAAG
CATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTATGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGA
GAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTA
TCTGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTAT
TTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGG
TACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATT
TGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACT
AAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGA

>In-frame_ENST00000262291_ENST00000261479_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(amino acids)=264AA_start in transcript=253_stop in transcript=1047
MRSGAAGVGAAPQELLIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSK
LWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPP

--------------------------------------------------------------
>In-frame_ENST00000262291_ENST00000556506_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(transcript)=1195nt_BP=1024nt
GACAAGTTCCGGATCAAGAATCACAAAGCGAGCAGTCATTCTTCCTCTTGCCACACCCACAGGGCCCGCACTAAGAGCCTAACTGAAATC
CCGCGAGGATCAACCGAGCTCGCCGAAAGGAGGGAGGAACGTATCCCTTCTGGAGGCTGTCTCAGGGGGCAGAGGGACCGGACCGGAAGT
GACGTGAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGC
CGGGGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAA
GGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTG
GAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTATGGCATCGTCAAAG
CATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTATGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGA
GAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTA
TCTGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTAT
TTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGG
TACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATT
TGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACT
AAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGA

>In-frame_ENST00000262291_ENST00000556506_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(amino acids)=264AA_start in transcript=253_stop in transcript=1047
MRSGAAGVGAAPQELLIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSK
LWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPP

--------------------------------------------------------------
>In-frame_ENST00000537567_ENST00000261479_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(transcript)=865nt_BP=639nt
GTGAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGG
GGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGA
ACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAG
ACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAGGTCCACATATAGCCTCAGTT
ACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAA
GGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCA
TATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAG
TCTGCACAAGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGAT
CCGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCT

>In-frame_ENST00000537567_ENST00000261479_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(amino acids)=111AA_start in transcript=327_stop in transcript=662
MDLKGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEY

--------------------------------------------------------------
>In-frame_ENST00000537567_ENST00000556506_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(transcript)=810nt_BP=639nt
GTGAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGG
GGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGA
ACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAG
ACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAGGTCCACATATAGCCTCAGTT
ACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAA
GGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCA
TATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAG
TCTGCACAAGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGAT
CCGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCT

>In-frame_ENST00000537567_ENST00000556506_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(amino acids)=111AA_start in transcript=327_stop in transcript=662
MDLKGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEY

--------------------------------------------------------------
>In-frame_ENST00000539763_ENST00000261479_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(transcript)=929nt_BP=703nt
GAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGGGG
TCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAAC
ATCATAATGGAAATTTCACAGATTATGGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTA
TGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTC
TGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTC
AGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCAT
CTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCT
CTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGATTCTTACAGAAGCAG
AGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTT
GGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCACCGAAGTGGTTAGGACTCTATA

>In-frame_ENST00000539763_ENST00000261479_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(amino acids)=162AA_start in transcript=238_stop in transcript=726
MLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEG

--------------------------------------------------------------
>In-frame_ENST00000539763_ENST00000556506_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(transcript)=874nt_BP=703nt
GAGCGGGTTCCGGTTGTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGGGG
TCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAAC
ATCATAATGGAAATTTCACAGATTATGGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTA
TGTTGAAGGAGTGCATCAACAGTATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTC
TGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTCCACATATAGCCTCAGTTACATTAGCTGCTTATGAATGCAATTC
AGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCACTGAAGGAACCATTTCTTTGTGGAGTATCAT
CTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCT
CTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGATTCTTACAGAAGCAG
AGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTT

>In-frame_ENST00000539763_ENST00000556506_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(amino acids)=162AA_start in transcript=238_stop in transcript=726
MLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEG

--------------------------------------------------------------
>In-frame_ENST00000536180_ENST00000261479_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(transcript)=959nt_BP=733nt
GTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGGGGTCGGAGCGGCTCCTC
AAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAACATCATAATGGAAATT
TCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAGACAGCCGCTCATTACCT
TGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAATATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGC
CTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTCCACATATAGCCTC
AGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCAC
TGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCC
TCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGC
AGAGTCTGCACAAGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACC
AGATCCGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCC

>In-frame_ENST00000536180_ENST00000261479_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(amino acids)=148AA_start in transcript=310_stop in transcript=756
MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKV

--------------------------------------------------------------
>In-frame_ENST00000536180_ENST00000556506_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(transcript)=904nt_BP=733nt
GTCTGGAGCCCAGCGGCGGGTGTGAGAGTCCGTAAGGAGCAGCTTCCAGGATCCTGAGATCCGGAGCAGCCGGGGTCGGAGCGGCTCCTC
AAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTGTAGCAATGAACAAGGAACATCATAATGGAAATT
TCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGAATATTGTCCTGTGGAGACAGCCGCTCATTACCT
TGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAATATGTGCAACGTATAGAGAAACAGTTTCTTTTGTATGC
CTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACACCTTTCTGCTTTATCTGGGTCCACATATAGCCTC
AGTTACATTAGCTGCTTATGAATGCAATTCAGTTAATTTTCCCGAACCACCCTATCCTGATCAGATTATTTGTCCAGATGAAGAGGGCAC
TGAAGGAACCATTTCTTTGTGGAGTATCATCTCAAAAGTTAGGATTGAAGCCTGCATGTGGGGTATCGGTACAGCAATCGGAGAGCTGCC
TCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAACCAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGC
AGAGTCTGCACAAGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACC
AGATCCGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCC

>In-frame_ENST00000536180_ENST00000556506_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(amino acids)=148AA_start in transcript=310_stop in transcript=756
MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKV

--------------------------------------------------------------
>In-frame_ENST00000545362_ENST00000261479_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(transcript)=825nt_BP=599nt
GATCCGGAGCAGCCGGGGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTG
TAGCAATGAACAAGGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGA
ATATTGTCCTGTGGAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTAT
GGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTATGTTGAAGGAGTGCATCAACAGTATG
TGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACA
CCTTTCTGCTTTATCTGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAAC
CAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGATTCTTACAGAAGCAGAGATTGATGCTCAC
CTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACC
AACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCACCGAAGTGGTTAGGACTCTATATAAATAAAAACAAG

>In-frame_ENST00000545362_ENST00000261479_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(amino acids)=193AA_start in transcript=41_stop in transcript=622
MIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLL
AVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLE

--------------------------------------------------------------
>In-frame_ENST00000545362_ENST00000556506_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(transcript)=770nt_BP=599nt
GATCCGGAGCAGCCGGGGTCGGAGCGGCTCCTCAAGAGTTACTGATCTATGAAATGGCAGAGAATGGAAAAAATTGTGACCAGAGACGTG
TAGCAATGAACAAGGAACATCATAATGGAAATTTCACAGACCCCTCTTCAGTGAATGAAAAGAAGAGGAGGGAGCGGGAAGAAAGGCAGA
ATATTGTCCTGTGGAGACAGCCGCTCATTACCTTGCAGTATTTTTCTCTGGAAATCCTTGTAATCTTGAAGGAATGGACCTCAAAATTAT
GGCATCGTCAAAGCATTGTGGTGTCTTTTTTACTGCTGCTTGCTGTGCTTATAGCTACGTATTATGTTGAAGGAGTGCATCAACAGTATG
TGCAACGTATAGAGAAACAGTTTCTTTTGTATGCCTACTGGATAGGCTTAGGAATTTTGTCTTCTGTTGGGCTTGGAACAGGGCTGCACA
CCTTTCTGCTTTATCTGGGTATCGGTACAGCAATCGGAGAGCTGCCTCCATATTTCATGGCCAGAGCAGCTCGCCTCTCAGGTGCTGAAC
CAGATGATGAAGAGTATCAGGAATTTGAAGAGATGCTGGAACATGCAGAGTCTGCACAAGATTCTTACAGAAGCAGAGATTGATGCTCAC
CTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTTGGTAACAACAAACC

>In-frame_ENST00000545362_ENST00000556506_TCGA-A8-A09A-01A_VMP1_chr17_57851246_+_PSMA6_chr14_35786455_length(amino acids)=193AA_start in transcript=41_stop in transcript=622
MIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLL
AVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for VMP1-PSMA6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VMP1-PSMA6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VMP1-PSMA6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePSMA6C0019693HIV Infections1CTD_human
TgenePSMA6C0027051Myocardial Infarction1CTD_human
TgenePSMA6C4505456HIV Coinfection1CTD_human