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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:VPS53-UBR5 (FusionGDB2 ID:97822) |
Fusion Gene Summary for VPS53-UBR5 |
Fusion gene summary |
Fusion gene information | Fusion gene name: VPS53-UBR5 | Fusion gene ID: 97822 | Hgene | Tgene | Gene symbol | VPS53 | UBR5 | Gene ID | 55275 | 51366 |
Gene name | VPS53 subunit of GARP complex | ubiquitin protein ligase E3 component n-recognin 5 | |
Synonyms | HCCS1|PCH2E|hVps53L|pp13624 | DD5|EDD|EDD1|HYD | |
Cytomap | 17p13.3 | 8q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | vacuolar protein sorting-associated protein 53 homologVPS53, GARP complex subunit | E3 ubiquitin-protein ligase UBR5E3 identified by differential displayE3 ubiquitin-protein ligase, HECT domain-containing 1HECT-type E3 ubiquitin transferase UBR5hyperplastic discs protein homologprogestin-induced protein | |
Modification date | 20200313 | 20200315 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000437048, ENST00000574029, ENST00000576149, ENST00000446250, ENST00000291074, ENST00000571805, ENST00000401468, | ENST00000520539, ENST00000220959, ENST00000518205, ENST00000521922, ENST00000519528, | |
Fusion gene scores | * DoF score | 18 X 15 X 14=3780 | 14 X 17 X 10=2380 |
# samples | 24 | 19 | |
** MAII score | log2(24/3780*10)=-3.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/2380*10)=-3.64689024986436 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: VPS53 [Title/Abstract] AND UBR5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | VPS53(526773)-UBR5(103277506), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | VPS53-UBR5 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. VPS53-UBR5 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. VPS53-UBR5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. VPS53-UBR5 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | UBR5 | GO:0000209 | protein polyubiquitination | 21118991|28689657 |
Tgene | UBR5 | GO:0006974 | cellular response to DNA damage stimulus | 12011095 |
Tgene | UBR5 | GO:0010628 | positive regulation of gene expression | 18076571 |
Tgene | UBR5 | GO:0050847 | progesterone receptor signaling pathway | 12011095 |
Tgene | UBR5 | GO:0070936 | protein K48-linked ubiquitination | 28689657 |
Fusion gene breakpoints across VPS53 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across UBR5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | TCGA-IN-8462-11A | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
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Fusion Gene ORF analysis for VPS53-UBR5 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000437048 | ENST00000520539 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
In-frame | ENST00000437048 | ENST00000220959 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
In-frame | ENST00000437048 | ENST00000518205 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
In-frame | ENST00000437048 | ENST00000521922 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
5CDS-intron | ENST00000437048 | ENST00000519528 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
intron-3CDS | ENST00000574029 | ENST00000520539 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
intron-3CDS | ENST00000574029 | ENST00000220959 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
intron-3CDS | ENST00000574029 | ENST00000518205 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
intron-3CDS | ENST00000574029 | ENST00000521922 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
intron-intron | ENST00000574029 | ENST00000519528 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
5UTR-3CDS | ENST00000576149 | ENST00000520539 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
5UTR-3CDS | ENST00000576149 | ENST00000220959 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
5UTR-3CDS | ENST00000576149 | ENST00000518205 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
5UTR-3CDS | ENST00000576149 | ENST00000521922 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
5UTR-intron | ENST00000576149 | ENST00000519528 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
Frame-shift | ENST00000446250 | ENST00000520539 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
Frame-shift | ENST00000446250 | ENST00000220959 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
Frame-shift | ENST00000446250 | ENST00000518205 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
Frame-shift | ENST00000446250 | ENST00000521922 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
5CDS-intron | ENST00000446250 | ENST00000519528 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
In-frame | ENST00000291074 | ENST00000520539 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
In-frame | ENST00000291074 | ENST00000220959 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
In-frame | ENST00000291074 | ENST00000518205 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
In-frame | ENST00000291074 | ENST00000521922 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
5CDS-intron | ENST00000291074 | ENST00000519528 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
In-frame | ENST00000571805 | ENST00000520539 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
In-frame | ENST00000571805 | ENST00000220959 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
In-frame | ENST00000571805 | ENST00000518205 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
In-frame | ENST00000571805 | ENST00000521922 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
5CDS-intron | ENST00000571805 | ENST00000519528 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
intron-3CDS | ENST00000401468 | ENST00000520539 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
intron-3CDS | ENST00000401468 | ENST00000220959 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
intron-3CDS | ENST00000401468 | ENST00000518205 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
intron-3CDS | ENST00000401468 | ENST00000521922 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
intron-intron | ENST00000401468 | ENST00000519528 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000437048 | VPS53 | chr17 | 526773 | - | ENST00000520539 | UBR5 | chr8 | 103277506 | - | 3531 | 1263 | 147 | 2240 | 697 |
ENST00000437048 | VPS53 | chr17 | 526773 | - | ENST00000220959 | UBR5 | chr8 | 103277506 | - | 2804 | 1263 | 147 | 2237 | 696 |
ENST00000437048 | VPS53 | chr17 | 526773 | - | ENST00000518205 | UBR5 | chr8 | 103277506 | - | 2342 | 1263 | 147 | 2237 | 696 |
ENST00000437048 | VPS53 | chr17 | 526773 | - | ENST00000521922 | UBR5 | chr8 | 103277506 | - | 2342 | 1263 | 147 | 2237 | 696 |
ENST00000291074 | VPS53 | chr17 | 526773 | - | ENST00000520539 | UBR5 | chr8 | 103277506 | - | 3431 | 1163 | 134 | 2140 | 668 |
ENST00000291074 | VPS53 | chr17 | 526773 | - | ENST00000220959 | UBR5 | chr8 | 103277506 | - | 2704 | 1163 | 134 | 2137 | 667 |
ENST00000291074 | VPS53 | chr17 | 526773 | - | ENST00000518205 | UBR5 | chr8 | 103277506 | - | 2242 | 1163 | 134 | 2137 | 667 |
ENST00000291074 | VPS53 | chr17 | 526773 | - | ENST00000521922 | UBR5 | chr8 | 103277506 | - | 2242 | 1163 | 134 | 2137 | 667 |
ENST00000571805 | VPS53 | chr17 | 526773 | - | ENST00000520539 | UBR5 | chr8 | 103277506 | - | 3521 | 1253 | 137 | 2230 | 697 |
ENST00000571805 | VPS53 | chr17 | 526773 | - | ENST00000220959 | UBR5 | chr8 | 103277506 | - | 2794 | 1253 | 137 | 2227 | 696 |
ENST00000571805 | VPS53 | chr17 | 526773 | - | ENST00000518205 | UBR5 | chr8 | 103277506 | - | 2332 | 1253 | 137 | 2227 | 696 |
ENST00000571805 | VPS53 | chr17 | 526773 | - | ENST00000521922 | UBR5 | chr8 | 103277506 | - | 2332 | 1253 | 137 | 2227 | 696 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000437048 | ENST00000520539 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - | 0.000734665 | 0.9992654 |
ENST00000437048 | ENST00000220959 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - | 0.001998937 | 0.99800104 |
ENST00000437048 | ENST00000518205 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - | 0.003831013 | 0.99616903 |
ENST00000437048 | ENST00000521922 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - | 0.003831013 | 0.99616903 |
ENST00000291074 | ENST00000520539 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - | 0.000394775 | 0.99960524 |
ENST00000291074 | ENST00000220959 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - | 0.001279283 | 0.9987207 |
ENST00000291074 | ENST00000518205 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - | 0.002598106 | 0.99740195 |
ENST00000291074 | ENST00000521922 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - | 0.002598106 | 0.99740195 |
ENST00000571805 | ENST00000520539 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - | 0.000732153 | 0.9992679 |
ENST00000571805 | ENST00000220959 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - | 0.001975424 | 0.9980246 |
ENST00000571805 | ENST00000518205 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - | 0.003782756 | 0.9962172 |
ENST00000571805 | ENST00000521922 | VPS53 | chr17 | 526773 | - | UBR5 | chr8 | 103277506 | - | 0.003782756 | 0.9962172 |
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Fusion Genomic Features for VPS53-UBR5 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for VPS53-UBR5 |
Go to FGviewer for the breakpoints of chr17:526773-chr8:103277506 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | VPS53 | chr17:526773 | chr8:103277506 | ENST00000291074 | - | 10 | 18 | 97_138 | 343.0 | 671.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | VPS53 | chr17:526773 | chr8:103277506 | ENST00000437048 | - | 11 | 22 | 97_138 | 372.0 | 833.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | VPS53 | chr17:526773 | chr8:103277506 | ENST00000571805 | - | 11 | 19 | 97_138 | 372.0 | 700.0 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 2489_2500 | 2474.0 | 2800.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 2737_2757 | 2474.0 | 2800.0 | Compositional bias | Note=Pro-rich |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 1528_1537 | 2474.0 | 2800.0 | Compositional bias | Note=Poly-Ser | |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 1671_1681 | 2474.0 | 2800.0 | Compositional bias | Note=Poly-Ser | |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 1762_1768 | 2474.0 | 2800.0 | Compositional bias | Note=Poly-Ala | |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 1986_1997 | 2474.0 | 2800.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 2036_2059 | 2474.0 | 2800.0 | Compositional bias | Note=Pro-rich | |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 2329_2348 | 2474.0 | 2800.0 | Compositional bias | Note=Arg/Glu-rich (mixed charge) | |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 2357_2366 | 2474.0 | 2800.0 | Compositional bias | Note=Arg/Asp-rich (mixed charge) | |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 940_945 | 2474.0 | 2800.0 | Compositional bias | Note=Poly-Glu | |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 980_985 | 2474.0 | 2800.0 | Compositional bias | Note=Poly-Ser | |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 2377_2454 | 2474.0 | 2800.0 | Domain | PABC | |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 2462_2799 | 2474.0 | 2800.0 | Domain | HECT | |
Tgene | UBR5 | chr17:526773 | chr8:103277506 | ENST00000520539 | 51 | 59 | 1177_1245 | 2474.0 | 2800.0 | Zinc finger | UBR-type |
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Fusion Gene Sequence for VPS53-UBR5 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000437048_ENST00000520539_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(transcript)=3531nt_BP=1263nt GAAGTGCCGGAGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGG CGGCTGGAGGCCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAG GAGCTGGAAGCCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGAT TTCAATGCTGTTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAA ATAAGGAGACTGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAG AAAGCTATCCAACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGAT ATTAAGCAATTAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCC CTCGAAGCCATGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTAT ATGGGGATTCCGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAA GCGTTTCCTTCCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGG ATCAAACAGGAAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTG GACAAAATCGACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGC ATGGCTGAGAGGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTG AAATTGCTTCTTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACC CTGCAGGAAAACCGAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCT TTGTTTTACCAACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGC AGGATTCTTGGACTATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTC AATTGGCATGATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCT GTTTTCTCAGCAATGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAAT ATACCAGTCACTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCA ATGAGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGT GAAGTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGG TTCTGGTCAATAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAA GAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTAC GTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAA AGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATAC CCCCCTGGTGGTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGC TATATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTT TGCTGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATA GGGAATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGT ATCATGTATATGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCG GTTTGACTGCATTGAGCTCTAGGATATTAAATGATATCACTAATATTTTGCATGTAATTTGCTCATTTGAGTGAGGGCACTTTTTTTGTA CATATGATGGGGCCAATGCACAATACTTTTATCACAATCAACTTTTTCTTTGTATCCCTATTTCAATGAGCAGTCAGTCTCAAGAGGTTA CTGCACTTCAGTTCTAACTAGACATTTGTACTAAGGTATTTCAGTTATGTAAACTCAGCCTGGGCACTTTCTGATAACTGTAAAATGTTT TATAAGATCATGATTATTGAAGATACATTTTGGAAAATTTTAAATGTTCGTGAGCAGCTTAACTACTTTTGTATCTAGCCTTTTTTAAGT ATCTTGTTACATTTACTTTTTTAAATAAAGAAATTACAGAAGAAATGTCAAGTAATATTGAAGAAACAATAGTTTTTATTTATGTAGTTG TACATTTTTAAACTAAGGGCAATACACTGACATGGTTATGTGCATAAAAATTTTGACTTAAAGAACTGGAAGTTTATATACACCTGGACT ATAAGAAACAGAAGAAAATCAGTCCACATTTTACAGTTAGCAGAGAATCCTAAATGGCACTGGCCTGGCCACCTTTTCATTTTACAAATG GGGGAAGTGAAGTGTGACCCCTTACTTGGCATAGGAAGTTAACTTACACCTAATAACTGACAGGTTTTTGTTTTGATGACCTATTAATTA >In-frame_ENST00000437048_ENST00000520539_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(amino acids)=697AA_start in transcript=147_stop in transcript=2240 MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK RFSGCTLTDGTLQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNR HVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHR MLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYF -------------------------------------------------------------- >In-frame_ENST00000437048_ENST00000220959_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(transcript)=2804nt_BP=1263nt GAAGTGCCGGAGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGG CGGCTGGAGGCCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAG GAGCTGGAAGCCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGAT TTCAATGCTGTTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAA ATAAGGAGACTGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAG AAAGCTATCCAACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGAT ATTAAGCAATTAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCC CTCGAAGCCATGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTAT ATGGGGATTCCGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAA GCGTTTCCTTCCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGG ATCAAACAGGAAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTG GACAAAATCGACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGC ATGGCTGAGAGGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTG AAATTGCTTCTTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACC CTGGAAAACCGAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTG TTTTACCAACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGG ATTCTTGGACTATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAAT TGGCATGATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTT TTCTCAGCAATGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATA CCAGTCACTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATG AGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAA GTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTC TGGTCAATAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAA GGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTC CCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGT GTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCC CCTGGTGGTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTAT ATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGC TGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGG AATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATC ATGTATATGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTT >In-frame_ENST00000437048_ENST00000220959_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(amino acids)=696AA_start in transcript=147_stop in transcript=2237 MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW -------------------------------------------------------------- >In-frame_ENST00000437048_ENST00000518205_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(transcript)=2342nt_BP=1263nt GAAGTGCCGGAGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGG CGGCTGGAGGCCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAG GAGCTGGAAGCCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGAT TTCAATGCTGTTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAA ATAAGGAGACTGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAG AAAGCTATCCAACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGAT ATTAAGCAATTAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCC CTCGAAGCCATGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTAT ATGGGGATTCCGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAA GCGTTTCCTTCCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGG ATCAAACAGGAAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTG GACAAAATCGACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGC ATGGCTGAGAGGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTG AAATTGCTTCTTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACC CTGGAAAACCGAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTG TTTTACCAACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGG ATTCTTGGACTATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAAT TGGCATGATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTT TTCTCAGCAATGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATA CCAGTCACTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATG AGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAA GTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTC TGGTCAATAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAA GGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTC CCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGT GTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCC >In-frame_ENST00000437048_ENST00000518205_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(amino acids)=696AA_start in transcript=147_stop in transcript=2237 MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW -------------------------------------------------------------- >In-frame_ENST00000437048_ENST00000521922_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(transcript)=2342nt_BP=1263nt GAAGTGCCGGAGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGG CGGCTGGAGGCCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAG GAGCTGGAAGCCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGAT TTCAATGCTGTTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAA ATAAGGAGACTGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAG AAAGCTATCCAACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGAT ATTAAGCAATTAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCC CTCGAAGCCATGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTAT ATGGGGATTCCGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAA GCGTTTCCTTCCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGG ATCAAACAGGAAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTG GACAAAATCGACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGC ATGGCTGAGAGGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTG AAATTGCTTCTTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACC CTGGAAAACCGAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTG TTTTACCAACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGG ATTCTTGGACTATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAAT TGGCATGATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTT TTCTCAGCAATGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATA CCAGTCACTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATG AGGAAAGGTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAA GTCAATGTGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTC TGGTCAATAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAA GGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTC CCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGT GTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCC >In-frame_ENST00000437048_ENST00000521922_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(amino acids)=696AA_start in transcript=147_stop in transcript=2237 MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW -------------------------------------------------------------- >In-frame_ENST00000291074_ENST00000520539_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(transcript)=3431nt_BP=1163nt GGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGGCCT GAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAGCCG TGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTGTTG AGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGACTGG ATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGTGAAAGAAATCACCCGTGATATTAAGCAAT TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGCAGGAAA ACCGAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACC AACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTG GACTATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATG ATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAG CAATGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCA CTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAG GTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATG TGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAA TAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCC AGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCT ATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATT GCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTG GTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTT TGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGG GAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCA AAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATA TGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTTTGACTGC ATTGAGCTCTAGGATATTAAATGATATCACTAATATTTTGCATGTAATTTGCTCATTTGAGTGAGGGCACTTTTTTTGTACATATGATGG GGCCAATGCACAATACTTTTATCACAATCAACTTTTTCTTTGTATCCCTATTTCAATGAGCAGTCAGTCTCAAGAGGTTACTGCACTTCA GTTCTAACTAGACATTTGTACTAAGGTATTTCAGTTATGTAAACTCAGCCTGGGCACTTTCTGATAACTGTAAAATGTTTTATAAGATCA TGATTATTGAAGATACATTTTGGAAAATTTTAAATGTTCGTGAGCAGCTTAACTACTTTTGTATCTAGCCTTTTTTAAGTATCTTGTTAC ATTTACTTTTTTAAATAAAGAAATTACAGAAGAAATGTCAAGTAATATTGAAGAAACAATAGTTTTTATTTATGTAGTTGTACATTTTTA AACTAAGGGCAATACACTGACATGGTTATGTGCATAAAAATTTTGACTTAAAGAACTGGAAGTTTATATACACCTGGACTATAAGAAACA GAAGAAAATCAGTCCACATTTTACAGTTAGCAGAGAATCCTAAATGGCACTGGCCTGGCCACCTTTTCATTTTACAAATGGGGGAAGTGA AGTGTGACCCCTTACTTGGCATAGGAAGTTAACTTACACCTAATAACTGACAGGTTTTTGTTTTGATGACCTATTAATTATGTAGCCTAG >In-frame_ENST00000291074_ENST00000520539_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(amino acids)=668AA_start in transcript=134_stop in transcript=2140 MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG QDGRQVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQT ELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYE EKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLQENRKRHGSSRSVVDMD LDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQ LILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLT AEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQH -------------------------------------------------------------- >In-frame_ENST00000291074_ENST00000220959_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(transcript)=2704nt_BP=1163nt GGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGGCCT GAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAGCCG TGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTGTTG AGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGACTGG ATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGTGAAAGAAATCACCCGTGATATTAAGCAAT TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGGAAAACC GAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAAC CTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGAC TATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATT TTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAA TGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTC CACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTC TACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGC AAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGC CTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATT CCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCT GTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTGGTA CCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTTTGC TAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGGGAA AAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCAAAA TAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATATGG AACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTTTGACTGCATT >In-frame_ENST00000291074_ENST00000220959_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(amino acids)=667AA_start in transcript=134_stop in transcript=2137 MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG QDGRQVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQT ELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYE EKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLENRKRHGSSRSVVDMDL DDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL ILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTA EDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHL -------------------------------------------------------------- >In-frame_ENST00000291074_ENST00000518205_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(transcript)=2242nt_BP=1163nt GGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGGCCT GAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAGCCG TGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTGTTG AGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGACTGG ATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGTGAAAGAAATCACCCGTGATATTAAGCAAT TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGGAAAACC GAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAAC CTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGAC TATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATT TTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAA TGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTC CACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTC TACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGC AAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGC CTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATT CCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCT >In-frame_ENST00000291074_ENST00000518205_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(amino acids)=667AA_start in transcript=134_stop in transcript=2137 MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG QDGRQVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQT ELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYE EKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLENRKRHGSSRSVVDMDL DDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL ILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTA EDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHL -------------------------------------------------------------- >In-frame_ENST00000291074_ENST00000521922_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(transcript)=2242nt_BP=1163nt GGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGGCCT GAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAGCCG TGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTGTTG AGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGACTGG ATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGTGAAAGAAATCACCCGTGATATTAAGCAAT TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGGAAAACC GAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAAC CTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGAC TATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATT TTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAA TGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTC CACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTC TACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGC AAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGC CTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATT CCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCT >In-frame_ENST00000291074_ENST00000521922_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(amino acids)=667AA_start in transcript=134_stop in transcript=2137 MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG QDGRQVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQT ELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWLDKIDRRYAWIKRQLVDYE EKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLENRKRHGSSRSVVDMDL DDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQL ILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTA EDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHL -------------------------------------------------------------- >In-frame_ENST00000571805_ENST00000520539_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(transcript)=3521nt_BP=1253nt AGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGG CCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAG CCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTG TTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGAC TGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAGAAAGCTATCC AACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGATATTAAGCAAT TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGCAGGAAA ACCGAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACC AACCTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTG GACTATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATG ATTTTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAG CAATGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCA CTCCACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAG GTCTACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATG TGCAAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAA TAGTAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCC AGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCT ATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATT GCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTG GTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTT TGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGG GAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCA AAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATA TGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTTTGACTGC ATTGAGCTCTAGGATATTAAATGATATCACTAATATTTTGCATGTAATTTGCTCATTTGAGTGAGGGCACTTTTTTTGTACATATGATGG GGCCAATGCACAATACTTTTATCACAATCAACTTTTTCTTTGTATCCCTATTTCAATGAGCAGTCAGTCTCAAGAGGTTACTGCACTTCA GTTCTAACTAGACATTTGTACTAAGGTATTTCAGTTATGTAAACTCAGCCTGGGCACTTTCTGATAACTGTAAAATGTTTTATAAGATCA TGATTATTGAAGATACATTTTGGAAAATTTTAAATGTTCGTGAGCAGCTTAACTACTTTTGTATCTAGCCTTTTTTAAGTATCTTGTTAC ATTTACTTTTTTAAATAAAGAAATTACAGAAGAAATGTCAAGTAATATTGAAGAAACAATAGTTTTTATTTATGTAGTTGTACATTTTTA AACTAAGGGCAATACACTGACATGGTTATGTGCATAAAAATTTTGACTTAAAGAACTGGAAGTTTATATACACCTGGACTATAAGAAACA GAAGAAAATCAGTCCACATTTTACAGTTAGCAGAGAATCCTAAATGGCACTGGCCTGGCCACCTTTTCATTTTACAAATGGGGGAAGTGA AGTGTGACCCCTTACTTGGCATAGGAAGTTAACTTACACCTAATAACTGACAGGTTTTTGTTTTGATGACCTATTAATTATGTAGCCTAG >In-frame_ENST00000571805_ENST00000520539_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(amino acids)=697AA_start in transcript=137_stop in transcript=2230 MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK RFSGCTLTDGTLQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNR HVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHR MLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYF -------------------------------------------------------------- >In-frame_ENST00000571805_ENST00000220959_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(transcript)=2794nt_BP=1253nt AGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGG CCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAG CCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTG TTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGAC TGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAGAAAGCTATCC AACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGATATTAAGCAAT TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGGAAAACC GAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAAC CTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGAC TATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATT TTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAA TGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTC CACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTC TACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGC AAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGC CTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATT CCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCT GTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTGGTA CCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTTTGC TAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGGGAA AAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCAAAA TAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATATGG AACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTTTGACTGCATT >In-frame_ENST00000571805_ENST00000220959_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(amino acids)=696AA_start in transcript=137_stop in transcript=2227 MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW -------------------------------------------------------------- >In-frame_ENST00000571805_ENST00000518205_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(transcript)=2332nt_BP=1253nt AGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGG CCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAG CCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTG TTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGAC TGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAGAAAGCTATCC AACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGATATTAAGCAAT TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGGAAAACC GAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAAC CTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGAC TATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATT TTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAA TGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTC CACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTC TACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGC AAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGC CTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATT CCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCT >In-frame_ENST00000571805_ENST00000518205_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(amino acids)=696AA_start in transcript=137_stop in transcript=2227 MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW -------------------------------------------------------------- >In-frame_ENST00000571805_ENST00000521922_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(transcript)=2332nt_BP=1253nt AGCGGCTGACAGAGCGGCTGACGGAGCCGGGCTCACCAGGTCGCTGCCGCGAGGGAGTTGCTGTGCTGGGGCCTGGGTGGCGGCTGGAGG CCTGAGTTGGGCTCGCGGCGGGGGTCGGCAGGGGGCCGGGTGGCGGAATGATGGAGGAGGAGGAACTGGAGTTCGTGGAGGAGCTGGAAG CCGTGCTGCAGCTCACGCCCGAGGTGCAGCTGGCCATCGAGCAGGTGTTTCCAAGCCAGGACCCTCTAGATCGAGCAGATTTCAATGCTG TTGAGTATATCAATACCCTGTTCCCAACCGAGCAATCTCTGGCGAACATAGACGAAGTCGTGAACAAAATTAGGCTGAAAATAAGGAGAC TGGATGACAATATTCGAACTGTTGTAAGAGGTCAGACGAACGTGGGGCAGGATGGACGGCAAGCGCTTGAAGAGGCTCAGAAAGCTATCC AACAACTCTTTGGCAAAATCAAAGATATCAAAGACAAAGCTGAAAAATCAGAGCAAATGGTGAAAGAAATCACCCGTGATATTAAGCAAT TAGATCACGCCAAACGCCACCTGACCACCTCAATCACCACACTGAACCACCTGCACATGCTGGCAGGAGGTGTCGACTCCCTCGAAGCCA TGACCAGGCGAAGACAATACGGAGAAGTTGCTAATCTCCTTCAGGGTGTGATGAATGTCCTGGAGCACTTCCACAAGTATATGGGGATTC CGCAGATCCGGCAGCTTTCCGAAAGAGTGAAGGCTGCACAGACTGAGTTAGGACAGCAAATCCTGGCAGATTTTGAAGAAGCGTTTCCTT CCCAGGGCACCAAGAGACCAGGAGGACCCAGCAATGTTCTACGAGATGCATGTCTGGTTGCTAATATTCTAGATCCCAGGATCAAACAGG AAATCATCAAAAAGTTTATTAAACAGCATCTGTCAGAGTATCTGGTACTTTTTCAAGAAAACCAAGATGTTGCCTGGCTGGACAAAATCG ACAGACGCTATGCCTGGATAAAACGCCAGCTTGTGGACTATGAGGAGAAATACGGCCGCATGTTTCCACGTGAGTGGTGCATGGCTGAGA GGATTGCGGTGGAATTTTGCCATGTGACAAGGGCAGAACTTGCCAAGATTATGCGTACCAGAGCGAAGGAAATTGAAGTGAAATTGCTTC TTTTTGCTATTCAAAGAACAACTAACTTTGAGGGGTTTCTTGCAAAACGCTTCTCCGGCTGCACCCTGACCGATGGGACCCTGGAAAACC GAAAGCGCCATGGCTCTAGTCGAAGTGTAGTAGATATGGATTTAGATGATACAGATGATGGTGATGACAATGCCCCTTTGTTTTACCAAC CTGGGAAAAGAGGATTTTATACTCCAAGGCCTGGCAAGAACACAGAAGCAAGGTTGAATTGTTTCAGAAACATTGGCAGGATTCTTGGAC TATGTCTGTTACAGAATGAACTATGTCCTATCACATTGAATAGACATGTAATTAAAGTATTGCTTGGTAGAAAAGTCAATTGGCATGATT TTGCTTTTTTTGATCCTGTAATGTATGAGAGTTTGCGGCAACTAATCCTCGCGTCTCAGAGTTCAGATGCTGATGCTGTTTTCTCAGCAA TGGATTTGGCATTTGCAATTGACCTGTGTAAAGAAGAAGGTGGAGGACAGGTTGAACTCATTCCTAATGGTGTAAATATACCAGTCACTC CACAGAATGTATATGAGTATGTGCGGAAATACGCAGAACACAGAATGTTGGTAGTTGCAGAACAGCCCTTACATGCAATGAGGAAAGGTC TACTAGATGTGCTTCCAAAAAATTCATTAGAAGATTTAACGGCAGAAGATTTTAGGCTTTTGGTAAATGGCTGCGGTGAAGTCAATGTGC AAATGCTGATCAGTTTTACCTCTTTCAATGATGAATCAGGAGAAAATGCTGAGAAGCTTCTGCAGTTCAAGCGTTGGTTCTGGTCAATAG TAGAGAAGATGAGCATGACAGAACGACAAGATCTTGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGC CTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATT CCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCT >In-frame_ENST00000571805_ENST00000521922_TCGA-IN-8462-11A_VPS53_chr17_526773_-_UBR5_chr8_103277506_length(amino acids)=696AA_start in transcript=137_stop in transcript=2227 MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVG QDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQG VMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLV LFQENQDVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAK RFSGCTLTDGTLENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRH VIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRM LVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for VPS53-UBR5 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for VPS53-UBR5 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for VPS53-UBR5 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | VPS53 | C4014488 | PONTOCEREBELLAR HYPOPLASIA, TYPE 2E | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | VPS53 | C0266468 | Congenital pontocerebellar hypoplasia | 1 | GENOMICS_ENGLAND |
Hgene | VPS53 | C0424605 | Developmental delay (disorder) | 1 | GENOMICS_ENGLAND |
Hgene | VPS53 | C0557874 | Global developmental delay | 1 | GENOMICS_ENGLAND |
Hgene | VPS53 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |