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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:VRK2-FANCL (FusionGDB2 ID:97869)

Fusion Gene Summary for VRK2-FANCL

check button Fusion gene summary
Fusion gene informationFusion gene name: VRK2-FANCL
Fusion gene ID: 97869
HgeneTgene
Gene symbol

VRK2

FANCL

Gene ID

7444

55120

Gene nameVRK serine/threonine kinase 2FA complementation group L
Synonyms-FAAP43|PHF9|POG
Cytomap

2p16.1

2p16.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase VRK2vaccinia related kinase 2vaccinia virus B1R-related kinase 2E3 ubiquitin-protein ligase FANCLFanconi anemia complementation group LPHD finger protein 9RING-type E3 ubiquitin transferase FANCLfanconi anemia group L proteinfanconi anemia-associated polypeptide of 43 kDa
Modification date2020031320200313
UniProtAcc.

Q9NW38

Ensembl transtripts involved in fusion geneENST00000435505, ENST00000417641, 
ENST00000478687, ENST00000412104, 
ENST00000340157, ENST00000440705, 
ENST00000403295, ENST00000402135, 
ENST00000233741, ENST00000403676, 
ENST00000540646, ENST00000481670, 
Fusion gene scores* DoF score5 X 6 X 3=902 X 5 X 2=20
# samples 54
** MAII scorelog2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/20*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: VRK2 [Title/Abstract] AND FANCL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointVRK2(58316858)-FANCL(58393009), # samples:2
FANCL(58425729)-VRK2(58350236), # samples:1
Anticipated loss of major functional domain due to fusion event.VRK2-FANCL seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
VRK2-FANCL seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVRK2

GO:0046777

protein autophosphorylation

14645249|16704422

TgeneFANCL

GO:0006513

protein monoubiquitination

16916645|24389026


check buttonFusion gene breakpoints across VRK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FANCL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1NF-01AVRK2chr2

58316858

+FANCLchr2

58393009

-
ChimerDB4CESCTCGA-C5-A7UH-01AVRK2chr2

58316858

+FANCLchr2

58393009

-
ChimerDB4BRCATCGA-E9-A1NF-01AVRK2chr2

58316857

+FANCLchr2

58393008

-
ChiTaRS5.0N/ACN421381VRK2chr2

58386502

+FANCLchr2

58392925

-


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Fusion Gene ORF analysis for VRK2-FANCL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000435505ENST00000403295VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000435505ENST00000402135VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000435505ENST00000233741VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000435505ENST00000403676VRK2chr2

58316858

+FANCLchr2

58393009

-
Frame-shiftENST00000435505ENST00000540646VRK2chr2

58316858

+FANCLchr2

58393009

-
5CDS-intronENST00000435505ENST00000481670VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000417641ENST00000403295VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000417641ENST00000402135VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000417641ENST00000233741VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000417641ENST00000403676VRK2chr2

58316858

+FANCLchr2

58393009

-
Frame-shiftENST00000417641ENST00000540646VRK2chr2

58316858

+FANCLchr2

58393009

-
5CDS-intronENST00000417641ENST00000481670VRK2chr2

58316858

+FANCLchr2

58393009

-
intron-3CDSENST00000478687ENST00000403295VRK2chr2

58316858

+FANCLchr2

58393009

-
intron-3CDSENST00000478687ENST00000402135VRK2chr2

58316858

+FANCLchr2

58393009

-
intron-3CDSENST00000478687ENST00000233741VRK2chr2

58316858

+FANCLchr2

58393009

-
intron-3CDSENST00000478687ENST00000403676VRK2chr2

58316858

+FANCLchr2

58393009

-
intron-3CDSENST00000478687ENST00000540646VRK2chr2

58316858

+FANCLchr2

58393009

-
intron-intronENST00000478687ENST00000481670VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000412104ENST00000403295VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000412104ENST00000402135VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000412104ENST00000233741VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000412104ENST00000403676VRK2chr2

58316858

+FANCLchr2

58393009

-
Frame-shiftENST00000412104ENST00000540646VRK2chr2

58316858

+FANCLchr2

58393009

-
5CDS-intronENST00000412104ENST00000481670VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000340157ENST00000403295VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000340157ENST00000402135VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000340157ENST00000233741VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000340157ENST00000403676VRK2chr2

58316858

+FANCLchr2

58393009

-
Frame-shiftENST00000340157ENST00000540646VRK2chr2

58316858

+FANCLchr2

58393009

-
5CDS-intronENST00000340157ENST00000481670VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000440705ENST00000403295VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000440705ENST00000402135VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000440705ENST00000233741VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000440705ENST00000403676VRK2chr2

58316858

+FANCLchr2

58393009

-
Frame-shiftENST00000440705ENST00000540646VRK2chr2

58316858

+FANCLchr2

58393009

-
5CDS-intronENST00000440705ENST00000481670VRK2chr2

58316858

+FANCLchr2

58393009

-
In-frameENST00000435505ENST00000403295VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000435505ENST00000402135VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000435505ENST00000233741VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000435505ENST00000403676VRK2chr2

58316857

+FANCLchr2

58393008

-
Frame-shiftENST00000435505ENST00000540646VRK2chr2

58316857

+FANCLchr2

58393008

-
5CDS-intronENST00000435505ENST00000481670VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000417641ENST00000403295VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000417641ENST00000402135VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000417641ENST00000233741VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000417641ENST00000403676VRK2chr2

58316857

+FANCLchr2

58393008

-
Frame-shiftENST00000417641ENST00000540646VRK2chr2

58316857

+FANCLchr2

58393008

-
5CDS-intronENST00000417641ENST00000481670VRK2chr2

58316857

+FANCLchr2

58393008

-
intron-3CDSENST00000478687ENST00000403295VRK2chr2

58316857

+FANCLchr2

58393008

-
intron-3CDSENST00000478687ENST00000402135VRK2chr2

58316857

+FANCLchr2

58393008

-
intron-3CDSENST00000478687ENST00000233741VRK2chr2

58316857

+FANCLchr2

58393008

-
intron-3CDSENST00000478687ENST00000403676VRK2chr2

58316857

+FANCLchr2

58393008

-
intron-3CDSENST00000478687ENST00000540646VRK2chr2

58316857

+FANCLchr2

58393008

-
intron-intronENST00000478687ENST00000481670VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000412104ENST00000403295VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000412104ENST00000402135VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000412104ENST00000233741VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000412104ENST00000403676VRK2chr2

58316857

+FANCLchr2

58393008

-
Frame-shiftENST00000412104ENST00000540646VRK2chr2

58316857

+FANCLchr2

58393008

-
5CDS-intronENST00000412104ENST00000481670VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000340157ENST00000403295VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000340157ENST00000402135VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000340157ENST00000233741VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000340157ENST00000403676VRK2chr2

58316857

+FANCLchr2

58393008

-
Frame-shiftENST00000340157ENST00000540646VRK2chr2

58316857

+FANCLchr2

58393008

-
5CDS-intronENST00000340157ENST00000481670VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000440705ENST00000403295VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000440705ENST00000402135VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000440705ENST00000233741VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000440705ENST00000403676VRK2chr2

58316857

+FANCLchr2

58393008

-
Frame-shiftENST00000440705ENST00000540646VRK2chr2

58316857

+FANCLchr2

58393008

-
5CDS-intronENST00000440705ENST00000481670VRK2chr2

58316857

+FANCLchr2

58393008

-
In-frameENST00000435505ENST00000403295VRK2chr2

58386502

+FANCLchr2

58392925

-
In-frameENST00000435505ENST00000402135VRK2chr2

58386502

+FANCLchr2

58392925

-
In-frameENST00000435505ENST00000233741VRK2chr2

58386502

+FANCLchr2

58392925

-
In-frameENST00000435505ENST00000403676VRK2chr2

58386502

+FANCLchr2

58392925

-
5CDS-3UTRENST00000435505ENST00000540646VRK2chr2

58386502

+FANCLchr2

58392925

-
5CDS-intronENST00000435505ENST00000481670VRK2chr2

58386502

+FANCLchr2

58392925

-
3UTR-3CDSENST00000417641ENST00000403295VRK2chr2

58386502

+FANCLchr2

58392925

-
3UTR-3CDSENST00000417641ENST00000402135VRK2chr2

58386502

+FANCLchr2

58392925

-
3UTR-3CDSENST00000417641ENST00000233741VRK2chr2

58386502

+FANCLchr2

58392925

-
3UTR-3CDSENST00000417641ENST00000403676VRK2chr2

58386502

+FANCLchr2

58392925

-
3UTR-3UTRENST00000417641ENST00000540646VRK2chr2

58386502

+FANCLchr2

58392925

-
3UTR-intronENST00000417641ENST00000481670VRK2chr2

58386502

+FANCLchr2

58392925

-
intron-3CDSENST00000478687ENST00000403295VRK2chr2

58386502

+FANCLchr2

58392925

-
intron-3CDSENST00000478687ENST00000402135VRK2chr2

58386502

+FANCLchr2

58392925

-
intron-3CDSENST00000478687ENST00000233741VRK2chr2

58386502

+FANCLchr2

58392925

-
intron-3CDSENST00000478687ENST00000403676VRK2chr2

58386502

+FANCLchr2

58392925

-
intron-3UTRENST00000478687ENST00000540646VRK2chr2

58386502

+FANCLchr2

58392925

-
intron-intronENST00000478687ENST00000481670VRK2chr2

58386502

+FANCLchr2

58392925

-
3UTR-3CDSENST00000412104ENST00000403295VRK2chr2

58386502

+FANCLchr2

58392925

-
3UTR-3CDSENST00000412104ENST00000402135VRK2chr2

58386502

+FANCLchr2

58392925

-
3UTR-3CDSENST00000412104ENST00000233741VRK2chr2

58386502

+FANCLchr2

58392925

-
3UTR-3CDSENST00000412104ENST00000403676VRK2chr2

58386502

+FANCLchr2

58392925

-
3UTR-3UTRENST00000412104ENST00000540646VRK2chr2

58386502

+FANCLchr2

58392925

-
3UTR-intronENST00000412104ENST00000481670VRK2chr2

58386502

+FANCLchr2

58392925

-
Frame-shiftENST00000340157ENST00000403295VRK2chr2

58386502

+FANCLchr2

58392925

-
Frame-shiftENST00000340157ENST00000402135VRK2chr2

58386502

+FANCLchr2

58392925

-
Frame-shiftENST00000340157ENST00000233741VRK2chr2

58386502

+FANCLchr2

58392925

-
Frame-shiftENST00000340157ENST00000403676VRK2chr2

58386502

+FANCLchr2

58392925

-
5CDS-3UTRENST00000340157ENST00000540646VRK2chr2

58386502

+FANCLchr2

58392925

-
5CDS-intronENST00000340157ENST00000481670VRK2chr2

58386502

+FANCLchr2

58392925

-
Frame-shiftENST00000440705ENST00000403295VRK2chr2

58386502

+FANCLchr2

58392925

-
Frame-shiftENST00000440705ENST00000402135VRK2chr2

58386502

+FANCLchr2

58392925

-
Frame-shiftENST00000440705ENST00000233741VRK2chr2

58386502

+FANCLchr2

58392925

-
Frame-shiftENST00000440705ENST00000403676VRK2chr2

58386502

+FANCLchr2

58392925

-
5CDS-3UTRENST00000440705ENST00000540646VRK2chr2

58386502

+FANCLchr2

58392925

-
5CDS-intronENST00000440705ENST00000481670VRK2chr2

58386502

+FANCLchr2

58392925

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for VRK2-FANCL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for VRK2-FANCL


check button Go to

FGviewer for the breakpoints of chr2:58316858-chr2:58393009

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FANCL

Q9NW38

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026). Also mediates monoubiquitination of FANCI (PubMed:19589784). May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. {ECO:0000269|PubMed:12973351, ECO:0000269|PubMed:16916645, ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:24389026}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVRK2chr2:58316857chr2:58393008ENST00000340157+71335_43181.0509.0Nucleotide bindingATP
HgeneVRK2chr2:58316857chr2:58393008ENST00000412104+71435_43181.0511.6666666666667Nucleotide bindingATP
HgeneVRK2chr2:58316857chr2:58393008ENST00000417641+91635_43181.0508.3333333333333Nucleotide bindingATP
HgeneVRK2chr2:58316857chr2:58393008ENST00000435505+101635_43181.0509.0Nucleotide bindingATP
HgeneVRK2chr2:58316857chr2:58393008ENST00000440705+71335_43158.0486.0Nucleotide bindingATP
HgeneVRK2chr2:58316858chr2:58393009ENST00000340157+71335_43181.0509.0Nucleotide bindingATP
HgeneVRK2chr2:58316858chr2:58393009ENST00000412104+71435_43181.0511.6666666666667Nucleotide bindingATP
HgeneVRK2chr2:58316858chr2:58393009ENST00000417641+91635_43181.0508.3333333333333Nucleotide bindingATP
HgeneVRK2chr2:58316858chr2:58393009ENST00000435505+101635_43181.0509.0Nucleotide bindingATP
HgeneVRK2chr2:58316858chr2:58393009ENST00000440705+71335_43158.0486.0Nucleotide bindingATP
TgeneFANCLchr2:58386502chr2:58392925ENST00000233741014104_2940376.0RegionNote=UBC-RWD region (URD)
TgeneFANCLchr2:58386502chr2:58392925ENST00000402135014104_2940381.0RegionNote=UBC-RWD region (URD)
TgeneFANCLchr2:58316857chr2:58393008ENST00000233741614307_365180.0376.0Zinc fingerNote=RING-type
TgeneFANCLchr2:58316857chr2:58393008ENST00000402135614307_365185.0381.0Zinc fingerNote=RING-type
TgeneFANCLchr2:58316858chr2:58393009ENST00000233741614307_365180.0376.0Zinc fingerNote=RING-type
TgeneFANCLchr2:58316858chr2:58393009ENST00000402135614307_365185.0381.0Zinc fingerNote=RING-type
TgeneFANCLchr2:58386502chr2:58392925ENST00000233741014307_3650376.0Zinc fingerNote=RING-type
TgeneFANCLchr2:58386502chr2:58392925ENST00000402135014307_3650381.0Zinc fingerNote=RING-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVRK2chr2:58316857chr2:58393008ENST00000340157+71329_319181.0509.0DomainProtein kinase
HgeneVRK2chr2:58316857chr2:58393008ENST00000412104+71429_319181.0511.6666666666667DomainProtein kinase
HgeneVRK2chr2:58316857chr2:58393008ENST00000417641+91629_319181.0508.3333333333333DomainProtein kinase
HgeneVRK2chr2:58316857chr2:58393008ENST00000435505+101629_319181.0509.0DomainProtein kinase
HgeneVRK2chr2:58316857chr2:58393008ENST00000440705+71329_319158.0486.0DomainProtein kinase
HgeneVRK2chr2:58316858chr2:58393009ENST00000340157+71329_319181.0509.0DomainProtein kinase
HgeneVRK2chr2:58316858chr2:58393009ENST00000412104+71429_319181.0511.6666666666667DomainProtein kinase
HgeneVRK2chr2:58316858chr2:58393009ENST00000417641+91629_319181.0508.3333333333333DomainProtein kinase
HgeneVRK2chr2:58316858chr2:58393009ENST00000435505+101629_319181.0509.0DomainProtein kinase
HgeneVRK2chr2:58316858chr2:58393009ENST00000440705+71329_319158.0486.0DomainProtein kinase
HgeneVRK2chr2:58386502chr2:58392925ENST00000340157+11329_3190509.0DomainProtein kinase
HgeneVRK2chr2:58386502chr2:58392925ENST00000412104+11429_3190511.6666666666667DomainProtein kinase
HgeneVRK2chr2:58386502chr2:58392925ENST00000417641+11629_3190508.3333333333333DomainProtein kinase
HgeneVRK2chr2:58386502chr2:58392925ENST00000435505+11629_3190509.0DomainProtein kinase
HgeneVRK2chr2:58386502chr2:58392925ENST00000440705+11329_3190486.0DomainProtein kinase
HgeneVRK2chr2:58386502chr2:58392925ENST00000340157+11335_430509.0Nucleotide bindingATP
HgeneVRK2chr2:58386502chr2:58392925ENST00000412104+11435_430511.6666666666667Nucleotide bindingATP
HgeneVRK2chr2:58386502chr2:58392925ENST00000417641+11635_430508.3333333333333Nucleotide bindingATP
HgeneVRK2chr2:58386502chr2:58392925ENST00000435505+11635_430509.0Nucleotide bindingATP
HgeneVRK2chr2:58386502chr2:58392925ENST00000440705+11335_430486.0Nucleotide bindingATP
HgeneVRK2chr2:58316857chr2:58393008ENST00000340157+713487_507181.0509.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58316857chr2:58393008ENST00000412104+714487_507181.0511.6666666666667TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58316857chr2:58393008ENST00000417641+916487_507181.0508.3333333333333TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58316857chr2:58393008ENST00000435505+1016487_507181.0509.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58316857chr2:58393008ENST00000440705+713487_507158.0486.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58316858chr2:58393009ENST00000340157+713487_507181.0509.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58316858chr2:58393009ENST00000412104+714487_507181.0511.6666666666667TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58316858chr2:58393009ENST00000417641+916487_507181.0508.3333333333333TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58316858chr2:58393009ENST00000435505+1016487_507181.0509.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58316858chr2:58393009ENST00000440705+713487_507158.0486.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58386502chr2:58392925ENST00000340157+113487_5070509.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58386502chr2:58392925ENST00000412104+114487_5070511.6666666666667TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58386502chr2:58392925ENST00000417641+116487_5070508.3333333333333TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58386502chr2:58392925ENST00000435505+116487_5070509.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneVRK2chr2:58386502chr2:58392925ENST00000440705+113487_5070486.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneFANCLchr2:58316857chr2:58393008ENST00000233741614104_294180.0376.0RegionNote=UBC-RWD region (URD)
TgeneFANCLchr2:58316857chr2:58393008ENST00000402135614104_294185.0381.0RegionNote=UBC-RWD region (URD)
TgeneFANCLchr2:58316858chr2:58393009ENST00000233741614104_294180.0376.0RegionNote=UBC-RWD region (URD)
TgeneFANCLchr2:58316858chr2:58393009ENST00000402135614104_294185.0381.0RegionNote=UBC-RWD region (URD)


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Fusion Gene Sequence for VRK2-FANCL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for VRK2-FANCL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for VRK2-FANCL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for VRK2-FANCL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneVRK2C0036341Schizophrenia2PSYGENET
TgeneFANCLC0015625Fanconi Anemia6CTD_human;GENOMICS_ENGLAND
TgeneFANCLC3469528FANCONI ANEMIA, COMPLEMENTATION GROUP L5CTD_human;GENOMICS_ENGLAND
TgeneFANCLC0023465Acute monocytic leukemia1GENOMICS_ENGLAND
TgeneFANCLC0023467Leukemia, Myelocytic, Acute1GENOMICS_ENGLAND
TgeneFANCLC0030312Pancytopenia1GENOMICS_ENGLAND
TgeneFANCLC0265219Miller Dieker syndrome1GENOMICS_ENGLAND
TgeneFANCLC1855710Bone marrow hypocellularity1GENOMICS_ENGLAND
TgeneFANCLC3463824MYELODYSPLASTIC SYNDROME1GENOMICS_ENGLAND
TgeneFANCLC4228778Abnormality of radial ray1GENOMICS_ENGLAND